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Conserved domains on  [gi|1721271567|gb|TWY45116|]
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CusA/CzcA family heavy metal efflux RND transporter [Klebsiella pneumoniae]

Protein Classification

efflux RND transporter permease subunit( domain architecture ID 1004191)

efflux RND transporter permease subunit such as a CusA/CzcA family heavy metal efflux RND transporter, similar to Escherichia coli cation efflux system protein CusA, which mediates resistance to copper and silver

Gene Ontology:  GO:0008324|GO:0005886
TCDB:  2.A.6

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
ACR_tran super family cl47191
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
1-1049 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


The actual alignment was detected with superfamily member TIGR00914:

Pssm-ID: 481531 [Multi-domain]  Cd Length: 1051  Bit Score: 1602.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    1 MIEWIIRRSVANRFLVMMAALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGAR 80
Cdd:TIGR00914    1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSAEMGPDATGVGWVFEYALVDRSG-------KHDL 153
Cdd:TIGR00914   81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGarkkdggAYTL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  154 AELRSLQDWFLKYELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVELAEAEYMVRA 233
Cdd:TIGR00914  161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  234 SGYLQTLDDFKNIVLKTGDnGVPVYLGDVARVQIGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVISAVKEKLASLQS 313
Cdd:TIGR00914  241 PGQVQSMDDIRNIVIATGE-GVPIRIRDVARVQIGKELRTGAATENGK-EVVLGTVFMLIGENSRTVAQAVGDKLETINK 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  314 SLPEGVEVVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSL 393
Cdd:TIGR00914  319 TLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  394 GgiAIAVGAMVDAAIVMIENAHKRLEEWEHQHpGEKLSNDTRWKIITEASVEVGPALFISLLIITLSFIPIFTLEGQEGK 473
Cdd:TIGR00914  399 G--ALDFGLIVDGAVVIVENAHRRLAEAQHHH-GRQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGK 475
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  474 LFGPLAFTKTWSMAGAALLAIVAIPILMGFWIRGRIPaENSNPLNRFLIRIYHPLLLKVLHWPKTTLLIALLSILTVVWP 553
Cdd:TIGR00914  476 MFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVA-EKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWI 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  554 LNRVGGEFLPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMAVPEVARVFGKTGKAETATDSAPLEMVETTIQLKPQ 633
Cdd:TIGR00914  555 ASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIATDPMPPNASDTYIILKPE 634
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  634 DQWRPG--MTMEKIVDELDKTVRLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTNLADIDAIAGQIEGVARSVPGVT 711
Cdd:TIGR00914  635 SQWPEGkkTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAA 714
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  712 SALAERLVGGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRDSPETLRQLPILTP 791
Cdd:TIGR00914  715 DVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLP 794
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  792 L-----KQQIVLGDVAEVKVVTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQQAIGKEVKLKPGISVSYSGQFELLE 866
Cdd:TIGR00914  795 LsedarKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQ 874
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  867 RANQKLKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFIALAGVAAEFGVVMLM 946
Cdd:TIGR00914  875 SATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMIS 954
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  947 YLRHAIEAEPSlenpqtfsvdkLDEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLL 1026
Cdd:TIGR00914  955 FIRKLLEEGPS-----------LDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLL 1023
                         1050      1060
                   ....*....|....*....|...
gi 1721271567 1027 SLFIIPAAYKLMWLYRHRGKRSQ 1049
Cdd:TIGR00914 1024 TLFVLPALYRLVHRRRHKGRKEH 1046
 
Name Accession Description Interval E-value
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
1-1049 0e+00

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 1602.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    1 MIEWIIRRSVANRFLVMMAALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGAR 80
Cdd:TIGR00914    1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSAEMGPDATGVGWVFEYALVDRSG-------KHDL 153
Cdd:TIGR00914   81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGarkkdggAYTL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  154 AELRSLQDWFLKYELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVELAEAEYMVRA 233
Cdd:TIGR00914  161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  234 SGYLQTLDDFKNIVLKTGDnGVPVYLGDVARVQIGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVISAVKEKLASLQS 313
Cdd:TIGR00914  241 PGQVQSMDDIRNIVIATGE-GVPIRIRDVARVQIGKELRTGAATENGK-EVVLGTVFMLIGENSRTVAQAVGDKLETINK 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  314 SLPEGVEVVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSL 393
Cdd:TIGR00914  319 TLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  394 GgiAIAVGAMVDAAIVMIENAHKRLEEWEHQHpGEKLSNDTRWKIITEASVEVGPALFISLLIITLSFIPIFTLEGQEGK 473
Cdd:TIGR00914  399 G--ALDFGLIVDGAVVIVENAHRRLAEAQHHH-GRQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGK 475
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  474 LFGPLAFTKTWSMAGAALLAIVAIPILMGFWIRGRIPaENSNPLNRFLIRIYHPLLLKVLHWPKTTLLIALLSILTVVWP 553
Cdd:TIGR00914  476 MFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVA-EKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWI 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  554 LNRVGGEFLPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMAVPEVARVFGKTGKAETATDSAPLEMVETTIQLKPQ 633
Cdd:TIGR00914  555 ASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIATDPMPPNASDTYIILKPE 634
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  634 DQWRPG--MTMEKIVDELDKTVRLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTNLADIDAIAGQIEGVARSVPGVT 711
Cdd:TIGR00914  635 SQWPEGkkTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAA 714
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  712 SALAERLVGGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRDSPETLRQLPILTP 791
Cdd:TIGR00914  715 DVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLP 794
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  792 L-----KQQIVLGDVAEVKVVTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQQAIGKEVKLKPGISVSYSGQFELLE 866
Cdd:TIGR00914  795 LsedarKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQ 874
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  867 RANQKLKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFIALAGVAAEFGVVMLM 946
Cdd:TIGR00914  875 SATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMIS 954
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  947 YLRHAIEAEPSlenpqtfsvdkLDEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLL 1026
Cdd:TIGR00914  955 FIRKLLEEGPS-----------LDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLL 1023
                         1050      1060
                   ....*....|....*....|...
gi 1721271567 1027 SLFIIPAAYKLMWLYRHRGKRSQ 1049
Cdd:TIGR00914 1024 TLFVLPALYRLVHRRRHKGRKEH 1046
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
1-1049 0e+00

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 1494.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    1 MIEWIIRRSVANRFLVMMAALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGAR 80
Cdd:COG3696      1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSAEMGPDATGVGWVFEYALVDRSGKHDLAELRSLQ 160
Cdd:COG3696     81 EVRSISRFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGVTPELGPISTGLGEIYQYTLESDPGKYSLMELRTLQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  161 DWFLKYELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVELAEAEYMVRASGYLQTL 240
Cdd:COG3696    161 DWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  241 DDFKNIVLKTgDNGVPVYLGDVARVQIGPEMRRGIAELNGEGEVAGGVVILRSGKNAREVISAVKEKLASLQSSLPEGVE 320
Cdd:COG3696    241 EDIENIVVKT-RNGTPVLLRDVAEVRIGPAPRRGAATLNGEGEVVGGIVLMLKGENALEVIEAVKAKLAELKPSLPEGVK 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  321 VVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIAIAV 400
Cdd:COG3696    320 IVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDF 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  401 GAMVDAAIVMIENAHKRLEEWEHQHPGEklsndTRWKIITEASVEVGPALFISLLIITLSFIPIFTLEGQEGKLFGPLAF 480
Cdd:COG3696    400 GIIVDGAVVMVENILRRLEENRAAGTPR-----ERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMAL 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  481 TKTWSMAGAALLAIVAIPILMGFWIRGRIPaENSNPLNRFLIRIYHPLLLKVLHWPKTTLLIALLSILTVVWPLNRVGGE 560
Cdd:COG3696    475 TVIFALLGALLLSLTLVPVLASLLLRGKVP-EKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPRLGSE 553
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  561 FLPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMAVPEVARVFGKTGKAETATDSAPLEMVETTIQLKPQDQWRPGM 640
Cdd:COG3696    554 FLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATDPMGVNMSETFVILKPRSEWRSGR 633
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  641 TMEKIVDELDKTV-RLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTNLADIDAIAGQIEGVARSVPGVTSALAERLV 719
Cdd:COG3696    634 TKEELIAEMREALeQIPGVNFNFSQPIQMRVDELLSGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAADVQVERVT 713
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  720 GGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRDSPETLRQLPILTPLKQQIVLG 799
Cdd:COG3696    714 GLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLS 793
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  800 DVAEVKVVTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQQAIGKEVKLKPGISVSYSGQFELLERANQKLKLMVPMT 879
Cdd:COG3696    794 QVADIEVVEGPNQISRENGRRRIVVQANVRGRDLGSFVAEAQAKVAEQVKLPPGYYIEWGGQFENLQRATARLAIVVPLA 873
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  880 LMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHAIEAEPSLE 959
Cdd:COG3696    874 LLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEGLDLR 953
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  960 npqtfsvdkldEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAYKlmW 1039
Cdd:COG3696    954 -----------EAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITSTLLTLLVLPALYL--L 1020
                         1050
                   ....*....|
gi 1721271567 1040 LYRHRGKRSQ 1049
Cdd:COG3696   1021 FGRRRLRRAA 1030
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
1-1037 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 712.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    1 MIEWIIRRSVAnrflVMMAALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGAR 80
Cdd:pfam00873    1 MSKFFIRRPIF----TLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLK 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVS-AEMGPDATGVGWVFEYALVDRSGKHDLAELRSL 159
Cdd:pfam00873   77 YMSSQSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQrPGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDY 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  160 QDWFLKYELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVELAEAEYMVRASGYLQT 239
Cdd:pfam00873  157 ADTNIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQS 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  240 LDDFKNIVLKtGDNGVPVYLGDVARVQIGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVISAVKEKLASLQSSLPEGV 319
Cdd:pfam00873  237 AEDFEKIIVK-NQDGSPVRLRDVATVELGSELYRGFATFNGK-PAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGV 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  320 EVVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIAIA 399
Cdd:pfam00873  315 EIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLA 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  400 VGAMVDAAIVMIENAHKRLEEwEHQHPGEKlsndtrwkiITEASVEVGPALFISLLIITLSFIPIFTLEGQEGKLFGPLA 479
Cdd:pfam00873  395 IGLVVDDAIVVVENIERVLEE-NGLKPLEA---------AYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFA 464
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  480 FTKTWSMAGAALLAIVAIPILMGFWIRGRIPAEN------SNPLNRFLIRIYHPLLLKVLHWPKTTLLIALLSILTVVWP 553
Cdd:pfam00873  465 ITIVLAILLSVLVALTLTPALCATLLKPRREPKHggffrwFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWL 544
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  554 LNRVGGEFLPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMAVPEVARVFGKTGKAEtATDSAPLEMVETTIQLKPQ 633
Cdd:pfam00873  545 FVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAF-SGDNNGPNSGDAFISLKPW 623
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  634 DQWR-PGMTMEKIVDELDKTVR-LPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTNLADIDAIAGQIEGVARSVPGVT 711
Cdd:pfam00873  624 KERPgPEKSVQALIERLRKALKqIPGANVFLFQPIQLRGLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLS 703
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  712 SALAERLVGGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRDSPETLRQLPILTP 791
Cdd:pfam00873  704 DVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNP 783
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  792 LKQQIVLGDVAEVKVVTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQQAIGKEVKLKPGISVSYSGQFELLERANQK 871
Cdd:pfam00873  784 YGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNS 863
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  872 LKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHA 951
Cdd:pfam00873  864 LPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANEL 943
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  952 IEAEPSlenpqtfsvdKLDEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFII 1031
Cdd:pfam00873  944 REQEGK----------SLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVV 1013

