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Conserved domains on  [gi|2095221065|gb|UAS07168|]
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trehalose operon repressor [Staphylococcus pseudintermedius]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
trehalos_R_Bsub super family cl37105
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 6-239 1.72e-65

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


The actual alignment was detected with superfamily member TIGR02404:

Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 202.98  E-value: 1.72e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   6 KFQYIYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVVIYQGVTEFPFADLKSF 85
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEFPISGITSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065  86 KEVQTQLGLHYETVVVRFEKIKAADvPQVKKALEMTTDEELWHFIRYRQIEGITKIVDEDYVRANLFPELSEAVVQNSLY 165
Cdd:TIGR02404  81 KELNETLGLDSKTEVVELDKEDPLP-ETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIY 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095221065 166 DYIEKVKGYEISFSSKSITFEPFGELERAAFGDVTPQYSATVRGIVHLKDTTKFQYNVSKHIATEFKFIDFSRR 239
Cdd:TIGR02404 160 QYLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKFVDFARR 233
 
Name Accession Description Interval E-value
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 6-239 1.72e-65

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 202.98  E-value: 1.72e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   6 KFQYIYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVVIYQGVTEFPFADLKSF 85
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEFPISGITSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065  86 KEVQTQLGLHYETVVVRFEKIKAADvPQVKKALEMTTDEELWHFIRYRQIEGITKIVDEDYVRANLFPELSEAVVQNSLY 165
Cdd:TIGR02404  81 KELNETLGLDSKTEVVELDKEDPLP-ETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIY 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095221065 166 DYIEKVKGYEISFSSKSITFEPFGELERAAFGDVTPQYSATVRGIVHLKDTTKFQYNVSKHIATEFKFIDFSRR 239
Cdd:TIGR02404 160 QYLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKFVDFARR 233
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-239 2.34e-47

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 156.56  E-value: 2.34e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   6 KFQYIYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVVIYQGVTEfPFADLKSF 85
Cdd:COG2188     6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY-PLSRLTSF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065  86 KEVQTQLGLHYETVVVRFEKIKAAdvPQVKKALEMTTDEELWHFIRYRQIEGITKIVDEDYVRANLFPELSEA-VVQNSL 164
Cdd:COG2188    85 TEELRARGREPSTRVLSAERVPAD--EEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEdLETGSL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2095221065 165 YDYIEKVKGYEISFSSKSITFEPFGELERAAFGdvTPQYSA--TVRGIVHLKDTTKFQYNVSKHIATEFKF-IDFSRR 239
Cdd:COG2188   163 YELLEERYGLRITRAEQRIEAVLADAEEAELLG--VPPGAPvlVIERVTYDADGRPVEYSRSYYRGDRYRFvVELRRR 238
PRK09764 PRK09764
GntR family transcriptional regulator;
1-242 9.60e-26

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 100.67  E-value: 9.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   1 MKNQNKFQYIYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVVIYQGVtEFPFA 80
Cdd:PRK09764    1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERV-NYDIF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065  81 DLKSFKEVQTQLGLHYETVVVRFEKIKAADVpqVKKALEMTTDEELWHFIRYRQIEGITKIVDEDYVRANLFPELSEAVV 160
Cdd:PRK09764   80 QLTSFDEKLSDRHVDTHSEVLIFEVIPADDF--LQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVM 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065 161 QNSLYDYIEKVKGYEISFSSKSIT-FEPFGELERAAFGDVT-PQYSATVRGivHLKDTTKFQYNVSKHIATEFKFIDFSR 238
Cdd:PRK09764  158 ENSKYHFIEEVKKMVIDRSEQEIIpLMPTEEMSRLLNISQTkPILEKVSRG--YLVDGRVFEYSRNAFNTDDYKFTLIAQ 235


                  ....
gi 2095221065 239 RHSH 242
Cdd:PRK09764  236 RKSS 239
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 6-69 8.22e-19

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 77.49  E-value: 8.22e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095221065   6 KFQYIYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVV 69
Cdd:cd07377     2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 91-232 1.73e-17

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 76.18  E-value: 1.73e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   91 QLGLHYETVVVRFEKIKAAdvPQVKKALEMTTDEELWHFIRYRQIEGITKIVDEDYVRANLFPELSEAVVQNSLYDYIEK 170
Cdd:smart00866   1 AQGRKPTTKVLSFERVPAD--EELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEE 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2095221065  171 VKGYEISFSS---KSITFEPFGELERAAFGDVTPQYSATVRGIVHLKDTTKFQYNVSKHIATEFK 232
Cdd:smart00866  79 RLGLKIVRSTraeQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 10-69 2.54e-16

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 70.72  E-value: 2.54e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065  10 IYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVV 69
Cdd:pfam00392   5 VYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
 
Name Accession Description Interval E-value
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 6-239 1.72e-65

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 202.98  E-value: 1.72e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   6 KFQYIYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVVIYQGVTEFPFADLKSF 85
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEFPISGITSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065  86 KEVQTQLGLHYETVVVRFEKIKAADvPQVKKALEMTTDEELWHFIRYRQIEGITKIVDEDYVRANLFPELSEAVVQNSLY 165
Cdd:TIGR02404  81 KELNETLGLDSKTEVVELDKEDPLP-ETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIY 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095221065 166 DYIEKVKGYEISFSSKSITFEPFGELERAAFGDVTPQYSATVRGIVHLKDTTKFQYNVSKHIATEFKFIDFSRR 239
Cdd:TIGR02404 160 QYLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKFVDFARR 233
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-239 2.34e-47

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 156.56  E-value: 2.34e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   6 KFQYIYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVVIYQGVTEfPFADLKSF 85
Cdd:COG2188     6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY-PLSRLTSF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065  86 KEVQTQLGLHYETVVVRFEKIKAAdvPQVKKALEMTTDEELWHFIRYRQIEGITKIVDEDYVRANLFPELSEA-VVQNSL 164
Cdd:COG2188    85 TEELRARGREPSTRVLSAERVPAD--EEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEdLETGSL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2095221065 165 YDYIEKVKGYEISFSSKSITFEPFGELERAAFGdvTPQYSA--TVRGIVHLKDTTKFQYNVSKHIATEFKF-IDFSRR 239
Cdd:COG2188   163 YELLEERYGLRITRAEQRIEAVLADAEEAELLG--VPPGAPvlVIERVTYDADGRPVEYSRSYYRGDRYRFvVELRRR 238
PRK09764 PRK09764
GntR family transcriptional regulator;
1-242 9.60e-26

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 100.67  E-value: 9.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   1 MKNQNKFQYIYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVVIYQGVtEFPFA 80
Cdd:PRK09764    1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERV-NYDIF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065  81 DLKSFKEVQTQLGLHYETVVVRFEKIKAADVpqVKKALEMTTDEELWHFIRYRQIEGITKIVDEDYVRANLFPELSEAVV 160
Cdd:PRK09764   80 QLTSFDEKLSDRHVDTHSEVLIFEVIPADDF--LQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVM 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065 161 QNSLYDYIEKVKGYEISFSSKSIT-FEPFGELERAAFGDVT-PQYSATVRGivHLKDTTKFQYNVSKHIATEFKFIDFSR 238
Cdd:PRK09764  158 ENSKYHFIEEVKKMVIDRSEQEIIpLMPTEEMSRLLNISQTkPILEKVSRG--YLVDGRVFEYSRNAFNTDDYKFTLIAQ 235


                  ....
gi 2095221065 239 RHSH 242
Cdd:PRK09764  236 RKSS 239
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 6-69 8.22e-19

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 77.49  E-value: 8.22e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095221065   6 KFQYIYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVV 69
Cdd:cd07377     2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 91-232 1.73e-17

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 76.18  E-value: 1.73e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   91 QLGLHYETVVVRFEKIKAAdvPQVKKALEMTTDEELWHFIRYRQIEGITKIVDEDYVRANLFPELSEAVVQNSLYDYIEK 170
Cdd:smart00866   1 AQGRKPTTKVLSFERVPAD--EELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEE 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2095221065  171 VKGYEISFSS---KSITFEPFGELERAAFGDVTPQYSATVRGIVHLKDTTKFQYNVSKHIATEFK 232
Cdd:smart00866  79 RLGLKIVRSTraeQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 10-69 2.54e-16

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 70.72  E-value: 2.54e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065  10 IYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVV 69
Cdd:pfam00392   5 VYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 91-232 3.15e-16

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 73.01  E-value: 3.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065  91 QLGLHYETVVVRFEKIKAadVPQVKKALEMTTDEELWHFIRYRQIEGITKIVDEDYVRANLFPELSEAVV-QNSLYDYIE 169
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPA--SAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLeEGSLYDYLE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2095221065 170 KVKGYEISFSSKSITFEPFGELERAAFGDVTPQYSATVRGIVHLKDTTKFQYNVSKHIATEFK 232
Cdd:pfam07702  79 ERYGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
10-69 1.42e-13

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 63.36  E-value: 1.42e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   10 IYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVV 69
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
1-69 3.57e-13

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 66.50  E-value: 3.57e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2095221065   1 MKNQNKFQYIYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVV 69
Cdd:COG2186     3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFV 71
PRK11402 PRK11402
transcriptional regulator PhoB;
1-170 3.04e-12

