|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
17-412 |
5.92e-125 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 367.82 E-value: 5.92e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 17 LGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAG 96
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 97 SWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFA 176
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 177 WAIAWLIFYKHPRDQKKLSDEERDYIIGGQ----ESQHQTNNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPL 252
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWLTEEEKYIVVGGllaeQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 253 FMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWfGVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYVAIALL 332
Cdd:TIGR00893 241 YLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRR-GKSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALALV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 333 CIGGFAHQAlSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIG-FSPLFAVLAVFDLLGALVIWTV 411
Cdd:TIGR00893 320 ALGFFGLGA-GAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGsFAGALMVVAALALIGALSYLLL 398
|
.
gi 2095916352 412 L 412
Cdd:TIGR00893 399 V 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
8-411 |
1.18e-92 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 283.69 E-value: 1.18e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAI 87
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 88 FCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 168 IISGVLSFAWAIAWLIFYkhprdqkklsdeerdyiiggqesqhqtnnakkmspwqilrnRQFWGIALPRFLAEPAWGTFN 247
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL-----------------------------------------RQVWGLALGYFGINYALYGLL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 248 AWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWfgvnliVSRKMVVTMGALLMIGPGMIGLFTSPYV 327
Cdd:cd17319 200 TWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG------ARRLVIIIGLLLAAVGLLLAYLTTSPVV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 328 AIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALAD-TIGFSPLFAVLAVFDLLGAL 406
Cdd:cd17319 274 AVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSYTAAFLFLAAVALLAAL 353
|
....*
gi 2095916352 407 VIWTV 411
Cdd:cd17319 354 LVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-413 |
9.09e-68 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 219.74 E-value: 9.09e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 1 MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAF 80
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 81 FAIAWAIFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM 160
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 161 HSWQMAFIISGVLSFAWAIAwlifykhprdqkklsdeerdyiiggqesqhqtnnakkmspwqilrnrQFWGIALPRFLAE 240
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL-----------------------------------------------RFWLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 241 PAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvnliVSRKMVVTMGALLMIGPGMIG 320
Cdd:COG2271 194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR-------RRKLVLAIGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 321 LFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVF 400
Cdd:COG2271 267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
|
410
....*....|...
gi 2095916352 401 DLLGALVIWTVLK 413
Cdd:COG2271 347 ALLAALLALLLLR 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-417 |
1.40e-46 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 165.05 E-value: 1.40e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAI 87
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 88 FCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 168 IISGVLSFAWAIAWLIFYKHPrdqkklsdeerdyiiggQESQHQTNNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTFN 247
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDP-----------------PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 248 AWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvnlivsRKMVVTMGALLMIGPGMIGLFT-SPY 326
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG---------RRVLLIVFALMALGLLLLALALgSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 327 VAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIG-FSPLFAVLAVFDLLGA 405
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVAL 376
|
410
....*....|..
gi 2095916352 406 LVIWTVLKNKPA 417
Cdd:COG2223 377 VLTLLLYRRPRR 388
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-375 |
4.90e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 132.79 E-value: 4.90e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 1 MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAF 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 81 FAIAWAIFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 161 HSWQMAFIISGVLSFAWAIAWLIFYKhprdqkklsdeerdyiiggqESQHQTNNAKKMSPWQILRNRQFWGIALPRFLAE 240
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLP--------------------ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 241 PAWGTFNAWIPLFMFKVYGFNLKEIAMFawmpMLFADLGCIVGGYLPPLFQRWFGvnlivSRKMVVTMGALLMIGPGMIG 320
Cdd:COG2814 221 FGFFALFTYLPLYLQEVLGLSASAAGLL----LALFGLGGVLGALLAGRLADRFG-----RRRLLLIGLLLLALGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 2095916352 321 LFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLAST 375
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-378 |
6.22e-34 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 129.85 E-value: 6.22e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 15 VTLGTVLGYLTRNTVAAAAP-TLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTA 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 94 LAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVL 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 174 SFAWAIAWLIFYKHPRDQKKLSDEERDYIIggqesqhqtnnakkMSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLF 253
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSL--------------IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 254 MfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWfgvnlivsRKMVVTMGALLMIGPGM--IGLFTSPYVAIAL 331
Cdd:pfam07690 227 Q-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR--------RRLLLALLLLILAALGLllLSLTLSSLWLLLA 297
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2095916352 332 LCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFA 378
Cdd:pfam07690 298 LLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
34-409 |
1.36e-32 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 126.54 E-value: 1.36e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK----VGYAFFAIAWAIFcgstALAGSWGGLALARGAVG 109
Cdd:cd17325 20 PLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKrlllLGLLLLAVSTLLF----AFATSYWQLLLARFLQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 110 AAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAwAIAWLIFYKHPR 189
Cdd:cd17325 96 LASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL-ALVLALLLLPEP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 190 DQKKLSDEERDYIIGGqesqhqtnnakkmSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFA 269
Cdd:cd17325 175 RPPPNKRAVSAARLRS-------------GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 270 WMPMLFADLGCIVGGYLPplfqRWFGvnlivsRKMVVTMGALLM-IGPGMIGLFTSPYVAIALLCIGGFAHQALSGALIT 348
Cdd:cd17325 242 GAQGLASALSQPPAGKLS----DRIG------RKPLILIGLLLSaVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095916352 349 LSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17325 312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
16-394 |
5.96e-31 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 122.10 E-value: 5.96e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 16 TLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALA 95
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 96 GSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMH-SWQMAFIISGVLS 174
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 175 FAWAIAWLIFYKHPRDQKKLSDEERDYIiggQESQHQTNNAKK-MSPWQI-----LRNRQFWGIALPR-FLAEPAWGtFN 247
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPN---EEPDGDAEKKEEeLTKKQIflqyvLLNKVLWYISLGYvFVYVVRTG-IL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 248 AWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLF--QRWFGVNLIVSRKMVVTMGALLMIgpgmigLFTSP 325
Cdd:TIGR00881 237 DWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLN------PAANP 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095916352 326 YVAIALLCIGGF---AHQALSGaliTLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPLF 394
Cdd:TIGR00881 311 LMDLICLFALGFlvyGPQMLIG---VIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-409 |
4.87e-29 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 116.76 E-value: 4.87e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 15 VTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTAL 94
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 95 AGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAI--VMHSWQMAFIISGV 172
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 173 LSFAWAIAWLIFYKHPRDQKKLSDEERDYIIGGQesqhqtnnakkmSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPL 252
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLK------------LLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 253 FMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGylpplfqrWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYVAIALL 332
Cdd:cd06174 229 FLLDLGGLSVAVAGLLLSLFGLAGALGSLLLG--------LLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2095916352 333 CIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALAD-TIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd06174 301 LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
5-418 |
1.09e-25 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 107.63 E-value: 1.09e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 5 KGLRWYMIALVTLGTVLGYLTrNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIA 84
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFAT-ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 85 WAIFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIaVGYFNVGSSIGAMIAPPLVVWAIVMH--- 161
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGlsl 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 162 SWQMAFIISGVLSFAWAIaWLIFYKHPRDQKKLSDEErdyiiggqesqhqtnnAKKMSPWQILRNRQFWGIALPRFLAEP 241
Cdd:COG0738 162 SWHLPYLILAVLLLLLAL-LFLRSKLPEIEEEEEEAA----------------GSAASLKSLLKNPRLLLGGLAIFLYVG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 242 AWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLpplfqrwfgVNLIVSRKMVVTMGALLMIGPGMIGL 321
Cdd:COG0738 225 AEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFL---------LKRFGPVRLLRLSALLAAVGLLLALL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 322 FTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAwLASTMFALVVGALADTIGFSPLFAVLAVFD 401
Cdd:COG0738 296 APGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLADAFGLRAAFLVPLVCY 374
|
410
....*....|....*..
