|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
2-454 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 515.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 2 IALTLSDIANIVEGT-QSGGEVQIQEVTTDTRAIQSGALFIALVGERFDAHDFCQQAADKGAAALIVERQLDIDIPQVIV 80
Cdd:COG0770 1 ILLTLAEIAEATGGRlIGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPADLPLIVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 81 ADSKVALGLLGAEVHRRCGTKTLAITGSCGKTTVKEMVASILSGLGQVLYTAGNFNNDIGVPLTLLRSTPQDDFSVIELG 160
Cdd:COG0770 81 DDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEMG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 161 ANHIGEIAYTTALVKPDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQGESIWSEVLQDKnLITFS 240
Cdd:COG0770 161 MNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKAR-VLTFG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 241 kQNTNADFYGSDIAMSSEGyPLFTLHTPIGNVELQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSKVKRRVDV 320
Cdd:COG0770 240 -LSEDADVRAEDIELDEDG-TRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 321 EKLTEHITLIDDSYNASVPAMKAAVDLLAQFKQ-GQRWLILGNMAELGHESLALHKEVGQHAAPFAFEHVLTYGEDAKVI 399
Cdd:COG0770 318 IEGAGGVTLIDDSYNANPDSMKAALDVLAQLPGgGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELARAI 397
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 2252828254 400 SDLCG---GMHFQSHDSMLEYIERNLtqlnQTSHTLLVKGALSAGMYTIANALKETYT 454
Cdd:COG0770 398 AEAAGgerAEHFEDKEELLAALKALL----RPGDVVLVKGSRGMGLERVVEALKEGAA 451
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
1-454 |
9.00e-176 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 499.94 E-value: 9.00e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 1 MIALTLSDIANIVEGTQSGGEVQIQEVTTDTRAIQSGALFIALVGERFDAHDFCQQAADKGAAALIVERQLDIDIPQVIV 80
Cdd:PRK10773 1 MISVTLSQLADILNGELQGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDIDLPQLVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 81 ADSKVALGLLGAEVHRRCGTKTLAITGSCGKTTVKEMVASILSGLGQVLYTAGNFNNDIGVPLTLLRSTPQDDFSVIELG 160
Cdd:PRK10773 81 KDTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 161 ANHIGEIAYTTALVKPDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQGESIWSEVLQDKNLITFS 240
Cdd:PRK10773 161 ANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSVIGSKTVWRFS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 241 KQNTN-ADFYGSDIAMSSEGYPlFTLHTPIGNVELQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSKVKRRVD 319
Cdd:PRK10773 241 PNAANsVDFTATNIHVTSHGTE-FTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 320 VEKLTEHITLIDDSYNASVPAMKAAVDLLAQFKqGQRWLILGNMAELGHESLALHKEVGQHAAPFAFEHVLTYGEDAKVI 399
Cdd:PRK10773 320 PIQLAEGQLLLDDSYNANVGSMTAAAQVLAEMP-GYRVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLSVGKLSHAI 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 2252828254 400 SDLCG-GMHFQSHDSMleyIERNLTQLNQTSH-TLLVKGALSAGMYTIANALKETYT 454
Cdd:PRK10773 399 SEASGvGEHFADKTAL---IARLKALLAEHQViTILVKGSRSAAMEEVVRALQENGT 452
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
29-449 |
3.79e-163 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 466.36 E-value: 3.79e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 29 TDTRAIQSGALFIALVGERFDAHDFCQQAADKGAAALIVERQLDID--IPQVIVADSKVALGLLGAEVHRRCGTKTLAIT 106
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDngLPQILVDDTLEALQALARAKRAKFSGKVIGIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 107 GSCGKTTVKEMVASILSGLGQVLYTAGNFNNDIGVPLTLLRSTPQDDFSVIELGANHIGEIAYTTALVKPDIAMVNNVAE 186
Cdd:TIGR01143 81 GSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 187 AHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQGESIWSEVLQDKNLITFSKQntNADFYGSDIAMSSEGYPLFTLH 266
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFE--GGDFVAKDISYSALGSTSFTLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 267 TPIGNVELQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSKVKRRVDVeKLTEHITLIDDSYNASVPAMKAAVD 346
Cdd:TIGR01143 239 APGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEV-QTKNGLTLIDDTYNANPDSMRAALD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 347 LLAQFKqGQRWLILGNMAELGHESLALHKEVGQHAAPFAFEHVLTYGEDAKVISDL--CGGMHFQSHDSMLEYiernLTQ 424
Cdd:TIGR01143 318 ALARFP-GKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSfgKQGKHFADKDELLAF----LKT 392
|
410 420
....*....|....*....|....*
gi 2252828254 425 LNQTSHTLLVKGALSAGMYTIANAL 449
Cdd:TIGR01143 393 LVRKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
105-282 |
2.43e-43 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 151.30 E-value: 2.43e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 105 ITGSCGKTTVKEMVASILSGLGQVLYTAG--------NFNNDIGVPLTLLRSTPQD-DFSVIELGANHIGEiAYTTALVK 175
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVEAGaEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 176 PDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQGESIWSEVLQDKN--LITFSKqNTNADFYGSDI 253
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAGvrVITYGI-EGEADLRAANI 158
|
170 180
....*....|....*....|....*....
