|
Name |
Accession |
Description |
Interval |
E-value |
| Na_symport_lg |
TIGR03648 |
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of ... |
7-558 |
0e+00 |
|
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of transporters of the sodium:solute symporter superfamily, TC 2.A.21. Members of this strictly bacterial protein subfamily are found almost invariably immediately downstream from a member of family TIGR03647. Occasionally, the two genes are fused.
Pssm-ID: 274698 Cd Length: 552 Bit Score: 886.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 7 TFILVGITFAVYIGIAIWARAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYLMGWTGGYVL 86
Cdd:TIGR03648 1 TYLFVGATFALYIGIGIWSRAGSTSEFYVAGRGVPPVANGMATAADWMSAASFISMAGLIAFLGYDGLAYLMGWTGGYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 87 LALCLAPYLRKFGQFTVPDFIGERYYSKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMGIVFFYA 166
Cdd:TIGR03648 81 LALLLAPYLRKFGKYTVPDFIGDRYYSNTARLVAVICAIFISFTYVAGQMRGVGVVFSRFLEVDFETGVFIGMAIVFFYA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 167 VLGGMKGITYTQVAQFCVLIFAFLVPAIFTSIMMTGNPLPQVGMGSTLSGtdVYLLDKLDGLTEELGFTAYTE--GNKSM 244
Cdd:TIGR03648 161 VLGGMKGVTWTQVAQYIVLIVAYLVPAIFISLKLTGNPVPQLGYGSALSG--VYLLDKLDELEVDLGFAEYTEpfGSKSR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 245 VDVFFICAALMVGTAGLPHVIIRFFTVPKVRDARISAGWALLFISLLYTTAPGVAAFARVNMIETINgpdmqGVAAADAP 324
Cdd:TIGR03648 239 INVFALTLALMVGTAGLPHVIVRFYTVPKVRDARWSAGWALFFIALLYTTAPAVAAFARYNLITTVN-----GTPYAELP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 325 SWYKNWESTGLVGWEDKNGDGKMFYSGDERNEMKINRDIIVLASPELAKLPNWVVALLAAGGLAAALSTAAGLLLVISTS 404
Cdd:TIGR03648 314 GWVANWEKTGLLKFEDKNGDGILQYSGDAGNELTIDRDIIVLATPEIAGLPYWVIGLVAAGGLAAALSTAAGLLLVISSA 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 405 ISHDLLKKGFRPNMTDKQELLAARLAAMVAIVGAGYLGINPPGFVAQVVAFAFGLAAASFFPAIILGIFYKKMNKEGAIA 484
Cdd:TIGR03648 394 ISHDLYYRIINPNASEKQRLLVARIALVVAAVIAGYFGLNPPGFIAQVVAFAFGLAAASFFPALVLGIFWKRMNREGAIA 473
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1715703716 485 GMLSGIAFTASYIIYFK-----FINPAASTPENWWFGISPEGIGTLGMCLNFVVSIAVNKVTAEVPQDVQDMVENIRYP 558
Cdd:TIGR03648 474 GMLTGLGFTFSYIVYFKpwgfiGTNPGANVPENWWFGISPEGIGLIGMPVNFAVAIVVSLVTPPPPQEIQDLVEDIRYP 552
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
1-564 |
0e+00 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 610.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 1 MDIQTWTFILVGITFAVYIGIAIWARAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYLMGW 80
Cdd:COG4147 10 MNLLAIGIFLVFVTFTLYITIWAARRTKSTSDFYVAGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLIYSIGW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 81 TGGYVLLALCLAPYLRKFGQFTVPDFIGERYYSKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMG 160
Cdd:COG4147 90 LVGYVLLLLLLAEYLRNFGKFTVPDFLGDRFYSRPARLVAAISTLVVSFFYLIAQMVGAGVLISLLLGVDYEVAVVIVGV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 161 IVFFYAVLGGMKGITYTQVAQFCVLIFAFLVPAIFTSIMMTGNPLPqvgmgstlsgtdvyLLDKLDGLtEELGfTAYTE- 239
Cdd:COG4147 170 LMIVYVVLGGMKGTTWVQIIKAVLLIFAYTVPAVLVLAQFGFNPLP--------------LLAKAAEV-HDLG-AAYLEp 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 240 --GNKSMVDVFFICAALMVGTAGLPHVIIRFFTVPKVRDARISAGWALLFISLLYTTAPGVAAFARVNMietingpdmqg 317
Cdd:COG4147 234 ggLVKSPLDFISLGLALMLGTAGLPHILMRFFTVPDAKEARKSVGWALGFIGLFYLTAPALGFGARALV----------- 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 318 vaaADAPSWYKnwesTGLVGWEDKNGdgkmfysgdernemkinrDIIVLASPELAKLPNWVVALLAAGGLAAALSTAAGL 397
Cdd:COG4147 303 ---GPLPEWFD----TGLIGAADGGG------------------NMAVLALAEIAGGGNWLLGLVAAGAFATILAVVAGL 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 398 LLVISTSISHDLLKKGFRPNMTDKQELLAARLAAMVAIVGAGYLGIN-PPGFVAQVVAFAFGLAAASFFPAIILGIFYKK 476
Cdd:COG4147 358 LLAIASAISHDLYANVIKGKATEKEELRVARIAAVVIGVVAILLGINaPPQNVAFLVALAFALAASANFPVLLLSIFWKR 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 477 MNKEGAIAGMLSGIAFTASYIIYFKFINPAAStpENWWFGIspEGIGTLGMCLNFVVSIAVNKVTAEVPQDVQDMVEN-- 554
Cdd:COG4147 438 FNTRGAVAGMLVGLISALVLIVLSPFVWVLGV--DAALFPL--ENPGLVSMPLGFLVAIVVSLLTPEPPAEDQELVEEqe 513
|
570
....*....|
gi 1715703716 555 IRYPKGAGEA 564
Cdd:COG4147 514 VRSPTGIGAA 523
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
6-540 |
0e+00 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 537.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 6 WTFILVGITFAVYIGIAIWARAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYLMGWTGGYV 85
Cdd:cd11480 1 IGLFFVFVTITLYITIWAARRTRSTSDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLAYAIGWTGGYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 86 LLALCLAPYLRKFGQFTVPDFIGERYYSKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMGIVFFY 165
Cdd:cd11480 81 LLLLLVAEPLRNFGKYTVPDFLGARLGSRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGIPYEVGVVVVGALMIVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 166 AVLGGMKGITYTQVAQFCVLIFAFLVPAIFTSIMMTGNPLPQvgmgstlsgtDVYLLDKLDGLTEELGFTAYTEGN--KS 243
Cdd:cd11480 161 VVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARFGGNPLGA----------GPGLLGLAAAAASGAGEAYLAPGLllTD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 244 MVDVFFICAALMVGTAGLPHVIIRFFTVPKVRDARISAGWALLFISLLYTTAPGVAAFARVNMIETINGpdmqgvaaada 323
Cdd:cd11480 231 PLDVISLTLALMLGTAGLPHVLMRFYTVPDARAARKSVVWALGFIGLFYLLAPALGFGARALVGPDVIG----------- 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 324 pswyknwestglvgwedkngdgkmfysGDERNEMKINRDIIVLASPELAKLPNWVVALLAAGGLAAALSTAAGLLLVIST 403
Cdd:cd11480 300 ---------------------------APIAGELDGGGDMAVLLLPEIAGLGDLLLALVAAGAFAAILATVAGLLLAAAS 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 404 SISHDLLKKGFRPNMTDKQELLAARLAAMVAIVGAGYLGIN-PPGFVAQVVAFAFGLAAASFFPAIILGIFYKKMNKEGA 482
