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Conserved domains on  [gi|2112352108|gb|UCS26158|]
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LEU2 [Nakaseomyces glabratus]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
7-357 0e+00

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR00169:

Pssm-ID: 444908  Cd Length: 346  Bit Score: 549.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   7 IVVLPGDHVGQEITEEAIKVLNAIQEcRPDkVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKWGTG 86
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVAE-RFG-LKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  87 A--VRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPLKPEIARGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYS 164
Cdd:TIGR00169  80 PrdQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 165 VPEVQRITRMAAFMALQHNPplPIWSLDKANVLASSRLWRKTVEETIKnEFPQLTVQHQLIDSAAMILVKNPTHLNgIII 244
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 245 TNNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKLSLDLFEEG 323
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAgKGIANPIAQILSAAMLLRYSFNLEEAA 309

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2112352108 324 EIIEQAVKKVLDSGIRTADLkGTNSTTEVGDAVA 357
Cdd:TIGR00169 310 DAIEAAVKKVLAEGYRTPDL-GSSATTAVGTAEM 342
 
Name Accession Description Interval E-value
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 7-357 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 549.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   7 IVVLPGDHVGQEITEEAIKVLNAIQEcRPDkVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKWGTG 86
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVAE-RFG-LKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  87 A--VRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPLKPEIARGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYS 164
Cdd:TIGR00169  80 PrdQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 165 VPEVQRITRMAAFMALQHNPplPIWSLDKANVLASSRLWRKTVEETIKnEFPQLTVQHQLIDSAAMILVKNPTHLNgIII 244
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 245 TNNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKLSLDLFEEG 323
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAgKGIANPIAQILSAAMLLRYSFNLEEAA 309

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2112352108 324 EIIEQAVKKVLDSGIRTADLkGTNSTTEVGDAVA 357
Cdd:TIGR00169 310 DAIEAAVKKVLAEGYRTPDL-GSSATTAVGTAEM 342
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 4-363 1.22e-176

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 494.62  E-value: 1.22e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   4 TKTIVVLPGDHVGQEITEEAIKVLNAIQECRpdKVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKW 83
Cdd:PRK00772    2 TYKIAVLPGDGIGPEVMAEAVKVLDAVAEKF--GFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  84 GT--GAVRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPLKPEIARGTDFVVVRELVGGIYFGE---RKEDEGDGVAW 158
Cdd:PRK00772   80 DNlpPDVRPERGLLALRKELGLFANLRPAKLY-PGLADASPLKPEIVAGLDILIVRELTGGIYFGEprgREGLGGEERAF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 159 DSEKYSVPEVQRITRMAAFMALQHNPPLPiwSLDKANVLASSRLWRKTVEEtIKNEFPQLTVQHQLIDSAAMILVKNPTH 238
Cdd:PRK00772  159 DTMVYTREEIERIARVAFELARKRRKKVT--SVDKANVLESSRLWREVVTE-VAKEYPDVELSHMYVDNAAMQLVRNPKQ 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 239 LnGIIITNNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKLSL 317
Cdd:PRK00772  236 F-DVIVTENLFGDILSDEAAMLTGSLGMLPSASLGE-----SGPGLYEPIHGSAPDIAgKGIANPIATILSAAMMLRYSL 309

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 2112352108 318 DLFEEGEIIEQAVKKVLDSGIRTADL---KGTNSTTEVGDAVAKAVREL 363
Cdd:PRK00772  310 GLEEAADAIEAAVEKVLAQGYRTADIaegGGKVSTSEMGDAILAALAEG 358
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-356 2.06e-166