gi 2252828254 254 AMSSEGYPLFTLHTPIGNVELQLSLLGEH 282
Cdd:pfam08245 159 ELSSDGTSFDLFTVPGGELEIEIPLLGRH 187
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
86-214 |
6.58e-03 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 38.85 E-value: 6.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 86 ALGLLGAEVHRRCGTKTLAITGSCGKTTVKEMVASILSGLGQVLYT-AGNFNNDIGVPLTLLRSTPQddfSVIElganhI 164
Cdd:NF033197 78 AVGEILKKKYGRIPKKFIEITGVKGKTTTAELLAHILSDEYVLLHTsRGTERYPEGELSNKGSITPA---SILN-----A 149
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2252828254 165 GEIAYTTALVKPDIAmvnnVAEAHLEGFGSLD-GVKTAKGEIYqgLTANGT 214
Cdd:NF033197 150 LELAEEIGIDDYGFL----IFEVSLGGTGAGDvGIITNILEDY--PIAGGK 194
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
2-454 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 515.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 2 IALTLSDIANIVEGT-QSGGEVQIQEVTTDTRAIQSGALFIALVGERFDAHDFCQQAADKGAAALIVERQLDIDIPQVIV 80
Cdd:COG0770 1 ILLTLAEIAEATGGRlIGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPADLPLIVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 81 ADSKVALGLLGAEVHRRCGTKTLAITGSCGKTTVKEMVASILSGLGQVLYTAGNFNNDIGVPLTLLRSTPQDDFSVIELG 160
Cdd:COG0770 81 DDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEMG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 161 ANHIGEIAYTTALVKPDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQGESIWSEVLQDKnLITFS 240
Cdd:COG0770 161 MNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKAR-VLTFG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 241 kQNTNADFYGSDIAMSSEGyPLFTLHTPIGNVELQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSKVKRRVDV 320
Cdd:COG0770 240 -LSEDADVRAEDIELDEDG-TRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 321 EKLTEHITLIDDSYNASVPAMKAAVDLLAQFKQ-GQRWLILGNMAELGHESLALHKEVGQHAAPFAFEHVLTYGEDAKVI 399
Cdd:COG0770 318 IEGAGGVTLIDDSYNANPDSMKAALDVLAQLPGgGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELARAI 397
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 2252828254 400 SDLCG---GMHFQSHDSMLEYIERNLtqlnQTSHTLLVKGALSAGMYTIANALKETYT 454
Cdd:COG0770 398 AEAAGgerAEHFEDKEELLAALKALL----RPGDVVLVKGSRGMGLERVVEALKEGAA 451
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
1-454 |
9.00e-176 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 499.94 E-value: 9.00e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 1 MIALTLSDIANIVEGTQSGGEVQIQEVTTDTRAIQSGALFIALVGERFDAHDFCQQAADKGAAALIVERQLDIDIPQVIV 80
Cdd:PRK10773 1 MISVTLSQLADILNGELQGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDIDLPQLVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 81 ADSKVALGLLGAEVHRRCGTKTLAITGSCGKTTVKEMVASILSGLGQVLYTAGNFNNDIGVPLTLLRSTPQDDFSVIELG 160
Cdd:PRK10773 81 KDTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 161 ANHIGEIAYTTALVKPDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQGESIWSEVLQDKNLITFS 240
Cdd:PRK10773 161 ANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSVIGSKTVWRFS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 241 KQNTN-ADFYGSDIAMSSEGYPlFTLHTPIGNVELQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSKVKRRVD 319
Cdd:PRK10773 241 PNAANsVDFTATNIHVTSHGTE-FTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 320 VEKLTEHITLIDDSYNASVPAMKAAVDLLAQFKqGQRWLILGNMAELGHESLALHKEVGQHAAPFAFEHVLTYGEDAKVI 399
Cdd:PRK10773 320 PIQLAEGQLLLDDSYNANVGSMTAAAQVLAEMP-GYRVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLSVGKLSHAI 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 2252828254 400 SDLCG-GMHFQSHDSMleyIERNLTQLNQTSH-TLLVKGALSAGMYTIANALKETYT 454