Cdd:cd11480 353 ALAHDLYAGVIRPGASERREVRVARIAAVVVGVIAILLALLfPPQNVAFLVALAFAIAASAFFPVLVLGIFWRRFTTRGA 432
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1715703716 483 IAGMLSGIAFTASYIIYFKFINPAasTPENWWFGISPEGIGTLGMCLNFVVSIAVNKV 540
Cdd:cd11480 433 IAGMLVGLLVSLVLIVLSPAVSGA--PPGHDFAGFPLTNPGLVSVPLGFLVAIVVSLL 488
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
1-550 |
5.54e-66 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 222.39 E-value: 5.54e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 1 MDIQTWTFILVGITFAVYIGIAIWARAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYLMGW 80
Cdd:COG0591 1 MSTLDLIIIILYLLLLLGIGLYASRRTKSLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 81 TGGYVLLALCLAPYLRKFGQFTVPDFIGERyYSKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMG 160
Cdd:COG0591 81 ALGALLLALFFAPRLRRLGALTIPEFLEKR-FGRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILIGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 161 IVFFYAVLGGMKGITYTQVAQFCVLIFAFLVPAIFTSIMMTGnplpqvgmgstlsgtdvylldkLDGLTEEL---GFTAY 237
Cdd:COG0591 160 IVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALGG----------------------FGELFAALpapGLLSL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 238 TEGNKSMVDVFFICAAL--MVGTAGLPHVIIRFFTVPKVRDARISAGWALLFISLLYTTAPGVAAFARVNMietingPDM 315
Cdd:COG0591 218 FPGLGFTGWLAFLGLFLaiGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALF------PDL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 316 QGVAAADApswyknwestglvgwedkngdgkmfysgdernemkinrdIIVLAspeLAKLPNWVVALLAAGGLAAALSTAA 395
Cdd:COG0591 292 PLADPDLA---------------------------------------LPLLI---LELLPPGLAGLLLAAILAAAMSTAD 329
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 396 GLLLVISTSISHDLLKKGFRPNMTDKQELLAARLAAMVAIVGAGYLGINPPGFVAQVVAFAFGLAAASFFPAIILGIFYK 475
Cdd:COG0591 330 SQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLFPSSILDLVLLAWGGLGAALLPPLLLGLFWK 409
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1715703716 476 KMNKEGAIAGMLSGIAFTasyiIYFKFINPAASTPENWWFGIspegigtLGMCLNFVVSIAVNKVTAEVPQDVQD 550
Cdd:COG0591 410 RATKAGALAGMIAGLVVV----LLWKLLGGPLGPFGWLYPIL-------PGLLVSLLVFVVVSLLTKPPSEEVLE 473
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
6-538 |
1.34e-60 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 207.41 E-value: 1.34e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 6 WTFILVGITFAVYIGIAIWARAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYLMGWTGGYV 85
Cdd:cd10322 3 LIIVVVYLALLLGIGLYASKKVKSSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAALGAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 86 LLALCLAPYLRKFGQFTVPDFIGERYYSKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMGIVFFY 165
Cdd:cd10322 83 LLALFLAPRLRRLGKTTIPETILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVIVILY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 166 AVLGGMKGITYTQVAQFCVLIFAFLVPAIFTSIMMTGNPlpqvgmgstlsgtdvylLDKLDGLTEELGFTAYTEGNKSMV 245
Cdd:cd10322 163 TVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGGG-----------------FSALAAALPALLLALGPGGGLGWS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 246 DVFFICAALMVGTAGLPHVIIRFFTVPKVRDARISAGWALLFISLLYTTAPGVAAFARVnMIETINGPDMqgvaaadaps 325
Cdd:cd10322 226 TILSLILLTGLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARA-LFPDLENPDL---------- 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 326 wyknwestglvgwedkngdgkmfysgdernemkinrdiivlASPELAK--LPNWVVALLAAGGLAAALSTAAGLLLVIST 403
Cdd:cd10322 295 -----------------------------------------ALPTLINslLPPGLAGLVLAGLLAAAMSTADSLLLAAST 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 404 SISHDLLKKGFRPNMTDKQELLAARLAAMVAIVGAGYLGINPPGfVAQVVAFAFGLAAASFFPAIILGIFYKKMNKEGAI 483
Cdd:cd10322 334 LFTRDIYKPLINPKASDKKLLRVSRIAVVVVGVLALLLALLPPS-ILLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAI 412
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 1715703716 484 AGMLSGIAFTASYIIYfkfinpaastPENWWFGISPegiGTLGMCLNFVVSIAVN 538
Cdd:cd10322 413 AGIIVGLIVTLVWLLL----------PLASPLGIDP---IIPALLVSLIVFVVVS 454
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
13-504 |
1.96e-50 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 180.40 E-value: 1.96e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 13 ITFAVY----IGIAIWA--RAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYLMGWTGGYVL 86
Cdd:cd11475 2 ITFIVYlllmLGIGIYSyrKTKTLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAIWIAIGLILGAYL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 87 LALCLAPYLRKFGQF----TVPDFIGERY--YSKTARMV-AVFCAIFVSFtYVAGQMRGVGVVFSRFLEVDINLGIIIGM 159
Cdd:cd11475 82 NWLFVAKRLRRYTEKndsiTLPDYLENRFrdKSKLLRILsALIILIFFTI-YAAAQLVAGGKLFESLFGIDYSTGLLIGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 160 GIVFFYAVLGGMKGITYTQVAQFCVLIFAFLVpAIFTSIMMTGNPLpqvGMGSTLSGTDVYLLDkldglteelgftaYTE 239
Cdd:cd11475 161 VVVVAYTFLGGFLAVSWTDFFQGLLMLLALVL-VPIVALAALGGLS---GLVAALAAIDPGLLS-------------PFG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 240 GNKSMVDVFFICAALM--VGTAGLPHVIIRFFTVPKVRDARISAGWALLFISLLYTTAPGVAAFARVnMIETINGPDMQG 317
Cdd:cd11475 224 GDLGAGGLLAIISLLAwgLGYFGQPHILVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRA-LFPDGLLGDPET 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 318 VaaadapswyknwestglvgwedkngdgkmfysgdernemkinrdIIVLAspeLAKLPNWVVALLAAGGLAAALSTAAGL 397
Cdd:cd11475 303 V--------------------------------------------FPVLA---QELFPPWLAGILLAAILAAIMSTADSQ 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 398 LLVISTSISHDLLKKGFRPNMTDKQELLAARLAAMVAIVGAGYLGINPPGFVAQVVAFAFGLAAASFFPAIILGIFYKKM 477
Cdd:cd11475 336 LLVCSSALTEDLYKAFLRKEASDKELVWVSRLAVLVIALIALLIALNPPSSVFSLVSFAWAGLGAAFGPLLLLSLYWKRT 415
|
490 500
....*....|....*....|....*..
