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Conserved domains on  [gi|2197668443|gb|ULI14952|]
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protein-tyrosine-phosphatase Etp (plasmid) [Klebsiella pneumoniae]

Protein Classification

protein-tyrosine-phosphatase Etp( domain architecture ID 10793568)

protein-tyrosine-phosphatase Etp dephosphorylates etk

CATH:  3.40.50.2300
EC:  3.1.3.48
Gene Ontology:  GO:0035335|GO:0004725
SCOP:  4000436

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 5-148 8.67e-108

phosphotyrosine-protein phosphatase; Provisional


:

Pssm-ID: 138553  Cd Length: 144  Bit Score: 302.71  E-value: 8.67e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443   5 KFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDLIL 84
Cdd:PRK11391    1 KFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDLIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2197668443  85 AMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR 148
Cdd:PRK11391   81 AMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR 144
 
Name Accession Description Interval E-value
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 5-148 8.67e-108

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 302.71  E-value: 8.67e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443   5 KFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDLIL 84
Cdd:PRK11391    1 KFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDLIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2197668443  85 AMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR 148
Cdd:PRK11391   81 AMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR 144
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 7-144 2.28e-55

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 170.31  E-value: 2.28e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443   7 NSILVVCTGNICRSPIGERLLRKRLP-----GVKVKSAGVHGL-VKHPADATAADVAANHGVSLEGHAGRKLTAEMARNY 80
Cdd:cd16343     1 KKILFVCLGNICRSPMAEAVLRHLLPkaggdDVEVDSAGTSAWhGGEPPDPRARAVLKEHGIDLSGHRARQLTAEDFDEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2197668443  81 DLILAMESEHIAQVTAIAP-EVRGKTMLFGQWL--EQKEIPDPYRKSQDAFEHVYGMLERASQEWAK 144
Cdd:cd16343    81 DLILAMDESNLRDLRRLAPaEARGKVFLLGDFDpeGGKDVPDPYYGGREGFEEVYDLIERACEGLLE 147
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
9-143 1.20e-53

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 166.01  E-value: 1.20e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443   9 ILVVCTGNICRSPIGERLLRKRLPG------VKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDL 82
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKaglgdkVEVDSAGTGAWPGNPADPRAVEVLKEHGIDLSGHYARQLSTEDFASFDL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2197668443  83 ILAMESEHIAQVTAIAPE-VRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWA 143
Cdd:pfam01451  81 ILAMDSEHKRDLCPLAPErYRAKVMLLGEYGEQLDIPDPYYGSIDAFEEVRDLIERRCRQLL 142
LMWPc smart00226
Low molecular weight phosphatase family;
9-144 5.36e-46

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 146.08  E-value: 5.36e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443    9 ILVVCTGNICRSPIGERLLRKRLP-GVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAgRKLTAEMARNYDLILAME 87
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGdRVKIDSAGTGAWVGGGADPRAVKVLKEHGIDLSHHA-SQLTSSDFKNADLVLAMD 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2197668443   88 SEHIAQVTAIAPEVRGKTMLFGQWleqKEIPDPYRKSQDAFEHVYGMLERASQEWAK 144
Cdd:smart00226  80 GSHLRNICRLKPPSRAKVELFGHY---VDVDDPYYGGIDGFERVYDELENALQEFLK 133
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
5-148 4.55e-42

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 136.45  E-value: 4.55e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443   5 KFNSILVVCTGNICRSPIGERLLRKRLPG-VKVKSAGVHGlvKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDLI 83
Cdd:COG0394     2 MPKRVLFVCTGNICRSPMAEALLRHLAGGrVEVDSAGTEP--GGPVDPRAVAVLAERGIDLSGHRSRQLDEEDLPEFDLV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2197668443  84 LAMESEHIAQVTAIAPevrGKTMLFGQWleqkEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR 148
Cdd:COG0394    80 ITMCDSAAEELCPLFP---GAAKLLLHW----DVPDPYYGGLEAFREVRDEIERRIEALLAKLRR 137
arsC_pI258_fam TIGR02691
arsenate reductase (thioredoxin); This family describes the well-studied thioredoxin-dependent ...
 9-44 1.21e-03

