|
Name |
Accession |
Description |
Interval |
E-value |
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
272-637 |
7.11e-64 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 215.05 E-value: 7.11e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 272 EAMSTALAIEEDSKPLMVSIAPLQSSTALMNCLLKQQDFSNCEVELTLSDGTQAYLLFQGIARYADEQFLGFRGTAINIT 351
Cdd:COG4191 14 LLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 352 SLKLAQLSLEIMNQDLEQqVANRTQDLALSLTRLQETQTQLIESEKLAALGGLVAGVAHEVNTPLGIAVTATSVIQEtre 431
Cdd:COG4191 94 LLLLLAALDAEENAELEE-LERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRR--- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 432 sllnaFNQQTLTSQQFAELMERMtqstlmlETNLNRAARLVRDFKQTAvDQVSEGRSQFHVKQVLDALMASLHSETRKIP 511
Cdd:COG4191 170 -----RLEDEPDPEELREALERI-------LEGAERAAEIVRSLRAFS-RRDEEEREPVDLNELIDEALELLRPRLKARG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 512 VTPQLH-GEDSVMMNSLPGVLTQIMTNLVMNSVnHAFAETAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFF 590
Cdd:COG4191 237 IEVELDlPPDLPPVLGDPGQLEQVLLNLLINAI-DAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1729404602 591 TTKRGQGGSGLGLNLVFNLVKQkLHGQLAFSSEPGHGVHYVITLPQA 637
Cdd:COG4191 316 TTKPVGKGTGLGLSISYGIVEK-HGGRIEVESEPGGGTTFTITLPLA 361
|
|
| CHASE5 |
pfam17149 |
Periplasmic sensor domain found in signal transduction proteins; CHASE5 is a conserved ... |
45-151 |
1.57e-54 |
|
Periplasmic sensor domain found in signal transduction proteins; CHASE5 is a conserved periplasmic sensor domain found in histidine kinases, diguanylate cyclases/phosphodiesterases and methyl-accepting chemotaxis proteins. In Pseudomonas aeruginosa, CHASE5 is the sensor domain in the c-di-GMP phosphodiesterase BifA that regulates biofilm formation and in sensor kinase AruS that regulates arginine degradation pathways. These results suggest that CHASE5 might bind arginine or a related compound.
Pssm-ID: 319167 Cd Length: 108 Bit Score: 181.25 E-value: 1.57e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 45 DYNREFNNVQARHDEIQTIHAELLASSLWNYDLVVLTQRLEGLVNLPNVDYMKITS-GDYHFSAGEPVTSMALNSEIALE 123
Cdd:pfam17149 1 DYRREVSRIDRRFDEIEKANLDVLAASLWNIDERLLNTQLNGLIQLPDINYISIKDdSGQSWNAGEPKTTHTLNKIFPLV 80
|
90 100
....*....|....*....|....*...
gi 1729404602 124 YTNPDTQVTENIGTLYVESDAQGIYNYL 151
Cdd:pfam17149 81 YKSPTDNIARNIGTLEVEVDMDAIYQRL 108
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
239-635 |
2.05e-34 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 134.20 E-value: 2.05e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 239 TIKSEQERLEDFAQAASDWLWETNCHGELIYSSEAMSTALAIEEDS---KPLMVSIAPLQS-STALMNCLLKQQDFSNCE 314
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEEllgRPLAELFPEDSPlRELLERALAEGQPVTERE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 315 VELTLSDGTQAYLLFQgIARYADEQflgfrgtainitslklAQLSLEIMNQDLEQQVanrtqdlalsltRLQEtqtQLIE 394
Cdd:COG3852 81 VTLRRKDGEERPVDVS-VSPLRDAE----------------GEGGVLLVLRDITERK------------RLER---ELRR 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 395 SEKLAALGGLVAGVAHEVNTPLGIAVTATSVIQetresllnafnqQTLTSQQFAELMERMTQSTlmletnlNRAARLVRD 474
Cdd:COG3852 129 AEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLE------------RELPDDELREYTQLIIEEA-------DRLNNLVDR 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 475 FKQTAVDQVSEgRSQFHVKQVLDALMASLHSETRKiPVTPQLHGEDS---VMMNslPGVLTQIMTNLVMNSVnHAFAET- 550
Cdd:COG3852 190 LLSFSRPRPPE-REPVNLHEVLERVLELLRAEAPK-NIRIVRDYDPSlpeVLGD--PDQLIQVLLNLVRNAA-EAMPEGg 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 551 -------AQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKrgQGGSGLGLNLVFNLVKQkLHGQLAFSSE 623
Cdd:COG3852 265 titirtrVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTK--EKGTGLGLAIVQKIVEQ-HGGTIEVESE 341
|
410
....*....|..
gi 1729404602 624 PGHGVHYVITLP 635
Cdd:COG3852 342 PGKGTTFRIYLP 353
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
150-637 |
5.18e-34 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 134.70 E-value: 5.18e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 150 YLIRQFLLTLAVNALKTAIVCYLILLIFHASVNQRIFAIAQFLRR-----YNPRHPKKplqlpfnpwimeKNDELQWLGD 224
Cdd:COG5000 2 GLQILFLLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAvaagdLSVRLPVT------------GDDEIGELAR 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 225 ETNRIANNVTTLYRTIKSEQERLEDFAQAASDWLWETNCHGELIYSSEAMSTALAIEEDS---KPLMVSIAPLQSSTALM 301
Cdd:COG5000 70 AFNRMTDQLKEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEEligKPLEELLPELDLAELLR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 302 NCLLKQQDFsncevELTLSDGTQAYLLFQGIARYADEQFLGFrgtainitslklaqlsleimnqdleqqvanrtQDLals 381
Cdd:COG5000 150 EALERGWQE-----EIELTRDGRRTLLVRASPLRDDGYVIVF--------------------------------DDI--- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 382 ltrlqetqTQLIESEKLAALGGLVAGVAHEVNTPLgiavtatSVIQETRESLLNAFNQQTltsQQFAELMERMTQstlML 461
Cdd:COG5000 190 --------TELLRAERLAAWGELARRIAHEIKNPL-------TPIQLSAERLRRKLADKL---EEDREDLERALD---TI 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 462 ETNLNRAARLVRDFKQTAVDQVSEgRSQFHVKQVLD---ALMASLHSEtRKIPVTPQLHGED-SVMMNslPGVLTQIMTN 537
Cdd:COG5000 249 IRQVDRLKRIVDEFLDFARLPEPQ-LEPVDLNELLRevlALYEPALKE-KDIRLELDLDPDLpEVLAD--RDQLEQVLIN 324
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 538 LVMNSVnHAFAEtaQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKrgQGGSGLGLNLVFNLVKQkLHGQ 617
Cdd:COG5000 325 LLKNAI-EAIEE--GGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTK--PKGTGLGLAIVKKIVEE-HGGT 398
|
490 500
....*....|....*....|
gi 1729404602 618 LAFSSEPGHGVHYVITLPQA 637
Cdd:COG5000 399 IELESRPGGGTTFTIRLPLA 418
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
314-635 |
4.94e-32 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 126.95 E-value: 4.94e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 314 EVELTLSDGTQAYLLFQGIARYADEQFLGFRGTAINITSLKLAQLSLEIMNQDLEQQVANRTQDLALSLTRLQETQTQLI 393
Cdd:COG0642 24 LLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 394 EsEKLAALGGLVAGVAHEVNTPLGIAVTATSVIQETresllnafnqqtlTSQQFAELMERMtqstlmlETNLNRAARLVR 473
Cdd:COG0642 104 E-EANEAKSRFLANVSHELRTPLTAIRGYLELLLEE-------------LDEEQREYLETI-------LRSADRLLRLIN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 474 DFKQTA---VDQVSEGRSQFHVKQVLDALMASLHSETRKIPVTPQLHGEDSV-MMNSLPGVLTQIMTNLVMNSVNHAFAE 549
Cdd:COG0642 163 DLLDLSrleAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTPEG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 550 TaqpEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTK--RGQGGSGLGLNLVFNLVkQKLHGQLAFSSEPGHG 627
Cdd:COG0642 243 G---TVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDpsRRGGGTGLGLAIVKRIV-ELHGGTIEVESEPGKG 318
|
....*...
gi 1729404602 628 VHYVITLP 635
Cdd:COG0642 319 TTFTVTLP 326
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
384-637 |
2.20e-31 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 122.32 E-value: 2.20e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 384 RLQETQTQLIESEKLaaLGGLVAGVAHEVNTPLGIAVTATSVIQEtresllnafnQQTLTSQQFAELMERMTQSTlmlet 463
Cdd:COG2205 1 ELEEALEELEELERL--KSEFLANVSHELRTPLTSILGAAELLLD----------EEDLSPEERRELLEIIRESA----- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 464 nlNRAARLVRDFKQTAvdQVSEGRSQFH-----VKQVLDALMASLHSETRKIPVTPQLH-GEDSVMMNSLPGVLTQIMTN 537
Cdd:COG2205 64 --ERLLRLIEDLLDLS--RLESGKLSLElepvdLAELLEEAVEELRPLAEEKGIRLELDlPPELPLVYADPELLEQVLAN 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 538 LVMNSVNHAFAETaqpEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTK--RGQGGSGLGLNLVFNLVkQKLH 615
Cdd:COG2205 140 LLDNAIKYSPPGG---TITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDnsRGEGGTGLGLAIVKRIV-EAHG 215
|
250 260
....*....|....*....|..
