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Conserved domains on  [gi|2147737729|gb|UES72678|]
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beta-tubulin, partial [Cadophora qinghai-tibetana]

Protein Classification

tubulin beta chain( domain architecture ID 1000126)

tubulin beta chain is part of tubulin, a dimer of alpha and beta chains, which is the major constituent of microtubules and binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain

CATH:  1.10.287.600|3.30.1330.20|3.40.50.1440
Gene Ontology:  GO:0005874|GO:0007017|GO:0005525|GO:0005200|GO:0003924
PubMed:  33800665|3896122|2194680

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00220 super family cl30499
tubulin beta chain; Provisional
 1-100 1.75e-68

tubulin beta chain; Provisional


The actual alignment was detected with superfamily member PLN00220:

Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 211.22  E-value: 1.75e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQL 80
Cdd:PLN00220    5 LHIQGGQCGNQIGAKFWEVVCDEHGIDPTGTYHGDSDLQLERINVYYNEASGGRYVPRAVLMDLEPGTMDSVRSGPYGQI 84

                          90       100
                  ....*....|....*....|
gi 2147737729  81 FRPDNFVFGQSGAGNNWAKG 100
Cdd:PLN00220   85 FRPDNFVFGQSGAGNNWAKG 104
 
Name Accession Description Interval E-value
PLN00220 PLN00220
tubulin beta chain; Provisional
 1-100 1.75e-68

tubulin beta chain; Provisional


Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 211.22  E-value: 1.75e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQL 80
Cdd:PLN00220    5 LHIQGGQCGNQIGAKFWEVVCDEHGIDPTGTYHGDSDLQLERINVYYNEASGGRYVPRAVLMDLEPGTMDSVRSGPYGQI 84

                          90       100
                  ....*....|....*....|
gi 2147737729  81 FRPDNFVFGQSGAGNNWAKG 100
Cdd:PLN00220   85 FRPDNFVFGQSGAGNNWAKG 104
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 1-100 6.46e-68

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 208.96  E-value: 6.46e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQL 80
Cdd:cd02187     4 IHIQIGQCGNQIGAKFWETISKEHGIDPDGTYKGDSDLQLERINVYFNEASGGKYVPRAVLVDLEPGTIDSVRSGPYGQL 83

                          90       100
                  ....*....|....*....|
gi 2147737729  81 FRPDNFVFGQSGAGNNWAKG 100
Cdd:cd02187    84 FRPDNFVFGQSGAGNNWAKG 103
Tubulin pfam00091
Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma ...
 1-100 3.15e-24

Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.


Pssm-ID: 459669 [Multi-domain]  Cd Length: 190  Bit Score: 90.36  E-value: 3.15e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQTISGEHGLDgsgvyngtsdlqleRLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGpfgql 80
Cdd:pfam00091   3 IVIGVGGAGNNIGNALWELLCLEHGID--------------SLNVFFSESGSVEFIPRSLAIDTDPQALNEIKAG----- 63

                          90       100
                  ....*....|....*....|
gi 2147737729  81 FRPDNFVFGQSGAGNNWAKG 100
Cdd:pfam00091  64 FNPNKILLGKEGTGGNGAGG 83
 
Name Accession Description Interval E-value
PLN00220 PLN00220
tubulin beta chain; Provisional
 1-100 1.75e-68

tubulin beta chain; Provisional


Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 211.22  E-value: 1.75e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQL 80
Cdd:PLN00220    5 LHIQGGQCGNQIGAKFWEVVCDEHGIDPTGTYHGDSDLQLERINVYYNEASGGRYVPRAVLMDLEPGTMDSVRSGPYGQI 84

                          90       100
                  ....*....|....*....|
gi 2147737729  81 FRPDNFVFGQSGAGNNWAKG 100
Cdd:PLN00220   85 FRPDNFVFGQSGAGNNWAKG 104
PTZ00010 PTZ00010
tubulin beta chain; Provisional
 1-100 1.94e-68

tubulin beta chain; Provisional


Pssm-ID: 240228 [Multi-domain]  Cd Length: 445  Bit Score: 211.17  E-value: 1.94e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQL 80
Cdd:PTZ00010    5 VHIQAGQCGNQIGSKFWEVISDEHGIDPTGTYQGDSDLQLERINVYYNEATGGRYVPRAVLMDLEPGTMDSVRAGPYGQL 84

                          90       100
                  ....*....|....*....|
gi 2147737729  81 FRPDNFVFGQSGAGNNWAKG 100
Cdd:PTZ00010   85 FRPDNFIFGQSGAGNNWAKG 104
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 1-100 6.46e-68

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 208.96  E-value: 6.46e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQL 80
Cdd:cd02187     4 IHIQIGQCGNQIGAKFWETISKEHGIDPDGTYKGDSDLQLERINVYFNEASGGKYVPRAVLVDLEPGTIDSVRSGPYGQL 83

                          90       100
                  ....*....|....*....|
gi 2147737729  81 FRPDNFVFGQSGAGNNWAKG 100
Cdd:cd02187    84 FRPDNFVFGQSGAGNNWAKG 103
gamma_tubulin cd02188
The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of ...
 3-100 1.69e-36

The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping.


