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Conserved domains on  [gi|2252308982|gb|URQ63005|]
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adenylosuccinate synthase [SAR86 cluster bacterium]

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10011626)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  3.40.440.10|3.90.170.10|1.10.300.10
EC:  6.3.4.4
Gene Ontology:  GO:0044208|GO:0004019|GO:0005525|GO:0003688|GO:0000287
PubMed:  8244965|11916378|6347525|10218106
SCOP:  4003995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 4-420 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


:

Pssm-ID: 439874  Cd Length: 423  Bit Score: 648.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   4 SLILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLEE 83
Cdd:COG0104     1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  84 VETIESKGINLEGKLRISRYCSLLLPIHAKIDQLRED--NKNKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLK 161
Cdd:COG0104    81 IDGLEARGVDVRSRLRISERAHLILPYHRALDKAREEarGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPEVLREKLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 162 NLLDYYNFQIENIHRAEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSSN 241
Cdd:COG0104   161 ELLEYKNFLLEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 242 TLATSVGVGSGF-PKSIyADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKL 320
Cdd:COG0104   241 TTAGGACTGSGVgPTKI-DRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRI 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 321 NNLTSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQY---KSRQLHKVKPKYKIFKGWEQSLGQCQNYSELPKEAREFLEFI 397
Cdd:COG0104   320 NGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEfpaSLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERI 399

                         410       420
                  ....*....|....*....|...
gi 2252308982 398 EDYTKVKISLISNGPQRNDLIHR 420
Cdd:COG0104   400 EELLGVPISIVSVGPDREQTIVR 422
 
Name Accession Description Interval E-value
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 4-420 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 648.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   4 SLILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLEE 83
Cdd:COG0104     1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  84 VETIESKGINLEGKLRISRYCSLLLPIHAKIDQLRED--NKNKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLK 161
Cdd:COG0104    81 IDGLEARGVDVRSRLRISERAHLILPYHRALDKAREEarGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPEVLREKLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 162 NLLDYYNFQIENIHRAEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSSN 241
Cdd:COG0104   161 ELLEYKNFLLEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 242 TLATSVGVGSGF-PKSIyADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKL 320
Cdd:COG0104   241 TTAGGACTGSGVgPTKI-DRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRI 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 321 NNLTSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQY---KSRQLHKVKPKYKIFKGWEQSLGQCQNYSELPKEAREFLEFI 397
Cdd:COG0104   320 NGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEfpaSLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERI 399

                         410       420
                  ....*....|....*....|...
gi 2252308982 398 EDYTKVKISLISNGPQRNDLIHR 420
Cdd:COG0104   400 EELLGVPISIVSVGPDREQTIVR 422
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-418 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 646.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   1 MKNsLILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSL 80
Cdd:PRK01117    1 MKN-VVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  81 LEEVETIESKGINLEGKLRISRYCSLLLPIHAKIDQLREDNK--NKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLED 158
Cdd:PRK01117   80 LKEIDELEARGVDVRERLRISERAHLILPYHRALDKAREKARgkKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 159 KLKNLLDYYNFQIENIHRAEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVT 238
Cdd:PRK01117  160 KLEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 239 SSNTLATSVGVGSGF-PKSIyADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYS 317
Cdd:PRK01117  240 SSNTTAGGAATGSGVgPTKI-DYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 318 AKLNNLTSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQY---KSRQLHKVKPKYKIFKGWEQSLGQCQNYSELPKEAREFL 394
Cdd:PRK01117  319 VRVNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYfpaSLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYI 398

                         410       420
                  ....*....|....*....|....
gi 2252308982 395 EFIEDYTKVKISLISNGPQRNDLI 418
Cdd:PRK01117  399 KRIEELTGVPISIISTGPDRDQTI 422
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
6-418 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 641.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   6 ILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLEEVE 85
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  86 TIESKGINLEGKLRISRYCSLLLPIHAKIDQLREDNK--NKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLKNL 163
Cdd:pfam00709  81 ELEERGIDVPDRLFISDRAHLILPYHKALDGLREEARgkKKIGTTGRGIGPAYSDKAARRGIRVGDLLDPEVFREKLEAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 164 LDYYNFQIENIHRaEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSSNTL 243
Cdd:pfam00709 161 LELKNKLLEKLYG-EPLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNTT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 244 ATSVGVGSGF-PKSIyADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKLNN 322
Cdd:pfam00709 240 AGGACTGLGIgPTKI-DEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRING 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 323 LTSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQY---KSRQLHKVKPKYKIFKGWEQSLGQCQNYSELPKEAREFLEFIED 399
Cdd:pfam00709 319 VTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYfpaDLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEE 398