Cdd:PRK10773 399 SEASGvGEHFADKTAL---IARLKALLAEHQViTILVKGSRSAAMEEVVRALQENGT 452
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
29-449 |
3.79e-163 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 466.36 E-value: 3.79e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 29 TDTRAIQSGALFIALVGERFDAHDFCQQAADKGAAALIVERQLDID--IPQVIVADSKVALGLLGAEVHRRCGTKTLAIT 106
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDngLPQILVDDTLEALQALARAKRAKFSGKVIGIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 107 GSCGKTTVKEMVASILSGLGQVLYTAGNFNNDIGVPLTLLRSTPQDDFSVIELGANHIGEIAYTTALVKPDIAMVNNVAE 186
Cdd:TIGR01143 81 GSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 187 AHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQGESIWSEVLQDKNLITFSKQntNADFYGSDIAMSSEGYPLFTLH 266
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFE--GGDFVAKDISYSALGSTSFTLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 267 TPIGNVELQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSKVKRRVDVeKLTEHITLIDDSYNASVPAMKAAVD 346
Cdd:TIGR01143 239 APGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEV-QTKNGLTLIDDTYNANPDSMRAALD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 347 LLAQFKqGQRWLILGNMAELGHESLALHKEVGQHAAPFAFEHVLTYGEDAKVISDL--CGGMHFQSHDSMLEYiernLTQ 424
Cdd:TIGR01143 318 ALARFP-GKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSfgKQGKHFADKDELLAF----LKT 392
|
410 420
....*....|....*....|....*
gi 2252828254 425 LNQTSHTLLVKGALSAGMYTIANAL 449
Cdd:TIGR01143 393 LVRKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
3-450 |
4.56e-124 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 383.29 E-value: 4.56e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 3 ALTLSDIANIVEGTQSGGE---VQIQEVTTDTRAIQSGALFIALVGERFDAHDFCQQAADKGAAALIVERQL-DIDIPQV 78
Cdd:PRK11929 502 SSTLIKLRAAKGGSNSLQInslPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVaDVDLPQI 581
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 79 IVADSKVALGLLGAEVHRRCGTKTLAITGSCGKTTVKEMVASILS---GLGQVLYTAGNFNNDIGVPLTLLRSTPQDDFS 155
Cdd:PRK11929 582 VVDDTRAALGRLATAWRARFSLPVVAITGSNGKTTTKEMIAAILAawqGEDRVLATEGNFNNEIGVPLTLLRLRAQHRAA 661
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 156 VIELGANHIGEIAYTTALVKPDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQGESIWSEVLQDKN 235
Cdd:PRK11929 662 VFELGMNHPGEIAYLAAIAAPTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARR 741
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 236 LITFSKQ---NTNADFYGSDIAMSSEGYPLFTLHTPIGNVELQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLS 312
Cdd:PRK11929 742 VLRFGLQpgaDVYAEKIAKDISVGEAGGTRCQVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQ 821
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 313 KVKRRVDVEKLTEHITLIDDSYNASVPAMKAAVDLLAQFKQGQRWLILGNMAELGHESLALHKEVGQHAAPFAFEHVLTY 392
Cdd:PRK11929 822 PVAGRMQRRRLSCGTRIIDDTYNANPDSMRAAIDVLAELPNGPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITL 901
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2252828254 393 GEDAK--VISDLCGGM-HFQSHDSMLEYIeRNLTQLNQtshTLLVKGALSAGMYTIANALK 450
Cdd:PRK11929 902 GEAARdaAAAFGAGARgVCASVDEIIAAL-RGALPEGD---SVLIKGSRFMRLERVVDALS 958
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
5-453 |
2.93e-54 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 188.06 E-value: 2.93e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 5 TLSDIANIVEGTQSGGEVQ-IQEVTTDTRAIQSGALFIALVGERFDAHDFCQQAADKGAAALIVER----QLDIDIPQVI 79