gi 1715703716 478 NKEGAIAGMLSGIAFTASYIIYFKFIN 504
Cdd:cd11475 416 TRQGALAGMIAGAVTVVVWKLLGLGIF 442
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
36-489 |
2.67e-42 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 156.69 E-value: 2.67e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 36 AGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYLMGWTGGYVLLALCLAPYLRKFGQFTVPDFIGERYYSKT 115
Cdd:TIGR00813 1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGKRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 116 ARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMGIVFFYAVLGGMKGITYTQVAQFCVLIFAFLVPAIF 195
Cdd:TIGR00813 81 LRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPVF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 196 TSIMMTGnplpqvgmgstlsgtdvylldkldglteelgftaytegnksmVDVFFICAALMVGTAGLPHVIIRFFTVPKVR 275
Cdd:TIGR00813 161 AFSEVGG------------------------------------------LGTFVEKASQAAPTNPSPDDLYDFFRDPSTS 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 276 DARISAGWALLFI----------SLLYTTAPGVAAFARVNMIEtingpDMQGVAAADAPSWYKNWESTGLVGWEDKNGDG 345
Cdd:TIGR00813 199 DLPWGAGVFGLPHvalwywtnqvIVQRCLAAKSAKHAKKGCLI-----SGVLKLLPMFGAVLPGLIARALYTDIDPALAG 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 346 KMFYSGDernemkinrDIIVLASPELakLPNWVVALLAAGGLAAALSTAAGLLLVISTSISHDLLKKGFRPNMTDKQELL 425
Cdd:TIGR00813 274 AVNQNSD---------QAYPLLVQEL--MPPGLAGLFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASGEKKIV 342
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1715703716 426 -AARLAAMVAIVGAGYLGINPPGFVAQVVAFAFGLAAASFFPAIILGIFYKKMNKEGAIAGMLSG 489
Cdd:TIGR00813 343 mRGRIAVLVAAVIAGFVAAAQGGQVLQYVQEAFGGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
33-489 |
7.54e-42 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 155.19 E-value: 7.54e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 33 FYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYLMGWTGGYVLLALCLAPYLRKFGQFTVPDFIGERYY 112
Cdd:pfam00474 1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 113 SKTA-RMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMGIVFFYAVLGGMKGITYTQVAQFCVLIFAFLV 191
Cdd:pfam00474 81 GKRIlVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 192 PAIFTSIMMTG-NPLPQVGMGSTLSGTDVYLLDKLDGLteelgftaytegnKSMVDVFFICAALMVGTAGLPHVIIRFFT 270
Cdd:pfam00474 161 LMIIVFHEVGGySSAVEKYMTADPNGVDLYTPDGLHIL-------------RDPLTGLSLWPGLVLGTTGLPHILQRCLA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 271 VPKVRDARISAGWALLFISLLYttaPGvaafarvnMIETINGPDMQGVAAADApswyknwestglVGWEDKNGDgkmfys 350
Cdd:pfam00474 228 AKDAKCIRCGVLILTPMFIIVM---PG--------MISRGLFAIALAGANPRA------------CGTVVGCSN------ 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 351 gdernemkinrdiivLASPELAK--LPNWVVALLAAGGLAAALSTAAGLLLVISTSISHDLLKKGFRPNM-TDKQELLAA 427
Cdd:pfam00474 279 ---------------IAYPTLAVklGPPGLAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKASaTEKELVGRS 343
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1715703716 428 RLAAMVAIVGAGYLGINPP-GFVAQVVAFAFGLAAASFFPAIILGIFYKKMNKEGAIAGMLSG 489
Cdd:pfam00474 344 RIIVLVVISLAILLAVQPAqMGIAFLVQLAFAGLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406
|
|
| PRK12488 |
PRK12488 |
cation/acetate symporter; |
6-491 |
1.11e-37 |
|
cation/acetate symporter;
Pssm-ID: 237114 [Multi-domain] Cd Length: 549 Bit Score: 146.48 E-value: 1.11e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 6 WTFILVGITFAVY-IGIAIWA--RAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYLMGWTG 82
Cdd:PRK12488 32 WTAIGMFMVFVLFtLGITRWAarRTRSASDFYTAGGGLTGMQNGLAIAGDMISAASFLGISAMMFMNGYDGLLYALGVLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 83 GYVLLALCLAPYLRKFGQFTVPDFIGERYYSKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMGIV 162
Cdd:PRK12488 112 GWPIILFLIAERLRNLGKYTFADVVSYRLAQGPVRLTAAFGTLTVVLMYLVAQMVGAGKLIELLFGISYLYAVVIVGALM 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 163 FFYAVLGGMKGITYTQVAQFCVLIF-----AFLVPAIF--TSIMMTGNPLPQVGMGSTLSGTDVYLLDKLDGLTEELGft 235
Cdd:PRK12488 192 VLYVTFGGMLATTWVQIIKAVLLLSgtsfmAFMVLKHFgfSTEAMFASAVAVHAKGQAILAPGGLLSNPIDAISLGLG-- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 236 aytegnksmvdvfficaaLMVGTAGLPHVIIRFFTVPKVRDARISAGWALLFISLLYTTAPgVAAFARVNMietingpdm 315
Cdd:PRK12488 270 ------------------MMFGTAGLPHILMRFFTVSDAREARKSVLYATGFIGYFYLLII-VVGFGAIVM--------- 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 316 qgvaaadapswyknwestglVGWEDKNGD--GKMFYSGDernemkinrdiIVLASPELAKLPNWVVALLAAGGLAAALST 393
Cdd:PRK12488 322 --------------------VGTEPSYRDagGKIIGGGN-----------MVAVHLAQAVGGNLFLGFISAVAFATILAV 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 394 AAGLLLVISTSISHDLLKKGFRP-NMTDKQELLAARLAAMVAIVGAGYLGInppGFVAQVVAF----AFGLAAASFFPAI 468
Cdd:PRK12488 371 VAGLALSGASAVSHDLYACVIRKgQASEAQEMRVSKIATLGIGLLAVVLGL---MFESQNIAFlsglVLAIAASVNFPVL 447
|
490 500
....*....|....*....|...
gi 1715703716 469 ILGIFYKKMNKEGAIAGMLSGIA 491
Cdd:PRK12488 448 FLSMFWKGLTTRGAVAGSYAGLV 470
|
|
| actP |
PRK09395 |
cation/acetate symporter ActP; |
8-491 |
3.39e-35 |
|
cation/acetate symporter ActP;
Pssm-ID: 236495 Cd Length: 551 Bit Score: 139.34 E-value: 3.39e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 8 FILVGITfavyIGIAIWA--RAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYLMGWTGGYV 85
Cdd:PRK09395 41 LIFVVFT----LGITYWAakRTRSASDFYTAGGGITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWP 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 86 LLALCLAPYLRKFGQFTVPDFIGERYYSKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMGIVFFY 165
Cdd:PRK09395 117 IILFLIAERLRNLGKYTFADVASYRLKQGPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVVLVGVLMMVY 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 166 AVLGGMKGITYTQVAQFCVLifafLVPAIFTSIMMtgnpLPQVGMG-STLSGTDVYLLDKLDGLTEELGFTaytegnKSM 244
Cdd:PRK09395 197 VLFGGMLATTWVQIIKAVLL----LSGATFMAFMV----MKHVGFSfENLFSEAVAVHPKGLAIMGPGGLV------KDP 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 245 VDVFFICAALMVGTAGLPHVIIRFFTVPKVRDARISAGWALLFISLLY--TTAPGVAAFARVN--------MIETINGPD 314
Cdd:PRK09395 263 ISALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYilTFIIGFGAIVLVGtnpefkdaAGALIGGNN 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 315 MQGVAAADApswyknwestglVGwedkngdGKMFYSgdernemkinrdiiVLASPELAKLpnwvvallaagglaaaLSTA 394
Cdd:PRK09395 343 MAAVHLANA------------VG-------GNLFLG--------------FISAVAFATI----------------LAVV 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 395 AGLLLVISTSISHDL----LKKGfrpNMTDKQELLAARLAAMVAIVGAGYLGInppGFVAQVVAF----AFGLAAASFFP 466
Cdd:PRK09395 374 AGLTLAGASAVSHDLyanvIKKG---KATERDELRVSKITTLVLGVVAIILGI---LFEKQNIAFmvglAFAIAASANFP 447
|
490 500
....*....|....*....|....*
gi 1715703716 467 AIILGIFYKKMNKEGAIAGMLSGIA 491
Cdd:PRK09395 448 VLLLSMYWKGLTTRGAVIGGWLGLI 472
|
|
| PanF |
COG4145 |
Na+/panthothenate symporter [Coenzyme transport and metabolism]; |
1-552 |
7.15e-32 |
|
Na+/panthothenate symporter [Coenzyme transport and metabolism];
Pssm-ID: 443316 Cd Length: 484 Bit Score: 128.80 E-value: 7.15e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 1 MDIQTWTFILvgITFAVYIGIAIWAR-----AGSTSEFYVAGGGVHPVANGMATAADWMSAASFIsmagiisfvGYDGAV 75
Cdd:COG4145 2 MNLAILIPLL--IYLLLVLGIGIYASrkrskGSFLEEYFLGSRSMGGFVLAMTLAATYTSASSFI---------GGPGAA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 76 YLMGWtgGYVLLALC---------------LAPYLRKFGQFTVPDFIGERYYSKTARMVAVFCAIFVSFTYVAGQMRGVG 140
Cdd:COG4145 71 YKYGL--GWVLLAMIqvptafltlgvlgkkFAILGRKYNAVTLADWLRARYQSKALVLLAALLLLLFFIAFMVAQFVGGA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 141 VVFSRFLEVDINLGIIIGMGIVFFYAVLGGMKGITYTQVAQFCVLIFAFLVpaIFTSIMMTGNPLPQvgmgstlsgtdvy 220
Cdd:COG4145 149 RLLETVTGISYTTGLLIFGVTVVLYTTIGGFRAVVLTDAIQGIIMLVGTVL--LLIGVISAGGGIEN------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 221 LLDKLDGLTEELGFTAYTEGN--KSMVDVFFIcaALMVGTAGLPHVIIRFFTVPKVRDARISAGWALLFISLLYTTAPGV 298
Cdd:COG4145 214 IMSTLAAIDPNLVSPTGPDGFlpRPFVISFWI--LVGFGVIGLPHTAVRCMAYKDSKSLHRAMIIGTIVVGLLMFGMHLI 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 299 AAFARvnmietingPDMQGVAAADApswyknwestglvgwedkngdgkmfysgdernemkinrdiiVLASPELAKLPNWV 378
Cdd:COG4145 292 GVLGR---------AVLPDLTVPDQ-----------------------------------------VIPTLMVKVLPPFL 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 379 VALLAAGGLAAALSTAAGLLLVISTSISHDLLKKGFRPNMT--DKQELLAARLAAMVAIVGAGYLGINPPGFVAQVVAFA 456
Cdd:COG4145 322 AGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLNYINPKASenEKKLKRLSKLVTLVLGLIVFLLALNPPDLIIWLNLFA 401
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 457 FGLAAASFFPAIILGIFYKKMNKEGAIAGMLSGIAFTasyiIYFKFINPAastpenwWFGISPEgigTLGMCLNFVVSIA 536
Cdd:COG4145 402 FGGLEAAFFWPLVLGLYWKRANATGAIASMLVGVASY----FLLYYGNPK-------IFGFHAI---VPSLLISLIAFLI 467
|
570
....*....|....*.
