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Conserved domains on  [gi|1715740932|gb|TWD71571|]
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DOPA 4,5-dioxygenase [Vibrio crassostreae]

Protein Classification

DOPA 4,5-dioxygenase family protein( domain architecture ID 10556249)

DOPA (dihydroxyphenylalanine) 4,5-dioxygenase family protein similar to Amanita muscaria DOPA 4,5-dioxygenase, an extradiol dioxygenase that opens up the cyclic ring of DOPA between carbons 4 and 5 to produce an unstable seco-DOPA that rearranges non-enzymatically to betalamic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DOPA_dioxygen pfam08883
Dopa 4,5-dioxygenase family; This family of proteins are related to Swiss:P87064, a DOPA 4, ...
 2-104 3.15e-32

Dopa 4,5-dioxygenase family; This family of proteins are related to Swiss:P87064, a DOPA 4,5-dioxygenase that is involved in synthesis of betalain. DOPA-dioxygenase is the key enzyme involved in betalain biosynthesis. It converts 3,4-dihydroxyphenylalanine to betalamic acid, a yellow chromophore.


:

Pssm-ID: 430285  Cd Length: 105  Bit Score: 108.76  E-value: 3.15e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715740932   2 YHGHIYF---PLRFAEQAETLRQKILSERkDVLETFPLIQRLVGPHKMPMFEIHFSNKESG-IVEWLEQERGDMSVLIHP 77
Cdd:pfam08883   1 YHAHIYFfqnDPAEVEYARALRERIRREF-PELRVGRFHDKPIGPHPVAMFEVNFTPEQFGaVVPWLALNRGPLSVLIHP 79

                          90       100
                  ....*....|....*....|....*..
gi 1715740932  78 VTgGEETLDHTVRATWLGRELGVFEDT 104
Cdd:pfam08883  80 NT-GDDLRDHTDRALWLGEPLPLDLSV 105
 
Name Accession Description Interval E-value
DOPA_dioxygen pfam08883
Dopa 4,5-dioxygenase family; This family of proteins are related to Swiss:P87064, a DOPA 4, ...
 2-104 3.15e-32

Dopa 4,5-dioxygenase family; This family of proteins are related to Swiss:P87064, a DOPA 4,5-dioxygenase that is involved in synthesis of betalain. DOPA-dioxygenase is the key enzyme involved in betalain biosynthesis. It converts 3,4-dihydroxyphenylalanine to betalamic acid, a yellow chromophore.


Pssm-ID: 430285  Cd Length: 105  Bit Score: 108.76  E-value: 3.15e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715740932   2 YHGHIYF---PLRFAEQAETLRQKILSERkDVLETFPLIQRLVGPHKMPMFEIHFSNKESG-IVEWLEQERGDMSVLIHP 77
Cdd:pfam08883   1 YHAHIYFfqnDPAEVEYARALRERIRREF-PELRVGRFHDKPIGPHPVAMFEVNFTPEQFGaVVPWLALNRGPLSVLIHP 79

                          90       100
                  ....*....|....*....|....*..
gi 1715740932  78 VTgGEETLDHTVRATWLGRELGVFEDT 104
Cdd:pfam08883  80 NT-GDDLRDHTDRALWLGEPLPLDLSV 105
DodA COG3805
Aromatic ring-cleaving dioxygenase [Secondary metabolites biosynthesis, transport and ...
 2-98 1.35e-23

Aromatic ring-cleaving dioxygenase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443018  Cd Length: 114  Bit Score: 86.87  E-value: 1.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715740932   2 YHGHIYFPLRFAEQAETLRQKIlSERkdvletFPL-----IQRLVGPHKMPMFEIHFSNKESG-IVEWLEQERGDMSVLI 75
Cdd:COG3805    12 YHAHVYFDEASREAAAALREEA-GER------FGVrvgrwHEKPVGPHPKWSYQLAFLPEQFDeVVPWLMLNRGGLDILV 84

                          90       100
                  ....*....|....*....|...
gi 1715740932  76 HPVTGgEETLDHTVRATWLGREL 98
Cdd:COG3805    85 HPLTG-DDLADHTDHALWLGESL 106
 
Name Accession Description Interval E-value
DOPA_dioxygen pfam08883
Dopa 4,5-dioxygenase family; This family of proteins are related to Swiss:P87064, a DOPA 4, ...
 2-104 3.15e-32

Dopa 4,5-dioxygenase family; This family of proteins are related to Swiss:P87064, a DOPA 4,5-dioxygenase that is involved in synthesis of betalain. DOPA-dioxygenase is the key enzyme involved in betalain biosynthesis. It converts 3,4-dihydroxyphenylalanine to betalamic acid, a yellow chromophore.


Pssm-ID: 430285  Cd Length: 105  Bit Score: 108.76  E-value: 3.15e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715740932   2 YHGHIYF---PLRFAEQAETLRQKILSERkDVLETFPLIQRLVGPHKMPMFEIHFSNKESG-IVEWLEQERGDMSVLIHP 77
Cdd:pfam08883   1 YHAHIYFfqnDPAEVEYARALRERIRREF-PELRVGRFHDKPIGPHPVAMFEVNFTPEQFGaVVPWLALNRGPLSVLIHP 79

                          90       100
                  ....*....|....*....|....*..
gi 1715740932  78 VTgGEETLDHTVRATWLGRELGVFEDT 104
Cdd:pfam08883  80 NT-GDDLRDHTDRALWLGEPLPLDLSV 105
DodA COG3805
Aromatic ring-cleaving dioxygenase [Secondary metabolites biosynthesis, transport and ...
 2-98 1.35e-23

Aromatic ring-cleaving dioxygenase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443018  Cd Length: 114  Bit Score: 86.87  E-value: 1.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1715740932   2 YHGHIYFPLRFAEQAETLRQKIlSERkdvletFPL-----IQRLVGPHKMPMFEIHFSNKESG-IVEWLEQERGDMSVLI 75
Cdd:COG3805    12 YHAHVYFDEASREAAAALREEA-GER------FGVrvgrwHEKPVGPHPKWSYQLAFLPEQFDeVVPWLMLNRGGLDILV 84

                          90       100
                  ....*....|....*....|...
gi 1715740932  76 HPVTGgEETLDHTVRATWLGREL 98
Cdd:COG3805    85 HPLTG-DDLADHTDHALWLGESL 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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