|
Name |
Accession |
Description |
Interval |
E-value |
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
1-393 |
1.07e-100 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 304.15 E-value: 1.07e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 1 MSSCVAA-SEAVAPAKPAWRAVYSLGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATK 79
Cdd:PRK10213 1 MSEFIAEnRGADAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 80 SIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVA 159
Cdd:PRK10213 81 ATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 160 APLGSYLGSLIGWRNVFVLCILPSMLALLWQLWVLPSMKPESSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLR 239
Cdd:PRK10213 161 APLGSFLGELIGWRNVFNAAAVMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 240 PFLETVGQASVETISLILLGFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFG 319
Cdd:PRK10213 241 PVYMNLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPLVLAVSALVLTLWGSDKIVATGVAIIWGLTFA 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1730589346 320 LVPVGWSTWLATTVPDEAESAGGLLVASIQLAISAGAAGGGAVFDLNGASGVFAGSGLLLVTAMVIVFMGVKVK 393
Cdd:PRK10213 321 LVPVGWSTWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMK 394
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
21-387 |
2.46e-59 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 197.00 E-value: 2.46e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 21 VYSLGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLL 100
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 101 VAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCI 180
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 181 LPSMLALLWQLWVLPSMKPESSGSL---STLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLIL 257
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLgllSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 258 LGFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVGWSTWLATTVPDEA 337
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1730589346 338 ESAGGLLVASIQLAISAGAAGGGAVFDLNGASGVFAGSGLLLVTAMVIVF 387
Cdd:cd17324 321 GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
15-318 |
1.23e-41 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 150.81 E-value: 1.23e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 15 KPAWRAVYSLGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQ 94
Cdd:PRK03545 5 KVAWLRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 95 IISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRN 174
Cdd:PRK03545 85 IASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 175 VFVLCILPSMLALLWQLWVLPSMKPESSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETIS 254
Cdd:PRK03545 165 TFLAIGGGALITLLLLIKLLPLLPSEHSGSLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSENFAT 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1730589346 255 LILLGFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAF 318
Cdd:PRK03545 245 LLLLLFGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAI 308
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-349 |
2.06e-34 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 130.48 E-value: 2.06e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 12 APAKPAWRAVYSLGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFS 91
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 92 VLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIG 171
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 172 WRNVFVLCILPSMLALLWQLWVLPSMKPESSGSL-STLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASV 250
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAARARLrGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 251 ETISLILLGFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVGWSTWLA 330
Cdd:COG2814 243 SAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
330
....*....|....*....
gi 1730589346 331 TTVPDEAESAGGLLVASIQ 349
Cdd:COG2814 323 ELAPPEARGRASGLYNSAF 341
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
19-300 |
2.32e-24 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 103.25 E-value: 2.32e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 19 RAVYSLGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISS 98
Cdd:PRK10091 3 KVILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 99 LLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVL 178
Cdd:PRK10091 83 AMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 179 CILPSMLALLWQLWVLPSMKPESSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILL 258
Cdd:PRK10091 163 IAVFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMM 242
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1730589346 259 GFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAF 300
Cdd:PRK10091 243 LVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLMLFF 284
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-390 |
4.79e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 99.19 E-value: 4.79e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 24 LGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAF 103
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 104 APNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPS 183
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 184 MLALLWQLWVLP-------SMKPESSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLI 256
Cdd:cd17325 161 LLALVLALLLLPeprpppnKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 257 LLGFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVGWSTWLATTVPDE 336
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1730589346 337 A-ESAGGLLVASIQLAISAGAAGGGAVFDLNGASGVFAGSGLLLVTAMVIVFMGV 390
Cdd:cd17325 321 GrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-391 |
6.45e-20 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 89.93 E-value: 6.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 12 APAKPAWRAVYSLGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFS 91
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 92 VLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIG 171
Cdd:COG2271 83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 172 WRNVFVLCILPSMLALLWQLWVLpsmkpessgslstlfrvlrrpgmiggMLATILIFSGHFAFFTYLRPFLETVGQASVE 251
Cdd:COG2271 163 WRAAFLILGLPGLLLALLRFWLL--------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 252 TISLILLGFGIANFVGTSVAGHL---LARNLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVGWSTW 328
Cdd:COG2271 217 QAGLLLSLPFLAGIVGSLLGGWLsdrLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALA 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1730589346 329 LATTVPDEAESAGGLLVASIQLAISAGAAGGGAVFDLNGASGVFAGSGLLLVTAMVIVFMGVK 391
Cdd:COG2271 297 AELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
15-395 |
6.56e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 90.33 E-value: 6.56e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 15 KPAWRAVYSLGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQ 94
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 95 IISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRN 174
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 175 VFVLCILPSMLALLWQLWVL----PSMKPESSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASV 250
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLrdppAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 251 ETISLILLGFGIANFVGTSVAGHLLAR-NLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVGWSTWL 329
Cdd:COG2223 241 ATAGLLAALFALLGALGRPLGGWLSDRiGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1730589346 330 ATTVP-DEAESAGGLLVASIQLAISAGAAGGGAVFDLNG--ASGVFAGSGLLLVTAMVIVFMGVKVKAE 395
Cdd:COG2223 321 PDIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsyTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
24-387 |
1.01e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.79 E-value: 1.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 24 LGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAF 103
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 104 APNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGS--LIGWRNVFVLCIL 181
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 182 PSMLALLWQLWVLPSMKPESSG---------SLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVET 252
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAkneeassksVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 253 ISLILLGFGIANFVGTSVAGHLLARNL-RLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVGWSTWLAT 331
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIgRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1730589346 332 TVPDEAESAGGLLVASIQLAISAGAAGGGAVFDL--NGASGVFAGSGLLLVTAMVIVF 387
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAatFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
41-388 |
1.59e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 89.17 E-value: 1.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 41 LLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIA 120
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 121 IGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGsLIGWRNVFVLCILPSMLALLWQLWVLPSMKPE 200
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPEPKEK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 201 ----SSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHLLA 276
Cdd:cd17474 180 akssSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 277 -RNLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVGWSTWLATTVPDEAES-AGGLLVASIQLAISA 354
Cdd:cd17474 260 kRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGtASSLYNFVRFLGQAV 339
|
330 340 350
....*....|....*....|....*....|....