gi 1715703716 537 VNKVTAEVPQDVQDMV 552
Cdd:COG4145 468 GSLLGKPPDEERLELF 483
|
|
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
9-491 |
3.02e-23 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 102.99 E-value: 3.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 9 ILVGITFAVYIGIAIWA--RAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYdGAVYLMGWtgGYvl 86
Cdd:cd11474 2 IGVILYYLLILGIGLWAsrRVKSSEDFLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGL-GGVAQDPF--GY-- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 87 lALCL-------APYLRKFGQFTVPDFIGERYySKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGM 159
Cdd:cd11474 77 -ALCLilgglffAKPMRRMGLLTLGDFFRQRY-GRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPVETGILISA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 160 GIVFFYAVLGGMKGITYTQVAQFCVLIFAFLVPAIFTSIMmtgnplpqVGMGSTLSGTDVYLLDKLDGLTEELGFtayte 239
Cdd:cd11474 155 AIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTN--------PGGVDIASAAAAGKLRFFPWLGTKSDW----- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 240 gnksmvdVFFICAALMVGTAGLPH--VIIRFFTvpkVRDARIsAGWALLFISLLYTTAPGVAAFArvnmietingpdmqG 317
Cdd:cd11474 222 -------LIWIDAWLTLGLGSIPQqdVFQRVLS---AKSEKT-AQRLSLLAGVGYLLFAIPPLLI--------------G 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 318 VAAADApswykNWESTGLVGWEDKNgdgkmfysgdernemkinrdiIVLasPELAK--LPNWVVALLAAGGLAAALSTAA 395
Cdd:cd11474 277 LAAASI-----DPSLTQYGLEEDAQ---------------------LIL--PLLLQylTPLWVQVLFLGALLSAVMSTAD 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 396 GLLLVISTSISHDLLKKGFRPNMTDKQELLAARLAAMVAIVGAGYLGINPPGfVAQVVAFAFGLAAASFFPAIILGIFYK 475
Cdd:cd11474 329 SALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTVES-IYGLVELASDLVLVGLFVPLLAGLYWK 407
|
490
....*....|....*.
gi 1715703716 476 KMNKEGAIAGMLSGIA 491
Cdd:cd11474 408 RANTYGALAAIIVGLV 423
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
7-545 |
1.25e-19 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 91.88 E-value: 1.25e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 7 TFILVGITFAVYIGIAIWARAGS-------TSEFYVAGGGVHPVANGMATAADWMSAASFIsmagiisfvGYDGAVYLMG 79
Cdd:cd10327 1 VLLPIIIYLVILLGIGFYARRSKkrrsgdfLEEYFIGGRSMGGFVLAMTLVATYTSASSFI---------GGPGAAYKIG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 80 WtgGYVLLALCLAP--YL-------------RKFGQFTVPDFIGERYYSKTARMVAVFCAIFVSFTYVAGQMRGVGVVFS 144
Cdd:cd10327 72 L--GWVLLAMIQVPtgFLtlgvlgkkfaiiaRKINAVTIIDYLRARYNSKALVVLSSLALIVFFIAAMVAQFIGGARLLE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 145 RFLEVDINLGIIIGMGIVFFYAVLGGMKGITYTQVAQFCVLIFAFLVpaIFTSIMMTGNplpqvGMGSTLSGtdvyLLDK 224
Cdd:cd10327 150 AVTGLSYVTGLLIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGTVL--LLVGVLAAGG-----GMEAIMAT----LAEI 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 225 LDGLTEELGFTAYTegnKSMVDVFFICaaLMVGTAGLPHVIIRFFTVPKVRDARISAGWALLFISLLYTTAPGVAAFARV 304
Cdd:cd10327 219 DPNLLTPFGPGFLS---PPYILSFWVL--VGFGVIGLPQTAVRCMGYKDSKSMHRAMIIGTVVVGFLMLGMHLAGVLGRA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 305 nMIETINGPDMqgvaaadapswyknwestglvgwedkngdgkmfysgdernemkinrdIIVLASPELakLPNWVVALLAA 384
Cdd:cd10327 294 -VLPDLEVPDK-----------------------------------------------VIPTLALKV--LPPWLAGLFLA 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 385 GGLAAALSTAAGLLLVISTSISHDLLK--KGFRPNMTDKQellAARLAAMV-AIVGAG--YLGINPPGFVAQVVAFAFGL 459
Cdd:cd10327 324 GPLAAIMSTVDSQLILASSAIVKDLYLnyKNKEKKTSEKK---VKRISLIItIILGLLvfLLAINPPDLIVWLNLFAFGG 400
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 460 AAASFFPAIILGIFYKKMNKEGAIAGMLSGIaftASYIIYFKFINPaastpenwWFGISPEGIGTLgmcLNFVVSIAVNK 539
Cdd:cd10327 401 LEAAFFWPLVLGLYWKRANATGALASMVVGL---VSYILITYLKIK--------ILGLHPIVPSLL---LSLIAFIIVSL 466
|
....*.
gi 1715703716 540 VTAEVP 545
Cdd:cd10327 467 ATKKPD 472
|
|
| SLC5sbd_u1 |
cd11477 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
8-562 |
3.85e-18 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271371 Cd Length: 493 Bit Score: 87.25 E-value: 3.85e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 8 FILVGITFAVYIGIAIWAR---AGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYLMGWTGGY 84
Cdd:cd11477 3 WLVIALYFLLMLGIGLWFSkraSKSTSDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWWLWAVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 85 VLLALCLAPYLRKFGQFTVPDFIGERY---YSKTARMVAVFCAIFVSFTYVAGQMRGVGVVFS-RFLEVDINLGIIIGMG 160
Cdd:cd11477 83 LIGAFVFARRWRRLRVLTDGEFPEERYggrYGAPLRQFYAVYFALLSNVDILAWVFLAAIKVSaVFGPWDPWLTILILGL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 161 IVFFYAVLGGMKGITYTQVAQFCVLIFAFLVPAIFTsimmtgnpLPQVGMGSTlsgtdvyLLDKLDGLTEELGFTAYTEG 240
Cdd:cd11477 163 ITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLA--------LNAVGGPGG-------LFAQLPEGHLDLFGSGLGAS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 241 NKSMVDVFFICAALMVGTA--GLPHVIIRFFTVPKVRDARISAGW--ALLFISLLYTTAPGVAAFARVNMIETINGPDMQ 316
Cdd:cd11477 228 GFYITFFFILFFGWYPLSYsgGGWYLAQRYLSAKSEKAAKAAAWLfaALYLVRPWPWMLPALAALVLYPDLDDPEADFEL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 317 GVAAAdapswYKNWESTGLVGwedkngdgkmfysgdernemkinrdiIVLASpelaklpnwvvallaagGLAAALSTAAG 396
Cdd:cd11477 308 AYPMM-----IKEYLPAGLLG--------------------------LVLAG-----------------LLAATMSTVST 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 397 LLLVISTSISHDLLKKGFRPNMTDKQELLAARLAAMVAIVGAGYLGINPP--GFVAQVVAFAFGLAAASFFPAIILGIFY 474
Cdd:cd11477 340 HLNWGAAYLVNDIYKRFIKPNASEKHLLKVGRLATVLFGLLSIVVALASDsiGGAFWIVLALGAGLGGPLILPWLWWRFN 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 475 KKMNKEGAIAGMLSGIAFTASYIIYFKFINPAASTPenWWFGISpegigtlgmclnFVVSIAVNKVTAEVPQDVQDMVEN 554
Cdd:cd11477 420 AWTEIWAMIASIIVGLVVSVLLKVFGLPEDFLFSFL--VPVLLS------------LVVWLAVTLLTPPTDEETLVAFYK 485
|
....*...
gi 1715703716 555 IRYPKGAG 562
Cdd:cd11477 486 KVRPWGFW 493
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
8-510 |
5.40e-15 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 77.26 E-value: 5.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 8 FILVGITFAVYIGIAIWA--RAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAvYLMGWTG-GY 84
Cdd:cd11479 3 YGVIALYFAAMIAIGWWGmrRAKTSEDYLVAGRRLGPGLYLGTMAAVVLGGASTIGGVGLGYQYGISGM-WLVVAIGlGI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 85 VLLALCLAPYLRKFGQFTVPDFIGERYYSKTARMVAVFCAIFVsFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMGIVFF 164
Cdd:cd11479 82 LALSLLLAKRIARLKVYTVSEVLELRYGPSARVISALVMLAYT-LMVAVTSTIAIGTVFSVLFGLPRTLSILVGGGIVVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 165 YAVLGGMKGITYTQVAQFCVL---IFAFLVPAiftSIMMTGNplpqvgmgstlsgtdvylldkLDGLTEELG---FTAYT 238
Cdd:cd11479 161 YSVLGGMWSITLTDIIQFVIKtigIFLLLLPL---ALSKAGG---------------------LSGLQEKLPasyFDLTS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 239 EGNKSMVDVFFI-CAALMVGTaglpHVIIRFFTVPKVRDARiSAGWALLFISLLYttapGVAAfARVNMIETINGPDMQg 317
Cdd:cd11479 217 IGWDTIVTYFLLyFFGILIGQ----DIWQRVFTARSEKVAR-WGGVAAGLYCVLY----GVAG-ALIGMAAAVLLPDLA- 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 318 vaaadapswyknwestglvgwedkNGDGkmfysgdernemkinrdiiVLASPELAKLPNWVVALLAAGGLAAALSTAAGL 397
Cdd:cd11479 286 ------------------------NPQN-------------------AFATMAQEVLPVGLRGLVLAAALAAMMSTASGA 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 398 LLVISTSISHDLLKKGFRPNMTDKQELLAARLaaMVAIVGAGYLGInpPGFVAQVVA---FAFGLAAASFFPAIILGIFY 474
Cdd:cd11479 323 LLASSTVLTNDVLPRLRRKNESERSEVRLSRL--FTLLLGVVVIVI--AVLVNDVVAaltIAYAILVGGLLVPILGGLFW 398
|
490 500 510
....*....|....*....|....*....|....*.
gi 1715703716 475 KKMNKEGAIAGMLSGIAFTASYIIYFkfiNPAASTP 510
Cdd:cd11479 399 KRATGAGALASMVAGSVVVLAGMAVD---GLLANTP 431
|
|
| SLC5sbd_SGLT1-like |
cd10329 |
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
8-195 |
3.65e-14 |
|
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271363 Cd Length: 538 Bit Score: 75.30 E-value: 3.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 8 FILVGITFAVYIGIAIWA---RAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIisfvGYDG--AVYLMGWTG 82
Cdd:cd10329 1 IVIIAVYFVAVIAIGLWSsrkKRSTVSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGS----GAASgiAVGNYEWNA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 83 GYVLLALCL--APYLRKFGQFTVPDFIGERYYSKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMG 160
Cdd:cd10329 77 AFVLLLLGWvfLPFYIRSGVSTMPEFLEKRFGGRSRVYLSVLSLILYVFTKISVDLYAGALVIKQLLGWDLYLSIIVLLV 156
|
170 180 190
....*....|....*....|....*....|....*
gi 1715703716 161 IVFFYAVLGGMKGITYTQVAQFCVLIFAFLVPAIF 195
Cdd:cd10329 157 ITAIYTIAGGLKAVIYTDTLQAVILIIGSAILMFL 191
|
|
| PRK15419 |
PRK15419 |
sodium/proline symporter PutP; |
13-489 |
4.67e-13 |
|
sodium/proline symporter PutP;
Pssm-ID: 185317 Cd Length: 502 Bit Score: 71.59 E-value: 4.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 13 ITFAVYI------GIAIWARAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYLMGWTGGYVL 86
Cdd:PRK15419 9 VTFCVYIfgmiliGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISESWIAIGLTLGAWI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 87 LALCLAPYLRKFGQF-----TVPDFIGERY--YSKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGM 159
Cdd:PRK15419 89 NWKLVAGRLRVHTEYnnnalTLPDYFTGRFedKSRILRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 160 GIVFFYAVLGGMKGITYTQVAQFCVLIFAFLVPAIFTsIMMTGnplpqvGMGSTLSGTDVYLLDKLDGLtEELGFTAYTe 239
Cdd:PRK15419 169 AATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIV-IISVG------GFGDSLEVIKQKSIENVDML-KGLNFVAII- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 240 gnksmvdvfficaALM---VGTAGLPHVIIRFFTVPK----VRDARISAGWALLfiSLLYTTAPGVAAFARVNmietiNG 312
Cdd:PRK15419 240 -------------SLMgwgLGYFGQPHILARFMAADShhsiVHARRISMTWMIL--CLAGAVAVGFFGIAYFN-----EH 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 313 PDMQGVAAADApswyknwestglvgwedkngdgkmfysgdERNEMKINRdiiVLASPelaklpnWVVALLAAGGLAAALS 392
Cdd:PRK15419 300 PAVAGAVNQNA-----------------------------ERVFIELAQ---ILFNP-------WIAGILLSAILAAVMS 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 393 TAAGLLLVISTSISHDLLKKGFRPNMTDKQELLAARLAAMVAIVGAGYLGINPPGFVAQVVAFAFGLAAASFFPAIILGI 472
Cdd:PRK15419 341 TLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGRVMVLVVALVAIALAANPENRVLGLVSYAWAGFGAAFGPVVLFSV 420
|
490
....*....|....*..
