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Conserved domains on  [gi|1737589400|emb|VAT90370|]
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multiple antibiotic resistance protein MarC [Klebsiella pneumoniae]

Protein Classification

MarC family protein( domain architecture ID 10013699)

MarC integral membrane family protein with unknown function similar to Escherichia coli MarC, which is involved in resistance to multiple antibiotics

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK10995 PRK10995
MarC family NAAT transporter;
1-221 8.59e-135

MarC family NAAT transporter;


:

Pssm-ID: 236814  Cd Length: 221  Bit Score: 377.38  E-value: 8.59e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400   1 MFDLFKAIGLGLAVLLPLANPLTTVALFLGLAGNMNNAERNKQALMASVYVFAILMVSWYAGQVVMNTFGISIPGLRIAG 80
Cdd:PRK10995    1 MLDLFKAIGLGLVVLLPLANPLTTVALFLGLSGNMTPEERNRQALMASVYVFAIMMVAFYAGQLVMSTFGISIPGLRIAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400  81 GLIVAFIGFRMLFPQQKAHDSMEAKIKSEELQDEPTANIAFVPLAMPSTAGPGTIAMIISSASTVKHGVDFPEWVVLAAP 160
Cdd:PRK10995   81 GLIVAFIGFRMLFPQQKAEDSPEAKSKSEELEDEPSANIAFVPLAMPSTAGPGTIAMIISSASTIAEGSTFADWVLMVAP 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1737589400 161 PIIFLLLGVILWACLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGVLEIISTWH 221
Cdd:PRK10995  161 PLIFLLVALILWGSLRSSGAIMRLLGKGGIEAISRLMGFLLVCMGVQFIINGILEIIKTYH 221
 
Name Accession Description Interval E-value
PRK10995 PRK10995
MarC family NAAT transporter;
1-221 8.59e-135

MarC family NAAT transporter;


Pssm-ID: 236814  Cd Length: 221  Bit Score: 377.38  E-value: 8.59e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400   1 MFDLFKAIGLGLAVLLPLANPLTTVALFLGLAGNMNNAERNKQALMASVYVFAILMVSWYAGQVVMNTFGISIPGLRIAG 80
Cdd:PRK10995    1 MLDLFKAIGLGLVVLLPLANPLTTVALFLGLSGNMTPEERNRQALMASVYVFAIMMVAFYAGQLVMSTFGISIPGLRIAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400  81 GLIVAFIGFRMLFPQQKAHDSMEAKIKSEELQDEPTANIAFVPLAMPSTAGPGTIAMIISSASTVKHGVDFPEWVVLAAP 160
Cdd:PRK10995   81 GLIVAFIGFRMLFPQQKAEDSPEAKSKSEELEDEPSANIAFVPLAMPSTAGPGTIAMIISSASTIAEGSTFADWVLMVAP 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1737589400 161 PIIFLLLGVILWACLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGVLEIISTWH 221
Cdd:PRK10995  161 PLIFLLVALILWGSLRSSGAIMRLLGKGGIEAISRLMGFLLVCMGVQFIINGILEIIKTYH 221
MarC pfam01914
MarC family integral membrane protein; Integral membrane protein family that includes the ...
5-217 2.12e-61

MarC family integral membrane protein; Integral membrane protein family that includes the protein MarC. MarC was thought to be a multiple antibiotic resistance protein. Nevertheless, a study has shown that MarC is not involved in multiple antibiotic resistance. The function of this family is unclear.