gi 1729404602 616 GQLAFSSEPGHGVHYVITLPQA 637
Cdd:COG2205 216 GTIWVESEPGGGTTFTVTLPLA 237
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
528-635 |
1.28e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 101.34 E-value: 1.28e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 528 PGVLTQIMTNLVMNSVNhafAETAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRGQGGSGLGLNLVF 607
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQ---AMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSY 77
|
90 100
....*....|....*....|....*...
gi 1729404602 608 NLVkQKLHGQLAFSSEPGHGVHYVITLP 635
Cdd:cd16943 78 RII-QKHGGTIRVASVPGGGTRFTIILP 104
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
324-637 |
1.68e-25 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 108.87 E-value: 1.68e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 324 QAYLLFQGIARYADEQFLGFRGTAINITSLKLAQLSLEIMNQDLEQQVANRTQDLALSLTRLQETQTQLIESEKLAALgg 403
Cdd:COG5002 90 LLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRRE-- 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 404 LVAGVAHEVNTPLgiavtatSVIQETRESLLNAFNQQTLTSQQFAELMERmtqstlmletNLNRAARLVRDFKQTAvdQV 483
Cdd:COG5002 168 FVANVSHELRTPL-------TSIRGYLELLLDGAADDPEERREYLEIILE----------EAERLSRLVNDLLDLS--RL 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 484 SEGRSQFHVKQV-LDALM------ASLHSETRKIPVTPQLHGED-SVMMNslPGVLTQIMTNLVMNSVNHAFAETaqpEI 555
Cdd:COG5002 229 ESGELKLEKEPVdLAELLeevveeLRPLAEEKGIELELDLPEDPlLVLGD--PDRLEQVLTNLLDNAIKYTPEGG---TI 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 556 DIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTK----RGQGGSGLGLNLVFNLVkQKLHGQLAFSSEPGHGVHYV 631
Cdd:COG5002 304 TVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDksrsRETGGTGLGLAIVKHIV-EAHGGRIWVESEPGKGTTFT 382
|
....*.
gi 1729404602 632 ITLPQA 637
Cdd:COG5002 383 ITLPLA 388
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
531-635 |
2.30e-25 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 100.80 E-value: 2.30e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHAFAETaqpEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTK---RGQGGSGLGLNLVF 607
Cdd:smart00387 6 LRQVLSNLLDNAIKYTPEGG---RITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsRKIGGTGLGLSIVK 82
|
90 100
....*....|....*....|....*...
gi 1729404602 608 NLVkQKLHGQLAFSSEPGHGVHYVITLP 635
Cdd:smart00387 83 KLV-ELHGGEISVESEPGGGTTFTITLP 109
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
382-635 |
1.40e-24 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 108.52 E-value: 1.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 382 LTRLQETQTQLIESEKLAALGGLVAGVAHEVNTPLgiavTATS-VIQ---------ETRESL---------LNAFNQQTL 442
Cdd:PRK11360 371 LTERKRLQRRVARQERLAALGELVAGVAHEIRNPL----TAIRgYVQiwrqqtsdpPSQEYLsvvlrevdrLNKVIDQLL 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 443 tsqQFAelmeRMTQSTlMLETNLNRAARLVRDFKQTAVDQVsegRSQFHVKqvldalmasLHSETRKIPVTPQLhgedsv 522
Cdd:PRK11360 447 ---EFS----RPRESQ-WQPVSLNALVEEVLQLFQTAGVQA---RVDFETE---------LDNELPPIWADPEL------ 500
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 523 mmnslpgvLTQIMTNLVMNSVnHAFAETAQPEIDIHfYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKrgQGGSGLG 602
Cdd:PRK11360 501 --------LKQVLLNILINAV-QAISARGKIRIRTW-QYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTK--AKGTGLG 568
|
250 260 270
....*....|....*....|....*....|...
gi 1729404602 603 LNLVFNLVkQKLHGQLAFSSEPGHGVHYVITLP 635
Cdd:PRK11360 569 LALSQRII-NAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
382-635 |
1.74e-24 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 107.51 E-value: 1.74e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 382 LTRLQETQTQLIESEKLAALGGLVAGVAHEVNTPLgiavtaTSV------IQETREsllnafnqqtlTSQQFAELMErmt 455
Cdd:COG5805 268 ITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPL------TSIkgflqlLQPGIE-----------DKEEYFDIML--- 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 456 qstlmleTNLNRAARLVRDFKQTAVDQvSEGRSQFHVKQVLDALMASLHSETRKIPVTPQLHGEDSVMMNSL-PGVLTQI 534
Cdd:COG5805 328 -------SELDRIESIISEFLALAKPQ-AVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCdENQIKQV 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 535 MTNLVMNSVNhafaetAQP---EIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKrgQGGSGLGLNLVFNLVK 611
Cdd:COG5805 400 FINLIKNAIE------AMPnggTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTK--EKGTGLGLMVSYKIIE 471
|
250 260
....*....|....*....|....
gi 1729404602 612 QKlHGQLAFSSEPGHGVHYVITLP 635
Cdd:COG5805 472 NH-NGTIDIDSKVGKGTTFTITLP 494
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
531-634 |
3.43e-24 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 97.29 E-value: 3.43e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHAFAETaqpEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTK--RGQGGSGLGLNLVFN 608
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGG---TIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDksREGGGTGLGLAIVRR 77
|
90 100
....*....|....*....|....*.
gi 1729404602 609 LVKQkLHGQLAFSSEPGHGVHYVITL 634
Cdd:cd00075 78 IVEA-HGGRITVESEPGGGTTFTVTL 102
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
382-635 |
1.19e-23 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 102.94 E-value: 1.19e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 382 LTRLQETQTQLIESEKLAALGGLVAGVAHEVNTPLGIAVTATSVIQETREsllnafnqqTLTSQQFAELMErmtqstlml 461
Cdd:COG5807 128 ITKRKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQLLQESRE---------DSEREEYFNIII--------- 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 462 eTNLNRAARLVRDFKQTAVDQvSEGRSQFHVKQVLDALMASLHSETRKIPVTPQLHGEDSV-MMNSLPGVLTQIMTNLVM 540
Cdd:COG5807 190 -SEIDRINTIITELLVLSKPK-KFNFKKLNLNDVLEDVIALLSTEAILKNISIKYDLADDEpVINGDKNQLKQVFINLIK 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 541 NSVNhafAETAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKrgQGGSGLGLNLVFNLVKQklH-GQLA 619
Cdd:COG5807 268 NAIE---AMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTK--EEGTGLGLSICKKIIEE--HnGTIE 340
|
250
....*....|....*.
gi 1729404602 620 FSSEPGHGVHYVITLP 635
Cdd:COG5807 341 VESKPGKGTTFTIYLP 356
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
240-642 |
3.98e-23 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 103.13 E-value: 3.98e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 240 IKSEQERLEDFAQAASDWLWETNCHGELIYSSEAMSTALAIEEDS---KPL--MVSIAPLQSSTALMNCLLKQQDFSNCE 314
Cdd:COG5809 136 LRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEEligKSIleLIHSDDQENVAAFISQLLKDGGIAQGE 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 315 VELTLSDGTQAYLLFQGIARYADEQFLGFRGTAINITSLKlaqlsleimnqdleqqvanrtqdlalsltrlqETQTQLIE 394
Cdd:COG5809 216 VRFWTKDGRWRLLEASGAPIKKNGEVDGIVIIFRDITERK--------------------------------KLEELLRK 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 395 SEKLAALGGLVAGVAHEVNTPLgiavtaTSV---IQETRESLLNAfnqqtltSQQFAELM----ERMTQST---LMLetn 464
Cdd:COG5809 264 SEKLSVVGELAAGIAHEIRNPL------TSLkgfIQLLKDTIDEE-------QKTYLDIMlselDRIESIIsefLVL--- 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 465 lnrAARLVRDFKQTAVDQVsegrsqfhVKQVLD-----ALMASLHSETRKIPVTPQLHGEdsvmmnslPGVLTQIMTNLV 539
Cdd:COG5809 328 ---AKPQAIKYEPKDLNTL--------IEEVIPllqpqALLKNVQIELELEDDIPDILGD--------ENQLKQVFINLL 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 540 MNSVnHAFAEtaQPEIDIHFYQKDQ-QIIIEYRDNGCGVAKELHQKIFEPFFTTKrgQGGSGLGLNLVFNLVKQKlHGQL 618
Cdd:COG5809 389 KNAI-EAMPE--GGNITIETKAEDDdKVVISVTDEGCGIPEERLKKLGEPFYTTK--EKGTGLGLMVSYKIIEEH-GGKI 462
|
410 420
....*....|....*....|....
gi 1729404602 619 AFSSEPGHGVHYVITLPQALSMPQ 642
Cdd:COG5809 463 TVESEVGKGTTFSITLPIKLSEQV 486
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
531-635 |
3.16e-22 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 92.05 E-value: 3.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHAfaeTAQPEIDIHFyQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTT-KRGQGGSGLGLNLVFNL 609
Cdd:pfam02518 6 LRQVLSNLLDNALKHA---AKAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTAdKRGGGGTGLGLSIVRKL 81
|
90 100
....*....|....*....|....*.