gi 2095916352 402 LLGALVIWTVLKNKPAD 418
Cdd:COG0738 375 LLILLLALALKRKRRKK 391
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
11-409 |
1.28e-24 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 104.62 E-value: 1.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 11 MIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCG 90
Cdd:cd17318 22 IVAMVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 91 STALA--GSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFI 168
Cdd:cd17318 102 LTPLAarGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFY 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 169 ISGVLSFAWAIAWLIFYkhprdqkklsdeerdyiiggqesqhqtnnakkmspwqilrnRQFWGIALPRFLAEPAWGTFNA 248
Cdd:cd17318 182 IFGGLGLLWCLLWFFLV-----------------------------------------LPVWAIVVAHFGHNWGFYTLLT 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 249 WIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMG----ALLMIGPGMIGlfTS 324
Cdd:cd17318 221 ELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKLFTSIGflgpGVFLIALGYLG--SN 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 325 PYVAIALLCI----GGFAHQALSGALITLSSDVFGrnevaTANGLTGMAAWLASTMFALVVGAL---ADTIG-FSPLFAV 396
Cdd:cd17318 299 ATLAVVFLTLsvglSGACYSGFLVNHLDLAPNYAG-----TLMGITNTAATIAGIISPLIVGAIvknDQTIGqWRIVFFI 373
|
410
....*....|...
gi 2095916352 397 LAVFDLLGALVIW 409
Cdd:cd17318 374 SAAIYILGAIFYL 386
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
8-406 |
2.48e-23 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 101.16 E-value: 2.48e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAI 87
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 88 FCGSTALAGSWGG----LALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM--- 160
Cdd:cd17345 81 INILIGFVPSATSsvglMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIfgd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 161 HSWQMAFIISGVLSFAWA-IAWLIFYKHPRDQKKLSDEE--RDYIiggqESQHQTNNAKKMSPWQI-----LRNRQFWGI 232
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAvIVLFLGKDTPESEGLPPIEEykGDYP----EEADGEEEEQELSAWEIfvkyvLKNKLLWYI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 233 ALPR-FLAEPAWGTFNaWIPLFMFKVYGFNLKE----IAMFAWMpmlfADLGCIVGGYLPPLFQRwfgvnlivSRKMVVT 307
Cdd:cd17345 237 AIANvFVYLVRYGILD-WAPTYLSEVKGFSKAQamwaFSLFEWA----AIPGTLLAGWLSDKLFK--------GRRAPTG 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 308 MGALLMIGPGMIGLFTSPYV---AIALLCIGG--FAHQALSGALITlssDVFGRNEVATANGLTGMAAWLASTMFA-LVV 381
Cdd:cd17345 304 IIFMILVIVALIVYWLAPNVlvdLIALIALGFliYGPVMLIGLQAL---ELVPKKAAGTAAGLTGLFGYLGGSVLAtALI 380
|
410 420
....*....|....*....|....*
gi 2095916352 382 GALADTIGFSPLFAVLAVFDLLGAL 406
Cdd:cd17345 381 GIIVDHFGWNGGFIVLLASCILAII 405
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
13-385 |
1.15e-22 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 99.23 E-value: 1.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 13 ALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGST 92
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 93 ALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAppLVVWAIVMH---SWQMAFII 169
Cdd:cd17328 82 SFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLG--YVVGGLVAQatgGWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 170 SGVLSFAWAIAWLIFYKHPRdqKKLSDEERDyiiggqesQHQTNNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTFNAW 249
Cdd:cd17328 160 TGVLGVLLAILLLLFVREPP--RGAAEGGVM--------AKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFW 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 250 IPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLMI---GPGMIGLFTSPY 326
Cdd:cd17328 230 APTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAApflFLALVLALSNLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 327 VAIALLCIGGFAH-----------------------------------QALSGALITLSSDVFGRNEVATANGLTGMAAW 371
Cdd:cd17328 310 LAWVLLFLGEFLLslnwapvfaillyvviptrrstasaiqillshllgDAGSPYLIGLISDLLRQNKDSPLAEAASLQYA 389
|
410
....*....|....
gi 2095916352 372 LASTMFALVVGALA 385
Cdd:cd17328 390 LLLCSFVLVLGGFF 403
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
12-407 |
5.02e-22 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 96.85 E-value: 5.02e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGS 91
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 92 TALAGSWG--GLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFII 169
Cdd:cd17380 81 TPLLAYSSlpLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 170 SGVLSFAWAIAWLIFYkhprdqkklsdeerdyiiggqesqhqtnnakkmspwqilrnRQFWGIALPRFLAepAWGTFN-- 247
Cdd:cd17380 161 FGLLGLLWALVWLIYL-----------------------------------------PPVWAIIVAHFCM--NWGFYIll 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 248 AWIPLFmFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwFGVNLIVSRKMVVTMGallMIGPGM----IGLFT 323
Cdd:cd17380 198 SWLPTY-FHEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLIS-RGWTVTSVRKLMQSIG---FLGPALflllLSHTD 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 324 SPYVAIALLCIG-GFAHQALSGALITLsSDVFGRNEVATAnGLTGMAAWLASTMFALVVGALADTIG-FSPLFAVLAVFD 401
Cdd:cd17380 273 SFSLALLCMSVAlGLSAFSSSGVLVNH-QDIAPNYAGIVF-GISNTAGTIPGIVGVYLTGYILEATGsWSLVFVLAAVVN 350
|
....*.
gi 2095916352 402 LLGALV 407
Cdd:cd17380 351 LVGAVV 356
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-411 |
2.41e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 94.94 E-value: 2.41e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGS 91
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 92 TALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGaMIAPPLVVWAIVMHSWQMAFIISG 171
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLG-IAVGPLLGGLLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 172 VLSFAWAIAWLIFYKHPRdqkklsdeerdyiiggqESQHQTNNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIP 251
Cdd:cd17474 160 ALIPVAFLAILFLLPEPK-----------------EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 252 LFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFqrwfgvnliVSRKMVVTMGALLM-IGPGMIGLFTSPYVAIA 330
Cdd:cd17474 223 FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR---------FGARRILVIGLLLYaLSLLLLGFVPSLALLLI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 331 LLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGALVIWT 410
Cdd:cd17474 294 AIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
.
gi 2095916352 411 V 411
Cdd:cd17474 374 L 374
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
8-412 |
6.42e-21 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 93.49 E-value: 6.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAI 87
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 88 FCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 168 IISGVLSFAWAIawlIFYKHPRDqkklsdeerdyiiggqesqhqtnnakkmSPWQIlrnrqfWGIALPRFLAEPAWGTFN 247
Cdd:cd17312 161 LVPGIVGLVVAI---ILFFFLRD----------------------------SPPYV------WVLSLAYAFVYIVRYACL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 248 AWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPplfQRWFGVNlivSRKMVVTMGALLMIGPGMIGLF-TSPY 326
Cdd:cd17312 204 DWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLS---DKLFGGR---RAPIAVIYMLLMTLSLALFWFFpHNKL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 327 VAIALLCIGGFAHQALSGALITLSSDVFGRNEVA-TANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGA 405
Cdd:cd17312 278 LSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAgTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSV 357
|
....*..
gi 2095916352 406 LVIWTVL 412
Cdd:cd17312 358 LLLLSLW 364
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
49-388 |
1.05e-20 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 94.04 E-value: 1.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 49 YIIAAYSAAYTVMQPVAGYVLDILGTK--VGYAFFAIAWAIFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEW 126
Cdd:TIGR00894 80 LILSSHFYGQIIIQIPVGYLAGKYVFKwsIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 127 FPAKERSIAVGYFNVGSSIGAMIAPPLVVW-AIVMHSWQMAFIISGVLSFAWAIAWLIF-YKHPRDQKKLSDEERDYIig 204
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWlCESWGGWPMIFYVFGIVGCAWSLLWFVFpADDPSIHPCISKFEKKYI-- 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 205 GQESQHQTNNAKKMSPWQ-ILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVG 283
Cdd:TIGR00894 238 NSSLQGQKGSTRQSLPIKaIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFA 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 284 GYLPPLFQRWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSP--YVAIALLCI-GGFAHQALSGALItLSSDVFGRneva 360
Cdd:TIGR00894 318 GYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAafYLTIIILTLaNAVSSGPLAGVLI-NSLDLAPR---- 392
|
330 340
....*....|....*....|....*...