                   ....*.
gi 1721271567 1032 PAAYKL 1037
Cdd:pfam00873 1014 PVFYVL 1019
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
4-1037 7.90e-115

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 378.98  E-value: 7.90e-115
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    4 WIIRRSVANRFLVMMAALFlsiwGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGARTVR 83
Cdd:NF033617     3 VFIKRPVATLLLSLLILLL----GLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMT 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   84 GFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAG-----VSAEMGPDATGVGWV-FEYALVDRSGKHDLAELR 157
Cdd:NF033617    79 SQSSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEapdppVYRKANSADTPIMYIgLTSEEMPRGQLTDYAERV 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  158 slqdwfLKYELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVELAEAEYMVRASGYL 237
Cdd:NF033617   159 ------LAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQL 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  238 QTLDDFKNIVLKTGDNGVPVYLGDVARVQIGPEMRRGIAELNGEGEVAGGVVILrSGKNAREVISAVKEKLASLQSSLPE 317
Cdd:NF033617   233 KTAEDYEDLVIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQ-PGANPIEVADEIRALLPELQETLPK 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  318 GVEVVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIA 397
Cdd:NF033617   312 NIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALV 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  398 IAVGAMVDAAIVMIENAHKRLEEWEhqHPGEKLSNDTRwkiiteasvEVGpalfISLLIITLS----FIPIFTLEGQEGK 473
Cdd:NF033617   392 LAIGLVVDDAIVVVENIHRHIEEGE--SPLEAALKGAR---------EIG----FTVIAMTLTlvavYLPILFMGGLTGR 456
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  474 LFGPLAFTktwsMAGAALL-AIVAIPI--LMGFWIRGRIPAEN--SNPLNRFLIRI---YHPLLLKVLHWPKTTLLIALL 545
Cdd:NF033617   457 LFREFAVT----LAGAVIIsGIVALTLtpMMCSRLLKANEKPGrfARAVDRFFDGLtarYGRGLKWVLKHRPLTLVVALA 532
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  546 SILTVVWPLNRVGGEFLPQINEGDLLympSTLPGISAAQAADMLQKTDKL---IMAVPEVARVFGKTGKAETATDSAPLE 622
Cdd:NF033617   533 TLALLPLLYVFIPKELAPSEDRGVIF---GMIQAPQSISLDYMSAKMRDVekiLSSDPEVQSLTSFNGVGGNPGDNTGFG 609
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  623 MvettIQLKPQDQWRpgMTMEKIVDELDKTV-RLPGLA-NLW-VPPIRnridmLSTGIKSPIGIKV-SGTNLADIDAIAG 698
Cdd:NF033617   610 I----INLKPWDERD--VSAQEIIDRLRPKLaKVPGMDlFLFpLQDLP-----GGAGSSLPQYQVTlTPSDYDSLFTWAE 678
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  699 QIEGVARSVPGVTSALAERLVGGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRD 778
Cdd:NF033617   679 KLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRL 758
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  779 SPETLRQLPILTPLKQQIVLGDVAEVKVVTGPSMLKTENARPTSWI-YIDARDRDMVSVVHDLQQAigKEVKLKPGISVS 857
Cdd:NF033617   759 NPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFNQFNSATLsFNLAPGVSLGEAIEALDQA--AKELLPSGISGS 836
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  858 YSGQFELLERANQKLKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFIALAGVA 937
Cdd:NF033617   837 FQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLV 916
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  938 AEFGVVMLMYlrhAIEAEpsLENPQTFsvdklDEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMI 1017
Cdd:NF033617   917 KKNGILMVEF---ANELQ--RHQGLSR-----REAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIV 986
                         1050      1060
                   ....*....|....*....|
gi 1721271567 1018 GGMITAPLLSLFIIPAAYKL 1037
Cdd:NF033617   987 GGLGVGTLFTLFVLPVVYLL 1006
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
6-1038 7.77e-61

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 225.87  E-value: 7.77e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    6 IRRSVanrfLVMMAALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGARTVRGF 85
Cdd:PRK09579     8 IRRPV----LASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSV 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   86 SQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAG----VSAEMGPDATGVGWVFEYalvdrSGKHDLAELRSLQD 161
Cdd:PRK09579    84 SRQNFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDaedpVLSKEAADASALMYISFY-----SEEMSNPQITDYLS 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  162 WFLKYELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVElaeAEYMV---RASGYLQ 238
Cdd:PRK09579   159 RVIQPKLATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVK---GEYVVtsiNASTELK 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  239 TLDDFKNIVLKT-GDNgvPVYLGDVARVQIGPEMRRGIAELNGEGEVAGGVVILRSGkNAREVISAVKEKLASLQSSLPE 317
Cdd:PRK09579   236 SAEAFAAIPVKTsGDS--RVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSA-NPLDVIKEVRAIMPELESQLPP 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  318 GVEVVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIA 397
Cdd:PRK09579   313 NLKVSIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMV 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  398 IAVGAMVDAAIVMIENAHKRLEEwehqhpgeklsNDTRWKIITEASVEVgpALFISLLIITLS--FIPIFTLEGQEGKLF 475
Cdd:PRK09579   393 LAIGLVVDDAIVVVENIHRHIEE-----------GKSPFDAALEGAREI--AMPVVSMTITLAavYAPIGFLTGLTGALF 459
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  476 GPLAFTktwsMAGAALLA-IVAI---PILMGFWIRgriPAENSNPLNRFLIRI-------YHPLLLKVLHWPKTTLLIAL 544
Cdd:PRK09579   460 KEFALT----LAGAVIISgIVALtlsPMMCALLLR---HEENPSGLAHRLDRLferlkqrYQRALHGTLNTRPVVLVFAV 532
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  545 LSILTVVWPLNRVGGEFLPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMAVPEVARVFGKTGkaetatdsapLEMV 624
Cdd:PRK09579   533 IVLALIPVLLKFTQSELAPEEDQGIIFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQING----------FNGV 602
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  625 ETTIQ---LKPQDQwRPGMTMEKIVDELDKTVRLPGLANLWVppirNRIDMLSTGIKSPIGIKVSGTNlaDIDAIAGQIE 701
Cdd:PRK09579   603 QSGIGgflLKPWNE-RERTQMELLPLVQAKLEEIPGLQIFGF----NLPSLPGTGEGLPFQFVINTAN--DYESLLQVAQ 675
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  702 GV-ARSVPGVTSAlaerlvggrYLDID-----------IQREKAARYGMTVGDVQLFVSSAIGGAMVGE-TVEGvERYPI 768
Cdd:PRK09579   676 RVkQRAQESGKFA---------FLDIDlafdkpevvvdIDRAKAAQMGVSMQDLGGTLATLLGEGEINRfTIDG-RSYKV 745
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  769 NIRYPQSYRDSPETLRQLPILTPLKQQIVLGDVAEVKVVTGPSMLKTENARPTSWIyidaRDRDMVSVVHDLQ--QAIGK 846
Cdd:PRK09579   746 IAQVERPYRDNPGWLNNYYVKNEQGQLLPLSTLITLSDRARPRQLNQFQQLNSAII----SGFPIVSMGEAIEtvQQIAR 821
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  847 EvKLKPGISVSYSGQFELLERANQKLKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVAT 926
Cdd:PRK09579   822 E-EAPEGFAFDYAGASRQYVQEGSALWVTFGLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYT 900
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  927 GTGFIALAGVAAEFGVVMlmylrhaIEAEPSLENPQTFSVdklDEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGS 1006
Cdd:PRK09579   901 QVGLVTLIGLISKHGILI-------VEFANQLRHEQGLSR---REAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGA 970
                         1050      1060      1070
                   ....*....|....*....|....*....|..
gi 1721271567 1007 EVMSRIAAPMIGGMITAPLLSLFIIPAAYKLM 1038
Cdd:PRK09579   971 VSRFDIGLVIATGMSIGTLFTLFVLPCIYTLL 1002
 