gi 1729404602 610 VKQkLHGQLAFSSEPGHGVHYVITLP 635
Cdd:pfam02518 82 VEL-LGGTITVESEPGGGTTVTLTLP 106
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
243-637 |
9.07e-20 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 92.93 E-value: 9.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 243 EQERLEDFAQAASDWLWETNCHGELIYSSEAMSTALAIEEDSKPLMVSIAPLQSSTALMNCLLKQQDFSNCEVELTLSDG 322
Cdd:COG4251 140 LALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLL 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 323 TQAYLLFQGIARYADEQFLGFRGTAINITSLKLAQLSLEIMNQDLEQQVANRTQDLALSLTRLQEtqtqlieseklaalg 402
Cdd:COG4251 220 SLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQ--------------- 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 403 gLVAGVAHEVNTPLGIAVTATSVIQETRESLLNAFNQQTLTS-QQFAELMERMTQSTLmletNLNRAARLVRDFKQTAVD 481
Cdd:COG4251 285 -FAYVASHDLREPLRKISGFSQLLEEDYGDKLDEEGREYLERiRDAAERMQALIDDLL----AYSRVGRQELEFEPVDLN 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 482 QVsegrsqfhVKQVLDALMASLhsETRKIPVT----PQLHGeDSVMMNslpgvltQIMTNLVMNSVNHAfAETAQPEIDI 557
Cdd:COG4251 360 EL--------LEEVLEDLEPRI--EERGAEIEvgplPTVRG-DPTLLR-------QVFQNLISNAIKYS-RPGEPPRIEI 420
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 558 HFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFT--TKRGQGGSGLGLNLVFNLVkQKLHGQLAFSSEPGHGVHYVITLP 635
Cdd:COG4251 421 GAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRlhSRDEYEGTGIGLAIVKKIV-ERHGGRIWVESEPGEGATFYFTLP 499
|
..
gi 1729404602 636 QA 637
Cdd:COG4251 500 KA 501
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
367-642 |
9.49e-20 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 93.94 E-value: 9.49e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 367 LEQQVANRTQdlALSLTRLQETQTQLIESEKLAAlgglvagVAHEVNTPLGIAVTATSVIQETresllnafnqqTLTSQQ 446
Cdd:PRK15347 373 LENKVAERTQ--ALAEAKQRAEQANKRKSEHLTT-------ISHEIRTPLNGVLGALELLQNT-----------PLTAEQ 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 447 FaELMERMTQSTLMLETNLNRaarlVRDFKQTAVDQVSEGRSQFHVKQVLDALMASLHSETRKIPVTPQLHGEDSV---- 522
Cdd:PRK15347 433 M-DLADTARQCTLSLLAIINN----LLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVplyl 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 523 MMNSLPgvLTQIMTNLVMNSVNhaFAETAqpEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRGQGGSGLG 602
Cdd:PRK15347 508 HLDSLR--LRQILVNLLGNAVK--FTETG--GIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLG 581
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1729404602 603 LNLVFNLVKqKLHGQLAFSSEPGHGVHYVITLP-QALSMPQ 642
Cdd:PRK15347 582 LTIASSLAK-MMGGELTLFSTPGVGSCFSLVLPlNEYAPPE 621
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
531-635 |
1.65e-17 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 84.90 E-value: 1.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHA-FAETAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRGqGGSGLGLNLVFNL 609
Cdd:COG3290 282 LVTILGNLLDNAIEAVeKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLG-EGRGLGLALVKQI 360
|
90 100
....*....|....*....|....*.
gi 1729404602 610 VKqKLHGQLAFSSEPGHGVHYVITLP 635
Cdd:COG3290 361 VE-KYGGTIEVESEEGEGTVFTVRLP 385
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
384-635 |
2.42e-17 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 85.19 E-value: 2.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 384 RLQETQTQLIESEKLAALGGLVAGVAHEVNTPLgiavtaTSVIqetresllnAFNQqtLTSQQFAELMERMTQSTLMLEt 463
Cdd:COG5808 224 TLLERVIQEINTQKLELIGTFAASTAHEIRNPL------TSIK---------GFIQ--LLQEKYPELEDQKYFDIIQEE- 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 464 nLNRAARLVRDF----KQTAVD-QVSEgrsqfhVKQVLDALMASLHSETRKIPVTPQLH-GEDSVMMNSLPGVLTQIMTN 537
Cdd:COG5808 286 -IQRINQIVSEFlvlgKPTAKKlELDD------LNELIEEILSIIDSEANLKNIRVEKQsLDEPLHIKCDKDRIKQVLLN 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 538 LVMNSVNhafAETAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKrgQGGSGLGLNLVFNLVkQKLHGQ 617
Cdd:COG5808 359 LIKNAIE---AMKEGGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTK--EGGTGLGLSVCKRIV-EMHGGE 432
|
250
....*....|....*...
gi 1729404602 618 LAFSSEPGHGVHYVITLP 635
Cdd:COG5808 433 IDIESEEGKGTTFTIRLP 450
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-635 |
1.45e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 75.40 E-value: 1.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNhAFAETAQP--EIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKrGQGGSGLGLNLVFN 608
Cdd:cd16915 1 LITIVGNLIDNALD-ALAATGAPnkQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTK-GQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*..
gi 1729404602 609 LVKQkLHGQLAFSSEPGHGVHYVITLP 635
Cdd:cd16915 79 SVER-LGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
386-635 |
3.77e-16 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 81.37 E-value: 3.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 386 QETQTQLIESEKLAALGGLVAGVAHEVNTPLgiavtatSVIQetreSLLNAFNQQTLT---SQQFAELM----ERMTQS- 457
Cdd:PRK10364 222 QLLQDEMKRKEKLVALGHLAAGVAHEIRNPL-------SSIK----GLAKYFAERAPAggeAHQLAQVMakeaDRLNRVv 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 458 TLMLE----TNLNRAARLVRDFKQTAVDQVS-EGRS-----QFHVKQVLDALMASlhsetrkipvtpqlhgedsvmmnsl 527
Cdd:PRK10364 291 SELLElvkpTHLALQAVDLNDLINHSLQLVSqDANSreiqlRFTANDTLPEIQAD------------------------- 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 528 PGVLTQIMTNLVMNSVnHAFAEtaQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKrGQgGSGLGLNLVF 607
Cdd:PRK10364 346 PDRLTQVLLNLYLNAI-QAIGQ--HGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTK-AE-GTGLGLAVVH 420
|
250 260
....*....|....*....|....*....
gi 1729404602 608 NLVKQklH-GQLAFSSEPGHGVHYVITLP 635
Cdd:PRK10364 421 NIVEQ--HgGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-634 |
1.60e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 72.49 E-value: 1.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNhAFAETAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRGQGGSGLGLNLVFNLV 610
Cdd:cd16976 1 IQQVLMNLLQNALD-AMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIV 79
|
90 100
....*....|....*....|....
gi 1729404602 611 kQKLHGQLAFSSEPGHGVHYVITL 634
Cdd:cd16976 80 -EEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
531-635 |
2.23e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 72.53 E-value: 2.23e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNhaFaeTAQPEIDIH-----FYQKDQQIIIEYRDNGCGVAKELHQKIFEPFF----TTKRGQGGSGL 601
Cdd:cd16922 1 LRQILLNLLGNAIK--F--TEEGEVTLRvsleeEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSqadsSTTRKYGGTGL 76
|
90 100 110
....*....|....*....|....*....|....*
gi 1729404602 602 GLNLVFNLVkqKLH-GQLAFSSEPGHGVHYVITLP 635
Cdd:cd16922 77 GLAISKKLV--ELMgGDISVESEPGQGSTFTFTLP 109
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
364-622 |
7.72e-14 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 74.72 E-value: 7.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 364 NQDLEQQVANRTQDLAlsltRLQETQTQLIESEKLAALGGLVAGVAHEVNTPLGIAVT-----ATSVIQETRESLLNAFN 438
Cdd:COG4192 400 TQELETEIEERKRIEK----NLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMylfsaKKALEQENYAQLPTSLD 475
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 439 qqtltsqQFAELMERMtqstlmletnlNRAARLVRDFKQTAVDQVSEGRsqfhVKQVLDALMASLhsETRKIPVTPQLHG 518
Cdd:COG4192 476 -------KIEGLIERM-----------DKIIKSLRQFSRKSDTPLQPVD----LRQVIEQAWELV--ESRAKPQQITLHI 531
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 519 EDSVMMNSLPGVLTQIMTNLVMNSVNhafAETAQPEIDIHFYQKDQQIIIEYRDNGCGVAkeLHQKIFEPFFTTKrgQGG 598
Cdd:COG4192 532 PDDLMVQGDQVLLEQVLVNLLVNALD---AVATQPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFTTTK--EVG 604
|
250 260
....*....|....*....|....
