holin [Escherichia coli]
Protein Classification
phage holin family protein( domain architecture ID 581305)
phage holin family protein may function in the transport of murein hydrolases (endolysins) across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Phage_holin_3_3 super family | cl24062 | LydA holin phage, holin superfamily III; Phage_holin_3_3 is a family of small hydrophobic ... |
11-84 | 2.00e-03 | ||
LydA holin phage, holin superfamily III; Phage_holin_3_3 is a family of small hydrophobic holin proteins with one or more transmembrane domains. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as those of the bacteriophages of these organizms. Their primary function appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyse the cell wall polymer as a prelude to cell lysis. When chromosomally encoded, these enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases. LydA and lydB are encoded on the dar operon. The phenotype of a rapid lysis in the absence of active LydB suggests that this protein might be an antagonist of the holin LydA. The actual alignment was detected with superfamily member pfam16083: Pssm-ID: 451687 Cd Length: 78 Bit Score: 34.47 E-value: 2.00e-03
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| Name | Accession | Description | Interval | E-value | ||
| Phage_holin_3_3 | pfam16083 | LydA holin phage, holin superfamily III; Phage_holin_3_3 is a family of small hydrophobic ... |
11-84 | 2.00e-03 | ||
LydA holin phage, holin superfamily III; Phage_holin_3_3 is a family of small hydrophobic holin proteins with one or more transmembrane domains. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as those of the bacteriophages of these organizms. Their primary function appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyse the cell wall polymer as a prelude to cell lysis. When chromosomally encoded, these enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases. LydA and lydB are encoded on the dar operon. The phenotype of a rapid lysis in the absence of active LydB suggests that this protein might be an antagonist of the holin LydA. Pssm-ID: 435126 Cd Length: 78 Bit Score: 34.47 E-value: 2.00e-03
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| Name | Accession | Description | Interval | E-value | ||
| Phage_holin_3_3 | pfam16083 | LydA holin phage, holin superfamily III; Phage_holin_3_3 is a family of small hydrophobic ... |
11-84 | 2.00e-03 | ||
LydA holin phage, holin superfamily III; Phage_holin_3_3 is a family of small hydrophobic holin proteins with one or more transmembrane domains. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as those of the bacteriophages of these organizms. Their primary function appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyse the cell wall polymer as a prelude to cell lysis. When chromosomally encoded, these enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases. LydA and lydB are encoded on the dar operon. The phenotype of a rapid lysis in the absence of active LydB suggests that this protein might be an antagonist of the holin LydA. Pssm-ID: 435126 Cd Length: 78 Bit Score: 34.47 E-value: 2.00e-03
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