gi 2095916352 361 tANGLTGMAAWLASTMFALVVGALADTI 388
Cdd:TIGR00894 393 -FLGFIKGITGLPGFIGGLIASTLAGNI 419
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-409 |
4.65e-20 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 91.07 E-value: 4.65e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAVGAAEA 113
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFawAIAWLIFYKHPRDQkk 193
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL--LAALLLWRLLPSLP-- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 194 lsdeerdyiiggqeSQHQTNNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFawmpM 273
Cdd:cd17324 179 --------------PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL----L 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 274 LFADLGCIVGGylpPLFQRWfgVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDV 353
Cdd:cd17324 241 LLFGVAGVVGS---PLAGRL--ADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2095916352 354 FGRNeVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17324 316 APEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
16-409 |
1.67e-19 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 89.60 E-value: 1.67e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 16 TLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALA 95
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 96 GSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGY----FNVGSSIGAMIAPPLVvwaiVMHSWQMAFIISG 171
Cdd:cd17475 82 GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIrqtgVPLGGALAAALLPPLA----LHYGWRAAFVVAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 172 VLSFAWAIAWLIFYKHPRDQKklsdeerdyiiggqeSQHQTNNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIP 251
Cdd:cd17475 158 LVSILAAVLFWLFYREPPAAS---------------AATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 252 LFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPplfQRWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYVAIAL 331
Cdd:cd17475 223 LFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVS---DRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2095916352 332 LCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALAD-TIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17475 300 LILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDaTHSYAPAWLALALLLVLAALLLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-418 |
9.02e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 87.62 E-value: 9.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAI 87
Cdd:COG2807 16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 88 FCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:COG2807 96 GLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 168 IISGVLSFAWAIAWLIFYKHPRdqkklsdeerdyiiggqesQHQTNNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTFN 247
Cdd:COG2807 175 AVWALLALLALLLWLPLLRRRP-------------------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 248 AWIPLfMFKVYGFNLkeiAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVnlivsRKMVVTMGALLMIGPGMIGLF--TSP 325
Cdd:COG2807 236 AWLPP-ILRDAGLSA---ATAGLLLSLFQLAGIPGSLLVPLLADRLGDR-----RPLLLLLGLLGLAGLLGLLLApgSLP 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 326 YVAIALLCIGGFAHQALSGALITLSSDvfGRNEVATANGLTGMAAWLASTMFALVVGALAD-TIGFSPLFAVLAVFDLLG 404
Cdd:COG2807 307 WLWAVLLGLGQGGLFPLALTLIGLRAR--TPAEAAALSGMAQSVGYLLAALGPLLVGALHDaTGSWTAALLLLAALAVLM 384
|
410
....*....|....
gi 2095916352 405 ALVIWTVLKNKPAD 418
Cdd:COG2807 385 LVAGLLAGRPYVED 398
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
29-409 |
1.11e-18 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 86.84 E-value: 1.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 29 VAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAV 108
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 109 GAAEAAMIPAGLKASSEwFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIV---MHSWQMAFIISGVLSFAWAIAWLIFY 185
Cdd:cd17478 95 GIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVAlfgGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 186 KHPRDQKKLSDEERDYIIggqesqhqtnnaKKMSPWQILrnrqfWGIALPRFLAEPAWGTFnawIPlFMFKVYGFNLKEI 265
Cdd:cd17478 174 KPEAKKAAAKSSARSTLK------------GVWRALLLL-----LIIVFLRSWVLSSLTTF---LP-FYLVQRGYSLVFA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 266 AMFAWMPMLFADLGCIVGGYLPPLFqrwfgvnlivSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQALSGA 345
Cdd:cd17478 233 GLLLSLFLFAGAIGTLIGGPLSDRF----------GRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPV 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095916352 346 LITLSSDVFGRNeVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17478 303 TVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
9-370 |
2.47e-18 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 86.53 E-value: 2.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 9 WYMIALVTLGTVLGYLTRNTVAAAAPTLM-EELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAI 87
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMGMkEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 88 FCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIApPLVVWAIV-------M 160
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG-GLLAYGVFkilgvggL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 161 HSWQMAFIISGVLSFAWAIAwlIFYKHPRDQKK---LSDEERDYIIGGQESQHQTNNAKKMSPWQI---LRNRQFWGIAL 234
Cdd:cd17327 163 AGWRWLFIIEGLITIIIGLV--IFFWLPDNPSKawfLTEEEKELAVERLRANQTGKGDQKFKWKQIkeaFKDPRTWLLFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 235 PRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQrwfgvnlivsRKMVVTMGALLMI 314
Cdd:cd17327 241 FFFCSQITNNGISNFLPLIL-KSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFK----------KRGLFAIFACVLA 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095916352 315 GPGMIGLFTSP-----YVAIALLCIGGFAHQALSGALItlSSDVFGRNEVATANGLTGMAA 370
Cdd:cd17327 310 LVGSIILLAAPnppgaYFAAYILGGGSYAGFPILLSWI--SSNCAGYTKRATVLAIMLIFY 368
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-179 |
2.68e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 76.00 E-value: 2.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAI 87
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 88 FCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170
....*....|..
gi 2095916352 168 IISGVLSFAWAI 179
Cdd:COG0477 172 LINAPLGLLALV 183
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
14-410 |
5.17e-15 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 76.14 E-value: 5.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 14 LVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFC-GST 92
Cdd:cd17341 3 LSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLlALA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 93 ALAGSWGGLALARGAVGAAeAAMIPAGLKASSEWFPAKER----SIAVGYFNVGSSIGAMIAPPLVVWAIVMHS---WQM 165
Cdd:cd17341 83 LAVSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIggaaGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGfvgWRN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 166 AFIISGVLSFAWAIAWLIFYKHPrDQKKLSDEERDYIIggqesqhqtnnakkmspWQILRNRQFWGIALPRFLAEPAWGT 245
Cdd:cd17341 162 AFFVPGILLAIAAVLVLLFGDDL-PTGKASALEFLKVQ-----------------LAVLKNYRTWILSLLYGVTFGSFVG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 246 FNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLF--QRWFGVNLIVsrkMVVTMGALLMIGPGMIGLFT 323
Cdd:cd17341 224 FSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFggRRRLWWLFIV---MTIGAALLSLSLPTSGTNLV 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 324 spyVAIALLCIGGFAHQALSGALITLSSDVFgRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPL-FAVLAVFDL 402
Cdd:cd17341 301 ---LFLALFVALGLGAGAGNGSVFRMVPFIF-RRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGaFSLFGVLAV 376
|
....*...
gi 2095916352 403 LGALVIWT 410
Cdd:cd17341 377 ACTLLVWL 384
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
15-409 |
2.16e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 74.17 E-value: 2.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 15 VTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTAL 94
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 95 AGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLS 174
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 175 F-AWAIAWLIFYKHPRdqkklsdeerdyiiggqesqHQTNNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLF 253
Cdd:cd17489 161 LlALLLVFLVKDPPPV--------------------AAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 254 MFKVygfNLKEIAMFawmpMLFADLGCIVGGYLPPLFQRWFGvnlivsRKMVVTMGALLM-IGPGMIGLFTSPYVAIALL 332
Cdd:cd17489 221 AAER---GISNAGLF----FTVYAIALLLSRPFSGKLSDRKG------PKTVIIPGLLLLaLGLLLLSFAGSPWMLLLAA 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2095916352 333 CIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17489 288 VLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
8-411 |
1.09e-13 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 72.26 E-value: 1.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAI 87
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 88 FCGSTALAGSWGGLALARGAVGAAEAAMIPAG-LKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMA 166
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITpVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 167 FIISGVLSFAWAIAWLIFYKHPRDQKKLSDEERDyiiggqeSQHQTNNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTF 246
Cdd:cd17353 160 FLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPL-------ANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLML 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 247 NAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFqrwfgvnlivSRKMVVTMgALLMIGPGMIGLFTSPY 326
Cdd:cd17353 233 IGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI----------GRKNTLSI-AFLIQGVAMFLLPFIGS 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 327 VAIALL---CIGGFAHQALSGALITLSSDVFGRNEVATANGLTgMAAWLASTMFA-LVVGALADTIGFSPLFAVLAVFDL 402
Cdd:cd17353 302 VAVLFVlgvALIGFCYGGGFALFPALTADFFGTKNAGTNYGLL-YTAKGVGGLIGpIIAAYVLYTGGYNAAFIIAAALSL 380
|
....*....