arsenate reductase (thioredoxin); This family describes the well-studied thioredoxin-dependent arsenate reductase of Staphylococcus aureaus plasmid pI258 and other mechanistically similar arsenate reductases. The mechanism involves an intramolecular disulfide bond cascade, and aligned members of this family have four absolutely conserved Cys residues. This group of arsenate reductases belongs to the low-molecular weight protein-tyrosine phosphatase family (pfam01451), as does a group of glutathione/glutaredoxin type arsenate reductases (TIGR02689). At least two other, non-homologous groups of arsenate reductases involved in arsenical resistance are also known. This enzyme reduces arsenate to arsenite, which may be more toxic but which is more easily exported. [Cellular processes, Detoxification]


Pssm-ID: 131738  Cd Length: 129  Bit Score: 36.68  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2197668443   9 ILVVCTGNICRSPIGERLLRKRL-PGVKVKSAGV--HGL 44
Cdd:TIGR02691   1 IYFLCTGNSCRSQMAEGWGKKYLgDEWEVYSAGIeaHGL 39
 
Name Accession Description Interval E-value
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 5-148 8.67e-108

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 302.71  E-value: 8.67e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443   5 KFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDLIL 84
Cdd:PRK11391    1 KFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDLIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2197668443  85 AMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR 148
Cdd:PRK11391   81 AMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR 144
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
6-146 2.46e-60

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 183.19  E-value: 2.46e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443   6 FNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDLILA 85
Cdd:PRK10126    2 FNNILVVCVGNICRSPTAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLILT 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2197668443  86 MESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRL 146
Cdd:PRK10126   82 MEKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYRKSREAFEAVYTLLERSARQWAQAL 142
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 7-144 2.28e-55

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 170.31  E-value: 2.28e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443   7 NSILVVCTGNICRSPIGERLLRKRLP-----GVKVKSAGVHGL-VKHPADATAADVAANHGVSLEGHAGRKLTAEMARNY 80
Cdd:cd16343     1 KKILFVCLGNICRSPMAEAVLRHLLPkaggdDVEVDSAGTSAWhGGEPPDPRARAVLKEHGIDLSGHRARQLTAEDFDEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2197668443  81 DLILAMESEHIAQVTAIAP-EVRGKTMLFGQWL--EQKEIPDPYRKSQDAFEHVYGMLERASQEWAK 144
Cdd:cd16343    81 DLILAMDESNLRDLRRLAPaEARGKVFLLGDFDpeGGKDVPDPYYGGREGFEEVYDLIERACEGLLE 147
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
9-143 1.20e-53

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 166.01  E-value: 1.20e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443   9 ILVVCTGNICRSPIGERLLRKRLPG------VKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDL 82
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKaglgdkVEVDSAGTGAWPGNPADPRAVEVLKEHGIDLSGHYARQLSTEDFASFDL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2197668443  83 ILAMESEHIAQVTAIAPE-VRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWA 143
Cdd:pfam01451  81 ILAMDSEHKRDLCPLAPErYRAKVMLLGEYGEQLDIPDPYYGSIDAFEEVRDLIERRCRQLL 142
LMWP cd00115
Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group ...
 8-144 1.58e-46

Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group of small soluble enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). This family includes protein tyrosine phosphatases, arginine phosphatases and arsenate reductases.


Pssm-ID: 319970  Cd Length: 137  Bit Score: 147.64  E-value: 1.58e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443   8 SILVVCTGNICRSPIGERLLRKRL-PGVKVKSAGVHGLVKHPADATAADVAANHGVSLEgHAGRKLTAEMARNYDLILAM 86
Cdd:cd00115     1 SILFICTGNICRSPMAEAIFKQLLgDEWKVDSAGTGAHHGEGADPRAVRVLKEVGIDIS-HRSDQIKSEHLDNYDLVLVM 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2197668443  87 ESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAK 144
Cdd:cd00115    80 DGSNLDKIPRIFPEARGKTWLPHVKLEHGEIDDPYRGDIEDFRRVRDELENASKRFAE 137
LMWPc smart00226
Low molecular weight phosphatase family;
9-144 5.36e-46

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 146.08  E-value: 5.36e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443    9 ILVVCTGNICRSPIGERLLRKRLP-GVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAgRKLTAEMARNYDLILAME 87
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGdRVKIDSAGTGAWVGGGADPRAVKVLKEHGIDLSHHA-SQLTSSDFKNADLVLAMD 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2197668443   88 SEHIAQVTAIAPEVRGKTMLFGQWleqKEIPDPYRKSQDAFEHVYGMLERASQEWAK 144
Cdd:smart00226  80 GSHLRNICRLKPPSRAKVELFGHY---VDVDDPYYGGIDGFERVYDELENALQEFLK 133
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
5-148 4.55e-42

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 136.45  E-value: 4.55e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443   5 KFNSILVVCTGNICRSPIGERLLRKRLPG-VKVKSAGVHGlvKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDLI 83
Cdd:COG0394     2 MPKRVLFVCTGNICRSPMAEALLRHLAGGrVEVDSAGTEP--GGPVDPRAVAVLAERGIDLSGHRSRQLDEEDLPEFDLV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2197668443  84 LAMESEHIAQVTAIAPevrGKTMLFGQWleqkEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR 148
Cdd:COG0394    80 ITMCDSAAEELCPLFP---GAAKLLLHW----DVPDPYYGGLEAFREVRDEIERRIEALLAKLRR 137
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 9-138 4.04e-28

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 100.97  E-value: 4.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2197668443   9 ILVVCTGNICRSPIGERLLRKRLP--GVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDLILAM 86
Cdd:cd16344     3 ILFVCTGNTCRSPMAEAILKKLLEelDVEVKSAGIFAVDGSPASPNAVEVLKEKGIDLSGHRSQQLTEELLEWADLILTM 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2197668443  87 ESEHIAQVTAIAPEVRGKTMLFGQW--LEQKEIPDPYRKSQDAFEHVYGMLERA 138
Cdd:cd16344    83 TESHKQALLSLYPEAADKVFTLKEYvgGEDGDISDPFGGSLEVYRQTAEELEEL 136
LMWP_ArsC cd16345
Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the ...
 9-42 1.36e-07

Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).


Pssm-ID: 319973  Cd Length: 132  Bit Score: 47.44  E-value: 1.36e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2197668443   9 ILVVCTGNICRSPIGERLLRKRLPG-VKVKSAGVH 42
Cdd:cd16345     2 VLFLCTGNSARSQMAEALLRHLGGDrFEAYSAGSE 36
arsC_pI258_fam TIGR02691
arsenate reductase (thioredoxin); This family describes the well-studied thioredoxin-dependent ...
 9-44 1.21e-03

arsenate reductase (thioredoxin); This family describes the well-studied thioredoxin-dependent arsenate reductase of Staphylococcus aureaus plasmid pI258 and other mechanistically similar arsenate reductases. The mechanism involves an intramolecular disulfide bond cascade, and aligned members of this family have four absolutely conserved Cys residues. This group of arsenate reductases belongs to the low-molecular weight protein-tyrosine phosphatase family (pfam01451), as does a group of glutathione/glutaredoxin type arsenate reductases (TIGR02689). At least two other, non-homologous groups of arsenate reductases involved in arsenical resistance are also known. This enzyme reduces arsenate to arsenite, which may be more toxic but which is more easily exported. [Cellular processes, Detoxification]


Pssm-ID: 131738  Cd Length: 129  Bit Score: 36.68  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2197668443   9 ILVVCTGNICRSPIGERLLRKRL-PGVKVKSAGV--HGL 44
Cdd:TIGR02691   1 IYFLCTGNSCRSQMAEGWGKKYLgDEWEVYSAGIeaHGL 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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