|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
8-416 |
0e+00 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 909.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87
Cdd:PRK07006 1 PAEGEKITVNNGKLNVPNNPIIPFIEGDGIGPDITPAMLKVVDAAVEKAYKGERKISWMEIYAGEKATKVYGEDVWLPEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKA 167
Cdd:PRK07006 81 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 168 DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQ 247
Cdd:PRK07006 161 GSAEAKKVIKFLQEEMGVKKIRFPETSGIGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 248 LAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327
Cdd:PRK07006 241 LAEEEFGDELIDGGPWDKIKNPETGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGAN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSE 407
Cdd:PRK07006 321 INDGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASKTVTYDFARLMEGATEVKCSE 400
|
....*....
gi 2095922621 408 FGDAIIKNM 416
Cdd:PRK07006 401 FGDALIKNM 409
|
|
| prok_nadp_idh |
TIGR00183 |
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent ... |
1-416 |
0e+00 |
|
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases. [Energy metabolism, TCA cycle]
Pssm-ID: 272948 Cd Length: 416 Bit Score: 834.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80
Cdd:TIGR00183 1 MYEKVKPPAQGEKITYENGKLNVPNNPIIPYIEGDGIGVDVTPAAIKVLDAAVEKAYKGEKKIVWFEVYAGEKAYQLYGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIY 160
Cdd:TIGR00183 81 DQWLPADTLDAIKEYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYKGVPSPVKHPEKVDMVIFRENTEDIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 161 AGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Cdd:TIGR00183 161 AGIEWAEGSEEAKKLIRFLQNELGVKKIRFPEDSGIGIKPISEEGTKRLVRAAIEYAIENDRKSVTLVHKGNIMKFTEGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320
Cdd:TIGR00183 241 FRDWGYELAKKEFGAECITWGLWDKYKNPNPGKEIVIKDRIADAFLQQILTRPDEYDVIATMNLNGDYISDALAAQVGGI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAINAKTVTYDFERLMDGA 400
Cdd:TIGR00183 321 GIAPGANIGDEIGIFEATHGTAPKYAGQDKVNPGSIILSGEMMLEHMGWKEAADLIKKAMEKAIASKIVTYDFARLMDGA 400
|
410
....*....|....*.
gi 2095922621 401 KLLKCSEFGDAIIKNM 416
Cdd:TIGR00183 401 KEVKCSEFAEAIIENM 416
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
10-416 |
0e+00 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 789.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 10 QGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQdvWLPAETL 89
Cdd:COG0538 2 EGEKIKVEDGKLKVPDNPIIPFIEGDGIGPEITRAIWKVIDAAVEKAYGGKRDIEWKEVDAGEKARDETGD--WLPDETA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 90 DLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADS 169
Cdd:COG0538 80 EAIKEYGVGIKGPLTTPVGGGWRSLNVTIRQILDLYVCRRPVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAGS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 170 ADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249
Cdd:COG0538 160 PEALKLIFFLEDEMGVTVIRFPEDSGIGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIG 329
Cdd:COG0538 240 EEEFGDKFITEGPWEKYKGPKPAGKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 330 DEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEF 408
Cdd:COG0538 320 DDGgAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKVTYDLARLMEGATELSTSEF 399
|
....*...