Name Accession Description Interval E-value
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
1-1049 0e+00

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 1602.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    1 MIEWIIRRSVANRFLVMMAALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGAR 80
Cdd:TIGR00914    1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSAEMGPDATGVGWVFEYALVDRSG-------KHDL 153
Cdd:TIGR00914   81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGarkkdggAYTL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  154 AELRSLQDWFLKYELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVELAEAEYMVRA 233
Cdd:TIGR00914  161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  234 SGYLQTLDDFKNIVLKTGDnGVPVYLGDVARVQIGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVISAVKEKLASLQS 313
Cdd:TIGR00914  241 PGQVQSMDDIRNIVIATGE-GVPIRIRDVARVQIGKELRTGAATENGK-EVVLGTVFMLIGENSRTVAQAVGDKLETINK 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  314 SLPEGVEVVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSL 393
Cdd:TIGR00914  319 TLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  394 GgiAIAVGAMVDAAIVMIENAHKRLEEWEHQHpGEKLSNDTRWKIITEASVEVGPALFISLLIITLSFIPIFTLEGQEGK 473
Cdd:TIGR00914  399 G--ALDFGLIVDGAVVIVENAHRRLAEAQHHH-GRQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGK 475
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  474 LFGPLAFTKTWSMAGAALLAIVAIPILMGFWIRGRIPaENSNPLNRFLIRIYHPLLLKVLHWPKTTLLIALLSILTVVWP 553
Cdd:TIGR00914  476 MFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVA-EKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWI 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  554 LNRVGGEFLPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMAVPEVARVFGKTGKAETATDSAPLEMVETTIQLKPQ 633
Cdd:TIGR00914  555 ASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIATDPMPPNASDTYIILKPE 634
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  634 DQWRPG--MTMEKIVDELDKTVRLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTNLADIDAIAGQIEGVARSVPGVT 711
Cdd:TIGR00914  635 SQWPEGkkTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAA 714
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  712 SALAERLVGGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRDSPETLRQLPILTP 791
Cdd:TIGR00914  715 DVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLP 794
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  792 L-----KQQIVLGDVAEVKVVTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQQAIGKEVKLKPGISVSYSGQFELLE 866
Cdd:TIGR00914  795 LsedarKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQ 874
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  867 RANQKLKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFIALAGVAAEFGVVMLM 946
Cdd:TIGR00914  875 SATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMIS 954
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  947 YLRHAIEAEPSlenpqtfsvdkLDEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLL 1026
Cdd:TIGR00914  955 FIRKLLEEGPS-----------LDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLL 1023
                         1050      1060
                   ....*....|....*....|...
gi 1721271567 1027 SLFIIPAAYKLMWLYRHRGKRSQ 1049
Cdd:TIGR00914 1024 TLFVLPALYRLVHRRRHKGRKEH 1046
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
1-1049 0e+00

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 1494.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    1 MIEWIIRRSVANRFLVMMAALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGAR 80
Cdd:COG3696      1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSAEMGPDATGVGWVFEYALVDRSGKHDLAELRSLQ 160
Cdd:COG3696     81 EVRSISRFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGVTPELGPISTGLGEIYQYTLESDPGKYSLMELRTLQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  161 DWFLKYELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVELAEAEYMVRASGYLQTL 240
Cdd:COG3696    161 DWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  241 DDFKNIVLKTgDNGVPVYLGDVARVQIGPEMRRGIAELNGEGEVAGGVVILRSGKNAREVISAVKEKLASLQSSLPEGVE 320
Cdd:COG3696    241 EDIENIVVKT-RNGTPVLLRDVAEVRIGPAPRRGAATLNGEGEVVGGIVLMLKGENALEVIEAVKAKLAELKPSLPEGVK 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  321 VVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIAIAV 400
Cdd:COG3696    320 IVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDF 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  401 GAMVDAAIVMIENAHKRLEEWEHQHPGEklsndTRWKIITEASVEVGPALFISLLIITLSFIPIFTLEGQEGKLFGPLAF 480
Cdd:COG3696    400 GIIVDGAVVMVENILRRLEENRAAGTPR-----ERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMAL 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  481 TKTWSMAGAALLAIVAIPILMGFWIRGRIPaENSNPLNRFLIRIYHPLLLKVLHWPKTTLLIALLSILTVVWPLNRVGGE 560
Cdd:COG3696    475 TVIFALLGALLLSLTLVPVLASLLLRGKVP-EKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPRLGSE 553
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  561 FLPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMAVPEVARVFGKTGKAETATDSAPLEMVETTIQLKPQDQWRPGM 640
Cdd:COG3696    554 FLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATDPMGVNMSETFVILKPRSEWRSGR 633
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  641 TMEKIVDELDKTV-RLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTNLADIDAIAGQIEGVARSVPGVTSALAERLV 719
Cdd:COG3696    634 TKEELIAEMREALeQIPGVNFNFSQPIQMRVDELLSGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAADVQVERVT 713
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  720 GGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRDSPETLRQLPILTPLKQQIVLG 799
Cdd:COG3696    714 GLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLS 793
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  800 DVAEVKVVTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQQAIGKEVKLKPGISVSYSGQFELLERANQKLKLMVPMT 879
Cdd:COG3696    794 QVADIEVVEGPNQISRENGRRRIVVQANVRGRDLGSFVAEAQAKVAEQVKLPPGYYIEWGGQFENLQRATARLAIVVPLA 873
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  880 LMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHAIEAEPSLE 959
Cdd:COG3696    874 LLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEGLDLR 953
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  960 npqtfsvdkldEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAYKlmW 1039
Cdd:COG3696    954 -----------EAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITSTLLTLLVLPALYL--L 1020
                         1050
                   ....*....|
gi 1721271567 1040 LYRHRGKRSQ 1049
Cdd:COG3696   1021 FGRRRLRRAA 1030
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
1-1037 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 712.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    1 MIEWIIRRSVAnrflVMMAALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGAR 80
Cdd:pfam00873    1 MSKFFIRRPIF----TLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLK 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVS-AEMGPDATGVGWVFEYALVDRSGKHDLAELRSL 159
Cdd:pfam00873   77 YMSSQSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQrPGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDY 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  160 QDWFLKYELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVELAEAEYMVRASGYLQT 239
Cdd:pfam00873  157 ADTNIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQS 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  240 LDDFKNIVLKtGDNGVPVYLGDVARVQIGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVISAVKEKLASLQSSLPEGV 319
Cdd:pfam00873  237 AEDFEKIIVK-NQDGSPVRLRDVATVELGSELYRGFATFNGK-PAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGV 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  320 EVVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIAIA 399
Cdd:pfam00873  315 EIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLA 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  400 VGAMVDAAIVMIENAHKRLEEwEHQHPGEKlsndtrwkiITEASVEVGPALFISLLIITLSFIPIFTLEGQEGKLFGPLA 479
Cdd:pfam00873  395 IGLVVDDAIVVVENIERVLEE-NGLKPLEA---------AYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFA 464
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  480 FTKTWSMAGAALLAIVAIPILMGFWIRGRIPAEN------SNPLNRFLIRIYHPLLLKVLHWPKTTLLIALLSILTVVWP 553
Cdd:pfam00873  465 ITIVLAILLSVLVALTLTPALCATLLKPRREPKHggffrwFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWL 544
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  554 LNRVGGEFLPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMAVPEVARVFGKTGKAEtATDSAPLEMVETTIQLKPQ 633
Cdd:pfam00873  545 FVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAF-SGDNNGPNSGDAFISLKPW 623
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  634 DQWR-PGMTMEKIVDELDKTVR-LPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTNLADIDAIAGQIEGVARSVPGVT 711
Cdd:pfam00873  624 KERPgPEKSVQALIERLRKALKqIPGANVFLFQPIQLRGLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLS 703
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  712 SALAERLVGGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRDSPETLRQLPILTP 791
Cdd:pfam00873  704 DVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNP 783
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  792 LKQQIVLGDVAEVKVVTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQQAIGKEVKLKPGISVSYSGQFELLERANQK 871
Cdd:pfam00873  784 YGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNS 863
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  872 LKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHA 951
Cdd:pfam00873  864 LPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANEL 943
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  952 IEAEPSlenpqtfsvdKLDEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFII 1031
Cdd:pfam00873  944 REQEGK----------SLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVV 1013

