|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
24-432 |
2.27e-45 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 161.23 E-value: 2.27e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 24 FGIISFSLLITGFLSYSGNIVLAKLVS--NGWSNNYLNATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISA 101
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 102 CAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLS----WRM 177
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 178 MFLLGGAAMLLAWYLsgkyfiesprwlagkgqrnaaekhllqvelqiekeksitlppwqgagpaepcaesgsfwllfkgq 257
Cdd:cd17316 161 LFLIGALPALLALLL----------------------------------------------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 258 mLRRTLVAITVLIAMNISLYTITVWIPTIFV-NSGIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR--LFGSSLLMI 334
Cdd:cd17316 176 -RRRTLLLILLWFFISFGYYGLTTFLPTYLQtVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKktLVIGLILSG 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 335 IALLGYVYSIQTAEWAILsYGLVMIFFLYMYVCFASAVYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGS 414
Cdd:cd17316 255 ILALPLFYLLSGSPTLLL-LLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
|
410
....*....|....*...
gi 1730619405 415 IRVFIVLGVMLVLCALIL 432
Cdd:cd17316 334 TGVPALILALLAIVALIV 351
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
54-446 |
3.01e-32 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 128.21 E-value: 3.01e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 54 SNNYLNATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYA 133
Cdd:TIGR00898 124 EDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVV 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 134 SFTEFIPPAVRGkWSARLSFVGnWSpmlsaaIGVVVIAFL-----SWRMMFLL----GGAAMLLAWYLsgkyfIESPRWL 204
Cdd:TIGR00898 204 LNTEFLPKKQRA-IVGTLIQVF-FS------LGLVLLPLVayfipDWRWLQLAvslpTFLFFLLSWFV-----PESPRWL 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 205 AGKGQRNAAE-----------KHLLQVELQIEKEKSITLPPWQgagpaepcaeSGSFWLLFKGQMLRRTLVAITVLIAMN 273
Cdd:TIGR00898 271 ISQGRIEEALkilqriakingKKLPAEVLSLSLEKDLSSSKKQ----------YSFLDLFRTPNLRKTTLCLMMLWFTTA 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 274 ISLYTITVWIPTIFVNSGIDVtksILMTAIIMIGApvgiFIAALIIDRFPRR--------LFGSSLLMIIALLGYVYSIQ 345
Cdd:TIGR00898 341 FSYYGLVLDLGNLGGNIYLDL---FISGLVELPAK----LITLLLIDRLGRRytmaasllLAGVALLLLLFVPVDLYFLR 413
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 346 TAeWAILSYGLVMIFFLYMYvcfasaVYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYgvALLLTRYGSIRVFIVLGVML 425
Cdd:TIGR00898 414 TA-LAVLGKFGITSAFQMVY------LYTAELYPTVVRNLGVGVCSTMARVGSIISPF--LVYLGEKWLFLPLVLFGGLA 484
|
410 420
....*....|....*....|.
gi 1730619405 426 VLCAlILFCFGIETRKVSLEE 446
Cdd:TIGR00898 485 LLAG-ILTLFLPETKGVPLPE 504
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
15-409 |
3.95e-31 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 123.62 E-value: 3.95e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 15 PLSRFHFRIFGIISFSLLITGF----LSYSgnivlAKLVSNGWSNNYLNATFT-SALMFGYFIGSLTGGFMGDYLGRRKA 89
Cdd:TIGR00895 10 PLSRYQWRAIILSFLIMLMDGYdlaaMGFA-----APAISAEWGLDPVQLGFLfSAGLIGMAFGALFFGPLADRIGRRRV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 90 FRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKwSARLSFVG-NWSPMLSAAIGVV 168
Cdd:TIGR00895 85 LLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGT-AVGLMFCGyPIGAAVGGFLAGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 169 VIAFLSWRMMFLLGGAAMLLAWYLSGKYFIESPRWLAGKGQRNAAEKhLLQVELQIEKEKSITLPPwqgaGPAEPCAESG 248
Cdd:TIGR00895 164 LIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRI-VNAIAPQMQAEAQSALPE----QKSTQGTKRS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 249 SFWLLFKGQMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRRLFG 328
Cdd:TIGR00895 239 VFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 329 SSLLMIIALLGYVYSIQTAEWAILSYGLVM-IFFLYMYVCFASavYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVAL 407
Cdd:TIGR00895 319 LLLLLGAVFAVLVGSTLFSPTLLLLLGAIAgFFVNGGQSGLYA--LMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGY 396
|
..
gi 1730619405 408 LL 409
Cdd:TIGR00895 397 LL 398
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-441 |
9.27e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 116.12 E-value: 9.27e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 17 SRFHFRIFGIISFSLLITGFLSYSGNIVLAKLVSN-GWSNNYLnATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLL 95
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADlGLSAAQL-GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 96 IVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSW 175
Cdd:COG2271 84 LWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 176 RMMFLLGGAAMLLAwylsgkyfiesprwlagkgqrnaaekhllqvelqiekeksitlppwqgagpaepcaesgsfwllfk 255
Cdd:COG2271 164 RAAFLILGLPGLLL------------------------------------------------------------------ 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 256 gqMLRRTLVAITVLIAMNISLYTITVWIPTIFVNS-GIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR----LFGSS 330
Cdd:COG2271 178 --ALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrklvLAIGL 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 331 LLMIIALLGYVYSiqTAEWAILSYGLVMIFFLYMYVCFASAvYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLT 410
Cdd:COG2271 256 LLAALALLLLALL--PSPALAIALLFLAGFGLGGAFGLLWA-LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD 332
|
410 420 430
....*....|....*....|....*....|.
gi 1730619405 411 RYGSIRVFIVLGVMLVLCALILFCFGIETRK 441
Cdd:COG2271 333 ATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
62-450 |
3.23e-27 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 113.14 E-value: 3.23e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 62 FTSALMFGYFIGSLTGGFMGDYLGRRKAFRVN--LLIVGISACAATFVPNMYWLIFF-RCLMGCGMGALIMVGYASFTEF 138
Cdd:pfam00083 51 IVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIAnvLFVIGAVLQGAAKGKWSVYQLIVgRVLVGIGVGGASVLAPMYISEI 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 139 IPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFL-SWRMMFLLGGAAMLLAWYLSGKYFI-ESPRWLAGKGQRNAAEKH 216
Cdd:pfam00083 131 APKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSnSDGWRIPLGLQLVPALLLIIGLLFLpESPRWLVEKGRLEEAREV 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 217 LLQ---VELQIEKEKSITLPPWQGAgpaepcAESGSFWLLFKGQMLRRTLVAITVLIAMNISLYTITVWI---PTIFVNS 290
Cdd:pfam00083 211 LAKlrgVPDVDRELDEIKDSLEAGQ------EAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFyysTTIFENL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 291 GidVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR---LFGSSLLMIIAL-LGYVYSIQTAEWAILSYglVMIFFLYMYV 366
Cdd:pfam00083 285 G--LSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRpllLLGAAGMAICFViLGIVALLGVSKSDWAGI--VAIVFIALFI 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 367 CFASA-------VYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIRVFIVLGVMLVLCALILFCFGIET 439
Cdd:pfam00083 361 AFFAMgwgpvpwVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPET 440
|
410
....*....|.
gi 1730619405 440 RKVSLEEISSL 450
Cdd:pfam00083 441 KGRTLEEIDEL 451
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
52-432 |
1.59e-25 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 107.39 E-value: 1.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 52 GWSNNYLNATFTSALMFGYfIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVG 131
Cdd:cd17371 30 GLDEAEAGLLGTVTLAGGA-IGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 132 YASFTEFIPPAVRGKwsaRLSFVgnwspMLSAAIGVVVIAFLS------------WRMMFLLGGAAMLLAWYLSgKYFIE 199
Cdd:cd17371 109 AALMAEYVPARHRGK---ALGYV-----QSGWAVGWLLATLLAallfpllppeiaWRVLFLLGALPALLVLFIR-RFVKE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 200 SPRWLAGKGQRNAAEKHLlqvelqiekeksitlppwqgagpaepcaesgSFWLLFKGQMLRRTLVAITVLIAMNISLYTI 279
Cdd:cd17371 180 PPQWQAARAARRHFADRP-------------------------------SLRELFSPPLLRTTLLASLLATGALGGYYGI 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 280 TVWIPTIFVNS-GIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR--LFGSSLLMIIALLGYVYSiqTAEWAILSYGL 356
Cdd:cd17371 229 TTWLPSYLTGErGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRnnFALFALGSAISILLYFFL--PLSPTLILILG 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1730619405 357 VMIFFLYMYVCFASAVYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIRVFIVLGVMLVLCALIL 432
Cdd:cd17371 307 FPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVL 382
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-443 |
4.04e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 100.34 E-value: 4.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 20 HFRIFGIISFSLLITGFLSYSGNIVLAKLVSN-GWSNNYLnATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVG 98
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEfGLSAAQL-GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 99 ISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMM 178
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 179 FLLGGAAMLLAWYLSGKYFIESPRwlagkgQRNAAEKHLLQVELQIEKEKSitlppwqgagpaepcaesgsFWLLFkgqm 258
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPA------GAAAAAKASLRDQLEALRDPR--------------------FWLLS---- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 259 lrrtlvaiTVLIAMNISLYTITVWIPTIFVNS-GIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR--LFGSSLLMII 335
Cdd:COG2223 212 --------LLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRrvLLIVFALMAL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 336 ALLGYVYSIQTAEWAILsyGLVMIFFLYMYVCFASAVYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSI 415
Cdd:COG2223 284 GLLLLALALGSLWLFLV--LFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSY 361
|
410 420
....*....|....*....|....*....