gi 2095922621 409 GDAIIKNM 416
Cdd:COG0538 400 GDAIIENL 407
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
28-412 |
1.33e-108 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 323.48 E-value: 1.33e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKgerKISWMEIYTGEKSTQVYGQdvWLPAETLDLIREYRVAIKGPLTTPV 107
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPL---EFEFEERDVGGAAIDETGE--PLPDETLEACKKADAVLLGAVGGPK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 108 G--GGIRSLN--VALRQELDLYICLRPVRYYQGT--PSPVK-HPELTDMVIFRENSEDIYAGIEWKADSADAEKvikflr 180
Cdd:pfam00180 76 WdpAGVRPENglLALRKELGLFANLRPAKVFPPLgdASPLKnEVEGVDIVIVRELTGGIYFGIEKGIKGSGNEV------ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 181 eemgvkkirfpehcGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGaFKDWGYQLAREEFGgelidg 260
Cdd:pfam00180 150 --------------AVDTKLYSRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSDL-WRKIVTEVAKAEYP------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 261 gpwlkvknpntgkEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATH 339
Cdd:pfam00180 209 -------------DVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGANGfGIFEPVH 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095922621 340 GTAPKYAGQDKVNPGSIILSAEMMLRH-MGWVEAADLIVKGMEGAINAKTVTYDferLMDGAKLLKCSEFGDAI 412
Cdd:pfam00180 276 GSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKVLESGIRTGD---LAGSATYVSTSEFGEAV 346
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
8-416 |
0e+00 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 909.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87
Cdd:PRK07006 1 PAEGEKITVNNGKLNVPNNPIIPFIEGDGIGPDITPAMLKVVDAAVEKAYKGERKISWMEIYAGEKATKVYGEDVWLPEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 88 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKA 167
Cdd:PRK07006 81 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 168 DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQ 247
Cdd:PRK07006 161 GSAEAKKVIKFLQEEMGVKKIRFPETSGIGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 248 LAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327
Cdd:PRK07006 241 LAEEEFGDELIDGGPWDKIKNPETGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGAN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSE 407
Cdd:PRK07006 321 INDGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASKTVTYDFARLMEGATEVKCSE 400
|
....*....
gi 2095922621 408 FGDAIIKNM 416
Cdd:PRK07006 401 FGDALIKNM 409
|
|
| prok_nadp_idh |
TIGR00183 |
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent ... |
1-416 |
0e+00 |
|
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases. [Energy metabolism, TCA cycle]
Pssm-ID: 272948 Cd Length: 416 Bit Score: 834.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80
Cdd:TIGR00183 1 MYEKVKPPAQGEKITYENGKLNVPNNPIIPYIEGDGIGVDVTPAAIKVLDAAVEKAYKGEKKIVWFEVYAGEKAYQLYGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIY 160
Cdd:TIGR00183 81 DQWLPADTLDAIKEYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYKGVPSPVKHPEKVDMVIFRENTEDIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 161 AGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Cdd:TIGR00183 161 AGIEWAEGSEEAKKLIRFLQNELGVKKIRFPEDSGIGIKPISEEGTKRLVRAAIEYAIENDRKSVTLVHKGNIMKFTEGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320
Cdd:TIGR00183 241 FRDWGYELAKKEFGAECITWGLWDKYKNPNPGKEIVIKDRIADAFLQQILTRPDEYDVIATMNLNGDYISDALAAQVGGI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAINAKTVTYDFERLMDGA 400
Cdd:TIGR00183 321 GIAPGANIGDEIGIFEATHGTAPKYAGQDKVNPGSIILSGEMMLEHMGWKEAADLIKKAMEKAIASKIVTYDFARLMDGA 400
|
410
....*....|....*.
gi 2095922621 401 KLLKCSEFGDAIIKNM 416
Cdd:TIGR00183 401 KEVKCSEFAEAIIENM 416
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
10-416 |
0e+00 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 789.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 10 QGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQdvWLPAETL 89
Cdd:COG0538 2 EGEKIKVEDGKLKVPDNPIIPFIEGDGIGPEITRAIWKVIDAAVEKAYGGKRDIEWKEVDAGEKARDETGD--WLPDETA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 90 DLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADS 169
Cdd:COG0538 80 EAIKEYGVGIKGPLTTPVGGGWRSLNVTIRQILDLYVCRRPVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAGS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 170 ADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249
Cdd:COG0538 160 PEALKLIFFLEDEMGVTVIRFPEDSGIGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIG 329
Cdd:COG0538 240 EEEFGDKFITEGPWEKYKGPKPAGKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 330 DEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEF 408
Cdd:COG0538 320 DDGgAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKVTYDLARLMEGATELSTSEF 399
|
....*...
gi 2095922621 409 GDAIIKNM 416
Cdd:COG0538 400 GDAIIENL 407
|
|
| PRK07362 |
PRK07362 |
NADP-dependent isocitrate dehydrogenase; |
1-415 |
0e+00 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 180944 Cd Length: 474 Bit Score: 557.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 1 MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80
Cdd:PRK07362 3 MYEKLTPPSTGSKITFKNGKPVVPDNPIIPFIRGDGTGVDIWPATQKVLDAAVAKAYGGERKINWFKVYAGDEACDLYGT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 81 DVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIY 160
Cdd:PRK07362 83 YQYLPEDTLEAIREYGVAIKGPLTTPIGGGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHKNPEKLDVIVYRENTEDIY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 161 AGIEWKADSADAEKVIKFLREEM-----GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA--IANDRDSVTLVHKGNI 233
Cdd:PRK07362 163 MGIEWEAGDEIGDKLIKHLNEEVipaspELGKRQIPLGSGIGIKPVSKTGSQRHIRRAIEHAlrLPGDKRHVTLVHKGNI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 234 MKFTEGAFKDWGYQLAREEFGGELI-DGGPWL---KVKNPNTGKE----------------------------------- 274
Cdd:PRK07362 243 MKYTEGAFRDWGYELATTEFRDECVtERESWIlsnKEKNPNISIEdnarmiepgydsltpekkaaicaevkevldsiwss 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 275 ---------IVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKY 345
Cdd:PRK07362 323 hgngkwkekVLVDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAPKH 402
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095922621 346 AGQDKVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAINAKTVTYDFERLMDGA-KLLKCSEFGDAIIKN 415
Cdd:PRK07362 403 AGLDRINPGSVILSGVMMLEYLGWQEAADLITKGLSAAIANKQVTYDLARLMEPPvDPLSCSEFAEAIISH 473
|
|
| PRK06451 |
PRK06451 |
NADP-dependent isocitrate dehydrogenase; |
7-416 |
8.50e-161 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803 Cd Length: 412 Bit Score: 458.91 E-value: 8.50e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 7 VPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDvwLPA 86
Cdd:PRK06451 4 IPEDGEVIKFENGKWIVPKKPIILYVEGDGIGPEITHAAMKVINKAVEKAYGSDREIKWVEVLAGDKAEKLTGNR--FPK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 87 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWK 166
Cdd:PRK06451 82 ESEELIEKYRVLLKGPLETPIGKGWKSINVAIRLMLDLYANIRPVKYIPGIESPLKNPEKIDLIIFRENTDDLYRGIEYP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 167 ADSADAEKVIKFLREEMGVKkirFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGY 246
Cdd:PRK06451 162 YDSEEAKKIRDFLRKELGVE---VEDDTGIGIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 247 QLAREEFGGELIDGGPWLKVKN--PNTGKeIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324
Cdd:PRK06451 239 EVALKEFRDYVVTEEEVTKNYNgvPPSGK-VIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAINAKTVTYDFERLMdGAKLLK 404
Cdd:PRK06451 318 GANIGDTGGMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKVTQDLARFM-GVRALS 396
|
410
....*....|..