gi 1729404602 599 SGLGLNLVFNLVKQkLHGQLAFSS 622
Cdd:COG4192 605 LGLGLSICRSIMQQ-FGGDLYLAS 627
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
566-635 |
9.29e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 67.79 E-value: 9.29e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 566 IIIEYRDNGCGVAKELHQKIFEPFFTTKRGQGGSGLGLNLVFNLVKQkLHGQLAFSSEPGHGVHYVITLP 635
Cdd:cd16919 48 VCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKGTGLGLSMVYGFVKQ-SGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-635 |
6.14e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 65.42 E-value: 6.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHAfaetaqPE-IDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTT----KRGQGGSGLGLNL 605
Cdd:cd16949 1 LARALENVLRNALRYS------PSkILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVdsarDRESGGTGLGLAI 74
|
90 100 110
....*....|....*....|....*....|
gi 1729404602 606 VFNLVKQKlHGQLAFSSEPGHGVHYVITLP 635
Cdd:cd16949 75 AERAIEQH-GGKIKASNRKPGGLRVRIWLP 103
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
484-635 |
2.69e-12 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 69.55 E-value: 2.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 484 SEGRSQFHVKQVLDALMASLHSETRKIPVTPQLHGEDsVMMNS---LPgvLTQIMTNLVMNSVNHAFAETAQPEIDIHFY 560
Cdd:COG3920 353 SEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPD-VELPAdaaVP--LGLILNELVTNALKHAFLSGEGGRIRVSWR 429
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1729404602 561 QKDQQIIIEYRDNGCGvakelhqkiFEPFFTTKRgqgGSGLGLNLVFNLVKQkLHGQLAFssEPGHGVHYVITLP 635
Cdd:COG3920 430 REDGRLRLTVSDNGVG---------LPEDVDPPA---RKGLGLRLIRALVRQ-LGGTLEL--DRPEGTRVRITFP 489
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
406-635 |
6.51e-12 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 68.12 E-value: 6.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 406 AGVAHEVNTPLGIAVTATSVIQETreslLNAFNQQTLTSQQfAELmermtqSTLmletnlnraARLVRDFKQTAVDqvSE 485
Cdd:PRK10549 245 ADISHELRTPLAVLRGELEAIQDG----VRKFTPESVASLQ-AEV------GTL---------TKLVDDLHQLSLS--DE 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 486 G-----RSQFHVKQVLDALMASLHSETRKIPVTPQLHGEDSVMMNSLPGVLTQIMTNLVMNSVNHAfaeTAQPEIDIHFY 560
Cdd:PRK10549 303 GalayrKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYT---DSGGSLHISAE 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 561 QKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTK----RGQGGSGLGLNLVFNLVKQklH-GQLAFSSEPGHGVHYVITLP 635
Cdd:PRK10549 380 QRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEgsrnRASGGSGLGLAICLNIVEA--HnGRIIAAHSPFGGVSITVELP 457
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-635 |
1.11e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 61.57 E-value: 1.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHAfAETAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPF--FTTKRGQGGSGLGLNLVFN 608
Cdd:cd16921 1 LGQVLTNLLGNAIKFR-RPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFqrLHSREEYEGTGVGLAIVRK 79
|
90 100
....*....|....*....|....*...
gi 1729404602 609 LVKQklH-GQLAFSSEPGHGVHYVITLP 635
Cdd:cd16921 80 IIER--HgGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
409-637 |
1.56e-11 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 66.79 E-value: 1.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 409 AHEVNTPLGIAVTATSVIQE-----TRESLLNAFNQQTLTSQQfaeLMERMtqstLMLetnlnraARLvrdfkqtavdqv 483
Cdd:PRK11100 264 THELKSPLAAIRGAAELLQEdpppeDRARFTGNILTQSARLQQ---LIDRL----LEL-------ARL------------ 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 484 sEGRSQFH------VKQVLDALMASLHSETRKIPVTPQLHGEDSVMMNSlPGVLTQIMTNLVMNSVnhAFAEtAQPEIDI 557
Cdd:PRK11100 318 -EQRQELEvlepvaLAALLEELVEAREAQAAAKGITLRLRPDDARVLGD-PFLLRQALGNLLDNAI--DFSP-EGGTITL 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 558 HFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKR---GQGGSGLGLnlvfNLVKQ--KLH-GQLAFSSEPGHGVHYV 631
Cdd:PRK11100 393 SAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSLPRpanGRKSTGLGL----AFVREvaRLHgGEVTLRNRPEGGVLAT 468
|
....*.
gi 1729404602 632 ITLPQA 637
Cdd:PRK11100 469 LTLPRH 474
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-635 |
1.97e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 60.94 E-value: 1.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHAfaeTAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTT----KRGQGGSGLGLNLV 606
Cdd:cd16946 5 LQQLFVNLLENSLRYT---DTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVessrNRASGGSGLGLAIC 81
|
90 100
....*....|....*....|....*....
gi 1729404602 607 FNLVkQKLHGQLAFSSEPGHGVHYVITLP 635
Cdd:cd16946 82 HNIA-LAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
530-635 |
4.15e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 59.99 E-value: 4.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 530 VLTQIMTNlvmnsvnhAFAETAQP-EIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRG---QGGSGLGLNL 605
Cdd:cd16948 9 IIGQIVSN--------ALKYSKQGgKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGrnfQESTGMGLYL 80
|
90 100 110
....*....|....*....|....*....|
gi 1729404602 606 VfNLVKQKLHGQLAFSSEPGHGVHYVITLP 635
Cdd:cd16948 81 V-KKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-635 |
7.29e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 59.33 E-value: 7.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHAFAETAQP-EIDIHFYQKDQQ-IIIEYRDNGCGVAKELHQKIFEPFFTTKrgQGGSGLGLNLVFN 608
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCERrELTIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFYTTK--SEGLGMGLSICRS 78
|
90 100
....*....|....*....|....*..
gi 1729404602 609 LVKQKlHGQLAFSSEPGHGVHYVITLP 635
Cdd:cd16920 79 IIEAH-GGRLSVESPAGGGATFQFTLP 104
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
371-627 |
7.99e-11 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 65.08 E-value: 7.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 371 VANRTQDLA------LSLTRLQETQTQLIESEKLAALGGLVAGVAHEVNTPLgiavtatSVIQETRESLLNAFNQQTLTS 444
Cdd:PRK13557 127 VYNDAGDLVyffgsqLDVSRRRDAEDALRQAQKMEALGQLTGGIAHDFNNLL-------QVMSGYLDVIQAALSHPDADR 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 445 QqfaelmeRMTQSTLMLETNLNRAARLVRDFKQTAVDQVSEGRSQfhvkqVLDAL---MASLHSETRkipvtpqlhGEDS 521
Cdd:PRK13557 200 G-------RMARSVENIRAAAERAATLTQQLLAFARKQRLEGRVL-----NLNGLvsgMGELAERTL---------GDAV 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 522 VMMNSL-PGVL------TQIMTNLV---------MNSVNHAFAETAQPEI---DIHFYQK---DQQIIIEYRDNGCGVAK 579
Cdd:PRK13557 259 TIETDLaPDLWncridpTQAEVALLnvlinardaMPEGGRVTIRTRNVEIedeDLAMYHGlppGRYVSIAVTDTGSGMPP 338
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1729404602 580 ELHQKIFEPFFTTKRGQGGSGLGLNLVFNLVKQKlHGQLAFSSEPGHG 627
Cdd:PRK13557 339 EILARVMDPFFTTKEEGKGTGLGLSMVYGFAKQS-GGAVRIYSEVGEG 385
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-635 |
8.27e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 59.34 E-value: 8.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVnHAFAETaQPEIDIH-FYQKDQQI---------IIEYRDNGCGVAKELHQKIFEPFFTTKrgQGGSG 600
Cdd:cd16918 1 LIQVFLNLVRNAA-QALAGS-GGEIILRtRTQRQVTLghprhrlalRVSVIDNGPGIPPDLQDTIFYPMVSGR--ENGTG 76
|
90 100 110
....*....|....*....|....*....|....*.
gi 1729404602 601 LGLNLVFNLVKQklH-GQLAFSSEPGHGVhYVITLP 635
Cdd:cd16918 77 LGLAIAQNIVSQ--HgGVIECDSQPGHTV-FSVSLP 109
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
365-635 |
1.09e-10 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 64.93 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 365 QDLEQQVANRTQDL-ALSLTRLQETQtqliESEKLA-ALGGLVAGVAHEVNTPL-GIAVTATsviqetreslLNAFNQqt 441
Cdd:PRK11466 410 EQLAAQVKARTAELqELVIEHRQARA----EAEKASqAKSAFLAAMSHEIRTPLyGILGTAQ----------LLADNP-- 473
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 442 lTSQQFAELMERMTQSTLMLETNLNRaarlVRDFKQTAV--DQVSEGRSQFHVKQVLDALMASLHSETRKIPVTpQLHGE 519
Cdd:PRK11466 474 -ALNAQRDDLRAITDSGESLLTILND----ILDYSAIEAggKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIR-LATDI 547
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 520 DSVMMNSLPGVLTQImTNLVMNSVNHAFAETAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRGQGGS 599
Cdd:PRK11466 548 ADDLPTALMGDPRRI-RQVITNLLSNALRFTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGGT 626
|
250 260 270
....*....|....*....|....*....|....*.
gi 1729404602 600 GLGLNLVFNLVkQKLHGQLAFSSEPGHGVHYVITLP 635
Cdd:PRK11466 627 GLGLTISSRLA-QAMGGELSATSTPEVGSCFCLRLP 661
|
|
| ActS_PrrB_HisK |
NF033792 |
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ... |
370-605 |
2.22e-10 |
|
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.