gi 1730619405 416 R-VFIVLGVMLVLCALILFCFGIETRKVS 443
Cdd:COG2223 362 TaAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-396 |
5.89e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 99.28 E-value: 5.89e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 17 SRFHFRIFGIISFSLLITGFLSYSGNIVLAKLVSNGWSNNYLNATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLI 96
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 97 VGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWR 176
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 177 MMFLLGGAAMLLAWYLSGKYFIESPrwlagkgqrnaaekhllqvelqiekeksitlppwqgagPAEPCAESGSFWLLFKg 256
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESR--------------------------------------PAARARLRGSLRELLR- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 257 qmLRRTLVAITVLIAMNISLYTITVWIPTIFVN-SGIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR--LFGSSLLM 333
Cdd:COG2814 206 --RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRrlLLIGLLLL 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1730619405 334 IIALLGYVYSIQTAEWAIlsyGLVMIFFLYMYVCFASAVYVPELWPTHLRLRGSGFVNAIGRI 396
Cdd:COG2814 284 ALGLLLLALAGSLWLLLL---ALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
62-447 |
1.18e-22 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 100.11 E-value: 1.18e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 62 FTSALMFGYFIGSLTGGFMGDYLGRRKAFR-VNLLIV--GISACAATFVPNMYWLIFFRCLMG--CGMGALIMVGYASft 136
Cdd:TIGR00879 76 VVSIFLVGGFIGALFAGWLSDRFGRKKSLLiIALLFVigAILMGLAAFALSVEMLIVGRVLLGigVGIASALVPMYLS-- 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 137 EFIPPAVRGKwsarlsfvGNWSPMLSAAIGVVVIAF-----------LSWRMMFLLGGAAMLLAwyLSGKYFI-ESPRWL 204
Cdd:TIGR00879 154 EIAPKALRGA--------LTSLYQLAITFGILVAYGfgsgkvslnntLGWRIPLGLQLIPAGLL--FLGLFFLpESPRWL 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 205 AGKGQRNAAEKHLLQVELQIEKEKSI--TLPPWQGAGPAEPC---AESGSFWLLFKGQMLRRTLVAITVLIAMNISLYTI 279
Cdd:TIGR00879 224 VGKGRVEEARKSLARLRGTSGEDKELldELELIDIKRSIEKRsvqPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAI 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 280 TVWIPTIFVNSGIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR------LFGSSLLM-IIALLGYVYSIQTAEWAil 352
Cdd:TIGR00879 304 MYYSPTIFENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRpllligAAGMAICLfVLGILGASFVTGSSKSS-- 381
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 353 syGLVMIFFLYMYVCFASA-------VYVPELWPTHLRLRGSGFV----NAIGRIVAVFTPYGVALLltryGSIRVFIVL 421
Cdd:TIGR00879 382 --GNVAIVFILLFIAFFAMgwgpvpwVIVSEIFPLSLRPKGISIAvaanWLANFIVGFLFPTMLESI----GVGGVFIFF 455
|
410 420
....*....|....*....|....*.
gi 1730619405 422 GVMLVLCALILFCFGIETRKVSLEEI 447
Cdd:TIGR00879 456 GGLNVLGLIFVYFFLPETKGRTLEEI 481
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
62-446 |
4.65e-22 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 98.03 E-value: 4.65e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 62 FTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPP 141
Cdd:cd17358 46 FGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPK 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 142 AVRGkwsaRLSFVgnwsPMLSAAIGVVVI----AFLSWRMMFLLGGAAMLLawYLSGKYFI-ESPRWLAGKGQRNAAEKH 216
Cdd:cd17358 126 NVRG----ALGSL----NQLLVNIGILLGyvlgSFLPWRTLALIGAIPPVV--FLILLFFIpESPRWLAKKGREEEAEKS 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 217 lLQVELQIEKEKSITLPPWQGAGPAEPCAESGSFWLLFKGQMLRRTLVAITVLIAMN--ISLYTITVWIPTIF--VNSGI 292
Cdd:cd17358 196 -LQFLRGKDADISKEAAEIQEELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQqlSGINAVIFYASSIFdeAGSGL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 293 DVTKSILMTAIIMIgapVGIFIAALIIDRFPRR--LFGSSLLMIIA--LLGYVYSIQTAEWAILSYGLVMIFFLYMYVCF 368
Cdd:cd17358 275 DPNTATIIIGVVQV---VGTLVATLLVDRLGRRplLLVSAIGMGIGllALGLYFYLQEHGALLSSVSWLPLVGLVIYIIS 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 369 ASAVYVP-------ELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIRVFIVLGVMLVLCALILFCFGIETRK 441
Cdd:cd17358 352 FSIGLGPlpwvimsEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPETKG 431
|
....*
gi 1730619405 442 VSLEE 446
Cdd:cd17358 432 KSLEE 436
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
63-431 |
2.52e-20 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 92.25 E-value: 2.52e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 63 TSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPA 142
Cdd:cd17359 42 VSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 143 VRGKWSAR----------LSFVGNWspMLSAAIGVVVIAFLSWRMMFLLGGAAMLLawYLSGKYFI-ESPRWLAGKGQRn 211
Cdd:cd17359 122 IRGRLVSLnqlmivfgqlLAYIVNY--LIANAGGADWLGAEGWRWMLGLEAIPAIL--FLLGMLFIpESPRWLVSKGKP- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 212 aaekhllqvelqiekeksitlppwqgagpaepcaesgsfwLLFKGQMlrrtLVAITVLIAMNISLYtitvWIPTIFVNSG 291
Cdd:cd17359 197 ----------------------------------------ILIIGIG----LAIFQQFVGINVIFY----YGPEIFQNAG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 292 IDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR---LFGSSLLMII-ALLGYVYSI----QTAEWAILSYGLVMIFFLY 363
Cdd:cd17359 229 FSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKpllLIGSIGMAISlLLIGTAFYFapgsQASGIVALVLILLFVAFFA 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1730619405 364 MYVCFASAVYVPELWPTHLRLRGSG---FVNAIGR-IVAVFTPygvaLLLTRYGSIRVFIVLGVMLVLCALI 431
Cdd:cd17359 309 MSWGPVTWVLLSEIFPNRIRGLAMGiavFFLWIANfLVSLTFP----ILLAAFGLAFTFLIFAVICVLAFLF 376
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
63-402 |
1.26e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 86.70 E-value: 1.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 63 TSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPA 142
Cdd:pfam07690 38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 143 VRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLsgKYFIESPRWLAGKGQRNAAEKhllqvel 222
Cdd:pfam07690 118 ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL--LLLPRPPPESKRPKPAEEARL------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 223 qiekeksitlppwqgagpaepcaesgSFWLLFKGQMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVTKSILMTA 302
Cdd:pfam07690 189 --------------------------SLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 303 IIMIGAPVGIFIAALIIDRFPRR--LFGSSLLMIIALLGYVYSIQTAEWAILSYGLVMIFFLYMYVCFASAVYVPELWPT 380
Cdd:pfam07690 243 LGGLLGAIGRLLLGRLSDRLGRRrrLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPK 322
|
330 340
....*....|....*....|..
gi 1730619405 381 HLRLRGSGFVNAIGRIVAVFTP 402
Cdd:pfam07690 323 EERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
64-434 |
3.70e-17 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 82.25 E-value: 3.70e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 64 SALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAV 143
Cdd:cd17365 41 SAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 144 RGKWSArLSFVG-NWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLawylsgkyfiesprwlagkgqrnaaekhllqvel 222
Cdd:cd17365 121 RSLAVT-LMFCGyPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLI---------------------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 223 qiekeksitLPPwqgagpaepcaesgsfwllfkgqMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVTKSILMTA 302
Cdd:cd17365 166 ---------LLP-----------------------LLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 303 IIMIGAPVGIFIAALIIDRFPRRLFGSSLLMIIALLGYVYSIQTAEWAILsygLVMIFFLYMYVCFASAV---YVPELWP 379
Cdd:cd17365 214 LLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLL---YVLVFLAGACVNGAQVGlyaLAARFYP 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1730619405 380 THLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIR-VFIVLGVMLVLCALILFC 434
Cdd:cd17365 291 TEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPEsVFLALAIPAALGALAVLL 346
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
54-435 |
1.46e-16 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 80.32 E-value: 1.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 54 SNNYLNATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYA 133
Cdd:cd17317 22 DRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 134 SFTEFIPPAVRgkwsarlsfvgnwspmlsAAIGVVVIAFLSWRMMFLLGGAamllawylsgkYFIESPRWLAgkgqrnaa 213
Cdd:cd17317 102 LGMEIVGPKYR------------------SFVGILFGLFWALGYMLLALLA-----------YLIRDWRWLQ-------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 214 ekhllqvelqiekeKSITLPpwqgagpaepcaesgSFWLLFKGQMLRRTLVAITVLIAMNISLYTITVWIPTIFvnSGID 293
Cdd:cd17317 145 --------------LAISLP---------------GLLFLLLLWWLPRRTIIVGLIWFVTSLVYYGLSLNSSNL--GGNL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 294 VTKSILMTAIIMIgapvGIFIAALIIDRFPRR--LFGSSLLMIIALLGYVYSIQTAEWAILSygLVMIFFLYMYVCFA-S 370
Cdd:cd17317 194 YLNFFLSGLVEIP----AYFLALLLLDRLGRRwtLSGSLLLAGLACLVTALLPDDENTLALT--LALVGKFAISAAFSvI 267
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1730619405 371 AVYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGValLLTRYGSIRVFIVLGVMLVLCALILFCF 435
Cdd:cd17317 268 YLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIV--LLGKIGPLLPLIIFGVLALLGGLLTLLL 330
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
62-440 |
2.52e-16 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 80.77 E-value: 2.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 62 FTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISA---CAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEF 138
Cdd:cd17357 54 IVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSllmFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEI 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 139 IPPAVRGKWSARLSFVGNWSPMLSAAIGV--VVIAFLSWRMMFLLGG---AAMLLAWYlsgkYFIESPRWLAG-KGQRNA 212
Cdd:cd17357 134 SPSELRGALGSLTQIGVTLGILLGQVFGLpsVLGTETLWPYLLFFPGipaLLQLAALP----FFPESPKFLLIsKGDEEE 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 213 AEKHL----------LQVELQIEKEKSitlppwqgagpAEPCAESGSFWLLFKGQMLR-RTLVAITVLIAMNISLYTITV 281
Cdd:cd17357 210 AEKSLkflrgieddvDQELEEIKKESE-----------QMGDQKQVSLMQLLRDPSLRlPLLLVLVVSASQQFSGINAIF 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 282 WIPT-IFVNSGIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR---LFGSSLLMIIALLGYVYSIQTAEWAILSYGLV 357
Cdd:cd17357 279 FYSTfIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRpllLISLSVCAVALLLMSVFLFLSEQNSWMSYGCI 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 358 MIFFLYMYvCFASAV------YVPELWPTHLR---LRGSGFVNAIGRIVAVFTpygvALLLTRYGSIRVFIVLGVMLVLC 428
Cdd:cd17357 359 VAIFLFIF-FFAIGLgpipwfIGAELFPQAPRsaaQSLGSSVNWTSNFIVGMA----FPPLQSIGGGFVFIIFAIPCALF 433
|
410
....*....|..