gi 2095922621 405 CSEFGDAIIKNM 416
Cdd:PRK06451 397 TTEYTDELISII 408
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
28-412 |
1.33e-108 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 323.48 E-value: 1.33e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 28 IIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKgerKISWMEIYTGEKSTQVYGQdvWLPAETLDLIREYRVAIKGPLTTPV 107
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPL---EFEFEERDVGGAAIDETGE--PLPDETLEACKKADAVLLGAVGGPK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 108 G--GGIRSLN--VALRQELDLYICLRPVRYYQGT--PSPVK-HPELTDMVIFRENSEDIYAGIEWKADSADAEKvikflr 180
Cdd:pfam00180 76 WdpAGVRPENglLALRKELGLFANLRPAKVFPPLgdASPLKnEVEGVDIVIVRELTGGIYFGIEKGIKGSGNEV------ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 181 eemgvkkirfpehcGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGaFKDWGYQLAREEFGgelidg 260
Cdd:pfam00180 150 --------------AVDTKLYSRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSDL-WRKIVTEVAKAEYP------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 261 gpwlkvknpntgkEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATH 339
Cdd:pfam00180 209 -------------DVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGANGfGIFEPVH 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095922621 340 GTAPKYAGQDKVNPGSIILSAEMMLRH-MGWVEAADLIVKGMEGAINAKTVTYDferLMDGAKLLKCSEFGDAI 412
Cdd:pfam00180 276 GSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKVLESGIRTGD---LAGSATYVSTSEFGEAV 346
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
32-416 |
1.75e-104 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 312.72 E-value: 1.75e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 32 IEGDGIGVDVTPAMLKVVDAAvekAYKGERKISWMEIYTGEKSTQVYGQDvwLPAETLDLIREYRVAIKGPLTTPV---G 108
Cdd:COG0473 7 LPGDGIGPEVVAAALKVLEAA---AERFGLDFEFEEADIGGAAYDKTGTP--LPDETLEALRKADAILLGAVGGPKwddG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 109 GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVikflreemgvk 186
Cdd:COG0473 82 VRPESGLLALRKELDLYANLRPAKLYPGLPSPLKPeiVEGIDLVIVRENTEGLYFGIGGRIGTGTGEEV----------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 187 kirfpehcGIGIKPCSEEGTKRLVRAAIEYAIANdRDSVTLVHKGNIMKFTEGAFKDWGYQLAREefggelidggpwlkv 266
Cdd:COG0473 151 --------AIDTRVYTRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKE--------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 267 kNPntgkEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKY 345
Cdd:COG0473 207 -YP----DVELDHMYVDAAAMQLVRNPEQFDVIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEPVHGSAPDI 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095922621 346 AGQDKVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAINAKTVTYDFerlmdgAKLLKCSEFGDAIIKNM 416
Cdd:COG0473 282 AGKGIANPIATILSAAMMLRHLGEEEAADAIEAAVEKVLAEGVRTPDL------GGKAGTSEMGDAIIAAL 346
|
|
| PRK09222 |
PRK09222 |
NADP-dependent isocitrate dehydrogenase; |
32-416 |
7.96e-84 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236416 [Multi-domain] Cd Length: 482 Bit Score: 264.45 E-value: 7.96e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 32 IEGDGIGVDVTPAMLKVVDAAvekaykgERKISWMEIYTGEKstqVY--GQDVWLPAETLDLIREYRVAIKGPLTTPVGG 109
Cdd:PRK09222 10 AYGDGIGPEIMEAVLKILEAA-------GAPLEIETIEIGEK---VYkkGWTSGISPSAWESIRRTKVLLKAPITTPQGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 110 GIRSLNVALRQELDLYICLRPVRYYqgtpSPV---KHPELtDMVIFRENSEDIYAGIEWK--ADSADAEKVIkflreemg 184
Cdd:PRK09222 80 GYKSLNVTLRKTLGLYANVRPCVSY----HPFvetKHPNL-DVVIIRENEEDLYAGIEHRqtPDVYQCLKLI-------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 185 vkkirfpehcgigikpcSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEfggelidggpwl 264
Cdd:PRK09222 147 -----------------SRPGSEKIIRYAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEY------------ 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 265 kvknPNTGKEIVIKDvIADAflqQILLRPAEYDVIACMNLNGDYISDaLAAQV-GGIGIAPGANIGDECALFEATHGTAP 343
Cdd:PRK09222 198 ----PDIEAEHYIVD-IGAA---RLATNPENFDVIVTPNLYGDILSD-IAAEIsGSVGLAGSANIGEEYAMFEAVHGSAP 268
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2095922621 344 KYAGQDKVNPGSIILSAEMMLRHMGWVEAADLI----VKGMEGAINaktvTYDFERLMDGAKLLKCSEFGDAIIKNM 416
Cdd:PRK09222 269 DIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIenawLKTLEDGIH----TADIYNEGVSKKKVGTKEFAEAVIENL 341
|
|
| PRK08997 |
PRK08997 |
isocitrate dehydrogenase; Provisional |
29-413 |
9.33e-76 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 181606 Cd Length: 334 Bit Score: 238.85 E-value: 9.33e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 29 IPYIEGDGIGVDVTPAMLKVVDAA-----VEKAYKGERKIswmeiytgEKSTQVygqdvwLPAETLDLIREYRVAIKGPL 103
Cdd:PRK08997 5 ITVIPGDGIGPSIIDATLKILDKLgcdfeYEFADAGLTAL--------EKHGEL------LPQRTLDLIEKNKIALKGPL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 104 TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVkhpELTDMVIFRENSEDIYAGI--EWKADSADAEKVIKFLRE 181
Cdd:PRK08997 71 TTPVGEGFTSINVTLRKKFDLYANVRPVLSFPGTKARY---DNIDIITVRENTEGMYSGEgqTVSEDGETAEATSIITRK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 182 emgvkkirfpehcgigikpcseeGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDwgyqLAREefggelidgg 261
Cdd:PRK08997 148 -----------------------GAERIVRFAYELARKEGRKKVTAVHKANIMKSTSGLFLK----VARE---------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 262 pwLKVKNPntgkEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGT 341
Cdd:PRK08997 191 --VALRYP----DIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVGGLGMAPGANIGRDAAIFEAVHGS 264
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095922621 342 APKYAGQDKVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAINAKTVTydfERLMDGAKllKCSEFGDAII 413
Cdd:PRK08997 265 APDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRT---TRDLGGTH--GTTDFTQAVI 331
|
|
| mito_nad_idh |
TIGR00175 |
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ... |
32-416 |
1.02e-66 |
|
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]
Pssm-ID: 272942 Cd Length: 333 Bit Score: 215.71 E-value: 1.02e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 32 IEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEkstqvygqdvwLPAETLDLIREYRVAIKGPLTTPVG-GG 110
Cdd:TIGR00175 9 IPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTE-----------IPDEAVESIKRNKVALKGPLETPIGkGG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 111 IRSLNVALRQELDLYICLRPVRYYQGTPSPvkHPELtDMVIFRENSEDIYAGIEwkadsadAEKVikflreeMGVKKirf 190
Cdd:TIGR00175 78 HRSLNVALRKELDLYANVVHCKSLPGFKTR--HEDV-DIVIIRENTEGEYSGLE-------HESV-------PGVVE--- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 191 pehcgiGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEfggelidggpwlkvknpn 270
Cdd:TIGR00175 138 ------SLKVITRDKSERIARYAFEYARKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEY------------------ 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 271 tgKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFE-ATHGTAPKYAGQD 349
Cdd:TIGR00175 194 --PDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGGPGLVPGANIGRDYAVFEpGVRHTGPDIAGQN 271
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2095922621 350 KVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAI-NAKTVTYDFerlmdgAKLLKCSEFGDAIIKNM 416
Cdd:TIGR00175 272 IANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIaEGKNRTKDL------GGTATTSDFTEAVIKRL 333
|
|
| PRK14025 |
PRK14025 |
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional |
29-414 |
1.04e-61 |
|
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
Pssm-ID: 184462 Cd Length: 330 Bit Score: 202.29 E-value: 1.04e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 29 IPYIEGDGIGVDVTPAMLKVVdaaveKAYKGERKISWMEiyTGEKSTQVYGqdVWLPAETLDLIREYRVAIKGPLTTPVG 108
Cdd:PRK14025 4 ICVIEGDGIGKEVVPAALHVL-----EATGLPFEFVYAE--AGDEVFEKTG--KALPEETIEAAKEADAVLFGAAGETAA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 109 GGIrslnVALRQELDLYICLRPVRYYQGTPSpvKHPELtDMVIFRENSEDIYAGIEWKADS--ADAEKVIkflreemgvk 186
Cdd:PRK14025 75 DVI----VKLRRILDTYANVRPVKSYKGVKC--LYPDI-DYVIVRENTEGLYKGIEAEIADgvTVATRVI---------- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 187 kirfpehcgigikpcSEEGTKRLVRAAIEYA----IANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEfggelidggp 262
Cdd:PRK14025 138 ---------------TRKASERIFRFAFEMAkrrkKMGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEY---------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 263 wlkvknpntgKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTA 342
Cdd:PRK14025 193 ----------PDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDKYGLFEPVHGSA 262
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095922621 343 PKYAGQDKVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAINAKTVTYDFerlmdGAKlLKCSEFGDAIIK 414
Cdd:PRK14025 263 PDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGLTTPDL-----GGN-LSTMEMAEEVAK 328
|
|
| PLN00118 |
PLN00118 |
isocitrate dehydrogenase (NAD+) |
34-416 |
3.54e-56 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062 Cd Length: 372 Bit Score: 189.32 E-value: 3.54e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 34 GDGIGVDVTPAMLKVVDAAvekaykgERKISWMEIYTGEKSTQVYGQdvWLPAETLDLIREYRVAIKGPLTTPVGGGIRS 113
Cdd:PLN00118 49 GDGIGPEIAESVKQVFTAA-------GVPIEWEEHYVGTTVDPRTGS--FLTWESLESVRRNKVGLKGPMATPIGKGHRS 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 114 LNVALRQELDLYICLRPVRYYQGTPSPVKHpelTDMVIFRENSEDIYAGIEwkadsadaEKVIKFLREEmgvkkirfpeh 193
Cdd:PLN00118 120 LNLTLRKELGLYANVRPCYSLPGYKTRYDD---VDLVTIRENTEGEYSGLE--------HQVVRGVVES----------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 194 cgigIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFkdwgYQLAREefggelidggpwLKVKNPntgk 273
Cdd:PLN00118 178 ----LKIITRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLF----LKCCRE------------VAEKYP---- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 274 EIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE-CALFEATHGTAPKYAGQDKVN 352
Cdd:PLN00118 234 EIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENgLALAEAVHGSAPDIAGKNLAN 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2095922621 353 PGSIILSAEMMLRHMGWVEAADLIVKGMEGAI-NAKTVTYDFerlmdGAKlLKCSEFGDAIIKNM 416
Cdd:PLN00118 314 PTALLLSAVMMLRHLKLNEQAEQIHNAILNTIaEGKYRTADL-----GGS-STTTDFTKAICDHL 372
|
|
| PLN00123 |
PLN00123 |
isocitrate dehydrogenase (NAD+) |
32-416 |
1.13e-52 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215065 Cd Length: 360 Bit Score: 179.68 E-value: 1.13e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 32 IEGDGIGVDVTPAMLKVVDAAVEKAYkgerkiswMEIYtgekstQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGI 111