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 468.31  E-value: 2.06e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   6 TIVVLPGDHVGQEITEEAIKVLNAIQECRPDKvnFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKWGT 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLE--FEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  86 GAVRPEQGLLKIRKELQLYANLRPCNFASdSLLDLSPLKPEIaRGTDFVVVRELVGGIYFGERKEDEGDG--VAWDSEKY 163
Cdd:pfam00180  79 AGVRPENGLLALRKELGLFANLRPAKVFP-PLGDASPLKNEV-EGVDIVIVRELTGGIYFGIEKGIKGSGneVAVDTKLY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 164 SVPEVQRITRMAAFMALQHNPPlPIWSLDKANVLASSRLWRKTVEETIKNEFPQLTVQHQLIDSAAMILVKNPThLNGII 243
Cdd:pfam00180 157 SRDEIERIARVAFELARKRGRK-KVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPS-QFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 244 ITNNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKLSLDLFEE 322
Cdd:pfam00180 235 VTPNLFGDILSDEASMLTGSLGLLPSASLGA-----NGFGIFEPVHGSAPDIAgKGIANPIATILSAAMMLRYSLGLEDA 309

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2112352108 323 GEIIEQAVKKVLDSGIRTADLKGTN---STTEVGDAV 356
Cdd:pfam00180 310 ADKIEAAVLKVLESGIRTGDLAGSAtyvSTSEFGEAV 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 4-360 8.41e-158

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 446.38  E-value: 8.41e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   4 TKTIVVLPGDHVGQEITEEAIKVLNAIQECRpdKVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKW 83
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERF--GLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  84 GTGaVRPEQGLLKIRKELQLYANLRPCnfasdSLLD--LSPLKPEIARGTDFVVVRELVGGIYFGE---RKEDEGDGVAW 158
Cdd:COG0473    79 DDG-VRPESGLLALRKELDLYANLRPA-----KLYPglPSPLKPEIVEGIDLVIVRENTEGLYFGIggrIGTGTGEEVAI 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 159 DSEKYSVPEVQRITRMAAFMALQHNPPLpiWSLDKANVLA-SSRLWRKTVEEtIKNEFPQLTVQHQLIDSAAMILVKNPT 237
Cdd:COG0473   153 DTRVYTRKGIERIARYAFELARKRRKKV--TSVDKANVLKlTSGLWREVVRE-VAKEYPDVELDHMYVDAAAMQLVRNPE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 238 HLNgIIITNNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKLs 316
Cdd:COG0473   230 QFD-VIVTENLFGDILSDLAAGLTGSLGLAPSANIGD-----EGKALFEPVHGSAPDIAgKGIANPIATILSAAMMLRH- 302

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 2112352108 317 LDLFEEGEIIEQAVKKVLDSGIRTADLKGTNSTTEVGDAVAKAV 360
Cdd:COG0473   303 LGEEEAADAIEAAVEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
 
Name Accession Description Interval E-value
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 7-357 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 549.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   7 IVVLPGDHVGQEITEEAIKVLNAIQEcRPDkVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKWGTG 86
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVAE-RFG-LKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  87 A--VRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPLKPEIARGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYS 164
Cdd:TIGR00169  80 PrdQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 165 VPEVQRITRMAAFMALQHNPplPIWSLDKANVLASSRLWRKTVEETIKnEFPQLTVQHQLIDSAAMILVKNPTHLNgIII 244
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 245 TNNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKLSLDLFEEG 323
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAgKGIANPIAQILSAAMLLRYSFNLEEAA 309

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2112352108 324 EIIEQAVKKVLDSGIRTADLkGTNSTTEVGDAVA 357
Cdd:TIGR00169 310 DAIEAAVKKVLAEGYRTPDL-GSSATTAVGTAEM 342
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 4-363 1.22e-176

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 494.62  E-value: 1.22e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   4 TKTIVVLPGDHVGQEITEEAIKVLNAIQECRpdKVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKW 83
Cdd:PRK00772    2 TYKIAVLPGDGIGPEVMAEAVKVLDAVAEKF--GFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  84 GT--GAVRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPLKPEIARGTDFVVVRELVGGIYFGE---RKEDEGDGVAW 158
Cdd:PRK00772   80 DNlpPDVRPERGLLALRKELGLFANLRPAKLY-PGLADASPLKPEIVAGLDILIVRELTGGIYFGEprgREGLGGEERAF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 159 DSEKYSVPEVQRITRMAAFMALQHNPPLPiwSLDKANVLASSRLWRKTVEEtIKNEFPQLTVQHQLIDSAAMILVKNPTH 238
Cdd:PRK00772  159 DTMVYTREEIERIARVAFELARKRRKKVT--SVDKANVLESSRLWREVVTE-VAKEYPDVELSHMYVDNAAMQLVRNPKQ 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 239 LnGIIITNNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKLSL 317
Cdd:PRK00772  236 F-DVIVTENLFGDILSDEAAMLTGSLGMLPSASLGE-----SGPGLYEPIHGSAPDIAgKGIANPIATILSAAMMLRYSL 309