gi 1730619405 429 ALILFCFGIETR 440
Cdd:cd17357 434 LLYLYRYLPETK 445
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
63-433 |
1.56e-15 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 77.61 E-value: 1.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 63 TSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPA 142
Cdd:cd17319 44 ASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPAR 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 143 VRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAwylsgkyfiesprwlagkgqrnaaekhllqvel 222
Cdd:cd17319 124 ERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLL--------------------------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 223 qiekeksitlppwqgagpaepcaesGSFWLLFkgqmLRRTLVAITVLIAMNISLYTITVWIPTIFVNS-GIDVTKSILMT 301
Cdd:cd17319 171 -------------------------AVLWWFY----LRQVWGLALGYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 302 AIIMIGAPVGIFIAALIIDRFP----RRLFGSSLLMIIALLGYVYSIQTAEWAILsyGLVMIFFLYMYVCFASAVYVPEL 377
Cdd:cd17319 222 AIPFLAGAIGMILGGRLSDRLLrgarRLVIIIGLLLAAVGLLLAYLTTSPVVAVI--LLSLAGFGIGAASPVFWSLPADL 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1730619405 378 WPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIR-VFIVLGVMLVLCALILF 433
Cdd:cd17319 300 LPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTaAFLFLAAVALLAALLVL 356
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
72-434 |
9.13e-15 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 75.64 E-value: 9.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 72 IGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNM----YW----LIFFRCLMGCGM-----GALIMVgyasfTEF 138
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYaqigILapilLVLLRLLQGLALggewgGAVLMA-----VEH 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 139 IPPAVRGKWSArLSFVGNWSPMLSAAIGVVVI-------AFLS--WRMMFLLGGAAMLLAWYLSGKyFIESPRWLAGKGQ 209
Cdd:cd17369 134 APPKRRGFYGS-FPQLGAPVGLLLATGVFLLLsallsdeAFLSwgWRIPFLLSAVLVAVGLYIRLR-LEETPVFRRAKEA 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 210 RNAAEKHLLQVelqiekeksitlppWQGAGpaepcaesgsfwllfkgqmlRRTLVAITVLIAMNISLYTITVWIpTIFVN 289
Cdd:cd17369 212 GQVVRAPLVEV--------------LRRHW--------------------RALLLAIGLRLAENVLFYLFTTFA-LSYAT 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 290 SGIDVTKSIlMTAIIMIGAPVG---IFIAALIIDRFPRR--LFGSSLLMIIALLGYVYSIQTAEWAILSYGLVMIFFLYM 364
Cdd:cd17369 257 QTLGVDRST-VLLAVLIASVVAaitIPLFGWLSDRVGRRpvYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLH 335
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1730619405 365 YVCFAS-AVYVPELWPTHLRLRGSGFVNAIGRIVAV-FTPYGVALLLTRYGSIR-VFIVLGVMLVLCALILFC 434
Cdd:cd17369 336 GMMYGPqAAFLAELFPTRVRYTGASLGYQLGAILGGgFAPLIATALVAATGSWWpVALYLAALAVISLVAALF 408
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
17-192 |
2.32e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 73.31 E-value: 2.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 17 SRFHFRIFGIISFSLLITGFLSYSGNIVLAKLVSNGWSNNYLNATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLI 96
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 97 VGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWR 176
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170
....*....|....*.
gi 1730619405 177 MMFLLGGAAMLLAWYL 192
Cdd:COG0477 169 WIFLINAPLGLLALVL 184
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
63-436 |
4.82e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 73.37 E-value: 4.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 63 TSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVgyasftefIPPA 142
Cdd:COG2807 59 TTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVL--------LPGL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 143 VRGKWSARLSFV-------GNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAwylsgkyfiesprwlagkgqrnaaek 215
Cdd:COG2807 131 IKRWFPDRVGLMtglytaaMGLGAALAAGLTVPLAAALGWRGALAVWALLALLA-------------------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 216 hllqvelqiekeksitLPPWQGAGPAEPCAESGSFWLLFKGQMLRRTLV-AITVLIAMNISL-YTITVWIPTIFVNSGID 293
Cdd:COG2807 185 ----------------LLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAwLLTLFFGLQSLLyYAVVAWLPPILRDAGLS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 294 VTKSILMTAIIMIGAPVGIFIAALIIDRFPRR---LFGSSLLMIIALLGYVYSIQTAEW---AILSYGLVMIFFLYMyvc 367
Cdd:COG2807 249 AATAGLLLSLFQLAGIPGSLLVPLLADRLGDRrplLLLLGLLGLAGLLGLLLAPGSLPWlwaVLLGLGQGGLFPLAL--- 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1730619405 368 fasaVYVPELWPTHLRL-RGSGFVNAIGRIVAVFTPYGVALLLTRYGSIRV-FIVLGVMLVLCALILFCFG 436
Cdd:COG2807 326 ----TLIGLRARTPAEAaALSGMAQSVGYLLAALGPLLVGALHDATGSWTAaLLLLAALAVLMLVAGLLAG 392
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
55-438 |
8.57e-12 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 66.44 E-value: 8.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 55 NNYLNATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYAS 134
Cdd:cd17315 32 STSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 135 FTEFIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLSGKYFI-ESPRWLAGKGqrnaa 213
Cdd:cd17315 112 ISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFLpESRALLVGVG----- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 214 ekhlLQVELQIekeksitlppwqgagpaepcaeSGsfwllfkgqmlrrtlvaitvliaMNISLYtitvWIPTIFVNSGiD 293
Cdd:cd17315 187 ----LQLLQQL----------------------TG-----------------------INAVMY----YAPTIFKSAG-G 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 294 VTKSILMTAIIMIGAPVGIFIAALIIDRFPRR--LFGSSLLMIIALLGYVYSIQTAEWAILSYGLVMIFFLYMYVCFA-- 369
Cdd:cd17315 213 GTASILASIIVGVVNLLATLVAIRLVDKVGRRplLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAmg 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1730619405 370 ----SAVYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIRVFIVLGVMLVLCALILFCFGIE 438
Cdd:cd17315 293 agpvPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
60-432 |
9.34e-12 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 66.40 E-value: 9.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 60 ATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGAlIMVGYASFTEFI 139
Cdd:cd17372 37 ALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGG-GPQLASWYLEFL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 140 PPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLawylsgkyFIESPRWLAgkgqrnaaeKHLLQ 219
Cdd:cd17372 116 PAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSL--------LLVFYRWTP---------KTTLL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 220 VELQiekeksitlppWQGAgpaepcAESGSFWLLFKGQMLRRTLVAITVLIAMNISLYTitvwiPTIFVNSGIDVTKSIL 299
Cdd:cd17372 179 LWVI-----------WFGN------AFAYYGVVLLTTELNNSHNVCGSKSDSDSGESPT-----EKQCRNSNDVDYRDVF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 300 MTAiimIGAPVGIFIAALIIDRFPRRLFGSSLLMIIALLGYVYSIQTAEwailsygLVMIFFLYMYVCFASA------VY 373
Cdd:cd17372 237 IAT---FAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLLICQSP-------FILTVLLFGGRACISAaftvvyIY 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1730619405 374 VPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLL--TRYGSIRVFIVLGVMLVLCALIL 432
Cdd:cd17372 307 TPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLVhgSQTIALLLFSVVCLVSAICVCLL 367
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
27-433 |
1.04e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 66.30 E-value: 1.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 27 ISFSLLITGFLSYSGNIVLAKLVSNGWSNNYLNATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATF 106
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 107 VPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFL--SWRMMFLLgGA 184
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLI-AA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 185 AMLLAWYLSGKYFIESPRWLAGKGQRNAAEKHllqvelqiekeksitlppwqgagpaepcaesgSFWLLFKGQMLRRTLV 264
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSKS--------------------------------VLKLLKRVLKNPGLWL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 265 AITVLIAMNISLYTITVWIPTIFVNSGIDVTKSI-LMTAIIMIGAPVGIFIAALIIDRFPRR---LFGSSLLMIIALLGY 340
Cdd:cd06174 208 LLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAgLLLSLFGLAGALGSLLLGLLSDRLIGRkplLLIGLLLMALGLALL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 341 VYSIQTAEWAILSYGLVMIFFLYMYVCFAsavYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIR-VFI 419
Cdd:cd06174 288 LLAPSLLLLLLLLLLLGFGLGGLLPLSFA---LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTgAFL 364
|
410
....*....|....
gi 1730619405 420 VLGVMLVLCALILF 433
Cdd:cd06174 365 VLAVLLLLAAILLL 378
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
63-447 |
1.06e-11 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 66.12 E-value: 1.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 63 TSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISA---CAATfvPNMYWLIFFRCLMGCGMGALIMVGYASFTEFI 139
Cdd:cd17356 51 VSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAiiqVAAI--GKWYQLIVGRIIAGLGVGFASVLVPVYQSEVA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 140 PPAVRGkwsarlSFVGNWSpmLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLS---------GKYFI-ESPRWLagkgQ 209
Cdd:cd17356 129 PKHIRG------TLVSLYQ--LAITIGILVAYCINYGTHKLDGSAQWRIPLGLQivwglllliGMFFLpESPRWL----Y 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 210 RnaaekhllqvelqiekeksitlppwqgagpaepcaesgsFWLLFKGQMLRRtlvaitvLIAMNISLYtitvWIPTIFVN 289
Cdd:cd17356 197 R---------------------------------------TILGIMLQLFQQ-------LTGINYFFY----YGTTIFQS 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 290 SGIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR--LFGSSLLMIIALLGYVYSIQTAEWAIL-------SYGLVMIF 360
Cdd:cd17356 227 TGLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRtcLLIGAAGMSICLFIYAAVGVRYLIPNPqsgtsnkSAGNGMIV 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 361 FLYMYVCFASA-------VYVPELWPTHLRLRGSGFVNAI----GRIVAVFTPYGVALLltrygSIRVFIVLGVMLVLCA 429
Cdd:cd17356 307 FICLFIFSFATtwgpiawVYVAEVFPLRVRSKGMALATAFnwlwNFLISFFTPFIIGSI-----GFKYYYIFAGCNLLAF 381
|
410
....*....|....*...