Pssm-ID: 276957 [Multi-domain]  Cd Length: 430  Bit Score: 127.27  E-value: 1.69e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   3 LQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFR 82
Cdd:cd02188     6 LQVGQCGNQIGSEFWKQLCSEHGISPDGSLEDFATDGNDRKDVFFYQADDEHYIPRAILLDLEPRVINSIQNSPYKNLFN 85

                          90       100
                  ....*....|....*....|
gi 2147737729  83 PDNFVFGQ--SGAGNNWAKG 100
Cdd:cd02188    86 PENIYLSKegGGAGNNWASG 105
alpha_tubulin cd02186
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 1-100 6.15e-30

The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276955 [Multi-domain]  Cd Length: 434  Bit Score: 109.94  E-value: 6.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLqtGQCGNQIGAAFWQTISGEHGL--DGSGVYNGTSDLQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFG 78
Cdd:cd02186     6 IHV--GQAGVQIGNACWELFCLEHGIqpDGQMPSDKTIGGDDDNFNTFFSETGSGKYVPRAVFVDLEPTVIDEIRTGPYR 83

                          90       100
                  ....*....|....*....|..
gi 2147737729  79 QLFRPDNFVFGQSGAGNNWAKG 100
Cdd:cd02186    84 QLFHPEQLISGKEDAANNFARG 105
PLN00222 PLN00222
tubulin gamma chain; Provisional
 1-100 4.43e-28

tubulin gamma chain; Provisional


Pssm-ID: 215108 [Multi-domain]  Cd Length: 454  Bit Score: 105.31  E-value: 4.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQL 80
Cdd:PLN00222    6 ITLQVGQCGNQIGMEFWKQLCLEHGISKDGILEDFATQGGDRKDVFFYQADDEHYIPRALLIDLEPRVINGIQNSEYRNL 85

                          90       100
                  ....*....|....*....|..
gi 2147737729  81 FRPDNFVFGQS--GAGNNWAKG 100
Cdd:PLN00222   86 YNHENIFVSDHggGAGNNWASG 107
delta_zeta_tubulin-like cd02189
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ...
 1-100 1.70e-26

The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.


Pssm-ID: 276958 [Multi-domain]  Cd Length: 433  Bit Score: 100.42  E-value: 1.70e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQTISGEhgLDGSgvynGTSDLQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQL 80
Cdd:cd02189     3 VTVQVGQCGNQLGDELFDTLADE--ADSS----ASEGDQNSSATRFFSPFSDGKLKARCVLVDMEPKVVQQVLSRARSGA 76

                          90       100
                  ....*....|....*....|..
gi 2147737729  81 --FRPDNFVFGQSGAGNNWAKG 100
Cdd:cd02189    77 wsYDPKNVVCGQSGSGNNWALG 98
Tubulin cd06059
The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct ...
 1-100 4.40e-25

The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Also included in this group is the mitochondrial Misato/DML1 protein family, involved in mitochondrial fusion and in mitochondrial distribution and morphology.


Pssm-ID: 276963 [Multi-domain]  Cd Length: 387  Bit Score: 96.12  E-value: 4.40e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQTIsgehgldgsgvyngtsdlqlerlnvyfneasgnkyvpRAVLVDLEPGTMDAVRAGPFGQL 80
Cdd:cd06059     3 ITIQVGQCGNQIGDRFWELA-------------------------------------RAVLVDMEEGVINEVLKGPLGQL 45

                          90       100
                  ....*....|....*....|
gi 2147737729  81 FRPDNFVFGQSGAGNNWAKG 100
Cdd:cd06059    46 FDPNQFVTGVSGAGNNWAVG 65
Tubulin pfam00091
Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma ...
 1-100 3.15e-24

Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.