gi 1730589346 355 GAAGGGAVFDLNGASGVFAGSGLLLVTAMVIVFM 388
Cdd:cd17474 340 GPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
45-388 |
3.70e-18 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 85.32 E-value: 3.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 45 MAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGF 124
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 125 WAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQLWVLPSMKPE---- 200
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEekrk 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 201 --SSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHLLARN 278
Cdd:cd17320 185 plLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRF 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 279 ---LRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGL-VPVGWSTWLATTVPDEAESAGGLLVASIQLAISA 354
Cdd:cd17320 265 gprRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFgLIFPNATSLALEPFPHVAGTASALLGFLQFLIGA 344
|
330 340 350
....*....|....*....|....*....|....
gi 1730589346 355 GAAGGGAVFDLNGASGVFAGSGLLLVTAMVIVFM 388
Cdd:cd17320 345 LAGALVGLLPNGTALPMGLLILVLGLLALLLLIL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
36-336 |
6.51e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 84.01 E-value: 6.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 36 FLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRL 115
Cdd:pfam07690 14 LLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 116 LLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQLWVLP 195
Cdd:pfam07690 94 LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 196 -------SMKPESSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLrPFLETVGQASVETISLILLGFGIANFVGT 268
Cdd:pfam07690 174 ppeskrpKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL-PLYQEVLGLSALLAGLLLGLGGLLGAIGR 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1730589346 269 SVAGHLLAR---NLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVGWSTWLATTVPDE 336
Cdd:pfam07690 253 LLLGRLSDRlgrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKE 323
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
24-386 |
1.62e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 83.03 E-value: 1.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 24 LGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAF 103
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 104 APNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPS 183
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 184 MLALL--WQLWVLPSMKPESSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASvetISLILLGFG 261
Cdd:cd17489 161 LLALLlvFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN---AGLFFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 262 IANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVGWSTW-LATTVPDEAESA 340
Cdd:cd17489 238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALaVDLVPPHRRGAA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1730589346 341 GGLLVASIQLAISAGAAGGGAVFDLNGASGVFAGSGLLLVTAMVIV 386
Cdd:cd17489 318 NGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
41-321 |
1.47e-14 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 74.65 E-value: 1.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 41 LLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIA 120
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 121 IGGFWAMSTATTMRLVPADKVPKALAVIFSSVSI----ATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQLWV--- 193
Cdd:cd17371 101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVgwllATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVkep 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 194 ---LPSMKPESSGSLSTLFRVLRRPGMIGGMLATILIFS----GHFAFFTYLRPFLETVGQASVETISLILLGFGIANFV 266
Cdd:cd17371 181 pqwQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATgalgGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFL 260
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1730589346 267 GTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAmLDGLLVALWGFAFGLV 321
Cdd:cd17371 261 GYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLS-PTLILILGFPLGFFAS 314
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
24-353 |
1.05e-13 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 71.84 E-value: 1.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 24 LGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAF 103
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 104 APNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPS 183
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 184 MLALLwqlwVLPSMKpessgslstlFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIA 263
Cdd:cd17503 161 ILALL----LAPLLD----------LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 264 NFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAM---LDGLLVALWGFAFGLVPVGWSTWLATTVPDE-AES 339
Cdd:cd17503 227 SAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTslwLIILPLFIRGLGMGLVFMPLNTLALNSLPPEqIGD 306
|
330
....*....|....
gi 1730589346 340 AGGLLVASIQLAIS 353
Cdd:cd17503 307 ATALFNTIRQLGGS 320
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
48-318 |
2.50e-13 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 70.32 E-value: 2.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 48 SLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAM 127
Cdd:cd17316 30 SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 128 STATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLI----GWRNVFVLCILPSMLALLWqlwvlpsmkpessg 203
Cdd:cd17316 110 ASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRILFLIGALPALLALLL-------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 204 slstlfrvlrRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHLLARNLRLTL 283
Cdd:cd17316 176 ----------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKT 245
|
250 260 270
....*....|....*....|....*....|....*
gi 1730589346 284 ALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAF 318
Cdd:cd17316 246 LVIGLILSGILALPLFYLLSGSPTLLLLLLFILSF 280
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
45-388 |
1.75e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 67.97 E-value: 1.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 45 MAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGF 124
Cdd:cd17321 22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 125 WAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQlwvlpsmkpessgs 204
Cdd:cd17321 102 MPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA-------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 205 lstlfrvlrrPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHLLARN-----L 279
Cdd:cd17321 168 ----------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFgprlvL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 280 RLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVgWSTWLATTVPDEAESAGGLLVASIQLAISAGAAGG 359
Cdd:cd17321 238 VAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPL-TNAALSSVPKEKAGAASGILNTARQLGGALGVALL 316
|
330 340
....*....|....*....|....*....
gi 1730589346 360 GAVFDLNGASGVFAGSGLLLVTAMVIVFM 388
Cdd:cd17321 317 GALLTAGLSANLGDSGVAALLSAAAAAFA 345
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-305 |
7.65e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 65.60 E-value: 7.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 7 ASEAVAPAKPAWRAVYSLGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWV 86
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 87 LMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYL 166
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 167 GSLIGWRNVFVLCILPSMLALLWQLWVlpsmkPESSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVG 246
Cdd:COG0477 162 VAALGWRWIFLINAPLGLLALVLRLRL-----PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAG 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1730589346 247 QASVETISLILLGFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAM 305
Cdd:COG0477 237 AALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
41-348 |
8.45e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 66.05 E-value: 8.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 41 LLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIA 120
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 121 IGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQLWVLPSmkpe 200
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 201 ssgslstlfrvlrrpgMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHL---LAR 277
Cdd:cd17319 181 ----------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLsdrLLR 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1730589346 278 NLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVGWSTWLATTVPDEAESAGGLLVASI 348
Cdd:cd17319 245 GARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSG 315
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
45-336 |
8.86e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.06 E-value: 8.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 45 MAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGF 124
Cdd:cd17473 26 AQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 125 WAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSlIGWRNVFV--LCILPSMLALLWQLWVLPSMKPESS 202
Cdd:cd17473 106 MTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLvyLLALPVLILVLLFLPEPARKSKSAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 203 GSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHLLARNLRLT 282
Cdd:cd17473 185 SPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR 264
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1730589346 283 LALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVGWSTWLATTVPDE 336
Cdd:cd17473 265 LLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPE 318
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
55-388 |
1.02e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 65.71 E-value: 1.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 55 MAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGG-----FWAMST 129
Cdd:cd06173 35 LVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGiasafFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 130 ATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILpSMLALLWQLWVLPSMKPESSGSLST-- 207
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINAL-SFLLSALLLLFIRRPPPAAPGESSSll 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 208 -------LFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHLLARNLR 280
Cdd:cd06173 194 lrdlregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRR 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 281 LTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVGWSTWLATTVPDE-AESAGGLLVASIQLAISAGAAGG 359
Cdd:cd06173 274 GRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDElRGRVFSVYNALNSGAMPLGALLA 353
|
330 340
....*....|....*....|....*....