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 2112352108 318 DLFEEGEIIEQAVKKVLDSGIRTADL---KGTNSTTEVGDAVAKAVREL 363
Cdd:PRK00772  310 GLEEAADAIEAAVEKVLAQGYRTADIaegGGKVSTSEMGDAILAALAEG 358
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-356 2.06e-166

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 468.31  E-value: 2.06e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   6 TIVVLPGDHVGQEITEEAIKVLNAIQECRPDKvnFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKWGT 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLE--FEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  86 GAVRPEQGLLKIRKELQLYANLRPCNFASdSLLDLSPLKPEIaRGTDFVVVRELVGGIYFGERKEDEGDG--VAWDSEKY 163
Cdd:pfam00180  79 AGVRPENGLLALRKELGLFANLRPAKVFP-PLGDASPLKNEV-EGVDIVIVRELTGGIYFGIEKGIKGSGneVAVDTKLY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 164 SVPEVQRITRMAAFMALQHNPPlPIWSLDKANVLASSRLWRKTVEETIKNEFPQLTVQHQLIDSAAMILVKNPThLNGII 243
Cdd:pfam00180 157 SRDEIERIARVAFELARKRGRK-KVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPS-QFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 244 ITNNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKLSLDLFEE 322
Cdd:pfam00180 235 VTPNLFGDILSDEASMLTGSLGLLPSASLGA-----NGFGIFEPVHGSAPDIAgKGIANPIATILSAAMMLRYSLGLEDA 309

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2112352108 323 GEIIEQAVKKVLDSGIRTADLKGTN---STTEVGDAV 356
Cdd:pfam00180 310 ADKIEAAVLKVLESGIRTGDLAGSAtyvSTSEFGEAV 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 4-360 8.41e-158

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 446.38  E-value: 8.41e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   4 TKTIVVLPGDHVGQEITEEAIKVLNAIQECRpdKVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKW 83
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERF--GLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  84 GTGaVRPEQGLLKIRKELQLYANLRPCnfasdSLLD--LSPLKPEIARGTDFVVVRELVGGIYFGE---RKEDEGDGVAW 158
Cdd:COG0473    79 DDG-VRPESGLLALRKELDLYANLRPA-----KLYPglPSPLKPEIVEGIDLVIVRENTEGLYFGIggrIGTGTGEEVAI 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 159 DSEKYSVPEVQRITRMAAFMALQHNPPLpiWSLDKANVLA-SSRLWRKTVEEtIKNEFPQLTVQHQLIDSAAMILVKNPT 237
Cdd:COG0473   153 DTRVYTRKGIERIARYAFELARKRRKKV--TSVDKANVLKlTSGLWREVVRE-VAKEYPDVELDHMYVDAAAMQLVRNPE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 238 HLNgIIITNNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKLs 316
Cdd:COG0473   230 QFD-VIVTENLFGDILSDLAAGLTGSLGLAPSANIGD-----EGKALFEPVHGSAPDIAgKGIANPIATILSAAMMLRH- 302

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 2112352108 317 LDLFEEGEIIEQAVKKVLDSGIRTADLKGTNSTTEVGDAVAKAV 360
Cdd:COG0473   303 LGEEEAADAIEAAVEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 7-360 6.31e-87

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 268.48  E-value: 6.31e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   7 IVVLPGDHVGQEITEEAIKVLNAIQECRpdKVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKWGTG 86
Cdd:PLN02329   49 IALLPGDGIGPEVISVAKNVLQKAGSLE--GLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKN 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  87 A--VRPEQGLLKIRKELQLYANLRPCNFASdSLLDLSPLKPEIARGTDFVVVRELVGGIYFGERK----EDEGDGVAWDS 160
Cdd:PLN02329  127 EkhLRPEMALFYLRRDLKVFANLRPATVLP-QLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRgitiNENGEEVGVST 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 161 EKYSVPEVQRITRMAAFMALQHNPPLpiWSLDKANVLASSRLWRKTVeETIKNEFPQLTVQHQLIDSAAMILVKNPTHLN 240
Cdd:PLN02329  206 EIYAAHEIDRIARVAFETARKRRGKL--CSVDKANVLDASILWRKRV-TALASEYPDVELSHMYVDNAAMQLIRDPKQFD 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 241 gIIITNNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKLSLDL 319
Cdd:PLN02329  283 -TIVTNNIFGDILSDEASMITGSIGMLPSASLGE-----SGPGLFEPIHGSAPDIAgQDKANPLATILSAAMLLKYGLGE 356

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 2112352108 320 FEEGEIIEQAVKKVLDSGIRTADLKGTNST----TEVGDAVAKAV 360
Cdd:PLN02329  357 EKAAKRIEDAVVDALNKGFRTGDIYSPGNKlvgcKEMGEEVLKSV 401
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 5-360 1.65e-71

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 226.17  E-value: 1.65e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   5 KTIVVLPGDHVGQEITEEAIKVLNAIQecrpdkVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGgpkwg 84
Cdd:PRK14025    2 HKICVIEGDGIGKEVVPAALHVLEATG------LPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG----- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  85 tgaVRPEQGLLKIRKELQLYANLRPCNfasdSLLDLSPLKPEIargtDFVVVRELVGGIYFGErKEDEGDGVAWDSEKYS 164
Cdd:PRK14025   71 ---ETAADVIVKLRRILDTYANVRPVK----SYKGVKCLYPDI----DYVIVRENTEGLYKGI-EAEIADGVTVATRVIT 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 165 VPEVQRITRMAAFMALQHNPPL---PIWSLDKANVLA-SSRLWRKTVEEtIKNEFPQLTVQHQLIDSAAMILVKNPTHLN 240
Cdd:PRK14025  139 RKASERIFRFAFEMAKRRKKMGkegKVTCAHKANVLKkTDGLFKKTFYE-VAKEYPDIKAEDYYVDAMNMYIITRPQTFD 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 241 gIIITNNMFGDIISDEASVIPGSLGLLPSASLAslpDKNtafGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKlSLDL 319
Cdd:PRK14025  218 -VVVTSNLFGDILSDGAAGLVGGLGLAPSANIG---DKY---GLFEPVHGSAPDIAgKGIANPTATILTAVLMLR-HLGE 289

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2112352108 320 FEEGEIIEQAVKKVLDSGIRTADLKGTNSTTEVGDAVAKAV 360
Cdd:PRK14025  290 NEEADKVEKALEEVLALGLTTPDLGGNLSTMEMAEEVAKRV 330
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 1-360 7.18e-70

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 222.49  E-value: 7.18e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   1 MAVTKTIVVLPGDHVGQEITEEAIKVLNAIQECRPDkvnFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGG 80
Cdd:PRK03437    1 MAKTMKLAVIPGDGIGPEVVAEALKVLDAVAAGGPG---VETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  81 PKWGTGAVrpEQG-LLKIRKELQLYANLRPCNFASDSLldlSPLK--PEIargtDFVVVRELVGGIYFGE----RK--ED 151
Cdd:PRK03437   78 PSVPSGVL--ERGlLLKLRFALDHYVNLRPSKLYPGVT---SPLAgpGDI----DFVVVREGTEGPYTGNggalRVgtPH 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 152 EgdgVAWDSEKYSVPEVQRITRMAaFMALQHNPPLPIWSLDKANVLA-SSRLWRKTVEEtIKNEFPQLTVQHQLIDSAAM 230
Cdd:PRK03437  149 E---VATEVSVNTAFGVERVVRDA-FERAQKRPRKHLTLVHKTNVLTfAGDLWQRTVDE-VAAEYPDVTVDYQHVDAATI 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 231 ILVKNPTHLNgIIITNNMFGDIISDEASVIPGSLGLLPSASLAslPDkNTAFGLYEPCHGSAPDLP-KGKVNPVATILSA 309
Cdd:PRK03437  224 FMVTDPSRFD-VIVTDNLFGDIITDLAAAVTGGIGLAASGNIN--PT-GTNPSMFEPVHGSAPDIAgQGIADPTAAILSV 299

