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Conserved domains on  [gi|1728610717|gb|TXU39678|]
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membrane-bound lytic murein transglycosylase EmtA [Enterobacter roggenkampii]

Protein Classification

membrane-bound lytic murein transglycosylase EmtA( domain architecture ID 11487811)

membrane-bound lytic murein transglycosylase EmtA is a murein-degrading enzyme that may play a role in recycling of muropeptides during cell elongation and/or cell division

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 2.88e-154

membrane-bound lytic murein transglycosylase EmtA;


:

Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 425.15  E-value: 2.88e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717   1 MKLRWFAFLIVLLAGCSSKHDYQNPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGL 80
Cdd:PRK15470    1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  81 MQLKASTAGREVYRYIGWSGQPSTSELKNPERNISMGTAYLSIMEHGVLKGIQDPEVMQYALVVSYVNGAGALLRTFSSD 160
Cdd:PRK15470   81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1728610717 161 RKEAIEEINGMDKDEFFEHVVKNHPAPQAPRYIWKVQKAMDAM 203
Cdd:PRK15470  161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
 
Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 2.88e-154

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 425.15  E-value: 2.88e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717   1 MKLRWFAFLIVLLAGCSSKHDYQNPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGL 80
Cdd:PRK15470    1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  81 MQLKASTAGREVYRYIGWSGQPSTSELKNPERNISMGTAYLSIMEHGVLKGIQDPEVMQYALVVSYVNGAGALLRTFSSD 160
Cdd:PRK15470   81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1728610717 161 RKEAIEEINGMDKDEFFEHVVKNHPAPQAPRYIWKVQKAMDAM 203
Cdd:PRK15470  161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 41-200 3.99e-81

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 238.61  E-value: 3.99e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  41 PISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGREVYRYIGWSGQ-PSTSELKNPERNISMGTA 119
Cdd:cd16893     1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGlPSKSYLFDPENNIDIGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717 120 YLSIMEHGVLKGIQDPEVMQYALVVSYVNGAGALLRTFSSDRKEAIEEINGMDKDEFFEHVVKNHPAPQAPRYIWKVQKA 199
Cdd:cd16893    81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKA 160


                  .
gi 1728610717 200 M 200
Cdd:cd16893   161 K 161
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 23-203 1.95e-31

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 114.32  E-value: 1.95e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  23 QNPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgREVYRYIGWSgqP 102
Cdd:COG0741    87 AELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATA-RRLGLKLGLG--P 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717 103 STSELKNPERNISMGTAYLSIMeHGVLKGiqdpevmQYALVV-SYVNGAGALLRTFSSDRKEAIEEIngmdkdeffehvv 181
Cdd:COG0741   164 SPDDLFDPETNIRAGAAYLREL-LDRFDG-------DLVLALaAYNAGPGRVRRWLRRNGDRDGEII------------- 222

                         170       180
                  ....*....|....*....|..
gi 1728610717 182 knhPAPQAPRYIWKVQKAMDAM 203
Cdd:COG0741   223 ---PYAETRNYVKKVLANYAIY 241
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 45-168 2.15e-28

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 102.77  E-value: 2.15e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  45 QAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGREVYRyigwsGQPSTSELKNPERNISMGTAYLSIM 124
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLR-----VNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1728610717 125 eHGVLKGiqdpevMQYALVVSYVNGAGALLRTFSSDRKEAIEEI 168
Cdd:pfam01464  78 -YKQYGG------DLWLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
 
Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 2.88e-154

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 425.15  E-value: 2.88e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717   1 MKLRWFAFLIVLLAGCSSKHDYQNPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGL 80
Cdd:PRK15470    1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  81 MQLKASTAGREVYRYIGWSGQPSTSELKNPERNISMGTAYLSIMEHGVLKGIQDPEVMQYALVVSYVNGAGALLRTFSSD 160
Cdd:PRK15470   81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1728610717 161 RKEAIEEINGMDKDEFFEHVVKNHPAPQAPRYIWKVQKAMDAM 203
Cdd:PRK15470  161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 41-200 3.99e-81