Pssm-ID: 459669 [Multi-domain]  Cd Length: 190  Bit Score: 90.36  E-value: 3.15e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQTISGEHGLDgsgvyngtsdlqleRLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGpfgql 80
Cdd:pfam00091   3 IVIGVGGAGNNIGNALWELLCLEHGID--------------SLNVFFSESGSVEFIPRSLAIDTDPQALNEIKAG----- 63

                          90       100
                  ....*....|....*....|
gi 2147737729  81 FRPDNFVFGQSGAGNNWAKG 100
Cdd:pfam00091  64 FNPNKILLGKEGTGGNGAGG 83
PTZ00335 PTZ00335
tubulin alpha chain; Provisional
 3-100 1.33e-23

tubulin alpha chain; Provisional


Pssm-ID: 185562 [Multi-domain]  Cd Length: 448  Bit Score: 92.85  E-value: 1.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   3 LQTGQCGNQIGAAFWQTISGEHGL--DGSGVYNGTSDLQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQL 80
Cdd:PTZ00335    7 IHIGQAGIQVGNACWELFCLEHGIqpDGQMPSDKNIGVEDDAFNTFFSETGAGKHVPRCVFLDLEPTVIDEVRTGTYRQL 86

                          90       100
                  ....*....|....*....|
gi 2147737729  81 FRPDNFVFGQSGAGNNWAKG 100
Cdd:PTZ00335   87 FHPEQLISGKEDAANNFARG 106
epsilon_tubulin cd02190
The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the ...
 3-100 2.73e-23

The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not ubiquitous among eukaryotes play a role in basal body/centriole morphogenesis.


Pssm-ID: 276959 [Multi-domain]  Cd Length: 449  Bit Score: 91.92  E-value: 2.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   3 LQTGQCGNQIGAAFWQTISGEHG-LDGSGVYNGTSDLQLERLNVYFNEASGNKYVP------RAVLVDLEPGTMDAVRAG 75
Cdd:cd02190     6 VQVGQCGNQIGCRFWDLALREHAaYNKDGVYDDSMSSFFRNVDTRSGDPGDDGGSPikslkaRAVLIDMEEGVVNELLKG 85

                          90       100
                  ....*....|....*....|....*
gi 2147737729  76 PFGQLFRPDNFVFGQSGAGNNWAKG 100
Cdd:cd02190    86 PLGDLFDETQLVTDVSGAGNNWAHG 110
PLN00221 PLN00221
tubulin alpha chain; Provisional
 1-100 3.15e-23

tubulin alpha chain; Provisional


Pssm-ID: 177802  Cd Length: 450  Bit Score: 91.79  E-value: 3.15e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQTISGEHGL--DGSGVYNGTSDLQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFG 78
Cdd:PLN00221    5 ISIHIGQAGIQVGNACWELYCLEHGIqpDGQMPSDKTVGGGDDAFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYR 84

                          90       100
                  ....*....|....*....|..
gi 2147737729  79 QLFRPDNFVFGQSGAGNNWAKG 100
Cdd:PLN00221   85 QLFHPEQLISGKEDAANNFARG 106
PTZ00387 PTZ00387
epsilon tubulin; Provisional
 1-100 9.03e-22

epsilon tubulin; Provisional


Pssm-ID: 240395 [Multi-domain]  Cd Length: 465  Bit Score: 87.86  E-value: 9.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQTISGEH-GLDGSGVYNGTSDLQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQ 79
Cdd:PTZ00387    5 VTVQVGQCGNQLGHRFWDVALKEHkKINANPQYDDARDSFFENVSENVNRPGKENLKARAVLVDMEEGVLNQILKSPLGD 84

                          90       100
                  ....*....|....*....|.
gi 2147737729  80 LFRPDNFVFGQSGAGNNWAKG 100
Cdd:PTZ00387   85 LFDENFFVSDVSGAGNNWAVG 105
Tubulin_FtsZ_Cetz-like cd00286
Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, ...
 1-100 2.20e-18

Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, gamma-, delta-, epsilon, and zeta-tubulins as well as FtsZ and CetZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. A recent study found that CetZ proteins, formerly annotated FtsZ type 2, are not required for cell division, whereas FtsZ proteins play an important role. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development.


Pssm-ID: 276954 [Multi-domain]  Cd Length: 332  Bit Score: 77.45  E-value: 2.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2147737729   1 VHLQTGQCGNQIGAAFWQtisgehgldgsgvyngtsdlqlerlnvyfneasgnkyvpRAVLVDLEPGTMDAVRAGPFGQL 80
Cdd:cd00286     3 VTIQVGQCGNQIGAAFWE---------------------------------------QAVLVDLEPAVLDELLSGPLRQL 43

                          90       100
                  ....*....|....*....|..
gi 2147737729  81 FRPDNFVFGQS--GAGNNWAKG 100
Cdd:cd00286    44 FHPENIILIQKyhGAGNNWAKG 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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