                         410
                  ....*....|....*....
gi 2252308982 400 YTKVKISLISNGPQRNDLI 418
Cdd:pfam00709 399 LLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 4-419 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 617.19  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982    4 SLILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLEE 83
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   84 VETIESKGINLEGKLRISRYCSLLLPIHAKIDQLREdnKNKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLKNL 163
Cdd:smart00788  81 IEELEAKGVDVKDRLFISDRAHLILPYHIALDKARE--KARIGTTGRGIGPAYEDKVARRGIRVGDLFDEEVLREKLEEL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  164 LDYYNFQIENIHRAEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSSNTL 243
Cdd:smart00788 159 LDYKNFLLKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSNTT 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  244 ATSVGVGSGF-PKSIyADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKLNN 322
Cdd:smart00788 239 AGGAATGAGIgPTRI-DRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRING 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  323 LTSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQY---KSRQLHKVKPKYKIFKGWEQSLGQCQNYSELPKEAREFLEFIED 399
Cdd:smart00788 318 ITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYfpaDLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIEE 397

                          410       420
                   ....*....|....*....|
gi 2252308982  400 YTKVKISLISNGPQRNDLIH 419
Cdd:smart00788 398 LVGVPVSIISTGPDREQTIV 417
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 6-418 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 513.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   6 ILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLEEVE 85
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  86 TIESKGINLEGKLRISRYCSLLLPIHAKIDQLREDNK--NKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLKNL 163
Cdd:TIGR00184  81 YLEKRGISVRDRLFVSYRCHLILPYHKKLDKAREKSKlaKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEAFAEKAKNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 164 LDYYNFQIENIHRAEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSSNTL 243
Cdd:TIGR00184 161 LEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSNTT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 244 ATSVGVGSGFPKSIYADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKLNNL 323
Cdd:TIGR00184 241 AGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 324 TSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQY---KSRQLHKVKPKYKIFKGWEQSLGQCQNYSELPKEAREFLEFIEDY 400
Cdd:TIGR00184 321 TQLALTKLDVLDGIDEIKVCVAYRMKGEILELfplDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEEL 400

                         410
                  ....*....|....*...
gi 2252308982 401 TKVKISLISNGPQRNDLI 418
Cdd:TIGR00184 401 TGVPVTIISTGPEREQTI 418
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 3-419 8.07e-165

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 465.44  E-value: 8.07e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   3 NSLILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLE 82
Cdd:cd03108     1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  83 EVETIESKGINLEGKLRISRYCSLLLPIHAKIDQLREDNK--NKIGTTRRGIGPAYEDKTARRSIKAFDleddslledkl 160
Cdd:cd03108    81 EIEELEKKGIDVKGRLLISDRAHLVFPYHQELDGLEEKERggKKIGTTKRGIGPAYADKAARTGIRVGD----------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 161 knlldyynfqienihraekfsyqevfdnlketysktsKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSS 240
Cdd:cd03108   150 -------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSS 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 241 NTLATSVGVGSGFPKSIYADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKL 320
Cdd:cd03108   193 NTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRI 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 321 NNLTSLCVTKLDVldsfseikvcdeyeidnevvqyksrqlhkvkpkykifkgweqslgqcqnyselpkEAREFLEFIEDY 400
Cdd:cd03108   273 NGLTELALTKLDV-------------------------------------------------------NAQKYIERIEEL 297

                         410
                  ....*....|....*....
gi 2252308982 401 TKVKISLISNGPQRNDLIH 419
Cdd:cd03108   298 LGVPITYISVGPDREQTII 316
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
6-307 8.89e-26

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 105.91  E-value: 8.89e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   6 ILVGTQWGDEGKGKIVDYFSEKFSAVCRFQ-GGHNAGHTIYNDE-KKFVLHLIPSGIFY-DHVSCFIGQGVILSLDSLLE 82
Cdd:NF038379    3 VVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTYIDDEgRKFVHRMLPNGIVSpPLKQVLIGPGSEIDLEVLRE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  83 EVETIESKGINLEGKLRISRYCSlLLPIHAKIDQlREDNKNKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLKN 162
Cdd:NF038379   83 EIEELEDAGHDVGKRLLIHEQAT-VIELHKHVEE-EAGPMTKIGSTKKGIGAARAAKIRRNPSTLGDAEGDFGEGAVRDQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 163 LLDYynfqienihraekfsyqEVFDNLKETYsktskffGDVTDSLEeiyekgnHILYEGAQGTLLDVDYGTYPYVTSSNT 242
Cdd:NF038379  161 PWEI-----------------AERVVDNALY-------DFALQAAE-------RIQIEGTQGYSLGLHAGFYPYCTSRDC 209

