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Conserved domains on  [gi|2161760725|gb|UGC00519|]
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VEGFA, partial [Emberiza bruniceps]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF super family cl00116
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 1-60 1.26e-24

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


The actual alignment was detected with superfamily member smart00141:

Pssm-ID: 444701  Cd Length: 83  Bit Score: 86.71  E-value: 1.26e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161760725   1 LVDIFQEYPDEVEYIFKPSCVPLMRCAGCCGDEGLECVPVDVYNVTMEIMRIKPHQSQHI 60
Cdd:smart00141  9 VVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHL 68
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 1-60 1.26e-24

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 86.71  E-value: 1.26e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161760725   1 LVDIFQEYPDEVEYIFKPSCVPLMRCAGCCGDEGLECVPVDVYNVTMEIMRIKPHQSQHI 60
Cdd:smart00141  9 VVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHL 68
PDGF pfam00341
PDGF/VEGF domain;
1-60 4.20e-23

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 82.72  E-value: 4.20e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161760725  1 LVDIFQEYPDEVEYIFKPSCVPLMRCAGCCGDEGLECVPVDVYNVTMEIMRIKPHQSQHI 60
Cdd:pfam00341  7 LVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPS 66
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 1-59 5.69e-23

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 82.42  E-value: 5.69e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 2161760725  1 LVDIFQEYPDEVEYIFKPSCVPLMRCAGCCGDEGLECVPVDVYNVTMEIMRIKPHQSQH 59
Cdd:cd00135    9 LVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKRKPR 67
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 2-50 7.64e-14

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 61.18  E-value: 7.64e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2161760725   2 VDIFQEYPDEVEYIFKPSCVPLMRCAGCCGDEGLECVPVDVYNVTMEIM 50
Cdd:PHA02661   55 VQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSNVTVTVM 103
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 1-60 1.26e-24

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 86.71  E-value: 1.26e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161760725   1 LVDIFQEYPDEVEYIFKPSCVPLMRCAGCCGDEGLECVPVDVYNVTMEIMRIKPHQSQHI 60
Cdd:smart00141  9 VVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHL 68
PDGF pfam00341
PDGF/VEGF domain;
1-60 4.20e-23

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 82.72  E-value: 4.20e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161760725  1 LVDIFQEYPDEVEYIFKPSCVPLMRCAGCCGDEGLECVPVDVYNVTMEIMRIKPHQSQHI 60
Cdd:pfam00341  7 LVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPS 66
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 1-59 5.69e-23

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 82.42  E-value: 5.69e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 2161760725  1 LVDIFQEYPDEVEYIFKPSCVPLMRCAGCCGDEGLECVPVDVYNVTMEIMRIKPHQSQH 59
Cdd:cd00135    9 LVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKRKPR 67
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 2-50 7.64e-14

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 61.18  E-value: 7.64e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2161760725   2 VDIFQEYPDEVEYIFKPSCVPLMRCAGCCGDEGLECVPVDVYNVTMEIM 50
Cdd:PHA02661   55 VQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSNVTVTVM 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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