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Conserved domains on  [gi|1738831293|emb|VAS52027|]
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antirestriction protein [Klebsiella pneumoniae]

Protein Classification

ArdC family protein( domain architecture ID 11468014)

ArdC family protein is a DUF1738 domain-containing protein; similar to antirestriction protein ArdC

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ArdC COG4227
Antirestriction protein ArdC [Replication, recombination and repair];
34-300 4.19e-155

Antirestriction protein ArdC [Replication, recombination and repair];


:

Pssm-ID: 443371 [Multi-domain]  Cd Length: 303  Bit Score: 435.82  E-value: 4.19e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1738831293  34 SKNKTKTDIYQTVTDSIIEALEMGVKPWVCPWKRNGSVSGIPSNFMTGTAYSGMNIMLLWCSAAKQGFNDSRWLTYKQAQ 113
Cdd:COG4227     2 AAAKPRKDIYQEVTDRIIAALEAGTLPWRKPWNSSGAGLGLPLNAATGRPYRGINVLLLWMAAEERGYTSPRWLTFKQAK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1738831293 114 EQGAQVRKGERGTTAIFYKTLEKEAEDGE-------IEKIPMLKTFTVFNVEQIDGLTLTEEDTAEPVSEFDPLPHVEAL 186
Cdd:COG4227    82 ELGGQVRKGEKGTLVVYYKRFEKEDEDEEdeegeevERRIPFLKAYTVFNAEQIDGLPEEYYPLPEPLPESERIERAEAF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1738831293 187 FQRTGANITERGQQAFFRPATDEIWLPERHLFTDAANFYATGLHELVHWTGAKSRLNREKCGRFGSEGYAFEELIAELGS 266
Cdd:COG4227   162 IAATGADIRHGGDRAFYSPSTDRIQMPPREQFKDAEDYYATLLHELGHWTGHKSRLNRDLGGRFGSEAYAFEELVAELGS 241
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1738831293 267 AFLMADLGITGDV--QHESYIASWLKSLRDDKRYIF 300
Cdd:COG4227   242 AFLCAELGIAPEPreNHAAYIASWLKVLKEDKRAIF 277
 
Name Accession Description Interval E-value
ArdC COG4227
Antirestriction protein ArdC [Replication, recombination and repair];
34-300 4.19e-155

Antirestriction protein ArdC [Replication, recombination and repair];


Pssm-ID: 443371 [Multi-domain]  Cd Length: 303  Bit Score: 435.82  E-value: 4.19e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1738831293  34 SKNKTKTDIYQTVTDSIIEALEMGVKPWVCPWKRNGSVSGIPSNFMTGTAYSGMNIMLLWCSAAKQGFNDSRWLTYKQAQ 113
Cdd:COG4227     2 AAAKPRKDIYQEVTDRIIAALEAGTLPWRKPWNSSGAGLGLPLNAATGRPYRGINVLLLWMAAEERGYTSPRWLTFKQAK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1738831293 114 EQGAQVRKGERGTTAIFYKTLEKEAEDGE-------IEKIPMLKTFTVFNVEQIDGLTLTEEDTAEPVSEFDPLPHVEAL 186
Cdd:COG4227    82 ELGGQVRKGEKGTLVVYYKRFEKEDEDEEdeegeevERRIPFLKAYTVFNAEQIDGLPEEYYPLPEPLPESERIERAEAF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1738831293 187 FQRTGANITERGQQAFFRPATDEIWLPERHLFTDAANFYATGLHELVHWTGAKSRLNREKCGRFGSEGYAFEELIAELGS 266
Cdd:COG4227   162 IAATGADIRHGGDRAFYSPSTDRIQMPPREQFKDAEDYYATLLHELGHWTGHKSRLNRDLGGRFGSEAYAFEELVAELGS 241
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1738831293 267 AFLMADLGITGDV--QHESYIASWLKSLRDDKRYIF 300
Cdd:COG4227   242 AFLCAELGIAPEPreNHAAYIASWLKVLKEDKRAIF 277
MPTase-PolyVal pfam18818
Zincin-like metallopeptidase; Zincin-like Metallopeptidase frequently found in polyvalent ...
181-300 8.39e-72

Zincin-like metallopeptidase; Zincin-like Metallopeptidase frequently found in polyvalent proteins of phages and conjugative elements. The active site is comprised of a HEXXH motif and a C-terminal glutamate.