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2252308982 243 LATSVGVGSGFPKSI--YADVLGVVKAYTTRVGEGPFPTeLHDENGEKIAKIG--NEFGATTGRPRRCG 307
Cdd:NF038379  210 TPADFLADAGIPLPNvdAFKVVGTARTYPIRVAGWSGNS-YPDQGETTWEELGlpEELTTVTKKVRRVG 277
 
Name Accession Description Interval E-value
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 4-420 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 648.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   4 SLILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLEE 83
Cdd:COG0104     1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  84 VETIESKGINLEGKLRISRYCSLLLPIHAKIDQLRED--NKNKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLK 161
Cdd:COG0104    81 IDGLEARGVDVRSRLRISERAHLILPYHRALDKAREEarGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPEVLREKLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 162 NLLDYYNFQIENIHRAEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSSN 241
Cdd:COG0104   161 ELLEYKNFLLEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 242 TLATSVGVGSGF-PKSIyADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKL 320
Cdd:COG0104   241 TTAGGACTGSGVgPTKI-DRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRI 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 321 NNLTSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQY---KSRQLHKVKPKYKIFKGWEQSLGQCQNYSELPKEAREFLEFI 397
Cdd:COG0104   320 NGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEfpaSLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERI 399

                         410       420
                  ....*....|....*....|...
gi 2252308982 398 EDYTKVKISLISNGPQRNDLIHR 420
Cdd:COG0104   400 EELLGVPISIVSVGPDREQTIVR 422
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-418 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 646.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   1 MKNsLILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSL 80
Cdd:PRK01117    1 MKN-VVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  81 LEEVETIESKGINLEGKLRISRYCSLLLPIHAKIDQLREDNK--NKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLED 158
Cdd:PRK01117   80 LKEIDELEARGVDVRERLRISERAHLILPYHRALDKAREKARgkKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 159 KLKNLLDYYNFQIENIHRAEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVT 238
Cdd:PRK01117  160 KLEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 239 SSNTLATSVGVGSGF-PKSIyADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYS 317
Cdd:PRK01117  240 SSNTTAGGAATGSGVgPTKI-DYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 318 AKLNNLTSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQY---KSRQLHKVKPKYKIFKGWEQSLGQCQNYSELPKEAREFL 394
Cdd:PRK01117  319 VRVNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYfpaSLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYI 398

                         410       420
                  ....*....|....*....|....
gi 2252308982 395 EFIEDYTKVKISLISNGPQRNDLI 418
Cdd:PRK01117  399 KRIEELTGVPISIISTGPDRDQTI 422
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
6-418 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 641.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   6 ILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLEEVE 85
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  86 TIESKGINLEGKLRISRYCSLLLPIHAKIDQLREDNK--NKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLKNL 163
Cdd:pfam00709  81 ELEERGIDVPDRLFISDRAHLILPYHKALDGLREEARgkKKIGTTGRGIGPAYSDKAARRGIRVGDLLDPEVFREKLEAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 164 LDYYNFQIENIHRaEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSSNTL 243
Cdd:pfam00709 161 LELKNKLLEKLYG-EPLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNTT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 244 ATSVGVGSGF-PKSIyADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKLNN 322
Cdd:pfam00709 240 AGGACTGLGIgPTKI-DEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRING 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 323 LTSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQY---KSRQLHKVKPKYKIFKGWEQSLGQCQNYSELPKEAREFLEFIED 399
Cdd:pfam00709 319 VTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYfpaDLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEE 398

                         410
                  ....*....|....*....
gi 2252308982 400 YTKVKISLISNGPQRNDLI 418
Cdd:pfam00709 399 LLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 4-419 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 617.19  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982    4 SLILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLEE 83
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   84 VETIESKGINLEGKLRISRYCSLLLPIHAKIDQLREdnKNKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLKNL 163
Cdd:smart00788  81 IEELEAKGVDVKDRLFISDRAHLILPYHIALDKARE--KARIGTTGRGIGPAYEDKVARRGIRVGDLFDEEVLREKLEEL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  164 LDYYNFQIENIHRAEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSSNTL 243
Cdd:smart00788 159 LDYKNFLLKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSNTT 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  244 ATSVGVGSGF-PKSIyADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKLNN 322
Cdd:smart00788 239 AGGAATGAGIgPTRI-DRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRING 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  323 LTSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQY---KSRQLHKVKPKYKIFKGWEQSLGQCQNYSELPKEAREFLEFIED 399
Cdd:smart00788 318 ITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYfpaDLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIEE 397