gi 2095916352 403 LGALVIWTV 411
Cdd:cd17353 381 VALALALLL 389
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-412 |
1.11e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 71.82 E-value: 1.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 15 VTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK----VGYAFFAIAWAIfcg 90
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKrvflIGLALFGLASLL--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 91 sTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIIS 170
Cdd:cd17321 78 -CALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 171 GVLSfawAIAWLIFykhprdqkklsdeerdyiiggqesqhqtnnakkmspwqilrnRQFWGIALPRFLAEPAWGTFNAWI 250
Cdd:cd17321 157 VPIG---LVALLLA------------------------------------------RTFSGAVLAAFLLGAALGGLLFLL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 251 PLFMFKVYGFNLKEIAMFawmpMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLMIgpGMIGLFTSPYVAIA 330
Cdd:cd17321 192 PLYLQGVLGYSPLQAGLA----LLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLL--ALLGADSSVWLLLP 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 331 LLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMA-------------AWLASTMFALVVGALADTI--------- 388
Cdd:cd17321 266 GLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTArqlggalgvallgALLTAGLSANLGDSGVAALlsaaaaafa 345
|
410 420
....*....|....*....|....*
gi 2095916352 389 -GFSPLFAVLAVFDLLGALVIWTVL 412
Cdd:cd17321 346 aGFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
36-411 |
6.71e-13 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 69.61 E-value: 6.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 36 LMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAVGAAEAAM 115
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 116 IPAGLKAS-SEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAI-AWLIFYKHPRDQKK 193
Cdd:cd17355 109 LAAVAFATvAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVpVLLLLRRRPADLAL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 194 LSDEERDYIIGGqesqhqtnnakkMSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPM 273
Cdd:cd17355 189 RAYDDASPASPG------------STLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL-ADRGISPAAAAVALALIG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 274 LFADLGCIVGGYlppLFQRWFgvnlivSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIG-GFAHQALSGALITLSSD 352
Cdd:cd17355 256 LFNIVGRLLSGW---LGDRYS------PRRLLAASYALRALGLALLLLLPFPPLALLLFAALfGLGWGATVPLTAALAAR 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 353 VFGRNEVATANGLTGMAAWLASTMFALVVGALADTIG-FSPLFAVLAVFDLLGALVIWTV 411
Cdd:cd17355 327 YFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-176 |
2.23e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 67.99 E-value: 2.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 15 VTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKvgyAFFAIAWAIFCGST-- 92
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTR---RLFLTALALFTLGSll 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 93 -ALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIIS- 170
Cdd:cd17503 78 cGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINl 157
|
....*...
gi 2095916352 171 --GVLSFA 176
Cdd:cd17503 158 piGILALL 165
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-409 |
2.03e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 64.93 E-value: 2.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 12 IALVTLGTVLGYLTRNTVAAAAPTLMEE--LHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFC 89
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 90 GSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPpLVVWAIVMH-----SWQ 164
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAA-LVASLLIPLlsgdwGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 165 MAFIISGVLSFawaIAWLIFykhprdqkklsdeerdyiiggqesqhqtnnakkmspwqilrnRQFWGIALPRFLAEPAWG 244
Cdd:cd17316 160 ILFLIGALPAL---LALLLR------------------------------------------RRTLLLILLWFFISFGYY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 245 TFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYlppLFQRWfgvnlivSRKmVVTMGALLMIGPGMIGLF-- 322
Cdd:cd17316 195 GLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGL---LSDRI-------GRK-KTLVIGLILSGILALPLFyl 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 323 --TSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVF 400
Cdd:cd17316 264 lsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILAL 343
|
....*....
gi 2095916352 401 DLLGALVIW 409
Cdd:cd17316 344 LAIVALIVA 352
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
7-185 |
4.66e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.13 E-value: 4.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 7 LRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEEL-HISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAW 85
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 86 AIFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQM 165
Cdd:cd17325 276 AVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT 355
|
170 180
....*....|....*....|
gi 2095916352 166 AFIISGVLSFAWAIAWLIFY 185
Cdd:cd17325 356 PFLAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
225-428 |
8.26e-11 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 63.36 E-value: 8.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 225 RNRQFWGIALPRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvnlivsRKM 304
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLA-EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGP---------RRV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 305 VVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGAL 384
Cdd:COG2223 73 LLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2095916352 385 ADTIGFSPLFAVLAVFDLLGALVIWTVLKNKPADDDTPPLSSRK 428
Cdd:COG2223 153 IAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR 196
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
10-386 |
1.88e-10 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 62.37 E-value: 1.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 10 YMIALVTLGTVlgYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAI-- 87
Cdd:PRK09556 31 YLVVFIGYLTM--YLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAIcm 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 88 --FCGSTALAGSWGGLALA-RGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVW-AIVMHSW 163
Cdd:PRK09556 109 lgFGASLGSGSVSLGLMIAlWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWgANYFFDG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 164 QMA--FIISGVLSFAWAIaWLIFYKHPrDQKKLSDEERDYIIGGQESQHQTN-NAKKMSPWQI-----LRNRQFWGIALP 235
Cdd:PRK09556 189 HVIgmFIFPSIIALIIGF-IGLRYGSD-SPEELGWGKAEEIFGEPISEEDKEtESTDMTKWQIfveyvLKNPVIWLLCFA 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 236 RFLAEPAWGTFNAWIPLFMFKVYGFNlKEIAMfawMPMLFADLGCIVG----GYLPplfqrwfgvNLIVSRKMVVTMGAL 311
Cdd:PRK09556 267 NIFLYIVRIGIDNWSPVYAFQELGFS-KEDAI---NTFTLFEIGALVGsllwGWLS---------DLANGRRALVACIAL 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 312 LMIGpGMIGLF---TSPYVAIALLCIGG---FAHQALSG-ALITLSSdvfgRNEVATANGLTGMAAWLASTMFALV-VGA 383
Cdd:PRK09556 334 ALII-FTLGVYqhaTSEYMYLASLFALGflvFGPQLLIGvAAVGFVP----KKAIGVANGIKGTFAYLFGDSFAKVgLGM 408
|
...
gi 2095916352 384 LAD 386
Cdd:PRK09556 409 IAD 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-189 |
1.43e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 59.50 E-value: 1.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 9 WYMIALVTLGTVLGYLTRNTVAAAAPT-LMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILG--TKVGYAFFAIAW 85
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 86 AIFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQM 165
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|....
gi 2095916352 166 AFIISGVLSFAWAIAWLIFYKHPR 189
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
15-400 |
1.80e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 58.73 E-value: 1.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 15 VTLGTVLGYLTRNTVAAAAPTLMEELHiSTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVgyaFFAIAWAIFC-GS-- 91
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKW---VLLIAIVIFElGSll 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 92 TALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAmIAPPLVVWAIVMH-SWQMAFIIS 170
Cdd:cd17502 77 CGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIAS-VAGPLIGGAFTDHlSWRWCFYIN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 171 ---GVLSFAwaiawlifykhprdqkklsdeerdyIIggqesqhqtnnakkmspwqilrnRQFWGIALPRFLAEPAWGTFN 247
Cdd:cd17502 156 lpiGGLALA-------------------------LL-----------------------RTILLSSIFGFLFGGALFGLI 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 248 AWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYlppLFQRWFGV-NLIVSRKMVVTMGALLMIgpgMIGLFTSPY 326
Cdd:cd17502 188 YYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGA---LISKTGRYkPLIVIGTILMSVGAGLLT---TLTLDTSKW 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095916352 327 VAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGltgmAAWLASTMFALVVGALADTIGFSPLFAVLAVF 400
Cdd:cd17502 262 LLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATA----TNTFFRSLGGTLGVAITDVFLVALALAALAFL 331
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
38-410 |
2.66e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 58.39 E-value: 2.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 38 EELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAVGAAEAAMIP 117
Cdd:cd17329 28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 118 AGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWaIVMHSWQMAFIISG---VLSFAWAIAWLIFYKHPRDQKKL 194
Cdd:cd17329 108 ASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGL-LLLYSFRLLFLAAAvlfLLAALVLLFLLPETRPKRRAAEK 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 195 SDEERDYiiggqesqhqtnnakkmspWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKeiaMFAWMPML 274
Cdd:cd17329 187 TEILRGY-------------------KIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES---LLGLLLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 275 FADLGCIVGGYLPPLFQRWfgvnlivSRKMVVTMGALLM-IGPGMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDV 353
Cdd:cd17329 245 NALLIVLLQFPVARLVERF-------RLRKILMIGILLFaIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAAL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2095916352 354 FGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGALVIWT 410
Cdd:cd17329 318 APPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
30-364 |
1.88e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 56.21 E-value: 1.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 30 AAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAVG 109
Cdd:TIGR00895 37 GFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 110 AAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAIAWLIFYKHPR 189
Cdd:TIGR00895 117 LGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESI 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 190 D--QKKLSDEERDYIIGGQESQHQtnNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFM--FKVYGFNlkei 265
Cdd:TIGR00895 197 DflVSKRPETVRRIVNAIAPQMQA--EAQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMllVGVYFLT---- 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 266 amfAWMPMLFADLG------------CIVGGYLPPLFqrwFGVNLIVSRKMVVTMGALL--MIGPGMIGLFTSPYVAIAL 331
Cdd:TIGR00895 271 ---NWLPKLMVELGfslslaatggalFNFGGVIGSII---FGWLADRLGPRVTALLLLLgaVFAVLVGSTLFSPTLLLLL 344
|
330 340 350
....*....|....*....|....*....|...
