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Conserved domains on  [gi|2108213166|gb|UCF79897|]
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MAG: peptide chain release factor 1 [Candidatus Eisenbacteria bacterium]

Protein Classification

peptide chain release factor 1( domain architecture ID 11415460)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

Gene Ontology:  GO:0016149

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 1-345 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 637.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166   1 MFEEIQTIRARYEELTEKLADTAVLSDPQKLRDVAKERGALEPIVEKWKEYSSVAQNIAEDEQIIESSKDQELVGIARGE 80
Cdd:COG0216     2 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  81 LEELRERLDSLEEELRHLLVPKDPNDERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESKDWKIEIMNSSLTGVGGLKE 160
Cdd:COG0216    82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 161 IIFLIEGRGAFSHLRYESGVHRVQRVPVTEASGRIHTSAVTVAILPEAEEVEVEIDPKELEIDVFRSSGPGGQSVNTADS 240
Cdd:COG0216   162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 241 AVRIKHLPTGLVVQCQDERSQLKNKAKALKVLRARLLALKQEQQETEIAETRRAQVSSGDRSAKIRTYNFPQGRVTDHRI 320
Cdd:COG0216   242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                         330       340
                  ....*....|....*....|....*
gi 2108213166 321 GLTLYRLDTILEGGLDELVEALSAA 345
Cdd:COG0216   322 NLTLYKLDEVMEGDLDELIDALIAE 346
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 1-345 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 637.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166   1 MFEEIQTIRARYEELTEKLADTAVLSDPQKLRDVAKERGALEPIVEKWKEYSSVAQNIAEDEQIIESSKDQELVGIARGE 80
Cdd:COG0216     2 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  81 LEELRERLDSLEEELRHLLVPKDPNDERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESKDWKIEIMNSSLTGVGGLKE 160
Cdd:COG0216    82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 161 IIFLIEGRGAFSHLRYESGVHRVQRVPVTEASGRIHTSAVTVAILPEAEEVEVEIDPKELEIDVFRSSGPGGQSVNTADS 240
Cdd:COG0216   162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 241 AVRIKHLPTGLVVQCQDERSQLKNKAKALKVLRARLLALKQEQQETEIAETRRAQVSSGDRSAKIRTYNFPQGRVTDHRI 320
Cdd:COG0216   242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                         330       340
                  ....*....|....*....|....*
gi 2108213166 321 GLTLYRLDTILEGGLDELVEALSAA 345
Cdd:COG0216   322 NLTLYKLDEVMEGDLDELIDALIAE 346
prfA PRK00591
peptide chain release factor 1; Validated
 1-345 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 608.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166   1 MFEEIQTIRARYEELTEKLADTAVLSDPQKLRDVAKERGALEPIVEKWKEYSSVAQNIAEDEQIIESSKDQELVGIARGE 80
Cdd:PRK00591    4 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAKEE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  81 LEELRERLDSLEEELRHLLVPKDPNDERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESKDWKIEIMNSSLTGVGGLKE 160
Cdd:PRK00591   84 LKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 161 IIFLIEGRGAFSHLRYESGVHRVQRVPVTEASGRIHTSAVTVAILPEAEEVEVEIDPKELEIDVFRSSGPGGQSVNTADS 240
Cdd:PRK00591  164 VIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 241 AVRIKHLPTGLVVQCQDERSQLKNKAKALKVLRARLLALKQEQQETEIAETRRAQVSSGDRSAKIRTYNFPQGRVTDHRI 320
Cdd:PRK00591  244 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRI 323