gi 1730589346 360 GAVFDLNGASGVFAGSGLLLVTAMVIVFM 388
Cdd:cd06173 354 GLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
13-394 |
2.76e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.49 E-value: 2.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 13 PAKPAWRAVYSLGLGVFGLITAefLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSV 92
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATA--LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 93 LQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKvPKALAVIFSSVSIATVVAAPLGSYL---GSL 169
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA-ASRLNLLHAFFSLGALLGPLLGGLLillGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 170 IGWRNVF-VLCILPSMLALLWQLWVLPSMKPESS---GSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETV 245
Cdd:COG0738 161 LSWHLPYlILAVLLLLLALLFLRSKLPEIEEEEEeaaGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 246 GQASVETISLILLGFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLV-PVG 324
Cdd:COG0738 241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMfPTI 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 325 WStWLATTVPDEAESAGGLLVASIQLAISAGAAGGGAVFDLNGASGVFAGSGLLLVTAMVIVFMGVKVKA 394
Cdd:COG0738 321 FS-LALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
45-334 |
6.67e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 63.37 E-value: 6.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 45 MAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGF 124
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 125 wAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLwqlwVLPSMKPessgs 204
Cdd:cd17504 102 -PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA----LVPLIDL----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 205 lstlfRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLE----TVGQASVETISLILLGFGIANFVGTSVAGHLLARNLR 280
Cdd:cd17504 172 -----RLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGP 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1730589346 281 LTLALVPFAMGVLALMMVAFGHLA-MLDGLLVALWGFAFGLVPVGWSTWLATTVP 334
Cdd:cd17504 247 RRVLLIGLVISAVGLLLLALLHSSlWALVVALLLIGIGLGLAFASLPNIVVESVP 301
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-347 |
7.67e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 63.35 E-value: 7.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 6 AASEAVAPAKPAWRAVYSLGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRW 85
Cdd:COG2807 5 SSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLER 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 86 VLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPaDKVPKALAVIFSSVSIATVVAAPLGSY 165
Cdd:COG2807 85 TLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 166 LGSLIGWRNVFVLCILPSMLALLWQLWVLPSMKPESSGSL--STLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLE 243
Cdd:COG2807 164 LAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPaaASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 244 TVGqASVETISLILLGFGIANFVGTSVAGHLLARNLRLTLALVpfamGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPV 323
Cdd:COG2807 244 DAG-LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLL----LLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG 318
|
330 340
....*....|....*....|....
gi 1730589346 324 GWSTWLATTVPDEAESAGGLLVAS 347
Cdd:COG2807 319 GLFPLALTLIGLRARTPAEAAALS 342
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
38-325 |
1.04e-10 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 62.59 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 38 PASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLL 117
Cdd:cd17315 18 GALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 118 GIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLI--GWRNVFVLCILPSMLallwqLWVLP 195
Cdd:cd17315 98 GLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpgWWRLMFALAAVPALL-----QLLLM 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 196 SMKPESsgslstlfrvlrRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLgfGIANFVGTSVAGHLL 275
Cdd:cd17315 173 FFLPES------------RALLVGVGLQLLQQLTGINAVMYYAPTIFKSAGGGTASILASIIV--GVVNLLATLVAIRLV 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 276 ARNLRLTLALVPFA-----MGVLALMMVAFGHLAM-----LDGLLVALWGFAFGLVPVGW 325
Cdd:cd17315 239 DKVGRRPLLLIGFAgmaasLLLLAIAFLLPALAKAagwlaLLGILLYIAAFAMGAGPVPW 298
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
60-195 |
8.80e-10 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 56.50 E-value: 8.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 60 VTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPAD 139
Cdd:TIGR00880 4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1730589346 140 KVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQLWVLP 195
Cdd:TIGR00880 84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
42-321 |
2.74e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 58.39 E-value: 2.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 42 LTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFF-SVLQIISSLLVAFAPNLHVLLMGRLLLGIA 120
Cdd:cd17490 19 LSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIgLLFTVLASLIMILFPSPWGLLIARFLSGIA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 121 iGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQLWVL-PSMKP 199
Cdd:cd17490 99 -AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKeERREK 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 200 ES-SGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHLLARN 278
Cdd:cd17490 178 KPvLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKK 257
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1730589346 279 LRL-TLALVPFAMGVLALMMVAF-GHLAMLdGLLVALWGFAFGLV 321
Cdd:cd17490 258 LGErNTIIIGFLLLGAYCFLIPFaPNLTLL-YLLQALNGFGTGIL 301
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
15-236 |
3.93e-09 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 58.17 E-value: 3.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 15 KPAWRAVYSLGLGV------FGLITAeflpasLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLM 88