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2112352108 310 AMMLKlSLDLFEEGEIIEQAVKKVLdsgirTADLKGTNSTTEVGDAVAKAV 360
Cdd:PRK03437  300 ALLLD-HLGEEDAAARIEAAVEADL-----AERGKMGRSTAEVGDRIAARL 344
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 6-363 1.29e-51

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 175.29  E-value: 1.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   6 TIVVLPGDHVGQEITEEAIKVLNAIQECRpDKVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPK--- 82
Cdd:PRK08194    5 KIAVIPGDGVGKEVVPAAVRVLKAVAEVH-GGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPKlvp 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  83 -----WGTgavrpeqgLLKIRKELQLYANLRPCNFasdslldLSPLKPEIA--RGTDFVVVRELVGGIY--FGERKEDEG 153
Cdd:PRK08194   84 dhislWGL--------LIKIRREFEQVINIRPAKQ-------LRGIKSPLAnpKDFDLLVVRENSEGEYseVGGRIHRGE 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 154 DGVAWDSEKYSVPEVQRITRMAafMALQHNPPLPIWSLDKAN-VLASSRLWRKTVEETIKnEFPQLTVQHQLIDSAAMIL 232
Cdd:PRK08194  149 DEIAIQNAVFTRKGTERAMRYA--FELAAKRRKHVTSATKSNgIVHSMPFWDEVFQEVGK-DYPEIETDSQHIDALAAFF 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 233 VKNPTHLNgIIITNNMFGDIISDEASVIPGSLGLLPSASLaslpDKNTAF-GLYEPCHGSAPDLP-KGKVNPVATILSAA 310
Cdd:PRK08194  226 VTRPEEFD-VIVASNLFGDILTDIGAAIMGSIGIAPAANI----NVNGKYpSMFEPVHGSAPDIAgKGIANPIGQIWTAK 300

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2112352108 311 MMlklsLDLFEEGEI---IEQAVKKVLDSGIRTADLKGTNSTTEVGDAVAKAVREL 363
Cdd:PRK08194  301 LM----LDHFGEEELgshLLDVIEDVTEDGIKTPDIGGRATTDEVTDEIISRLKKL 352
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 4-357 2.72e-50

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 171.44  E-value: 2.72e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   4 TKTIVVLPGDHVGQEITEEAIKVLNAIQecrpdkVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKw 83
Cdd:PRK08997    2 KQTITVIPGDGIGPSIIDATLKILDKLG------CDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPV- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  84 GTGAVRPEQGLlkiRKELQLYANLRPCnfasdslldLSpLKPEIAR--GTDFVVVRELVGGIYFGERKEDEGDG-VAWDS 160
Cdd:PRK08997   75 GEGFTSINVTL---RKKFDLYANVRPV---------LS-FPGTKARydNIDIITVRENTEGMYSGEGQTVSEDGeTAEAT 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 161 EKYSVPEVQRITRMAAFMALQHNPPlPIWSLDKANVLAS-SRLWRKTVEEtIKNEFPQLTVQHQLIDSAAMILVKNPTHL 239
Cdd:PRK08997  142 SIITRKGAERIVRFAYELARKEGRK-KVTAVHKANIMKStSGLFLKVARE-VALRYPDIEFEEMIVDATCMQLVMNPEQF 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 240 NgIIITNNMFGDIISDEASVIPGSLGLLPSASLAslpdKNTAfgLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKlSLD 318
Cdd:PRK08997  220 D-VIVTTNLFGDILSDLCAGLVGGLGMAPGANIG----RDAA--IFEAVHGSAPDIAgKNLANPTSVILAAIQMLE-YLG 291

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2112352108 319 LFEEGEIIEQAVKKVLDSGIR-TADLKGTNSTTEVGDAVA 357
Cdd:PRK08997  292 MPDKAERIRKAIVAVIEAGDRtTRDLGGTHGTTDFTQAVI 331
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 6-356 7.00e-37

