NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2126660401|gb|UDV87711|]
View 

helix-turn-helix transcriptional regulator [Bacillus cereus]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
1-104 3.29e-39

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 126.14  E-value: 3.29e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2126660401   1 MEHNSCLCPkFESAFTLLSKKWTGLIIKSLLEESKRFREIADIIPNMSDRMLSERLKELESEGIVVRNVYPEVPVRIEYG 80
Cdd:COG1733     3 KDLKEADCP-VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYS 81

                          90       100
                  ....*....|....*....|....
gi 2126660401  81 LTDKGKALESVMDEVQNWAEKWMK 104
Cdd:COG1733    82 LTEKGRSLLPVLDALAEWGEEHLP 105
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
1-104 3.29e-39

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 126.14  E-value: 3.29e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2126660401   1 MEHNSCLCPkFESAFTLLSKKWTGLIIKSLLEESKRFREIADIIPNMSDRMLSERLKELESEGIVVRNVYPEVPVRIEYG 80
Cdd:COG1733     3 KDLKEADCP-VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYS 81

                          90       100
                  ....*....|....*....|....
gi 2126660401  81 LTDKGKALESVMDEVQNWAEKWMK 104
Cdd:COG1733    82 LTEKGRSLLPVLDALAEWGEEHLP 105
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 17-103 3.81e-34

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 112.78  E-value: 3.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2126660401  17 LLSKKWTGLIIKSLLEESKRFREIADIIPNMSDRMLSERLKELESEGIVVRNVYPEVPVRIEYGLTDKGKALESVMDEVQ 96
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*..
gi 2126660401  97 NWAEKWM 103
Cdd:pfam01638  81 DWGEEYL 87
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 15-96 2.05e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 41.90  E-value: 2.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2126660401  15 FTLLSKKWTGLIIKSLLEESKRFREIADIIpNMSDRMLSERLKELESEGIVVRNvypEVPVRIEYGLTDKGKALESVMDE 94
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTDAERLLALLESL 76


                  ..
gi 2126660401  95 VQ 96
Cdd:cd00090    77 LE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
26-83 2.06e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 33.72  E-value: 2.06e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2126660401   26 IIKSLLEESKRFREIADIIpNMSDRMLSERLKELESEGIVVRNvypEVPVRIEYGLTD 83
Cdd:smart00418   2 ILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVESR---REGKRVYYSLTD 55
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
1-104 3.29e-39

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 126.14  E-value: 3.29e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2126660401   1 MEHNSCLCPkFESAFTLLSKKWTGLIIKSLLEESKRFREIADIIPNMSDRMLSERLKELESEGIVVRNVYPEVPVRIEYG 80
Cdd:COG1733     3 KDLKEADCP-VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYS 81

                          90       100
                  ....*....|....*....|....
gi 2126660401  81 LTDKGKALESVMDEVQNWAEKWMK 104
Cdd:COG1733    82 LTEKGRSLLPVLDALAEWGEEHLP 105
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 17-103 3.81e-34

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 112.78  E-value: 3.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2126660401  17 LLSKKWTGLIIKSLLEESKRFREIADIIPNMSDRMLSERLKELESEGIVVRNVYPEVPVRIEYGLTDKGKALESVMDEVQ 96
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*..
gi 2126660401  97 NWAEKWM 103
Cdd:pfam01638  81 DWGEEYL 87
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 15-96 2.05e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 41.90  E-value: 2.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2126660401  15 FTLLSKKWTGLIIKSLLEESKRFREIADIIpNMSDRMLSERLKELESEGIVVRNvypEVPVRIEYGLTDKGKALESVMDE 94
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTDAERLLALLESL 76


                  ..
gi 2126660401  95 VQ 96
Cdd:cd00090    77 LE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
26-83 2.06e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 33.72  E-value: 2.06e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2126660401   26 IIKSLLEESKRFREIADIIpNMSDRMLSERLKELESEGIVVRNvypEVPVRIEYGLTD 83
Cdd:smart00418   2 ILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVESR---REGKRVYYSLTD 55
COG3888 COG3888
Predicted transcriptional regulator [Transcription];
46-67 6.54e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 443096 [Multi-domain]  Cd Length: 328  Bit Score: 34.23  E-value: 6.54e-03
                          10        20
                  ....*....|....*....|..
gi 2126660401  46 NMSDRMLSERLKELESEGIVVR 67
Cdd:COG3888    30 GASKSRVSEILSELEKEGLIAR 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH