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Conserved domains on  [gi|2095302239|gb|UAS75986|]
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metal-dependent transcriptional regulator [Staphylococcus pseudintermedius]

Protein Classification

metal-dependent transcriptional regulator( domain architecture ID 11442488)

metal-dependent transcriptional regulator may be activated by one or more from a variety of metal ions such as Mn, Cd, Co, Ni, and Fe, among others, and may function as an activator or repressor of gene expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-132 1.99e-52

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


:

Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 164.99  E-value: 1.99e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095302239   1 MLTEEKEDYLKAILSHDGIDTYVSNKTLSRFLNIKPPSVSEMVGRLEKEGYVMTKPYKGVKLSELGLSYTLDVIKRHRLI 80
Cdd:COG1321     3 MLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRLL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2095302239  81 ELFLIEVLNYTWEEVHVEAEVLEHRVSKLFVERLDELLKYPKTCPHGGVIPR 132
Cdd:COG1321    83 ERFLVEVLGVDWDEAHEEAERLEHVLSDETIERLDAFLGFPEEDPHGDPIPD 134
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 142-214 3.30e-06

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


:

Pssm-ID: 461133  Cd Length: 74  Bit Score: 43.35  E-value: 3.30e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095302239 142 IPLLSFEEGDVVTIRRVRDRS-ELLVFLSSKALSIGDTVKVIAKDDINRLMELENKGEKIVLSYQNAEVIFGEK 214
Cdd:pfam04023   1 MPLSELKEGETARIVRIRDGDpELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVEP 74
 
Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-132 1.99e-52

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 164.99  E-value: 1.99e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095302239   1 MLTEEKEDYLKAILSHDGIDTYVSNKTLSRFLNIKPPSVSEMVGRLEKEGYVMTKPYKGVKLSELGLSYTLDVIKRHRLI 80
Cdd:COG1321     3 MLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRLL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2095302239  81 ELFLIEVLNYTWEEVHVEAEVLEHRVSKLFVERLDELLKYPKTCPHGGVIPR 132
Cdd:COG1321    83 ERFLVEVLGVDWDEAHEEAERLEHVLSDETIERLDAFLGFPEEDPHGDPIPD 134
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 25-118 1.07e-29

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 105.76  E-value: 1.07e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095302239   25 NKTLSRFLNIKPPSVSEMVGRLEKEGYVMTKPYKGVKLSELGLSYTLDVIKRHRLIELFLIEVLNYTWEEVHVEAEVLEH 104
Cdd:smart00529   1 TSEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVDVLGVDEEEVHEEAERLEH 80

                           90
                   ....*....|....
gi 2095302239  105 RVSKLFVERLDELL 118
Cdd:smart00529  81 VLSDELEDRLDRFL 94
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 64-131 6.01e-26

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 95.23  E-value: 6.01e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2095302239  64 ELGLSYTLDVIKRHRLIELFLIEVLNYTWEEVHVEAEVLEHRVSKLFVERLDELLKYPKTCPHGGVIP 131
Cdd:pfam02742   2 EKGRKIALRVVRRHRLLERFLVDVLGVDWDEVHEEAERLEHALSDELIDRLDEFLGFPETCPHGDPIP 69
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
7-107 2.11e-10

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 56.94  E-value: 2.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095302239   7 EDYLKAI---LSHDGIDTYVSnktLSRFLNIKPPSVSEMVGRLEKEGYVMTKPYKGVKLSELGLSYTLDVIKRHRLIELF 83
Cdd:PRK11050   36 EDYVELIadlIAEVGEARQVD---IAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVFLTPEGEKLAQESRERHQIVENF 112

                          90       100
                  ....*....|....*....|....
gi 2095302239  84 LIeVLNYTWEEVHVEAEVLEHRVS 107
Cdd:PRK11050  113 LL-ALGVSPETARRDAEGIEHHVS 135
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 142-214 3.30e-06

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 43.35  E-value: 3.30e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095302239 142 IPLLSFEEGDVVTIRRVRDRS-ELLVFLSSKALSIGDTVKVIAKDDINRLMELENKGEKIVLSYQNAEVIFGEK 214
Cdd:pfam04023   1 MPLSELKEGETARIVRIRDGDpELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVEP 74
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
142-214 2.85e-03

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 35.49  E-value: 2.85e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2095302239 142 IPLLSFEEGDVVTIRRVRDRSELLVFLSSKALSIGDTVKVIAKDDINRLMELENKGEKIVLSYQNAEVIFGEK 214
Cdd:COG1918     1 MTLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVEP 73
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 142-214 4.71e-03

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 34.85  E-value: 4.71e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095302239  142 IPLLSFEEGDVVTIRRVRDRS-ELLVFLSSKALSIGDTVKVIAKDDINRLmeLENKGEKIVLSYQNAEVIFGEK 214
Cdd:smart00899   1 MPLSELKPGEKARIVRIRDEDpELLRRLLELGLVPGTEVTVLRKAPFGPL--VVRVGGELALRREEAEKIFVEP 72
 
Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-132 1.99e-52

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 164.99  E-value: 1.99e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095302239   1 MLTEEKEDYLKAILSHDGIDTYVSNKTLSRFLNIKPPSVSEMVGRLEKEGYVMTKPYKGVKLSELGLSYTLDVIKRHRLI 80
Cdd:COG1321     3 MLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRLL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2095302239  81 ELFLIEVLNYTWEEVHVEAEVLEHRVSKLFVERLDELLKYPKTCPHGGVIPR 132
Cdd:COG1321    83 ERFLVEVLGVDWDEAHEEAERLEHVLSDETIERLDAFLGFPEEDPHGDPIPD 134
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 25-118 1.07e-29