                   ....*.
gi 1721271567 1032 PAAYKL 1037
Cdd:pfam00873 1014 PVFYVL 1019
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1-1047 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 645.62  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    1 MIEWIIRRSVAnrflVMMAALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGAR 80
Cdd:COG0841      3 LSRFFIRRPVA----AIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVS----AEMGPDATGVGWVfeyALvdRSGKHDLAEL 156
Cdd:COG0841     79 YITSTSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEppgvTKVNPSDFPVMVL---AL--SSDDLDELEL 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  157 RSLQDWFLKYELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVELAEAEYMVRASGY 236
Cdd:COG0841    154 SDYAERNIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGR 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  237 LQTLDDFKNIVLKTgDNGVPVYLGDVARVQIGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVISAVKEKLASLQSSLP 316
Cdd:COG0841    234 LKTPEEFENIVIRT-NDGSVVRLGDVARVEDGAEDYRSIARLNGK-PAVGLAIQKQPGANALEVADAVRAKLEELQASLP 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  317 EGVEVVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGI 396
Cdd:COG0841    312 EGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFAL 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  397 AIAVGAMVDAAIVMIENAHKRLEEwehqhpGEklsndTRWKIITEASVEVGPALFISLLIITLSFIPIFTLEGQEGKLFG 476
Cdd:COG0841    392 VLAIGIVVDDAIVVVENIERHMEE------GL-----SPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFR 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  477 PLAFTKTWSMAGAALLAIVAIPILMGFWIRGRIPAENSNPLNRF------LIRIYHPLLLKVLHWPKTTLLIALLSILTV 550
Cdd:COG0841    461 QFALTVAIALLISLFVALTLTPALCARLLKPHPKGKKGRFFRAFnrgfdrLTRGYGRLLRWALRHRKLTLLVALALLALS 540
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  551 VWPLNRVGGEFLPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMAVPEVARVFGKTGKAETATDSApleMVETTIQL 630
Cdd:COG0841    541 VLLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSGSN---SGTIFVTL 617
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  631 KPQDQwRPgMTMEKIVDEL-DKTVRLPGL-ANLWVPPIRNRidmlstGIKSPIGIKVSGTNLADIDAIAGQIEGVARSVP 708
Cdd:COG0841    618 KPWDE-RD-RSADEIIARLrEKLAKIPGArVFVFQPPAGGL------GSGAPIEVQLQGDDLEELAAAAEKLLAALRQIP 689
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  709 GVTSALAERLVGGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRDSPETLRQLPI 788
Cdd:COG0841    690 GLVDVRSDLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYV 769
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  789 LTPLKQQIVLGDVAEVKVVTGPSMLKTENARPTSWIYID-ARDRDMVSVVHDLQQAIgKEVKLKPGISVSYSGQFELLER 867
Cdd:COG0841    770 RTPDGEMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANlAPGVSLGEALAAIEELA-AELKLPPGVSIEFTGQAEEEQE 848
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  868 ANQKLKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFIALAGVAAEFGVVMLMY 947
Cdd:COG0841    849 SFSSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDF 928
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  948 LRHAIEAEPSLEnpqtfsvdkldEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLS 1027
Cdd:COG0841    929 ANQLREEGMSLR-----------EAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLT 997
                         1050      1060
                   ....*....|....*....|
gi 1721271567 1028 LFIIPAAYklMWLYRHRGKR 1047
Cdd:COG0841    998 LFVVPVLY--VLLDRLRRRL 1015
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
4-1037 7.90e-115

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 378.98  E-value: 7.90e-115
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    4 WIIRRSVANRFLVMMAALFlsiwGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGARTVR 83
Cdd:NF033617     3 VFIKRPVATLLLSLLILLL----GLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMT 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   84 GFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAG-----VSAEMGPDATGVGWV-FEYALVDRSGKHDLAELR 157
Cdd:NF033617    79 SQSSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEapdppVYRKANSADTPIMYIgLTSEEMPRGQLTDYAERV 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  158 slqdwfLKYELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVELAEAEYMVRASGYL 237
Cdd:NF033617   159 ------LAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQL 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  238 QTLDDFKNIVLKTGDNGVPVYLGDVARVQIGPEMRRGIAELNGEGEVAGGVVILrSGKNAREVISAVKEKLASLQSSLPE 317
Cdd:NF033617   233 KTAEDYEDLVIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQ-PGANPIEVADEIRALLPELQETLPK 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  318 GVEVVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIA 397
Cdd:NF033617   312 NIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALV 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  398 IAVGAMVDAAIVMIENAHKRLEEWEhqHPGEKLSNDTRwkiiteasvEVGpalfISLLIITLS----FIPIFTLEGQEGK 473
Cdd:NF033617   392 LAIGLVVDDAIVVVENIHRHIEEGE--SPLEAALKGAR---------EIG----FTVIAMTLTlvavYLPILFMGGLTGR 456
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  474 LFGPLAFTktwsMAGAALL-AIVAIPI--LMGFWIRGRIPAEN--SNPLNRFLIRI---YHPLLLKVLHWPKTTLLIALL 545
Cdd:NF033617   457 LFREFAVT----LAGAVIIsGIVALTLtpMMCSRLLKANEKPGrfARAVDRFFDGLtarYGRGLKWVLKHRPLTLVVALA 532
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  546 SILTVVWPLNRVGGEFLPQINEGDLLympSTLPGISAAQAADMLQKTDKL---IMAVPEVARVFGKTGKAETATDSAPLE 622
Cdd:NF033617   533 TLALLPLLYVFIPKELAPSEDRGVIF---GMIQAPQSISLDYMSAKMRDVekiLSSDPEVQSLTSFNGVGGNPGDNTGFG 609
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  623 MvettIQLKPQDQWRpgMTMEKIVDELDKTV-RLPGLA-NLW-VPPIRnridmLSTGIKSPIGIKV-SGTNLADIDAIAG 698
Cdd:NF033617   610 I----INLKPWDERD--VSAQEIIDRLRPKLaKVPGMDlFLFpLQDLP-----GGAGSSLPQYQVTlTPSDYDSLFTWAE 678
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  699 QIEGVARSVPGVTSALAERLVGGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRD 778
Cdd:NF033617   679 KLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRL 758
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  779 SPETLRQLPILTPLKQQIVLGDVAEVKVVTGPSMLKTENARPTSWI-YIDARDRDMVSVVHDLQQAigKEVKLKPGISVS 857
Cdd:NF033617   759 NPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFNQFNSATLsFNLAPGVSLGEAIEALDQA--AKELLPSGISGS 836
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  858 YSGQFELLERANQKLKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFIALAGVA 937
Cdd:NF033617   837 FQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLV 916
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  938 AEFGVVMLMYlrhAIEAEpsLENPQTFsvdklDEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMI 1017
Cdd:NF033617   917 KKNGILMVEF---ANELQ--RHQGLSR-----REAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIV 986
                         1050      1060
                   ....*....|....*....|
gi 1721271567 1018 GGMITAPLLSLFIIPAAYKL 1037
Cdd:NF033617   987 GGLGVGTLFTLFVLPVVYLL 1006
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
20-1035 4.38e-83