Cdd:PRK14093 8 TSDAMAEAMGATRSGALPRdVTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERaqrdKFAADAPLLV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 80 VADSKVALGLLGAEVHRRCGTKTLAITGSCGKTTVKEMVASILSGLGQVLYTAGNFNNDIGVPLTLLRSTPQDDFSVIEL 159
Cdd:PRK14093 88 VDDVLAALRDLGRAARARLEAKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAVFEI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 160 GANHIGEIAYTTALVKPDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLD-SQGESIWS--EVLQDKNL 236
Cdd:PRK14093 168 GMNHAGEIEPLVKMVRPHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDnPQFDRLAAsaRAAGIARI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 237 ITFSkQNTNADFYGSDIAMSSEGYplfTLHTPIG--NVELQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSK- 313
Cdd:PRK14093 248 VSFG-ADEKADARLLDVALHADCS---AVHADILghDVTYKLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPa 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 314 ----VKRRVDVEKLTEhiTLIDDSYNASVPAMKAAVDLLAQFK---QGQRWLILGNMAELGHESLALHKEVGQHAAPFAF 386
Cdd:PRK14093 324 agrgVRHTLEVGGGEA--TLIDESYNANPASMAAALGVLGRAPvgpQGRRIAVLGDMLELGPRGPELHRGLAEAIRANAI 401
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2252828254 387 EHVLTYGEDAKVISDLC-----GGmhFQSHDSMLeyiERNLTQLNQTSHTLLVKGALSAGMYTIANALKETY 453
Cdd:PRK14093 402 DLVFCCGPLMRNLWDALssgkrGG--YAEDAAAL---ESQVVAAIRAGDVIMVKGSLGSRMKTIVTALEKRF 468
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
2-437 |
1.74e-45 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 168.98 E-value: 1.74e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 2 IALTLSDIANIVE-GTQSGGEVQIQEVTTDTRAIQ--SGALFIALVGERFDAHDFCQQAADKGAA-ALIVERQLDI---- 73
Cdd:PRK11930 1 MSYTLESISGILGaEGLGDKDAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVRnFVVSEEKHPEesyp 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 74 DIPQVIVADSKVALGLLgAEVHRR-CGTKTLAITGSCGKTTVKEMVASILSGLGQVLYTAGNFNNDIGVPLTLLRSTPQD 152
Cdd:PRK11930 81 DANFLKVKDPLKALQEL-AAYHRSqFDIPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEEH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 153 DFSVIELGANHIGEIAYTTALVKPDIAMVNNVAEAHLEGFGSLdgvktaKGEIYQGLT-ANGTALINLDSQGESIWSEV- 230
Cdd:PRK11930 160 ELGIFEAGISQPGEMEALQKIIKPTIGILTNIGGAHQENFRSI------KQKIMEKLKlFKDCDVIIYNGDNELISSCIt 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 231 --LQDKNLITFSKQNTNADFYGSdIAMSSEGYPLFTLHTPIGNVELQLSLLGEhnvanavAASALAIQCGATL------- 301
Cdd:PRK11930 234 ksNLTLKLISWSRKDPEAPLYIP-FVEKKEDHTVISYTYKGEDFHFEIPFIDD-------ASIENLIHCIAVLlylgysa 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 302 EQIKIGLQSLSKVKRRVDVEKLTEHITLIDDSYNASVPAMKAAVDLLAQFKQGQ-RWLILGNMAELGHESLALHKEVGQH 380
Cdd:PRK11930 306 DQIQERMARLEPVAMRLEVKEGINNCTLINDSYNSDLQSLDIALDFLNRRSQSKkKTLILSDILQSGQSPEELYRKVAQL 385
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 381 AAPFAFEHVLTYGEDAKVISDLCGGM---HFQSHDSMLEYIErnltQLNQTSHTLLVKGA 437
Cdd:PRK11930 386 ISKRGIDRLIGIGEEISSEASKFEGTekeFFKTTEAFLKSFA----FLKFRNELILVKGA 441
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
105-282 |
2.43e-43 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 151.30 E-value: 2.43e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 105 ITGSCGKTTVKEMVASILSGLGQVLYTAG--------NFNNDIGVPLTLLRSTPQD-DFSVIELGANHIGEiAYTTALVK 175
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVEAGaEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 176 PDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQGESIWSEVLQDKN--LITFSKqNTNADFYGSDI 253
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAGvrVITYGI-EGEADLRAANI 158
|
170 180
....*....|....*....|....*....
