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Conserved domains on  [gi|2178104981|gb|UIW38036|]
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truncated RAD51-like C protein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
radA super family cl35256
DNA repair and recombination protein RadA; Validated
 10-135 3.43e-12

DNA repair and recombination protein RadA; Validated


The actual alignment was detected with superfamily member PRK04301:

Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 62.20  E-value: 3.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178104981  10 MQRDLVSFP-LSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALetlQIIR--RECLTnkpryAGTSEshkkcT 86
Cdd:PRK04301    4 KEKDLEDLPgVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGESTAA---KIIEaaREAAD-----IGGFE-----T 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2178104981  87 ALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKNTIM 135
Cdd:PRK04301   71 ALEVLERRKNVGKITTGSKELDELLGGGIETQSITEFYGEFGSGKTQIC 119
 
Name Accession Description Interval E-value
radA PRK04301
DNA repair and recombination protein RadA; Validated
 10-135 3.43e-12

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 62.20  E-value: 3.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178104981  10 MQRDLVSFP-LSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALetlQIIR--RECLTnkpryAGTSEshkkcT 86
Cdd:PRK04301    4 KEKDLEDLPgVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGESTAA---KIIEaaREAAD-----IGGFE-----T 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2178104981  87 ALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKNTIM 135
Cdd:PRK04301   71 ALEVLERRKNVGKITTGSKELDELLGGGIETQSITEFYGEFGSGKTQIC 119
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 86-134 1.59e-04

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 40.36  E-value: 1.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2178104981  86 TALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKNTI 134
Cdd:pfam08423   5 TATELHQRRSELIQITTGSKELDKLLGGGIETGSITEIFGEFRTGKTQL 53
Rad51B cd19493
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 108-143 2.09e-04

RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410901 [Multi-domain]  Cd Length: 222  Bit Score: 40.00  E-value: 2.09e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2178104981 108 DDILGGGVPLMKTTEICGAPGVGKNTIMYAVGSRCA 143
Cdd:cd19493     1 DTALAGGLPLGAITEITGASGSGKTQFALTLASSAA 36
recomb_DMC1 TIGR02238
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ...
 26-131 1.36e-03

meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.


Pssm-ID: 131292 [Multi-domain]  Cd Length: 313  Bit Score: 37.84  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178104981  26 KLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECltnKPRYAgtseshkkcTALELLEQEHTQGFIITFCS 105
Cdd:TIGR02238  16 KLKSAGICTVNGVIMTTRRALCKIKGLSEAKVDKIKEAASKII---NPGFI---------TAFEISQKRKKVLKITTGSQ 83

                          90       100
                  ....*....|....*....|....*.
gi 2178104981 106 ALDDILGGGVPLMKTTEICGAPGVGK 131
Cdd:TIGR02238  84 ALDGILGGGIESMSITEVFGEFRCGK 109
 
Name Accession Description Interval E-value
radA PRK04301
DNA repair and recombination protein RadA; Validated
 10-135 3.43e-12

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 62.20  E-value: 3.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178104981  10 MQRDLVSFP-LSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALetlQIIR--RECLTnkpryAGTSEshkkcT 86
Cdd:PRK04301    4 KEKDLEDLPgVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGESTAA---KIIEaaREAAD-----IGGFE-----T 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2178104981  87 ALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKNTIM 135
Cdd:PRK04301   71 ALEVLERRKNVGKITTGSKELDELLGGGIETQSITEFYGEFGSGKTQIC 119
PTZ00035 PTZ00035
Rad51 protein; Provisional
 26-134 2.71e-05

Rad51 protein; Provisional


Pssm-ID: 185407 [Multi-domain]  Cd Length: 337  Bit Score: 42.68  E-value: 2.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178104981  26 KLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECLTNKpryagtseshkkCTALELLEQEHTQGFIITFCS 105
Cdd:PTZ00035   38 KLKEAGICTVESVAYATKKDLCNIKGISEAKVEKIKEAASKLVPMGF------------ISATEYLEARKNIIRITTGST 105

                          90       100
                  ....*....|....*....|....*....
gi 2178104981 106 ALDDILGGGVPLMKTTEICGAPGVGKNTI 134
Cdd:PTZ00035  106 QLDKLLGGGIETGSITELFGEFRTGKTQL 134
radB PRK09361
DNA repair and recombination protein RadB; Provisional
 100-134 4.21e-05

DNA repair and recombination protein RadB; Provisional


Pssm-ID: 236482 [Multi-domain]  Cd Length: 225  Bit Score: 41.77  E-value: 4.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2178104981 100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKNTI 134
Cdd:PRK09361    5 LPTGCKMLDELLGGGFERGTITQIYGPPGSGKTNI 39
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 86-134 1.59e-04

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 40.36  E-value: 1.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2178104981  86 TALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKNTI 134
Cdd:pfam08423   5 TATELHQRRSELIQITTGSKELDKLLGGGIETGSITEIFGEFRTGKTQL 53
Rad51B cd19493
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 108-143 2.09e-04

RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410901 [Multi-domain]  Cd Length: 222  Bit Score: 40.00  E-value: 2.09e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2178104981 108 DDILGGGVPLMKTTEICGAPGVGKNTIMYAVGSRCA 143
Cdd:cd19493     1 DTALAGGLPLGAITEITGASGSGKTQFALTLASSAA 36
archRadB cd01394
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional ...
 100-134 2.11e-04

archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional homologue to the bacterial RecA. The precise function of RadB is unclear.


Pssm-ID: 410882 [Multi-domain]  Cd Length: 216  Bit Score: 39.60  E-value: 2.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2178104981 100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKNTI 134
Cdd:cd01394     1 LSTGSKSLDSLLGGGVERGTITQIYGPPGSGKTNI 35
PLN03186 PLN03186
DNA repair protein RAD51 homolog; Provisional
 26-142 2.75e-04

DNA repair protein RAD51 homolog; Provisional


Pssm-ID: 178728 [Multi-domain]  Cd Length: 342  Bit Score: 39.72  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178104981  26 KLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQiirrecLTNKPRYAGTseshkkCTALELLEQEHTQGFIITFCS 105
Cdd:PLN03186   43 KLKDAGIHTVESLAYAPKKDLLQIKGISEAKVEKILE------AASKLVPLGF------TTASQLHAQRQEIIQITTGSR 110

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2178104981 106 ALDDILGGGVPLMKTTEICGAPGVGKNTIMYAVGSRC 142
Cdd:PLN03186  111 ELDKILEGGIETGSITEIYGEFRTGKTQLCHTLCVTC 147
PLN03187 PLN03187
meiotic recombination protein DMC1 homolog; Provisional
 8-147 4.38e-04

meiotic recombination protein DMC1 homolog; Provisional


Pssm-ID: 215620 [Multi-domain]  Cd Length: 344  Bit Score: 38.99  E-value: 4.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178104981   8 FEMQRDLVSFPLSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRecLTNKpryagtseshKKCTA 87
Cdd:PLN03187   28 FESIDKLISQGINAGDVKKLQDAGIYTCNGLMMHTKKNLTGIKGLSEAKVDKICEAAEK--LLNQ----------GFITG 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178104981  88 LELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKNTIMYAVgsrCADTRM 147
Cdd:PLN03187   96 SDALLKRKSVVRITTGSQALDELLGGGIETRCITEAFGEFRSGKTQLAHTL---CVTTQL 152
PRK09302 PRK09302
circadian clock protein KaiC; Reviewed
 107-131 5.43e-04

circadian clock protein KaiC; Reviewed


Pssm-ID: 236461 [Multi-domain]  Cd Length: 509  Bit Score: 39.09  E-value: 5.43e-04
                          10        20
                  ....*....|....*....|....*
gi 2178104981 107 LDDILGGGVPLMKTTEICGAPGVGK 131
Cdd:PRK09302   20 FDDITHGGLPKGRPTLVSGTAGTGK 44
XRCC3 cd19491
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ...
 107-131 8.73e-04

XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410899 [Multi-domain]  Cd Length: 250  Bit Score: 38.04  E-value: 8.73e-04
                          10        20
                  ....*....|....*....|....*
gi 2178104981 107 LDDILGGGVPLMKTTEICGAPGVGK 131
Cdd:cd19491     1 LDELLGGGIPVGGITEIAGESGAGK 25
recomb_DMC1 TIGR02238
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ...
 26-131 1.36e-03

meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.


Pssm-ID: 131292 [Multi-domain]  Cd Length: 313  Bit Score: 37.84  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178104981  26 KLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECltnKPRYAgtseshkkcTALELLEQEHTQGFIITFCS 105
Cdd:TIGR02238  16 KLKSAGICTVNGVIMTTRRALCKIKGLSEAKVDKIKEAASKII---NPGFI---------TAFEISQKRKKVLKITTGSQ 83

                          90       100
                  ....*....|....*....|....*.
gi 2178104981 106 ALDDILGGGVPLMKTTEICGAPGVGK 131
Cdd:TIGR02238  84 ALDGILGGGIESMSITEVFGEFRCGK 109
KaiC-N cd19485
N-terminal domain of Circadian Clock Protein Kaic; KaiC is a circadian clock protein, most ...
 107-131 1.89e-03

N-terminal domain of Circadian Clock Protein Kaic; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410893 [Multi-domain]  Cd Length: 226  Bit Score: 36.96  E-value: 1.89e-03
                          10        20
                  ....*....|....*....|....*
gi 2178104981 107 LDDILGGGVPLMKTTEICGAPGVGK 131
Cdd:cd19485     8 FDDITHGGLPKGRPTLICGTAGTGK 32
ATPase pfam06745
KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and ...
 107-135 2.55e-03

KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and eukaryotes. More than one copy is sometimes found in each protein. This family includes KaiC, which is one of the Kai proteins among which direct protein-protein association may be a critical process in the generation of circadian rhythms in cyanobacteria.


Pssm-ID: 429095 [Multi-domain]  Cd Length: 231  Bit Score: 36.84  E-value: 2.55e-03
                          10        20
                  ....*....|....*....|....*....
gi 2178104981 107 LDDILGGGVPLMKTTEICGAPGVGKnTIM 135
Cdd:pfam06745   8 LDEILKGGFPEGRVVLITGGPGTGK-TIF 35
PRK12377 PRK12377
putative replication protein; Provisional
 28-141 7.35e-03

putative replication protein; Provisional


Pssm-ID: 183482 [Multi-domain]  Cd Length: 248  Bit Score: 35.58  E-value: 7.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2178104981  28 VSAGFQTAEELLEVKPSElskevGISKAEALETL-QIIRRECLTNKpryAGTSESHKKCTALELLEQEHTQGFIITFCSA 106
Cdd:PRK12377   21 VQPPFRTVDEWREWQLAE-----GRKRSEEINRQnQQLRVEKILNR---SGIQPLHRKCSFANYQVQNDGQRYALSQAKS 92

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2178104981 107 LDDILGGGVPLMKTTeicGAPGVGKNTIMYAVGSR 141
Cdd:PRK12377   93 IADELMTGCTNFVFS---GKPGTGKNHLAAAIGNR 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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