                         330       340
                  ....*....|....*....|....*
gi 2108213166 321 GLTLYRLDTILEGGLDELVEALSAA 345
Cdd:PRK00591  324 NLTLYKLDEVMEGDLDELIDALIAE 348
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-345 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 507.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166   1 MFEEIQTIRARYEELTEKLADTAVLSDPQKLRDVAKERGALEPIVEKWKEYSSVAQNIAEDEQIIESSkDQELVGIARGE 80
Cdd:TIGR00019   5 LLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEES-DPEMREMAKEE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  81 LEELRERLDSLEEELRHLLVPKDPNDERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESKDWKIEIMNSSLTGVGGLKE 160
Cdd:TIGR00019  84 LEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGGYKE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 161 IIFLIEGRGAFSHLRYESGVHRVQRVPVTEASGRIHTSAVTVAILPEAEEVEVEIDPKELEIDVFRSSGPGGQSVNTADS 240
Cdd:TIGR00019 164 VIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 241 AVRIKHLPTGLVVQCQDERSQLKNKAKALKVLRARLLALKQEQQETEIAETRRAQVSSGDRSAKIRTYNFPQGRVTDHRI 320
Cdd:TIGR00019 244 AVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRI 323

                         330       340
                  ....*....|....*....|....*
gi 2108213166 321 GLTLYRLDTILEGGLDELVEALSAA 345
Cdd:TIGR00019 324 NLTLYKLDEVLEGDLDELIEALIAE 348
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 8-202 9.92e-101

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 295.06  E-value: 9.92e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166   8 IRARYEELTEKLADTAVLSDPQKLRDVAKERGALEPIVEKWKEYSSVAQNIAEDEQIIEsskDQELVGIARGELEELRER 87
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE---DPELAELAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  88 LDSLEEELRHLLVPKDPNDERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESKDWKIEIMNSSLTGVGGLKEIIFLIEG 167
Cdd:pfam03462  78 LEELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2108213166 168 RGAFSHLRYESGVHRVQRVPVTEASGRIHTSAVTV 202
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
63-177 3.01e-47

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 155.70  E-value: 3.01e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166   63 QIIESSKDQELVGIARGELEELRE-RLDSLEEELRHLLVPKDPNDERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESK 141
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEAeLEEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2108213166  142 DWKIEIMNSSLTGVGGLKEIIFLIEGRGAFSHLRYE 177
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 1-345 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 637.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166   1 MFEEIQTIRARYEELTEKLADTAVLSDPQKLRDVAKERGALEPIVEKWKEYSSVAQNIAEDEQIIESSKDQELVGIARGE 80
Cdd:COG0216     2 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  81 LEELRERLDSLEEELRHLLVPKDPNDERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESKDWKIEIMNSSLTGVGGLKE 160
Cdd:COG0216    82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 161 IIFLIEGRGAFSHLRYESGVHRVQRVPVTEASGRIHTSAVTVAILPEAEEVEVEIDPKELEIDVFRSSGPGGQSVNTADS 240
Cdd:COG0216   162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 241 AVRIKHLPTGLVVQCQDERSQLKNKAKALKVLRARLLALKQEQQETEIAETRRAQVSSGDRSAKIRTYNFPQGRVTDHRI 320
Cdd:COG0216   242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                         330       340
                  ....*....|....*....|....*
gi 2108213166 321 GLTLYRLDTILEGGLDELVEALSAA 345
Cdd:COG0216   322 NLTLYKLDEVMEGDLDELIDALIAE 346
prfA PRK00591
peptide chain release factor 1; Validated
 1-345 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 608.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166   1 MFEEIQTIRARYEELTEKLADTAVLSDPQKLRDVAKERGALEPIVEKWKEYSSVAQNIAEDEQIIESSKDQELVGIARGE 80
Cdd:PRK00591    4 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAKEE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  81 LEELRERLDSLEEELRHLLVPKDPNDERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESKDWKIEIMNSSLTGVGGLKE 160
Cdd:PRK00591   84 LKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 161 IIFLIEGRGAFSHLRYESGVHRVQRVPVTEASGRIHTSAVTVAILPEAEEVEVEIDPKELEIDVFRSSGPGGQSVNTADS 240
Cdd:PRK00591  164 VIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 241 AVRIKHLPTGLVVQCQDERSQLKNKAKALKVLRARLLALKQEQQETEIAETRRAQVSSGDRSAKIRTYNFPQGRVTDHRI 320
Cdd:PRK00591  244 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRI 323

                         330       340
                  ....*....|....*....|....*
gi 2108213166 321 GLTLYRLDTILEGGLDELVEALSAA 345
Cdd:PRK00591  324 NLTLYKLDEVMEGDLDELIDALIAE 348
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-345 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 507.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166   1 MFEEIQTIRARYEELTEKLADTAVLSDPQKLRDVAKERGALEPIVEKWKEYSSVAQNIAEDEQIIESSkDQELVGIARGE 80
Cdd:TIGR00019   5 LLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEES-DPEMREMAKEE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  81 LEELRERLDSLEEELRHLLVPKDPNDERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESKDWKIEIMNSSLTGVGGLKE 160
Cdd:TIGR00019  84 LEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGGYKE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 161 IIFLIEGRGAFSHLRYESGVHRVQRVPVTEASGRIHTSAVTVAILPEAEEVEVEIDPKELEIDVFRSSGPGGQSVNTADS 240
Cdd:TIGR00019 164 VIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 241 AVRIKHLPTGLVVQCQDERSQLKNKAKALKVLRARLLALKQEQQETEIAETRRAQVSSGDRSAKIRTYNFPQGRVTDHRI 320
Cdd:TIGR00019 244 AVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRI 323

                         330       340
                  ....*....|....*....|....*
gi 2108213166 321 GLTLYRLDTILEGGLDELVEALSAA 345
Cdd:TIGR00019 324 NLTLYKLDEVLEGDLDELIEALIAE 348
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 8-202 9.92e-101

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 295.06  E-value: 9.92e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166   8 IRARYEELTEKLADTAVLSDPQKLRDVAKERGALEPIVEKWKEYSSVAQNIAEDEQIIEsskDQELVGIARGELEELRER 87
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE---DPELAELAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  88 LDSLEEELRHLLVPKDPNDERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESKDWKIEIMNSSLTGVGGLKEIIFLIEG 167
Cdd:pfam03462  78 LEELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2108213166 168 RGAFSHLRYESGVHRVQRVPVTEASGRIHTSAVTV 202
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 8-341 1.12e-87

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 268.18  E-value: 1.12e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166   8 IRARYEELTEKLADTAVLSDPQKLRDVAKERGALEPIVEKWKEYSSVAQNIAEDEQIIESSKDQELVGIARGELEELRER 87
Cdd:TIGR00020  28 KKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSELLELAVEEDDEETFNELDAELKALEKK 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  88 LDSLEeeLRHLLvpKDPNDERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESKDWKIEIMNSSLTGVGGLKEIIFLIEG 167
Cdd:TIGR00020 108 LAELE--LRTML--SGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTILIKG 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 168 RGAFSHLRYESGVHRVQRVPVTEASGRIHTSAVTVAILPEA-EEVEVEIDPKELEIDVFRSSGPGGQSVNTADSAVRIKH 246
Cdd:TIGR00020 184 PYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVdDDIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAVRITH 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 247 LPTGLVVQCQDERSQLKNKAKALKVLRARLLALKQEQQETEIAETRRAQVSSGDRSaKIRTYNF-PQGRVTDHRIGLTLY 325
Cdd:TIGR00020 264 IPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGS-QIRSYVLhPYSMVKDLRTGYETG 342

                         330
                  ....*....|....*.
gi 2108213166 326 RLDTILEGGLDELVEA 341
Cdd:TIGR00020 343 NVQAVLDGDIDQFIEA 358
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 27-346 7.84e-62

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 200.73  E-value: 7.84e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  27 DPQKLRDVAKERGALEPIVEKWKEYSSVAQNIAEDEQIIESSKDQELVGIARGELEELRERLDslEEELRHLLvpKDPND 106
Cdd:PRK06746    9 DQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMN--EYELQLLL--SDPYD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 107 ERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESKDWKIEIMNSSLTGVGGLKEIIFLIEGRGAFSHLRYESGVHRVQRV 186
Cdd:PRK06746   85 KNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 187 PVTEASGRIHTSAVTVAILPE-AEEVEVEIDPKELEIDVFRSSGPGGQSVNTADSAVRIKHLPTGLVVQCQDERSQLKNK 265
Cdd:PRK06746  165 SPFDSSGRRHTSFVSCEVVPEfNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNR 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 266 AKALKVLRARLLALKQEQQETEIAETRRAQVSSGdRSAKIRTYNF-PQGRVTDHRIGLTLYRLDTILEGGLDELVEALSA 344
Cdd:PRK06746  245 EHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIG-WGSQIRSYVFhPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDAYLR 323


                  ..
gi 2108213166 345 AR 346
Cdd:PRK06746  324 SR 325
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 52-341 1.62e-61

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 199.50  E-value: 1.62e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  52 SSVAQNIAEDEQII---ESSKDQELVGIARGELEELRERLDSLEeeLRHLLVPKdpNDERNVIVEIRAGTGGEEAALFAS 128
Cdd:PRK08787   10 ADVLSGLADAGELLdlaESEQDEDTALAVIADLDKYQAHVEKLE--FQRMFSGQ--MDGANAFVDIQAGAGGTEAQDWAE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 129 DLSRMYMKYAESKDWKIEIMNSSLTGVGGLKEIIFLIEGRGAFSHLRYESGVHRVQRVPVTEASGRIHTSAVTVAILPEA 208
Cdd:PRK08787   86 ILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 209 EE-VEVEIDPKELEIDVFRSSGPGGQSVNTADSAVRIKHLPTGLVVQCQDERSQLKNKAKALKVLRARL--LALKQEQQE 285
Cdd:PRK08787  166 DDnIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLyeLEVQKRNAE 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2108213166 286 TEIAETRRAQVSSGdrsAKIRTYNFPQGRVTDHRIGLTLYRLDTILEGGLDELVEA 341
Cdd:PRK08787  246 KDALEATKSDIGWG---SQIRNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVEA 298
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 209-319 2.23e-61

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 191.87  E-value: 2.23e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 209 EEVEVEIDPKELEIDVFRSSGPGGQSVNTADSAVRIKHLPTGLVVQCQDERSQLKNKAKALKVLRARLLALKQEQQETEI 288
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKK 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2108213166 289 AETRRaQVSSGDRSAKIRTYNF-PQGRVTDHR 319
Cdd:pfam00472  81 RRIKS-QVGSGDRSEQIRTYNFkPQSRVKDHR 111
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 17-346 2.22e-59

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 194.71  E-value: 2.22e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  17 EKLADTAVLSDPQKLRDVAKERGALEPIVEKWKEYSSVAQNIAEDEQIIESSKDQELVGIARGELEELRERLDSLEEELR 96
Cdd:PRK07342    1 NKAEDPSLWNDAQEAQKLMRERQQLDDSINGINHLEQTLNDNIELIAMGEEEGDKSIVEDAEKTIRDLKDEIDRRQIDAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  97 hLLVPKDPNDernVIVEIRAGTGGEEAALFASDLSRMYMKYAESKDWKIEIMNSSLTGVGGLKEIIFLIEGRGAFSHLRY 176
Cdd:PRK07342   81 -LSGEADAND---TYLEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 177 ESGVHRVQRVPVTEASGRIHTSAVTVAILPEAEE-VEVEIDPKELEIDVFRSSGPGGQSVNTADSAVRIKHLPTGLVVQC 255
Cdd:PRK07342  157 ESGVHRLVRISPYDSNARRHTSFASIWVYPVIDDnIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQC 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 256 QDERSQLKNKAKALKVLRARL--LALKQEQQETEIAETRRAQVSSGDrsaKIRTYNF-PQGRVTDHRIGLTLYRLDTILE 332
Cdd:PRK07342  237 QQERSQHKNRAKAWSMLRARLyeEELKKREEATNAAAASKTDIGWGH---QIRSYVLqPYQLVKDLRTGVESTNPQDVLD 313

                         330
                  ....*....|....
gi 2108213166 333 GGLDELVEALSAAR 346
Cdd:PRK07342  314 GDLNEFMEAALAHR 327
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 27-341 1.75e-54

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 181.54  E-value: 1.75e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166  27 DPQKLRDVAKERGALEpivEKWKEYSSVAQNIAEDEQIIESSK--DQELVGIARGELEELRERLDSLEEELrhLLVPKdp 104
Cdd:PRK05589    9 DIKEAQEITSEEKYLK---DKLDKYNHLRNRIEDIEVLCEMMSeeDDEMKKEIISEVKNIKEEIDRFKIET--LLSGE-- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 105 NDERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESKDWKIEIMNSSLTGVGGLKEIIFLIEGRGAFSHLRYESGVHRVQ 184
Cdd:PRK05589   82 YDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 185 RVPVTEASGRIHTSAVTVAILPE-AEEVEVEIDPKELEIDVFRSSGPGGQSVNTADSAVRIKHLPTGLVVQCQDERSQLK 263
Cdd:PRK05589  162 RISPFNANGKRQTSFASVEVLPElTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHS 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2108213166 264 NKAKALKVLRARLLALKqEQQETEIAETRRAQVSSGDRSAKIRTYNF-PQGRVTDHRIGLTLYRLDTILEGGLDELVEA 341
Cdd:PRK05589  242 NKETAMKMLKSKLVELK-ERAHKEKIEDLTGELKDMGWGSQIRSYVFhPYNLVKDHRTGVETSNVDSVMDGDIDNFITQ 319
PCRF smart00937
This domain is found in peptide chain release factors;
63-177 3.01e-47

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 155.70  E-value: 3.01e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166   63 QIIESSKDQELVGIARGELEELRE-RLDSLEEELRHLLVPKDPNDERNVIVEIRAGTGGEEAALFASDLSRMYMKYAESK 141
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEAeLEEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2108213166  142 DWKIEIMNSSLTGVGGLKEIIFLIEGRGAFSHLRYE 177
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 212-319 1.97e-34

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 123.32  E-value: 1.97e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 212 EVEIDPKELEIDVFRSSGPGGQSVNTADSAVRIKH------------LPTGLVVQCQDERSQLKNKAKALKVLRARLL-A 278
Cdd:COG1186    20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYeA 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2108213166 279 LKQEQQETEIAETRRAQVSSGDRSaKIRtynfpqGRVTDHR 319
Cdd:COG1186   100 ELEPKERRATKPTRGSKKRRLWGK-QIR------SMVKDLR 133
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 214-300 7.99e-19

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 83.28  E-value: 7.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 214 EIDPKELEIDVFRSSGPGGQSVNTADSAVRIKHLPTGLVVQCQDERSQLKNKAKALKVLRARLLALKQEQQETEIAETRR 293
Cdd:TIGR03072 102 EATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVRLADLQQEQAAALRAERRT 181


                  ....*....
gi 2108213166 294 A--QVSSGD 300
Cdd:TIGR03072 182 AhhQIERGN 190
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
213-279 6.97e-10

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 56.70  E-value: 6.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108213166 213 VEIDPKELEIDVFRSSGPGGQSVNTADSAVRIK------HLP---------------TG---LVVQCQDERSQLKNKAKA 268
Cdd:PRK09256    8 LVIPENELEWRFIRASGPGGQNVNKVSTAVELRfdiaasSLPefykerllalaghriTKdgvIVIKAQEFRSQERNREDA 87

                          90
                  ....*....|.
gi 2108213166 269 lkvlRARLLAL 279
Cdd:PRK09256   88 ----LERLVAL 94
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
29-98 1.08e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.05  E-value: 1.08e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2108213166   29 QKLRDVAKERGALEPIVEKWKEYSSVAQNIAEDEQIIESS---KDQELVGIARGELEELRERLDSLEEELRHL 98
Cdd:COG4913    242 EALEDAREQIELLEPIRELAERYAAARERLAELEYLRAALrlwFAQRRLELLEAELEELRAELARLEAELERL 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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