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 291.63  E-value: 4.38e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   20 ALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGARTVRGFSQF-GDSYVYVIFE 98
Cdd:TIGR00915   16 AIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSSSDSdGSMTITLTFE 95
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   99 DGTDPYWARSRVLEYLNQVQGKLPA-----GVSAEmgpdATGVGWVFEYALVDRSGKHDLAELRSLQDWFLKYELKTIPN 173
Cdd:TIGR00915   96 QGTDPDIAQVQVQNKLQLATPLLPQevqrqGVRVE----KASSNFLMVIGLVSDDGSMTKEDLSDYAASNMVDPLSRLEG 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  174 VSEVaSVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASN-QEAGGS-----SVELAEAEYMVRASGYLQTLDDFKNIV 247
Cdd:TIGR00915  172 VGDV-QLFGSQYAMRIWLDPAKLNSYQLTPADVISAISAQNaQISAGQlgglpAVPGQQLNATIIAQTRLQTPEQFENIL 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  248 LKTGDNGVPVYLGDVARVQIGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVISAVKEKLASLQSSLPEGVEVVTTYDR 327
Cdd:TIGR00915  251 LKVNTDGSQVRLKDVARVELGGENYSISARFNGK-PASGLAIKLATGANALDTAKAVKAELAVLEPFFPQGMKYVYPYDT 329
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  328 SQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIAIAVGAMVDAA 407
Cdd:TIGR00915  330 TPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVLAIGLLVDDA 409
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  408 IVMIENAHKRLEEwEHQHPGEKLSNdtRWKIITEASVEVGpalfislLIITLSFIPIFTLEGQEGKLFGPLAFTKTWSMA 487
Cdd:TIGR00915  410 IVVVENVERVMAE-EGLPPKEATRK--SMGQIQGALVGIA-------MVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMA 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  488 GAALLAIVAIPILMGFWIRGRIPAENS-------NPLNRFLIRI---YHPLLLKVLHWPKTTLLIALLSILTVVWPLNRV 557
Cdd:TIGR00915  480 LSVLVALILTPALCATMLKPIEKGEHHekkggffGWFNRMFDSSthgYENGVGKILRRRGRYLLVYVLLVGGMVFLFVRL 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  558 GGEFLPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMAVP--EVARVFGKTGkAETATDSAPLEMVetTIQLKP-QD 634
Cdd:TIGR00915  560 PTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEkaNVESVFTVNG-FSFAGRGQNMGMA--FIRLKDwEE 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  635 QWRPGMTMEKIVDELDK---TVRLPGLANLWVPPIRnridmlstGIKSPIGIKV-----SGTNLADIDAIAGQIEGVARS 706
Cdd:TIGR00915  637 RTGKENSVFAIAGRATGhfmQIKDAMVIAFVPPAIL--------ELGNATGFDFflqdrAGLGHEALLQARNQLLGLAAQ 708
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  707 VPGVTSALAERLVGGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRDSPETLRQL 786
Cdd:TIGR00915  709 NPALTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKW 788
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  787 PILTPLKQQIVLGDVAEVKVVTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQQAIGKevKLKPGISVSYSGQ-FELL 865
Cdd:TIGR00915  789 YVRNASGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQ--KLPPGFGFSWTGMsYEER 866
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  866 ERANQKLkLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFIALAGVAAEFGVVML 945
Cdd:TIGR00915  867 LSGSQAP-ALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIV 945
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  946 MYLRHAIEAEPSLEnpqtfsvdkldEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPL 1025
Cdd:TIGR00915  946 EFAKELMAQGKSIV-----------EAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATV 1014
                         1050
                   ....*....|
gi 1721271567 1026 LSLFIIPAAY 1035
Cdd:TIGR00915 1015 LAIFFVPLFY 1024
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
6-1038 7.77e-61

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 225.87  E-value: 7.77e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    6 IRRSVanrfLVMMAALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGARTVRGF 85
Cdd:PRK09579     8 IRRPV----LASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSV 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   86 SQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAG----VSAEMGPDATGVGWVFEYalvdrSGKHDLAELRSLQD 161
Cdd:PRK09579    84 SRQNFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDaedpVLSKEAADASALMYISFY-----SEEMSNPQITDYLS 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  162 WFLKYELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVElaeAEYMV---RASGYLQ 238
Cdd:PRK09579   159 RVIQPKLATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVK---GEYVVtsiNASTELK 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  239 TLDDFKNIVLKT-GDNgvPVYLGDVARVQIGPEMRRGIAELNGEGEVAGGVVILRSGkNAREVISAVKEKLASLQSSLPE 317
Cdd:PRK09579   236 SAEAFAAIPVKTsGDS--RVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSA-NPLDVIKEVRAIMPELESQLPP 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  318 GVEVVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIA 397
Cdd:PRK09579   313 NLKVSIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMV 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  398 IAVGAMVDAAIVMIENAHKRLEEwehqhpgeklsNDTRWKIITEASVEVgpALFISLLIITLS--FIPIFTLEGQEGKLF 475
Cdd:PRK09579   393 LAIGLVVDDAIVVVENIHRHIEE-----------GKSPFDAALEGAREI--AMPVVSMTITLAavYAPIGFLTGLTGALF 459
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  476 GPLAFTktwsMAGAALLA-IVAI---PILMGFWIRgriPAENSNPLNRFLIRI-------YHPLLLKVLHWPKTTLLIAL 544
Cdd:PRK09579   460 KEFALT----LAGAVIISgIVALtlsPMMCALLLR---HEENPSGLAHRLDRLferlkqrYQRALHGTLNTRPVVLVFAV 532
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  545 LSILTVVWPLNRVGGEFLPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMAVPEVARVFGKTGkaetatdsapLEMV 624
Cdd:PRK09579   533 IVLALIPVLLKFTQSELAPEEDQGIIFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQING----------FNGV 602
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  625 ETTIQ---LKPQDQwRPGMTMEKIVDELDKTVRLPGLANLWVppirNRIDMLSTGIKSPIGIKVSGTNlaDIDAIAGQIE 701
Cdd:PRK09579   603 QSGIGgflLKPWNE-RERTQMELLPLVQAKLEEIPGLQIFGF----NLPSLPGTGEGLPFQFVINTAN--DYESLLQVAQ 675
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  702 GV-ARSVPGVTSAlaerlvggrYLDID-----------IQREKAARYGMTVGDVQLFVSSAIGGAMVGE-TVEGvERYPI 768
Cdd:PRK09579   676 RVkQRAQESGKFA---------FLDIDlafdkpevvvdIDRAKAAQMGVSMQDLGGTLATLLGEGEINRfTIDG-RSYKV 745
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  769 NIRYPQSYRDSPETLRQLPILTPLKQQIVLGDVAEVKVVTGPSMLKTENARPTSWIyidaRDRDMVSVVHDLQ--QAIGK 846
Cdd:PRK09579   746 IAQVERPYRDNPGWLNNYYVKNEQGQLLPLSTLITLSDRARPRQLNQFQQLNSAII----SGFPIVSMGEAIEtvQQIAR 821
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  847 EvKLKPGISVSYSGQFELLERANQKLKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVAT 926
Cdd:PRK09579   822 E-EAPEGFAFDYAGASRQYVQEGSALWVTFGLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYT 900
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  927 GTGFIALAGVAAEFGVVMlmylrhaIEAEPSLENPQTFSVdklDEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGS 1006
Cdd:PRK09579   901 QVGLVTLIGLISKHGILI-------VEFANQLRHEQGLSR---REAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGA 970
                         1050      1060      1070
                   ....*....|....*....|....*....|..
gi 1721271567 1007 EVMSRIAAPMIGGMITAPLLSLFIIPAAYKLM 1038
Cdd:PRK09579   971 VSRFDIGLVIATGMSIGTLFTLFVLPCIYTLL 1002
PRK09577 PRK09577
multidrug efflux RND transporter permease subunit;
20-1048 8.90e-60

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169981 [Multi-domain]  Cd Length: 1032  Bit Score: 222.81  E-value: 8.90e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   20 ALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGARTVRGFSQFGDSYVYVIFED 99
Cdd:PRK09577    16 SLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSSAGQASLSLTFKQ 95
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  100 GTDPYWARSRVLEYLNQVQGKLP-----AGVSAEMGPDATGVgwvfEYALVDRSGKHDLAELRSLQDWFLKYELKTIPNV 174
Cdd:PRK09577    96 GVNADLAAVEVQNRLKTVEARLPepvrrDGIQVEKAADNIQL----IVSLTSDDGRLTGVELGEYASANVLQALRRVEGV 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  175 SEVASVGGvvkEY--QIVVDPMKLTQYGISLGEVKSALDASNQ-----EAGGSSV-ELAEAEYMVRASGYLQTLDDFKNI 246
Cdd:PRK09577   172 GKVQFWGA---EYamRIWPDPVKLAALGLTASDIASAVRAHNArvtigDIGRSAVpDSAPIAATVFADAPLKTPEDFGAI 248
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  247 VLKTGDNGVPVYLGDVARVQIGPEMRRGIAELNGEgeVAGGVVI-LRSGKNAREVISAVKEKLASLQSSLPEGVEVVTTY 325
Cdd:PRK09577   249 ALRARADGSALYLRDVARIEFGGNDYNYPSYVNGK--TATGMGIkLAPGSNAVATEKRVRATMDELSRYFPPGVKYQIPY 326
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  326 DRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIAIAVGAMVD 405
Cdd:PRK09577   327 ETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVLAIGILVD 406
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  406 AAIVMIENAHKRLEEwehqhpgEKLS-NDTRWKIITEASvevGPALFISLLIITLsFIPIFTLEGQEGKLFGPLAFTKTW 484
Cdd:PRK09577   407 DAIVVVENVERLMVE-------EGLSpYDATVKAMKQIS---GAIVGITVVLTSV-FVPMAFFGGAVGNIYRQFALSLAV 475
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  485 SMAGAALLAIVAIPILMGFWIRgRIPAENSNP------LNRFLIRI---YHPLLLKVLHWPKTTLLIALLSILTVVWPLN 555
Cdd:PRK09577   476 SIGFSAFLALSLTPALCATLLK-PVDGDHHEKrgffgwFNRFVARStqrYATRVGAILKRPLRWLVVYGALTAAAALLFT 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  556 RVGGEFLPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMAVPEVARVFGKTGKA--ETATDSApleMVETTIQlKPQ 633
Cdd:PRK09577   555 RLPTAFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNlyGEGPNGG---MIFVTLK-DWK 630
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  634 DQWRPGMTMEKIVDELDKtvRLPGLANLWV-----PPIRnriDMLSTGikspiGIKVSGTNLADID-----AIAGQIEGV 703
Cdd:PRK09577   631 ERKAARDHVQAIVARINE--RFAGTPNTTVfamnsPALP---DLGSTS-----GFDFRLQDRGGLGyaafvAAREQLLAE 700
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  704 ARSVPGVTSALAERLVGGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRDSPETL 783
Cdd:PRK09577   701 GAKDPALTDLMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDV 780
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  784 RQLPILTPLKQQIVLGDVAEVKVVTGPSMLKTENARPTswIYIDARDRDMVSVVHDLQQAIGKEVKLKPGISVSYSGQFE 863
Cdd:PRK09577   781 KKLRVRNAQGEMVPLAAFATLHWTLGPPQLTRYNGYPS--FTINGSAAPGHSSGEAMAAIERIAATLPAGIGYAWSGQSF 858
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  864 LLERANQKLKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFIALAGVAAEFGVV 943
Cdd:PRK09577   859 EERLSGAQAPMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAIL 938
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  944 MLMYLRHAIEAEPSLenpqtfsvdkLDEALyQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITA 1023
Cdd:PRK09577   939 IVEVAKDLVAQRMSL----------ADAAL-EAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVITA 1007
                         1050      1060
                   ....*....|....*....|....*
gi 1721271567 1024 PLLSLFIIPAAYKLMWLYRHRGKRS 1048
Cdd:PRK09577  1008 TVLAVFLVPLFFVVVGRLFDVGPRR 1032
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
20-1032 1.59e-57

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 216.31  E-value: 1.59e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   20 ALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGARTVRGFS-QFGDSYVYVIFE 98
Cdd:PRK15127    16 AIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdSTGTVQITLTFE 95
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   99 DGTDPYWARSRVLEYLNQVQGKLPAGVSAE-MGPDATGVGWVFEYALVDRSGKHDLAELRSLQDWFLKYELKTIPNVSEV 177
Cdd:PRK15127    96 SGTDADIAQVQVQNKLQLAMPLLPQEVQQQgVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDPISRTSGVGDV 175
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  178 aSVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASN------QEAGGSSVELAEAEYMVRASGYLQTLDDFKNIVLKTG 251
Cdd:PRK15127   176 -QLFGSQYAMRIWMNPNELNKFQLTPVDVINAIKAQNaqvaagQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVN 254
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  252 DNGVPVYLGDVARVQIGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVISAVKEKLASLQSSLPEGVEVVTTYDRSQLI 331
Cdd:PRK15127   255 QDGSRVRLRDVAKIELGGENYDIIAEFNGQ-PASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFV 333
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  332 DRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIAIAVGAMVDAAIVMI 411
Cdd:PRK15127   334 KISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVV 413
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  412 ENAHKRLEEwEHQHPGEKlsndTRWKIITEASVEVGPALFISLLiitlsFIPIFTLEGQEGKLFGPLAFTKTWSMAGAAL 491
Cdd:PRK15127   414 ENVERVMAE-EGLPPKEA----TRKSMGQIQGALVGIAMVLSAV-----FVPMAFFGGSTGAIYRQFSITIVSAMALSVL 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  492 LAIVAIPILMGFWIRGRIPAENSNP-------LNRFLIRIYHPLLLKVLHWPKTT---LLIALLSILTVVWPLNRVGGEF 561
Cdd:PRK15127   484 VALILTPALCATMLKPIAKGDHGEGkkgffgwFNRMFEKSTHHYTDSVGNILRSTgryLVLYLIIVVGMAYLFVRLPSSF 563
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  562 LPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMA-----VPEVARV--FGKTGKAETATDSaplemvetTIQLKPQD 634
Cdd:PRK15127   564 LPDEDQGVFLTMVQLPAGATQERTQKVLNEVTDYYLTkeknnVESVFAVngFGFAGRGQNTGIA--------FVSLKDWA 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  635 QwRPGMTME-------------KIVDELDKTVRLPGLANLWVppirnridmlSTGIKSPIgIKVSGTNLADIDAIAGQIE 701
Cdd:PRK15127   636 D-RPGEENKveaitmratrafsQIKDAMVFAFNLPAIVELGT----------ATGFDFEL-IDQAGLGHEKLTQARNQLL 703
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  702 GVARSVPGVtsalaerLVGGR--------YLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYP 773
Cdd:PRK15127   704 GEAAKHPDM-------LVGVRpngledtpQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSE 776
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  774 QSYRDSPETLRQLPILTPLKQQIVLGDVAEVKVVTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQQAIGKevKLKPG 853
Cdd:PRK15127   777 AKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEELAS--KLPTG 854
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  854 ISVSYSGqFELLER--ANQKLKLMVpMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFI 931
Cdd:PRK15127   855 VGYDWTG-MSYQERlsGNQAPALYA-ISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLL 932
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  932 ALAGVAAEFGVVMLMYLRHAIEAEPSlenpqtfsvdKLDEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSR 1011
Cdd:PRK15127   933 TTIGLSAKNAILIVEFAKDLMDKEGK----------GLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNA 1002
                         1050      1060
                   ....*....|....*....|.
gi 1721271567 1012 IAAPMIGGMITAPLLSLFIIP 1032
Cdd:PRK15127  1003 VGTGVMGGMVTATVLAIFFVP 1023
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
20-1032 1.60e-54

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 206.60  E-value: 1.60e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   20 ALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGARTVRG-FSQFGDSYVYVIFE 98
Cdd:PRK10555    16 AILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSqSSGTGQASVTLSFK 95
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   99 DGTDPYWARSRVLEYLNQVQGKLPAGVSAE-MGPDATGVGWVFEYALVDRSG---KHDLAEL--RSLQDwflkyELKTIP 172
Cdd:PRK10555    96 AGTDPDEAVQQVQNQLQSAMRKLPQAVQNQgVTVRKTGDTNILTIAFVSTDGsmdKQDIADYvaSNIQD-----PLSRVN 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  173 NVSEVASVGgvvKEY--QIVVDPMKLTQYGISLGEVKSALDASN------QEAGGSSVELAEAEYMVRASGYLQTLDDFK 244
Cdd:PRK10555   171 GVGDIDAYG---SQYsmRIWLDPAKLNSFQMTTKDVTDAIESQNaqiavgQLGGTPSVDKQALNATINAQSLLQTPEQFR 247
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  245 NIVLKTGDNGVPVYLGDVARVQIGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVISAVKEKLASLQSSLPEGVEVVTT 324
Cdd:PRK10555   248 DITLRVNQDGSEVTLGDVATVELGAEKYDYLSRFNGK-PASGLGVKLASGANEMATAKLVLNRLDELAQYFPHGLEYKVA 326
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  325 YDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIAIAVGAMV 404
Cdd:PRK10555   327 YETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVLAIGLLV 406
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  405 DAAIVMIENAHKRLEEwEHQHPGEKlsndTRWKIITEASVEVGPALFISLLiitlsFIPIFTLEGQEGKLFGPLAFTKTW 484
Cdd:PRK10555   407 DDAIVVVENVERIMSE-EGLTPREA----TRKSMGQIQGALVGIAMVLSAV-----FVPMAFFGGTTGAIYRQFSITIVS 476
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  485 SMAGAALLAIVAIPILMGFWIRGRIPAEN----------SNPLNRFLIRiYHPLLLKVLHWPKTTLLIALLSILTVVWPL 554
Cdd:PRK10555   477 AMVLSVLVAMILTPALCATLLKPLKKGEHhgqkgffgwfNRMFNRNAER-YEKGVAKILHRSLRWILIYVLLLGGMVFLF 555
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  555 NRVGGEFLPQINEGDLLYMPSTLPGISAAQAADMLQKTDK--LIMAVPEVARVFGKTGKAETATDSAPLEMVettIQLKP 632
Cdd:PRK10555   556 LRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKyyFTHEKDNVMSVFATVGSGPGGNGQNVARMF---IRLKD 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  633 QDQwRPGMTMEK--IVDELDKTVRLPGLANLWV--PPIrnridmlSTGIKSPIGIKVSGTNLADI--DAIAG---QIEGV 703
Cdd:PRK10555   633 WDE-RDSKTGTSfaIIERATKAFNKIKEARVIAssPPA-------ISGLGSSAGFDMELQDHAGAghDALMAarnQLLAL 704
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  704 ARSVPGVTSALAERLVGGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRDSPETL 783
Cdd:PRK10555   705 AAKNPELTRVRHNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDI 784
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  784 RQLPILTPLKQQIVLGDVAEVKVVTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQQAIGKevKLKPGISVSYSGQfE 863
Cdd:PRK10555   785 NLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVK--QLPNGFGLEWTAM-S 861
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  864 LLER-ANQKLKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVATGTGFIALAGVAAEFGV 942
Cdd:PRK10555   862 YQERlSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAI 941
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  943 VMLMYlrhaieaepslENPQTFSVDKLDEALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMIT 1022
Cdd:PRK10555   942 LIVEF-----------ANEMNQKGHDLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMIS 1010
                         1050
                   ....*....|
gi 1721271567 1023 APLLSLFIIP 1032
Cdd:PRK10555  1011 ATILAIFFVP 1020
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
6-1049 1.85e-49