Pssm-ID: 468186 [Multi-domain] Cd Length: 423 Bit Score: 62.92 E-value: 2.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 370 QVANRTQDLALSLTrlqETQTQLIESEKLAALGGLVAGVAHEVNTPLG-IAVTATSVIQETRES--------LLnafNQQ 440
Cdd:NF033792 174 RVAEEARRLSDALA---ATELVLAREQHLSALDGLAAAAAHELGTPLAtIALVAKELERELPDDpplredaeLL---RSQ 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 441 T---------LTSQQFA--ELMERMTQSTLMLEtnlnrAARLVRDF-KQTAVDQVSEGRSQfhvkqvldalmaslhsetr 508
Cdd:NF033792 248 AercrdilrrLTSLGEEgdAHLDRLPLSALIEE-----AAAPHRGFgKEIEVVVAGDPGEE------------------- 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 509 kiPVTPQ----LHGedsvmmnslpgvltqiMTNLVMNSVNhaFAETaqpEIDIHFYQKDQQIIIEYRDNGCGVAKELHQK 584
Cdd:NF033792 304 --PVIRRnpeiLYG----------------LGNLIENAVD--FARS---TVTVTASWDAESVTITIEDDGPGFPPDVLSR 360
|
250 260
....*....|....*....|....*
gi 1729404602 585 IFEPFFTTKRG----QGGSGLGLNL 605
Cdd:NF033792 361 IGEPYVTTRRGeerrPGGGGLGLGL 385
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
379-635 |
2.89e-10 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 63.54 E-value: 2.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 379 ALSLTRLQET----QTQLIESEKLAALGGLVAGVAHEVNTPLGiavtatsVIQETRESLLNAFNQQTLTSQQFAELmerm 454
Cdd:PRK13837 424 AIERRRLETErdalERRLEHARRLEAVGTLASGIAHNFNNILG-------AILGYAEMALNKLARHSRAARYIDEI---- 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 455 TQSTlmletnlNRAARLVrdfkqtavDQV------SEGRSQ-FHVKQVLDALMASLH-SETRKIPVTPQLHGEDSVMMNS 526
Cdd:PRK13837 493 ISAG-------ARARLII--------DQIlafgrkGERNTKpFDLSELVTEIAPLLRvSLPPGVELDFDQDQEPAVVEGN 557
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 527 lPGVLTQIMTNLVMNSVnHAFAETAQpeIDIHFYQKD---------------QQIIIEYRDNGCGVAKELHQKIFEPFFT 591
Cdd:PRK13837 558 -PAELQQVLMNLCSNAA-QAMDGAGR--VDISLSRAKlrapkvlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFFT 633
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1729404602 592 TKrgQGGSGLGLNLVFNLVKQkLHGQLAFSSEPGHGVHYVITLP 635
Cdd:PRK13837 634 TR--AGGTGLGLATVHGIVSA-HAGYIDVQSTVGRGTRFDVYLP 674
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
528-635 |
5.54e-10 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 61.87 E-value: 5.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 528 PGVLTQIMTNLVMNSVNHAfaetaQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTK----RGQGGSGLGL 603
Cdd:PRK09470 351 PNALASALENIVRNALRYS-----HTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDeardRESGGTGLGL 425
|
90 100 110
....*....|....*....|....*....|..
gi 1729404602 604 NLVFNLVKQKlHGQLAFSSEPGHGVHYVITLP 635
Cdd:PRK09470 426 AIVENAIQQH-RGWVKAEDSPLGGLRLTIWLP 456
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
535-638 |
7.48e-10 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 61.56 E-value: 7.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 535 MTNLVMNSVNHAFAETaqpEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFF----TTKRGQGGSGLGLnlvfNLV 610
Cdd:PRK11006 322 ISNLVYNAVNHTPEGT---HITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYrvdkARSRQTGGSGLGL----AIV 394
|
90 100 110
....*....|....*....|....*....|.
gi 1729404602 611 KQKLH---GQLAFSSEPGHGVHYVITLPQAL 638
Cdd:PRK11006 395 KHALShhdSRLEIESEVGKGTRFSFVLPERL 425
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
530-635 |
3.51e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 59.54 E-value: 3.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 530 VLTQIMTNLVMNSVNhAFAETAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKrgqgGSGLGLNLVfnL 609
Cdd:PRK11086 433 ELITILGNLIENALE-AVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTK----GSNRGVGLY--L 505
|
90 100
....*....|....*....|....*....
gi 1729404602 610 VKQ---KLHGQLAFSSEPGHGVHYVITLP 635
Cdd:PRK11086 506 VKQsveNLGGSIAVESEPGVGTQFFVQIP 534
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
384-635 |
6.18e-09 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 58.76 E-value: 6.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 384 RLQETQTQLIESEKLAALGGLVAGVAHEVNTPLGIAVTATSVIQETRESLLN----AFNQQTLTSQQfaELMERMTQS-- 457
Cdd:TIGR02938 259 RLSALQALMAEEERLEAIRETLSAAIHRLQGPMNLISAAISVLQRRGDDAGNpasaAMLQQALSAGR--EHMEALRQVip 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 458 ----TLMLETNLNRaarLVRDFKQTAVDQVsegrsqfhvkqvldaLMASLHSETRKIPVTPQLHGEDsvmmNSLPGVLTQ 533
Cdd:TIGR02938 337 qspqEIVVPVNLNQ---ILRDVITLSTPRL---------------LAAGIVVDWQPAATLPAILGRE----LQLRSLFKA 394
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 534 IMTNLVmNSVNHAfaETAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRGQG-GSGLGLNLVFNLVKQ 612
Cdd:TIGR02938 395 LVDNAI-EAMNIK--GWKRRELSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGGSRkHIGMGLSVAQEIVAD 471
|
250 260
....*....|....*....|...
gi 1729404602 613 KlHGQLAFSSEPGHGVHYVITLP 635
Cdd:TIGR02938 472 H-GGIIDLDDDYSEGCRIIVEFR 493
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-638 |
2.11e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 52.59 E-value: 2.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHAFAETaqpEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTK----RGQGGSGLGLNLV 606
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSD---TITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDiercRNTGGTGLGLAIV 77
|
90 100 110
....*....|....*....|....*....|..
gi 1729404602 607 FNLVKQKlHGQLAFSSEPGHGVHYVITLPQAL 638
Cdd:cd16952 78 KHVMSRH-DARLLIASELGKGSRFTCLFPSSR 108
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
226-635 |
2.68e-08 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 56.63 E-value: 2.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 226 TNRIANNVTTLYRTIKSEQERLEDFAQAASD-WLWETNCHGELIYSSEAMSTALAieedskPLMVSIAPLQSSTALMNCL 304
Cdd:TIGR01386 50 VRRFLRDPADLDEDIKRLQEKIDDLLVGHSDlALSILNPDGRLLFERAQGAALVP------AVAANDALLELDQADAKMT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 305 LKQQDFSNCEVELtLSDGTQAYLLFQGIARYADEQFL-GFRGTAINITSLKL---AQLSLEIMNQDLE-----QQVANRT 375
Cdd:TIGR01386 124 HYRSILRSVAALP-GGKGRKPVQITVALDINAHTHLLdALRKWLILIAVLLVlltALLGWWITRLGLEplrrlSAVAARI 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 376 QDLALSlTRLQETQT----QLIESEKLAALGGL----------VAGVAHEVNTPLGIAVTATSVI------QETRESLLN 435
Cdd:TIGR01386 203 SPESLD-QRLDPSRApaelRELAQSFNAMLGRLedafqrlsqfSADLAHELRTPLTNLLGQTQVAlsqprtGEEYREVLE 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 436 AfNQQTLtsqqfaELMERMTQSTLMLETNLNRAARLVRdfkqTAVDQVSEGRSQFHVKQVLdalmASLHSETRKIPVTPQ 515
Cdd:TIGR01386 282 S-NLEEL------ERLSRMVSDMLFLARADNGQLALER----VRLDLAAELAKVAEYFEPL----AEERGVRIRVEGEGL 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 516 LHGEdsvmmnslPGVLTQIMTNLVMNSVNHAFAETaqpEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFF----T 591
Cdd:TIGR01386 347 VRGD--------PQMFRRAISNLLSNALRHTPDGG---TITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYrvdpA 415
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1729404602 592 TKRGQGGSGLGLNLVFNLVkqKLHGQLAFSSEPGHGVHYVITLP 635
Cdd:TIGR01386 416 RSNSGEGTGLGLAIVRSIM--EAHGGRASAESPDGKTRFILRFP 457
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
519-635 |
4.39e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 55.79 E-value: 4.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 519 EDSVMMNSLPGVLTQImtnLVMNSVNHAFAETAQP-EIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRgqg 597
Cdd:COG2972 328 DEELLDLLIPKLILQP---LVENAIEHGIEPKEGGgTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGE--- 401
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1729404602 598 GSGLGLNLVFNLVKqKLHG---QLAFSSEPGHGVHYVITLP 635
Cdd:COG2972 402 GRGIGLRNVRERLK-LYYGeeyGLEIESEPGEGTTVTIRIP 441
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-635 |
1.26e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 50.23 E-value: 1.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHA-FAETAQPEIDIHFY-QKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKrgQGGSGLGLNLVFN 608
Cdd:cd16944 5 ISQVLTNILKNAAEAIeGRPSDVGEVRIRVEaDQDGRIVLIVCDNGKGFPREMRHRATEPYVTTR--PKGTGLGLAIVKK 82
|
90 100
....*....|....*....|....*...