Pssm-ID: 465878  Cd Length: 126  Bit Score: 217.73  E-value: 8.39e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1738831293 181 PHVEALFQRTGANITERGQQAFFRPATDEIWLPERHLFTDAANFYATGLHELVHWTGAKSRLNREKCGRFGSEGYAFEEL 260
Cdd:pfam18818   1 ERAEAFFAATGADIRHGGDRAFYSPSTDHIQMPPFEAFRDAENYYATLLHELGHWTGHESRLDRDLSGRFGSEAYAREEL 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1738831293 261 IAELGSAFLMADLGITGDV-QHESYIASWLKSLRDDKRYIF 300
Cdd:pfam18818  81 VAELGSAFLCADLGIVPEPrDHAAYIASWLKVLKDDKRAIF 121
 
Name Accession Description Interval E-value
ArdC COG4227
Antirestriction protein ArdC [Replication, recombination and repair];
34-300 4.19e-155

Antirestriction protein ArdC [Replication, recombination and repair];


Pssm-ID: 443371 [Multi-domain]  Cd Length: 303  Bit Score: 435.82  E-value: 4.19e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1738831293  34 SKNKTKTDIYQTVTDSIIEALEMGVKPWVCPWKRNGSVSGIPSNFMTGTAYSGMNIMLLWCSAAKQGFNDSRWLTYKQAQ 113
Cdd:COG4227     2 AAAKPRKDIYQEVTDRIIAALEAGTLPWRKPWNSSGAGLGLPLNAATGRPYRGINVLLLWMAAEERGYTSPRWLTFKQAK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1738831293 114 EQGAQVRKGERGTTAIFYKTLEKEAEDGE-------IEKIPMLKTFTVFNVEQIDGLTLTEEDTAEPVSEFDPLPHVEAL 186
Cdd:COG4227    82 ELGGQVRKGEKGTLVVYYKRFEKEDEDEEdeegeevERRIPFLKAYTVFNAEQIDGLPEEYYPLPEPLPESERIERAEAF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1738831293 187 FQRTGANITERGQQAFFRPATDEIWLPERHLFTDAANFYATGLHELVHWTGAKSRLNREKCGRFGSEGYAFEELIAELGS 266
Cdd:COG4227   162 IAATGADIRHGGDRAFYSPSTDRIQMPPREQFKDAEDYYATLLHELGHWTGHKSRLNRDLGGRFGSEAYAFEELVAELGS 241
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1738831293 267 AFLMADLGITGDV--QHESYIASWLKSLRDDKRYIF 300
Cdd:COG4227   242 AFLCAELGIAPEPreNHAAYIASWLKVLKEDKRAIF 277
MPTase-PolyVal pfam18818
Zincin-like metallopeptidase; Zincin-like Metallopeptidase frequently found in polyvalent ...
181-300 8.39e-72

Zincin-like metallopeptidase; Zincin-like Metallopeptidase frequently found in polyvalent proteins of phages and conjugative elements. The active site is comprised of a HEXXH motif and a C-terminal glutamate.


Pssm-ID: 465878  Cd Length: 126  Bit Score: 217.73  E-value: 8.39e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1738831293 181 PHVEALFQRTGANITERGQQAFFRPATDEIWLPERHLFTDAANFYATGLHELVHWTGAKSRLNREKCGRFGSEGYAFEEL 260
Cdd:pfam18818   1 ERAEAFFAATGADIRHGGDRAFYSPSTDHIQMPPFEAFRDAENYYATLLHELGHWTGHESRLDRDLSGRFGSEAYAREEL 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1738831293 261 IAELGSAFLMADLGITGDV-QHESYIASWLKSLRDDKRYIF 300
Cdd:pfam18818  81 VAELGSAFLCADLGIVPEPrDHAAYIASWLKVLKDDKRAIF 121
ArdcN pfam08401
N-terminal domain of anti-restriction factor ArdC; This is the ssDNA binding domain of ...
40-155 1.33e-50

N-terminal domain of anti-restriction factor ArdC; This is the ssDNA binding domain of anti-restriction factor ArdC deployed by plasmids and phages in polyvalent proteins related to the BHD domains of XPC/Rad4 and the Tc-38 domain found in kinetoplastid minicircle binding proteins. The structure of this domain is composed of three alpha-helices and a three-stranded beta-sheet that supports a long and protuberant beta-hairpin. This domain is also found in the N-terminal region of the RP4 TraC1 primase, together with the Toprim domain (pfam01751, pfam13362 and pfam13662).


Pssm-ID: 429975  Cd Length: 127  Bit Score: 163.67  E-value: 1.33e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1738831293  40 TDIYQTVTDSIIEALEMGVKPWVCPWKRNGSvSGIPSNFMTGTAYSGMNIMLLWCSAAKQGFNDSRWLTYKQAQEQGAQV 119
Cdd:pfam08401   1 KDLYERITDQIIEALEAGVGPWQKPWSTGGA-GGLPRNAATGRPYSGINVLLLWLAAPEAGYTSPRWLTFKQAKELGGQV 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1738831293 120 RKGERGTTAIFYKTLEKEAEDGEIEK------------IPMLKTFTVF 155
Cdd:pfam08401  80 RKGEKGTPVVYYKFFVKEDEDDKDYKeadeegeeeereIPFLKTYTVF 127
Tox-MPTase3 pfam15639
Metallopeptidase toxin 3; A zincin-like metallopeptidase domain found in bacterial polymorphic ...
226-261 8.25e-04

Metallopeptidase toxin 3; A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems.


Pssm-ID: 406147  Cd Length: 137  Bit Score: 39.13  E-value: 8.25e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1738831293 226 ATGLHELVHWTGAKSRLNRekcgrfGSEGYAFEELI 261
Cdd:pfam15639 106 ATVLHELIHWTRWKNGLDA------GEEGKAFEAEA 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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