                          410       420
                   ....*....|....*....|
gi 2252308982  400 YTKVKISLISNGPQRNDLIH 419
Cdd:smart00788 398 LVGVPVSIISTGPDREQTIV 417
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 6-418 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 513.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   6 ILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLEEVE 85
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  86 TIESKGINLEGKLRISRYCSLLLPIHAKIDQLREDNK--NKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLKNL 163
Cdd:TIGR00184  81 YLEKRGISVRDRLFVSYRCHLILPYHKKLDKAREKSKlaKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEAFAEKAKNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 164 LDYYNFQIENIHRAEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSSNTL 243
Cdd:TIGR00184 161 LEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSNTT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 244 ATSVGVGSGFPKSIYADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKLNNL 323
Cdd:TIGR00184 241 AGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 324 TSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQY---KSRQLHKVKPKYKIFKGWEQSLGQCQNYSELPKEAREFLEFIEDY 400
Cdd:TIGR00184 321 TQLALTKLDVLDGIDEIKVCVAYRMKGEILELfplDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEEL 400

                         410
                  ....*....|....*...
gi 2252308982 401 TKVKISLISNGPQRNDLI 418
Cdd:TIGR00184 401 TGVPVTIISTGPEREQTI 418
PLN02513 PLN02513
adenylosuccinate synthase
 1-420 3.35e-167

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 475.67  E-value: 3.35e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   1 MKNSLILvGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDE-KKFVLHLIPSGIFYDHVSCFIGQGVILSLDS 79
Cdd:PLN02513    2 SQVSAVL-GTQWGDEGKGKLVDILAQHFDIVARCQGGANAGHTIYNDEgKKFALHLVPSGILNEKTTCVIGNGVVVHLPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  80 LLEEVETIESKGINLEGKLRISRYCSLLLPIHAKIDQLREDN--KNKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLE 157
Cdd:PLN02513   81 LFEEIDGLESNGVSCEGRLLVSDRAHLLFDFHQEVDGLREAElaGSKIGTTKRGIGPAYSSKATRNGLRVGDLRHMDTFA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 158 DKLKNLLDYYNFqienihRAEKFSY-QEVFDNLKETYSKTSK----FFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYG 232
Cdd:PLN02513  161 EKLRELLADAAA------RFEGFEYdASMVEEEVEAYKKFAErlepFITDTVHYLNEAIQAGKKILVEGAQATMLDIDFG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 233 TYPYVTSSNTLATSVGVGSGFPKSIYADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLV 312
Cdd:PLN02513  235 TYPFVTSSNPSAGGICTGLGIAPRKLGDIIGVVKAYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIV 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 313 ALKYSAKLNNLTSLCVTKLDVLDSFSEIKVCDEYE-IDNEVVQY---KSRQLHKVKPKYKIFKGWEQSLGQCQNYSELPK 388
Cdd:PLN02513  315 ALKYSCQINGFTSLNLTKLDVLSGLPEIKIGVAYKtPDGKVVKSfpaDLDTLEQVEVVYEVLPGWQEDISSVRNYDDLPA 394

                         410       420       430
                  ....*....|....*....|....*....|..
gi 2252308982 389 EAREFLEFIEDYTKVKISLISNGPQRNDLIHR 420
Cdd:PLN02513  395 AAQAYVERIEELVGVPVHYIGVGPGRDALIVK 426
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 3-419 8.07e-165

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 465.44  E-value: 8.07e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   3 NSLILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLE 82
Cdd:cd03108     1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  83 EVETIESKGINLEGKLRISRYCSLLLPIHAKIDQLREDNK--NKIGTTRRGIGPAYEDKTARRSIKAFDleddslledkl 160
Cdd:cd03108    81 EIEELEKKGIDVKGRLLISDRAHLVFPYHQELDGLEEKERggKKIGTTKRGIGPAYADKAARTGIRVGD----------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 161 knlldyynfqienihraekfsyqevfdnlketysktsKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSS 240
Cdd:cd03108   150 -------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSS 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 241 NTLATSVGVGSGFPKSIYADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKL 320
Cdd:cd03108   193 NTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRI 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 321 NNLTSLCVTKLDVldsfseikvcdeyeidnevvqyksrqlhkvkpkykifkgweqslgqcqnyselpkEAREFLEFIEDY 400
Cdd:cd03108   273 NGLTELALTKLDV-------------------------------------------------------NAQKYIERIEEL 297

                         410
                  ....*....|....*....
gi 2252308982 401 TKVKISLISNGPQRNDLIH 419
Cdd:cd03108   298 LGVPITYISVGPDREQTII 316
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 1-420 2.71e-161