gi 1715703716 473 FYKKMNKEGAIAGMLSG 489
Cdd:PRK15419 421 MWSRMTRNGALAGMIIG 437
|
|
| SLC5sbd_u2 |
cd11478 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
6-547 |
1.90e-12 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271372 Cd Length: 496 Bit Score: 69.62 E-value: 1.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 6 WTFILVGITFAVYIGIAIWARAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGiiSFVGYDGAVYLMGWTG--- 82
Cdd:cd11478 3 YLIVAVYFVFVLGIGFYLKRKVKTSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSA--NGAQYGIATVHFYWIGaip 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 83 GYVLLALCLAPYLRKFGQFTVPDFIGERYYSKTARMVAVFCAIFvsFTYVAG-QMRGVGVVFSRFLEVDINLGIIIGMGI 161
Cdd:cd11478 81 AMVFLGIVMMPFYYGSKVRSVPEYLKLRFNKSTRLLNAVSFAVM--TILMSGiNLYALALVLNVLLGWPLWLSIILSAAI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 162 VFFYAVLGGMKGITYTQVAQFcVLIFAFLVPAIFTSIMMTGnplpqvGMGSTLSGTDVYLLDKLDGLTEELGFTAYTEGN 241
Cdd:cd11478 159 VLAYTTLGGLTSAIYNEVLQF-FLIVAGLIPLVIIGLIKVG------GWDGLSEKIDANGPPGWNGLSWGPQGSQSTNPM 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 242 KSMVDVFFICAALM-VGTAGLPHVII-RFFTVPKVRDAR---ISAGWALLFISLLyTTAPGVAAFARVNMIETINGPDmq 316
Cdd:cd11478 232 GVNLGLVFGLGFVLsFGYWTTNFLEVqRAMAAKDLSAARrtpLIAAFPKMFIPFL-VILPGLIALVLVPELGASGGLD-- 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 317 gvaaadapswyknwestglvgwedkngdgkmfysGDErnemkinrdiivlASPELAK--LPNWVVALLAAGGLAAALSTA 394
Cdd:cd11478 309 ----------------------------------YNQ-------------ALPYLMAkyLPPGLLGLGITALLAAFMSGM 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 395 AGLLLVISTSISHDLLKKGFRPNMTDKQELLAARLAAMVAI---VGAGYLGINPPGfVAQVVAFAFGLAAASFFPAIILG 471
Cdd:cd11478 342 AGNVSAFNTVFTYDIYQTYIVKDAPDKHYLKVGRIATVVGVlisIGTAYIASSFNN-IMDYLQLLFSFFNAPLFATFLLG 420
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1715703716 472 IFYKKMNKEGAIAGMLSGIAFTASYII--YFKFINPAASTPENWWFGIspegigtLGMCLNFVVSIAVNKVTAEVPQD 547
Cdd:cd11478 421 MFWKRATPWGGFWGLLAGTASAIVLYGlyELGLIVYHSDMAPNFYGAW-------WAFVVCFVVTVLVSLLTKPKPEK 491
|
|
| panF |
TIGR02119 |
sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is ... |
13-507 |
3.48e-11 |
|
sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is made from aspartate and 2-oxoisovalerate in most bacteria with completed genome sequences. However, some pathogens must import pantothenate. This model describes PanF, a sodium/pantothenate symporter, from a larger family of Sodium/substrate symporters (pfam00474). Several species that have this transporter appear to lack all enzymes of pantothenate biosynthesis, namely Haemophilus influenzae, Pasteurella multocida, Fusobacterium nucleatum, and Borrelia burgdorferi. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A, Transport and binding proteins, Other]
Pssm-ID: 131174 Cd Length: 471 Bit Score: 65.52 E-value: 3.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 13 ITFAVYIGIAIWAR------AGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGydgavylMGW------ 80
Cdd:TIGR02119 9 IYLVTVFLIAIYASkrvqstDSFLNEYFLGGRSMGGFVLAMTLVATYGSASSFIGGPGIAYNYG-------LGWvllami 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 81 ---TGGYVLLALC--LAPYLRKFGQFTVPDFIGERYYSKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGI 155
Cdd:TIGR02119 82 qvpTGYFVLGVLGkkFAIISRKYNAITINDVLKARYNNKFLVWLSSISLLVFFFSAMVAQFIGGARLIESLTGLSYLTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 156 IIGMGIVFFYAVLGGMKGITYTQVAQFCVLIFAFLVpaIFTSIMMTGNPLPQVGMgsTLSGTDVYLLDKldglteelgFT 235
Cdd:TIGR02119 162 FIFSSSVLIYTTFGGFRAVALTDAIQGIVMFTGTTI--LLIAVIKAGGGVEKIME--KLKDIDPNLITP---------FG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 236 AYTEGNKSMVDVFFICAAlmVGTAGLPHVIIRFFTVPKVRDARISAGWALLFISLLYTTAPGVAAFARVNMietingPDM 315
Cdd:TIGR02119 229 GDGGLTKPFVASFWILVG--IGVIGLPQTAVRCMSYKDSKAMHRAMIIGTIVVGIIMLGMHLAGVLGRAVI------PDL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 316 QGVaaadapswyknwestglvgweDKngdgkmfysgdernemkinrdiiVLASPELAKLPNWVVALLAAGGLAAALSTAA 395
Cdd:TIGR02119 301 TVP---------------------DK-----------------------VIPLLAIKVLPPILAGIFLAAPMAAIMSTVN 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 396 GLLLVISTSISHDLLKKGFRPNMTDKQELLAARLAAMVAIVGAGYLGINPPGFVAQVVAFAFGLAAASFFPAIILGIFYK 475
Cdd:TIGR02119 337 SLLLQSSSTIIKDLYLNYIPKEAKESKIKKISMCITLIIGLLVIIAAIKPPDLIIWLNLFAFGGLEAAFIWPIVLGLYWK 416
|
490 500 510
....*....|....*....|....*....|...
gi 1715703716 476 KMNKEGAIAGMLSGIaftASYIIYFKF-INPAA 507
Cdd:TIGR02119 417 RANATGALASMIVGV---GSYITLESFkPKIFG 446
|
|
| SLC5sbd_NIS-like_u3 |
cd11495 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
6-505 |
2.85e-10 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271386 [Multi-domain] Cd Length: 473 Bit Score: 62.56 E-value: 2.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 6 WTFILVGITFAVYIGIAIWARAGSTSEFYVAGGGVHPVANGMATAADWMSAasfismagiISFVGYDGAVYLMGWTGGYV 85
Cdd:cd11495 6 YLVLVIYLLAMLGIGLYFSKKQKSTDDYFKGGGRIPWWAAGLSIFATTLSS---------ITFLAIPGKAYATDWNYFVG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 86 LLALCLA---------PYLRKFGQFTVPDFIGERYySKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLgII 156
Cdd:cd11495 77 SLSIIIAaplaayffvPFFRRLNVTSAYEYLEKRF-GPWARVYGSLLFILFQLGRMGIVLYLPALALSAVTGINPYI-II 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 157 IGMGI-VFFYAVLGGMKGITYTQVAQFCVLIFAFLVPAIFTSIMMTGnplpqvGMGSTLSgtDVYLLDKLDGLTEELGFT 235
Cdd:cd11495 155 ILMGVlCIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIPG------GFGEVFD--IAIANGKFSLGDFSFSLT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 236 AYTEGnksMVDVFFICAALMVGTAGlPHVIIRFFTVPKVRDARIS---AGWALLFISLLYTTApGVAAFARVnmieTING 312
Cdd:cd11495 227 ESTIW---VIFIGGIFNNLQSYTSD-QDVVQRYLTTKSIKEAKKSlwtNALLALPVALLFFGI-GTALYVFY----QQHP 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 313 PDMQGVAAADA--PSWYKNWESTGLVGwedkngdgkmfysgdernemkinrdiIVLASPELAklpnwvvallaagglaaA 390
Cdd:cd11495 298 ELLPAGINGDAvfPYFIVTQLPVGVAG--------------------------LIIAAIFAA-----------------A 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 391 LSTAAGLLLVISTSISHDLLKKgFRPNMTDKQELLAARLAAMVA----IVGAGYLGINPPGFVAQVVAFAFGLAAASFFP 466
Cdd:cd11495 335 MSTISSSLNSVATCITTDFYKR-LSPDPSDKQYLKVARLITLLVgllgTLVALYLANAGVKSLLDAFNTLTGLFGGGLAG 413
|
490 500 510
....*....|....*....|....*....|....*....
gi 1715703716 467 AIILGIFYKKMNKEGAIAGMLSGIAFTASYIIYFKFINP 505
Cdd:cd11495 414 LFLLGIFTKRANAKGALVGIIVSIIVIFWISLLYTPIHF 452
|
|
| SLC5sbd_NIS-like_u2 |
cd11494 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
8-492 |
8.62e-10 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 61.08 E-value: 8.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 8 FILVGITFAVYIGIAIWARAGSTS--EFYVAGGGVHPVANGMATAADWMSAASFISMAGiisFVGYDGavylMGWTGGY- 84
Cdd:cd11494 3 WIVLVGYLLGILVYGVYKGRGQKNqeDYFLGGRSMPWWPIGLSIMATQASAITFLSAPG---QAYSDG----MRFVQYYf 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 85 ----VLLALCLA--PYLRKFGQFTVPDFIGERYYSKTaRMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIG 158
Cdd:cd11494 76 glplAMIFLCITfvPVFYKLKVYTAYEYLERRFGLKT-RLLTSILFLISRGLATGVTIYAPAIILSTILGWSLWLTILLI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 159 MGIVFFYAVLGGMKGITYTQVAQFCVLIFAFLVPAIFTSIMmtgnpLPQVGMGSTLSGTDVYLLDKLD---GLTEELGFT 235
Cdd:cd11494 155 GGITIIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKL-----LPVGFVDALLVAGKSGRLNALDfsfDLSDTYTFW 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 236 AYTEGNKSMVDVFFICAALMVGtaglphviiRFFTVPKVRDARIS---AGWALLFISLLYTTApGVAAFArvnmieting 312
Cdd:cd11494 230 SGLIGGFFLYLSYFGTDQSQVQ---------RYLTAKSIKEARKSlllNGFLKFPMQFFILLI-GVLVFV---------- 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 313 pdmqgvaaadapsWYKNWESTglvgwedkngdgkMFYSGDERNEMKINRDIIVLAspeLAKLPNWVVALLAAGGLAAALS 392
Cdd:cd11494 290 -------------FYQFNPFP-------------VSFNPAEDETKDTNYIFLRFV---LNYLPPGVIGLLIAAIFAAAMS 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 393 TAAGLLLVISTSISHDLLKKGFRPNMTDKQELLAARLAAMV----AIVGAGYLGINPP--GFVAQVVAFAFGLAAASFFp 466
Cdd:cd11494 341 SIDSALNSLATVTVIDIYRRFFKKDASDEHYLKVSRLLTVFwgllAIVFALFAGLAGSliEAVNKLGSLFYGPILGVFL- 419
|
490 500
....*....|....*....|....*.
