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Conserved domains on  [gi|2136273316|gb|UEP95011|]
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peptide chain release factor 2 [Bacillus pacificus]

Protein Classification

PCRF domain-containing protein; peptide chain release factor 2( domain architecture ID 11482407)

peptide chain release factor (PCRF) domain-containing protein similar to Homo sapiens mitochondrial peptide chain release factor 1 (MTRF1), MTRF1-like and 28S mitochondrial ribosomal protein S35 (MRPS35)| peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 40-365 0e+00

peptide chain release factor 2; Provisional


:

Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 647.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316  40 MMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLS 119
Cdd:PRK06746    1 MMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 120 DPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHR 199
Cdd:PRK06746   81 DPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 200 LVRISPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQ 279
Cdd:PRK06746  161 LVRISPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 280 IKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDA 359
Cdd:PRK06746  241 IKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDA 320


                  ....*.
gi 2136273316 360 YLRSRI 365
Cdd:PRK06746  321 YLRSRI 326
 
Name Accession Description Interval E-value
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 40-365 0e+00

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 647.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316  40 MMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLS 119
Cdd:PRK06746    1 MMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 120 DPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHR 199
Cdd:PRK06746   81 DPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 200 LVRISPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQ 279
Cdd:PRK06746  161 LVRISPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 280 IKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDA 359
Cdd:PRK06746  241 IKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDA 320


                  ....*.
gi 2136273316 360 YLRSRI 365
Cdd:PRK06746  321 YLRSRI 326
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 2-364 0e+00

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 569.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316   2 ELVEIRQELEKMAKRLAAFRGSLDLPTKEKQIAELEEKMMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEI 81
Cdd:TIGR00020   1 EINEVNNRIEDLTSRLDTVRGSLDPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316  82 THELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLSDPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFK 161
Cdd:TIGR00020  81 LLELAVEEDDEETFNELDAELKALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 162 VETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKID 241
Cdd:TIGR00020 161 VEIIDYSEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRID 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 242 TYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQ 321
Cdd:TIGR00020 241 TYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGSQ 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 2136273316 322 IRSYVFHPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDAYLRSR 364
Cdd:TIGR00020 321 IRSYVLHPYSMVKDLRTGYETGNVQAVLDGDIDQFIEAYLKWK 363
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 6-359 8.21e-118

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 345.45  E-value: 8.21e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316   6 IRQELEKMAKRLAafrgsldlptkekqiaELEEKMMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHEL 85
Cdd:COG0216     2 MLDKLEALEERYE----------------ELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKEL 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316  86 LKEEYDEDLHEELESEVKGLIQEMNEYE--LQLLL--SDPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFK 161
Cdd:COG0216    66 LEEESDPEMREMAKEELEELEARLEELEeeLKILLlpKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWK 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 162 VETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVSCEVVPEFnDEVEIEVRTEDLKID 241
Cdd:COG0216   146 VEILSASEGELGGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEA-EEVDVEINPKDLRID 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 242 TYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQkeIGWG-- 319
Cdd:COG0216   225 TFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQ--VGSGdr 302

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2136273316 320 SQ-IRSYVFhPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDA 359
Cdd:COG0216   303 SErIRTYNF-PQGRVTDHRINLTLYKLDEVMEGDLDELIDA 342
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 29-218 5.93e-83

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 250.38  E-value: 5.93e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316  29 KEKQIAELEEKMMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKeeyDEDLHEELESEVKGLIQE 108
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE---DPELAELAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 109 MNEY--ELQLLLS--DPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKG 184
Cdd:pfam03462  78 LEELeeELKLLLLpkDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2136273316 185 HNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS 218
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFAT 191
PCRF smart00937
This domain is found in peptide chain release factors;
84-194 5.86e-52

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 168.41  E-value: 5.86e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316   84 ELLKEEYDEDLHEELESEV----KGLIQEMNEYELQLLLS-DPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKR 158
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELeeleAELEEELEELLKLLLLPkDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2136273316  159 GFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAE 194
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 40-365 0e+00

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 647.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316  40 MMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLS 119
Cdd:PRK06746    1 MMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 120 DPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHR 199
Cdd:PRK06746   81 DPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 200 LVRISPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQ 279
Cdd:PRK06746  161 LVRISPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 280 IKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDA 359
Cdd:PRK06746  241 IKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDA 320