Cdd:PRK03893 16 RAQWKAFSAAWLGYlldgfdFVLITL------VLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 89 FFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGS 168
Cdd:PRK03893 90 ISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVP 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1730589346 169 LIGWRNVFVLCILPSMLAlLWQLWVLPSM-----KPESSGSLSTLFRVLRRPG-MIGGMLATILIFSGHFAFFT 236
Cdd:PRK03893 170 VWGWRALFFIGILPIIFA-LWLRKNLPEAedwkeKHAGKAPVRTMVDILYRGEhRIINILLTLAAAAALWFCFA 242
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
81-324 |
7.39e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 56.80 E-value: 7.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 81 IDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAA 160
Cdd:cd17502 57 FGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 161 PLGSYLGSLIGWRNVFVLCILPSMLALlwqlwvlpsmkpessgslstlfrvLRRPGMIGGMLATILIFSGHFAFFTYLRP 240
Cdd:cd17502 137 LIGGAFTDHLSWRWCFYINLPIGGLAL------------------------ALLRTILLSSIFGFLFGGALFGLIYYLPL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 241 FLETVGQASVETISLILLGFGIANFVGTSVAGHLLARNLRltlaLVPFAMGVLALMMVAFGHLAMLD-GLLVALWGFAFG 319
Cdd:cd17502 193 YFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGR----YKPLIVIGTILMSVGAGLLTTLTlDTSKWLLIGYLI 268
|
....*
gi 1730589346 320 LVPVG 324
Cdd:cd17502 269 LLGLG 273
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
60-325 |
2.05e-08 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 55.74 E-value: 2.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 60 VTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAP---NLHVLLMGRLLLGIAIGGFWAMSTATTMRLV 136
Cdd:pfam00083 52 VSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 137 PAdKVPKALAVIF-SSVSIATVVAAPLG---SYLGSLIGWRNVFVLCILPSMLALLWQLWV------------------- 193
Cdd:pfam00083 132 PK-KLRGALGSLYqLAITFGILLAYIFGlglNKTSNSDGWRIPLGLQLVPALLLIIGLLFLpesprwlvekgrleearev 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 194 --------------------LPSMKPESSGSLSTLFRV--LRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGqasVE 251
Cdd:pfam00083 211 laklrgvpdvdreldeikdsLEAGQEAEKASWKELFSTktRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLG---LS 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 252 TISLILLGFGIANFVGTSVAGHLLARNLRLTLALVPFAmgVLALMMVAFGHLA-------------MLDGLLVALWGFAF 318
Cdd:pfam00083 288 DSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAA--GMAICFVILGIVAllgvsksdwagivAIVFIALFIAFFAM 365
|
....*..
gi 1730589346 319 GLVPVGW 325
Cdd:pfam00083 366 GWGPVPW 372
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
42-330 |
3.98e-08 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 54.88 E-value: 3.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 42 LTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAI 121
Cdd:cd17359 24 LPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 122 GGFWAMSTATTMRLVPADKVPKALAV----IFSSVSIATVVAAPLGSYLGSLI----GWRNVFVLCILPSMLALLWQLWV 193
Cdd:cd17359 104 GGASALVPMYIAEVAPAEIRGRLVSLnqlmIVFGQLLAYIVNYLIANAGGADWlgaeGWRWMLGLEAIPAILFLLGMLFI 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 194 lpsmkPESSgslSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGqASVETISLILLGFGIANFVGTSVAGH 273
Cdd:cd17359 184 -----PESP---RWLVSKGKPILIIGIGLAIFQQFVGINVIFYYGPEIFQNAG-FSENAALLQTIGIGVVNVIFTIIAIL 254
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1730589346 274 LLARNLRLTLALVpfamgvlalmmvafGHLAMLDGLLVALWGFAFGLVPvGWSTWLA 330
Cdd:cd17359 255 LVDKVGRKPLLLI--------------GSIGMAISLLLIGTAFYFAPGS-QASGIVA 296
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
60-325 |
5.07e-08 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 54.20 E-value: 5.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 60 VTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIgGFWAMSTATTMRLVPAD 139
Cdd:cd17360 41 VSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGV-GIASMTVPLYIAEAAPP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 140 KVPKALAVIFS-SVSIATVVAAPLGSYLGSL-IGWRNVFVLCILPSMLALLWQLWVLPSMKpessgslstlFRVLRRPGM 217
Cdd:cd17360 120 RIRGRLVTINVlFITGGQFVAYVINGAFSYLpGGWRWMLGLAAVPAVLQFIGLLFLPESPR----------WPSTRRALI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 218 IGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMM 297
Cdd:cd17360 190 VGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVALVV 269
|
250 260
....*....|....*....|....*...
gi 1730589346 298 VAFGhLAMLdGLLVALWGFAFGLVPVGW 325
Cdd:cd17360 270 LAVW-LALV-GLILYLAFFAPGMGPVPW 295
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
67-188 |
1.20e-07 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 53.35 E-value: 1.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 67 ALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFwamSTATTMRLvpADKVPKALA 146
Cdd:cd17358 54 ALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAA---SVVVPVYI--AEIAPKNVR 128
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1730589346 147 VIFSSVSIATVVAAPLGSY-LGSLIGWRNVFVLCILPSMLALL 188
Cdd:cd17358 129 GALGSLNQLLVNIGILLGYvLGSFLPWRTLALIGAIPPVVFLI 171
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
45-386 |
2.22e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 52.24 E-value: 2.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 45 MAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGF 124
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 125 WAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFV----LCILPSMLALLW-QLWVLPSMKP 199
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVvaglVSILAAVLFWLFyREPPAASAAT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 200 ES-SGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLIL----LGFGIANFVGTSVAGHL 274
Cdd:cd17475 182 ESaSTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLavaqLGGALGRIGLGRVSDRV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 275 LARNLRLTLALVPFAMGVLALMMV--AFGHLAMLDGLLVALWG-FAFGLVPVgWSTWLATTVPDE-AESAGGLLVASIQL 350
Cdd:cd17475 262 FGGRRRPVLVITAAIAAAALLVLSllSPGTPLWLLVLLLILLGlFAIGWNGL-YLTLVAESAGPEqAGTALGLANTINFI 340
|
330 340 350
....*....|....*....|....*....|....*..