Cdd:PLN00123 36 IPGDGIGPLVTGAVEQVMEAMHAPVY--------FERY------EVHGDMKKVPEEVLESIRRNKVCLKGGLATPVGGGV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 112 RSLNVALRQELDLYICLrpVRYYQGTPSPVKHPELtDMVIFRENSEDIYAGIEwkadsadaEKVIKFLREEMGVKKirfp 191
Cdd:PLN00123 102 SSLNVQLRKELDLFASL--VNCFNLPGLPTRHENV-DIVVIRENTEGEYSGLE--------HEVVPGVVESLKVIT---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 192 ehcgigiKPCSEegtkRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAReefggelidggpwlkvKNPNt 271
Cdd:PLN00123 167 -------KFCSE----RIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAK----------------KYPG- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 272 gkeIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFE--ATHGTA--PKYAG 347
Cdd:PLN00123 219 ---IKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEqgASAGNVgnEKLVE 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 348 QDKVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAI-NAKTVTYDferlMDGAKLLKcsEFGDAIIKNM 416
Cdd:PLN00123 296 QKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIaEGKYRTKD----LGGSSTTQ--EVVDAVIANL 359
|
|
| PRK03437 |
PRK03437 |
3-isopropylmalate dehydrogenase; Provisional |
32-416 |
2.62e-52 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 179579 Cd Length: 344 Bit Score: 178.20 E-value: 2.62e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 32 IEGDGIGVDVTPAMLKVVDAAVEKAYK---------GERkisWMEiyTGEKstqvygqdvwLPAETLDLIREYRVAIKGP 102
Cdd:PRK03437 10 IPGDGIGPEVVAEALKVLDAVAAGGPGvetteydlgARR---YLR--TGET----------LPDSVLAELRQHDAILLGA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 103 LTTP-VGGGI--RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEwkadsadaekvikfl 179
Cdd:PRK03437 75 IGDPsVPSGVleRGLLLKLRFALDHYVNLRPSKLYPGVTSPLAGPGDIDFVVVREGTEGPYTGNG--------------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 180 reemGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFtegAFKDWgyQLAREEFGGELID 259
Cdd:PRK03437 140 ----GALRVGTPHEVATEVSVNTAFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTF---AGDLW--QRTVDEVAAEYPD 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 260 ggpwlkvknpntgkeiVIKDVI-ADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI---GDECALF 335
Cdd:PRK03437 211 ----------------VTVDYQhVDAATIFMVTDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNInptGTNPSMF 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 336 EATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWVEAADLIvkgmEGAINAKTVTydferlmDGAKLLKCSEFGDAIIKN 415
Cdd:PRK03437 275 EPVHGSAPDIAGQGIADPTAAILSVALLLDHLGEEDAAARI----EAAVEADLAE-------RGKMGRSTAEVGDRIAAR 343
|
.
gi 2095922621 416 M 416
Cdd:PRK03437 344 L 344
|
|
| PRK00772 |
PRK00772 |
3-isopropylmalate dehydrogenase; Provisional |
32-416 |
2.46e-45 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 234832 Cd Length: 358 Bit Score: 160.27 E-value: 2.46e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 32 IEGDGIGVDVTPAMLKVVDAAvekAYKGERKISWMEIYTGEKSTQVYGqdVWLPAETLDLIREYRV----AIKGPLTTPV 107
Cdd:PRK00772 8 LPGDGIGPEVMAEAVKVLDAV---AEKFGFDFEFEEALVGGAAIDAHG--VPLPEETLEACRAADAvllgAVGGPKWDNL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 108 GGGIRSLN--VALRQELDLYICLRPVRYYQG--TPSPVKhPEL---TDMVIFRENSEDIYAGiewkadsaDAEKVIKFLR 180
Cdd:PRK00772 83 PPDVRPERglLALRKELGLFANLRPAKLYPGlaDASPLK-PEIvagLDILIVRELTGGIYFG--------EPRGREGLGG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 181 EEMGVKKIRFpehcgigikpcSEEGTKRLVRAAIEyaIANDRDS-VTLVHKGNIMKftegafkdwgyqlareefGGELid 259
