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Conserved domains on  [gi|2108273383|gb|UCG39803|]
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ubiquinone/menaquinone biosynthesis methyltransferase [bacterium]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 1-223 4.29e-91

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member PRK00216:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 239  Bit Score: 267.79  E-value: 4.29e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383   1 MFSAIAGRYDLLNRLFSLGTDVRWRRELASEI-PREGRLpVLDVATGTGDVPLALRASFPEDRRILGLDFTLPMLRIAAG 79
Cdd:PRK00216   16 MFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLgVRPGDK-VLDLACGTGDLAIALAKAVGKTGEVVGLDFSEGMLAVGRE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  80 KLAGKGARS-VSLAAGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVVLEFSPVQRPLIGPLFRFY 158
Cdd:PRK00216   95 KLRDLGLSGnVEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGRLVILEFSKPTNPPLKKAYDFY 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2108273383 159 FHRIMPFAGGIISGDAAAYSYLPRSVDAFPDPGLLVREMLEAGLSNVRCRSLTFGIAYLHVGEKE 223
Cdd:PRK00216  175 LFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRYRNLTGGIVALHVGYKP 239
 
Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 1-223 4.29e-91

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 267.79  E-value: 4.29e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383   1 MFSAIAGRYDLLNRLFSLGTDVRWRRELASEI-PREGRLpVLDVATGTGDVPLALRASFPEDRRILGLDFTLPMLRIAAG 79
Cdd:PRK00216   16 MFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLgVRPGDK-VLDLACGTGDLAIALAKAVGKTGEVVGLDFSEGMLAVGRE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  80 KLAGKGARS-VSLAAGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVVLEFSPVQRPLIGPLFRFY 158
Cdd:PRK00216   95 KLRDLGLSGnVEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGRLVILEFSKPTNPPLKKAYDFY 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2108273383 159 FHRIMPFAGGIISGDAAAYSYLPRSVDAFPDPGLLVREMLEAGLSNVRCRSLTFGIAYLHVGEKE 223
Cdd:PRK00216  175 LFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRYRNLTGGIVALHVGYKP 239
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 1-222 4.81e-87

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 257.19  E-value: 4.81e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383   1 MFSAIAGRYDLLNRLFSLGTDVRWRRELASEIPREGRLPVLDVATGTGDVPLALRASFPEDRRILGLDFTLPMLRIAAGK 80
Cdd:TIGR01934   4 MFDRIAPKYDLLNDLLSFGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIELAKSAPDRGKVTGVDFSSEMLEVAKKK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  81 LAGKGarSVSLAAGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVVLEFSPVQRPLIGPLFRFYFH 160
Cdd:TIGR01934  84 SELPL--NIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEFSKPANALLKKFYKFYLK 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2108273383 161 RIMPFAGGIISGDAAAYSYLPRSVDAFPDPGLLVREMLEAGLSNVRCRSLTFGIAYLHVGEK 222
Cdd:TIGR01934 162 NVLPSIGGLISKNAEAYTYLPESIRAFPSQEELAAMLKEAGFEEVRYRSLTFGVAAIHVGKK 223
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
2-222 2.70e-59

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 186.88  E-value: 2.70e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383   2 FSAIAGRYDLLNRLFSLGTDVRWRRELASEI-PREGrLPVLDVATGTGDVPLALRASFPEDRRILGLDFTLPMLRIAAGK 80
Cdd:pfam01209   8 FSSVASKYDLMNDVISFGIHRLWKDFTMKCMgVKRG-NKFLDVAGGTGDWTFGLSDSAGSSGKVVGLDINENMLKEGEKK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  81 LAGKGARSVSLAAGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVVLEFSPVQRPLIGPLFRFYFH 160
Cdd:pfam01209  87 AKEEGKYNIEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVVCLEFSKPENPLLSQAYELYFK 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2108273383 161 RIMPFAGGIISGDAAAYSYLPRSVDAFPDPGLLVREMLEAGLSNVRCRSLTFGIAYLHVGEK 222
Cdd:pfam01209 167 YVMPFMGKMFAKSYKSYQYLQESIRDFPDQKTLASMFEKAGFKSVGYESLTGGIAAIHWGIK 228
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 2-156 2.24e-31