gi 2252828254 254 AMSSEGYPLFTLHTPIGNVELQLSLLGEH 282
Cdd:pfam08245 159 ELSSDGTSFDLFTVPGGELEIEIPLLGRH 187
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
27-361 |
3.35e-38 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 144.07 E-value: 3.35e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 27 VTTDTRAIQSGALFIALVGERFDAHDFCQQAADKGAAALIVERQLDI---DIPQVIVADSKVALGLLGAEVHRRCGTK-- 101
Cdd:COG0769 2 ITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGALlaaGVPVIVVPDPRAALALLAAAFYGHPSQKlk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 102 TLAITGSCGKTTVKEMVASILSGLGQ---VLYTAGNFNNDIGVPLTLlrSTPqddfSVIEL----------GANH----- 163
Cdd:COG0769 82 LIGVTGTNGKTTTTYLLAQILRALGKktgLIGTVGNGIGGELIPSSL--TTP----EALDLqrllaemvdaGVTHvvmev 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 164 ---------IGEIAYttalvkpDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQgesiWSEVLQDK 234
Cdd:COG0769 156 sshaldqgrVDGVRF-------DVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDP----YGRRLAAA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 235 ---NLITFSKQNtNADFYGSDIAMSSEGYpLFTLHTPIGNVELQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSL 311
Cdd:COG0769 225 apaRVITYGLKA-DADLRATDIELSADGT-RFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKL 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2252828254 312 SKVKRRVDVEKLTEHITLIDDsYnASVP-AMKAAVDLLAQFKQGQRWLILG 361
Cdd:COG0769 303 KGVPGRMERVDGGQGPTVIVD-Y-AHTPdALENVLEALRPHTKGRLIVVFG 351
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
27-361 |
8.61e-30 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 120.88 E-value: 8.61e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 27 VTTDTRAIQSGALFIALVGERFDAHDFCQQAADKGAAALIVERQLDI---DIPQVIVADSKVALGLLGAEV--HRRCGTK 101
Cdd:TIGR01085 7 LTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFyvaPVPVIIVPDLRHALSSLAAAFygHPSKKLK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 102 TLAITGSCGKTTVKEMVASILSGLGQ---VLYTAGNF---NNDIGVPLTLlrSTP-----QDDFS-VIELGANHIGEIAY 169
Cdd:TIGR01085 87 VIGVTGTNGKTTTTSLIAQLLRLLGKktgLIGTIGYRlggNDLIKNPAAL--TTPealtlQSTLAeMVEAGAQYAVMEVS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 170 TTAL-------VKPDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQGESIWSEVLQDKN---LITF 239
Cdd:TIGR01085 165 SHALaqgrvrgVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQFVKRLPKDItvsAITQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 240 SKQNTNADFYGSDIAMSSEGYpLFTLHTPIGNVELQLSLLGEHNVANAVAASALAIQCG-ATLEQIKIGLQSLSKVKRRV 318
Cdd:TIGR01085 245 PADGRAQDIKITDSGYSFEGQ-QFTFETPAGEGHLHTPLIGRFNVYNLLAALATLLHLGgIDLEDIVAALEKFRGVPGRM 323
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 2252828254 319 DVEKLTEHITLIDDsYNASVPAMKAAVDLLAQFKQGQRWLILG 361
Cdd:TIGR01085 324 ELVDGGQKFLVIVD-YAHTPDALEKALRTLRKHKDGRLIVVFG 365
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
20-361 |
1.88e-24 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 105.21 E-value: 1.88e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 20 GEVQIQEVTTDTRAIQSGALFIALVGERFDAHDFCQQAADKGAAALIVERQLDI--DIPQVIVADSKVALGLLGAEVHRR 97
Cdd:PRK00139 11 APVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEAgtGVPVIIVPDLRKALALLAAAFYGH 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 98 --CGTKTLAITGSCGKTTVKEMVASILSGLGQ---VLYTAGNFNNDIGVPLTLlrSTP-----QDDFSV-IELGANHI-- 164