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 238.61  E-value: 3.99e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  41 PISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGREVYRYIGWSGQ-PSTSELKNPERNISMGTA 119
Cdd:cd16893     1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGlPSKSYLFDPENNIDIGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717 120 YLSIMEHGVLKGIQDPEVMQYALVVSYVNGAGALLRTFSSDRKEAIEEINGMDKDEFFEHVVKNHPAPQAPRYIWKVQKA 199
Cdd:cd16893    81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKA 160


                  .
gi 1728610717 200 M 200
Cdd:cd16893   161 K 161
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
34-199 1.20e-57

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 185.25  E-value: 1.20e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  34 KRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGREVYRYIGWSGQPSTSELKNPERN 113
Cdd:PRK11671  187 KRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRMKGKSGQPSRSYLFDPANN 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717 114 ISMGTAYLSIMEHGVLKGIQDPEVMQYALVVSYVNGAGALLRTFSSDRKEAIEEINGMDKDEFFEHVVKNHPAPQAPRYI 193
Cdd:PRK11671  267 IDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMSPGDVYQTLTTRHPSAESRRYL 346


                  ....*.
gi 1728610717 194 WKVQKA 199
Cdd:PRK11671  347 YKVNTA 352
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 23-203 1.95e-31

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 114.32  E-value: 1.95e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  23 QNPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgREVYRYIGWSgqP 102
Cdd:COG0741    87 AELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATA-RRLGLKLGLG--P 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717 103 STSELKNPERNISMGTAYLSIMeHGVLKGiqdpevmQYALVV-SYVNGAGALLRTFSSDRKEAIEEIngmdkdeffehvv 181
Cdd:COG0741   164 SPDDLFDPETNIRAGAAYLREL-LDRFDG-------DLVLALaAYNAGPGRVRRWLRRNGDRDGEII------------- 222

                         170       180
                  ....*....|....*....|..
gi 1728610717 182 knhPAPQAPRYIWKVQKAMDAM 203
Cdd:COG0741   223 ---PYAETRNYVKKVLANYAIY 241
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 45-168 2.15e-28

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 102.77  E-value: 2.15e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  45 QAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGREVYRyigwsGQPSTSELKNPERNISMGTAYLSIM 124
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLR-----VNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1728610717 125 eHGVLKGiqdpevMQYALVVSYVNGAGALLRTFSSDRKEAIEEI 168
Cdd:pfam01464  78 -YKQYGG------DLWLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 54-124 9.26e-18

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 74.94  E-value: 9.26e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1728610717  54 PRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgrevyryiGWSGQPSTSELKNPERNISMGTAYLSIM 124
Cdd:cd00254     1 PALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTA--------RDLGRRGVDDLFDPEENIRAGARYLREL 63
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 44-122 2.30e-17

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 75.24  E-value: 2.30e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1728610717  44 EQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgREVYRYIGWSGqPSTSELKNPERNISMGTAYLS 122
Cdd:cd16896     9 EKYAKEYGVDPLLVAAVIKVESNFNPNAVSSKGAIGLMQIMPETA-EWIAEKLGLED-FSEDDLYDPETNIRLGTWYLS 85
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 37-122 5.77e-17

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 74.05  E-value: 5.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  37 MQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgREVYRYIGWSGqPSTSELKNPERNISM 116
Cdd:cd13401     4 LPYRDLVERAAKKNGLDPALVYAIIRQESAFDPDAVSPAGALGLMQLMPATA-KDVAKKLGLPY-YSPRDLFDPEYNIRL 81


                  ....*.
gi 1728610717 117 GTAYLS 122
Cdd:cd13401    82 GSAYLA 87
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 44-180 5.08e-15

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 69.10  E-value: 5.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  44 EQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgREVYRyigwsgqpstSELKNPERNISMGTAYLSI 123
Cdd:cd13403     2 KKYAEKYGFDWRLLAAQAYQESRFNPNARSPAGARGLMQLMPSTA-RELGV----------NDRLDPEQNIHAGAKYLRY 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1728610717 124 MEHGVLKGIQDPEVMQYALvVSYVNGAGALLRTfssdRKEAieEINGMDKDEFFEHV 180
Cdd:cd13403    71 LRDRFPPDIDEPDRLKFAL-AAYNAGPGHVRDA----RRLA--KKYGLNPNVWFDNV 120
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 34-179 1.85e-14

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 70.86  E-value: 1.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  34 KRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgrevyRYIGwsgqpsTSELKNPERN 113
Cdd:COG4623   259 GRLPPYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPTGARGLMQLMPATA-----KELG------VDDRLDPEQS 327

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1728610717 114 ISMGTAYLSIMEHGVLKGIQDPEVMQYALvVSYVNGAGALLRtfssDRKEAieEINGMDKDEFFEH 179
Cdd:COG4623   328 IRAGAKYLRWLYDRFPEAIDEPDRWWFAL-AAYNAGPGHVQD----ARRLA--KKQGLDPDRWFDV 386
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 39-121 5.63e-08

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 51.99  E-value: 5.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  39 WMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGREVYRYiGWSGQPSTSELKNPERNISMGT 118
Cdd:PRK11619  479 WNDEFRRYTSGKGIPQSYAMAIARQESAWNPKARSPVGASGLMQIMPGTATHTVKMF-SIPGYSSSSQLLDPETNINIGT 557


                  ...
gi 1728610717 119 AYL 121
Cdd:PRK11619  558 SYL 560
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 50-129 5.31e-07

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 46.37  E-value: 5.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  50 WGVSPRLITAIIAVESGGNPTLVSKSN----AVGLMQLKaSTAGREVYRYigwsGQPSTSELKNPERNISMGTAYLS--I 123
Cdd:cd13400     1 YGVPPRLLRAIAKVESGFNPNAINRNKngsyDIGLMQIN-SIWLPELARY----GITREELLNDPCTNIYVGAWILArnI 75


                  ....*.
gi 1728610717 124 MEHGVL 129
Cdd:cd13400    76 KRYGNT 81
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 50-88 1.14e-04

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 39.98  E-value: 1.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1728610717  50 WGVSPRLITAIIAVESGGNPTLV-SKSNAVGLMQLKASTA 88
Cdd:cd13399     1 YGVPPGILAAILGVESGFGPNAGgSPAGAQGIAQFMPSTW 40
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 34-134 4.63e-04

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 39.51  E-value: 4.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  34 KRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSK-----SNAVGLMQLKAstagrevyRYIGWSGQPSTSElk 108
Cdd:cd01021    32 NRLNKYKDCIKQVGKKLCIDPALIAAIISRESRAGAALDKNgwgdhGNGFGLMQVDK--------RYHPPKGAWDSEE-- 101

                          90       100
                  ....*....|....*....|....*.
gi 1728610717 109 nperNISMGTAYLSIMehgvLKGIQD 134
Cdd:cd01021   102 ----HIEQATGILIDF----IKTVQR 119
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 63-88 9.39e-04

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 37.88  E-value: 9.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 1728610717  63 VESGGNPTLVSKSNAVGLMQLKASTA 88
Cdd:cd16894    16 VESGFNPDAVSSAGAAGLWQFMPATA 41
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
38-154 1.24e-03

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 39.09  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728610717  38 QWMPISEQAGKawGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgrevyryigwsgqpstSELK-----NPER 112
Cdd:PRK10859  289 KYQPLFEKYAG--ELDWRLLAAIAYQESHWNPQATSPTGVRGLMMLTRNTA----------------QSMGvtdrlDPEQ 350

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1728610717 113 NISMGTAYLSIMEHGVLKGIQDPEVMQYALvVSYVNGAGALL 154
Cdd:PRK10859  351 SIRGGARYLQDLMERLPESIPEPERIWFAL-AAYNIGYGHML 391
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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