gi 1730589346 351 AI-SAGAAGGGAVFDLNGASGVFAGSGLLLVTAMVIV 386
Cdd:cd17475 341 GIaIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
45-193 |
1.19e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 50.05 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 45 MAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGF 124
Cdd:TIGR00895 43 ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGL 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 125 WAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVL-CILPSMLALLWQLWV 193
Cdd:TIGR00895 123 MPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVgGIAPLLLLLLLMRFL 192
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
44-188 |
2.43e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.12 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 44 PMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGG 123
Cdd:cd17365 24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGA 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1730589346 124 FWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALL 188
Cdd:cd17365 104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP 168
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
45-234 |
2.94e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 48.75 E-value: 2.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 45 MAASLGVTEGMAgQAVTATALVAL-VTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGG 123
Cdd:PRK11652 34 MARDLNVREGAV-QAVMAAYLLTYgLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 124 FWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVF----VLCILPSMLALLWQLWVLPSMKP 199
Cdd:PRK11652 113 GGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYlfllLLGAGVTFSMARWMPETRPADAR 192
|
170 180 190
....*....|....*....|....*....|....*
gi 1730589346 200 ESSgSLSTLFRVLRRPGMIGGMLATILIFSGHFAF 234
Cdd:PRK11652 193 RTR-VLASYRTLLSNRRFNCYLLMLIGTLAGIAVF 226
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
57-390 |
3.42e-06 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 48.89 E-value: 3.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 57 GQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGgfWAMSTATtmrLV 136
Cdd:cd17362 42 GLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIG--LAMHAAP---VY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 137 PADKVPKALAVIFSSVSIATVVAAPLGSYLGSLI------GWRNVFVLCILPSMLALLWQLWVLPSMKPESSgslstlfr 210
Cdd:cd17362 117 IAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAfadvvgGWRYMYGLAAPPALLLGIGMWFLPPSPRWQGN-------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 211 vLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHLLARNLRLTLALVPFAM 290
Cdd:cd17362 189 -YRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVSG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 291 GVLALMMVAFGHLAMLDGLLVALW-----------GFAFGLVPVGWsTWLATTVPDEAESAGGLLVASIQLAISAGAAGG 359
Cdd:cd17362 268 MVVSLFLLAAYNLFVQMGPAGLAWlslvalllyvgAYQISFGPISW-LMVSEIFPLRVRGRAIALAVLVNFGSNALVSLA 346
|
330 340 350
....*....|....*....|....*....|..
gi 1730589346 360 -GAVFDLNGASGVFAGSGLLLVTAMVIVFMGV 390
Cdd:cd17362 347 fLPLQELIGLPGTFLGFGVIGVLALLFIYFTV 378
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
49-238 |
7.24e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 47.54 E-value: 7.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 49 LGVTEGMAGQAVTATALVALVTGLLI-TPATKSIDRRWVLMFFSVLQIISSLLVAFAPN-LHVLLMGRLLLGIAIGGF-- 124
Cdd:cd17471 27 LGASPLQIGIFMTLSALSGIVVSQWLgRLSDRGGDRKPLILLALLAGALGYLLFAFLRNyWVLLLVGVVLLSLGAAAFpq 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 125 -WAMSTATTMRlVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQLWVLPSMKPE--S 201
Cdd:cd17471 107 lFALAREYADR-SSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPaqK 185
|
170 180 190
....*....|....*....|....*....|....*..
gi 1730589346 202 SGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYL 238
Cdd:cd17471 186 ATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAM 222
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
17-388 |
7.25e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 47.65 E-value: 7.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 17 AWRAVYSLGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQII 96
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 97 SSLLVAFAPNLHVLLMGRLLLGIA-IGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNV 175
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGgAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 176 FV-------LCILPSMLALLWQLWVL---PSMKPESSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETV 245
Cdd:cd17355 161 LLvlallalLVLVPVLLLLRRRPADLalrAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 246 GqASVETISLILLGFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHlamLDGLLVALWGFAFGLVPVGW 325
Cdd:cd17355 241 G-ISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLP---FPPLALLLFAALFGLGWGAT 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1730589346 326 STWLATTV-----PDEAESAGGLLVASIQLAISAGAAGGGAVFDLNGA-SGVFAGSGLLLVTAMVIVFM 388
Cdd:cd17355 317 VPLTAALAaryfgARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSyTAAWALAVALGLIAALLVLP 385
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
66-319 |
7.30e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 47.55 E-value: 7.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 66 VALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGrllLGIAIGGFWAMSTATTMRLVP---ADKVP 142
Cdd:cd17352 50 VSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLT---YGVLGGLGLGLIYSPAIVIVGqyfEKKRG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 143 KALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLwqlwvlpsmkpessgsLSTLFRVLRRPGMIGGML 222
Cdd:cd17352 127 LATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCV----------------CGLLLRLLKDPTFVLLAL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 223 ATILIFSGHFAFFTYLRPFLETVGqASVETISLILLGFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGH 302
Cdd:cd17352 191 GVSFAMLGFFVPFVYLPSYAKSLG-IDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPL 269
|
250
....*....|....*....
gi 1730589346 303 LAMLDGLLV--ALWGFAFG 319
Cdd:cd17352 270 ATTYVGLIVfsVLFGFCSG 288
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-321 |
8.30e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.59 E-value: 8.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 12 APAKPAWRAVYSLGLGVFGLITAEFLPASLLTP-MAASLGVTEGMAGQAVTATALVALVTGLLI-----TPATKSIDRRW 85
Cdd:COG2211 3 AKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYfYTDVLGLSAALVGLILLVARLWDAITDPLIgalsdRTRTRWGRRRP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 86 VLMFFSVLQIISSLLVAFAPNLHvllmGRLLLGIAIGGFWAMSTATTMRLVP-----ADKVP------KALAVIFSSVSI 154
Cdd:COG2211 83 WILIGAIPLALSFVLLFTAPDLS----PTGKLIYALVTYLLLGLAYTLVNIPysalgAELTPdyeertRLSSWRFAFAGL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 155 ATVVAAPLGSYLGSLI------GWRNVFVLCILPSMLALLWQLWVL---PSMKPESSGSLSTLFRVLRRPGMIGGMLATI 225
Cdd:COG2211 159 GGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTkerPVPEEEKVSLKESLKALLKNRPFLLLLLAYL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 226 LIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHLLARNLR---LTLALVPFAMGVLALMMVAFGH 302
Cdd:COG2211 239 LFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKkkaFIIGLLLAALGLLLLFFLGPGN 318
|
330
....*....|....*....
gi 1730589346 303 LAMLdGLLVALWGFAFGLV 321
Cdd:COG2211 319 LWLL-LVLAALAGIGLGAI 336
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
96-390 |
8.51e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 47.26 E-value: 8.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 96 ISSLLVAFAPNLHVLLMGRLLLGIaIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNV 175
Cdd:cd17391 78 IVIGLMAFVTNVWQLLILRLLQGV-FSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNV 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 176 FVLCILPSMLALLWQLW-VLPSMKPESSGSLSTLFRVLRR----PGMIGGMLATILIFSGHFAFFTYLRPFLE--TVGQA 248
Cdd:cd17391 157 FFITGGLLFLAFLLTLFfVKEDFKPVEKKKMVSTKEVWNSvpnpSLLISLFVTTFIIQLANQSIEPILTLYIRqlMGDAS 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 249 SVETIS-LILLGFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPVGWST 327
Cdd:cd17391 237 NLAFISgLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINS 316
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1730589346 328 WLATTVPDEAESAGGLLVASIQ-LAISAGAAGGGAVFDLNGASGVFAGSGLLLVTAMVIVFMGV 390
Cdd:cd17391 317 LLAKITPKEVAGRIFGYNQSFQyLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
26-324 |
1.17e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.78 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 26 LGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAP 105
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 106 NLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWrnVFVLCILPSML 185
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL--PFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 186 ALLWQLWVLPSMKPESSGSLSTLFRVLRRpgMIGGMLATILIFSGHFAFFTYLRPFLETVGqASVETISLILLGFGIANF 265
Cdd:cd17477 161 ALVPLLLTRRAAPEIEEAESISLRRLLRI--APLALLGAFVAGFLEGAFYSLLPLYGLRLG-LSVAQAALLLAAFVLGGL 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1730589346 266 VGTSVAGHLLAR-NLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWG-FAFGLVPVG 324
Cdd:cd17477 238 LLQWPLGWLADRfDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGgAAGPLYTLA 298
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
83-325 |
1.67e-05 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 46.33 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 83 RRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGgfwAMSTATTMRLvpADKVPKALAVIFSSVSIATVVAAPL 162
Cdd:cd17435 65 RRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSIS---LSSIATCVYI--AEIAPQHRRGLLVSLNELMIVIGIL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 163 GSYLGSLI------GWRNVFVLCILPSMLallwQLWVLPSMKPesSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFT 236
Cdd:cd17435 140 LAYISNYAfanvsnGWKYMFGLVIPLAAL----QAIAMYFLPP--SPRFLVMKDNMRARLLIGLTLVFFVQITGQPNILF 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 237 YLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHLLARNLRLTLALVPFAmgVLALMMVAFGHLAMLDGLLVALWGF 316
Cdd:cd17435 214 YASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSS--VMAVSLVTMGLWLSLASLLVYVAAF 291
|
....*....
gi 1730589346 317 AFGLVPVGW 325
Cdd:cd17435 292 SIGLGPMPW 300
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
81-251 |
2.73e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 45.67 E-value: 2.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 81 IDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGI-AIGgfwAMSTATTMRLVPADKVPKALAVIFSSVSIATVVA 159
Cdd:cd17472 59 IGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSgAIS---SVVMALLADLTREENRTKAMALIGASIGIAFAIS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 160 APLGSYLGSLIGWRNVFVLCILPSMLALLWQLWVLPSMKPESSGSLSTLFRVLRRPGMIGGMLATILIFSGHF---AFFT 236
Cdd:cd17472 136 MVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFvlmAFFY 215
|
170
....*....|....*
gi 1730589346 237 YLRPFLETVGQASVE 251
Cdd:cd17472 216 ILPLLLTQLGGGKGQ 230
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
47-187 |
3.23e-05 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 45.69 E-value: 3.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 47 ASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWA 126
Cdd:PRK12307 46 ADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYA 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1730589346 127 MSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLAL 187
Cdd:PRK12307 126 CASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVI 186
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-198 |
3.76e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.25 E-value: 3.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 20 AVYSLGLGVFGLITAEFLPASLLTP-MAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRR--WVLMFFSVLQII 96
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 97 SSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVF 176
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
170 180
....*....|....*....|..
gi 1730589346 177 VLCILPSMLALLWQLWVLPSMK 198
Cdd:COG2271 341 LLLAALALLAALLALLLLRETR 362
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
35-323 |
3.98e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 45.30 E-value: 3.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 35 EFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGR 114
Cdd:cd17328 15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 115 LLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLI-GWRNVFVLCILPSMLALLWQLWV 193
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 194 LP-----------SMKPESSGSLSTLFRVLRRPGMIGGMLA-TILIFS-GHFAFFTylrPFLET----VGQASVETISLI 256
Cdd:cd17328 175 VRepprgaaeggvMAKSTATSFLADLKALAKNPSFILSTLGfTAVSFVtGALAFWA---PTFFLrafgVGDLSSADVGLI 251
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1730589346 257 LLG-FGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLVPV 323
Cdd:cd17328 252 FGAiTCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGE 319
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
49-192 |
4.16e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.30 E-value: 4.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 49 LGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMS 128
Cdd:cd06173 239 LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1730589346 129 TATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQLW 192
Cdd:cd06173 319 NTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
72-325 |
5.74e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 44.94 E-value: 5.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 72 LLITPATKSIDRRWVLMFFSVLQIISSLLVAFA---PNLHVLLMGRLLLGIAIGgfwAMSTATTMRLVPAdkVPKALAVI 148
Cdd:cd17357 67 FISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACG---LSTGFVPMYLQEI--SPSELRGA 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 149 FSS-----VSIATVVAAPLG--SYLGSLIGWRNVFVLCILPSMLALLWQLWVLPS------------------------- 196
Cdd:cd17357 142 LGSltqigVTLGILLGQVFGlpSVLGTETLWPYLLFFPGIPALLQLAALPFFPESpkflliskgdeeeaekslkflrgie 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 197 ----------------MKPESSGSLSTLFRV--LRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGqASVETISLILL 258
Cdd:cd17357 222 ddvdqeleeikkeseqMGDQKQVSLMQLLRDpsLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAG-FSPQLAEWANL 300
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1730589346 259 GFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAMLD------GLLVAL----WGFAFGLVPVGW 325
Cdd:cd17357 301 GIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQnswmsyGCIVAIflfiFFFAIGLGPIPW 377
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
26-189 |
6.03e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.84 E-value: 6.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 26 LGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAP 105
Cdd:cd17370 206 LLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGS 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 106 NLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSML 185
Cdd:cd17370 286 SLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
....