gi 2095916352 332 LCIGGFAHQALSGALITLSSDVFGRNEVATANG 364
Cdd:TIGR00895 345 GAIAGFFVNGGQSGLYALMALFYPTAIRATGVG 377
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
32-410 |
2.88e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 55.31 E-value: 2.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 32 AAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLD-------ILGTKVGYAFFAIAWAIFcGSTALAGSWGGLALA 104
Cdd:cd06173 21 ALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADrfdrrrlLILADLLRALLAAVLALL-ALLGSLSLWLLLVLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 105 rGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSF--AWAIAWL 182
Cdd:cd06173 100 -FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLlsALLLLFI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 183 IFYKHPRDQKKLSDEERDYIIGGqesqhqtnnakkmspWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNL 262
Cdd:cd06173 179 RRPPPAAPGESSSLLLRDLREGL---------------RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 263 keiAMFAWMPMLFAdLGCIVGGYLPPLFQRWFGvnlivSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQAL 342
Cdd:cd06173 244 ---AGYGLLLAAFG-VGALLGALLLGRLSKRRR-----RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLF 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2095916352 343 SGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGALVIWT 410
Cdd:cd06173 315 NVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
218-426 |
6.03e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.21 E-value: 6.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 218 MSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvn 297
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIA-ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGR----- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 298 livsRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMF 377
Cdd:COG2814 75 ----RRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 2095916352 378 ALVVGALADTIGFSPLFAVLAVFDLLGALVIWTVLKNKPADDDTPPLSS 426
Cdd:COG2814 151 PLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS 199
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-182 |
8.04e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 53.76 E-value: 8.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 9 WYMIALVTLGTVLGYLTRNTVAAAAPTLMEE-LHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAI 87
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 88 FCGSTALAGSWGGLALARGAVGAAEAAMIPAGL--KASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIV-MHSWQ 164
Cdd:cd17316 256 LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGAlyAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAsTGGTG 335
|
170
....*....|....*...
gi 2095916352 165 MAFIISGVLSFAWAIAWL 182
Cdd:cd17316 336 VPALILALLAIVALIVAL 353
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
12-184 |
2.34e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 52.58 E-value: 2.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGS 91
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 92 TALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISG 171
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170
....*....|...
gi 2095916352 172 VLSFAWAIAWLIF 184
Cdd:cd17323 161 IISGFCLILIFLF 173
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
49-391 |
2.43e-07 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 52.47 E-value: 2.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 49 YIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGG--LALARGAVGAAEAAMIPAGLKASSEW 126
Cdd:cd17381 69 WILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAgyLIAVRALEGLGEGVTFPAMHAMWASW 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 127 FPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAIAWLIFYkhprdqkklsdeerdyiiggq 206
Cdd:cd17381 149 APPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV--------------------- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 207 esqhqtnnakkmspwqilrnRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYL 286
Cdd:cd17381 208 --------------------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 287 PPLFQRWFGVNLIVSRKMVVTMGallMIGPGM----IGLFTSPYV-AIALLCIggfahqalSGALITLSSDVFGRNEVAT 361
Cdd:cd17381 268 ADNLREKQNFSTVCVRKIFTLIG---MIGPAVfllaAGFTGCNYSlAVAFLTI--------SSTLGGFSASGFNINHLDI 336
|
330 340 350
....*....|....*....|....*....|
gi 2095916352 362 ANGLTGMAAWLASTmFALVVGALADTIGFS 391
Cdd:cd17381 337 APSYAGILLGITNT-FATIPGMVGPVIAKS 365
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-192 |
2.54e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.58 E-value: 2.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 8 RWYMIALVTLGTVLGYLTrntVAAAAPT-LMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILG-TKVGYAFFAIAW 85
Cdd:COG2223 206 RFWLLSLLYFGTFGSFIG---FSSWLPPyLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGgRRVLLIVFALMA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 86 AIFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM-HSWQ 164
Cdd:COG2223 283 LGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtGSYT 362
|
170 180
....*....|....*....|....*...
gi 2095916352 165 MAFIISGVLSFAWAIAWLIFYKHPRDQK 192
Cdd:COG2223 363 AAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
35-271 |
3.28e-07 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 51.92 E-value: 3.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 35 TLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAG-SWGGLALARGAVGAAEA 113
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVqSYSVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 114 AMIPAgLKASSEWFPAKER----SIAVGYFNVGSSIGAMIAPPLVVWAI------VMHSWQMAFIIsGVLSFAWAIAWLI 183
Cdd:TIGR00886 107 SFASC-MPWISFFFPKKIQgtalGLAAGWGNMGGGVAQFVMPPIIGSLIfgggqpAHLAWGWAFVI-VPAGILLLPALLI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 184 FY---KHPRDQKKlsdeerdyiiggqesqhqTNNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGF 260
Cdd:TIGR00886 185 FFvgaDTPPGKPA------------------TGKLSFKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGL 246
|
250
....*....|.
gi 2095916352 261 NLKEIAMFAWM 271
Cdd:TIGR00886 247 SKVQAGAYASL 257
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
48-412 |
3.87e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.81 E-value: 3.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 48 SYIIAAYSAAYTVMQPVAGYVLDILGTKvgyAFFAIAWAIFcgstALAGSWGGLA-------LARGAVGAAEAAMIPAGL 120
Cdd:cd17473 38 PLLLTLPALFIALFAPLAGWLADRFGRK---RLLIAGLLLY----GIGGVAGLFLdslyallASRALLGIGVAGIMTLAT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 121 KASSEWFPAKERSIAVGYFNVGSSIGAMIApPLVVWAIVMHSWQMAFIISGvLSFAWAIAWLIFYKHPRDQKKlsdeerd 200
Cdd:cd17473 111 ALIGDYFEGEERAKMLGLQSAAMSLGGVVF-LLLGGALAEIGWRAPFLVYL-LALPVLILVLLFLPEPARKSK------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 201 yiiggqesqhqTNNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFAdlgc 280
Cdd:cd17473 182 -----------SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAG---- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 281 IVGGYLPPLFQRWFGVnlivsRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVA 360
Cdd:cd17473 247 AIGALLFGRLKRRLGK-----RRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2095916352 361 TANGLTGMAAWLASTMFALVVGALADTI-GFSPLFAVLAVFDLLGALVIWTVL 412
Cdd:cd17473 322 RAMGIVTSAFFLGQFLSPLVLGPLVNLTgGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
3-184 |
4.79e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.42 E-value: 4.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 3 KIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHI-STQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFF 81
Cdd:cd17473 190 TAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 82 AIAWAIFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM- 160
Cdd:cd17473 270 FALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLt 349
|
170 180
....*....|....*....|....