gi 1730619405 430 LILFCFGIETRKVSLEEI 447
Cdd:cd17356 382 IVVFFFVPETKGLTLEEI 399
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
62-447 |
8.66e-11 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 63.53 E-value: 8.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 62 FTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPP 141
Cdd:cd17362 44 VVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPS 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 142 AVRGKWSARLSFVGNWSPMLSAAIGVVVI-AFLSWRMMFLLGGA-AMLLAWylsGKYFI-ESPRWlagkgqrnaaekhll 218
Cdd:cd17362 124 HIRGLLVSLKELFIVLGILLGYVSGYAFAdVVGGWRYMYGLAAPpALLLGI---GMWFLpPSPRW--------------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 219 qvelqiekeksitlppwqgagpaepcaesgsfwllfKGQMLRRTLVAITVLIAMNIS-LYTITVWIPTIFVNSGIdVTKS 297
Cdd:cd17362 186 ------------------------------------QGNYRKPLIIGLGLVLFQQITgQPSVLYYAATIFKSAGF-SAAS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 298 ILMTAIIMIGAPVGIF--IAALIIDRFPRR--LFGSSLLMIIAL--LGYVYSIQTAEWAILSYglVMIFFLYMYV-CFA- 369
Cdd:cd17362 229 DATLVSVGLGVFKLLMtiVAVLLVDKLGRRplLLGGVSGMVVSLflLAAYNLFVQMGPAGLAW--LSLVALLLYVgAYQi 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 370 -----SAVYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIRVFIVLGVMLVLCALILFCFGIETRKVSL 444
Cdd:cd17362 307 sfgpiSWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSL 386
|
...
gi 1730619405 445 EEI 447
Cdd:cd17362 387 EEI 389
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
64-192 |
1.24e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 62.98 E-value: 1.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 64 SALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAV 143
Cdd:cd17320 41 SAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAE 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1730619405 144 RGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMF--LLGGAAMLLAWYL 192
Cdd:cd17320 121 LAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFvfLALLGLLLLLLVL 171
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
54-440 |
1.48e-10 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 62.70 E-value: 1.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 54 SNNYLNATFTSALMF--GYF---IGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNM----YW----LIFFRCLM 120
Cdd:cd17367 32 SGDPTVALLSTAAVFavGFLmrpIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYatigIWapiiLLLARLLQ 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 121 GCGMGALIMVGYASFTEFIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLS--------WRMMFLLGGAAMLLAWYL 192
Cdd:cd17367 112 GLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLGedqmaawgWRIPFLLGGVLAVVVLWL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 193 sgkyfiesprwlagkgqRNAAEkhllqvelqiEKEKSITlppwqgagPAEPCAESGSFWLLFKGQMlRRTLVAITVLIAM 272
Cdd:cd17367 192 -----------------RRGLE----------ETESFEA--------IAESNEASAGTLRELRRHP-RELLLVVGLTAGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 273 NISLYTITVWIPTIFVNS-GIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRRlfgsSLLMIIALLGYVYSI------- 344
Cdd:cd17367 236 TLAFYTWTTYLQKFLVNTaGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRR----PLLLFFGIGGTLATVpllsald 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 345 -QTAEWAILSYGLVMIFFLYMYVCFaSAVYVPELWPTHLRLRGSGFVNAIGriVAVF---TPYgVALLLTRYGSIRVFIV 420
Cdd:cd17367 312 hTDSPYTAFALVLVGLVFLSGYTSI-NAVVKAELFPTHVRALGVGLPYALA--VAIFggtAPY-VALWLKSIGHEWVFFW 387
|
410 420
....*....|....*....|
gi 1730619405 421 LGVMLVLCALILFCFGIETR 440
Cdd:cd17367 388 YVAGLIAISLVVYLRMPETR 407
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
35-433 |
2.30e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 61.90 E-value: 2.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 35 GFLSYSGNIVLAKLVSNGWSNnylnATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRV---NLLIVGISACAATFVPNMY 111
Cdd:cd17355 17 GIRYYFGVFIIPIIAEFGWSR----AVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVmllGLLLLAAGLVLLALATSLW 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 112 WLIFFRCLMGCGM-GALIMVGYASFTEFIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAW 190
Cdd:cd17355 93 QLYLLWGLLGGGGaGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 191 YLSGKYFIESPRWLAGKGQRNAAEKHLLQVELQIekeksitlppwqgagpaepcAESGSFWLLFKGQmlrrtlvaITVLI 270
Cdd:cd17355 173 VPVLLLLRRRPADLALRAYDDASPASPGSTLKEA--------------------LRSASFWLLALAF--------FLCGF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 271 AMNIslytITVWIPTIFVNSGIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR--LFGSSLLMIIALLGYVYSIQTAE 348
Cdd:cd17355 225 AVVG----LIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRrlLAASYALRALGLALLLLLPFPPL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 349 WAILsYGLVMIFFLYMYVCFASAVYVpELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIR-VFIVLGVMLVL 427
Cdd:cd17355 301 ALLL-FAALFGLGWGATVPLTAALAA-RYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTaAWALAVALGLI 378
|
....*.
gi 1730619405 428 CALILF 433
Cdd:cd17355 379 AALLVL 384
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
17-433 |
7.16e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.64 E-value: 7.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 17 SRFHFRIFGIISFSLLITGFLSYSGNIVLAKLVSN-GWSNNYLnATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLL 95
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAfGLSDAQA-GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 96 IVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEfIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAF--- 172
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLgls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 173 LSWRMMFLLGGAAMLLAWYLSGKyfiesprwlagkgqrnaaekhllqvelqiekeksITLPPWQGAGPAEPCAESGSFWL 252
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLR----------------------------------SKLPEIEEEEEEAAGSAASLKSL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 253 LfkgqMLRRTLVAITVLIAMNISLYTITVWIPTIFVNS-GIDVTKSILMTAIIMIGAPVGIFIAALIIDRF-PRRLFGSS 330
Cdd:COG0738 207 L----KNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFgPVRLLRLS 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 331 LLMIIALLGYVYSIQTAEWAILSYGLVMIFFLYMYVCFASAvyVPELWPTHLRLRGSGFVnAIGRIVAVFTPYGVALLLT 410
Cdd:COG0738 283 ALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSL--ALDGLGKRTAAAVSAVL-IMGIVGGAIGPPLIGFLAD 359
|
410 420
....*....|....*....|...
gi 1730619405 411 RYGSIRVFIVLGVMLVLCALILF 433
Cdd:COG0738 360 AFGLRAAFLVPLVCYLLILLLAL 382
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
62-144 |
1.20e-09 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 59.67 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 62 FTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPP 141
Cdd:cd17379 38 FQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGS 117
|
...
gi 1730619405 142 AVR 144
Cdd:cd17379 118 KYR 120
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
64-433 |
1.98e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.10 E-value: 1.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 64 SALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAV 143
Cdd:cd17324 41 SAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 144 RGKWSARL---SFVGNwspMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLSGKYFiesprwlagkgqrnaaekhllqv 220
Cdd:cd17324 121 RGRAIGLVfsgLTLGL---VLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL----------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 221 elqiekeksitlpPWQGAGPAEPCAESGSFWLLFKGQMLRRTLVAITVLIAMNISLYTitvWIPTIFVN-SGIDVTKSIL 299
Cdd:cd17324 175 -------------PSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYT---YLAPFLTDvPGFSSSAIIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 300 MTAIIMIGAPVGIFIAALIIDRFPRR-LFGSSLLMIIALLGYVYSIQTAEWAILSYGLVMIFFLYMYVCFASAVYvpELW 378
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLADRGGRRaLLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVL--RLA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1730619405 379 PTHLRLRGSGFVNAIGRIVAVFTPYGvALLLTRYGSIRVFIVLGVMLVLCALILF 433
Cdd:cd17324 317 PEARGLASSLYLAAYNLGGALGAALG-GLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
72-436 |
5.53e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 5.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 72 IGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARL 151
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 152 SFVGNWSPMLSAAIGvVVIAFLSWRMMFLLGGAAMLLAwylsgkyfIESPRWLAGKGQRNAAEKHLLQVELQIEKEKSIt 231
Cdd:cd17473 130 SAAMSLGGVVFLLLG-GALAEIGWRAPFLVYLLALPVL--------ILVLLFLPEPARKSKSAASPGAATAAALPWKRV- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 232 lppwqgagpaepcaesgsfwllfkgqmlrrTLVAITVLIAMnISLYTITVWIPTIFVNSGIDVTKSI-LMTAIIMIGAPV 310
Cdd:cd17473 200 ------------------------------LPIYFLAFLAM-LLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGAI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 311 GIFIAALIIDRFPRR--LFGSSLLMIIALLGyvysiqtaewAILSYGLVMIFFLYMYVCFASAVYVP-------ELWPTH 381
Cdd:cd17473 249 GALLFGRLKRRLGKRrlLAIGFALMALGFLL----------LALASGLWVVLLGAILAGLGFGLLLPtlnswamSLVPPE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1730619405 382 LRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIR-VFIVLGVMLVLCALILFCFG 436
