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Conserved domains on  [gi|2112366036|gb|UCS37093|]
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uncharacterized protein HLK62_I03751 [Nakaseomyces glabratus]

Protein Classification

mediator of RNA polymerase II transcription subunit 17( domain architecture ID 10562700)

mediator of RNA polymerase II transcription subunit 17 (MED17) is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med17 pfam10156
Subunit 17 of Mediator complex; This Mediator complex subunit was formerly known as Srb4 in ...
 8-564 0e+00

Subunit 17 of Mediator complex; This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.


:

Pssm-ID: 401965  Cd Length: 441  Bit Score: 538.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036   8 TDELHSIRLAIDPNLITLPIgskstsphsnstsdgnpeshnteneevdnkagslppeqfsnnsaklivnpYEKYGRMSLG 87
Cdd:pfam10156   1 STKESGIPLSLDPNLINLPL--------------------------------------------------YEVFGQMPLA 30

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036  88 QLIPLISQQRGPnfkFADINEDILKQELAIENDNGKQESKDDTKAEDgiDTMDIDQNDnseantndigynewsnepkedt 167
Cdd:pfam10156  31 QLIPRILQERGP---FRDLTEESLREEIEAEKQSPEDEDKSEGEEED--DEMKIDVED---------------------- 83

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036 168 gildntqdtningemeSQLTQEEFNKIRKVMLEHINMAMNESSLAMEFVSLLLSPVRESTAVSSMSPFLKKTVNPGSLNS 247
Cdd:pfam10156  84 ----------------TMMTQEEFAKARKEMIEHINMALNESSLALDFISLLLSKVRESQAASSMSPFLKKTVPPGSLNS 147

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036 248 EKVKMPAVSRRDKLSLSILSRGWKLRALNEARAILKKNFTEISSSLKQEHHYWSSIaynISNKDVLFKIRDKQTTKRSLG 327
Cdd:pfam10156 148 DKVPAPPKTKAEKLELALLNKGWKLKSLNEARDLLKEAAARLEKEVEKEHKYWEEI---ISNSDVGWKIRDKPTGKRSLG 224

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036 328 LKYGYEDSGSTFRnDRGTAILRGTDEANGLELIPLtlgrtstvgsVYKGGKFLRVRIFTKiesEGDYILSGESSLDklfk 407
Cdd:pfam10156 225 VKYGYEDAGSTFK-DRGLAPLRRNPEGSILLLVPI----------LGSKEKFLRVRIFTK---EDDYILSGESSLP---- 286

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036 408 nhsENSDSKNDDVRLQISKLKFFIFEQELMHQLKKECAYLISYGVTVENeHKIVIELPNEKFEIEYLSLDDDSVVNHEQD 487
Cdd:pfam10156 287 ---TLLKSDDSDIRKQIEKARNTIFEEELMYELKKEARQLISYGVSFEN-NKIVIELPNEKIEIELVSLDDSSPVNHEQD 362

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2112366036 488 APKANDRRANLMLVTLRMLLIVIYKKNLRQKMVSN--TRKHIASTEKDILLIRPLLGKMRHSNHKKLIRKILKECVLEV 564
Cdd:pfam10156 363 APKPNDKRANLILITLRLLLVVIFRKNLRRRLPPPktAAKRSRSPPKDILLLRPILGKLRHQNYKSLLRKILKTLVLTL 441
 
Name Accession Description Interval E-value
Med17 pfam10156
Subunit 17 of Mediator complex; This Mediator complex subunit was formerly known as Srb4 in ...
 8-564 0e+00

Subunit 17 of Mediator complex; This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.


Pssm-ID: 401965  Cd Length: 441  Bit Score: 538.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036   8 TDELHSIRLAIDPNLITLPIgskstsphsnstsdgnpeshnteneevdnkagslppeqfsnnsaklivnpYEKYGRMSLG 87
Cdd:pfam10156   1 STKESGIPLSLDPNLINLPL--------------------------------------------------YEVFGQMPLA 30

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036  88 QLIPLISQQRGPnfkFADINEDILKQELAIENDNGKQESKDDTKAEDgiDTMDIDQNDnseantndigynewsnepkedt 167
Cdd:pfam10156  31 QLIPRILQERGP---FRDLTEESLREEIEAEKQSPEDEDKSEGEEED--DEMKIDVED---------------------- 83

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036 168 gildntqdtningemeSQLTQEEFNKIRKVMLEHINMAMNESSLAMEFVSLLLSPVRESTAVSSMSPFLKKTVNPGSLNS 247
Cdd:pfam10156  84 ----------------TMMTQEEFAKARKEMIEHINMALNESSLALDFISLLLSKVRESQAASSMSPFLKKTVPPGSLNS 147

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036 248 EKVKMPAVSRRDKLSLSILSRGWKLRALNEARAILKKNFTEISSSLKQEHHYWSSIaynISNKDVLFKIRDKQTTKRSLG 327
Cdd:pfam10156 148 DKVPAPPKTKAEKLELALLNKGWKLKSLNEARDLLKEAAARLEKEVEKEHKYWEEI---ISNSDVGWKIRDKPTGKRSLG 224

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036 328 LKYGYEDSGSTFRnDRGTAILRGTDEANGLELIPLtlgrtstvgsVYKGGKFLRVRIFTKiesEGDYILSGESSLDklfk 407
Cdd:pfam10156 225 VKYGYEDAGSTFK-DRGLAPLRRNPEGSILLLVPI----------LGSKEKFLRVRIFTK---EDDYILSGESSLP---- 286

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036 408 nhsENSDSKNDDVRLQISKLKFFIFEQELMHQLKKECAYLISYGVTVENeHKIVIELPNEKFEIEYLSLDDDSVVNHEQD 487
Cdd:pfam10156 287 ---TLLKSDDSDIRKQIEKARNTIFEEELMYELKKEARQLISYGVSFEN-NKIVIELPNEKIEIELVSLDDSSPVNHEQD 362

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2112366036 488 APKANDRRANLMLVTLRMLLIVIYKKNLRQKMVSN--TRKHIASTEKDILLIRPLLGKMRHSNHKKLIRKILKECVLEV 564
Cdd:pfam10156 363 APKPNDKRANLILITLRLLLVVIFRKNLRRRLPPPktAAKRSRSPPKDILLLRPILGKLRHQNYKSLLRKILKTLVLTL 441
 
Name Accession Description Interval E-value
Med17 pfam10156
Subunit 17 of Mediator complex; This Mediator complex subunit was formerly known as Srb4 in ...
 8-564 0e+00

Subunit 17 of Mediator complex; This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.


Pssm-ID: 401965  Cd Length: 441  Bit Score: 538.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036   8 TDELHSIRLAIDPNLITLPIgskstsphsnstsdgnpeshnteneevdnkagslppeqfsnnsaklivnpYEKYGRMSLG 87
Cdd:pfam10156   1 STKESGIPLSLDPNLINLPL--------------------------------------------------YEVFGQMPLA 30

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036  88 QLIPLISQQRGPnfkFADINEDILKQELAIENDNGKQESKDDTKAEDgiDTMDIDQNDnseantndigynewsnepkedt 167
Cdd:pfam10156  31 QLIPRILQERGP---FRDLTEESLREEIEAEKQSPEDEDKSEGEEED--DEMKIDVED---------------------- 83

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036 168 gildntqdtningemeSQLTQEEFNKIRKVMLEHINMAMNESSLAMEFVSLLLSPVRESTAVSSMSPFLKKTVNPGSLNS 247
Cdd:pfam10156  84 ----------------TMMTQEEFAKARKEMIEHINMALNESSLALDFISLLLSKVRESQAASSMSPFLKKTVPPGSLNS 147

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036 248 EKVKMPAVSRRDKLSLSILSRGWKLRALNEARAILKKNFTEISSSLKQEHHYWSSIaynISNKDVLFKIRDKQTTKRSLG 327
Cdd:pfam10156 148 DKVPAPPKTKAEKLELALLNKGWKLKSLNEARDLLKEAAARLEKEVEKEHKYWEEI---ISNSDVGWKIRDKPTGKRSLG 224

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036 328 LKYGYEDSGSTFRnDRGTAILRGTDEANGLELIPLtlgrtstvgsVYKGGKFLRVRIFTKiesEGDYILSGESSLDklfk 407
Cdd:pfam10156 225 VKYGYEDAGSTFK-DRGLAPLRRNPEGSILLLVPI----------LGSKEKFLRVRIFTK---EDDYILSGESSLP---- 286

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2112366036 408 nhsENSDSKNDDVRLQISKLKFFIFEQELMHQLKKECAYLISYGVTVENeHKIVIELPNEKFEIEYLSLDDDSVVNHEQD 487
Cdd:pfam10156 287 ---TLLKSDDSDIRKQIEKARNTIFEEELMYELKKEARQLISYGVSFEN-NKIVIELPNEKIEIELVSLDDSSPVNHEQD 362

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2112366036 488 APKANDRRANLMLVTLRMLLIVIYKKNLRQKMVSN--TRKHIASTEKDILLIRPLLGKMRHSNHKKLIRKILKECVLEV 564
Cdd:pfam10156 363 APKPNDKRANLILITLRLLLVVIFRKNLRRRLPPPktAAKRSRSPPKDILLLRPILGKLRHQNYKSLLRKILKTLVLTL 441
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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