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 461.03  E-value: 2.71e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   1 MKNSLILV-GTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDS 79
Cdd:PTZ00350   10 LKSKVVVIlGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  80 LLEEVETIESKGINLEGKLRISRYCSLLLPIHAKIDQLREDNKNK----IGTTRRGIGPAYEDKTARRSIKAFDLED--- 152
Cdd:PTZ00350   90 LLEEIEQLTKKGINLLGRLYISDRAHLVFDLHQAIDGIQESEKGKggtqIGTTKRGIGPCYSTKASRTGLRVGDLLNfet 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 153 -DSLLEDKLKNLLDYYNFQIENIhraekfsyQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDY 231
Cdd:PTZ00350  170 fEKKYRKLVEKLQEQYNIEEYDA--------EEELERYKGYAEKLKDMIVDTVYFMNKAIKEGKRVLVEGANATMLDIDF 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 232 GTYPYVTSSNTLATSVGVGSGFPKSIYADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDL 311
Cdd:PTZ00350  242 GTYPYVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 312 VALKYSAKLNNLTSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQ-----YKSRQLHKVKPKYKIFKGWEQSLGQCQNYSEL 386
Cdd:PTZ00350  322 PALRYVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGTGLEigrypSSIEELEEYEPVYETMPGWKTDISKCKTFEEL 401

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2252308982 387 PKEAREFLEFIEDYTKVKISLISNGPQRNDLIHR 420
Cdd:PTZ00350  402 PENAQKYVLFIEELLGVPIVWIGVGPNRENMIVK 435
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 3-418 5.00e-146

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 421.05  E-value: 5.00e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   3 NSLILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLE 82
Cdd:PRK13783    1 MKRVIVGLQWGDEGKGKVVTYLSRYYDIVVRYSGGANAGHTVNYGDFKVVHHLLPSADFKKNVGAAIGNGVVLDLEVLVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  83 EVETIESKGINLEGKLRISRYCSLLLPIHAKIDQLRED-NKNKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLK 161
Cdd:PRK13783   81 ELEELKEKFPDYSGRIFISELAHVVLPVHKELDEIIESvRKNAIGTTKRGIGPAYADKVMRVGVRLADLFDEEKLREFLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 162 NLLDYYNfqieNIHRAEkFSYQEVFDNLKETYSKTSKFfgdVTDSLEEIYE-KGNHILYEGAQGTLLDVDYGTYPYVTSS 240
Cdd:PRK13783  161 KILSLYK----KLYGIE-FDVEKMMEDLLTFYEKIKDL---VVSPVEIKRIlEEKSVLFEGTQGVLLDLDVGTYPYVTSS 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 241 NTLATSVGVGSGFPKSIyADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKL 320
Cdd:PRK13783  233 NCSTTGVSAGMGFPVKV-DEVIGVFKAYTTRVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYAIEV 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 321 NNLTSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQ--YKSRQLHKVKPKYKIFKGWEqslgqcqnySELPKEAREFLEFIE 398
Cdd:PRK13783  312 SGVDSLVMTKADVLNGFEKIKVCVRYEIGGKEVRdpSSLRDLEKAEPVYEEFDGWK---------SLEDKNFLKFVDFIE 382

                         410       420
                  ....*....|....*....|
gi 2252308982 399 DYTKVKISLISNGPQRNDLI 418
Cdd:PRK13783  383 RETGRKIAYISTGPKIEEIV 402
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 1-418 7.36e-133

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 388.54  E-value: 7.36e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   1 MKNSLIlVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSL 80
Cdd:PRK13787    1 MPASLV-VGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLDPLFF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  81 LEEVETIESKGINLEGKLRISRYCSLLLPIHAKIDQLRE---DNKNKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLlE 157
Cdd:PRK13787   80 IEECDRLQKEGFPVKDKLLLSDACHLLFPYHSQIDSAREttsSQEHKIGTTKKGIGICYADKMMRTGLRVGDLLDKSY-K 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 158 DKLKNLLDYYNFQIENIHRAEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYV 237
Cdd:PRK13787  159 RRLKHLVDEKNRELDKLYGMPPVSYNDINDGLKFFLSKVGKNIINTAYYLDTELKKGKRVLLEGAQGTGLDVDFGTYPYV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 238 TSSNTLATSVGVGSGFPKSIYADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYS 317
Cdd:PRK13787  239 TSSNPTTGGALIGTGISFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDVEMLKHS 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 318 AKLNNLTSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQ-YKSRQLHKVKPKYKIFKGWEQSLGQCQNYSELPKEAREFLEF 396
Cdd:PRK13787  319 VRINGITSIALTKIDILSDYDTIPVAVGYKLNGKTLDcFPSQGLEKVEPLYEEFPGWKDDISGINEFQKLPEKCKNYISA 398

                         410       420
                  ....*....|....*....|..
gi 2252308982 397 IEDYTKVKISLISNGPQRNDLI 418
Cdd:PRK13787  399 LEKWIGVKINLVSTGPDRKDTI 420
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 6-414 6.19e-123

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 362.97  E-value: 6.19e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   6 ILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDhVSCFIGQGVILSLDSLLEEVE 85
Cdd:PRK13786    4 IITGAQFGDEGKGKIVDLLAKDYDIVARFQGGDNAGHTVKVGDEVYKLHLIPSGFLLD-ARVLIGPGVVLNPEVLAEEID 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  86 TIESKGINLEG-KLRISRYCSLLLPIHAKIDQLRED-NKNKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLKNL 163
Cdd:PRK13786   83 MLEKHGVKVDAeKLGIDAKTSIIMPYHIELDGLRESaRTEKIGTTKRGIGFAYIDKIARDEVRMSDLVDKERLMRRLEEL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 164 LDYYNFQIENIHRAEKF-SYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSSNT 242
Cdd:PRK13786  163 APQKEKEIKELGGDPSIvRDEALIDKYLELGRQLAPYITDVSYEINKALDEGKSVLAEGAQGTHLDVIHGTQKFVTSSST 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 243 LATSVGVGSGFPKSIYADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKLNN 322
Cdd:PRK13786  243 IAGSACANLGVGPTRVDNVLGIVKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGWFDLPLLKKAIYLNG 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 323 LTSLCVTKLDVLDSFSEIKVCDEYEIDNEVVQYK---SRQLHKVKPKYKIFKGWEQSLGQCQNYSELPKEAREFLEFIED 399
Cdd:PRK13786  323 YTEIALTKLDVLTGLDPIKICVGYELDGEILDYPpelTSDLARCVPVYEELEGWSTDLTEVKAYEDLPENARNYVERLEE 402

                         410
                  ....*....|....*
gi 2252308982 400 YTKVKISLISNGPQR 414
Cdd:PRK13786  403 LMGVPIKYISVGPGR 417
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 7-416 3.22e-120

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 355.27  E-value: 3.22e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   7 LVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLEEVET 86
Cdd:PRK13788    6 IIGAQWGDEGKGKVVDALAPEADFVVRYQGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVIDPFRFAEEREN 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  87 IESKGinLEGKLRISRYCSLLLPIHAKIDQlredNKNKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLKNLLDY 166
Cdd:PRK13788   86 LRAGG--LNPKLLISERAHLVLPHHKYVDG----RKNFVGTTGRGIGPAYSDRARRVGIRFGDLLDEAVLRERVERLLEA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 167 ynfQIENIHRAEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSSNTLATS 246
Cdd:PRK13788  160 ---KPNSTREAGWDTVEKALADLAPMREILLPFIADTGSLLREAIREGKRVLFEGAQATLLDLNYGTYPYVTSSHPTVGG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 247 VGVGSGFPKSIYADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIG----NEFGATTGRPRRCGWLDLVALKYSAKLNN 322
Cdd:PRK13788  237 ILVGAGVNHKAINKVYGVAKAFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVLLKYACEVNG 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 323 LTSLCVTKLDVLDSFSEIKVCDEYEIDNevvqyksrqlhkvKPKYKIFKGWEQSLGqCQNYSELPKEAREFLEFIEDYTK 402
Cdd:PRK13788  317 FDGLVLTKLDVLSGLEKVKVCVEYDDDG-------------QPVYKELPGWGDLDG-VKSREALPKEAQAYLELIEETTG 382

                         410
                  ....*....|....
gi 2252308982 403 VKISLISNGPQRND 416
Cdd:PRK13788  383 VPVVMFSTSPRRED 396
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
 3-418 1.18e-105

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 319.27  E-value: 1.18e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   3 NSLILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLLE 82
Cdd:PRK13784    2 SNIVIVGAQWGDEGKGKIADTLAEKADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALDE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  83 EVETIESKGINLEGK-LRISRYCSLLLPIHAKIDQLREDNKN-KIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKL 160
Cdd:PRK13784   82 EITRLQAKGIAISAEnLFVSESCTIITSYHKLLDAVRESNTSeKIGTTGKGIGPAYEDKVSRKGIKFKHLFDKDLLRSRL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 161 KNLLDYYNFQIENIHRAEKFSYQEVFDNLKETYSKTSKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSS 240
Cdd:PRK13784  162 AISLAEKETLFRDLYKVEYPTLEQEFDKLFALGQKLKQYAADTFSIIDQAIAAGKNVVYEGAQGVLLDVDYGTYPFVTSS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 241 NTLATSVGVGSGFPKSIYADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIGNEFGATTGRPRRCGWLDLVALKYSAKL 320
Cdd:PRK13784  242 NTSVAGVYSGATTAGHGLDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLDLPLLKYSAKC 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 321 NNLTSLCVTKLDVLDSFSEIKVCDEYEIDNEVV--QYKSRQLHKVKPKYKIFKGWeqSLGQCQNYSELPKEAREFLEFIE 398
Cdd:PRK13784  322 SNLTSIALTKVDVLSDMDTLKVCIGYKYEGKEIycAYPGIDLYKVEPILVEMEPF--SIDETVTKDNMPAALKTYLKTIE 399