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 136.93  E-value: 7.00e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   6 TIVVLPGDHVGQEITEEAIKVLNAIqecrpdKVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPkWGT 85
Cdd:PLN00118   43 TATLFPGDGIGPEIAESVKQVFTAA------GVPIEWEEHYVGTTVDPRTGSFLTWESLESVRRNKVGLKGPMATP-IGK 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  86 GavrpEQGL-LKIRKELQLYANLRPCNfasdSLldlsPLKPEIARGTDFVVVRelvggiyfgERKEDEGDGVAWDSEKYS 164
Cdd:PLN00118  116 G----HRSLnLTLRKELGLYANVRPCY----SL----PGYKTRYDDVDLVTIR---------ENTEGEYSGLEHQVVRGV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 165 VPEVQRITRMA-------AFMALQHNPPLPIWSLDKANVLASSR-LWRKTVEEtIKNEFPQLTVQHQLIDSAAMILVKNP 236
Cdd:PLN00118  175 VESLKIITRQAslrvaeyAFHYAKTHGRKRVSAIHKANIMKKTDgLFLKCCRE-VAEKYPEIVYEEVIIDNCCMMLVKNP 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 237 ThLNGIIITNNMFGDIISDEASVIPGSLGLLPSASLAslpdkNTAFGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKl 315
Cdd:PLN00118  254 A-LFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIG-----ENGLALAEAVHGSAPDIAgKNLANPTALLLSAVMMLR- 326

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2112352108 316 SLDLFEEGEIIEQAVKKVLDSG-IRTADLKGTNSTTEVGDAV 356
Cdd:PLN00118  327 HLKLNEQAEQIHNAILNTIAEGkYRTADLGGSSTTTDFTKAI 368
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-356 4.55e-35

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 133.86  E-value: 4.55e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   1 MAVTKTIVVLPGDHVGQEITEEAIKVLNAIQ-ECRPDKVN-----FKFEHhliggaaidATGVPlpDEALEASKKADAVL 74
Cdd:PRK09222    1 MAEKTPITVAYGDGIGPEIMEAVLKILEAAGaPLEIETIEigekvYKKGW---------TSGIS--PSAWESIRRTKVLL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  75 LGAVGGPKwGTGavrpEQGL-LKIRKELQLYANLRPCnfasdslLDLSPLKPEIARGTDFVVVRE----LVGGIyfgERK 149
Cdd:PRK09222   70 KAPITTPQ-GGG----YKSLnVTLRKTLGLYANVRPC-------VSYHPFVETKHPNLDVVIIREneedLYAGI---EHR 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 150 edEGDGVAWDSEKYSVPEVQRITRMAAFMALQHNPPlPIWSLDKANVLASSRLWRKTVEETIKNEFPQLTVQHQLIDSAA 229
Cdd:PRK09222  135 --QTPDVYQCLKLISRPGSEKIIRYAFEYARANGRK-KVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGA 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 230 MILVKNPTHLNgIIITNNMFGDIISDEASVIPGSLGLLPSASLASlpdkntAFGLYEPCHGSAPDLP-KGKVNPVATILS 308
Cdd:PRK09222  212 ARLATNPENFD-VIVTPNLYGDILSDIAAEISGSVGLAGSANIGE------EYAMFEAVHGSAPDIAgKNIANPSGLLNA 284

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2112352108 309 AAMMLkLSLDLFEEGEIIEQAVKKVLDSGIRTADL------KGTNSTTEVGDAV 356
Cdd:PRK09222  285 AVMML-VHIGQFDIAELIENAWLKTLEDGIHTADIynegvsKKKVGTKEFAEAV 337
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 6-358 4.75e-30