Cdd:cd17473 319 LRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSgAFLILGVLALVLAIVLLLLR 374
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
46-450 |
1.06e-08 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 57.01 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 46 AKLVSNGWSNNYLNATFTSALMfGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFV---------PNMYWLI-- 114
Cdd:PRK10077 45 PQNLSESAANSLLGFCVASALI-GCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALGSAWPefgftsigpDNTGYVPef 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 115 -FFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARLSFV----------GNWSPMLSAAIGVVVIafLSWRMMFllGG 183
Cdd:PRK10077 124 vIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAiifgqlvvyfVNYFIARSGDASWLNT--DGWRYMF--AS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 184 AAMLLAWYLSGKYFI-ESPRWLAGKGQRNAAEKHLLQVeLQIEKEKSITLPPWQGagpAEPCAESGSFWLLFkGQMLRRT 262
Cdd:PRK10077 200 EAIPALLFLMLLYFVpETPRYLMSRGKQEQAEGILRKI-MGNTLATQALQEIKHS---LDHGRKTGGKLLMF-GVGVIVI 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 263 LVAITVL---IAMNISLYtitvWIPTIFVNSGIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRRlfgssLLMIIALLG 339
Cdd:PRK10077 275 GVMLSVFqqfVGINVVLY----YAPEIFKTLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRK-----PLQIIGALG 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 340 Y---VYSIQTAEWAILSyGLVMIFFLYMYVCFASAVYVPELWPthlrLRGSGFVNAI-GRIVAV---------------F 400
Cdd:PRK10077 346 MaigMFSLGTAFYTQAP-GIVALLSMLFYVAAFAMSWGPVCWV----LLSEIFPNAIrGKALAIavaaqwianyfvswtF 420
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1730619405 401 TP-YGVALLLTRYGSIRVFIVLGVMLVLCALILFCFGIETRKVSLEEISSL 450
Cdd:PRK10077 421 PMmDKNSWLVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEMEAL 471
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
64-409 |
1.21e-08 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 56.89 E-value: 1.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 64 SALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAV 143
Cdd:PRK11551 57 SAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 144 RGK----WSARLSFVGnwspMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLSGKYFIESPRWLAGKGQRNAAekhllq 219
Cdd:PRK11551 137 RGTavslMYCGVPFGG----ALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQR------ 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 220 velqiekeksitlppwqgagpaepcaeSGSFWLLFKGQMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVTKSIL 299
Cdd:PRK11551 207 ---------------------------APVLRALFGEGRATATLLLWISYFFTLIVLYFLLNWLPSLLVGQGLSRSQAGL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 300 MTAIIMIGAPVGIFIAALIIDRFPRRLfgSSLLMIIALLGYVYSIQTAEwailSYGLVMI--FFLYMYVCFA-SAVY--V 374
Cdd:PRK11551 260 VQIAFNIGGALGSLLIGALMDRLRPRR--VVLLIYAGILASLAALAAAP----SFAGMLLagFAAGLFVVGGqSVLYalA 333
|
330 340 350
....*....|....*....|....*....|....*
gi 1730619405 375 PELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLL 409
Cdd:PRK11551 334 PLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLL 368
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
18-286 |
1.49e-08 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 56.91 E-value: 1.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 18 RFHFRIFGIISFSLLITGFLSYSGNIVLAKLVSNGWSNNYLNATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIV 97
Cdd:TIGR01299 163 RFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVN 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 98 GISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGK---WSARLSFVGNwspMLSAAIGVVVIAFLS 174
Cdd:TIGR01299 243 GFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEhlsWLCMFWMIGG---IYAAAMAWAIIPHYG 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 175 WRmmFLLGGAAMLLAWYL--------------SGKYFIESPRWLAGKGQRNAAEKHLLQVE------------------- 221
Cdd:TIGR01299 320 WS--FQMGSAYQFHSWRVfvivcafpcvfaigALTFMPESPRFFLENGKHDEAWMILKLIHdtnmrakghpekvfsvnhi 397
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1730619405 222 ---------LQIEKEKSITLPPWQGAGPAEPCAESGSFWLLFKGQMLRRTLVAITVLIAMNISLYTITVWIPTI 286
Cdd:TIGR01299 398 ktihqedelIEIESDTGTWYQRCFVRALSEGGGIWGNFLRCFNPEVREITIKLMGVWFTLSFGYYGLSVWFPDM 471
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
65-193 |
2.44e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 55.64 E-value: 2.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 65 ALMFGYFIgsLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVR 144
Cdd:cd17321 41 LLAFAALL--LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERR 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1730619405 145 GKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLS 193
Cdd:cd17321 119 GRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA 167
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
20-435 |
3.38e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 55.36 E-value: 3.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 20 HFRIFGIISFSLLITGFLSYSGNIVLAKLVSNGWSNNYLNATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGI 99
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 100 SACAATFVpnmYWLIFFRCLMGC-----GMGALIMVgyASFTEFIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLS 174
Cdd:cd17312 81 ANIFMGFS---TSLWFFAVLWGLnglfqSMGWPPCV--KLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 175 WRMMFLLGGAAMLLAWYLSGKYFIESPRWLagkgqrnaaekhllqvelqiekeksitlppwqgagpaepcaesgsfWLLf 254
Cdd:cd17312 156 WRAAFLVPGIVGLVVAIILFFFLRDSPPYV----------------------------------------------WVL- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 255 kgqmlrrtlvaITVLIAMNISLYTITVWIPTIFVNS-GIDVTKSILMTAIIMIGAPVGIFIAALIIDRF---PRRLFG-- 328
Cdd:cd17312 189 -----------SLAYAFVYIVRYACLDWGPLYLYEVkGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfggRRAPIAvi 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 329 SSLLMIIALLGYVYSIQTAEWAILSyGLVMIFFLYMYVCFASAVYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALL 408
Cdd:cd17312 258 YMLLMTLSLALFWFFPHNKLLSIVL-LFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYI 336
|
410 420
....*....|....*....|....*..
gi 1730619405 409 LTRYGSIRVFIVLGVMLVLCALILFCF 435
Cdd:cd17312 337 IDHYGWSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
64-433 |
4.85e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.89 E-value: 4.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 64 SALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAV 143
Cdd:cd17325 38 AAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 144 RGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLsgkyfiespRWLAGKGQRNAAEKHLLQVELQ 223
Cdd:cd17325 118 RGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVL---------ALLLLPEPRPPPNKRAVSAARL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 224 IEKEKSITLPPwqgagpaepcaesgSFWLLFkgqmlrrtLVAITVLIAMNISLYTITVWIPTIFvnsGIDVTKSILMTAI 303
Cdd:cd17325 189 RSGLRLLLRDR--------------RLLALF--------LAIFVLAFAFGALEPFLPLYAAELG---GLSPAQIGLLFGA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 304 IMIGAPVGIFIAALIIDRFPRRLFGSSLLMIIALLGYVYSIQTAEWAILSYGLVMIFFLYMYVcFASAVYVPELWPTHLR 383
Cdd:cd17325 244 QGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVF-PATLALLADIVPPEGR 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1730619405 384 LRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIRVFIVLGVMLVLCALILF 433
Cdd:cd17325 323 GTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
72-447 |
6.66e-08 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 54.33 E-value: 6.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 72 IGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGkwsARL 151
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRG---FLT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 152 SFvgnwsPMLSAAIG-----VVVIAF------LSWRMMFllgGAAMLLAWYLS-GKYFI-ESPRWlagkgqrNAAEKHLL 218
Cdd:cd17437 124 SF-----PEIFINIGillgyVSNYAFsglplhVGWRLML---GVGAVPSLFLAiGVLAMpESPRW-------TPAVRRML 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 219 QVELQIEkeksitlppwqgagpaepCAESGSfwllfkgqmlrrtlvaitvliamniSLYTITVWIPTIFVNSGIdVTKSI 298
Cdd:cd17437 189 IAALGIH------------------FFQQAS-------------------------GIDAVVLYSPRIFKKAGI-KSKDK 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 299 LMTAIIMIG--APVGIFIAALIIDRFPRR--LFGSSLLMIIAL--LGYVYSIQTAEWAILSYGLVM-IFFLYMYVCFASA 371
Cdd:cd17437 225 LLLATVAVGvtKTLFILVATFLLDKVGRRplLLTSTGGMTLSLtaLATSLTFIDRNGGGLTWALVLaITAVCSFVAFFSI 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 372 -------VYVPELWPTHLRLRGSGF---VNAIGRIVAVFTPYGVALLLTRYGsirVFIVLGVMLVLCALILFCFGIETRK 441
Cdd:cd17437 305 gagpitwVYSSEIFPLRLRAQGASLgvvVNRLMSGTVSMTFLSMSKAITTGG---TFFLFAGVAAAAWVFFYFFLPETKG 381
|
....*.
gi 1730619405 442 VSLEEI 447
Cdd:cd17437 382 KSLEEI 387
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
23-189 |
1.18e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.39 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 23 IFGIISFSLLITGFLSYSGNIVLAKLVSNGWSNNYLNATFTsalmFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISAC 102
Cdd:cd06173 214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFG----VGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 103 AATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLG 182
Cdd:cd06173 290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLA 369
|
....*..