Pssm-ID: 280149  Cd Length: 203  Bit Score: 190.57  E-value: 2.12e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400   5 FKAIGLGLAVLLPLANPLTTVALFLGLAGNMNNAERNKQALMASVYVFAILMVSWYAGQVVMNTFGISIPGLRIAGGLIV 84
Cdd:pfam01914   1 LSFIFSAFVSLFAIINPLGNVPVFISLTENYSAEERNRIILRASIYALLILLVFLFFGDLILDLFGISIPAFRIAGGILL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400  85 AFIGFRMLFPQQKAhdsmEAKIKSEELQDEPTANIAFVPLAMPSTAGPGTIAMIISSASTVkhgvdfPEWVVLAAPPIIF 164
Cdd:pfam01914  81 FLIAIDMLFGKQPK----EKASKSEREESEDRDEIAVVPLAIPLIAGPGAITTTMVLGSTY------GTIVSKLAVVLAI 150
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1737589400 165 LLLGVILWACLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGVLEII 217
Cdd:pfam01914 151 LLAWLITFLILLSSSFIYRLLGRTGINALTRIMGLLLAAIAVQMIVDGIRGIF 203
MarC COG2095
Small neutral amino acid transporter SnatA, MarC family [Amino acid transport and metabolism];
4-220 7.52e-59

Small neutral amino acid transporter SnatA, MarC family [Amino acid transport and metabolism];


Pssm-ID: 441698  Cd Length: 206  Bit Score: 184.18  E-value: 7.52e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400   4 LFKAIGLGLAVLLPLANPLTTVALFLGLAGNMNNAERNKQALMASVYVFAILMVSWYAGQVVMNTFGISIPGLRIAGGLI 83
Cdd:COG2095     1 DLSLFLSAFVTLFAIIDPIGNVPIFLSLTKGLSPAERRRIALRASLIAFVILLVFALAGQLILSFFGISLPAFRIAGGIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400  84 VAFIGFRMLFPQQKAHDSMEAKikseelQDEPTANIAFVPLAMPSTAGPGTIAMIISSASTvkhgvdFPEWVVLAAPPII 163
Cdd:COG2095    81 LFLIALDMLFGKPSGEKETEAE------EAEDKEDIAVVPLAIPLLAGPGAIATVILLAAQ------APGLLGLLAVLLA 148
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1737589400 164 FLLLGVILWACLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGVLEIISTW 220
Cdd:COG2095   149 ILLVLLLTYLILLLAGRILRLLGETGINVLTRLMGLILAAIAVQMILDGIKGLFPGL 205
TIGR00427 TIGR00427
membrane protein, MarC family; MarC is a protein that spans the plasma membrane multiple times ...
3-213 2.16e-25

membrane protein, MarC family; MarC is a protein that spans the plasma membrane multiple times and once was thought to be a multiple antibiotic resistance protein. The function for this family is unknown. [Unknown function, General]


Pssm-ID: 129521  Cd Length: 201  Bit Score: 98.24  E-value: 2.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400   3 DLFKAIGLGLAVLLPLANPLTTVALFLGLAGNMNNAERNKQALMASVYVFAILMVSWYAGQVVMNTFGISIPGLRIAGGL 82
Cdd:TIGR00427   2 DILSFYFKFFISLFAIINPIGNIPIFISLTEYYTAAERNKIAKKANISSFIILLIFLVFGDTILKLFGISIDAFRIAGGI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400  83 IVAFIGFRMLFPQQKAHdsmeaKIKSEELQDEPTANIAFVPLAMPSTAGPGTIAMIIsSASTVKHGVDFPEWVVLAAppi 162
Cdd:TIGR00427  82 LLFTIAMDMLSGEGEDK-----QHKDEKEESAEIDSIAVVPLALPLIAGPGAITTTM-VLGARASSIGYKFLVVLAI--- 152
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1737589400 163 ifLLLGVILWACLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGV 213
Cdd:TIGR00427 153 --ALVALITWLLFRYSAFIIRRLGRTGINVITRIMGLLLAAIAVEFIVTGI 201
 
Name Accession Description Interval E-value
PRK10995 PRK10995
MarC family NAAT transporter;
1-221 8.59e-135

MarC family NAAT transporter;


