VirB9/CagX/TrbG, a component of the type IV secretion system; VirB9 is a component of the type ...
7-276
6.93e-81
VirB9/CagX/TrbG, a component of the type IV secretion system; VirB9 is a component of the type IV secretion system, which is employed by pathogenic bacteria to export virulence proteins directly from the bacterial cytoplasm into the host cell. Unlike the more common type III secretion system, type IV systems evolved from the conjugative apparatus, which is used to transfer DNA between cells. VirB9 was initially identified as an essential virulence gene on the Agrobacterium tumefaciens Ti plasmid. In the pilin-like conjugative structure, VirB9 appears to form a stabilizing complex in the outer membrane, by interacting with the lipoprotein VirB7. The heterodimer has been shown to stabilize other components of the type IV system. This alignment model spans the C-terminal domain of VirB9. CagX is a component of the Helicobacter pylori cag PAI-encoded type IV secretion system. Some other members of this family are involved in conjugal transfer to T-DNA of plant cells.
The actual alignment was detected with superfamily member TIGR02781:
Pssm-ID: 448249 [Multi-domain] Cd Length: 243 Bit Score: 244.54 E-value: 6.93e-81
P-type conjugative transfer protein VirB9; The VirB9 protein is found in the vir locus of ...
7-276
6.93e-81
P-type conjugative transfer protein VirB9; The VirB9 protein is found in the vir locus of Agrobacterium Ti plasmids where it is involved in a type IV secretion system . VirB9 is a homolog of the F-type conjugative transfer system TraK protein (which is believed to be an outer membrane pore-forming secretin, TIGR02756) as well as the Ti system TrbG protein. [Cellular processes, Conjugation]
Pssm-ID: 274296 [Multi-domain] Cd Length: 243 Bit Score: 244.54 E-value: 6.93e-81
Conjugal transfer protein; This family includes type IV secretion system CagX conjugation ...
31-274
2.82e-67
Conjugal transfer protein; This family includes type IV secretion system CagX conjugation protein. Other members of this family are involved in conjugal transfer to plant cells of T-DNA.
Pssm-ID: 427348 [Multi-domain] Cd Length: 216 Bit Score: 209.06 E-value: 2.82e-67
VirB9/CagX/TrbG, a component of the type IV secretion system; VirB9 is a component of the type ...
184-275
8.32e-23
VirB9/CagX/TrbG, a component of the type IV secretion system; VirB9 is a component of the type IV secretion system, which is employed by pathogenic bacteria to export virulence proteins directly from the bacterial cytoplasm into the host cell. Unlike the more common type III secretion system, type IV systems evolved from the conjugative apparatus, which is used to transfer DNA between cells. VirB9 was initially identified as an essential virulence gene on the Agrobacterium tumefaciens Ti plasmid. In the pilin-like conjugative structure, VirB9 appears to form a stabilizing complex in the outer membrane, by interacting with the lipoprotein VirB7. The heterodimer has been shown to stabilize other components of the type IV system. This alignment model spans the C-terminal domain of VirB9. CagX is a component of the Helicobacter pylori cag PAI-encoded type IV secretion system. Some other members of this family are involved in conjugal transfer to T-DNA of plant cells.
Pssm-ID: 132874 [Multi-domain] Cd Length: 86 Bit Score: 89.56 E-value: 8.32e-23
P-type conjugative transfer protein VirB9; The VirB9 protein is found in the vir locus of ...
7-276
6.93e-81
P-type conjugative transfer protein VirB9; The VirB9 protein is found in the vir locus of Agrobacterium Ti plasmids where it is involved in a type IV secretion system . VirB9 is a homolog of the F-type conjugative transfer system TraK protein (which is believed to be an outer membrane pore-forming secretin, TIGR02756) as well as the Ti system TrbG protein. [Cellular processes, Conjugation]
Pssm-ID: 274296 [Multi-domain] Cd Length: 243 Bit Score: 244.54 E-value: 6.93e-81
Conjugal transfer protein; This family includes type IV secretion system CagX conjugation ...
31-274
2.82e-67
Conjugal transfer protein; This family includes type IV secretion system CagX conjugation protein. Other members of this family are involved in conjugal transfer to plant cells of T-DNA.
Pssm-ID: 427348 [Multi-domain] Cd Length: 216 Bit Score: 209.06 E-value: 2.82e-67
VirB9/CagX/TrbG, a component of the type IV secretion system; VirB9 is a component of the type ...
184-275
8.32e-23
VirB9/CagX/TrbG, a component of the type IV secretion system; VirB9 is a component of the type IV secretion system, which is employed by pathogenic bacteria to export virulence proteins directly from the bacterial cytoplasm into the host cell. Unlike the more common type III secretion system, type IV systems evolved from the conjugative apparatus, which is used to transfer DNA between cells. VirB9 was initially identified as an essential virulence gene on the Agrobacterium tumefaciens Ti plasmid. In the pilin-like conjugative structure, VirB9 appears to form a stabilizing complex in the outer membrane, by interacting with the lipoprotein VirB7. The heterodimer has been shown to stabilize other components of the type IV system. This alignment model spans the C-terminal domain of VirB9. CagX is a component of the Helicobacter pylori cag PAI-encoded type IV secretion system. Some other members of this family are involved in conjugal transfer to T-DNA of plant cells.
Pssm-ID: 132874 [Multi-domain] Cd Length: 86 Bit Score: 89.56 E-value: 8.32e-23
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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