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 118.68  E-value: 4.75e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   6 TIVVLPGDHVGQEITEEAIKVLN-AIQECRPDKVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGA----VGG 80
Cdd:COG0538    20 IIPFIEGDGIGPEITRAIWKVIDaAVEKAYGGKRDIEWKEVDAGEKARDETGDWLPDETAEAIKEYGVGIKGPlttpVGG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  81 pKW----GTgavrpeqgllkIRKELQLYANLRPCNFASDSLldlSPLK-PEIargTDFVVVRELVGGIYFG--------E 147
Cdd:COG0538   100 -GWrslnVT-----------IRQILDLYVCRRPVRYFKGVP---SPVKhPEK---VDIVIFRENTEDIYAGiewkagspE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 148 RKE-----DEGDGVawdsEKYSVPE-------------VQRITRMAAFMALQHNPPlPIWSLDKANVLassrlwrKTVE- 208
Cdd:COG0538   162 ALKlifflEDEMGV----TVIRFPEdsgigikpvsdegTERLVRAAIQYALDNKRK-SVTLVHKGNIM-------KFTEg 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 209 -------ETIKNEFP-------------------QLTVQHQLIDSAAMILVKNPTHLNgIIITNNMFGDIISDEASVIPG 262
Cdd:COG0538   230 afkdwgyEVAEEEFGdkfitegpwekykgpkpagKIVYKDRIADDMLQQILLRPGEYD-VIATKNLNGDYISDALAAQVG 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 263 SLGLLPSASLAslPDkntAFGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKLsLDLFEEGEIIEQAVKKVLDSGIRTA 341
Cdd:COG0538   309 GLGIAPGANIG--DD---GGAEFEATHGTAPKYAgKDSTNPGSLILSGTMMLRH-RGWLEAADLIEKAVEKTIESGKVTY 382

                         410       420
                  ....*....|....*....|...
gi 2112352108 342 DL----KGTN--STTEVGDAVAK 358
Cdd:COG0538   383 DLarlmEGATelSTSEFGDAIIE 405
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 5-356 8.95e-24

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 100.71  E-value: 8.95e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   5 KTIVVLPGDHVGQEITEEAIKVLNAIQEcrpdKVNF-KFEHHliGGAAidatgvPLPDEALEASKKADAVLLGAVGGPKw 83
Cdd:PLN00123   31 RAVTLIPGDGIGPLVTGAVEQVMEAMHA----PVYFeRYEVH--GDMK------KVPEEVLESIRRNKVCLKGGLATPV- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  84 GTGAvrpeQGL-LKIRKELQLYANLRPC-NFasdslldlsPLKPEIARGTDFVVVRELVGGIYFGERKEDEgDGVAwDSE 161
Cdd:PLN00123   98 GGGV----SSLnVQLRKELDLFASLVNCfNL---------PGLPTRHENVDIVVIRENTEGEYSGLEHEVV-PGVV-ESL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 162 KYSVPEVQRITRMAAFMALQHNPPLPIWSLDKANVLA-SSRLWRKTVEETIKNeFPQLTVQHQLIDSAAMILVKNPTHLN 240
Cdd:PLN00123  163 KVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKlADGLFLESCREVAKK-YPGIKYNEIIVDNCCMQLVSKPEQFD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 241 gIIITNNMFGDIISDEASVIPGSLGLLPSASLAslpDKNTAF--GLYEPCHGSAPDLPKGKVNPVATILSAAMMLKlSLD 318
Cdd:PLN00123  242 -VMVTPNLYGNLVANTAAGIAGGTGVMPGGNVG---ADHAVFeqGASAGNVGNEKLVEQKKANPVALLLSSAMMLR-HLQ 316

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2112352108 319 LFEEGEIIEQAVKKVLDSG-IRTADLKGTNSTTEVGDAV 356
Cdd:PLN00123  317 FPSFADRLETAVKRVIAEGkYRTKDLGGSSTTQEVVDAV 355
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
7-363 1.59e-21

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 94.90  E-value: 1.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108   7 IVVLPGDHVGQEITEEAIKVLN-AIQECRPDKVNFKFEHHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGP---K 82
Cdd:PRK06451   26 ILYVEGDGIGPEITHAAMKVINkAVEKAYGSDREIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPigkG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  83 WGTGAVRpeqgllkIRKELQLYANLRPCNFASDslLDlSPLK-PEiarGTDFVVVRELVGGIYFG--------------- 146
Cdd:PRK06451  106 WKSINVA-------IRLMLDLYANIRPVKYIPG--IE-SPLKnPE---KIDLIIFRENTDDLYRGieypydseeakkird 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 147 --------ERKEDEGDGVAWDSeKYsvpEVQRITRMAAFMALQHNPPlPIWSLDKANVLASSR-LWRKTVEETIKNEFPQ 217
Cdd:PRK06451  173 flrkelgvEVEDDTGIGIKLIS-KF---KTQRIARMAIKYAIDHKRK-KVTIMHKGNVMKYTEgAFREWAYEVALKEFRD 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 218 LTVQHQLIDSAAMILVKNPTHLNGIIITNNMF-------------------GDIISDEASVIPGSLGLLPSASLAslpdk 278
Cdd:PRK06451  248 YVVTEEEVTKNYNGVPPSGKVIINDRIADNMFqqiiirpdeydiilapnvnGDYISDAAGALVGNIGMLGGANIG----- 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 279 NTAfGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKLsLDLFEEGEIIEQAVKKVLDSGIRTADLK---GTN--STTEV 352
Cdd:PRK06451  323 DTG-GMFEAIHGTAPKYAgKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLArfmGVRalSTTEY 400

                         410
                  ....*....|.
gi 2112352108 353 GDAVAKAVREL 363
Cdd:PRK06451  401 TDELISIIDML 411
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 12-358 2.21e-15

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 76.64  E-value: 2.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  12 GDHVGQEITEEAIKVLNA-IQECRPDKVNFKFEHHLIGGAAIDATG--VPLPDEALEASKKadavLLGAVGGPkWGT--- 85
Cdd:PRK07006   27 GDGIGPDITPAMLKVVDAaVEKAYKGERKISWMEIYAGEKATKVYGedVWLPEETLDLIRE----YRVAIKGP-LTTpvg 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108  86 GAVRPEQglLKIRKELQLYANLRPCNFASDSLldlSPLK-PEIargTDFVVVRELVGGIYfgerkedegDGVAWDSEKys 164
Cdd:PRK07006  102 GGIRSLN--VALRQELDLYVCLRPVRYFKGVP---SPVKrPED---TDMVIFRENSEDIY---------AGIEWKAGS-- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 165 vPEVQRITRMaafmaLQ-----------HNPPLPIWSLDKAnvlASSRLWRKTVEETIKNEFPQLTVQH----------- 222
Cdd:PRK07006  163 -AEAKKVIKF-----LQeemgvkkirfpETSGIGIKPVSEE---GTERLVRAAIEYAIDNDRKSVTLVHkgnimkftega 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 223 ---------------QLIDSAAMILVKNPTHLNGIII-----------------------TNNMFGDIISDEASVIPGSL 264
Cdd:PRK07006  234 fkdwgyqlaeeefgdELIDGGPWDKIKNPETGKEIIVkdsiadaflqqillrpaeydviaTMNLNGDYISDALAAQVGGI 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 265 GLLPSASLaslpdkNTAFGLYEPCHGSAPDLP-KGKVNPVATILSAAMMLKlSLDLFEEGEIIEQAVKKVLDSGIRTAD- 342
Cdd:PRK07006  314 GIAPGANI------NDGHAIFEATHGTAPKYAgLDKVNPGSVILSAEMMLR-HMGWTEAADLIIKSMEKTIASKTVTYDf 386

                         410       420
                  ....*....|....*....|.
gi 2112352108 343 ---LKGTN--STTEVGDAVAK 358
Cdd:PRK07006  387 arlMEGATevKCSEFGDALIK 407
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
242-343 4.29e-07

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 51.64  E-value: 4.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112352108 242 IIITNNMFGDIISDEASVIPGSLGLLPSASLAslpDKNTAFglyEPCHGSAPDLPK-GKVNPVATILSAAMMLKLsLDLF 320
Cdd:PRK07362  355 ILATLNLNGDYISDAAAAIVGGLGMAPGANIG---DNAAIF---EATHGTAPKHAGlDRINPGSVILSGVMMLEY-LGWQ 427

                          90       100
                  ....*....|....*....|...
gi 2112352108 321 EEGEIIEQAVKKVLDSGIRTADL 343
Cdd:PRK07362  428 EAADLITKGLSAAIANKQVTYDL 450
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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