                         410       420
                  ....*....|....*....|
gi 2252308982 399 DYTKVKISLISNGPQRNDLI 418
Cdd:PRK13784  400 NHVGIPISSLAYGPSREQIL 419
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 4-420 4.53e-105

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 318.24  E-value: 4.53e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   4 SLILVGTQWGDEGKGKIVDYFSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVsCFIGQGVILSLDSLLEE 83
Cdd:PRK13785    2 TVTIVGSQLGDEGKGGVVDLYGDAADVVVRYQGGDNAGHTVVHGGEEYKLSLVPSGAVRGKI-GVLGNGCVVNPETLFDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  84 VETIESKGinLEGKLRISRYCSLLLPIHAKIDQLREDNKNK----IGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDK 159
Cdd:PRK13785   81 IDALRERG--LDPDVRVAERAHVILPYHRVLDGIEEEAKSDsdleVGTTGRGIGPTYEDKAGRRGVRVGDLLDPDVLRDR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 160 LKNLLDYYNFQIENIHRAEKFSYQEVFD--NLKETYSKTSKFFGD------VTDSLEEIYEKGNHILYEGAQGTLLDVDY 231
Cdd:PRK13785  159 LEYVVPQKRALAEDVYGLDASETPEAFDvdALFEEYREYGERLAEedmtvnAGDFLAERIDDGDNVMLEGAQGTSIDIDH 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 232 GTYPYVTSSNTLATSVGVGSGFPKSIYAD--VLGVVKAYTTRVGEGPFPTEL---------------HDENGEKIAKIGN 294
Cdd:PRK13785  239 GNYPYVTSSNPTAGGAATGTGLGPTVVGQgeVVGIVKAYLSRVGSGPLPTELggvegdtpdeggrpdEEELATYIREEGG 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 295 EFGATTGRPRRCGWLDLVALKYSAKLNNLTSLCVTKLDVLDSFSEIKVCDEYEIDNE---VVQYKSRQLHKVKPKYKIFK 371
Cdd:PRK13785  319 EYGTVTGRPRRVGWLDMPMLRHAARASGFTGLAINHIDVLAGLDEVKVGHSYELDGEellTMPATTERWARCEPNFRSFD 398

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2252308982 372 GWEQ---SLGQCQNYSELPKEAREFLEFIEDYTKVKISLISNGPQRNDLIHR 420
Cdd:PRK13785  399 GWPEvdwAAVAEEGYDALPENARTYLEYVSDELDTPIYAVGVGPGREETVVL 450
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
 4-418 9.77e-82

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 254.42  E-value: 9.77e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   4 SLILVGTQWGDEGKGKIVDY--FSEKFSAVCRFQGGHNAGHTIYNDEKKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLL 81
Cdd:PRK04293    3 CTIVVGGFFGDEGKGKIIAYlaLKDKPSIIARGGVGPNAGHTVEYNGKKYGLRMIPSGFVNKDAKLAIGAGVLVDPEVLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  82 EEVETIESKGinlegKLRISRYCSLLLPIHAKIDQLREDNKNKIGTTRRGIGPAYEDKTARRSIKAFDleddslledklk 161
Cdd:PRK04293   83 KEVEELNVGG-----RVFVDYRCGIIEEKHVEEDRSDEHLSKKIGSTGTGCGPANADRVLRRLKLAKD------------ 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 162 nlldyynfqienihraekfsyqevFDNLKetysktsKFFGDVTDSLEEIYEKGNHILYEGAQGTLLDVDYGTYPYVTSSN 241
Cdd:PRK04293  146 ------------------------VEELE-------KYLTDVPEEVNEALDRGENVLIEGTQGFGLSLYYGTYPYVTSKD 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 242 TLATS----VGVGsgfPKSIyADVLGVVKAYTTRVGEGPFPTELHDENGEKIAKIgnEFGATTGRPRRCGWLDLVALKYS 317
Cdd:PRK04293  195 TTASGiasdVGVG---PTKV-DEVIVVFKSYPTRVGEGPFPTELSLEEAEKLGLV--EYGTVTGRRRRVGPFDFELARRA 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 318 AKLNNLTSLCVTKLDVLDsfseiKVCdeyeidnevvqyksrqlhkvkpkykifKGweqslgqCQNYSELPKEAREFLEFI 397
Cdd:PRK04293  269 ARINGATQIAITKLDKLD-----KEA---------------------------YG-------VTEYDKLPPEAKKFIEEI 309