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 105.76  E-value: 1.07e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095302239   25 NKTLSRFLNIKPPSVSEMVGRLEKEGYVMTKPYKGVKLSELGLSYTLDVIKRHRLIELFLIEVLNYTWEEVHVEAEVLEH 104
Cdd:smart00529   1 TSEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVDVLGVDEEEVHEEAERLEH 80

                           90
                   ....*....|....
gi 2095302239  105 RVSKLFVERLDELL 118
Cdd:smart00529  81 VLSDELEDRLDRFL 94
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 64-131 6.01e-26

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 95.23  E-value: 6.01e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2095302239  64 ELGLSYTLDVIKRHRLIELFLIEVLNYTWEEVHVEAEVLEHRVSKLFVERLDELLKYPKTCPHGGVIP 131
Cdd:pfam02742   2 EKGRKIALRVVRRHRLLERFLVDVLGVDWDEVHEEAERLEHALSDELIDRLDEFLGFPETCPHGDPIP 69
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 4-60 1.04e-16

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 71.25  E-value: 1.04e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2095302239   4 EEKEDYLKAILSHDGIDTYVSNKTLSRFLNIKPPSVSEMVGRLEKEGYVMTKPYKGV 60
Cdd:pfam01325   1 ESTEDYLETIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYVDYEPYKGL 57
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
7-107 2.11e-10

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 56.94  E-value: 2.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095302239   7 EDYLKAI---LSHDGIDTYVSnktLSRFLNIKPPSVSEMVGRLEKEGYVMTKPYKGVKLSELGLSYTLDVIKRHRLIELF 83
Cdd:PRK11050   36 EDYVELIadlIAEVGEARQVD---IAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVFLTPEGEKLAQESRERHQIVENF 112

                          90       100
                  ....*....|....*....|....
gi 2095302239  84 LIeVLNYTWEEVHVEAEVLEHRVS 107
Cdd:PRK11050  113 LL-ALGVSPETARRDAEGIEHHVS 135
PRK03902 PRK03902
transcriptional regulator MntR;
1-120 8.09e-09

transcriptional regulator MntR;


Pssm-ID: 179669 [Multi-domain]  Cd Length: 142  Bit Score: 52.31  E-value: 8.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095302239   1 MLTEEKEDYLKAILSHDGIDTYVSNKTLSRFLNIKPPSVSEMVGRLEKEGYVMTKPYKGVKLSELGLSYTLDVIKRHRLI 80
Cdd:PRK03902    1 MPTPSMEDYIEQIYLLIEEKGYARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTPKGKKIGKRLVYRHELL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2095302239  81 ELFLiEVLNYTWEEVHVEAEVLEHRVSKLFVERLDELLKY 120
Cdd:PRK03902   81 EQFL-RIIGVDESKIYNDVEGIEHHLSWNAIDRIGDLVQY 119
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 142-214 3.30e-06

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 43.35  E-value: 3.30e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095302239 142 IPLLSFEEGDVVTIRRVRDRS-ELLVFLSSKALSIGDTVKVIAKDDINRLMELENKGEKIVLSYQNAEVIFGEK 214
Cdd:pfam04023   1 MPLSELKEGETARIVRIRDGDpELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVEP 74
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
142-214 2.85e-03

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 35.49  E-value: 2.85e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2095302239 142 IPLLSFEEGDVVTIRRVRDRSELLVFLSSKALSIGDTVKVIAKDDINRLMELENKGEKIVLSYQNAEVIFGEK 214
Cdd:COG1918     1 MTLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVEP 73
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
10-52 3.17e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 34.33  E-value: 3.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2095302239  10 LKAILSHDGIdtyvSNKTLSRFLNIKPPSVSEMVGRLEKEGYV 52
Cdd:pfam13412   7 LNLLQENPRI----SQRELAERLGLSPSTVNRRLKRLEEEGVI 45
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 142-214 4.71e-03

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 34.85  E-value: 4.71e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095302239  142 IPLLSFEEGDVVTIRRVRDRS-ELLVFLSSKALSIGDTVKVIAKDDINRLmeLENKGEKIVLSYQNAEVIFGEK 214
Cdd:smart00899   1 MPLSELKPGEKARIVRIRDEDpELLRRLLELGLVPGTEVTVLRKAPFGPL--VVRVGGELALRREEAEKIFVEP 72
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
10-52 7.03e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 35.72  E-value: 7.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2095302239  10 LKAILSHDGIdtyvSNKTLSRFLNIKPPSVSEMVGRLEKEGYV 52
Cdd:COG1846    44 LAALAEAGGL----TQSELAERLGLTKSTVSRLLDRLEEKGLV 82
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
2-52 8.00e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 34.88  E-value: 8.00e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2095302239    2 LTEEKEDYLKAILSHDGIdtyvSNKTLSRFLNIKPPSVSEMVGRLEKEGYV 52
Cdd:smart00347   8 LTPTQFLVLRILYEEGPL----SVSELAKRLGVSPSTVTRVLDRLEKKGLV 54
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 8-56 9.86e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 33.33  E-value: 9.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2095302239   8 DYLKAILSHDGidtyVSNKTLSRFLNIKPPSVSEMVGRLEKEGYVMTKP 56
Cdd:pfam12802   9 RVLLALARNPG----LTVAELARRLGISKQTVSRLVKRLEAKGLVEREP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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