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 190.71  E-value: 1.85e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    6 IRRSVANRFLvmmaALFLSIWGTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQIVENQVTWPLTTTMLSVPGARTVRGF 85
Cdd:PRK10614     8 IYRPVATILL----SLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSS 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   86 SQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSA-----EMGP-DATGVgwvfeyALVDRSGKHDLAELRSL 159
Cdd:PRK10614    84 SSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSrptyrKANPsDAPIM------ILTLTSDTYSQGQLYDF 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  160 QDWFLKYELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVELAEAEYMVRASGYLQT 239
Cdd:PRK10614   158 ASTQLAQTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKT 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  240 LDDFKNIVLKTgDNGVPVYLGDVARVQIGPEMRRGIAELNGEGEVAggVVILRS-GKNAREVISAVKEKLASLQSSLPEG 318
Cdd:PRK10614   238 AAEYQPLIIHY-NNGAAVRLGDVATVTDSVQDVRNAGMTNAKPAIL--LMIRKLpEANIIQTVDRIRAKLPELRETIPAA 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  319 VEVVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIAI 398
Cdd:PRK10614   315 IDLQIAQDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTI 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  399 AVGAMVDAAIVMIENAHKRLEewEHQHPGEKLSNDTRwkiiteasvEVG-PALFISLLIITLsFIPIFTLEGQEGKLFGP 477
Cdd:PRK10614   395 ATGFVVDDAIVVLENISRHLE--AGMKPLQAALQGVR---------EVGfTVLSMSLSLVAV-FLPLLLMGGLPGRLFRE 462
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  478 LAFTKTWSMAGAALLAIVAIPILMGFWIRGRIPAENSNP--LNRFLIRI---YHPLLLKVLHWPKTTLLIALLSILTVVW 552
Cdd:PRK10614   463 FAVTLSVAIGISLLVSLTLTPMMCAWLLKSSKPREQKRLrgFGRMLVALqqgYGRSLKWVLNHTRWVGVVLLGTIALNVW 542
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  553 PLNRVGGEFLPQINEGDLLYMPSTLPGISAAQAADMLQKTDKLIMAVPEVARVFGKTGKAETATDSaplemveTTIQLKP 632
Cdd:PRK10614   543 LYISIPKTFFPEQDTGRLMGFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGM-------MFITLKP 615
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  633 QDQwrPGMTMEKIVDEL-DKTVRLPGlANLWVPPIRnriDMLSTGIKSPIGIKVS--GTNLADIDAIAGQIEGVARSVPG 709
Cdd:PRK10614   616 LSE--RSETAQQVIDRLrVKLAKEPG-ANLFLMAVQ---DIRVGGRQSNASYQYTllSDDLAALREWEPKIRKALAALPE 689
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  710 VTSALAERLVGGRYLDIDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEGVERYPINIRYPQSYRDSPETLRQLPIL 789
Cdd:PRK10614   690 LADVNSDQQDKGAEMALTYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDISALEKMFVI 769
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  790 TPLKQQIVLGDVAEVKVVTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQQAIGKEVKLKPGISVSYSGQFELLERAN 869
Cdd:PRK10614   770 NNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIERAMTQLGVPSTVRGSFAGTAQVFQETM 849
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  870 QKLKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGGIWFLYWMGFHLSVatgtgfIALAGVAAEFGVV---MLM 946
Cdd:PRK10614   850 NSQLILILAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSL------IALIGIMLLIGIVkknAIM 923
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  947 YLRHAIEAEPSlenpqtfsvDKLD--EALYQGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAP 1024
Cdd:PRK10614   924 MVDFALEAQRN---------GNLTaqEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQ 994
                         1050      1060
                   ....*....|....*....|....*....
gi 1721271567 1025 LLSLFIIPAAY----KLMWLYRHRGKRSQ 1049
Cdd:PRK10614   995 LLTLYTTPVVYlffdRLRLRFSRKPKQTV 1023
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
6-1049 2.59e-43

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 171.45  E-value: 2.59e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    6 IRRSVANRfLVMMAALFLSIWGTWTIihtPVDALP--DLSDVQVIvkTRYPGQAPQIVENQVTWPLTTTMLSVPGARTVR 83
Cdd:PRK10503    17 ILRPVATT-LLMVAILLAGIIGYRAL---PVSALPevDYPTIQVV--TLYPGASPDVMTSAVTAPLERQFGQMSGLKQMS 90
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   84 GFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAG-----VSAEMGP-DATGVGWVFEYALVDRSGKHDLAELR 157
Cdd:PRK10503    91 SQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDlpnppVYSKVNPaDPPIMTLAVTSTAMPMTQVEDMVETR 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  158 SLQdwflkyELKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISLGEVKSALDASNQEAGGSSVELAEAEYMVRASGYL 237
Cdd:PRK10503   171 VAQ------KISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQM 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  238 QTLDDFKNIVLkTGDNGVPVYLGDVARVQIGPEMRRGIAELNGEGEVAGGVViLRSGKNAREVISAVKEKLASLQSSLPE 317
Cdd:PRK10503   245 QSAEEYRQLII-AYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQ-RQPGANIIATADSIRQMLPQLTESLPK 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  318 GVEVVTTYDRSQLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIA 397
Cdd:PRK10503   323 SVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALT 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  398 IAVGAMVDAAIVMIENAHKRLEEWEhqhpgeklsndtrwKIITEASVEVGPalfISLLIITLSF------IPIFTLEGQE 471
Cdd:PRK10503   403 IATGFVVDDAIVVIENISRYIEKGE--------------KPLAAALKGAGE---IGFTIISLTFsliavlIPLLFMGDIV 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  472 GKLFGPLAFTktwsMAGAALLAIVAIPILMGFWIRGRIPAENSNPLNRF----------LIRIYHPLLLKVLHWPKTTLL 541
Cdd:PRK10503   466 GRLFREFAVT----LAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFsrasermfdrVIAAYGRGLAKVLNHPWLTLS 541
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  542 IAL--LSILTVVWPLNRVGgeFLPQINEGDL---LYMPSTlpgISAAQAADMLQKTDKLIMAVPEVARV--FGKTGKAET 614
Cdd:PRK10503   542 VALstLLLTVLLWIFIPKG--FFPVQDNGIIqgtLQAPQS---SSFANMAQRQRQVADVILQDPAVQSLtsFVGVDGTNP 616
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  615 ATDSAPLEmvettIQLKPQDQWRPgmTMEKIVDELDKTV-RLPGlANLWVPPIRN-RIDMLSTGIKSPIGIKvsgtnlad 692
Cdd:PRK10503   617 SLNSARLQ-----INLKPLDERDD--RVQKVIARLQTAVaKVPG-VDLYLQPTQDlTIDTQVSRTQYQFTLQ-------- 680
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  693 idaiAGQIEGVARSVPGVTSALAERL----VGGRYLD------IDIQREKAARYGMTVGDVQLFVSSAIGGAMVGETVEG 762
Cdd:PRK10503   681 ----ATSLDALSTWVPKLMEKLQQLPqlsdVSSDWQDkglvayVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQ 756
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  763 VERYPINIRYPQSYRDSPETLRQLPILTPLKQQIVLGDVAEVKVVTGPSMLKTENARPTSWIYIDARD----RDMVSVVH 838
Cdd:PRK10503   757 ANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQRFGPLSINHLDQFPSTTISFNVPDgyslGDAVQAIM 836
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  839 DLQQAIGkevkLKPGISVSYSGQFELLERA-NQKLKLMVPMTLMIIFVL--LYLAFRrvgEALLIITSVPFALVGGIWFL 915
Cdd:PRK10503   837 DTEKTLN----LPADITTQFQGSTLAFQSAlGSTVWLIVAAVVAMYIVLgvLYESFI---HPITILSTLPTAGVGALLAL 909
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  916 YWMGFHLSVATGTGFIALAGVAAEFGVVMLMYlrhAIEAepslENPQTFSVdklDEALYQGAVLRVRPKAMTVAVIIAGL 995
Cdd:PRK10503   910 MIAGSELDVIAIIGIILLIGIVKKNAIMMIDF---ALAA----EREQGMSP---RDAIYQACLLRFRPILMTTLAALLGA 979
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1721271567  996 LPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAYKL---MWLYRHRGKRSQ 1049
Cdd:PRK10503   980 LPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLLfdrLALYTKSRFPRH 1036
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
830-1049 1.97e-10

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 64.88  E-value: 1.97e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  830 DRDMVSVVHDLQQAIGKEVKlkPGISVSYSGQF----ELLERANQKLKLMVPMTLMIIFVLLYLAFRRVGEALLIITSVp 905
Cdd:COG1033    176 DLDRKEVVAEIRAIIAKYED--PGVEVYLTGFPvlrgDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVV- 252
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  906 faLVGGIW---FLYWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHAIEAEPSLEnpqtfsvdkldEALYQgAVLRV- 981
Cdd:COG1033    253 --LLAVIWtlgLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKGLDKR-----------EALRE-ALRKLg 318
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1721271567  982 RPKAMTVAVIIAGLLPILWgtgAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAykLMWLYRHRGKRSQ 1049
Cdd:COG1033    319 PPVLLTSLTTAIGFLSLLF---SDIPPIRDFGIVAAIGVLLAFLTSLTLLPAL--LSLLPRPKPKTRR 381
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
153-508 1.14e-09