gi 1715703716 467 aiiLGIFYKKMNKEGAIAGMLSGIAF 492
Cdd:cd11494 420 ---LAFFTKKANGKGVFAGAILGVIV 442
|
|
| SLC5sbd_NIS-like |
cd10326 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
8-203 |
8.92e-08 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271361 [Multi-domain] Cd Length: 472 Bit Score: 54.87 E-value: 8.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 8 FILVGITFAVYIGIAIWA--RAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIisfVGYDGAVYLM---GWTG 82
Cdd:cd10326 2 WAVVVVYFLILLAISYYTsrRNADNDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGE---VGGSGFTYLQmvlGFLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 83 GYVLLALCLAPYLRKFGQFTVPDFIGERYySKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFL----EVDINLGIIIG 158
Cdd:cd10326 79 GYLIIAFVLLPLYYRLNLTSIYEYLEDRF-GVSSRKTGAVFFLLSRILGAGIRLYLVALVLQQFLfdslGIPFWLTVLIT 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1715703716 159 MGIVFFYAVLGGMKGITYTQVAQFCVLIFAFLVPAIFTSIMMTGN 203
Cdd:cd10326 158 GLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGLG 202
|
|
| SLC5sbd_vSGLT |
cd10325 |
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
9-191 |
1.58e-06 |
|
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271360 Cd Length: 523 Bit Score: 50.77 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 9 ILVGITFAVYIGIAIWAR------AGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYlmGWTG 82
Cdd:cd10325 1 VIFIVYVILIIGLGLWVSrekkggEKDATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGLAIASY--EWMA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 83 GYVLL--ALCLAPYLRKFGQFTVPDFIGERYYSKTARMVAVF---CAIFVSFTYVA--GqmrgvGVVFSRFLEVDINLGI 155
Cdd:cd10325 79 AITLIivAKFFLPIFLKNGIYTMPQFLEERYDGRVRTIMAVFwllLYVFVNLTSVLylG-----ALAIETITGIPLTYSI 153
|
170 180 190
....*....|....*....|....*....|....*.
gi 1715703716 156 IIGMGIVFFYAVLGGMKGITYTQVAQFCVLIFAFLV 191
Cdd:cd10325 154 IGLALFAAAYSIYGGLKAVAWTDVIQVVFLVLGGLV 189
|
|
| SLC5sbd_SGLT5 |
cd11489 |
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ... |
9-194 |
4.25e-06 |
|
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212058 Cd Length: 604 Bit Score: 49.55 E-value: 4.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 9 ILVGITFAVYIGIAIW----ARAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGiisfVGYDGAVYLMG--WTG 82
Cdd:cd11489 6 IVIGVYFALNVAVGIWsscrVSRNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAG----TGAAGGIAVAGfeWNA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 83 GYVLLALC--LAPYLRKFGQFTVPDFIGERYYSKTARM-VAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGM 159
Cdd:cd11489 82 TYALLALAwvFVPVYISSGIVTMPEYLQRRFGGERIRMyLSVLSLLLSVFTKISTDLYSGALFVQVCLGWNLYLSTVLML 161
|
170 180 190
....*....|....*....|....*....|....*
gi 1715703716 160 GIVFFYAVLGGMKGITYTQVAQFCVLIFAFLVPAI 194
Cdd:cd11489 162 VVTALYTIAGGLAAVIYTDALQTLIMVIGAVILTI 196
|
|
| SLC5sbd_YidK |
cd10328 |
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ... |
68-192 |
8.16e-06 |
|
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271362 Cd Length: 472 Bit Score: 48.30 E-value: 8.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 68 FVGYDGAVYL-----MGWTG----GYVLLALCLAPYLRKFGQFTVPDFIGERYYSKTARMVAVFCAIFVSFTYVAGQMRG 138
Cdd:cd10328 53 LVGLNGQAYAlgmsvMAWEVtaaiALIILALVFLPRYLKGGITTIPEFLEERYDETTRRIVSILFLLGYVVILLPIVLYS 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1715703716 139 VGVVFSRFLEVDINLGI---------IIGMGIV-FFYAVLGGMKGITYTQ-VAQFCVLIFAFLVP 192
Cdd:cd10328 133 GALALNSLFDVSELLGIsyfqalwllVWLIGIIgAIYAIFGGLKAVAVSDtINGVGLLIGGLLIP 197
|
|
| SLC5sbd_SGLT2 |
cd11487 |
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ... |
10-186 |
9.14e-06 |
|
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212056 [Multi-domain] Cd Length: 583 Bit Score: 48.38 E-value: 9.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 10 LVGITFAVYIGIAIW----ARAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYdgAVYLMGWTGGYV 85
Cdd:cd11487 5 VIAAYFLLVIGVGLWsmcrTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGI--AVAGFEWNALFV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 86 LLAL--CLAPYLRKFGQFTVPDFIGERYYSKTARM-VAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMGIV 162
Cdd:cd11487 83 VLLLgwLFVPVYLTAGVITMPQYLKKRFGGQRIRLyLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGIT 162
|
170 180
....*....|....*....|....
gi 1715703716 163 FFYAVLGGMKGITYTQVAQFCVLI 186
Cdd:cd11487 163 MIYTVTGGLAALMYTDTVQTFVII 186
|
|
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
8-492 |
1.45e-05 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 47.58 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 8 FILVGITFAVYIGIAIWARAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGiisfvgydgAVYLMGWTGGY--- 84
Cdd:cd11476 10 LFALLMVFITRLLKRYRGKNQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSAT---------VAYQYGVSGPFwya 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 85 ------VLLALCLAPYLRKF--GQFTVPDFIGERYySKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGII 156
Cdd:cd11476 81 sgatlqILLFAPLAIRIKRLapNAHTLLEIVRARY-GTAAHLVFLVFALFTNVIVLAMLLLGGSAVVNALTGMPIVAASF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 157 IGMGIVFFYAVLGGMKGITYTQVAQFCVL--IFAFLVPAIFTSimmtgnpLPQVGMGSTLsgtdvylldklDGLTEElGF 234
Cdd:cd11476 160 LIPLGVLLYTLFGGLRATFLTDYIHTVIIliILLVFAFAVYTS-------SDIGSPSKVY-----------DLLQEA-AP 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 235 TAYTEGNKSMVDVFFICAALMvgtAGLPHVIIRFFTV-------PKVRDARISAGWALLFISllyttapGVAAFARVNMI 307
Cdd:cd11476 221 DLPVEGNQGSYLTFKSKAGLI---FGIINIVGNFGTVfldqgywQRAIAARPSAAVKGYFLG-------GLAWFAIPFLL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 308 ETINGpdMQGVAAADAPSWyknwestglvgwEDKNGDgkmfysgdernemkinrdiIVLASPELAKLPNWVVALLAAGGL 387
Cdd:cd11476 291 ATTLG--LAALALGLNPTF------------EEVSAG-------------------LVLPYVAAALLGKGGAAAVLVLLF 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 388 AAALSTAAGLLLVISTSISHDLLKKGFRPNMTDKQELLAARLAAMVAIVGAG-------YLGINppgfVAQVVAFAFGLA 460
Cdd:cd11476 338 MAVTSTASAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIGFGLFMGglavglnYIGIS----LGWLLLFMGILI 413
|
490 500 510
....*....|....*....|....*....|..
gi 1715703716 461 AASFFPaIILGIFYKKMNKEGAIAGMLSGIAF 492
Cdd:cd11476 414 GSAVFP-VALGLYWRRQTGTAAVVSPIAGLVA 444
|
|
| SLC5sbd_SGLT1 |
cd11486 |
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ... |
13-209 |
1.83e-05 |
|
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.