gi 1730619405 183 GAAMLLA 189
Cdd:cd06173 370 GALLLLA 376
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
69-448 |
3.21e-07 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 52.42 E-value: 3.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 69 GYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPN------MYWLIFFRCLMGCGMGALIMVGYASFTEFIPPA 142
Cdd:TIGR00887 68 GTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGsspksvMATLCFWRFWLGVGIGGDYPLSAIITSEFATKK 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 143 VRGKW-SARLSFVG---------------------NWSPMLSAAIGVVVIAF-LSWRMMFLLGGAAMLLAWYLSGKyFIE 199
Cdd:TIGR00887 148 WRGAMmAAVFAMQGfgilagaivalivlagfkhslEAAADEASCTGSCVPAVdYMWRILIGFGAVPALLALYFRLT-IPE 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 200 SPRW--LAGKGQRNAAE--KHLLQVELQIEKEKSITlppwQGAGPAEPCAESGSFwllFKGQMLRRT----LVAITVLIA 271
Cdd:TIGR00887 227 TPRYtaDVAKDVEQAASdmSAVLQVKIEAEPDEVEK----ASTAVEVPKASWSDF---FTHFFKWRHgkhlLGTAGSWFL 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 272 MNISLYTITVWIPTIFVNSGIDVTKS------ILM------TAIIMIGAPVGIFIAALIID---RFPRRLFGsslLMIIA 336
Cdd:TIGR00887 300 LDIAFYGVNLNQKVILSAIGYSPPAAtnnayeELYktavgnLIIALAGTVPGYWVTVFLVDiigRKPIQLMG---FFILT 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 337 LLGYVYSIQTAEWAilSYGLVMIF-FLYMYVCF---ASAVYVP-ELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLT- 410
Cdd:TIGR00887 377 VLFFVLGFAYNHLS--THGFLAIYvLAQFFANFgpnATTFIVPgEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQh 454
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1730619405 411 ---RYGSIRVFIVLGVMLVLCAL----ILFCFGI-ETRKVSLEEIS 448
Cdd:TIGR00887 455 gdpTKGYPTGIWMGHVLEIFALFmflgILFTLLIpETKGKSLEELS 500
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
78-433 |
5.11e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.40 E-value: 5.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 78 GFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAvRGKWSARLSFVGNW 157
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 158 ----SPMLSAAIgVVVIAFLSWRMMFLLGGAAMLLAWYLSGKYFIESPRwlagkgqrnaaekhllqvelQIEKEKSITLP 233
Cdd:cd17478 131 gfalGPLIAAAL-VALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAK--------------------KAAAKSSARST 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 234 PWQGAGPaepcaesgsfwllfkgqmlrrtLVAITVLIAM-NISLYTITVWIPTIFVNSGIDVTKSILMTAIIMIGAPVGI 312
Cdd:cd17478 190 LKGVWRA----------------------LLLLLIIVFLrSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 313 FIAALIIDRFPRR--LFGSSLLMIIALLGYVYSIqtaewAILSYGLVMIFFLYMYVCF-ASAVYVPELWPTHLRLrGSGF 389
Cdd:cd17478 248 LIGGPLSDRFGRRrvIIASLLLAAPFLLLFLLTP-----GIWSYILLVLAGFLLFASFpVTVVLAQELLPGNVGL-ASGL 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1730619405 390 VNAIGRIVAVFTPYGVALLLTRYGSIRVFIVLGVMLVLCALILF 433
Cdd:cd17478 322 MMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
63-381 |
5.65e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.47 E-value: 5.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 63 TSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPA 142
Cdd:cd17328 40 QTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 143 VRGKWSARLSFVGNWSPMLSAAIG-VVVIAFLSWRMMFLLGGAAMLLAWYLSgKYFIESPRwlagkgqRNAAEkhllqve 221
Cdd:cd17328 120 KRTRALGVFYFAIPLGSGLGYVVGgLVAQATGGWRWAFRVTGVLGVLLAILL-LLFVREPP-------RGAAE------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 222 lqiekeksitlppwqgaGPAEPCAESGSFWLLFKGQMLRRTLVAITV-LIAMNISLYTITVWIPTiFVNSGIDVTK---- 296
Cdd:cd17328 185 -----------------GGVMAKSTATSFLADLKALAKNPSFILSTLgFTAVSFVTGALAFWAPT-FFLRAFGVGDlssa 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 297 --SILMTAIIMIGAPVGIFIAALIIDRFPRR------------LFGSSLLMIIALLGYVYSIQTAeWAILsygLVMIFFL 362
Cdd:cd17328 247 dvGLIFGAITCIAGVLGVLLGGILADRLRRKtpradplvcavgLLAAAPFLFLALVLALSNLLLA-WVLL---FLGEFLL 322
|
330
....*....|....*....
gi 1730619405 363 YMYVCFASAVYVPELWPTH 381
Cdd:cd17328 323 SLNWAPVFAILLYVVIPTR 341
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
72-409 |
7.23e-07 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 51.25 E-value: 7.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 72 IGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNM----YW--LIFFRCLMGCGM-------GALIMVGyasftEF 138
Cdd:PRK10642 72 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigIWapILLLLCKMAQGFsvggeytGASIFVA-----EY 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 139 IPPAVRGkwsarlsFVGNWSPMLSAA---IGVVVIAFLSWRMmfllgGAAMLLAWYLSGKYFIESPRWLAGKGQRNAAE- 214
Cdd:PRK10642 147 SPDRKRG-------FMGSWLDFGSIAgfvLGAGVVVLISTIV-----GEANFLDWGWRIPFFIALPLGIIGLYLRHALEe 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 215 -----KHLLQVELqiEKEKSITLPPwqgagpaepcaeSGSFWLLFKgQMLRRTLVAITVLIAMNISLYTITVWIPTIFV- 288
Cdd:PRK10642 215 tpafqQHVDKLEQ--GDREGLQDGP------------KVSFKEIAT-KHWRSLLTCIGLVIATNVTYYMLLTYMPSYLSh 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 289 NSGIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRRLF---GSSLLMIIALLGYVYsIQTAEWAILSYGLVMIFFLYMY 365
Cdd:PRK10642 280 NLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFvilGSVALFVLAIPAFIL-INSNVIGLIFAGLLMLAVILNC 358
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1730619405 366 VCFASAVYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLL 409
Cdd:PRK10642 359 FTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLV 402
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
63-431 |
9.22e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.67 E-value: 9.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 63 TSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPA 142
Cdd:cd17489 37 VGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPS 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 143 VRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLSgkYFIESPrwlagkgqrnaaekhllqvel 222
Cdd:cd17489 117 RRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV--FLVKDP--------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 223 qiekeksitlppwqgagPAEPCAESGSFWLLFKGQMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVTKSILM-T 301
Cdd:cd17489 174 -----------------PPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTvY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 302 AIIMIGAPvgiFIAALIIDRFPRRLFGSSLLMIIAlLGYVYSIQTAEWAILSYGLVMIFFLYMYVCFASAVYVPELWPTH 381
Cdd:cd17489 237 AIALLLSR---PFSGKLSDRKGPKTVIIPGLLLLA-LGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPH 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1730619405 382 LRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIRVFIVLGVMLVLCALI 431
Cdd:cd17489 313 RRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
68-284 |
1.13e-06 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 50.69 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 68 FGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKW 147
Cdd:cd17438 45 LGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEH 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 148 SARLSFVGNWSPMLSAAIGVVVIA-------------FLSWRmMFLLGGAAMLLAWYLSGKYFIESPRWLAGKGQRNAAE 214
Cdd:cd17438 125 LSWLCMFWMIGGLYASAMAWSIIPhygwgfsmgtnyhFHSWR-VFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAW 203
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1730619405 215 KHLLQVELQIEKEKsitlppwqgagpaepcaesGSFWLLFKGQMLRR--TLVAITVLIAMNISLYTITVWIP 284
Cdd:cd17438 204 MILKNIHDTNMRAK-------------------GTPEKVFTVSNIKRknTLFLAVVWFTMAFSYYGLTVWFP 256
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
82-191 |
1.22e-06 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 50.32 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 82 DYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARLSFVGNWSPML 161
Cdd:PRK15402 73 DRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLL 152
|
90 100 110
....*....|....*....|....*....|
gi 1730619405 162 SAAIGVVVIAFLSWRMMFLLGGAAMLLAWY 191
Cdd:PRK15402 153 GPLVGAALIHVLPWRGMFVLFAALAALSFF 182
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
60-434 |
1.63e-06 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 49.96 E-value: 1.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 60 ATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFI 139
Cdd:cd17360 38 ELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 140 PPAVRGKWSARLSFVGNWSPMLSAAI-GVVVIAFLSWRMMFLLGGAAMLLawYLSGKYFI-ESPRWlagkgqrnaaekhl 217
Cdd:cd17360 118 PPRIRGRLVTINVLFITGGQFVAYVInGAFSYLPGGWRWMLGLAAVPAVL--QFIGLLFLpESPRW-------------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 218 lqvelqiekeksitlPPwqgagpaepcaesgsfwllfkgqMLRRTLVAITVLIAMNIS-LYTITVWIPTIFVNSGIDVTK 296
Cdd:cd17360 182 ---------------PS-----------------------TRRALIVGCGLQAFQQFSgINTVMYYSATILQMAGFKDNQ 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 297 SILMTAIIMIGAP-VGIFIAALIIDRFPRR--LFGSSLLMIIALLgyvysiqtaewaILSYGLVMIFFLYMYVCFASA-- 371
Cdd:cd17360 224 NAIWLSLIVAGTNfIFTIVGMYLIDKFGRRklLLISLFGVIVALV------------VLAVWLALVGLILYLAFFAPGmg 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 372 ----VYVPELWPTHLRLRGSGF---VNAIGRIVAVFTPYGVALLLTRYGSIrvFIVLGVMLVLCALILFC 434
Cdd:cd17360 292 pvpwTVNSEIYPLWARGTGGGCaaaVNWVFNLLVSQTFLTLTQAIGPYGTF--LLFAGLAVLGLIFIYFC 359
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
68-284 |
1.72e-06 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 50.03 E-value: 1.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 68 FGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKW 147
Cdd:cd17439 45 LGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEH 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 148 SARLSFVGNWSPMLSAAIGVVVIAFLSWRmmFLLGGAAMLLAWYL--------------SGKYFIESPRWLAGKGQRNAA 213
Cdd:cd17439 125 LSWLCMFWMIGGIYASAMAWAIIPHYGWS--FQMGSAYQFHSWRVfvlvcafpsvfaigALTTMPESPRFFLENGKHDEA 202
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1730619405 214 EKHLLQVELQIEKEKsitlppwqgagpaepcaesGSFWLLFKGQMLRR--TLVAITVLIAMNISLYTITVWIP 284
Cdd:cd17439 203 WMVLKQVHDTNMRAK-------------------GHPERVFSVTHIKRriTLMMMAVWFTMSFSYYGLTVWFP 256
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
72-190 |
1.85e-06 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 50.07 E-value: 1.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 72 IGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARL 151
Cdd:TIGR00711 52 ISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIW 131
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1730619405 152 SFVGNWSPMLSAAIGVVVIAFLSWRMMFLL----GGAAMLLAW 190
Cdd:TIGR00711 132 GLTVLVAPALGPTLGGWIIENYHWRWIFLInvpiGIIVVVVAF 174
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
60-178 |
3.96e-06 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 48.65 E-value: 3.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 60 ATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMvGYASFTEFI 139
Cdd:cd17442 39 ALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGCGVSGHSQ-GLIIKTEFL 117
|
90 100 110
....*....|....*....|....*....|....*....
gi 1730619405 140 PPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMM 178
Cdd:cd17442 118 PTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWL 156
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
256-413 |
6.02e-06 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 48.12 E-value: 6.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 256 GQMLRRT-LVAITVLIAMNISLYTITVWIPTIFVNS-GIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR---LFGSS 330
Cdd:cd17366 188 GLYLRRPlLICIGLVLVFNVTNYMLLSYMPSYLEETlGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKpvyAAGLA 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 331 LLMIIALLGYVYSIQTAEWAILSYGLVMIFFLYMYVCFASAVyVPELWPTHLRLRGSGFVNAIGriVAVF---TPYGVAL 407
Cdd:cd17366 268 GLLVLAVPAFLLMNSGSIAAIFIGLLVLGLLLSCYTATMAST-LPALFPTHVRYSALAIAFNIS--VSLFggtTPLVASW 344
|
....*.