Cdd:PRK00139 91 psDKLKLIGVTGTNGKTTTAYLLAQILRLLGEktaLIGTLGNGIGGELIPSGL--TTPdaldlQRLLAElVDAGVTYAam 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 165 ---------GEIAYttalVKPDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLtaNGTALINLDsqgeSIWS-EVLQDK 234
Cdd:PRK00139 169 evsshaldqGRVDG----LKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSEL--GLAAVINAD----DEVGrRLLALP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 235 NLITFSKQntNADFYGSDIAMSSEGYpLFTLHTpignvELQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSKV 314
Cdd:PRK00139 239 DAYAVSMA--GADLRATDVEYTDSGQ-TFTLVT-----EVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGV 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2252828254 315 KRRVDVEKLTEHITLIDDsYnASVP-AMKAAVDLLAQFKQGQRWLILG 361
Cdd:PRK00139 311 PGRMERVDAGQGPLVIVD-Y-AHTPdALEKVLEALRPHAKGRLICVFG 356
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
18-320 |
2.11e-24 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 106.71 E-value: 2.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 18 SGGEVQIQEVTTDTRAIQSGALFIALVGERFDAHDFCQQAADKGAAALIVERQ-LDIDIP----QVIVADSKVALGLLGA 92
Cdd:PRK11929 23 RGCVAATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEgEDQVAAadalVLPVADLRKALGELAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 93 EVHRRCGTK--TLAITGSCGKTTVKEMVASILSGLGQVLYTAGNFNN-----DIGVPLT---------LLRSTPQD--DF 154
Cdd:PRK11929 103 RWYGRPSEQlsLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGArldgrLIPGSLTtpdaiilhrILARMRAAgaDA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 155 SVIElgANHIGEIAYTTALVKPDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQGESIWSEVLQDK 234
Cdd:PRK11929 183 VAME--ASSHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAAARLLAALPRG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 235 NLITFSKQNTNADFYGSDIAMSSEGYpLFTLHTPIGNVELQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSKV 314
Cdd:PRK11929 261 LKVGYSPQNAGADVQARDLRATAHGQ-VFTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPV 339
|
....*.
gi 2252828254 315 KRRVDV 320
Cdd:PRK11929 340 PGRMER 345
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
20-361 |
9.43e-19 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 88.56 E-value: 9.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 20 GEVQIQEVTTDTRAIQSGALFIAlVGERFdAHDFCQQAADKGAAALIVERQLDIDIPQVIVADSKVALGLLGAEV--HRR 97
Cdd:PRK14022 30 SGVQFDDISYDSRTADEGTLFFA-KGAYF-KHKFLQNAITQGLKLYVSEKDYEVGIPQVIVPDIKKAMSLIAMEFydNPQ 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 98 CGTKTLAITGSCGKTTVKEMVASILSGLGQ-VLYTAGN--------FNNDIGVP--LTLLRSTPQddfsVIELGANH-IG 165
Cdd:PRK14022 108 HKLKLLAFTGTKGKTTAAYFAYHILKQLHKpAMLSTMNttldgetfFKSALTTPesLDLFKMMAE----AVDNGMTHlIM 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 166 EI---AYTTALVKP---DIAMVNNVAEAHLeGF---GSLDGVKTAKGEIyqgLTANGTALINLDSQGESIWSEVLQDKNL 236
Cdd:PRK14022 184 EVssqAYLVGRVYGltfDVGVFLNITPDHI-GPiehPTFEDYFYHKRLL---MENSKAVVVNSDMDHFSELLEQVTPQEH 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 237 ITFSKQNTNAdfygsdiAMSSEGYPLFTLHTPIGNVELQlsLLGEHNVANAVAASALAIQCGATLEQIKIGLQSlSKVKR 316
Cdd:PRK14022 260 DFYGIDSENQ-------IMASNAFSFEATGKLAGTYDIQ--LIGKFNQENAMAAGLACLRLGASLEDIQKGIAQ-TPVPG 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2252828254 317 RVDVEKLTEHITLIDDsYNASVPAMKAAVDLLAQFKQGQRWLILG 361
Cdd:PRK14022 330 RMEVLTQSNGAKVFID-YAHNGDSLNKLIDVVEEHQKGKLILLLG 373
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
96-414 |
