NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2102311721|gb|UBQ14207|]
View 

HAD family hydrolase (plasmid) [Enterococcus faecium]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HAD_2 super family cl37861
Haloacid dehalogenase-like hydrolase;
3-28 1.09e-04

Haloacid dehalogenase-like hydrolase;


The actual alignment was detected with superfamily member pfam13419:

Pssm-ID: 404323 [Multi-domain]  Cd Length: 178  Bit Score: 36.79  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*.
gi 2102311721   3 ITASDTKLHKPFPDPIQKAIDELGIK 28
Cdd:pfam13419 126 VGGDDVEGKKPDPDPILKALEQLGLK 151
 
Name Accession Description Interval E-value
HAD_2 pfam13419
Haloacid dehalogenase-like hydrolase;
3-28 1.09e-04

Haloacid dehalogenase-like hydrolase;


Pssm-ID: 404323 [Multi-domain]  Cd Length: 178  Bit Score: 36.79  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*.
gi 2102311721   3 ITASDTKLHKPFPDPIQKAIDELGIK 28
Cdd:pfam13419 126 VGGDDVEGKKPDPDPILKALEQLGLK 151
PRK13288 PRK13288
pyrophosphatase PpaX; Provisional
 3-28 2.56e-04

pyrophosphatase PpaX; Provisional


Pssm-ID: 237336 [Multi-domain]  Cd Length: 214  Bit Score: 35.78  E-value: 2.56e-04
                          10        20
                  ....*....|....*....|....*.
gi 2102311721   3 ITASDTKLHKPFPDPIQKAIDELGIK 28
Cdd:PRK13288  129 ITLDDVEHAKPDPEPVLKALELLGAK 154
Gph COG0546
Phosphoglycolate phosphatase, HAD superfamily [Energy production and conversion];
3-28 3.49e-03

Phosphoglycolate phosphatase, HAD superfamily [Energy production and conversion];


Pssm-ID: 440312 [Multi-domain]  Cd Length: 214  Bit Score: 32.59  E-value: 3.49e-03
                          10        20
                  ....*....|....*....|....*.
gi 2102311721   3 ITASDTKLHKPFPDPIQKAIDELGIK 28
Cdd:COG0546   131 VGGDDVPPAKPKPEPLLEALERLGLD 156
HAD_PPase cd02616
pyrophosphatase similar to Bacillus subtilis PpaX; This family includes Bacillus subtilis PpaX ...
 3-28 4.23e-03

pyrophosphatase similar to Bacillus subtilis PpaX; This family includes Bacillus subtilis PpaX which hydrolyzes pyrophosphate formed during serine-46-phosphorylated HPr (P-Ser-HPr) dephosphorylation by the bifunctional enzyme HPr kinase/phosphorylase. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319797 [Multi-domain]  Cd Length: 207  Bit Score: 32.25  E-value: 4.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 2102311721   3 ITASDTKLHKPFPDPIQKAIDELGIK 28
Cdd:cd02616   127 VGGDDVTHHKPDPEPVLKALELLGAE 152
 
Name Accession Description Interval E-value
HAD_2 pfam13419
Haloacid dehalogenase-like hydrolase;
3-28 1.09e-04

Haloacid dehalogenase-like hydrolase;


Pssm-ID: 404323 [Multi-domain]  Cd Length: 178  Bit Score: 36.79  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*.
gi 2102311721   3 ITASDTKLHKPFPDPIQKAIDELGIK 28
Cdd:pfam13419 126 VGGDDVEGKKPDPDPILKALEQLGLK 151
PRK13288 PRK13288
pyrophosphatase PpaX; Provisional
 3-28 2.56e-04

pyrophosphatase PpaX; Provisional


Pssm-ID: 237336 [Multi-domain]  Cd Length: 214  Bit Score: 35.78  E-value: 2.56e-04
                          10        20
                  ....*....|....*....|....*.
gi 2102311721   3 ITASDTKLHKPFPDPIQKAIDELGIK 28
Cdd:PRK13288  129 ITLDDVEHAKPDPEPVLKALELLGAK 154
Gph COG0546
Phosphoglycolate phosphatase, HAD superfamily [Energy production and conversion];
3-28 3.49e-03

Phosphoglycolate phosphatase, HAD superfamily [Energy production and conversion];


Pssm-ID: 440312 [Multi-domain]  Cd Length: 214  Bit Score: 32.59  E-value: 3.49e-03
                          10        20
                  ....*....|....*....|....*.
gi 2102311721   3 ITASDTKLHKPFPDPIQKAIDELGIK 28
Cdd:COG0546   131 VGGDDVPPAKPKPEPLLEALERLGLD 156
HAD_PPase cd02616
pyrophosphatase similar to Bacillus subtilis PpaX; This family includes Bacillus subtilis PpaX ...
 3-28 4.23e-03

pyrophosphatase similar to Bacillus subtilis PpaX; This family includes Bacillus subtilis PpaX which hydrolyzes pyrophosphate formed during serine-46-phosphorylated HPr (P-Ser-HPr) dephosphorylation by the bifunctional enzyme HPr kinase/phosphorylase. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319797 [Multi-domain]  Cd Length: 207  Bit Score: 32.25  E-value: 4.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 2102311721   3 ITASDTKLHKPFPDPIQKAIDELGIK 28
Cdd:cd02616   127 VGGDDVTHHKPDPEPVLKALELLGAE 152
YcjU COG0637
Beta-phosphoglucomutase, HAD superfamily [Carbohydrate transport and metabolism];
3-28 6.77e-03

Beta-phosphoglucomutase, HAD superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440402 [Multi-domain]  Cd Length: 208  Bit Score: 31.72  E-value: 6.77e-03
                          10        20
                  ....*....|....*....|....*.
gi 2102311721   3 ITASDTKLHKPFPDPIQKAIDELGIK 28
Cdd:COG0637   133 VTGDDVARGKPDPDIYLLAAERLGVD 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH