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Conserved domains on  [gi|1738280112|emb|VAL64957|]
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zinc-binding protein [Enterobacter kobei]

Protein Classification

DNA gyrase inhibitor YacG( domain architecture ID 10011432)

DNA gyrase inhibitor YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA

Gene Symbol:  yacG
Gene Ontology:  GO:0008270|GO:0008657
PubMed:  18586829

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00418 PRK00418
DNA gyrase inhibitor YacG;
1-62 2.71e-37

DNA gyrase inhibitor YacG;


:

Pssm-ID: 234754  Cd Length: 62  Bit Score: 118.21  E-value: 2.71e-37
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1738280112  1 MSEVTTVNCPTCGKTVVWGEMSPFRPFCCKRCQLIDLGEWAAEEKRIPSKGDLSDSDDWSEE 62
Cdd:PRK00418   1 MSETITVNCPTCGKPVEWGEISPFRPFCSKRCQLIDLGEWAAEEKRIPSSGDLSESDDWSEE 62
 
Name Accession Description Interval E-value
PRK00418 PRK00418
DNA gyrase inhibitor YacG;
1-62 2.71e-37

DNA gyrase inhibitor YacG;


Pssm-ID: 234754  Cd Length: 62  Bit Score: 118.21  E-value: 2.71e-37
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1738280112  1 MSEVTTVNCPTCGKTVVWGEMSPFRPFCCKRCQLIDLGEWAAEEKRIPSKGDLSDSDDWSEE 62
Cdd:PRK00418   1 MSETITVNCPTCGKPVEWGEISPFRPFCSKRCQLIDLGEWAAEEKRIPSSGDLSESDDWSEE 62
YacG COG3024
Endogenous inhibitor of DNA gyrase, YacG/DUF329 family [Replication, recombination and repair]; ...
 5-61 4.71e-28

Endogenous inhibitor of DNA gyrase, YacG/DUF329 family [Replication, recombination and repair];


Pssm-ID: 442260  Cd Length: 58  Bit Score: 94.65  E-value: 4.71e-28
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 1738280112  5 TTVNCPTCGKTVVWGEMSPFRPFCCKRCQLIDLGEWAAEEKRIPSKGDLSDSDDWSE 61
Cdd:COG3024    2 TKVPCPICGKPVEWSPENPYRPFCSKRCKLIDLGRWLSEEYRIPGEPLDDDEEDPEE 58
YacG pfam03884
DNA gyrase inhibitor YacG; YacG inhibits all the catalytic activities of DNA gyrase by ...
 7-54 1.93e-23

DNA gyrase inhibitor YacG; YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. YacG has been shown to bind zinc and contains the structural motifs typical of zinc-binding proteins. The conserved four cysteine motif in this protein (-C-X(2)-C-X(15)-C-X(3)-C-) is not found in other zinc-binding proteins with known structures.


Pssm-ID: 427566  Cd Length: 48  Bit Score: 82.69  E-value: 1.93e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 1738280112  7 VNCPTCGKTVVWGEMSPFRPFCCKRCQLIDLGEWAAEEKRIPSKGDLS 54
Cdd:pfam03884  1 VRCPTCGKPVEWSPENPFRPFCSERCKLIDLGAWADEEYRIPGEPPPD 48
 
Name Accession Description Interval E-value
PRK00418 PRK00418
DNA gyrase inhibitor YacG;
1-62 2.71e-37

DNA gyrase inhibitor YacG;


Pssm-ID: 234754  Cd Length: 62  Bit Score: 118.21  E-value: 2.71e-37
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1738280112  1 MSEVTTVNCPTCGKTVVWGEMSPFRPFCCKRCQLIDLGEWAAEEKRIPSKGDLSDSDDWSEE 62
Cdd:PRK00418   1 MSETITVNCPTCGKPVEWGEISPFRPFCSKRCQLIDLGEWAAEEKRIPSSGDLSESDDWSEE 62
YacG COG3024
Endogenous inhibitor of DNA gyrase, YacG/DUF329 family [Replication, recombination and repair]; ...
 5-61 4.71e-28

Endogenous inhibitor of DNA gyrase, YacG/DUF329 family [Replication, recombination and repair];


Pssm-ID: 442260  Cd Length: 58  Bit Score: 94.65  E-value: 4.71e-28
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 1738280112  5 TTVNCPTCGKTVVWGEMSPFRPFCCKRCQLIDLGEWAAEEKRIPSKGDLSDSDDWSE 61
Cdd:COG3024    2 TKVPCPICGKPVEWSPENPYRPFCSKRCKLIDLGRWLSEEYRIPGEPLDDDEEDPEE 58
YacG pfam03884
DNA gyrase inhibitor YacG; YacG inhibits all the catalytic activities of DNA gyrase by ...
 7-54 1.93e-23

DNA gyrase inhibitor YacG; YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. YacG has been shown to bind zinc and contains the structural motifs typical of zinc-binding proteins. The conserved four cysteine motif in this protein (-C-X(2)-C-X(15)-C-X(3)-C-) is not found in other zinc-binding proteins with known structures.


Pssm-ID: 427566  Cd Length: 48  Bit Score: 82.69  E-value: 1.93e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 1738280112  7 VNCPTCGKTVVWGEMSPFRPFCCKRCQLIDLGEWAAEEKRIPSKGDLS 54
Cdd:pfam03884  1 VRCPTCGKPVEWSPENPFRPFCSERCKLIDLGAWADEEYRIPGEPPPD 48
PRK01343 PRK01343
zinc-binding protein; Provisional
 9-58 5.74e-06

zinc-binding protein; Provisional


Pssm-ID: 234943  Cd Length: 57  Bit Score: 38.92  E-value: 5.74e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 1738280112  9 CPTCGKTvvwgEMSPFRPFCCKRCQLIDLGEWAAEEKRIPSKGDLSDSDD 58
Cdd:PRK01343  12 CPECGKP----STREAYPFCSERCRDIDLNRWLSGSYVIPGAPDEEDDEE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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