gi 1730619405 408 LLTRYG 413
Cdd:cd17366 345 LVSATG 350
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
60-433 |
7.39e-06 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 48.16 E-value: 7.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 60 ATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNmYWLIF-FRCLMGCGMGALIMVGYASFTEF 138
Cdd:PRK03893 58 ASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPG-YWTLFiARLVIGMGMAGEYGSSATYVIES 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 139 IPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLsgkyfiesprwlagkgQRNAAEKHLL 218
Cdd:PRK03893 137 WPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWL----------------RKNLPEAEDW 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 219 QvELQIEKEKSITLppwqgagpaepcaesgsFWLLFKGqmlRRTLVAITVLIAMNISLYTITvwipTIFVNSGIDVTKSI 298
Cdd:PRK03893 201 K-EKHAGKAPVRTM-----------------VDILYRG---EHRIINILLTLAAAAALWFCF----AGNLQNAAIVAVLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 299 LMTAIIMIgapvgifiaALIIDRFPRRLFGSSLLMIIALLGYVYSiqtaeWAILSyglvmifflymyvcfasavyvpeLW 378
Cdd:PRK03893 256 LLCAAIFI---------SFMVQSSGKRWPTGVMLMVVVLFAFLYS-----WPIQA-----------------------LL 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1730619405 379 PTHLR-------------LRGSGFVNAIGRIVAVFT--------PYGVALLLTRYGSIRVFIVLGVMLVLCALILF 433
Cdd:PRK03893 299 PTYLKtdlgydphtvanvLFFSGFGAAVGCCVGGFLgdwlgtrkAYVCSLLISQLLIIPVFAIGGANVWVLGLLLF 374
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
78-181 |
1.04e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 47.17 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 78 GFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARLSFVGNW 157
Cdd:cd17502 51 GKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGI 130
|
90 100
....*....|....*....|....
gi 1730619405 158 SPMLSAAIGVVVIAFLSWRMMFLL 181
Cdd:cd17502 131 ASVAGPLIGGAFTDHLSWRWCFYI 154
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
64-189 |
1.14e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 47.38 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 64 SALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAV 143
Cdd:TIGR00710 47 TLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEE 126
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1730619405 144 RGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLA 189
Cdd:TIGR00710 127 LSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILL 172
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
78-181 |
1.70e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.80 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 78 GFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARLSFVGNW 157
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILL 131
|
90 100
....*....|....*....|....
gi 1730619405 158 SPMLSAAIGVVVIAFLSWRMMFLL 181
Cdd:cd17503 132 APAIGPTLGGWLTDNLSWRWIFYI 155
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
54-126 |
2.26e-05 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 46.50 E-value: 2.26e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1730619405 54 SNNYLNATFTSALMfGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPN------MYWLIFFRCLMGCGMGA 126
Cdd:cd17364 37 PSGVSGLVNAAALV-GTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLGIGIGG 114
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
69-284 |
2.32e-05 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 46.71 E-value: 2.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 69 GYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWS 148
Cdd:cd17363 46 GMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 149 ARLSFVGNWSPMLSAAIGVVVIA-------------FLSWRmMFLLGGAAMLLAWYLSGKYFIESPRWLAGKGQRNAAEK 215
Cdd:cd17363 126 SWLCMFWMIGGLYASAMAWAIIPhygwgfsmgtayqFHSWR-VFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWM 204
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1730619405 216 HLLQVELQiekeksitlpPWQGAGPAEPcaesgsfwlLFKGQMLRR--TLVAITVLIAMNISLYTITVWIP 284
Cdd:cd17363 205 ILKQVHDT----------NMRAKGHPER---------VFTVSHIKRmnTLFLAIVWFTMSFSYYGLTVWFP 256
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
64-434 |
3.09e-05 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 45.81 E-value: 3.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 64 SALMFGYFIGSLT-GGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPA 142
Cdd:cd17378 40 SSFFVGCLIGSGVlGHLADSSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 143 VRGKwsarlsfvgnwspmlsaaigVVVIAFLswrmMFLLGGAAmllawyLSGKYFIESPRWlagkgqrnaaeKHLLQVel 222
Cdd:cd17378 120 WRGQ--------------------VGMSTFF----FFVLGFMS------LPGIAYLNGSSW-----------RVLYFW-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 223 qiekeksITLPPwqgagpaepcaesgSFWLLFKGQMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVTksilMTA 302
Cdd:cd17378 157 -------TSIPA--------------LIYCILVYLFARRLLAVMVIGFGIGMVYYGIPLAVGNLKFNIYLSVA----LNA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 303 IIMIGApvgIFIAALIIDRFPRR--LFGSSLLMIIA-LLGYVYSIQTAEWAILSYGLVMIFflymyvCFASA-----VYV 374
Cdd:cd17378 212 LSELPA---FVITAFLLDRFGRRpsLLGFTLLSGAScLLCFVLSIGGTTSLQIALELVGFF------GAAGAfnllyIYT 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 375 PELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALllTRYGSIRVFIVLGVMLVLCALILFC 434
Cdd:cd17378 283 VELFPTCVRNAALGMLRQALVVGGIFAPFIVSL--GRKNAALSFGVFGVAILLLGLFALG 340
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
63-193 |
4.74e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 45.26 E-value: 4.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 63 TSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPA 142
Cdd:cd17323 40 VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPE 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1730619405 143 VRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLS 193
Cdd:cd17323 120 ERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILI 170
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
58-433 |
6.55e-05 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 44.97 E-value: 6.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 58 LNATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTE 137
Cdd:cd17374 36 LKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 138 FIPPAVRgkwsarlsfvgnwspmlsAAIGVVVIAFLSWRMMfLLGGAAMLLawylsgkyfiesPRWlagkgqrnaaekHL 217
Cdd:cd17374 116 WTTPRHR------------------ALAITLTSCFFSIGQM-LLAGLAYAI------------RDW------------RL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 218 LQVelqiekekSITLPpwqgagpaepcaesGSFWLLFKGQMLRRTLVAITVLIAMNISLYTITVWIPTIfvnsGIDVTKS 297
Cdd:cd17374 153 LQL--------VVSVP--------------FFLFFLYSWWLPKRTLILSFVWFANSFSYYGLSLDLQHL----GLNVFLL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 298 ILMTAIIMIGAPvgiFIAALIIDRFPRR--------LFGSSLLMIIALLGYVYSIQTAeWAILSYGLVMIFFLYMYvcfa 369
Cdd:cd17374 207 QFLFGAVEVPAR---CLALFLLNHMGRRisqavlllLAGLCILANIFVPQEMQTLRTV-LAVLGKGSSAAAFTISY---- 278
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1730619405 370 saVYVPELWPTHLRLRGSGFVNAIGRIVAVFTPygVALLLTRYGSIRVFIVLGVMLVLCALILF 433
Cdd:cd17374 279 --VYTAELFPTVLRQTGMGLNSMFARIGGILAP--LIMLLGVYSPLLPMIIYGVLPILAGLLAL 338
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
259-435 |
6.77e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 6.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 259 LRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR--LFGSSLLMIIA 336
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRrvLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 337 LLGYVYSiQTAEWAILSYGLVMIFFLYMYVcfASAVYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIR 416
Cdd:COG2814 89 SLLCALA-PSLWLLLAARFLQGLGAGALFP--AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170
....*....|....*....
