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Conserved domains on  [gi|2090923489|gb|UAD16531|]
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universal stress protein UspE [Klebsiella quasipneumoniae]

Protein Classification

universal stress protein UspE( domain architecture ID 11485249)

universal stress protein UspE is a tandem-type universal stress protein (USP) that consists of two Usp domains and is required for resistance to DNA-damaging agents; enhances the rate of cell survival during prolonged exposure to stress agents

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11175 PRK11175
universal stress protein UspE; Provisional
 2-306 0e+00

universal stress protein UspE; Provisional


:

Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 642.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489   2 AKYQSMLVVIDPNQDDQPALRRAVYLHQRIGGRIKAFLPIYDFSYEMTTLLSPDERTAMRQGVIAQRTAWIREQAKFYLE 81
Cdd:PRK11175    1 AKYQNILVVIDPNQDDQPALRRAVYLAQRNGGKITAFLPIYDFSYEMTTLLSPDEREAMRQGVISQRTAWIREQAKPYLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489  82 SGVPIDVKVVWHNRPFEAIIQEVISEKHDLLLKMAHQHDKLEAVIFTPTDWHLLRKCPCPVWMVKDQPWPEGGKALVAVN 161
Cdd:PRK11175   81 AGIPIEIKVVWHNRPFEAIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQDWPEGGKILVAVN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489 162 LASEENYHNTLNEKLVRETLSLAEEVNHTEVHLIGAYPVTPINIAIELPDFDPSVYNDAIRGQHLLAMKALRQKFGIDEK 241
Cdd:PRK11175  161 VASEEPYHDALNEKLVEEAIDLAEQLNHAEVHLVNAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGIDEE 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2090923489 242 FTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGLSAAFLGNTAEQVVDHLRCDLLVLKPEAYQT 306
Cdd:PRK11175  241 QTHVEEGLPEEVIPDLAEHLDAELVILGTVGRTGLSAAFLGNTAEHVIDHLNCDLLAIKPDGYVS 305
 
Name Accession Description Interval E-value
PRK11175 PRK11175
universal stress protein UspE; Provisional
 2-306 0e+00

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 642.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489   2 AKYQSMLVVIDPNQDDQPALRRAVYLHQRIGGRIKAFLPIYDFSYEMTTLLSPDERTAMRQGVIAQRTAWIREQAKFYLE 81
Cdd:PRK11175    1 AKYQNILVVIDPNQDDQPALRRAVYLAQRNGGKITAFLPIYDFSYEMTTLLSPDEREAMRQGVISQRTAWIREQAKPYLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489  82 SGVPIDVKVVWHNRPFEAIIQEVISEKHDLLLKMAHQHDKLEAVIFTPTDWHLLRKCPCPVWMVKDQPWPEGGKALVAVN 161
Cdd:PRK11175   81 AGIPIEIKVVWHNRPFEAIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQDWPEGGKILVAVN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489 162 LASEENYHNTLNEKLVRETLSLAEEVNHTEVHLIGAYPVTPINIAIELPDFDPSVYNDAIRGQHLLAMKALRQKFGIDEK 241
Cdd:PRK11175  161 VASEEPYHDALNEKLVEEAIDLAEQLNHAEVHLVNAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGIDEE 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2090923489 242 FTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGLSAAFLGNTAEQVVDHLRCDLLVLKPEAYQT 306
Cdd:PRK11175  241 QTHVEEGLPEEVIPDLAEHLDAELVILGTVGRTGLSAAFLGNTAEHVIDHLNCDLLAIKPDGYVS 305
USP-E_repeat1 cd23943
Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP ...
 4-146 3.44e-97

Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467508  Cd Length: 143  Bit Score: 282.90  E-value: 3.44e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489   4 YQSMLVVIDPNQDDQPALRRAVYLHQRIGGRIKAFLPIYDFSYEMTTLLSPDERTAMRQGVIAQRTAWIREQAKFYLESG 83
Cdd:cd23943     1 YQNMLVVIDPNQDDQPALRRAVYLVQRIGGKIKAFLPIYDLSYEMTTLLSPDERTAMRQGVISQRTAWIREQAKYYLEAG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2090923489  84 VPIDVKVVWHNRPFEAIIQEVISEKHDLLLKMAHQHDKLEAVIFTPTDWHLLRKCPCPVWMVK 146
Cdd:cd23943    81 IPIEIKVVWHNRPFEAIIQEVIAGNHDLVLKMAHQHDRLESLIFTPTDWHLLRKCPSPVWMVK 143
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 7-146 1.82e-19