                         410       420
                  ....*....|....*....|.
gi 2252308982 398 EDYTKVKISLISNGPQRNDLI 418
Cdd:PRK04293  310 EEELGVPVTLISTGPELEDTI 330
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
6-307 8.89e-26

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 105.91  E-value: 8.89e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   6 ILVGTQWGDEGKGKIVDYFSEKFSAVCRFQ-GGHNAGHTIYNDE-KKFVLHLIPSGIFY-DHVSCFIGQGVILSLDSLLE 82
Cdd:NF038379    3 VVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTYIDDEgRKFVHRMLPNGIVSpPLKQVLIGPGSEIDLEVLRE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  83 EVETIESKGINLEGKLRISRYCSlLLPIHAKIDQlREDNKNKIGTTRRGIGPAYEDKTARRSIKAFDLEDDSLLEDKLKN 162
Cdd:NF038379   83 EIEELEDAGHDVGKRLLIHEQAT-VIELHKHVEE-EAGPMTKIGSTKKGIGAARAAKIRRNPSTLGDAEGDFGEGAVRDQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 163 LLDYynfqienihraekfsyqEVFDNLKETYsktskffGDVTDSLEeiyekgnHILYEGAQGTLLDVDYGTYPYVTSSNT 242
Cdd:NF038379  161 PWEI-----------------AERVVDNALY-------DFALQAAE-------RIQIEGTQGYSLGLHAGFYPYCTSRDC 209

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2252308982 243 LATSVGVGSGFPKSI--YADVLGVVKAYTTRVGEGPFPTeLHDENGEKIAKIG--NEFGATTGRPRRCG 307
Cdd:NF038379  210 TPADFLADAGIPLPNvdAFKVVGTARTYPIRVAGWSGNS-YPDQGETTWEELGlpEELTTVTKKVRRVG 277
PTZ00351 PTZ00351
adenylosuccinate synthetase; Provisional
 5-419 2.61e-21

adenylosuccinate synthetase; Provisional


Pssm-ID: 173544  Cd Length: 710  Bit Score: 96.27  E-value: 2.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982   5 LILVGTQWGDEGKGKIVDYFSEKFSAVC--RFQGGHNAGHTIYNDE-KKFVLHLIPSGIFYDHVSCFIGQGVILSLDSLL 81
Cdd:PTZ00351  172 IMVAGAFFGDEGKGKTVDAVAHHPLCTCiaRVNSGENAGHTVYDKAgRKFVFNLAPSGLLLPGKRNYIGPECVMDPVSFM 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982  82 E-EVETIESKGINLEGKLRISRYCsLLLPIHAKIDQLREDNKNkigTTRRGIGPAYEDKTARRSIKAFDL-EDDSLLEDK 159
Cdd:PTZ00351  252 EkEIIQLIDAGIDYRDRLFIGNVC-IVTPYHKLLDLLGSAANS---STLKGMAPVHGSKVMKRGIRLDHIfNDDETLRKR 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 160 LKNLLDYY--NFQIENIHRAEKF---------------SYQEVFDNLKETYSKTSKFFG-------------DVTDSLEE 209
Cdd:PTZ00351  328 LEKDMDTYlgLLKVKNLSDADVVrlcreensdgvvrvpDYVIAFAQAKDKVEFLVKLYRdrvrhnpdfparcDVTYELHA 407

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 210 IYEKGNHILYEGAQGTLL-DVDYGTYPYVTSSNTLATSVGVGSGFP-KSIYADVLGVVKAY-TTRVGEG----------- 275
Cdd:PTZ00351  408 AVLRGEKVLLEGPQSYWLsNARTKFWESTTSADTTAAGLLAASQLNfQKFKSVVLNVHKAPgSSRVGIGacpssfvpqdy 487

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 276 --------------------------------PF------------PTELHDENGE---------KIAKIGNEFGATTGR 302
Cdd:PTZ00351  488 fsaqniktlrdlpsatcanfeavqrtlfrdgfPHsndkarhngimaPVEYSDETGDynigvamaiASAQHHGECGAVTKK 567

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252308982 303 PRRCGWLDLVaLKYSAKLNNLTSLCVTKLDVLDSFSEIKVCDEY--------EIDNEVVQYKS-------------RQLH 361
Cdd:PTZ00351  568 PRVCGFFDCV-LQHEVNSIQGPYLTISALDRGDEYDKVGVTIAYvyynpegkQVDVNGHVYKNgdiiragdpvpsePALY 646

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2252308982 362 KVKPKYKIFKGWEQ---SLGQCQNYSELPKEAREFLEFIEDYTKVKISLISNGPQRNDLIH 419
Cdd:PTZ00351  647 HCHPIVKLIDGWRDnpiAAAKRRRNAPLPRGVCELLSTIEYFTNCKILSIGNGPNGDDIIY 707
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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