gi 1729404602 609 LVKQklH-GQLAFSSEPGHGVHYVITLP 635
Cdd:cd16944 83 IMEE--HgGRISLSNREAGGACIRIILP 108
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-627 |
2.42e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 49.71 E-value: 2.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHAfAETAQPEIDIHFYQKDQQIIieyRDNGCGVAKELHQKIFEPFF-TTKRGQGGSGLGLNLVFNL 609
Cdd:cd16940 14 LFLLLRNLVDNAVRYS-PQGSRVEIKLSADDGAVIRV---EDNGPGIDEEELEALFERFYrSDGQNYGGSGLGLSIVKRI 89
|
90
....*....|....*....
gi 1729404602 610 VkqKLHG-QLAFSSEPGHG 627
Cdd:cd16940 90 V--ELHGgQIFLGNAQGGG 106
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
520-635 |
2.65e-07 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 53.97 E-value: 2.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 520 DSVMMNSLPGVLTQIMTNLVMNSVNhaFAETAQPEID---IHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRG- 595
Cdd:PRK09959 818 DHYLVKIDPQAFKQVLSNLLSNALK--FTTEGAVKITtslGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGr 895
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1729404602 596 -QGGSGLGLNLVFNLVKQkLHGQLAFSSEPGHGVHYVITLP 635
Cdd:PRK09959 896 qQTGSGLGLMICKELIKN-MQGDLSLESHPGIGTTFTITIP 935
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
527-635 |
3.36e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 48.96 E-value: 3.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 527 LPGVLTQImtnLVMNSVNHAFAETAQP-EIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRGQGGSGLGLNL 605
Cdd:cd16957 1 VPPFALQV---LVENAIRHAFPKRKENnEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEKGTGTALENLNR 77
|
90 100 110
....*....|....*....|....*....|...
gi 1729404602 606 VFNLvkqkLHGQ---LAFSSEPGHGVHYVITLP 635
Cdd:cd16957 78 RLIG----LFGSeacLHIESEVHGGTEVWFVIP 106
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-635 |
4.42e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 48.60 E-value: 4.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHAfaetaQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRGQGGSG--LGLNLVFN 608
Cdd:cd16950 1 LKRVLSNLVDNALRYG-----GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGtgLGLAIVQR 75
|
90 100
....*....|....*....|....*..
gi 1729404602 609 LVKQkLHGQLAFSSEPGHGVHYVITLP 635
Cdd:cd16950 76 ISDA-HGGSLTLANRAGGGLCARIELP 101
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
522-635 |
1.39e-06 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 51.51 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 522 VMMNSLPGVLTQIMTNLVMNSVNhaFAETAQpeIDIHFYQKDQQIIIEYRDNGCGV-AKELHQkIFEPFFT----TKRGQ 596
Cdd:PRK10841 554 VALNGDPMRLQQVISNLLSNAIK--FTDTGC--IVLHVRVDGDYLSFRVRDTGVGIpAKEVVR-LFDPFFQvgtgVQRNF 628
|
90 100 110
....*....|....*....|....*....|....*....
gi 1729404602 597 GGSGLGLNLVFNLVKQkLHGQLAFSSEPGHGVHYVITLP 635
Cdd:PRK10841 629 QGTGLGLAICEKLINM-MDGDISVDSEPGMGSQFTIRIP 666
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
409-627 |
1.40e-06 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 51.19 E-value: 1.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 409 AHEVNTPLGIAVTATSVIQETRESllnafnqqtltsqqfaelmERMTQSTLM-LETNLNRAARLVRDF----KQTAVDQV 483
Cdd:PRK10337 245 AHELRSPLAALKVQTEVAQLSDDD-------------------PQARKKALLqLHAGIDRATRLVDQLltlsRLDSLDNL 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 484 sEGRSQFHVKQVL-DALMASLH-SETRKIPVTPQLHGEDsVMMNSLPGVLTQIMTNLVMNSVNHAFAETAqpeIDIHFYQ 561
Cdd:PRK10337 306 -QDVAEIPLEDLLqSAVMDIYHtAQQAGIDVRLTLNAHP-VIRTGQPLLLSLLVRNLLDNAIRYSPQGSV---VDVTLNA 380
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1729404602 562 KDQQIiieyRDNGCGVAKELHQKIFEPFFTTKrGQ--GGSGLGLNLVFNLVkqKLHG-QLAFSSEPGHG 627
Cdd:PRK10337 381 RNFTV----RDNGPGVTPEALARIGERFYRPP-GQeaTGSGLGLSIVRRIA--KLHGmNVSFGNAPEGG 442
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
358-645 |
2.07e-06 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 50.76 E-value: 2.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 358 LSLEIMNQDL-EQQVANRTQ-DLALSLTRLQETQTQ-------LIESEKLaalggLVAGVAHEVNTPLgiavtatsVIQE 428
Cdd:PRK10604 165 LKLEAAAQRLgDGHLAERIHfDEGSSLERLGVAFNQmadninaLIASKKQ-----LIDGIAHELRTPL--------VRLR 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 429 TRESLLNAfnqqtLTSQQFAELMERMTQSTLMLETNLNRAaRLVRDfkqtavdQVSEGRSQFHVKQVLDALMA---SLHS 505
Cdd:PRK10604 232 YRLEMSDN-----LSAAESQALNRDIGQLEALIEELLTYA-RLDRP-------QNELHLSEPDLPAWLSTHLAdiqAVTP 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 506 ETR---KIPVTPQLHGEDsvmmnslPGVLTQIMTNLVMNSVNHAfaetaQPEIDIHFYQKDQQIIIEYRDNGCGVAKELH 582
Cdd:PRK10604 299 EKTvrlDTPHQGDYGALD-------MRLMERVLDNLLNNALRYA-----HSRVRVSLLLDGNQACLIVEDDGPGIPPEER 366
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1729404602 583 QKIFEPFF----TTKRGQGGSGLGLNLVFNLVkQKLHGQLAFSSEPGHGVHYVITLPQALSMPQVAD 645
Cdd:PRK10604 367 ERVFEPFVrldpSRDRATGGCGLGLAIVHSIA-LAMGGSVNCDESELGGARFSFSWPVWHNLPQFTS 432
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
531-639 |
2.20e-06 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 51.00 E-value: 2.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNhaFaeTAQPEIDI---HFYQKDQQIIIEY--RDNGCGVAKELHQKIFEPFfttkrGQ--------- 596
Cdd:PRK11107 409 LQQIITNLVGNAIK--F--TESGNIDIlveLRALSNTKVQLEVqiRDTGIGISERQQSQLFQAF-----RQadasisrrh 479
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1729404602 597 GGSGLGLNLVFNLVKQkLHGQLAFSSEPGHGVHYVITLPQALS 639
Cdd:PRK11107 480 GGTGLGLVITQKLVNE-MGGDISFHSQPNRGSTFWFHLPLDLN 521
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
511-635 |
2.89e-06 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 47.96 E-value: 2.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 511 PVTPQLHGEDSVMMNSlpgVLTQI---MTNLVMNSVNHA--FAETAQ-----PE--IDIHFYQKDQQIIIEYRDNGCGVA 578
Cdd:cd16916 19 QVELVVEGEDTELDKS---VLEKLadpLTHLLRNAVDHGieAPEERLaagkpPEgtITLRAEHQGNQVVIEVSDDGRGID 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 579 K------------------------ELHQKIFEPFFTTKRGQG---GSGLGLNLVFNLVkQKLHGQLAFSSEPGHGVHYV 631
Cdd:cd16916 96 RekirekaierglitadeaatlsddEVLNLIFAPGFSTAEQVTdvsGRGVGMDVVKRSI-ESLGGTIEVESEPGQGTTFT 174
|
....
gi 1729404602 632 ITLP 635
Cdd:cd16916 175 IRLP 178
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
530-634 |
4.33e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 46.35 E-value: 4.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 530 VLTQIMTNLVMNSVNHAfaeTAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTK----RGQGGSGLGLNL 605
Cdd:cd16947 20 ALQRILKNLISNAIKYG---SDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEdsrnSAKQGNGLGLTI 96
|
90 100
....*....|....*....|....*....
gi 1729404602 606 VFNLVkQKLHGQLAFSSEPGHGVHYVITL 634
Cdd:cd16947 97 TKRLA-ESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-635 |
5.69e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 45.50 E-value: 5.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHAfaetaQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFF----TTKRGQGGSGLGLNLV 606
Cdd:cd16939 1 MARALDNLLRNALRYA-----HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpSRDRATGGFGLGLAIV 75
|
90 100
....*....|....*....|....*....