Pssm-ID: 236814  Cd Length: 221  Bit Score: 377.38  E-value: 8.59e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400   1 MFDLFKAIGLGLAVLLPLANPLTTVALFLGLAGNMNNAERNKQALMASVYVFAILMVSWYAGQVVMNTFGISIPGLRIAG 80
Cdd:PRK10995    1 MLDLFKAIGLGLVVLLPLANPLTTVALFLGLSGNMTPEERNRQALMASVYVFAIMMVAFYAGQLVMSTFGISIPGLRIAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400  81 GLIVAFIGFRMLFPQQKAHDSMEAKIKSEELQDEPTANIAFVPLAMPSTAGPGTIAMIISSASTVKHGVDFPEWVVLAAP 160
Cdd:PRK10995   81 GLIVAFIGFRMLFPQQKAEDSPEAKSKSEELEDEPSANIAFVPLAMPSTAGPGTIAMIISSASTIAEGSTFADWVLMVAP 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1737589400 161 PIIFLLLGVILWACLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGVLEIISTWH 221
Cdd:PRK10995  161 PLIFLLVALILWGSLRSSGAIMRLLGKGGIEAISRLMGFLLVCMGVQFIINGILEIIKTYH 221
MarC pfam01914
MarC family integral membrane protein; Integral membrane protein family that includes the ...
5-217 2.12e-61

MarC family integral membrane protein; Integral membrane protein family that includes the protein MarC. MarC was thought to be a multiple antibiotic resistance protein. Nevertheless, a study has shown that MarC is not involved in multiple antibiotic resistance. The function of this family is unclear.


Pssm-ID: 280149  Cd Length: 203  Bit Score: 190.57  E-value: 2.12e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400   5 FKAIGLGLAVLLPLANPLTTVALFLGLAGNMNNAERNKQALMASVYVFAILMVSWYAGQVVMNTFGISIPGLRIAGGLIV 84
Cdd:pfam01914   1 LSFIFSAFVSLFAIINPLGNVPVFISLTENYSAEERNRIILRASIYALLILLVFLFFGDLILDLFGISIPAFRIAGGILL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400  85 AFIGFRMLFPQQKAhdsmEAKIKSEELQDEPTANIAFVPLAMPSTAGPGTIAMIISSASTVkhgvdfPEWVVLAAPPIIF 164
Cdd:pfam01914  81 FLIAIDMLFGKQPK----EKASKSEREESEDRDEIAVVPLAIPLIAGPGAITTTMVLGSTY------GTIVSKLAVVLAI 150
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1737589400 165 LLLGVILWACLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGVLEII 217
Cdd:pfam01914 151 LLAWLITFLILLSSSFIYRLLGRTGINALTRIMGLLLAAIAVQMIVDGIRGIF 203
MarC COG2095
Small neutral amino acid transporter SnatA, MarC family [Amino acid transport and metabolism];
4-220 7.52e-59

Small neutral amino acid transporter SnatA, MarC family [Amino acid transport and metabolism];


Pssm-ID: 441698  Cd Length: 206  Bit Score: 184.18  E-value: 7.52e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400   4 LFKAIGLGLAVLLPLANPLTTVALFLGLAGNMNNAERNKQALMASVYVFAILMVSWYAGQVVMNTFGISIPGLRIAGGLI 83
Cdd:COG2095     1 DLSLFLSAFVTLFAIIDPIGNVPIFLSLTKGLSPAERRRIALRASLIAFVILLVFALAGQLILSFFGISLPAFRIAGGIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400  84 VAFIGFRMLFPQQKAHDSMEAKikseelQDEPTANIAFVPLAMPSTAGPGTIAMIISSASTvkhgvdFPEWVVLAAPPII 163
Cdd:COG2095    81 LFLIALDMLFGKPSGEKETEAE------EAEDKEDIAVVPLAIPLLAGPGAIATVILLAAQ------APGLLGLLAVLLA 148
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1737589400 164 FLLLGVILWACLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGVLEIISTW 220
Cdd:COG2095   149 ILLVLLLTYLILLLAGRILRLLGETGINVLTRLMGLILAAIAVQMILDGIKGLFPGL 205
PRK11111 PRK11111
YchE family NAAT transporter;
15-213 2.88e-35