Cdd:PRK00772 154 EERAFDTMVY-----------TREEIERIARVAFE--LARKRRKkVTSVDKANVLE------------------SSRL-- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 260 ggpWlkvknpntgKEIVIK------DV-----IADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328
Cdd:PRK00772 201 ---W---------REVVTEvakeypDVelshmYVDNAAMQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 329 GDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWVEAADLIVKGMEGAINAKTVTYDferLMDGAKLLKCS 406
Cdd:PRK00772 269 GESGpGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEEAADAIEAAVEKVLAQGYRTAD---IAEGGGKVSTS 345
|
410
....*....|
gi 2095922621 407 EFGDAIIKNM 416
Cdd:PRK00772 346 EMGDAILAAL 355
|
|
| PRK08194 |
PRK08194 |
tartrate dehydrogenase; Provisional |
29-392 |
8.58e-39 |
|
tartrate dehydrogenase; Provisional
Pssm-ID: 181281 Cd Length: 352 Bit Score: 142.55 E-value: 8.58e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 29 IPYIEGDGIGVDVTPAMLKVVDAAVEkaYKGERKISWMEIYTGEKSTQVYGQdvWLPAETLDLIREYRV----AIKGPLT 104
Cdd:PRK08194 6 IAVIPGDGVGKEVVPAAVRVLKAVAE--VHGGLKFEFTEFPWSCEYYLEHGE--MMPEDGLEQLKQFDAiflgAVGNPKL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 105 TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAgiewkadsadaekvikflreEMG 184
Cdd:PRK08194 82 VPDHISLWGLLIKIRREFEQVINIRPAKQLRGIKSPLANPKDFDLLVVRENSEGEYS--------------------EVG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 185 VKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAiANDRDSVTLVHKGN----IMKFTEGAFKDWGyqlarEEFggelidg 260
Cdd:PRK08194 142 GRIHRGEDEIAIQNAVFTRKGTERAMRYAFELA-AKRRKHVTSATKSNgivhSMPFWDEVFQEVG-----KDY------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 261 gpwlkvknpntgKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI---GDECALFEA 337
Cdd:PRK08194 209 ------------PEIETDSQHIDALAAFFVTRPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANInvnGKYPSMFEP 276
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 2095922621 338 THGTAPKYAGQDKVNPGSIILSAEMMLRHMGWVEAADLIVKGMEGAINAKTVTYD 392
Cdd:PRK08194 277 VHGSAPDIAGKGIANPIGQIWTAKLMLDHFGEEELGSHLLDVIEDVTEDGIKTPD 331
|
|
| PLN02329 |
PLN02329 |
3-isopropylmalate dehydrogenase |
29-416 |
9.85e-18 |
|
3-isopropylmalate dehydrogenase
Pssm-ID: 215188 Cd Length: 409 Bit Score: 84.35 E-value: 9.85e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 29 IPYIEGDGIGvdvtPAMLKVVDAAVEKA-YKGERKISWMEIYTGEKSTQVYGqdVWLPAETLDLIREYRVAIKGPlttpV 107
Cdd:PLN02329 49 IALLPGDGIG----PEVISVAKNVLQKAgSLEGLEFDFQEMPVGGAALDLVG--VPLPEETFTAAKQSDAILLGA----I 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 108 GGGIRSLN----------VALRQELDLYICLRPV----RYYQGTPSPVKHPELTDMVIFRENSEDIYAGiewkadsadae 173
Cdd:PLN02329 119 GGYKWDKNekhlrpemalFYLRRDLKVFANLRPAtvlpQLVDASTLKKEVAEGVDMMIVRELTGGIYFG----------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 174 kvikflrEEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAiANDRDSVTLVHKGNIMKftegAFKDWGYQLAReef 253
Cdd:PLN02329 188 -------EPRGITINENGEEVGVSTEIYAAHEIDRIARVAFETA-RKRRGKLCSVDKANVLD----ASILWRKRVTA--- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 254 ggelidggpwLKVKNPntgkEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC- 332
Cdd:PLN02329 253 ----------LASEYP----DVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGp 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095922621 333 ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MGWVEAADLIVKGMEGAINAKTVTYDFerLMDGAKLLKCSEFGDA 411
Cdd:PLN02329 319 GLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKRIEDAVVDALNKGFRTGDI--YSPGNKLVGCKEMGEE 396
|
....*
gi 2095922621 412 IIKNM 416
Cdd:PLN02329 397 VLKSV 401
|
|
| |