gi 1730589346 186 ALLW 189
Cdd:cd17370 366 ALLL 369
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
45-317 |
6.86e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.53 E-value: 6.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 45 MAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGF 124
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 125 WAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLiGWRNVFVLCILPSMLALLWQLWVLPSMKP----- 199
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPETRPkrraa 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 200 ESSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHLLARNL 279
Cdd:cd17329 185 EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270
....*....|....*....|....*....|....*...
gi 1730589346 280 RLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFA 317
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLG 302
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
60-300 |
1.04e-04 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 44.16 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 60 VTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLL-VAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPA 138
Cdd:cd17356 51 VSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIqVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPK 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 139 DKVPKALAVIFSSVSIATVVAAPLG---SYLGSLIGWRNVFVLCILPSMLALLWQLWVlpsmkPESSgslstlfRVLRRP 215
Cdd:cd17356 131 HIRGTLVSLYQLAITIGILVAYCINygtHKLDGSAQWRIPLGLQIVWGLLLLIGMFFL-----PESP-------RWLYRT 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 216 gMIGGMLATILIFSGHFAFFTYLRPFLETVGqASVETISLILLGFGIANFVGTSVAGHLLARNLRLTLALVPFAMGVLAL 295
Cdd:cd17356 199 -ILGIMLQLFQQLTGINYFFYYGTTIFQSTG-LTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIGAAGMSICL 276
|
....*
gi 1730589346 296 MMVAF 300
Cdd:cd17356 277 FIYAA 281
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
84-195 |
1.29e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 43.70 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 84 RWVLMFFSVLQIISSLLVAFAP--NLHVLLMGRLLLGIAIGgfWAMSTATTM--RLVPADKVPKALAVIFSSVSIATVVA 159
Cdd:cd17380 64 KKVLLLAVALWSLATLLTPLLAysSLPLLILSRILLGLGEG--VHFPSMTSLfsRWVPVSERSRAVSIVTAGSYLGTLLG 141
|
90 100 110
....*....|....*....|....*....|....*..
gi 1730589346 160 APLGSYLGSLIGWRNVFVLCILPSML-ALLWQLWVLP 195
Cdd:cd17380 142 GLIGPLLLEYYGWPSVFYFFGLLGLLwALVWLIYLPP 178
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
72-280 |
1.43e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 43.72 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 72 LLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSS 151
Cdd:cd17323 52 LIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 152 VSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQLWVLPSMkpessgSLSTLFrvlrrpgmiggmlaTILIFSGH 231
Cdd:cd17323 132 PLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPIV------LLLGLY--------------VGLVYAIL 191
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1730589346 232 FAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVAGHLLARNLR 280
Cdd:cd17323 192 YLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYR 240
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
37-188 |
1.94e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.38 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 37 LPASLLTPMAASLGvTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLL 116
Cdd:cd06179 16 LPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQAL 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1730589346 117 LGIAIGGFwAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYL--GSLIGWRNVFVLCILPSMLALL 188
Cdd:cd06179 95 IGIGAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIFNALALI 167
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
58-122 |
5.21e-04 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 41.85 E-value: 5.21e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1730589346 58 QAVTATA-LVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIG 122
Cdd:cd17361 54 QLFTSSLyLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVG 119
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
83-388 |
6.29e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 6.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 83 RRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFwAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPL 162
Cdd:cd17330 63 RKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPAL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 163 GSYLGSLIGWRNVFVLCILPSMLALLWQLWVLPsmkpessgslsTLFRVLrrpgmiggmLATILIFSGHFAFFTYLRPFL 242
Cdd:cd17330 142 GGFLSTPYGYALPFLVAAALALLNLVLVLFFLP-----------PLRRLL---------LVYFLIALAFAGLESVFSLFL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 243 ETVGQASVETISLILLGFGIAN-FVGTSVAGHLLARNLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGLV 321
Cdd:cd17330 202 KDRFGFSPSQIGLLLALVGIAGiLAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIV 281
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1730589346 322 PVGWSTWLATTVPDEAESAG-GLLVASIQLAISAGAAGGGAVFDLNGASGVFAGSGLLLVTAMVIVFM 388
Cdd:cd17330 282 FPALSALLSKSVPSKEQGKAqGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
87-320 |
8.55e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 41.07 E-value: 8.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 87 LMFFSVLqiISSLLVAFAP-----NLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAP 161
Cdd:cd17318 88 VLGYSIL--ITALLTLLTPlaargGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMP 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 162 LGSYLGSLIGWRNVF-VLCILPSMLALLWQLWVLPsmkpessgslstlfrvlrrpgMIGGMLATILIFSGHFAFFTYLRP 240
Cdd:cd17318 166 LSGFLCESLGWPSIFyIFGGLGLLWCLLWFFLVLP---------------------VWAIVVAHFGHNWGFYTLLTELPT 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 241 FLETVGQASVETI----SLILLGFGIANFVGTSVAGHLLARNLRLTLA----LVPFAMGVLALMMVAFGHLAMLDGLLVA 312
Cdd:cd17318 225 YMSDVLHFNIKSNgflsSLPYLAMWICSIVGGYLADWLRSRGILSTTTvrklFTSIGFLGPGVFLIALGYLGSNATLAVV 304
|
....*...
gi 1730589346 313 LWGFAFGL 320
Cdd:cd17318 305 FLTLSVGL 312
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
36-320 |
9.23e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 41.08 E-value: 9.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 36 FLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFA-PNLHVLLMGR 114
Cdd:cd17341 16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 115 LLLGIAIGGFwAMSTATTMRLVPADKVPKALAVIF-------SSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLAL 187
Cdd:cd17341 96 FLLGFAGANF-ASGQPWASFWFPKEKIGGAAGGIAgagnmgvAVSQLLAPLIAGAIVFDGGFVGWRNAFFVPGILLAIAA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 188 LWQL---WVLPSMKPESSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILLGFGIAN 264
Cdd:cd17341 175 VLVLlfgDDLPTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAG 254
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1730589346 265 FVGTSVAGHLLAR-NLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFAFGL 320
Cdd:cd17341 255 ALARPAGGWLSDRfGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGL 311
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
64-215 |
9.73e-04 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 41.02 E-value: 9.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 64 ALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIggfwAMSTATTMRLVpADKVP- 142
Cdd:cd17384 41 ALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGS----ACSSVAGMGML-ASLYPd 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1730589346 143 -----KALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQLWVL-PSMKPESSGSLSTLFRVLRRP 215
Cdd:cd17384 116 dkergKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILqPSVKSEESEEGTPWKTLLKDP 194
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
162-387 |
1.22e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 162 LGSYLGSLI----------GWRNVFVLCILPSMLALLWQLWVLPSMKPESSGSLSTLFRVLRRPGMIggmLATILIFSGH 231
Cdd:cd17370 135 LGAVLGPLLaalllyllggNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKA---FWLYLLAVAL 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 232 FAFFTYLRPFLETVGQASVETISLILLGFGIANFVGTSVA---GHLLARNLRLTLALVPFAMGVLALMMVAFGHLAMLDG 308
Cdd:cd17370 212 FALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAypaGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLL 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 309 LLVALWGFAFGLVPVGWSTWLATTVPDEAE-SAGGLLVASIQLAISAGAAGGGAVFDLNGASGVFAGSGLLLVTAMVIVF 387
Cdd:cd17370 292 LGFILWGLYMGAQESIERAAVADLVPAELRgTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
24-170 |
1.57e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 24 LGLGVFGLITAEFLPASLLTPMAAS-LGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVA 102
Cdd:COG2211 233 LLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF 312
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1730589346 103 FAPNLHVLLM--GRLLLGIAIGGFWAMSTATTMRLVPADKV---PKALAVIFSSVSIATVVAAPLGSYLGSLI 170
Cdd:COG2211 313 FLGPGNLWLLlvLAALAGIGLGAILVLPWAMLADVVDYDEWktgRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
56-194 |
1.76e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 56 AGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRL 135
Cdd:cd17489 229 AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDL 308
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1730589346 136 VPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQLWVL 194
Cdd:cd17489 309 VPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
36-236 |
2.33e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 39.90 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 36 FLPAslLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRL 115
Cdd:PRK11102 10 YLPA--LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 116 LLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQLWVLP 195
Cdd:PRK11102 88 LHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP 167
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1730589346 196 -SMKPES------SGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFT 236
Cdd:PRK11102 168 eTLPKERrqpfhlRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLT 215
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
55-194 |
3.99e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.17 E-value: 3.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 55 MAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMR 134
Cdd:cd17391 241 ISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAK 320
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 135 LVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFVLCILPSMLALLWQLWVL 194
Cdd:cd17391 321 ITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
36-323 |
4.41e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.82 E-value: 4.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 36 FLPASLLTPMAAS-LGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFA-PNLHVLLMG 113
Cdd:TIGR00886 18 FAFSPLAVFLIKDdLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 114 RLLLGIAIGGFwAMSTATTMRLVPADKVPKALAVIF----SSVSIATVVAAPLGSYLGSLIG--------WRNVFV---L 178
Cdd:TIGR00886 98 RLFIGIAGGSF-ASCMPWISFFFPKKIQGTALGLAAgwgnMGGGVAQFVMPPIIGSLIFGGGqpahlawgWAFVIVpagI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 179 CILPSMLALLWQLWVLPSMKPESSGSLSTLFRVLRRPGMIGGMLATILIFSGHFAFFTYLRPFLETVGQASVETISLILL 258
Cdd:TIGR00886 177 LLLPALLIFFVGADTPPGKPATGKLSFKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYAS 256
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1730589346 259 GFGIANFVGTSVAGHLL-----ARNLRLTLALVPFAMGVLALMMVAFGHLAMLDGLLVALWGFA-------FGLVPV 323
Cdd:TIGR00886 257 LGGFLGSLARPAGGAISdrlggARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFFFAgagngstFALVPH 333
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
45-188 |
5.30e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 38.79 E-value: 5.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 45 MAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGF 124
Cdd:PRK11551 41 MAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGA 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 125 WAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIGWRNVFV------LCILPSMLALL 188
Cdd:PRK11551 121 LPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYvggvgpLLLVPLLMRWL 190
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
65-122 |
5.44e-03 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 38.54 E-value: 5.44e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1730589346 65 LVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIG 122
Cdd:cd17437 43 IISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVG 100
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-203 |
7.76e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.32 E-value: 7.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 19 RAVYSLGLGVFGLITAEFLPASLLTPMAAS-LGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIIS 97
Cdd:COG2223 205 PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 98 SLLVAFAP-NLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVAAPLGSYLGSLIG-WRNV 175
Cdd:COG2223 285 LLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAA 364
|
170 180
....*....|....*....|....*...
gi 1730589346 176 FVLCILPSMLALLWQLWVLPSMKPESSG 203
Cdd:COG2223 365 FLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-159 |
8.95e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.03 E-value: 8.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 24 LGLGVFGLITAEFLPASLLTPMAASLGVTEGMAGQAVTATALVALVTGLLITPATKSIDRRWVLMFFSVLQIISSLLVAF 103
Cdd:COG2814 213 LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL 292
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1730589346 104 APNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVA 159
Cdd:COG2814 293 AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
83-201 |
9.78e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 38.07 E-value: 9.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730589346 83 RRWVLMFFSVLQIISSLLVAFAPNLHVLLMGRLLLGIAIGGFWAMSTATTMRLVPADKVPKALAVIFSSVSIATVVaAPL 162
Cdd:TIGR00898 156 RKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVL-LPL 234
|
90 100 110
....*....|....*....|....*....|....*....
gi 1730589346 163 GSYLgsLIGWRNVFVLCILPSMLALLWQLWVlpsmkPES 201
Cdd:TIGR00898 235 VAYF--IPDWRWLQLAVSLPTFLFFLLSWFV-----PES 266
|
|
| |