                  ....*.
gi 2136273316 360 YLRSRI 365
Cdd:PRK06746  321 YLRSRI 326
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 2-364 0e+00

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 569.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316   2 ELVEIRQELEKMAKRLAAFRGSLDLPTKEKQIAELEEKMMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEI 81
Cdd:TIGR00020   1 EINEVNNRIEDLTSRLDTVRGSLDPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316  82 THELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLSDPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFK 161
Cdd:TIGR00020  81 LLELAVEEDDEETFNELDAELKALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 162 VETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKID 241
Cdd:TIGR00020 161 VEIIDYSEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRID 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 242 TYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQ 321
Cdd:TIGR00020 241 TYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGSQ 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 2136273316 322 IRSYVFHPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDAYLRSR 364
Cdd:TIGR00020 321 IRSYVLHPYSMVKDLRTGYETGNVQAVLDGDIDQFIEAYLKWK 363
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 40-363 3.47e-162

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 456.96  E-value: 3.47e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316  40 MMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEyDEDLHEELESEVKGLIQEMNEYELQLLLS 119
Cdd:PRK05589    1 MQEPNFWNDIKEAQEITSEEKYLKDKLDKYNHLRNRIEDIEVLCEMMSEE-DDEMKKEIISEVKNIKEEIDRFKIETLLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 120 DPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHR 199
Cdd:PRK05589   80 GEYDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 200 LVRISPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQ 279
Cdd:PRK05589  160 LVRISPFNANGKRQTSFASVEVLPELTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQ 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 280 IKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDA 359
Cdd:PRK05589  240 HSNKETAMKMLKSKLVELKERAHKEKIEDLTGELKDMGWGSQIRSYVFHPYNLVKDHRTGVETSNVDSVMDGDIDNFITQ 319


                  ....
gi 2136273316 360 YLRS 363
Cdd:PRK05589  320 YLKG 323
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 43-365 7.08e-135

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 388.08  E-value: 7.08e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316  43 AGFWDDQQGAQAVINEANALKDMVGKFRQLDETFE-NLEIThELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLSDP 121
Cdd:PRK07342    6 PSLWNDAQEAQKLMRERQQLDDSINGINHLEQTLNdNIELI-AMGEEEGDKSIVEDAEKTIRDLKDEIDRRQIDALLSGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 122 YDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLV 201
Cdd:PRK07342   85 ADANDTYLEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGVHRLV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 202 RISPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIK 281
Cdd:PRK07342  165 RISPYDSNARRHTSFASIWVYPVIDDNIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHK 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 282 NREHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDAYL 361
Cdd:PRK07342  245 NRAKAWSMLRARLYEEELKKREEATNAAAASKTDIGWGHQIRSYVLQPYQLVKDLRTGVESTNPQDVLDGDLNEFMEAAL 324


                  ....
gi 2136273316 362 RSRI 365
Cdd:PRK07342  325 AHRI 328
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 6-359 8.21e-118

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 345.45  E-value: 8.21e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316   6 IRQELEKMAKRLAafrgsldlptkekqiaELEEKMMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHEL 85
Cdd:COG0216     2 MLDKLEALEERYE----------------ELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKEL 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316  86 LKEEYDEDLHEELESEVKGLIQEMNEYE--LQLLL--SDPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFK 161
Cdd:COG0216    66 LEEESDPEMREMAKEELEELEARLEELEeeLKILLlpKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWK 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 162 VETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVSCEVVPEFnDEVEIEVRTEDLKID 241
Cdd:COG0216   146 VEILSASEGELGGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEA-EEVDVEINPKDLRID 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 242 TYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQkeIGWG-- 319
Cdd:COG0216   225 TFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQ--VGSGdr 302

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2136273316 320 SQ-IRSYVFhPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDA 359
Cdd:COG0216   303 SErIRTYNF-PQGRVTDHRINLTLYKLDEVMEGDLDELIDA 342
prfA PRK00591
peptide chain release factor 1; Validated
 30-359 2.15e-117