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 112.39  E-value: 2.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383   2 FSAIAGRYDLlnrlfslgtdvrwRRELASEIPREGRLPVLDVATGTGDVPLALRAsfpEDRRILGLDFTLPMLRIAAGKL 81
Cdd:COG2226     1 FDRVAARYDG-------------REALLAALGLRPGARVLDLGCGTGRLALALAE---RGARVTGVDISPEMLELARERA 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2108273383  82 AGKGARsVSLAAGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVVLEFSPVQRPLIGPLFR 156
Cdd:COG2226    65 AEAGLN-VEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLA 138
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 40-140 5.84e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.43  E-value: 5.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  40 VLDVATGTGDVPLALRASfpEDRRILGLDFTLPMLRIAAGKLAGKGARSVSLAAGDAFALP-VRDGAFDAV-TIAFGLRN 117
Cdd:cd02440     2 VLDLGCGTGALALALASG--PGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPpEADESFDVIiSDPPLHHL 79

                          90       100
                  ....*....|....*....|...
gi 2108273383 118 LSDRVAALREMVRALRPGGRVVV 140
Cdd:cd02440    80 VEDLARFLEEARRLLKPGGVLVL 102
 
Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 1-223 4.29e-91

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 267.79  E-value: 4.29e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383   1 MFSAIAGRYDLLNRLFSLGTDVRWRRELASEI-PREGRLpVLDVATGTGDVPLALRASFPEDRRILGLDFTLPMLRIAAG 79
Cdd:PRK00216   16 MFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLgVRPGDK-VLDLACGTGDLAIALAKAVGKTGEVVGLDFSEGMLAVGRE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  80 KLAGKGARS-VSLAAGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVVLEFSPVQRPLIGPLFRFY 158
Cdd:PRK00216   95 KLRDLGLSGnVEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGRLVILEFSKPTNPPLKKAYDFY 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2108273383 159 FHRIMPFAGGIISGDAAAYSYLPRSVDAFPDPGLLVREMLEAGLSNVRCRSLTFGIAYLHVGEKE 223
Cdd:PRK00216  175 LFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRYRNLTGGIVALHVGYKP 239
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 1-222 4.81e-87

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 257.19  E-value: 4.81e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383   1 MFSAIAGRYDLLNRLFSLGTDVRWRRELASEIPREGRLPVLDVATGTGDVPLALRASFPEDRRILGLDFTLPMLRIAAGK 80
Cdd:TIGR01934   4 MFDRIAPKYDLLNDLLSFGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIELAKSAPDRGKVTGVDFSSEMLEVAKKK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  81 LAGKGarSVSLAAGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVVLEFSPVQRPLIGPLFRFYFH 160
Cdd:TIGR01934  84 SELPL--NIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEFSKPANALLKKFYKFYLK 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2108273383 161 RIMPFAGGIISGDAAAYSYLPRSVDAFPDPGLLVREMLEAGLSNVRCRSLTFGIAYLHVGEK 222
Cdd:TIGR01934 162 NVLPSIGGLISKNAEAYTYLPESIRAFPSQEELAAMLKEAGFEEVRYRSLTFGVAAIHVGKK 223
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
2-222 2.70e-59

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 186.88  E-value: 2.70e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383   2 FSAIAGRYDLLNRLFSLGTDVRWRRELASEI-PREGrLPVLDVATGTGDVPLALRASFPEDRRILGLDFTLPMLRIAAGK 80
Cdd:pfam01209   8 FSSVASKYDLMNDVISFGIHRLWKDFTMKCMgVKRG-NKFLDVAGGTGDWTFGLSDSAGSSGKVVGLDINENMLKEGEKK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  81 LAGKGARSVSLAAGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVVLEFSPVQRPLIGPLFRFYFH 160
Cdd:pfam01209  87 AKEEGKYNIEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVVCLEFSKPENPLLSQAYELYFK 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2108273383 161 RIMPFAGGIISGDAAAYSYLPRSVDAFPDPGLLVREMLEAGLSNVRCRSLTFGIAYLHVGEK 222
Cdd:pfam01209 167 YVMPFMGKMFAKSYKSYQYLQESIRDFPDQKTLASMFEKAGFKSVGYESLTGGIAAIHWGIK 228
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 2-156 2.24e-31

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 112.39  E-value: 2.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383   2 FSAIAGRYDLlnrlfslgtdvrwRRELASEIPREGRLPVLDVATGTGDVPLALRAsfpEDRRILGLDFTLPMLRIAAGKL 81
Cdd:COG2226     1 FDRVAARYDG-------------REALLAALGLRPGARVLDLGCGTGRLALALAE---RGARVTGVDISPEMLELARERA 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2108273383  82 AGKGARsVSLAAGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVVLEFSPVQRPLIGPLFR 156
Cdd:COG2226    65 AEAGLN-VEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLA 138
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 1-214 1.37e-29

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 111.14  E-value: 1.37e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383   1 MFSAIAGRYDLLNRLFSLGTDVRWRRELASEIPREGRLPVLDVATGTGDVPLALRASFPEDRRILGLDFTLPMLRIAAGK 80
Cdd:PLN02233   38 LFNRIAPVYDNLNDLLSLGQHRIWKRMAVSWSGAKMGDRVLDLCCGSGDLAFLLSEKVGSDGKVMGLDFSSEQLAVAASR 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  81 ---LAGKGARSVSLAAGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVVLEFSPVQRPLIGPLFRF 157
Cdd:PLN02233  118 qelKAKSCYKNIEWIEGDATDLPFDDCYFDAITMGYGLRNVVDRLKAMQEMYRVLKPGSRVSILDFNKSTQPFTTSMQEW 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2108273383 158 YFHR-IMPFAGGIisGDAAAYSYLPRSVDAFPDPGLLVREMLEAGLSNVRCRSLTFGI 214
Cdd:PLN02233  198 MIDNvVVPVATGY--GLAKEYEYLKSSINEYLTGEELEKLALEAGFSSAKHYEISGGL 253
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 40-136 2.02e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 84.92  E-value: 2.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  40 VLDVATGTGDVPLALRASFpeDRRILGLDFTLPMLRIAAGKLAGKGARsVSLAAGDAFALPVRDGAFDAVTIAFGLRNLS 119
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG--GARVTGVDLSPEMLERARERAAEAGLN-VEFVQGDAEDLPFPDGSFDLVVSSGVLHHLP 77

                          90
                  ....*....|....*....
gi 2108273383 120 --DRVAALREMVRALRPGG 136
Cdd:pfam13649  78 dpDLEAALREIARVLKPGG 96
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 65-204 1.02e-17

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 77.42  E-value: 1.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  65 LGLDFTLPMLRIAAGKLAGKgARS----VSLAAGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVV 140
Cdd:PLN02232    1 MGLDFSSEQLAVAATRQSLK-ARScykcIEWIEGDAIDLPFDDCEFDAVTMGYGLRNVVDRLRAMKEMYRVLKPGSRVSI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2108273383 141 LEFSPVQRPLIGPLFRFYFHR-IMPFAggIISGDAAAYSYLPRSVDAFPDPGLLVREMLEAGLSN 204
Cdd:PLN02232   80 LDFNKSNQSVTTFMQGWMIDNvVVPVA--TVYDLAKEYEYLKYSINGYLTGEELETLALEAGFSS 142
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 41-140 1.05e-17

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 75.39  E-value: 1.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  41 LDVATGTGDVPLALRASFPedrRILGLDFTLPMLRIAAGKLAGKGarsVSLAAGDAFALPVRDGAFDAVTIAFGLRNLSD 120
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA---RVTGVDISPEMLELAREKAPREG---LTFVVGDAEDLPFPDNSFDLVLSSEVLHHVED 74

                          90       100
                  ....*....|....*....|
gi 2108273383 121 RVAALREMVRALRPGGRVVV 140
Cdd:pfam08241  75 PERALREIARVLKPGGILII 94
PRK08317 PRK08317
hypothetical protein; Provisional
 40-143 7.30e-17

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 76.90  E-value: 7.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  40 VLDVATGTGDVPLALRASFPEDRRILGLDFTLPMLRIAAGKLAGkGARSVSLAAGDAFALPVRDGAFDAVTIAFGLRNLS 119
Cdd:PRK08317   23 VLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKERAAG-LGPNVEFVRGDADGLPFPDGSFDAVRSDRVLQHLE 101

                          90       100
                  ....*....|....*....|....
gi 2108273383 120 DRVAALREMVRALRPGGRVVVLEF 143
Cdd:PRK08317  102 DPARALAEIARVLRPGGRVVVLDT 125
PRK05785 PRK05785
hypothetical protein; Provisional
 5-222 1.47e-16

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 75.88  E-value: 1.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383   5 IAGRYDLLNRLFSLGTDVRWRRELASEI----PREGRlpVLDVATGTGDVPLALRASFpeDRRILGLDFTLPMLRIAagk 80
Cdd:PRK05785   18 IPKAYDRANRFISFNQDVRWRAELVKTIlkycGRPKK--VLDVAAGKGELSYHFKKVF--KYYVVALDYAENMLKMN--- 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  81 lAGKGARSVslaaGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVVL--EFSPVQRPLIGplfrFY 158
Cdd:PRK05785   91 -LVADDKVV----GSFEALPFRDKSFDVVMSSFALHASDNIEKVIAEFTRVSRKQVGFIAMgkPDNVIKRKYLS----FY 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2108273383 159 FHRIMPFAGGIISGDAAAYSYLPRSVDAFPdPGLLVREMLEAGLSNVRCRSLTFGIAYLHVGEK 222
Cdd:PRK05785  162 LRYIMPYIACLAGAKCRDYKYIYYIYERLP-TNSFHREIFEKYADIKVYEERGLGLVYFVVGSS 224
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 23-140 3.12e-14

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 66.96  E-value: 3.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  23 RWRRELASEIPREGRLP--VLDVATGTGDVPLALRAsfpEDRRILGLDFTLPMLRIAAGKLAgkgARSVSLAAGDAFALP 100
Cdd:COG2227     9 FWDRRLAALLARLLPAGgrVLDVGCGTGRLALALAR---RGADVTGVDISPEALEIARERAA---ELNVDFVQGDLEDLP 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2108273383 101 VRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVV 140
Cdd:COG2227    83 LEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLL 122
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
40-140 2.23e-13

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 64.07  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  40 VLDVATGTGDVPLALRASFPeDRRILGLDFTLPMLRIAAGKLAGkgarsVSLAAGDAFALPVrDGAFDAVTIAFGLRNLS 119
Cdd:COG4106     5 VLDLGCGTGRLTALLAERFP-GARVTGVDLSPEMLARARARLPN-----VRFVVADLRDLDP-PEPFDLVVSNAALHWLP 77

                          90       100
                  ....*....|....*....|.
gi 2108273383 120 DRVAALREMVRALRPGGRVVV 140
Cdd:COG4106    78 DHAALLARLAAALAPGGVLAV 98
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
1-139 5.59e-13

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 65.02  E-value: 5.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383   1 MFSAIAGRYD--LLNRLFSLGTDvRWRRELASEIPREGRLPVLDVATGTGDVPLALRASFpedRRILGLDFTLPMLRIAA 78
Cdd:COG4976    10 LFDQYADSYDaaLVEDLGYEAPA-LLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRG---YRLTGVDLSEEMLAKAR 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2108273383  79 GKLAGkgarsVSLAAGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVV 139
Cdd:COG4976    86 EKGVY-----DRLLVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFI 141
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 38-147 7.79e-13

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 63.98  E-value: 7.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  38 LPVLDVATGTGDVPLALRASFPEDRRILGLDFTLPMLRIAAGKLAGKGARSVSLAAGDAFALP--VRDGAFDaVTIAFGL 115
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPelLEDDKFD-VVISNCV 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2108273383 116 RNLS-DRVAALREMVRALRPGGRVVVLEFSPVQ 147
Cdd:pfam13847  84 LNHIpDPDKVLQEILRVLKPGGRLIISDPDSLA 116
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 41-138 7.01e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 60.07  E-value: 7.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  41 LDVATGTGDVPLALRASFPeDRRILGLDFTLPMLRIAAGKLAGKGARSVSLAAGDAFALPVRDG-AFDAVTIAFGLRNLS 119
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALP-GLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPgSFDVVVASNVLHHLA 79

                          90
                  ....*....|....*....
gi 2108273383 120 DRVAALREMVRALRPGGRV 138
Cdd:pfam08242  80 DPRAVLRNIRRLLKPGGVL 98
arsM PRK11873
arsenite methyltransferase;
40-140 1.33e-11

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 62.66  E-value: 1.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  40 VLDVATGTG-DVPLALRASFPEDRRIlGLDFTLPMLRIAAGKLAGKGARSVSLAAGDAFALPVRDGAFDaVTIAFGLRNL 118
Cdd:PRK11873   81 VLDLGSGGGfDCFLAARRVGPTGKVI-GVDMTPEMLAKARANARKAGYTNVEFRLGEIEALPVADNSVD-VIISNCVINL 158

                          90       100
                  ....*....|....*....|...
gi 2108273383 119 S-DRVAALREMVRALRPGGRVVV 140
Cdd:PRK11873  159 SpDKERVFKEAFRVLKPGGRFAI 181
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 40-144 4.57e-11

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 60.76  E-value: 4.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  40 VLDVATGTGDVPLALRASFPEDrRILGLDFTLPMLRIAAGKLAGKgarsVSLAAGDAFALPVRDGAFDAVTIAFGLRNLS 119
Cdd:TIGR02072  38 VLDIGCGTGYLTRALLKRFPQA-EFIALDISAGMLAQAKTKLSEN----VQFICGDAEKLPLEDSSFDLIVSNLALQWCD 112

                          90       100
                  ....*....|....*....|....*
gi 2108273383 120 DRVAALREMVRALRPGGrvvVLEFS 144
Cdd:TIGR02072 113 DLSQALSELARVLKPGG---LLAFS 134
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 19-140 3.15e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 57.62  E-value: 3.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  19 GTDVRWRRELASEIPREGRLP----VLDVATGTGDVPLALRASFpeDRRILGLDFTLPMLRIAAGKLAGKGARSVSLAAG 94
Cdd:COG0500     5 YYSDELLPGLAALLALLERLPkggrVLDLGCGTGRNLLALAARF--GGRVIGIDLSPEAIALARARAAKAGLGNVEFLVA 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2108273383  95 DAFAL-PVRDGAFDAVtIAFGL---RNLSDRVAALREMVRALRPGGRVVV 140
Cdd:COG0500    83 DLAELdPLPAESFDLV-VAFGVlhhLPPEEREALLRELARALKPGGVLLL 131
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 40-140 5.84e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.43  E-value: 5.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  40 VLDVATGTGDVPLALRASfpEDRRILGLDFTLPMLRIAAGKLAGKGARSVSLAAGDAFALP-VRDGAFDAV-TIAFGLRN 117
Cdd:cd02440     2 VLDLGCGTGALALALASG--PGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPpEADESFDVIiSDPPLHHL 79

                          90       100
                  ....*....|....*....|...
gi 2108273383 118 LSDRVAALREMVRALRPGGRVVV 140
Cdd:cd02440    80 VEDLARFLEEARRLLKPGGVLVL 102
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 34-141 1.41e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 49.95  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  34 REGRLpVLDVATGTGDVPL-ALRASfpedRRILGLDFTLPMLRIAAGKLAGKGARSVSLAAGDAFALPVRDGAFDAV--- 109
Cdd:COG1041    25 KEGDT-VLDPFCGTGTILIeAGLLG----RRVIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDLPLADESVDAIvtd 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2108273383 110 --------TIAFGLRNLSDRvaALREMVRALRPGGRVVVL 141
Cdd:COG1041   100 ppygrsskISGEELLELYEK--ALEEAARVLKPGGRVVIV 137
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 28-138 1.05e-05

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 45.13  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  28 LASEIPREGRLPVLDVATGTGDVPLALRASFPEdrrILGLDFTLPMLRIAAGKLAGKgarsvSLAAGDAFALPVRDGAFD 107
Cdd:PRK10258   34 LLAMLPQRKFTHVLDAGCGPGWMSRYWRERGSQ---VTALDLSPPMLAQARQKDAAD-----HYLAGDIESLPLATATFD 105

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2108273383 108 AVTIAFGLRNLSDRVAALREMVRALRPGGRV 138
Cdd:PRK10258  106 LAWSNLAVQWCGNLSTALRELYRVVRPGGVV 136
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 9-140 1.78e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 43.76  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383   9 YDLLNRLFSLGTDVRWR-----------------RELASEIPREGRLP----VLDVATGTGDvpLALRASFPEDRRILGL 67
Cdd:COG2230     3 YDLGNDFYRLFLDPTMTyscayfedpddtleeaqEAKLDLILRKLGLKpgmrVLDIGCGWGG--LALYLARRYGVRVTGV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2108273383  68 DFTLPMLRIAAGKLAGKG-ARSVSLAAGDAFALPvRDGAFDAV-----TIAFGLRNLSdrvAALREMVRALRPGGRVVV 140
Cdd:COG2230    81 TLSPEQLEYARERAAEAGlADRVEVRLADYRDLP-ADGQFDAIvsigmFEHVGPENYP---AYFAKVARLLKPGGRLLL 155
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 23-143 7.43e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 42.03  E-value: 7.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  23 RWRRELASEIPREGRlpVLDVATGTGDVPLALRASFPEdrrILGLDFTLPMLRIAAGKLAGKGARSVSLAagdafalpVR 102
Cdd:pfam13489  11 DLLLRLLPKLPSPGR--VLDFGCGTGIFLRLLRAQGFS---VTGVDPSPIAIERALLNVRFDQFDEQEAA--------VP 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2108273383 103 DGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVVLEF 143
Cdd:pfam13489  78 AGKFDVIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTP 118
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 27-142 2.27e-04

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 41.48  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  27 ELASEIPREGRLPVLDVATGTGDVPLALRASFPEDRRILGLDFTLPMLriAAGKLAGKGARSVSLAAGDA----FALPVR 102
Cdd:COG5459    71 ELAEAGPDFAPLTVLDVGAGPGTAAWAAADAWPSLLDATLLERSAAAL--ALGRRLARAAANPALETAEWrladLAAALP 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2108273383 103 DGAFDAVTIAFGLRNLSD--RVAALREMVRAlrPGGRVVVLE 142
Cdd:COG5459   149 APPADLVVASYVLNELADaaRAALVDRLWLA--PDGALLIVE 188
Methyltransf_2 pfam00891
O-methyltransferase domain; This family includes a range of O-methyltransferases. These ...
 37-142 4.87e-03

O-methyltransferase domain; This family includes a range of O-methyltransferases. These enzymes utilize S-adenosyl methionine.


Pssm-ID: 395719 [Multi-domain]  Cd Length: 208  Bit Score: 37.00  E-value: 4.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2108273383  37 RLPVL-DVATGTGDVPLALRASFPEDRRILgldFTLP-MLRIAAGKLAGKGARSVSLAAGDAFALPVRDGafDAVTIAFG 114
Cdd:pfam00891  60 GFRSLvDVGGGTGALAQAIVSLYPGCKGIV---FDLPhVVEAAPTHFSAGEEPRVTFHGGDFFKDSLPEA--DAYILKRV 134

                          90       100       110
                  ....*....|....*....|....*....|
gi 2108273383 115 LRNLSDR--VAALREMVRALRPGGRVVVLE 142
Cdd:pfam00891 135 LHDWSDEkcVKLLKRCYKACPAGGKVILVE 164
PLN02244 PLN02244
tocopherol O-methyltransferase
 89-140 5.18e-03

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 37.42  E-value: 5.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2108273383  89 VSLAAGDAFALPVRDGAFDAVTIAFGLRNLSDRVAALREMVRALRPGGRVVV 140
Cdd:PLN02244  170 VSFQVADALNQPFEDGQFDLVWSMESGEHMPDKRKFVQELARVAAPGGRIII 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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