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Conserved domains on  [gi|1730614835|gb|TYF91125|]
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MarR family transcriptional regulator [Klebsiella grimontii]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-134 3.38e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 98.12  E-value: 3.38e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730614835   5 NEAFHLLRQLFQQHTARW--QLELPDLTKPQYAVMRSIAEHPGIEQVTLTEAAVSTKATLAEMLSRMESRGLVRREHDPA 82
Cdd:COG1846    10 ERLGLLLRRLARALRRALdrALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1730614835  83 DKRRRFVYLTAEGEALLASSMPLGHAVDEEFLGRLSDEERQQFSQIIHKLMA 134
Cdd:COG1846    90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-134 3.38e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 98.12  E-value: 3.38e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730614835   5 NEAFHLLRQLFQQHTARW--QLELPDLTKPQYAVMRSIAEHPGIEQVTLTEAAVSTKATLAEMLSRMESRGLVRREHDPA 82
Cdd:COG1846    10 ERLGLLLRRLARALRRALdrALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1730614835  83 DKRRRFVYLTAEGEALLASSMPLGHAVDEEFLGRLSDEERQQFSQIIHKLMA 134
Cdd:COG1846    90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
28-122 4.11e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 81.49  E-value: 4.11e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730614835   28 DLTKPQYAVMRSIAEHPGIEQVTLTEAAVSTKATLAEMLSRMESRGLVRREHDPADKRRRFVYLTAEGEALLASSMPLGH 107
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARS 86

                           90
                   ....*....|....*
gi 1730614835  108 AVDEEFLGRLSDEER 122
Cdd:smart00347  87 ETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-85 3.90e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 54.86  E-value: 3.90e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1730614835  29 LTKPQYAVMRSIAEHPGIEQVTLTEAAVSTKATLAEMLSRMESRGLVRREHDPADKR 85
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRR 57
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
28-133 1.89e-06

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 44.50  E-value: 1.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730614835  28 DLTKPQYAVMRSIAEHPGIEQVTLTEAAVSTKATLAEMLSRMESRGLVRREHDPADKRRRFVYLTAEGEALLASSMPL-G 106
Cdd:PRK11512   37 DITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQCHQLvG 116

                          90       100
                  ....*....|....*....|....*..
gi 1730614835 107 HAVDEEFLGRLSDEERQQFSQIIHKLM 133
Cdd:PRK11512  117 QDLHQELTKNLTADEVATLEHLLKKVL 143
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-134 3.38e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 98.12  E-value: 3.38e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730614835   5 NEAFHLLRQLFQQHTARW--QLELPDLTKPQYAVMRSIAEHPGIEQVTLTEAAVSTKATLAEMLSRMESRGLVRREHDPA 82
Cdd:COG1846    10 ERLGLLLRRLARALRRALdrALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1730614835  83 DKRRRFVYLTAEGEALLASSMPLGHAVDEEFLGRLSDEERQQFSQIIHKLMA 134
Cdd:COG1846    90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
28-122 4.11e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 81.49  E-value: 4.11e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730614835   28 DLTKPQYAVMRSIAEHPGIEQVTLTEAAVSTKATLAEMLSRMESRGLVRREHDPADKRRRFVYLTAEGEALLASSMPLGH 107
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARS 86

                           90
                   ....*....|....*
gi 1730614835  108 AVDEEFLGRLSDEER 122
Cdd:smart00347  87 ETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-85 3.90e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 54.86  E-value: 3.90e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1730614835  29 LTKPQYAVMRSIAEHPGIEQVTLTEAAVSTKATLAEMLSRMESRGLVRREHDPADKR 85
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRR 57
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 28-86 1.75e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 47.97  E-value: 1.75e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1730614835  28 DLTKPQYAVMRSIAEHPGIEQVTLTEAAVSTKATLAEMLSRMESRGLVRREHDPADKRR 86
Cdd:pfam12802   2 GLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_27 pfam13463
Winged helix DNA-binding domain;
29-95 1.14e-07

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 46.13  E-value: 1.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1730614835  29 LTKPQYAVMRSI-AEHPGIEQVTLTEAAVSTKATLAEMLSRMESRGLVRREHDPADKRRRFVYLTAEG 95
Cdd:pfam13463   1 LTRLEALILHNIgHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
28-133 1.89e-06

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 44.50  E-value: 1.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730614835  28 DLTKPQYAVMRSIAEHPGIEQVTLTEAAVSTKATLAEMLSRMESRGLVRREHDPADKRRRFVYLTAEGEALLASSMPL-G 106
Cdd:PRK11512   37 DITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQCHQLvG 116

                          90       100
                  ....*....|....*....|....*..
gi 1730614835 107 HAVDEEFLGRLSDEERQQFSQIIHKLM 133
Cdd:PRK11512  117 QDLHQELTKNLTADEVATLEHLLKKVL 143
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 26-96 1.96e-04

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 37.59  E-value: 1.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1730614835  26 LPDLTKPQYAVMRSIAEHPG-IEQVTLTEAAVSTKATLAEMLSRMESRGLVRREHdpaDKRRRFVYLTAEGE 96
Cdd:COG2512    10 YPELLEDERRVLELLRENGGrMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKER---VGRENVVELPEDEP 78
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
58-98 1.29e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 36.33  E-value: 1.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1730614835  58 TKATLAEMLSRMESRGLVRREhdpadkRRRFVYLTAEGEAL 98
Cdd:COG1321    37 SPPSVTEMLKKLEEKGLVEYE------PYGGITLTEEGREL 71
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 45-132 1.58e-03

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 36.52  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730614835  45 GIEQVTLteaaVSTkatlaemLSRMESRGLVRREHDPADKRRRFVYLTAEGEALLASSMPLGHAVDEEFLGRLSDEERQQ 124
Cdd:PRK03573   57 GIEQPSL----VRT-------LDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIEQ 125


                  ....*...
gi 1730614835 125 FSQIIHKL 132
Cdd:PRK03573  126 LITLIAKL 133
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 42-138 2.67e-03

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 36.26  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730614835  42 EHPGIEQVTLTEAAVSTKATLAEMLSRMESRGLVRREHDPADKRRRFVYLTAEGEALLASSMPLGHAVDEEFLGRLSDEE 121
Cdd:PRK10870   68 ENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTE 147

                          90
                  ....*....|....*..
gi 1730614835 122 RQQFSQIIHKLMAQEQQ 138
Cdd:PRK10870  148 KDQLEQITRKLLSRLDQ 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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