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 82.84  E-value: 1.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489   7 MLVVIDPNQDDQPALRRAVYLHQRIGGRIKAFLPIYDFSYEMTTLLSPDERTAMRQGVIAQRtawIREQAKFYLESGVPI 86
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEA---EALAAAAAAEAGGVK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489  87 DVKVVWHNRPFEAIIQEVISEKHDLLLKMAHQHDKLEAVIFTPTDWHLLRKCPCPVWMVK 146
Cdd:pfam00582  78 VEVVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
157-298 1.11e-17

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 78.04  E-value: 1.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489 157 LVAVNLaSEENyhntlnEKLVRETLSLAEEVNhTEVHLIGAYPVTPiniaieLPDFDPSVYNDAIRGQHLLAMKALRQKF 236
Cdd:COG0589     6 LVPTDG-SEEA------ERALEYAAELAKALG-AELHLLHVVDPPP------SAAAGPEELEEELREEAEEALEEAAERL 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2090923489 237 ---GIDEKfTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGLSAAFLGNTAEQVVDHLRCDLLV 298
Cdd:COG0589    72 eeaGVEVE-TVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
 
Name Accession Description Interval E-value
PRK11175 PRK11175
universal stress protein UspE; Provisional
 2-306 0e+00

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 642.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489   2 AKYQSMLVVIDPNQDDQPALRRAVYLHQRIGGRIKAFLPIYDFSYEMTTLLSPDERTAMRQGVIAQRTAWIREQAKFYLE 81
Cdd:PRK11175    1 AKYQNILVVIDPNQDDQPALRRAVYLAQRNGGKITAFLPIYDFSYEMTTLLSPDEREAMRQGVISQRTAWIREQAKPYLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489  82 SGVPIDVKVVWHNRPFEAIIQEVISEKHDLLLKMAHQHDKLEAVIFTPTDWHLLRKCPCPVWMVKDQPWPEGGKALVAVN 161
Cdd:PRK11175   81 AGIPIEIKVVWHNRPFEAIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQDWPEGGKILVAVN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489 162 LASEENYHNTLNEKLVRETLSLAEEVNHTEVHLIGAYPVTPINIAIELPDFDPSVYNDAIRGQHLLAMKALRQKFGIDEK 241
Cdd:PRK11175  161 VASEEPYHDALNEKLVEEAIDLAEQLNHAEVHLVNAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGIDEE 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2090923489 242 FTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGLSAAFLGNTAEQVVDHLRCDLLVLKPEAYQT 306
Cdd:PRK11175  241 QTHVEEGLPEEVIPDLAEHLDAELVILGTVGRTGLSAAFLGNTAEHVIDHLNCDLLAIKPDGYVS 305
USP-E_repeat1 cd23943
Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP ...
 4-146 3.44e-97

Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467508  Cd Length: 143  Bit Score: 282.90  E-value: 3.44e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489   4 YQSMLVVIDPNQDDQPALRRAVYLHQRIGGRIKAFLPIYDFSYEMTTLLSPDERTAMRQGVIAQRTAWIREQAKFYLESG 83
Cdd:cd23943     1 YQNMLVVIDPNQDDQPALRRAVYLVQRIGGKIKAFLPIYDLSYEMTTLLSPDERTAMRQGVISQRTAWIREQAKYYLEAG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2090923489  84 VPIDVKVVWHNRPFEAIIQEVISEKHDLLLKMAHQHDKLEAVIFTPTDWHLLRKCPCPVWMVK 146
Cdd:cd23943    81 IPIEIKVVWHNRPFEAIIQEVIAGNHDLVLKMAHQHDRLESLIFTPTDWHLLRKCPSPVWMVK 143
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 153-301 4.57e-76

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 229.46  E-value: 4.57e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489 153 GGKALVAVNLASEENYHNTLNEKLVRETLSLAEEVNhTEVHLIGAYPVTPINIAIELPDFDPSVYNDAIRGQHLLAMKAL 232
Cdd:cd23660     1 GGRILVAVDPSNEEEYHEDLNLRLIELAYSLAAQLK-AELHLVSAWPVTPENIAIELPEFDPTEYVDAIRGRHLEAMKAL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2090923489 233 RQKFGIDEKFTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGLSAAFLGNTAEQVVDHLRCDLLVLKP 301
Cdd:cd23660    80 RQKFGIDEEQTHVLEGLPEEVIPDFAEELDADIVVLGTVARTGLSGALIGNTAEHVLDHLNCDLLALKP 148
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 7-146 1.82e-19

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 82.84  E-value: 1.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489   7 MLVVIDPNQDDQPALRRAVYLHQRIGGRIKAFLPIYDFSYEMTTLLSPDERTAMRQGVIAQRtawIREQAKFYLESGVPI 86
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEA---EALAAAAAAEAGGVK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489  87 DVKVVWHNRPFEAIIQEVISEKHDLLLKMAHQHDKLEAVIFTPTDWHLLRKCPCPVWMVK 146
Cdd:pfam00582  78 VEVVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
157-298 1.11e-17