gi 1729404602 607 fNLVKQKLHGQLAFSSEPGHGVHYVITLP 635
Cdd:cd16939 76 -HRVALWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
566-635 |
7.30e-06 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 45.18 E-value: 7.30e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1729404602 566 IIIEYRDNGCGVAKELHQKIFEPFF----TTKRGQGGSGLGLNLVFNLVkqKLH-GQLAFSSEPGHGVHYVITLP 635
Cdd:cd16925 38 FLLTVSDSGPGIPPNLREEIFERFRqgdgSSTRAHGGTGLGLSIVKEFV--ELHgGTVTVSDAPGGGALFQVELP 110
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
382-635 |
1.07e-05 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 48.02 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 382 LTRLQETQTQLIEseKLAALGGLVAGVAHEVNTPLgiavTATSVIQETRESLLNAFN---QQTLTSQQF------AELME 452
Cdd:PRK09303 134 LFVLRQENETLLE--QLKFKDRVLAMLAHDLRTPL----TAASLALETLELGQIDEDtelKPALIEQLQdqarrqLEEIE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 453 RMtqSTLMLETNLNRAARLvrDFKQTAVDQvsEGRSQFHVKQVLDALMA-SLHSETrKIPVT-PQLHGEDSVMMnslpgv 530
Cdd:PRK09303 208 RL--ITDLLEVGRTRWEAL--RFNPQKLDL--GSLCQEVILELEKRWLAkSLEIQT-DIPSDlPSVYADQERIR------ 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 ltQIMTNLVMNSVNHAfAETAQPEIDIhFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRGQG--GSGLGLNLVFN 608
Cdd:PRK09303 275 --QVLLNLLDNAIKYT-PEGGTITLSM-LHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGteGYGIGLSVCRR 350
|
250 260
....*....|....*....|....*...
gi 1729404602 609 LVkqKLH-GQLAFSSEPGHGVHYVITLP 635
Cdd:PRK09303 351 IV--RVHyGQIWVDSEPGQGSCFHFTLP 376
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
356-635 |
1.30e-05 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 47.77 E-value: 1.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 356 AQLSLEIMNQDLEQQ-----------VANRTQDLALSLTRLQE----------------TQTQLIESEKLAAlGGLVAGV 408
Cdd:PRK11073 59 FSLNIELMRESLQAGqgftdnevtlvIDGRSHILSLTAQRLPEgmillemapmdnqrrlSQEQLQHAQQVAA-RDLVRGL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 409 AHEVNTPLGiavtatsviqetreSLLNAfnqqtltsqqfAELMERMTQSTLMLETN---LNRAARLvrdfkQTAVDQV-- 483
Cdd:PRK11073 138 AHEIKNPLG--------------GLRGA-----------AQLLSKALPDPALTEYTkviIEQADRL-----RNLVDRLlg 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 484 --SEGRSQFHvkqvldalmaSLHSETRKIPVTPQLHGEDSVMMN-----SLPGV------LTQIMTNLVMNSVnHAFAE- 549
Cdd:PRK11073 188 pqRPGTHVTE----------SIHKVAERVVQLVSLELPDNVRLIrdydpSLPELahdpdqIEQVLLNIVRNAL-QALGPe 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 550 ---------TAQpEIDIH--FYQKDQQIIIEyrDNGCGVAKELHQKIFEPFFTTKrgQGGSGLGLNLVFNLVKQKlHGQL 618
Cdd:PRK11073 257 ggtitlrtrTAF-QLTLHgeRYRLAARIDIE--DNGPGIPPHLQDTLFYPMVSGR--EGGTGLGLSIARNLIDQH-SGKI 330
|
330
....*....|....*..
gi 1729404602 619 AFSSEPGHgVHYVITLP 635
Cdd:PRK11073 331 EFTSWPGH-TEFSVYLP 346
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-635 |
1.80e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 43.91 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHAFAETAqpeIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFF--TTKRGQGGSGLGLNLVFN 608
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTR---IYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgDNSRNTEGAGLGLSIAKA 77
|
90 100
....*....|....*....|....*..
gi 1729404602 609 LVkqKLHGQLAFSSEPGHGVHYVITLP 635
Cdd:cd16923 78 II--ELHGGSASAEYDDNHDLFKVRLP 102
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
368-636 |
2.94e-05 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 47.34 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 368 EQQ--VANRTQDLALSLTRLQETQTQliESEKLAA-----LGGLVAGVAHEVNTPLgiavtaTSVIQETRESLLNAFNQQ 440
Cdd:PRK10490 626 EQQrlLETFTLLIANALERLTLTASE--EQARLASereqlRNALLAALSHDLRTPL------TVLFGQAEILTLDLASEG 697
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 441 TLTSQQfAELMERMTQSTLMLETNLNRAARLvrdfkqtavdQvSEGrsqFHVK---QVLDALMAS-LHSetrkipVTPQL 516
Cdd:PRK10490 698 SPHARQ-ASEIRQQVLNTTRLVNNLLDMARI----------Q-SGG---FNLRkewLTLEEVVGSaLQM------LEPGL 756
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 517 HG--------EDSVMMNSLPGVLTQIMTNLVMNSVNHAfaeTAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEP 588
Cdd:PRK10490 757 SGhpinlslpEPLTLIHVDGPLFERVLINLLENAVKYA---GAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDK 833
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1729404602 589 FfttKRGQG-----GSGLGLNLVFNLVkqKLH-GQLAFSSEPGHGVHYVITLPQ 636
Cdd:PRK10490 834 F---ARGNKesaipGVGLGLAICRAIV--EVHgGTIWAENRPEGGACFRVTLPL 882
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
369-639 |
3.36e-05 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 46.50 E-value: 3.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 369 QQVANRTQDLALSLTRLQETqtqlIESEKLAAlgglvAGVAHEVNTPL-GIAV-----TATSVIQETreSLLNAFNQQTL 442
Cdd:PRK10755 114 LEIEAVTSALNQLVSRLTST----LDQERLFT-----ADVAHELRTPLaGIRLhlellEKQHHIDVA--PLIARLDQMMH 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 443 TSQQFaelmermtqstLMLetnlnraARLVRDFKQTAVDQVSegrsqfHVKQVLDALMASLHS--ETRKIPVTPQLHGED 520
Cdd:PRK10755 183 TVEQL-----------LQL-------ARAGQSFSSGHYQTVK------LLEDVILPSQDELSEmlEQRQQTLLLPESAAD 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 521 SVMmnslPG--VLTQIMT-NLVMNSVNHAFAETAqpeIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRGQG 597
Cdd:PRK10755 239 ITV----QGdaTLLRLLLrNLVENAHRYSPEGST---ITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSRYG 311
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1729404602 598 GSGLGLNLVFNLVkQKLHGQLAFSSEP-GHGVHYVITLPQALS 639
Cdd:PRK10755 312 GIGLGLSIVSRIT-QLHHGQFFLQNRQeRSGTRAWVWLPKAQN 353
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
455-636 |
3.59e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 46.75 E-value: 3.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 455 TQSTLMLETNLNRAARLVRDFKQTAVDQVSEGRSQFHVKQVLDALMASLHSETR---KIPVTP--QLH----GEDSVMmn 525
Cdd:PRK15053 355 TLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFADRQVAGLLFGKVQRARElglKMVIVPgsQLSqlppGLDSTE-- 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 526 slpgvLTQIMTNLVMNSVNhAFAETAQPEIDIHFYQKDQ--QIIIEYRDNGCGVAKELHQKIFEPFFTTKRGQGGS-GLG 602
Cdd:PRK15053 433 -----FAAIVGNLLDNAFE-ASLRSDEGNKIVELFLSDEgdDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGEhGIG 506
|
170 180 190
....*....|....*....|....*....|....
gi 1729404602 603 LNLVFNLVkQKLHGQLAFSSEPGHGVHYVITLPQ 636
Cdd:PRK15053 507 LYLIASYV-TRCGGVITLEDNDPCGTLFSIFIPK 539
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
439-635 |
3.87e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 45.76 E-value: 3.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 439 QQTLTS--QQFAELMERMTQSTLMLETNLNRAARLVRDfkqtAVDQV--------SEGRSQFHVKQVLDALMASLHSETr 508
Cdd:COG4585 66 GQSLSAikLQLEAARRLLDADPEAAREELEEIRELARE----ALAELrrlvrglrPPALDDLGLAAALEELAERLLRAA- 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 509 KIPVTPQLHGEDSVMMNSLPGVLTQIMTNLVMNSVNHAFAEtaqpEIDIHFYQKDQQIIIEYRDNGCGvakelhqkiFEP 588
Cdd:COG4585 141 GIRVELDVDGDPDRLPPEVELALYRIVQEALTNALKHAGAT----RVTVTLEVDDGELTLTVRDDGVG---------FDP 207
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1729404602 589 ffttkRGQGGSGLGLNLVFNLVKQkLHGQLAFSSEPGHGVHYVITLP 635
Cdd:COG4585 208 -----EAAPGGGLGLRGMRERAEA-LGGTLTIGSAPGGGTRVRATLP 248
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
531-645 |
3.91e-05 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 46.86 E-value: 3.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNhaFaeTAQPEIDIHF-YQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRGQG-----GSGLGLN 604
Cdd:PRK11091 399 LRQILWNLISNAVK--F--TQQGGVTVRVrYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGgkpatGTGIGLA 474
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1729404602 605 LVFNLVkQKLHGQLAFSSEPGHGVHYVITLPQALSMPQVAD 645
Cdd:PRK11091 475 VSKRLA-QAMGGDITVTSEEGKGSCFTLTIHAPAVAEEVED 514
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
538-610 |
4.32e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 43.36 E-value: 4.32e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1729404602 538 LVMNSVNHAFAETAQPEIDIHFYQKDQQIIIEYRDNGCGVAKElhqKIFEPFFTTKRGqggsGLGLNLVFNLV 610
Cdd:COG2172 42 AVTNAVRHAYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPE---DLPDPYSTLAEG----GRGLFLIRRLM 107
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
528-634 |
7.62e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 43.00 E-value: 7.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 528 PGVLTQIMTNLVMNSVNHAFAetaQPEIDIHFYQKDQQIIIEyrDNGCGVAKELHQKIFEpffttkRGQ------GGSGL 601
Cdd:cd16954 35 RNDLMELLGNLLDNACKWCLE---FVEVTARQTDGGLHLIVD--DDGPGVPESQRSKIFQ------RGQrldeqrPGQGL 103
|
90 100 110
....*....|....*....|....*....|...