gi 2095916352 161 HSWQMAFIISGVLSFAWAIAWLIF 184
Cdd:cd17473 350 GGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
12-409 |
5.68e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 51.42 E-value: 5.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK----VGYAFFAIAwAI 87
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRpvllAGLLLFILA-SL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 88 FCgstALAGSWGGLALAR---GAVGAAEAAMIPAGLKASsewFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQ 164
Cdd:cd17320 80 LC---ALASSIEQLLIARflqGLGAAAGSVVARAIVRDL---YSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 165 MAFIISGVLSFAWAIAWLIFYKHPRDQKKLSDEERDYIIGGQEsqhqtnnakkmspwqILRNRQFWGIALPRFLAEPAWG 244
Cdd:cd17320 154 AIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKR---------------VLKNRRFLGYALALGLSFAGLF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 245 TFNAWIPLFMFKVYGFNlkeIAMFAWMpMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTS 324
Cdd:cd17320 219 AYLAAAPFIYIEQLGLS---PAQFGLL-FALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 325 PYVAIALLCIGGFAHQALSGALITLSSDVFGRnEVATANGLTGMAAWLASTMFALVVGALADTiGFSPLFAVLAVFDLLG 404
Cdd:cd17320 295 LWPLVAPLFLIFFGFGLIFPNATSLALEPFPH-VAGTASALLGFLQFLIGALAGALVGLLPNG-TALPMGLLILVLGLLA 372
|
....*
gi 2095916352 405 ALVIW 409
Cdd:cd17320 373 LLLLI 377
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
127-409 |
6.11e-07 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 51.07 E-value: 6.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 127 FPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFI-ISGVLSFAWAIAWLIfykhprdqkklsdeeRDYIIGG 205
Cdd:cd17485 121 LTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSLLLsLAALYLLLLLPVLFL---------------RELELPQ 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 206 QESQHQTNNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKvYGFNLKEIAM-FAWMPMLFADLGCIVGG 284
Cdd:cd17485 186 QPPASERGAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVD-RGFSLSQIGLlSGVGGSLVSIAGSLLGG 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 285 YLpplFQRWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANG 364
Cdd:cd17485 265 YL---LKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWVLLLASLALLHLVGGMITTALFTLMMDCSQQAQAGTDYT 341
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2095916352 365 LTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17485 342 LLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
8-406 |
1.07e-06 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 50.48 E-value: 1.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAI 87
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 88 FCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 168 IISGVLSFAWAIaWLIFykhprdqkKLSDeerdyiiggqesqhqtnnakkmspwqilRNRQFWGIALPRFLAEPAWGTFN 247
Cdd:cd17488 161 YVPGIIAILMGI-VLCW--------RLRD----------------------------RPPYIWLLAFCYVLVYVVRTAIN 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 248 AWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLF---QRWfGVNLIVSRKMVVTMGALLMIGPGMIGLfts 324
Cdd:cd17488 204 DWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLfkgNRG-PMNLIFALGLLVSVGALWLVPVHSYWL--- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 325 pyVAIALLCIGGFAHQalSGALITLSSDVFGRNEVA-TANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLL 403
Cdd:cd17488 280 --LATCFFTIGFFVFG--PQMLIGMAAAECSHKDAAgSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAI 355
|
...
gi 2095916352 404 GAL 406
Cdd:cd17488 356 SGL 358
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
65-408 |
1.17e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 50.38 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 65 AGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSS 144
Cdd:cd17371 54 GGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 145 IGAMIA----PPLVVWAIVMHSWQMAFIISGVLSFawaIAWLIfykhprdQKKLSDEERdyiigGQESQHQTNNAKKMSP 220
Cdd:cd17371 134 VGWLLAtllaALLFPLLPPEIAWRVLFLLGALPAL---LVLFI-------RRFVKEPPQ-----WQAARAARRHFADRPS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 221 WQILRNRQFWGIALPRFL----AEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgv 296
Cdd:cd17371 199 LRELFSPPLLRTTLLASLlatgALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGR---- 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 297 nlivsRKMVVTMGALLMIG-PGMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLAST 375
Cdd:cd17371 275 -----RNNFALFALGSAISiLLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGA 349
|
330 340 350
....*....|....*....|....*....|...
gi 2095916352 376 MFALVVGALADTIGFSPLFAVLAVFDLLGALVI 408
Cdd:cd17371 350 LFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVL 382
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
60-409 |
1.18e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 60 VMQPVAGYVLDILGTKVGY-----AFFAIAWAIFCGSTALAGSWGG------LALARGAVGAAEAAMIPAGLKASSEWFP 128
Cdd:COG2211 61 ITDPLIGALSDRTRTRWGRrrpwiLIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 129 -AKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM------HSWQMAFIISGVLSFAwAIAWLIFYKHPRDQKKlsdeerdy 201
Cdd:COG2211 141 dYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaaLGYRLTALIFAVLGLL-AFLLTFFGTKERPVPE-------- 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 202 iiggqesqHQTNNAKKMSpWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLkeiAMFAWMPMLFAdLGCI 281
Cdd:COG2211 212 --------EEKVSLKESL-KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSA---ALVGLLLALYF-LAAL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 282 VGGYLPPLFQRWFGvnlivsRKMVVTMGALLMIGpGMIGLF----TSPYVAIALLCIGGFAHQALSGALITLSSDV---- 353
Cdd:COG2211 279 LGAPLWPRLAKRFG------KKKAFIIGLLLAAL-GLLLLFflgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdyd 351
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095916352 354 ---FGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSP---------------LFAVLAVFDLLGALVIW 409
Cdd:COG2211 352 ewkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaqspsaltgirllFFLLPAVLLLLAALLLL 425
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
9-408 |
1.36e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 50.32 E-value: 1.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 9 WYMIALVTLGTVLGYLTRNTVAaaaPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVG----------- 77
Cdd:cd17313 1 LFLLGFGFFGIEFGWALENSYV---PPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGrrrpfilvgap 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 78 ---YAFFAIAWA-IFCGSTALAGSWGGLALARGAVG----AAEAAMIPAglKA-SSEWFPAKERSIAVGYFN-------- 140
Cdd:cd17313 78 laaLGLILIPNAaDIGLALGDGPRTWALVLFVLGIVlldfAMNVCQGPV--RAlLPDLVPPEQRSKANGIINfmgglggv 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 141 VGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLsFAWAIAWLIFYkhprdqkklSDEERDYIIGGQESQHQTNNAKKMSP 220
Cdd:cd17313 156 LGYLLGAILWDHNWFGFALGGNLKVPFYIGAII-LLVCVLVTLFF---------VKEPPLSPEAGEHSENPSLGEVLKSL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 221 WQILRN--RQFWGIALPRFLAEPAWGTFNAWIPLFM-FKVYGFNLKEIA-------MFAWMPMLFAdLGCIVGGYLPPLF 290
Cdd:cd17313 226 LKLLKImpRSLLRLLLVIFFWWIAFFPFELFFTDYMgEEVYHGTSAASShygagvrMGAWGLLIFS-LAFLIFSLPIGKL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 291 QRWFGvnlivsRKMVVTMGALLM-IGPGMIGLFTSPYVAIALLCIGG---FAHQALSGALITLSSDVFGRNEvATANGLT 366
Cdd:cd17313 305 GKKIG------RKKVYLIGLVLFaVGMALMALVHNVTVALVLFALGGigwATININPYPLVSDYHSESGRGQ-GTDTGLL 377
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 2095916352 367 GMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGALVI 408
Cdd:cd17313 378 NLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGA 419
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
8-186 |
1.52e-06 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 50.03 E-value: 1.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK-------VGYAF 80
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARwlfssglVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 81 FAIAWAIFCGSTALAGSWGGLALARGAVGAAEAAMipagLKAsseWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM 160
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKI----LRK---WFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALS 153
|
170 180
....*....|....*....|....*.
gi 2095916352 161 HSWQMAFIISGVLSFAWAIAWLIFYK 186
Cdd:cd17343 154 YGWRSTLSISGTVAVVMSVVCLLFIK 179
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
237-422 |
1.59e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 1.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 237 FLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLpplfqrwfgVNLIVSRKMVVTMGALLMIGP 316
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRL---------SDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 317 GMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAV 396
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180
....*....|....*....|....*.