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 78.04  E-value: 1.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489 157 LVAVNLaSEENyhntlnEKLVRETLSLAEEVNhTEVHLIGAYPVTPiniaieLPDFDPSVYNDAIRGQHLLAMKALRQKF 236
Cdd:COG0589     6 LVPTDG-SEEA------ERALEYAAELAKALG-AELHLLHVVDPPP------SAAAGPEELEEELREEAEEALEEAAERL 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2090923489 237 ---GIDEKfTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGLSAAFLGNTAEQVVDHLRCDLLV 298
Cdd:COG0589    72 eeaGVEVE-TVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 7-145 2.65e-16

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 74.31  E-value: 2.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489   7 MLVVIDPNQDDQPALRRAVYLHQRIGGRIKAFLPIYDFSYEMTtllsPDERTAMRQGVIAQRTAWIREQAKFYLESGVPI 86
Cdd:cd00293     2 ILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSL----SGGLEELADELKEEAEELLEEAKKLAEEAGVEV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2090923489  87 DVKVVWHNrPFEAIIQEVISEKHDLLLKMAHQHDKLEAVIFTPTDWHLLRKCPCPVWMV 145
Cdd:cd00293    78 ETIVVEGD-PAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-145 1.34e-15

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 72.26  E-value: 1.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489   3 KYQSMLVVIDPNQDDQPALRRAVYLHQRIGGRIKAFLpIYDFSYEMttllsPDERTAMRQGVIAQRTAWIREQAKFYLES 82
Cdd:COG0589     1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLH-VVDPPPSA-----AAGPEELEEELREEAEEALEEAAERLEEA 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2090923489  83 GVPIDVKVVwHNRPFEAIIQEVISEKHDLLLKMAHQHDKLEAVIFTPTDWHLLRKCPCPVWMV 145
Cdd:COG0589    75 GVEVETVVR-EGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLVV 136
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 157-298 1.57e-13

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 66.60  E-value: 1.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489 157 LVAVNLaSEENyhntlnEKLVRETLSLAEeVNHTEVHLIGAYPVTPINIAIELPDFDPSVYNDAIRgQHLLAMKALRQKF 236
Cdd:cd00293     3 LVAVDG-SEES------ERALEWALELAK-RPGAELTLLHVVDPPPSSSLSGGLEELADELKEEAE-ELLEEAKKLAEEA 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2090923489 237 GIDEKfTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGLSAAFLGNTAEQVVDHLRCDLLV 298
Cdd:cd00293    74 GVEVE-TIVVEGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 174-300 7.71e-13

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 64.74  E-value: 7.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489 174 EKLVRETLSLAEEvNHTEVHLIGAYPVTPINIAIEL-PDFDPSVYNDAIRGQHLLAMKALRQKFGIDEKfTHVEKGLPEE 252
Cdd:pfam00582  12 KRALEWAAELAKA-RGAELILLHVIDPPPSGAASLAdESAEEEELELELAEAEALAAAAAAEAGGVKVE-VVVVVGDPAE 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2090923489 253 VIPDLAEHLQAGIVVLGTVGRTGLSAAFLGNTAEQVVDHLRCDLLVLK 300
Cdd:pfam00582  90 EILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 222-300 1.87e-07

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 49.54  E-value: 1.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090923489 222 RGQHLL--AMKALRQKFGIDEKFtHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGLSAAFLGNTAEQVVDHLRCDLLVL 299
Cdd:cd23659    64 KAEKLLekYEKKLKEEKGIKVKV-EVVAGDPGEVICKAAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVLVV 142


                  .
gi 2090923489 300 K 300
Cdd:cd23659   143 R 143
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 228-301 6.69e-05

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 42.29  E-value: 6.69e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2090923489 228 AMKALRQKFGIDEKFTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGLSaaFLGNTAEQVVDHLRCDLLVLKP 301
Cdd:cd23657    67 ALKNLSELAGYPVDHTFIGYGDLKEEILEVAKKHNVDLIVCGHHGDFGLS--LLGSSARAVLNSAPCDVLIVPL 138
USP_Rv2623_repeat2 cd23661
universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis ...
 245-300 7.55e-03

universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition, Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467507 [Multi-domain]  Cd Length: 133  Bit Score: 35.95  E-value: 7.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2090923489 245 VEKGLPEEVIPDLAEhlQAGIVVLGTVGRTGLSAAFLGNTAEQVVDHLRCDLLVLK 300
Cdd:cd23661    80 VVRDRPARVLLEASE--RAQLVVVGSHGRGGFAGMLLGSVSRAVLHSAPCPVIVVR 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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