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 62.57  E-value: 1.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  153 LAELRSLQDWflkyeLKTIPNVSEVASVGGVVKEYQIVVDPMKLTQYGISlgevksaldasnqeaggSSVELAEAEYMVR 232
Cdd:COG1033    475 LKEIDRLQDY-----LESLPEVGKVLSLADLVKELNQALNEGDPKYYALP-----------------ESRELLAQLLLLL 532
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  233 ASGYLQTLDDFKNivlKTGDNG-VPVYLGDVarvqigpemrrgiaelngegevaggvvilrSGKNAREVISAVKEKLASL 311
Cdd:COG1033    533 SSPPGDDLSRFVD---EDYSAArVTVRLKDL------------------------------DSEEIKALVEEVRAFLAEN 579
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  312 QSslPEGVEV------VTTYDrsqLIDRAIDNLSYKLLEEFIVVALVCALFLWHVRSALVAIISLPLGLCFAFIMMHFQG 385
Cdd:COG1033    580 FP--PDGVEVtltgsaVLFAA---INESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLG 654
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  386 LNANIMSLGGIAIAVGAMVDAAIVMIEnahkRLEEwehqhpgEKLSNDTRWKIITEASVEVGPALFISLLIITLSFIpif 465
Cdd:COG1033    655 IPLNIATAVVASIALGIGVDYTIHFLS----RYRE-------ERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFG--- 720
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1721271567  466 TLegqegkLFGPLAFTK------TWSMAGAALLAIVAIPILMGFWIRGR 508
Cdd:COG1033    721 VL------LFSSFPPLAdfglllALGLLVALLAALLLLPALLLLLDPRI 763
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
827-1048 1.09e-08

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 59.49  E-value: 1.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  827 DARDRDMVSVVHDLQQAIGKEVKLkPGISVSYSGQFELLERANQKL----KLMVPMTLMIIFVLLYLAFRRVGEALLIIT 902
Cdd:COG1033    559 DLDSEEIKALVEEVRAFLAENFPP-DGVEVTLTGSAVLFAAINESViesqIRSLLLALLLIFLLLLLAFRSLRLGLISLI 637
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  903 SVPFALVGGIWFLYWMGFHLSVATGTGF-IALaGVAAEFGVVMLMYLRHAIEAEPSLEnpqtfsvdkldEALYQgaVLRV 981
Cdd:COG1033    638 PNLLPILLTFGLMGLLGIPLNIATAVVAsIAL-GIGVDYTIHFLSRYREERRKGGDLE-----------EAIRR--ALRT 703
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1721271567  982 RPKAMTV--AVIIAGLLPILWgtgAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAykLMWLYRHRGKRS 1048
Cdd:COG1033    704 TGKAILFtsLTLAAGFGVLLF---SSFPPLADFGLLLALGLLVALLAALLLLPAL--LLLLDPRIAKKR 767
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
770-1037 7.73e-07

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 53.30  E-value: 7.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  770 IRYPQSYRDSPETLRQLPILTPLKQqivlgDVAEVKVVTgpSMLKTENAR-----PTSWIYI-----DARDRDMVSVVHD 839
Cdd:TIGR00921   87 KPYVTNVRSAADIMRQIPGNFPLPV-----TMPEVRPLM--SEYPRSKEMflskdHTVAIIIvqlksDADYKQVVPIYND 159
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  840 LQQAI-------GKEVKLKPGISVSYsgQFELLERANQKLKLMVPMTLMIifVLLYLAFRRVGEALLIITSVPFALVGGI 912
Cdd:TIGR00921  160 VERSLertnppsGKFLDVTGSPAINY--DIEREFGKDMGTTMAISGILVV--LVLLLDFKRWWRPLLPLVIILFGVAWVL 235
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  913 WFLYWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHAIEAEPSLENPQTFSVDKLDEALYQGAvlrvrpkAMTVAVII 992
Cdd:TIGR00921  236 GIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIAL-------LTTSAGFA 308
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1721271567  993 AGLLPILwgtgagsEVMSRIAAPMIGGMITAPLLSLFIIPAAYKL 1037
Cdd:TIGR00921  309 ALALSEF-------PMVSEFGLGLVAGLITAYLLTLLVLPALLQS 346
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
6-500 2.62e-04

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 45.28  E-value: 2.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567    6 IRRSVAnRFLVMMAALFLSIwgTWTIIHTPVDALPDLSDVQVIVKTRYPGQAPQ----IVENQVT-WPLTTTMLSVPGAR 80
Cdd:PRK15127   534 ILRSTG-RYLVLYLIIVVGM--AYLFVRLPSSFLPDEDQGVFLTMVQLPAGATQertqKVLNEVTdYYLTKEKNNVESVF 610
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567   81 TVRGFSQFG----DSYVYVIFEDGTDPYWARSRV-------LEYLNQVQG------KLPAGVsaEMGpDATGvgwvFEYA 143
Cdd:PRK15127   611 AVNGFGFAGrgqnTGIAFVSLKDWADRPGEENKVeaitmraTRAFSQIKDamvfafNLPAIV--ELG-TATG----FDFE 683
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  144 LVDRSG-KHD-LAELRSLqdwfLKYELKTIPNVSEVASVGGV--VKEYQIVVDPMKLTQYGISLGEVKSALDASnqeAGG 219
Cdd:PRK15127   684 LIDQAGlGHEkLTQARNQ----LLGEAAKHPDMLVGVRPNGLedTPQFKIDIDQEKAQALGVSISDINTTLGAA---WGG 756
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  220 SSVE------LAEAEYMVRASGYLQTLDDFKNIVLKtGDNG--VPVYLGDVARVQIG-PEMRR--GIAELNGEGEVAggv 288
Cdd:PRK15127   757 SYVNdfidrgRVKKVYVMSEAKYRMLPDDIGDWYVR-AADGqmVPFSAFSSSRWEYGsPRLERynGLPSMEILGQAA--- 832
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  289 vilrSGKNAREVISAVKEklasLQSSLPEGVevvtTYDRSQLI--DRAIDNLSYKLLEEFIVVALVCALFLWHVRS-ALV 365
Cdd:PRK15127   833 ----PGKSTGEAMELMEE----LASKLPTGV----GYDWTGMSyqERLSGNQAPALYAISLIVVFLCLAALYESWSiPFS 900
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  366 AIISLPLGLCFAFIMMHFQGLNANIMSLGGIAIAVGAMVDAAIVMIENAhKRLEEWEHqhpgeklsndtrwKIITEASVE 445
Cdd:PRK15127   901 VMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFA-KDLMDKEG-------------KGLIEATLE 966
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1721271567  446 VGPALFISLLIITLSFI-PIFTLEGQEGKLFGPLAFTKTWSMAG---AALLAIVAIPIL 500
Cdd:PRK15127   967 AVRMRLRPILMTSLAFIlGVMPLVISSGAGSGAQNAVGTGVMGGmvtATVLAIFFVPVF 1025
COG4258 COG4258
Predicted exporter [General function prediction only];
836-1048 1.31e-03

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 42.92  E-value: 1.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  836 VVHDLQQAIGKEVKLKPGISVSYSGQFELLERANQKLK----LMVPMTLMIIFVLLYLAFRRVGEALLIITSVPFALVGG 911
Cdd:COG4258    211 LVAALRAAFAALNAAFPGAQLLLTGAGLFAVAAAQQIKhdisTIGLISLLGILLLLLLVFRSLRPLLLGLLPVAVGALAG 290
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  912 IWFLYWmGF-HLSVAT-GTGFiALAGVAAEFGVVMLMYLRHAIEAEPslenpqtfsvdkldealyQGAVLRVRPkAMTVA 989
Cdd:COG4258    291 LAAVSL-VFgSVHGITlGFGS-SLIGVAVDYSLHYLTHRRAAGEWDP------------------RAALRRIWP-TLLLG 349
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1721271567  990 VI--IAGLLPILWgtgAGSEVMSRIAAPMIGGMITAPLLSLFIIPaayklmWLYRHRGKRS 1048
Cdd:COG4258    350 LLttVLGYLALLF---SPFPGLRQLGVFAAAGLLAAALTTLLWLP------LLLPRAAPRP 401
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
288-514 1.68e-03

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 42.52  E-value: 1.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  288 VVILRSGKNAREVISAVKEKLASLQ-SSLPEGVEVVTTYDRSqlidraidnLSYKLLEEF------------IVVALVCA 354
Cdd:TIGR00921  141 IVQLKSDADYKQVVPIYNDVERSLErTNPPSGKFLDVTGSPA---------INYDIEREFgkdmgttmaisgILVVLVLL 211
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  355 LFLWHVRSALVAIISLPLGLCFAFIMMHFQGLNANIMSLGGIAIAVGAMVDAAIvmieNAHKRLEewEHQHPGEKLSndt 434
Cdd:TIGR00921  212 LDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGI----QTLNRYE--EERDIGRAKG--- 282
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721271567  435 rwKIITEASVEVGPALFISLLIITLSFIPIFTLEGQEGKLFGPLaftktwSMAG---AALLAIVAIPILMGF--WIRGRI 509
Cdd:TIGR00921  283 --EAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLG------LVAGlitAYLLTLLVLPALLQSidIGREKV 354

                   ....*
gi 1721271567  510 PAENS 514
Cdd:TIGR00921  355 KKEII 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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