YchE family NAAT transporter;


Pssm-ID: 236850  Cd Length: 214  Bit Score: 124.28  E-value: 2.88e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400  15 LLPLANPLTTVALFLGLAGNMNNAERNKQALMASVYVFAILMVSWYAGQVVMNTFGISIPGLRIAGGLIVAFIGFRMLfp 94
Cdd:PRK11111   17 LFALVNPVGILPVFISMTSHQTAAERNKTNLTANLSVAIILLISLFLGDFILNLFGISIDSFRIAGGILVVTIAMSMI-- 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400  95 QQK-AHDSMEAKIKSEELQDEptaNIAFVPLAMPSTAGPGTIamiissASTVKHGVDFPEWVVLAAPPIIFLLLGVILWA 173
Cdd:PRK11111   95 SGKlGEDKQNKQEKSETAVRE---SIGVVPLALPLMAGPGAI------SSTIVWGTRYHSWSNLLGFSVAIALFALCCWL 165
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1737589400 174 CLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGV 213
Cdd:PRK11111  166 LFRMAPWLVRLLGQTGINVITRIMGLLLMALGIEFIVTGI 205
TIGR00427 TIGR00427
membrane protein, MarC family; MarC is a protein that spans the plasma membrane multiple times ...
3-213 2.16e-25

membrane protein, MarC family; MarC is a protein that spans the plasma membrane multiple times and once was thought to be a multiple antibiotic resistance protein. The function for this family is unknown. [Unknown function, General]


Pssm-ID: 129521  Cd Length: 201  Bit Score: 98.24  E-value: 2.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400   3 DLFKAIGLGLAVLLPLANPLTTVALFLGLAGNMNNAERNKQALMASVYVFAILMVSWYAGQVVMNTFGISIPGLRIAGGL 82
Cdd:TIGR00427   2 DILSFYFKFFISLFAIINPIGNIPIFISLTEYYTAAERNKIAKKANISSFIILLIFLVFGDTILKLFGISIDAFRIAGGI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400  83 IVAFIGFRMLFPQQKAHdsmeaKIKSEELQDEPTANIAFVPLAMPSTAGPGTIAMIIsSASTVKHGVDFPEWVVLAAppi 162
Cdd:TIGR00427  82 LLFTIAMDMLSGEGEDK-----QHKDEKEESAEIDSIAVVPLALPLIAGPGAITTTM-VLGARASSIGYKFLVVLAI--- 152
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1737589400 163 ifLLLGVILWACLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGV 213
Cdd:TIGR00427 153 --ALVALITWLLFRYSAFIIRRLGRTGINVITRIMGLLLAAIAVEFIVTGI 201
PRK10739 PRK10739
YhgN family NAAT transporter;
14-213 5.54e-08

YhgN family NAAT transporter;


Pssm-ID: 170674  Cd Length: 197  Bit Score: 51.24  E-value: 5.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400  14 VLLPLANPLTTVALFLGLAGNMNNAERNKQALMASVYVFAILMVSWYAGQVVMNTFGISIPGLRIAGGLIVAFIGFRMLF 93
Cdd:PRK10739   10 LLILIMDPLGNLPIFMSVLKHLEPKRRRAIMIRELLIALLVMLVFLFAGEKILAFLNLRTETVSISGGIILFLIAIKMIF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737589400  94 PQQKAHDSMEAKikseelQDEPTaniaFVPLAMPSTAGPGTIAMIISSASTVKHGVDFPEWVVLAAPPIIFLLlgvilwa 173
Cdd:PRK10739   90 PSAEGNSSGLPA------GEEPF----LVPLAIPLVAGPSILATLMLLSHQYPNQMGHLVIALLIAWGGTFVI------- 152
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1737589400 174 cLRSSGAIMRLVGKGGIEAISRLMGFLLVCMGVQFIINGV 213
Cdd:PRK10739  153 -LLQSSLFLRLLGEKGVNALERLMGLILVMLSTQMFLDGI 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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