3.12e-18 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 86.67 E-value: 3.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 96 RRCGTKTLAITGSCGKTTVKEMVASILSGLGQVLYTAGNfnndIGVP-LTLLRSTPQDDFSVIEL------GANHIgeia 168
Cdd:COG0771 101 RLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGN----IGTPlLDLLLEPEPPDVYVLELssfqleTTPSL---- 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 169 yttalvKPDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSqgESIWSEVLQ-DKNLITFS-KQNTNA 246
Cdd:COG0771 173 ------RPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDDYAVLNADD--PLTRALAEEaKARVVPFSlKEPLEG 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 247 DFY--GSDIAMSSEGYPLFTLHtpignvelQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSKVKRRvdVEKLT 324
Cdd:COG0771 245 GAGleDGKLVDRASGEELLPVD--------DLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHR--LEFVA 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 325 EH--ITLIDDS----YNASVPAMKAavdllaqFKqGQRWLILGnmaelGH------ESLAlhKEVGQHAApfafeHVLTY 392
Cdd:COG0771 315 EIngVRFINDSkatnPDATLAALES-------FD-GPVVLIAG-----GLdkgadfSPLA--PAVAERVK-----AVVLI 374
|
330 340
....*....|....*....|....
gi 2252828254 393 GEDAKVISDLCGGMHFQSH--DSM 414
Cdd:COG0771 375 GEDAEKIAAALAGAGVPVVivETM 398
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
101-444 |
9.25e-15 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 75.84 E-value: 9.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 101 KTLAITGSCGKTTVKEMVASILSGLGQVLYTAGNfnndIGVPLTLLRSTPQDDFSVIELGAnhiGEIAYTTALvKPDIAM 180
Cdd:TIGR01087 103 PVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGN----IGTPALEVLDQEGAELYVLELSS---FQLETTESL-RPEIAL 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 181 VNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQGESIWSEVLQDKnLITFSKQNtNADFygsDIAMSSEGY 260
Cdd:TIGR01087 175 ILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKSKAQ-VIWFSVEK-DAER---GLCIRDGGL 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 261 PLFtlhtpigNVELQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSKVKRRVDVEKLTEHITLIDDSYNASVPA 340
Cdd:TIGR01087 250 YLK-------PNDLEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYNDSKATNVHA 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 341 MKAAvdlLAQFKqGQRWLILGNMAElGHESLALHKEVGQHAApfafeHVLTYGEDAKVISDLCG--GMHFQSHDSMLEYI 418
Cdd:TIGR01087 323 TLAA---LSAFD-NPVILIVGGDDK-GADFSPLAPAAAGKVK-----AVLAIGEDAAKIAPLLKeaGLSVYLVESLEEAV 392
|
330 340
....*....|....*....|....*.
gi 2252828254 419 ERNLTQLNQTSHTLLVKGALSAGMYT 444
Cdd:TIGR01087 393 QAAREVASPGDVVLLSPACASFDQFK 418
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
99-332 |
4.56e-14 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 73.95 E-value: 4.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 99 GTKTLAITGSCGKTTVKEMVASILSGLGQ--------VLytagnfnNDIGVPLTLlrstPQDDFSVIElganhigeiA-- 168
Cdd:COG0773 103 GKRSIAVAGTHGKTTTTSMLAHILEEAGLdptfliggIL-------NNFGTNARL----GDGDYFVAE---------Ade 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 169 YTTALVK--PDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQG-----ESIWSEVlqdknlITFSk 241
Cdd:COG0773 163 SDGSFLHysPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDPGlrellPRCGRPV------ITYG- 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 242 QNTNADFYGSDIAMSSEGYpLFTLH---TPIGNVELQLslLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSKVKRRV 318
Cdd:COG0773 236 FSEDADYRAENIRIDGGGS-TFDVLrrgEELGEVELNL--PGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRF 312
|
250
....*....|....