gi 1730619405 417 VFIVLGVMLVLCALILFCF 435
Cdd:COG2814 166 VFLVNAVLALLALLLLLRL 184
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
78-435 |
8.03e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.48 E-value: 8.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 78 GFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGK----WSARLSF 153
Cdd:cd17474 55 GVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKamglYEAALGL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 154 VGNWSPMLSAAIGVVviaflSWRMMFLLGGAAMLLAWYLSGKYFIESPRwlagKGQRNAAEKHLLQVELQiekeksitlp 233
Cdd:cd17474 135 GIAVGPLLGGLLAAI-----SWRYPFFLLAALIPVAFLAILFLLPEPKE----KAKSSSATKLRDLKKAL---------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 234 pwqgagpaepcaesgsfwllfkgqmLRRTLVAITVLIAM-NISLYTITVWIPTIFVNS-GIDVTKSILMTAIIMIGAPVG 311
Cdd:cd17474 196 -------------------------RGRGLLTFLVSAFLyFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLLALG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 312 IFIAALIIDRFprrlFGSSLLMIIALLGYVYSIqTAEWAILSYGLVMIFFLYMYVCFASAV-----YVPELWPTHLRLRG 386
Cdd:cd17474 251 SLFVGRLLKKR----FGARRILVIGLLLYALSL-LLLGFVPSLALLLIAIVLFGLGLGLNLpllttLVTELAPEEERGTA 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1730619405 387 SGFVNAIGRIVAVFTPYGVALLLTRYGSIRVFIVLGVMLVLCALILFCF 435
Cdd:cd17474 326 SSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
60-432 |
1.10e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.09 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 60 ATFTSALMFGYFIGSLTGGFMGDYL----GRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASF 135
Cdd:cd17477 30 TALIGLVASAYYLGILLGSPLVPRLirrvGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 136 TEFIPPAVRGKWSARLSFVGnwspMLSAAIGVVVIAFLSWR--MMFLLGGAAMLLAWylsgkyfiesprwlagkgqrnaa 213
Cdd:cd17477 110 NALATNENRGRVLGLYSTVL----GLGFALGPLLLALVGTAgaLPFLIAAVLLLLAL----------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 214 ekhllqvelqiekeksITLPPWQGAGPAEPCAESGSFWLLFKgqMLRRTLVAITVLIAMNISLYTItvwIPTIFVNSGID 293
Cdd:cd17477 163 ----------------VPLLLTRRAAPEIEEAESISLRRLLR--IAPLALLGAFVAGFLEGAFYSL---LPLYGLRLGLS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 294 VTKSILMTAIIMIGAPVGIFIAALIIDRFPRR--LFGSSLLMIIALLGYvysiqtaeWAILSYGLVMIFFLYMYVCFASA 371
Cdd:cd17477 222 VAQAALLLAAFVLGGLLLQWPLGWLADRFDRRrvLLGCALLGALAALLL--------PLVPGLPLALLVLLFLWGGAAGP 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1730619405 372 VYVPELWPTHLRLRGSGFVNAIGRIVAVFT------PYGVALLLTRYGSIRVFIVLGVMLVLCALIL 432
Cdd:cd17477 294 LYTLALALAGDRLPGDELVAANAALLLLYGlgsvigPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
68-432 |
1.42e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.76 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 68 FGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKW 147
Cdd:cd17329 46 VAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 148 SARLSFVGNWSPMLSAAIGVVVIAFlSWRMMFLLGGAAMLLawylsgkYFIesprWLAgkgqrnaaekhllqvelqieke 227
Cdd:cd17329 126 FSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLL-------AAL----VLL---------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 228 ksITLPPWQGAGPAEPCAESGSFWLLFKGQMLRRTLVAITVLIAMniSLYTITVWIPTIFVNSGIDVTKsilMTAIIMIG 307
Cdd:cd17329 172 --FLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISL--IYFQLESTLPVYVVEILGLGES---LLGLLLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 308 APVGIFIAALIIDRFPRRlFGSSLLMIIALLGYVYSIQTAEWAILSYGLVMIFFLY----MYVCFASAVYVPELWPTHLR 383
Cdd:cd17329 245 NALLIVLLQFPVARLVER-FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLtlgeMLVFPAVQTLVAALAPPDKR 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1730619405 384 LRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIRVFIVLGVMLVLCALIL 432
Cdd:cd17329 324 GSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALL 372
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
60-193 |
1.44e-04 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 44.03 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 60 ATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGAlIMVGYASFTEFI 139
Cdd:cd17441 37 ALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGG-VPQSVTLYAEFL 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1730619405 140 PPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLS 193
Cdd:cd17441 116 PMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLIFAVLC 169
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
60-435 |
1.64e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.76 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 60 ATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVN-----LLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYAS 134
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 135 FTEFIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLSgkYFIESPRwlagkgqrnaae 214
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLL--LFIRRPP------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 215 khllqvelqiekeksitlPPWQGAGPAEPCAESGSFWLLFKGQMLRRTLVAITVLIAMNISLYTITVwIPTIFVNSGIDV 294
Cdd:cd06173 183 ------------------PAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLL-PLLAKEVLGGGA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 295 TKSILMTAIIMIGAPVGIFIAALIIDRFPRR--LFGSSLLMIIALLGYVYSIQTAEWAILsygLVMIFFLYMYVCFASAV 372
Cdd:cd06173 244 AGYGLLLAAFGVGALLGALLLGRLSKRRRRGrlLLIGALLLGLALLVLGLSPSLWLLLAA---LFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1730619405 373 YVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIRVFIVLGVMLVLCALILFCF 435
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
58-193 |
1.97e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 43.34 E-value: 1.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 58 LNATFTSALMFGYFIGSLtggfmGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMvGYASFTE 137
Cdd:cd17504 37 LTAYLLVGAVSTPILGRL-----GDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPL-AFALVRE 110
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1730619405 138 FIPPAVRGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLS 193
Cdd:cd17504 111 EFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV 166
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
78-202 |
2.00e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 43.36 E-value: 2.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 78 GFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMgcGMGALIMVGYASFTEFIPPAVRGKWSARLSFVGNW 157
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQ--GSGAISSVVMALLADLTREENRTKAMALIGASIGI 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1730619405 158 SPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLSGKYFIESPR 202
Cdd:cd17472 131 AFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPK 175
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
64-144 |
2.13e-04 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 43.17 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 64 SALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAV 143
Cdd:cd17446 40 SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRV 119
|
.
gi 1730619405 144 R 144
Cdd:cd17446 120 R 120
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
264-433 |
3.33e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 3.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 264 VAITVLIAMNISLYTITVWIPTIFVNSGIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRRLFGSSLLMIIALLGYVYS 343
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 344 IQTAEWAILSYGLVMIFFLYMYVCfASAVYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIRVFIVLGV 423
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFP-AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170
....*....|
gi 1730619405 424 MLVLCALILF 433
Cdd:pfam07690 160 LSLLAAVLLL 169
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
62-432 |
5.12e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.23 E-value: 5.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 62 FTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPP 141
Cdd:cd17475 36 LLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 142 AVRG-KWSARLSFVgNWSPMLSAAIGVVVIAFLSWRMMFLLGGAAMLLAWYLSGKYFIESPrwlagkgqrnaaekhllqv 220
Cdd:cd17475 116 RERGlAMGIRQTGV-PLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPP------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 221 elqiekeksitlppwqgaGPAEPCAESGSFWLLFKGQMLRRTLVAITVLIAMNISLYTITVWIPTIFVNS--GIDVTKSI 298
Cdd:cd17475 176 ------------------AASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDhlGLSVVAAG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 299 LMTAIIMIGAPVGIFIAALIIDRFP--RRLFGSSLLMIIALLGYVySIQTAEWAILSYGLVMIFFLYMYVCFA----SAV 372
Cdd:cd17475 238 ALLAVAQLGGALGRIGLGRVSDRVFggRRRPVLVITAAIAAAALL-VLSLLSPGTPLWLLVLLLILLGLFAIGwnglYLT 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1730619405 373 YVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGVALLLTRYGSIR-VFIVLGVMLVLCALIL 432
Cdd:cd17475 317 LVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYApAWLALALLLVLAALLL 377
|
|
| MFS_SLC22A4_5_OCTN1_2 |
cd17376 |
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ... |
38-435 |
1.03e-03 |
|
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340934 [Multi-domain] Cd Length: 342 Bit Score: 40.91 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 38 SYSGNIVLAKLVSNgWS----NNYLNATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNmyWL 113
Cdd:cd17376 13 EYSQDVYLSTIVTE-WNlvceDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPS--WE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 114 IFFRCLMGCGMG--ALIMVGYASFTEFIPPAVRgkwsarlsfvgnwspMLSAAIGVVviaflswrMMFLLGgaAMLLAWY 191
Cdd:cd17376 90 MFTVLFVIVGMGqiSNYVVAFVLGTEILGKSVR---------------ILFSTLGVC--------IFYAIG--YMLLPLF 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 192 lsgKYFIESPRWLAgkgqrnaaekhllqveLQIEKEKSITLPPWqgagpaepcaesgsfWLLfkgqmLRRTLVAITVLIA 271
Cdd:cd17376 145 ---AYFIRDWRMLL----------------LALTLPGVLCVPLW---------------WFI-----PITTIMSLLLWMA 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 272 MNISLYTITVWIPtifvNSGIDVTKSILMTAIIMIGAPVgifIAALIIDRFPRRLFGSSLLMIIALLGYVYSIQTAEWAI 351
Cdd:cd17376 186 ISVGYFGLSLNTP----NLHGDPYLNCFLSAVIEVPAYI---IAWLLLRSLPRRYSIAATLVLGGGVLLFIQLVPTDLQV 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 352 LSYGLVMIFFLYMYVCFASA-VYVPELWPTHLRLRGSGFVNAIGRIVAVFTPYGValLLTRYGSIRVFIVLGVMLVLCAL 430
Cdd:cd17376 259 LATALVMLGKFGITAAFSMVyVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFV--YLGAYDRYLPYILMGSLTVLIGI 336
|
....*
gi 1730619405 431 ILFCF 435
Cdd:cd17376 337 LTLFL 341
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
23-189 |
1.08e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.02 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 23 IFGIISFSLLITGFLSYSGNIVLAKLVSNGWSNNYLNATFTSALMFG-YFIGSLTGGFmgdyLGRRKAFRVNLLIVGISA 101
Cdd:cd17474 204 LVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGsLFVGRLLKKR----FGARRILVIGLLLYALSL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 102 CAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAVRGKWSARLSFVGNwspmLSAAIGVVVIAFL----SWRM 177
Cdd:cd17474 280 LLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRF----LGQAVGPLLFGLLleifGLSA 355
|
170
....*....|..
gi 1730619405 178 MFLLGGAAMLLA 189
Cdd:cd17474 356 PFLVGAAIALAA 367
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
64-220 |
4.23e-03 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 39.51 E-value: 4.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 64 SALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGISACAATFVPNMYWLIFFRCLMGCGMGALIMVGYASFTEFIPPAV 143
Cdd:cd17440 41 SIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 144 RGKWSARLSFVGNWSPMLSAAIGVVVIAFLSWrmMFLLGGAAMLLAW--------------YLSGKYFIESPRWLAGKGQ 209
Cdd:cd17440 121 RGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW--SFSMGSAYQFHSWrvfvivcalpcvssVVALTFMPESPRFLLEVGK 198
|
170
....*....|.
gi 1730619405 210 RNAAEKHLLQV 220
Cdd:cd17440 199 HDEAWMILKQI 209
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
21-140 |
5.75e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 38.73 E-value: 5.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730619405 21 FRIFGIISFSLLITGFLSYSGNIVLAKLVSNGwsNNYLNATFTSALMFGYFIGSLTGGFMGDYLGRRKAFRVNLLIVGIS 100
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFKYVLGL--SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1730619405 101 ACAATFVP--NMYWLIFFRCLMGCGMGALIMVGYASFTEFIP 140
Cdd:COG2211 308 LLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVD 349
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
277-437 |
8.46e-03 |
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2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 38.33 E-value: 8.46e-03
10 20 30 40 50 60 70 80
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gi 1730619405 277 YTITVWIPTIFVNSGIDVTKSILMTAIIMIGAPVGIFIAALIIDRFPRR---LFGSSLLMIIALLGYVYSiqtaeWAILS 353
Cdd:cd17339 213 YTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILATRLKNQrpiVVLLAVLFIIGVLGLLFA-----PTALA 287
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90 100 110 120 130 140 150 160
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gi 1730619405 354 YGLVMIFFLYMYVCFASAVYVPELWPTHLRLRG--SGFVNAIGRIVAVFTPYGVALLLTRYGSIRVFIVLgvmLVLCALI 431
Cdd:cd17339 288 LLWAVLLGLGGGAAFSLALTLISLRSSDPAEAAalSGMAQSVGYLLAALGPLLFGVLHDLTGSWTAPLVL---LLALTVL 364
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....*.
gi 1730619405 432 LFCFGI 437
Cdd:cd17339 365 QLVAGL 370
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