gi 2095916352 397 LAVFDLLGALVIWTVLKNKPADDDTP 422
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKP 182
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
29-173 |
1.70e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.89 E-value: 1.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 29 VAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAV 108
Cdd:cd17365 18 MGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLT 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2095916352 109 GAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVL 173
Cdd:cd17365 98 GLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVP 162
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
34-411 |
2.69e-06 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 49.14 E-value: 2.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARgAVGAAEA 113
Cdd:cd17331 24 PYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSR-LPSVFMH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 114 AMiPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFA-WAIAWLIfykhPRDQK 192
Cdd:cd17331 103 AM-QAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLsIVLVILL----IPSNT 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 193 KLSDEERDYIIGGQESQHQTNNAKKMspwqiLRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFawMP 272
Cdd:cd17331 178 KSKREKEAKESASPPSVFNLKEILRL-----LRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYL--MS 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 273 MLFAdLGCIVGGYLPPLFQRWFGvnlivSRKMVVTMGALLMIG-PGMIGLFTSP--YVAIALLCIGGFAHQALSGALITL 349
Cdd:cd17331 251 YAGV-LGMVVQGLLVGPLTKRFG-----ERSLLKLSVALLAIGyLLLAFVTTVWqlLVLLLPLVIGGSVLYTVITSLLTK 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095916352 350 SSDvfgRNEVATANGLTGMAAWLASTMFALVVGALADTIGFsPLFAVLAVFDLLGALVIWTV 411
Cdd:cd17331 325 AVP---PEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGF-PSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
24-356 |
5.32e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.09 E-value: 5.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 24 LTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK----VGYAFFAIAWAIFCGSTALAGSWG 99
Cdd:cd17333 10 LTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRrtliLGLLLISLALALIFATPSIYLFVV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 100 GLALARGAVGAAEAAMIPAGLKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIvmhSWQMAFIISGVLSFAWAI 179
Cdd:cd17333 90 LMFLAGLGAGILDTGANTFVGALFEESSATR-LNVLHGFFGLGALIGPLIATSLLTSEL---SWSWAYLIIGLIYLLLAI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 180 AWLIFYKHPRDQKKLSDeerdyiiggqesqhQTNNAKKMSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYG 259
Cdd:cd17333 166 LILLTLFPELPSARNPQ--------------QSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 260 FNLKEIAMFAWMPMLFADLGCIVGGYLpplfqrwfgVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAH 339
Cdd:cd17333 232 VSDGLAGYLLSGFWVGITIGRLLGGPI---------SRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFM 302
|
330
....*....|....*..
gi 2095916352 340 QALSGALITLSSDVFGR 356
Cdd:cd17333 303 AALFPTILSLGISNLPY 319
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
30-203 |
5.62e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 48.39 E-value: 5.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 30 AAAAPTLMEELHISTQqYSYIIAAYSAAYTVMQPVAGYVLDILGTK---VGYAFFAIAWAIFCGStalAGSWGGLALARG 106
Cdd:cd06179 18 AAVLPFIVADLGPSSN-STWISTAWSLAQAVLGPIVGRLSDLFGRRwffIGGNLLGVVGSIVAGT---AKSVNMLIGGQA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 107 AVGAAeAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPpLVVWAIVMH---SWQMAFIISGVLSFAWAIAWLI 183
Cdd:cd06179 94 LIGIG-AGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGP-LIAGALVEAnaaGWRWIFYINAIFNALALILLFF 171
|
170 180
....*....|....*....|
gi 2095916352 184 FYkHPRDQKKLSDEERDYII 203
Cdd:cd06179 172 FY-HPPPRPQLHGSSTRQKL 190
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
34-408 |
1.54e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.78 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAVGAAEA 113
Cdd:cd17477 20 SLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVvwAIVMHSWQMAFIISGVLSFAWAIAWLIFYKHPRDQKK 193
Cdd:cd17477 100 GLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLL--ALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 194 lsdeerdyiiggqesqhqtnnAKKMSPWQILRnrQFWGIALPRFLAEPAWGTFNAWIPLFMFKVyGFNLKEIAmfaWMPM 273
Cdd:cd17477 178 ---------------------AESISLRRLLR--IAPLALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAA---LLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 274 LFAdLGCIVG----GYLPPLFQRwfgvnlivSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQALSGALITL 349
Cdd:cd17477 231 AFV-LGGLLLqwplGWLADRFDR--------RRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALAL 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2095916352 350 SSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGALVI 408
Cdd:cd17477 302 AGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
37-182 |
1.69e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.77 E-value: 1.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 37 MEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK----VGYAFFAIAWAIFCGSTALAGSWGGLALARGAVGAAE 112
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKklliLGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 113 AAMipagLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAIAWL 182
Cdd:cd17370 306 SIE----RAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
29-180 |
2.15e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.42 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 29 VAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAV 108
Cdd:cd17504 15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQ 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095916352 109 GAAeAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAIA 180
Cdd:cd17504 95 GIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL 165
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
29-189 |
4.81e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 45.33 E-value: 4.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 29 VAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAV 108
Cdd:cd17476 17 VIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQ 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 109 GAAEAAMIPAGLKASSEWF-PAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAIAwLIFYKH 187
Cdd:cd17476 97 GLGPAFLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVA-AIFWTS 175
|
..
gi 2095916352 188 PR 189
Cdd:cd17476 176 PS 177
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
63-185 |
6.34e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.88 E-value: 6.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 63 PVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVG 142
Cdd:cd17317 43 LLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLF 122
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2095916352 143 SSIGAMIAPplvVWAIVMHSWQM-AFIISG----VLSFAWAIAWLIFY 185
Cdd:cd17317 123 WALGYMLLA---LLAYLIRDWRWlQLAISLpgllFLLLLWWLPRRTII 167
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
8-407 |
1.16e-04 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 43.94 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAI 87
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 88 FCGSTALAGSWGGLALARGA-VGAAEAAMIPAGLKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMA 166
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVfIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 167 FIISGVLsfAWAIAWLIFYKHPRDQKKLSDEErdyiiggqesqhQTNNAKKMSPWQILRNRQFWGIALPRFLaepawgTF 246
Cdd:cd17314 160 YTILGIL--AAIVLSVVSLLGFKEPPDNQARL------------HVQKKKTQTMGEIFRDKVFWILFIAIFL------VL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 247 NAWIPLFMFKV-YGFNLKEIAMFAWMPML-FADLGCIVGGYLPPLFQRWFGVNLivsRKMVVTMG-ALLMIGPGMIGLFT 323
Cdd:cd17314 220 IGGFLFIANMAsLVRSLQLDAPSFVTKLMsIYGLFNAFGRLLWGIVADFFGGRL---STLSILLTiLGLGLCAFLFLLKM 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 324 SPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALAD-TIGFSPLFAVLAVFDL 402
Cdd:cd17314 297 TPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDrTPSYISAVYIYAVIVF 376
|
....*
gi 2095916352 403 LGALV 407
Cdd:cd17314 377 LASAI 381
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
23-411 |
1.27e-04 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 43.80 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 23 YLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLD-ILGTKVG---YAFFAIAWAIFCGSTALAGSW 98
Cdd:cd17340 12 YFCYDNPAALQKQFIEDMDINTSQFMLLYSVYSWPNVVLCFFGGFLIDrVFGIRLGtiiFSLLVLIGQLIFALGALTNLF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 99 GGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIA----VGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF------- 167
Cdd:cd17340 92 WLMLVGRFIFGIGGESLAVAQNTYAVSWFKGKELNLVfglqLSFARIGSTVNFNVMPPIYKRISDFYSGYKSLgvalwig 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 168 IISGVLSFAWAIAWLIFykhprdqkklsDEERDYIigGQESQHQTNNAKKMSPWQILRNRqFWGIALPRFLAEPAWGTFN 247
Cdd:cd17340 172 AITCLFSLICAIILGLL-----------DKRAERI--LKKESNKTGEVIKLSDVKDFPLS-FWLICIICVFYYVAVFPFI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 248 AWIPLFMFKVYGFNLKEIAmfAWMPMLFadlgcIVGGYLPPLFQrwFGVNLIVSRKMVVTMGALLMIGPGMIGLFTS--P 325
Cdd:cd17340 238 GLGTVFFEEKYGFSPSEAA--AVNSIVY-----IISAAASPVFG--FLVDKVGRNILWVLIALVITLLGHLLLAFTFvnP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 326 YVAIallCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPL---FAVLAVFDL 402
Cdd:cd17340 309 LIAM---VIMGIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYLLLevfFIACLCVSL 385
|
....*....