gi 2252828254 319 DVEKLTEHITLIDD 332
Cdd:COG0773 313 ELKGEVGGVTVIDD 326
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
314-391 |
1.88e-10 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 56.97 E-value: 1.88e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2252828254 314 VKRRVDVEKLTEHITLIDDsYNASVPAMKAAVDLLAQFKQGQRWLILGNMaelGHESLALHKEVGQHAAPFAFEHVLT 391
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNLFPGRLILVFGGM---GDRDAEFHALLGRLAAALADVVILT 74
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
24-69 |
2.05e-09 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 54.16 E-value: 2.05e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 2252828254 24 IQEVTTDTRAIQSGALFIALVGERFDAHDFCQQAADKGAAALIVER 69
Cdd:pfam01225 2 IHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHD 47
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
102-332 |
2.85e-09 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 58.86 E-value: 2.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 102 TLAITGSCGKTTVKEMVASILSGLGQV-------LYTAGNFNNDIGVPLTLLRSTPQDDFSVIELGanhigeiayttalv 174
Cdd:TIGR01082 101 SIAVAGTHGKTTTTAMIAVILKEAGLDptvvvggLVKEAGTNARLGSGEYLVAEADESDASFLHLQ-------------- 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 175 kPDIAMVNNVAEAHLEGFG-SLDGVKTAKGEIYQGLTANGTALINLDSQGESIWSEVLQDKnLITFSKQNTNADFYGSDI 253
Cdd:TIGR01082 167 -PNVAIVTNIEPDHLDTYGsSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKATEQ-VITYGGSGEDADYRAENI 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 254 AMSSEgYPLFTLHTPIGNV-ELQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSKVKRRVDVEKLTEHITLIDD 332
Cdd:TIGR01082 245 QQSGA-EGKFSVRGKGKLYlEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEILGEFGGVLLIDD 323
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
96-333 |
3.24e-08 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 55.75 E-value: 3.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 96 RRCGTKTLAITGSCGKTTVKEMVASILSGLGQVLYTAGNfnndIGVPL--TLLRSTPqDDFSVIELGANHIGEIAYttal 173
Cdd:PRK14106 104 RFSKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGN----IGYPLidAVEEYGE-DDIIVAEVSSFQLETIKE---- 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 174 VKPDIAMVNNVAEAHLEGFGSLDGVKTAKGEIYQGLTANGTALINLDSQgeSIWSEVLQDK-NLITFSKQNTNADFYGSD 252
Cdd:PRK14106 175 FKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDP--RTRSLAKKAKaRVIFFSRKSLLEEGVFVK 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 253 ---IAMSSEGYPlftlhTPIGNVElQLSLLGEHNVANAVAASALAIQCGATLEQIKIGLQSLSKVKRRVDVEKLTEHITL 329
Cdd:PRK14106 253 ngkIVISLGGKE-----EEVIDID-EIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAEINGVKF 326
|
....
gi 2252828254 330 IDDS 333
Cdd:PRK14106 327 INDS 330
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
86-214 |
6.58e-03 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 38.85 E-value: 6.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252828254 86 ALGLLGAEVHRRCGTKTLAITGSCGKTTVKEMVASILSGLGQVLYT-AGNFNNDIGVPLTLLRSTPQddfSVIElganhI 164
Cdd:NF033197 78 AVGEILKKKYGRIPKKFIEITGVKGKTTTAELLAHILSDEYVLLHTsRGTERYPEGELSNKGSITPA---SILN-----A 149
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2252828254 165 GEIAYTTALVKPDIAmvnnVAEAHLEGFGSLD-GVKTAKGEIYqgLTANGT 214
Cdd:NF033197 150 LELAEEIGIDDYGFL----IFEVSLGGTGAGDvGIITNILEDY--PIAGGK 194
|
|
| |