gi 1729404602 602 GLNLVFNLVKQkLHGQLAFSSEPGHGVHYVITL 634
Cdd:cd16954 104 GLAIAKEIVEQ-YGGELSLSDSPLGGARFEVVF 135
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
493-636 |
1.08e-04 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 45.35 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 493 KQVLDALMASLHSETRKIPVTPQLHGEDSVMMNSLPGVLTQIMTNLVMNSVNHAFAEtaqpEIDIHFYQKDQQIIIEYRD 572
Cdd:PRK11644 373 EQAIRSLMREMELEDRGIVSHLDWRIDESALSETQRVTLFRVCQEGLNNIVKHADAS----AVTLQGWQQDERLMLVIED 448
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1729404602 573 NGCGVakelhqkifepffttKRGQGGSGLGLNLVFNLVkQKLHGQLAFSSEpgHGVHYVITLPQ 636
Cdd:PRK11644 449 DGSGL---------------PPGSGQQGFGLRGMRERV-TALGGTLTISCT--HGTRLSVSLPQ 494
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-618 |
1.55e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 41.29 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVNHAFAETAqpeIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKRGQ---GGSGLGLNLVF 607
Cdd:cd16975 5 LSRALINIISNACQYAPEGGT---VSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRrsgGHYGMGLYIAK 81
|
90
....*....|.
gi 1729404602 608 NLVkQKLHGQL 618
Cdd:cd16975 82 NLV-EKHGGSL 91
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
406-637 |
1.72e-04 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 44.38 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 406 AGVAHEVNTPLgiavtaTSVIQETRESLLNAFNQQTLTSQQFAELMErmtqstlmletnLNRAARLVRD--FKQTAVDQv 483
Cdd:PRK09835 267 ADIAHEIRTPI------TNLITQTEIALSQSRSQKELEDVLYSNLEE------------LTRMAKMVSDmlFLAQADNN- 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 484 segrsQFHVKQVldalMASLHSETRKI-----------PVTPQLHGeDSVMMNSLPGVLTQIMTNLVMNSVNHAFAETAq 552
Cdd:PRK09835 328 -----QLIPEKK----MLDLADEVGKVfdffeawaeerGVELRFVG-DPCQVAGDPLMLRRAISNLLSNALRYTPAGEA- 396
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 553 peIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFF----TTKRGQGGSGLGLNLVFNLVKQKlHGQLAFSSEPgHGV 628
Cdd:PRK09835 397 --ITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYrvdpSRQRKGEGSGIGLAIVKSIVVAH-KGTVAVTSDA-RGT 472
|
....*....
gi 1729404602 629 HYVITLPQA 637
Cdd:PRK09835 473 RFVISLPRL 481
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
238-380 |
2.74e-04 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 43.09 E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 238 RTIKSEQERLEDFAQAASDWLWETNCHGELIYSSEAMSTALAIEED-----SKPLMVSIAPLQSSTALMNCLLKQQDFSN 312
Cdd:COG2202 4 EALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEellgkTLRDLLPPEDDDEFLELLRAALAGGGVWR 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1729404602 313 CEVELTLSDGTQAYLLFQGIA-RYADEQFLGFRGTAINITSLKLAQLSLEIMNQDLEQQVANRTQDLAL 380
Cdd:COG2202 84 GELRNRRKDGSLFWVELSISPvRDEDGEITGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFV 152
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
533-635 |
2.79e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 40.23 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 533 QIMTNLVMNSVNHAFAETAqpeiDIHFYQKDQQIIIEYRDNGCGvakelhqkifepfFTTKRGQGGSGLGLN-----Lvf 607
Cdd:cd16917 3 RIVQEALTNALKHAGASRV----RVTLSYTADELTLTVVDDGVG-------------FDGPAPPGGGGFGLLgmrerA-- 63
|
90 100
....*....|....*....|....*...
gi 1729404602 608 nlvkQKLHGQLAFSSEPGHGVHYVITLP 635
Cdd:cd16917 64 ----ELLGGTLTIGSRPGGGTRVTARLP 87
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
534-635 |
6.00e-04 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 42.59 E-value: 6.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 534 IMTNLVMNSVNHAfaetaQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFT--TKRGQGGSGLGLNLVFNLVK 611
Cdd:PRK09467 335 ALANLVVNAARYG-----NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRgdSARGSSGTGLGLAIVKRIVD 409
|
90 100
....*....|....*....|....
gi 1729404602 612 QKlHGQLAFSSEPGHGVHYVITLP 635
Cdd:PRK09467 410 QH-NGKVELGNSEEGGLSARAWLP 432
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
425-639 |
2.15e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 40.94 E-value: 2.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 425 VIQETR-ESLLNAFNQQTLTS-QQFAELMERMT---QSTLM------LETNLNRAARLVRDfkqTAVDQvseGRS-QFHV 492
Cdd:COG0643 190 VITRARlEQLAEELEDESLRElEEALEQLSRLTrelQDGVMrlrmvpISTVFNRFPRMVRD---LAREL---GKEvELVI 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 493 --------KQVLDALMASLhsetrkipvtpqLHgedsvmmnslpgvltqimtnLVMNSVNHAfAETAQ-------PE--- 554
Cdd:COG0643 264 egeeteldRTVLERLGDPL------------VH--------------------LVRNAVDHG-IETPEerlaagkPEtgt 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 555 IDIHFYQKDQQIIIEYRDNGCG----------VAK--------------ELHQKIFEPFFTTK--------RGqggsgLG 602
Cdd:COG0643 311 ITLSAYHEGGRVVIEVSDDGRGldlekirakaIEKglitaeeaaalsdeELLELIFAPGFSTAeevtdlsgRG-----VG 385
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1729404602 603 LNlVfnlVK---QKLHGQLAFSSEPGHGVHYVITLPQALS 639
Cdd:COG0643 386 MD-V---VKtniEALGGTIEIESEPGKGTTFTLRLPLTLA 421
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
528-616 |
3.39e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 37.44 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 528 PGVLTQIMTNLVMNSVnhAFAeTAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKR---GQGGSGLGLN 604
Cdd:cd16945 2 PFLLRQAINNLLDNAI--DFS-PEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRphsGQKSTGLGLA 78
|
90
....*....|..
gi 1729404602 605 LVFNLVkqKLHG 616
Cdd:cd16945 79 FVQEVA--QLHG 88
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
238-360 |
3.62e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 39.62 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 238 RTIKSEQERLEDFAQAASDWLWETNCHGELIYSSEAMSTALAIEED---SKPLMVSIAPLQSSTALMN---CLLKQQDFS 311
Cdd:COG2202 130 EALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEellGKSLLDLLHPEDRERLLELlrrLLEGGRESY 209
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1729404602 312 NCEVELTLSDGTQAYLLFQGIARYADEQFLGFRGTAINITSLKLAQLSL 360
Cdd:COG2202 210 ELELRLKDGDGRWVWVEASAVPLRDGGEVIGVLGIVRDITERKRAEEAL 258
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
531-627 |
5.40e-03 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 37.52 E-value: 5.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNL---VMNSVNHAFAETAQPEIDIHFYQKDQQIIIEYRDNGCGVakELHQKIFEPFFTTKRGQGGSGLGLNLVF 607
Cdd:cd16942 36 LTEIKTVVseaVTNAIIHGYNNDPNGIVSISVIIEDGVVHLTVRDEGVGI--PDIEEARQPLFTTKPELERSGMGFTIME 113
|
90 100
....*....|....*....|
gi 1729404602 608 NLVKqklhgQLAFSSEPGHG 627
Cdd:cd16942 114 NFMD-----EVIVESEVNKG 128
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
561-645 |
5.41e-03 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 39.92 E-value: 5.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 561 QKDQQIIIEYRDNGCGV-AKELHQKIFePFFT---TKRGQGGSGLGLNLVFNLVKqKLHGQLAFSSEPGHGVHYVITLPQ 636
Cdd:PRK10618 595 SSPDRLTIRILDTGAGVsIKELDNLHF-PFLNqtqGDRYGKASGLTFFLCNQLCR-KLGGHLTIKSREGLGTRYSIHLKM 672
|
....*....
gi 1729404602 637 ALSMPQVAD 645
Cdd:PRK10618 673 LAADPEVEE 681
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
531-635 |
8.70e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 36.40 E-value: 8.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1729404602 531 LTQIMTNLVMNSVnhAFAETAQPEIDIHFYQKDQQIIIEYRDNGCGVAKELHQKIFEPFFTTKR-----GQgGSGLGLNL 605
Cdd:cd16953 1 LGQVLRNLIGNAI--SFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPaneafGQ-HSGLGLSI 77
|
90 100 110
....*....|....*....|....*....|....*
gi 1729404602 606 VFNLVkqKLHGQLAFS---SEPGH--GVHYVITLP 635
Cdd:cd16953 78 SRQII--EAHGGISVAenhNQPGQviGARFTVQLP 110
|
|
| |