Pssm-ID: 271379 Cd Length: 636 Bit Score: 47.62 E-value: 1.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 13 ITFAVYIGIAIWA----RAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGI-----ISFVGYDGAVYLMgwtgg 83
Cdd:cd11486 8 IYFVVVLAVGVWAmvstNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTgaaagIAIGGFEWNALVV----- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 84 YVLLALCLAPYLRKFGQFTVPDFIGERYYSKTARM-VAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMGIV 162
Cdd:cd11486 83 VVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVyLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLAIT 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1715703716 163 FFYAVLGGMKGITYTQVAQFCVLIFAflvpaiftSIMMTGNPLPQVG 209
Cdd:cd11486 163 ALYTITGGLAAVIYTDTLQTIIMVVG--------SFILMGFAFNEVG 201
|
|
| SLC5sbd_SGLT4 |
cd11488 |
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ... |
9-191 |
2.16e-05 |
|
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.
Pssm-ID: 271380 Cd Length: 605 Bit Score: 47.24 E-value: 2.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 9 ILVGITFAVYIGIAIW----ARAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYdgAVYLMGWTGGY 84
Cdd:cd11488 3 AVVVVYFVFVLAVGIWssirASRGTVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGAAGGL--AVGGFEWNAAW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 85 VLLAL--CLAPYLRKFGQFTVPDFIGERYYSKTARM-VAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMGI 161
Cdd:cd11488 81 VLIALgwIFVPVYIAAGVVTMPEYLKKRFGGQRIRIyMSVLSLILYIFTKISTDIFSGALFIQVSLGWNLYLSTVILLAV 160
|
170 180 190
....*....|....*....|....*....|
gi 1715703716 162 VFFYAVLGGMKGITYTQVAQFCVLIFAFLV 191
Cdd:cd11488 161 TALYTIAGGLTAVIYTDALQTVIMVIGAFV 190
|
|
| SLC5sbd_NIS-like_u1 |
cd11493 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
8-188 |
3.08e-05 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271384 [Multi-domain] Cd Length: 479 Bit Score: 46.82 E-value: 3.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 8 FILVGITFAVYIGIAIWA--RAGSTSEFYVAGGGVHPVANGMATAADWMSAASFISMAGiisfVGYDGAVYLMGWTGGYV 85
Cdd:cd11493 2 LAVIVLYLLGLPLLGLWLsgRQKSTADYFLGGRSMPWWAVCLSVVATETSTLTFLSIPG----LAYGGDLTFLQLALGYI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 86 L----LALCLAPYLRKFGQFTVPDFIGERYYSKTARMVavfcaifvSFTYVAGQMRGVGVvfsRFLEVDINLGIIIGMGI 161
Cdd:cd11493 78 LgriiVAFVLLPRYFRGEVVSAYELLGQRFGGGMQKTA--------SVTFLVTRLLADGV---RLFAAAIPVSMILGADG 146
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1715703716 162 VF---------------FYAVLGGMKGITYTQVAQFCVLIFA 188
Cdd:cd11493 147 VAlsyiasiliisvvtlLYTYFGGIRAVVWTDVIQLVVYIGG 188
|
|
| SLC5sbd_NIS-SMVT |
cd11492 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
6-194 |
9.21e-05 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271383 [Multi-domain] Cd Length: 522 Bit Score: 45.17 E-value: 9.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 6 WTFILVGITFAVYIGIAIW-----ARAGSTSEFYVAGGGVHPVANGMATAADWMSAasfismagiISFVGYDGAVYLMG- 79
Cdd:cd11492 1 VDYVVFVAMLLISAAIGIYfgffgGKQKTTEEYLLGGRNMSVFPVALSLIASFISG---------ITLLGTPAEIYYYGt 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 80 ---WTGGYVLLALCLAPYLrkfgqfTVPDFIG----------ERYYSKTARMvavfcaiFVSFTYVAGQMRGVGVV---- 142
Cdd:cd11492 72 qywLIVIAYVLVGPITAYI------FLPVFYNlqltsvyeylELRFNRRVRL-------LASFLFILQMLLYLPIViyap 138
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1715703716 143 ---FSRFLEVDINLgIIIGMGIV-FFYAVLGGMKGITYTQVAQFCVLIFAFLVPAI 194
Cdd:cd11492 139 alaLSQVTGINLHI-IILVVGIVcIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVII 193
|
|
| SLC5sbd_NIS |
cd11503 |
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ... |
6-204 |
2.16e-04 |
|
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271393 Cd Length: 535 Bit Score: 44.06 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 6 WTFILVGITFAVYIGIAIW---ARAG--STSEFYVAGGGVHPVANGMATAADWMSAASFISMAGIISFVGYDGAVYLMGW 80
Cdd:cd11503 1 WDYGVFAAMLLVSTGIGLFvglARGGqrSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 81 TGGYVLLALCLAPYLRKFGQFTVPDFIGERYySKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDINLGIIIGMG 160
Cdd:cd11503 81 LLNSLMTAVLFMPVFYRLGITSTYQYLEMRF-SRAVRLCGTLQFIVATMLYTGIVIYAPALILNQVTGLDIWASLFSTGI 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1715703716 161 IVFFYAVLGGMKGITYTQVAQFCVLIFAFLVPAIfTSIMMTGNP 204
Cdd:cd11503 160 ICTFYTTVGGMKAVIWTDVFQVVVMLSGFWAVLI-RGVILVGGP 202
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
68-174 |
7.52e-04 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 42.18 E-value: 7.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 68 FVGYDGAVY-----LMGWTGG----YVLLALCLAPYLRKFGQFTVPDFIGERYYSKTARMVAVFCAIFVSFTYVAGQMRG 138
Cdd:PRK10484 59 LVGLNGQAYasgmsVMAWEVTaaiaLIILALIFLPRYLKSGITTIPDFLEERYDKTTRRIVSILFLIGYVVSFLPIVLYS 138
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1715703716 139 VGVVFSRFLEVDINLGI---------IIGMGIV-FFYAVLGGMKGI 174
Cdd:PRK10484 139 GALALNSLFHVSELLGIsygaaiwllVWLIGIIgAIYAVFGGLKAV 184
|
|
| SLC5sbd_NIS-SMVT |
cd11492 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
401-494 |
3.13e-03 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271383 [Multi-domain] Cd Length: 522 Bit Score: 40.16 E-value: 3.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 401 ISTSISHDLLKKGFRPNMTDKQELLAARLaaMVAIVGAGYLGInppGFVAQV------VAFA-FGLAAASFFPAIILGIF 473
Cdd:cd11492 348 LAAVILEDFIKPFFKKKLSERQATNIMKL--LVVVFGLLCIGL---AFLVEKlggvlqLSLSiFGITGGPLLGIFTLGMF 422
|
90 100
....*....|....*....|.
gi 1715703716 474 YKKMNKEGAIAGMLSGIAFTA 494
Cdd:cd11492 423 FPWANSKGALVGLLVGLIFML 443
|
|
| SLC5sbd_SMCT2 |
cd11520 |
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 ... |
4-218 |
7.24e-03 |
|
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. Human SMCT2 (hSMCT2) is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, it is expressed in the apical membrane of the proximal convoluted tubule, along the entire length of the tubule (in contrast to the high-affinity monocarboxylate transporter SMCT1, belonging to a different family, which is limited to the S3 segment of the tubule). SMCT2 may initiate lactate absorption in the early parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT2 is expressed exclusively in Muller cells. Nicotine transport by hSMCT2 is inhibited by several non-steroidal anti-inflammatory drugs. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212089 [Multi-domain] Cd Length: 529 Bit Score: 39.06 E-value: 7.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 4 QTWTFILVGITFAVYIGI----AIWARAGSTSEFYVAGG---GVHPVAngMATAADWMSAASFISMAGIISFVGYDGAVY 76
Cdd:cd11520 5 VAWDYVVFAGLFLVSSGIgvffAIKERKKATSKEFLVGGrqmSCGPVA--LSLTASFMSAVTVLGTPAEVYRFGASFVLF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715703716 77 LMGWTGGYVLLALCLAPYLRKFGQFTVPDFIGERYySKTARMVAVFCAIFVSFTYVAGQMRGVGVVFSRFLEVDInLGII 156
Cdd:cd11520 83 FIAYTFVIIFTSELFLPVFYRSGITSTYEYLELRF-NKPVRYAATLIYIVQTILYTGVVVYAPALALNQVTGFDL-WGSV 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1715703716 157 IGMGIV-FFYAVLGGMKGITYTQVAQFCVLIFAFLVPAIFTSIMMTG--NPLPQVGMGSTLSGTD 218
Cdd:cd11520 161 FATGIVcTFYCTLGGLKAVVWTDAFQMVVMVVGFLTVLIQGSIHNGGftNVWETAYNGSRLNIFD 225
|
|
| |
