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Conserved domains on  [gi|2294650098|gb|UWB42591|]
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hypothetical protein M5S57_28550 (plasmid) [Klebsiella pneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MatP super family cl23842
MatP N-terminal domain; This family, many of whose members are YcbG, organizes the macrodomain ...
 35-110 3.31e-07

MatP N-terminal domain; This family, many of whose members are YcbG, organizes the macrodomain Ter of the chromosome of bacteria such as E coli. In these bacteria, insulated macrodomains influence the segregation of sister chromatids and the mobility of chromosomal DNA. organization of the Terminus region (Ter) into a macrodomain relies on the presence of a 13 bp motif called matS repeated 23 times in the 800-kb-long domain. MatS sites are the main targets in the E. coli chromosome of YcbG or MatP (macrodomain Ter protein). MatP accumulates in the cell as a discrete focus that co-localizes with the Ter macrodomain. The effects of MatP inactivation reveal its role as the main organizer of the Ter macrodomain: in the absence of MatP, DNA is less compacted, the mobility of markers is increased, and segregation of the Ter macrodomain occurs early in the cell cycle. A specific organizational system is required in the Terminus region for bacterial chromosome management during the cell cycle. This entry represents the N-terminal domain of MatP.


The actual alignment was detected with superfamily member PRK05097:

Pssm-ID: 451574 [Multi-domain]  Cd Length: 150  Bit Score: 46.11  E-value: 3.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294650098  35 EAVDSLNSIGRSPSELTEWINKYLTAEQINKLGTSIRQRRRRGYGV------GKSItisDKAHRILKRLSEVD---GCSL 105
Cdd:PRK05097   39 EAVDELLKLENEPVKVLEWIDKHMNPELVNRMKQTIRARRKRHFNAehqhtrKKSI---DLEYRVWQRLAGLAqrrGKTL 115


                  ....*
gi 2294650098 106 SEVIE 110
Cdd:PRK05097  116 SETIV 120
 
Name Accession Description Interval E-value
PRK05097 PRK05097
macrodomain Ter protein MatP;
35-110 3.31e-07

macrodomain Ter protein MatP;


Pssm-ID: 235344 [Multi-domain]  Cd Length: 150  Bit Score: 46.11  E-value: 3.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294650098  35 EAVDSLNSIGRSPSELTEWINKYLTAEQINKLGTSIRQRRRRGYGV------GKSItisDKAHRILKRLSEVD---GCSL 105
Cdd:PRK05097   39 EAVDELLKLENEPVKVLEWIDKHMNPELVNRMKQTIRARRKRHFNAehqhtrKKSI---DLEYRVWQRLAGLAqrrGKTL 115


                  ....*
gi 2294650098 106 SEVIE 110
Cdd:PRK05097  116 SETIV 120
MatP pfam06303
MatP N-terminal domain; This family, many of whose members are YcbG, organizes the macrodomain ...
 35-76 3.77e-06

MatP N-terminal domain; This family, many of whose members are YcbG, organizes the macrodomain Ter of the chromosome of bacteria such as E coli. In these bacteria, insulated macrodomains influence the segregation of sister chromatids and the mobility of chromosomal DNA. organization of the Terminus region (Ter) into a macrodomain relies on the presence of a 13 bp motif called matS repeated 23 times in the 800-kb-long domain. MatS sites are the main targets in the E. coli chromosome of YcbG or MatP (macrodomain Ter protein). MatP accumulates in the cell as a discrete focus that co-localizes with the Ter macrodomain. The effects of MatP inactivation reveal its role as the main organizer of the Ter macrodomain: in the absence of MatP, DNA is less compacted, the mobility of markers is increased, and segregation of the Ter macrodomain occurs early in the cell cycle. A specific organizational system is required in the Terminus region for bacterial chromosome management during the cell cycle. This entry represents the N-terminal domain of MatP.


Pssm-ID: 428878  Cd Length: 84  Bit Score: 42.06  E-value: 3.77e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2294650098  35 EAVDSLNSIGRSPSELTEWINKYLTAEQINKLGTSIRQRRRR 76
Cdd:pfam06303  38 AAVQQLLKLENEPVKVEEWIKAHMNPELENKLKQAIRARRKR 79
 
Name Accession Description Interval E-value
PRK05097 PRK05097
macrodomain Ter protein MatP;
35-110 3.31e-07

macrodomain Ter protein MatP;


Pssm-ID: 235344 [Multi-domain]  Cd Length: 150  Bit Score: 46.11  E-value: 3.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2294650098  35 EAVDSLNSIGRSPSELTEWINKYLTAEQINKLGTSIRQRRRRGYGV------GKSItisDKAHRILKRLSEVD---GCSL 105
Cdd:PRK05097   39 EAVDELLKLENEPVKVLEWIDKHMNPELVNRMKQTIRARRKRHFNAehqhtrKKSI---DLEYRVWQRLAGLAqrrGKTL 115


                  ....*
gi 2294650098 106 SEVIE 110
Cdd:PRK05097  116 SETIV 120
MatP pfam06303
MatP N-terminal domain; This family, many of whose members are YcbG, organizes the macrodomain ...
 35-76 3.77e-06

MatP N-terminal domain; This family, many of whose members are YcbG, organizes the macrodomain Ter of the chromosome of bacteria such as E coli. In these bacteria, insulated macrodomains influence the segregation of sister chromatids and the mobility of chromosomal DNA. organization of the Terminus region (Ter) into a macrodomain relies on the presence of a 13 bp motif called matS repeated 23 times in the 800-kb-long domain. MatS sites are the main targets in the E. coli chromosome of YcbG or MatP (macrodomain Ter protein). MatP accumulates in the cell as a discrete focus that co-localizes with the Ter macrodomain. The effects of MatP inactivation reveal its role as the main organizer of the Ter macrodomain: in the absence of MatP, DNA is less compacted, the mobility of markers is increased, and segregation of the Ter macrodomain occurs early in the cell cycle. A specific organizational system is required in the Terminus region for bacterial chromosome management during the cell cycle. This entry represents the N-terminal domain of MatP.


Pssm-ID: 428878  Cd Length: 84  Bit Score: 42.06  E-value: 3.77e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2294650098  35 EAVDSLNSIGRSPSELTEWINKYLTAEQINKLGTSIRQRRRR 76
Cdd:pfam06303  38 AAVQQLLKLENEPVKVEEWIKAHMNPELENKLKQAIRARRKR 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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