gi 2095916352 403 LGALVIWTV 411
Cdd:cd17340 386 IALIILYLV 394
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
302-431 |
1.32e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 43.72 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 302 RKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVV 381
Cdd:cd17325 61 KRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLG 140
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2095916352 382 GALADTIGFSPLFAVLAVFDLLGALVIWTVLKNKPADDDTPPLSSRKPAT 431
Cdd:cd17325 141 GLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRS 190
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
34-409 |
1.78e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.30 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILG-----TKVGYAFFAIAWAIFcgstALAGSWGGLALAR--- 105
Cdd:cd17370 23 PLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkrkplVILGYGLSALAKPLL----ALAGSWQLVLLLRile 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 106 ----GAVGAAEAAMIpaglkasSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMH--SWQMAFIISGVLSFAwAI 179
Cdd:cd17370 99 rlgkGIRTPPRDALL-------ADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLggNYRTIFLLAAIPALL-AL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 180 AWLIFYKHPRDQKKLSDEERDYIIGGQesqhqtnnakkmspwqilRNRQFWGIALPRFLAepAWGTFNAWIPLFMFKVYG 259
Cdd:cd17370 171 LILLFVVKEYPRPPKLRKKSKKTSLKK------------------LPKAFWLYLLAVALF--ALGNFSFAFLILRAQELG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 260 FNLKEIAMFAWMPMLFADLGCIVGGYLpplFQRWfgvnlivSRKMVVTMGALLM-IGPGMIGLFTSPYVAIALLCIGGFA 338
Cdd:cd17370 231 LSAALIPLLYALFNLVYALAAYPAGRL---SDRI-------GRKKLLILGYLSLaLAYLGFALGSSLWLLLLGFILWGLY 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2095916352 339 HQALSGALITLSSDVFGRNEVATANGL----TGMAAWLAStmfaLVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17370 301 MGAQESIERAAVADLVPAELRGTAYGLfntvVGIGWLLAS----LIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
34-183 |
1.92e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 43.31 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLD--ILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAVGAA 111
Cdd:cd17352 207 PSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADkpRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFC 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2095916352 112 EAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM-HSWQMAFIISGVLSFAWAIAWLI 183
Cdd:cd17352 287 SGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYtGDYDAAFYFCGACLLLSGVLLFL 359
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
130-392 |
1.98e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 43.36 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 130 KERSIAVGYFNVGSSIGAMI----APPLVVWA---IVMHSWQMAFIISGVLSfawAIAWLIFYKHPRdqkklsdeERDYI 202
Cdd:cd17332 132 EERTSLTSWRMFFATIGGLLvtvlPPPLVAYFgggNASRGYFLTALIIGIIG---IILLLICFFGTR--------ERVVP 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 203 IGGQESQHQTnnakKMSPWQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFmfkvYGFNLKEIAMFAWMPMLFAdLGCIV 282
Cdd:cd17332 201 PEEEKSKLPL----LKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYY----FKYVLGGRAELVLLLLLIL-SGALL 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 283 GGYLPPLFQRWFGvnlivsRKMVVTMGALLMIgPGMIGLFTSPY----VAIALLCIGGFAHQALSGALITLSSDV----- 353
Cdd:cd17332 272 ALLPWPPLKKRFG------KKKAFFIGLLLAI-LGLLLLFFLPPgnlvLILVLAVLAGIGYGGANLLPWAMLADVidyge 344
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2095916352 354 --FGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSP 392
Cdd:cd17332 345 lkTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVA 385
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
36-175 |
5.21e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 42.15 E-value: 5.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 36 LMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVG------YAFFAIAWAIFCGSTALagswggLALARGAVG 109
Cdd:cd17352 29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVaiagglLAALGLLLSSFATSLWQ------LYLTYGVLG 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2095916352 110 AAEAAMI-PAGLKASSEWFpAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSF 175
Cdd:cd17352 103 GLGLGLIySPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCL 168
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-151 |
5.22e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 5.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 9 WYMIALVTLGTVLGYLTrntvaAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIF 88
Cdd:pfam07690 204 WLLLALLLFGFAFFGLL-----TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2095916352 89 CGSTALAGSWGGLALARGA---VGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAP 151
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLAlllLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
302-429 |
6.73e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.81 E-value: 6.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 302 RKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVV 381
Cdd:cd17489 61 KRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALG 140
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2095916352 382 GALADTIGFSPLFAVLAVFDLLGALVIWTVLKNKPADDDTPPLSSRKP 429
Cdd:cd17489 141 LFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAF 188
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
46-409 |
1.11e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.02 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 46 QYSYIIAAYSAAYTVMQPVAGYVLDILGTK----VGYAFFAIAWAIFcgstALAGSWGGLALARGAVGAAEAAmIPAGLK 121
Cdd:cd17330 35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKpvllLSLAGSAVSYVLL----GLSRNLWLLFLARFLDGLTGGN-VSVAQA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 122 ASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAIAWLIFYkhprdqkklsdeerdy 201
Cdd:cd17330 110 YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFL---------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 202 iiggqesqhqtnnakkmspwqilrnRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIamfAWMPMLFADLGCI 281
Cdd:cd17330 174 -------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQI---GLLLALVGIAGIL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 282 VGGYLPPLFQRWFGvnlivSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVAT 361
Cdd:cd17330 226 AQLLLIPRLAKRLG-----ERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGK 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2095916352 362 ANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGALVIW 409
Cdd:cd17330 301 AQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLS 348
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
86-182 |
1.17e-03 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 40.79 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 86 AIFCGST-------ALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAI 158
Cdd:cd17382 85 AIFVTSTlnmlipiAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILV 164
|
90 100
....*....|....*....|....
gi 2095916352 159 VMHSWQMAFIISGVLSFAWAIAWL 182
Cdd:cd17382 165 QYVGWSSPFYVYGVFGIIWYMFWM 188
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
34-191 |
2.29e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.98 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAVGAAEA 113
Cdd:cd06180 23 PLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMH-SWQMAFIISGVLSFAWA-IAWLIFYKHPRDQ 191
Cdd:cd06180 103 FVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGlSWRAGWLALALLSAVLLlLSFLLLRRGPSAP 182
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
300-423 |
2.58e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.84 E-value: 2.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 300 VSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIG-GFAHQALSGALITLSSDVFGRNEVATANGLTgMAAWLASTMFA 378
Cdd:cd17324 61 IERRRLLLVLLLLFILGNLLAALAPSFALLLLARALaGLAHGGFWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLG 139
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 2095916352 379 LVVGA-LADTIGFSPLFAVLAVFDLLGALVIWTVLKNKPADDDTPP 423
Cdd:cd17324 140 RPLGGlLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSL 185
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
302-411 |
3.39e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.41 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 302 RKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVV 381
Cdd:COG0477 79 KRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
90 100 110
....*....|....*....|....*....|
gi 2095916352 382 GALADTIGFSPLFAVLAVFDLLGALVIWTV 411
Cdd:COG0477 159 GLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-184 |
3.55e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.52 E-value: 3.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 2 RKIKGLRWYMIALVTLGTVLGYLTrntvAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKVGYAFF 81
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALT----VLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIG 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 82 AIAWAIFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMH 161
Cdd:cd06173 281 ALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
170 180
....*....|....*....|...
gi 2095916352 162 SWQMAFIISGVLSFAWAIAWLIF 184
Cdd:cd06173 361 GLSAVFLLAGALLLLAALLLLLL 383
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
63-189 |
4.54e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 39.23 E-value: 4.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 63 PVAGYVLDILGTKVGYAFFAIAWAIFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVG 142
Cdd:TIGR00898 145 FVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVF 224
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2095916352 143 SSIGAMIApPLVVWAIvmHSWQMAFIISGVLSFAWAIAWLIFYKHPR 189
Cdd:TIGR00898 225 FSLGLVLL-PLVAYFI--PDWRWLQLAVSLPTFLFFLLSWFVPESPR 268
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
237-416 |
4.85e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.95 E-value: 4.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 237 FLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLpplfqrwfgVNLIVSRKMVVTMGALLMIGP 316
Cdd:cd06174 6 FLTGLARGLISPLLPALL-QSFGLSASQLGLLFALFSLGYALLQPLAGLL---------ADRFGRRPVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 317 GMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALAD--TIGFSPLF 394
Cdd:cd06174 76 LLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVF 155
|
170 180
....*....|....*....|..
gi 2095916352 395 AVLAVFDLLGALVIWTVLKNKP 416
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPP 177
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
8-155 |
9.54e-03 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 38.15 E-value: 9.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095916352 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK----VGYAFFAI 83
Cdd:cd17334 2 RWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRigvlIGAALNAL 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2095916352 84 AWAIFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIG---AMIAPPLVV 155
Cdd:cd17334 82 GSVLKCIPLGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGcaiGFLLPPVVV 156
|
|
| |