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 64.09  E-value: 3.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   1 MKNQNKFQYIYERLRIAILE----GEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVVIYQGVTE 76
Cdd:PRK11402    1 ATDRYSHQLLYATVRQRLLDdiaqGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVEN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065  77 FPFAdLKSFKEVQTQLGLHYETVVVRFEKIKAADVPQvkkALEMTTDEELWHFIRYRQIEGITKIVDEDYVRANLFPELS 156
Cdd:PRK11402   81 ALLT-VSGFTDFGVSQGKATKEKVIEQERVSAAPFCE---KLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFD 156

                         170
                  ....*....|....*
gi 2095221065 157 EAVVQN-SLYDYIEK 170
Cdd:PRK11402  157 EIYVEGsSTYQLFQE 171
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
8-119 3.37e-11

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 61.09  E-value: 3.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   8 QYIYERLRIAILEGEYEYGEQLlSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVviyqgVTEFPFADLKSFKE 87
Cdd:COG1802    14 EQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGAR-----VAPLSPEEIRELYE 87

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2095221065  88 VQTQLglhyETVVVR--FEKIKAADVPQVKKALE 119
Cdd:COG1802    88 VRAAL----EGLAARlaAERATPADLARLRALLE 117
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 6-184 1.32e-08

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 53.63  E-value: 1.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   6 KFQYIYERLRIAiLEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVVIYQGVtEFPFADLKSF 85
Cdd:PRK10079   13 RYQEIAAKLEQE-LRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPY-DYPLNAQARF 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065  86 KEVQTQLGLHYETvvvrfEKIKAADVP---QVKKALEMTTDEELWHFIRYRQIEGITKIVDEDYvranlFPELS-EAVVQ 161
Cdd:PRK10079   91 SQNLLDQGSHPTS-----EKLLSVLRPasgHVADALGITEGENVIHLRTLRRVNGVALCLIDHY-----FADLTwWPTLQ 160

                         170       180
                  ....*....|....*....|....*..
gi 2095221065 162 N----SLYDYIEKVKGYEISFSSKSIT 184
Cdd:PRK10079  161 RfdsgSLHDFLREQLGIALRRSQTRIS 187
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 6-69 6.95e-08

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 52.52  E-value: 6.95e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095221065   6 KFQYIYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVV 69
Cdd:COG1167    13 LYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFV 76
PRK10225 PRK10225
Uxu operon transcriptional regulator;
4-124 3.12e-07

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 50.02  E-value: 3.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065   4 QNKFQYIYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVVI-------YQGVTE 76
Cdd:PRK10225    8 QRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLdssgshnTDSPDA 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2095221065  77 FPFADLKSFKEVQTQLGLhyETVVVRFEKIKAA--DVPQVKKALEMTTDE 124
Cdd:PRK10225   88 NVCNDAGPFELLQARQLL--ESNIAEFAALQATreDIVKMRQALQLEERE 135
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
10-94 1.18e-05

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 45.01  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095221065  10 IYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVV---IYQGVTEfPFADLKSfK 86
Cdd:PRK09464   15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVqssLWQSFSD-PLVELLS-D 92


                  ....*...
gi 2095221065  87 EVQTQLGL 94
Cdd:PRK09464   93 HPESQFDL 100
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 12-69 9.43e-05

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 42.45  E-value: 9.43e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2095221065  12 ERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVV 69
Cdd:PRK09990   14 ERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFV 71
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 10-72 1.68e-04

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 41.68  E-value: 1.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2095221065  10 IYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVVIYQ 72
Cdd:PRK10421    7 VADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWR 69
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 12-81 3.84e-04

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 40.50  E-value: 3.84e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2095221065  12 ERLRiAILEgeyeygeqLLSEH------QLVKKYNVSRETVRKSLNMLVLDGMIQKIRGkGSVVIYQGVTEFPFAD 81
Cdd:COG1349     5 ERRQ-KILE--------LLRERgrvsveELAERLGVSEETIRRDLAELEEQGLLRRVHG-GAVLVSSAAAEPPFAE 70
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 10-60 1.33e-03

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 38.85  E-value: 1.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2095221065  10 IYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQ 60
Cdd:PRK03837   18 VEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQ 68
PRK11523 PRK11523
transcriptional regulator ExuR;
7-70 2.69e-03

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 38.29  E-value: 2.69e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095221065   7 FQYIYERLRIAILEGEYEYGEQLLSEHQLVKKYNVSRETVRKSLNMLVLDGMIQKIRGKGSVVI 70
Cdd:PRK11523   10 YQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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