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 344.37  E-value: 2.15e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316  30 EKQIAELEEKMMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEM 109
Cdd:PRK00591   12 EERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAKEELKELEERL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 110 NEYE--LQLLL--SDPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGH 185
Cdd:PRK00591   92 EELEeeLKILLlpKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKEVIAEISGD 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 186 NAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVSCEVVPEFnDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHT 265
Cdd:PRK00591  172 GVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEA-EEVEVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHL 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 266 PTNTVVTCQSERSQIKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQkeIGWGS---QIRSYVFhPYSLVKDHRTNTEV 342
Cdd:PRK00591  251 PTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQ--VGSGDrseRIRTYNF-PQGRVTDHRINLTL 327

                         330
                  ....*....|....*..
gi 2136273316 343 GNVQAVMDGEIDPFIDA 359
Cdd:PRK00591  328 YKLDEVMEGDLDELIDA 344
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 84-363 6.23e-111

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 326.23  E-value: 6.23e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316  84 ELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLSDPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVE 163
Cdd:PRK08787   24 DLAESEQDEDTALAVIADLDKYQAHVEKLEFQRMFSGQMDGANAFVDIQAGAGGTEAQDWAEILLRMYLRWAESRGWKTE 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 164 TVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTY 243
Cdd:PRK08787  104 LMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEVDDNIEIDINPADLRTDVY 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 244 RASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIR 323
Cdd:PRK08787  184 RSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYELEVQKRNAEKDALEATKSDIGWGSQIR 263

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2136273316 324 SYVFHPySLVKDHRTNTEVGNVQAVMDGEIDPFIDAYLRS 363
Cdd:PRK08787  264 NYVLDQ-SRIKDLRTGIERSDTQKVLDGDLDEFVEASLKA 302
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 29-218 5.93e-83

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 250.38  E-value: 5.93e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316  29 KEKQIAELEEKMMGAGFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKeeyDEDLHEELESEVKGLIQE 108
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE---DPELAELAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 109 MNEY--ELQLLLS--DPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKG 184
Cdd:pfam03462  78 LEELeeELKLLLLpkDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2136273316 185 HNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS 218
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFAT 191
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 227-337 2.82e-66

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 204.96  E-value: 2.82e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 227 DEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKLYQKKLEEQQAEL 306
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKK 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2136273316 307 DEIRGEQKEIGWGSQIRSYVFHPYSLVKDHR 337
Cdd:pfam00472  81 RRIKSQVGSGDRSEQIRTYNFKPQSRVKDHR 111
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 230-344 2.46e-52

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 170.31  E-value: 2.46e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 230 EIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITH------------TPTNTVVTCQSERSQIKNREHAMKMLKAKLYQK 297
Cdd:COG1186    20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2136273316 298 KLEEQQAE-LDEIRGEQKEIGWGSQIRsyvfhpySLVKDHRTNTEVGN 344
Cdd:COG1186   100 ELEPKERRaTKPTRGSKKRRLWGKQIR-------SMVKDLRGNVDDGD 140
PCRF smart00937
This domain is found in peptide chain release factors;
84-194 5.86e-52

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 168.41  E-value: 5.86e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316   84 ELLKEEYDEDLHEELESEV----KGLIQEMNEYELQLLLS-DPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKR 158
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELeeleAELEEELEELLKLLLLPkDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2136273316  159 GFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAE 194
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 129-305 1.08e-27

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 107.55  E-value: 1.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 129 LELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAG-IKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFD 207
Cdd:TIGR03072   3 LQLSSAQGPAECCLAVAKALERLTREAAARGVRVEVLEQEPGEVPGtLRSALVSLDGEAAAALADRWEGTLLWICPSPYR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 208 SSGRRHTSFV---SCEVVPEFNDEveievrteDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQiknre 284
Cdd:TIGR03072  83 PHHRRKNWFIgvqRFSASEEATED--------EIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQ----- 149

                         170       180
                  ....*....|....*....|.
gi 2136273316 285 HAMKMLKAKLYQKKLEEQQAE 305
Cdd:TIGR03072 150 HANKRLATLLLAVRLADLQQE 170
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
237-292 2.62e-08

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 52.08  E-value: 2.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2136273316 237 DLKIDTYRASGAGGQHVNTTDSAV-------------------------RIThtpTN--TVVTCQSERSQIKNREHAMKM 289
Cdd:PRK09256   14 ELEWRFIRASGPGGQNVNKVSTAVelrfdiaasslpefykerllalaghRIT---KDgvIVIKAQEFRSQERNREDALER 90


                  ...
gi 2136273316 290 LKA 292
Cdd:PRK09256   91 LVA 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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