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Conserved domains on  [gi|1539182854|emb|VDY40270|]
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transcriptional regulator [Salmonella enterica subsp. enterica serovar Daytona]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10444001)

LysR family helix-turn-helix (HTH) domain-containing protein binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  10473770|15808743|9309218

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LysR super family cl43195
DNA-binding transcriptional regulator, LysR family [Transcription];
1-62 4.30e-19

DNA-binding transcriptional regulator, LysR family [Transcription];


The actual alignment was detected with superfamily member COG0583:

Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 76.83  E-value: 4.30e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539182854   1 MTLTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKeIELTAAG 62
Cdd:COG0583     1 MDLRQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRG-LRLTEAG 61
 
Name Accession Description Interval E-value
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
1-62 4.30e-19

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 76.83  E-value: 4.30e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539182854   1 MTLTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKeIELTAAG 62
Cdd:COG0583     1 MDLRQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRG-LRLTEAG 61
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
3-62 6.83e-18

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 68.95  E-value: 6.83e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539182854  3 LTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKeIELTAAG 62
Cdd:pfam00126  1 LRQLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRG-VRLTEAG 59
argP TIGR03298
transcriptional regulator, ArgP family; ArgP used to be known as IciA. ArgP is a positive ...
 5-62 1.34e-12

transcriptional regulator, ArgP family; ArgP used to be known as IciA. ArgP is a positive regulator of argK. It is a negative autoregulator in presence of arginine. It competes with DnaA for oriC iteron (13-mer) binding. It activates dnaA and nrd transcription. It has been demonstrated to be part of the pho regulon (). ArgP mutants convey canavanine (an L-arginine structural homolog) sensitivity. [Cellular processes, Toxin production and resistance, DNA metabolism, DNA replication, recombination, and repair, Regulatory functions, DNA interactions]


Pssm-ID: 274509 [Multi-domain]  Cd Length: 292  Bit Score: 59.54  E-value: 1.34e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1539182854   5 QIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERrkEIELTAAG 62
Cdd:TIGR03298   5 QLAALAAVVEEGSFERAAAALSVTPSAVSQRIKALEERLGQPLLVRTQ--PCRATEAG 60
PRK03635 PRK03635
ArgP/LysG family DNA-binding transcriptional regulator;
5-62 2.76e-12

ArgP/LysG family DNA-binding transcriptional regulator;


Pssm-ID: 235144 [Multi-domain]  Cd Length: 294  Bit Score: 58.63  E-value: 2.76e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1539182854   5 QIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERrkEIELTAAG 62
Cdd:PRK03635    6 QLEALAAVVREGSFERAAQKLHITQSAVSQRIKALEERVGQVLLVRTQ--PCRPTEAG 61
decaheme_TF NF041036
multiheme cytochrome-associated LysR family transcriptional regulator; Members of this family, ...
 9-62 1.85e-07

multiheme cytochrome-associated LysR family transcriptional regulator; Members of this family, including founding member GSU2202 from Geobacter sulfurreducens PCA, are LysR family transcriptional regulators found regularly in the vicinity of multiheme cytochromes such as GSU2203, a decaheme c-type cytochrome.


Pssm-ID: 468965 [Multi-domain]  Cd Length: 301  Bit Score: 45.50  E-value: 1.85e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1539182854   9 LLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRErRKEIELTAAG 62
Cdd:NF041036    9 LVIVAEEGSFSKAAEKLHLTQSAVSQRIKFLEECYGYQLFDRS-GPSLEPTAAG 61
 
Name Accession Description Interval E-value
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
1-62 4.30e-19

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 76.83  E-value: 4.30e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539182854   1 MTLTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKeIELTAAG 62
Cdd:COG0583     1 MDLRQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRG-LRLTEAG 61
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
3-62 6.83e-18

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 68.95  E-value: 6.83e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539182854  3 LTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKeIELTAAG 62
Cdd:pfam00126  1 LRQLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRG-VRLTEAG 59
argP TIGR03298
transcriptional regulator, ArgP family; ArgP used to be known as IciA. ArgP is a positive ...
 5-62 1.34e-12

transcriptional regulator, ArgP family; ArgP used to be known as IciA. ArgP is a positive regulator of argK. It is a negative autoregulator in presence of arginine. It competes with DnaA for oriC iteron (13-mer) binding. It activates dnaA and nrd transcription. It has been demonstrated to be part of the pho regulon (). ArgP mutants convey canavanine (an L-arginine structural homolog) sensitivity. [Cellular processes, Toxin production and resistance, DNA metabolism, DNA replication, recombination, and repair, Regulatory functions, DNA interactions]


Pssm-ID: 274509 [Multi-domain]  Cd Length: 292  Bit Score: 59.54  E-value: 1.34e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1539182854   5 QIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERrkEIELTAAG 62
Cdd:TIGR03298   5 QLAALAAVVEEGSFERAAAALSVTPSAVSQRIKALEERLGQPLLVRTQ--PCRATEAG 60
PRK03635 PRK03635
ArgP/LysG family DNA-binding transcriptional regulator;
5-62 2.76e-12

ArgP/LysG family DNA-binding transcriptional regulator;


Pssm-ID: 235144 [Multi-domain]  Cd Length: 294  Bit Score: 58.63  E-value: 2.76e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1539182854   5 QIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERrkEIELTAAG 62
Cdd:PRK03635    6 QLEALAAVVREGSFERAAQKLHITQSAVSQRIKALEERVGQVLLVRTQ--PCRPTEAG 61
PRK13348 PRK13348
HTH-type transcriptional regulator ArgP;
5-62 5.16e-12

HTH-type transcriptional regulator ArgP;


Pssm-ID: 237357 [Multi-domain]  Cd Length: 294  Bit Score: 58.06  E-value: 5.16e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1539182854   5 QIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERrkEIELTAAG 62
Cdd:PRK13348    6 QLEALAAVVETGSFERAARRLHVTPSAVSQRIKALEESLGQPLLVRGR--PCRPTPAG 61
PRK11242 PRK11242
DNA-binding transcriptional regulator CynR; Provisional
 1-62 1.49e-10

DNA-binding transcriptional regulator CynR; Provisional


Pssm-ID: 183051 [Multi-domain]  Cd Length: 296  Bit Score: 54.19  E-value: 1.49e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539182854   1 MTLTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKeIELTAAG 62
Cdd:PRK11242    1 MLLRHIRYFLAVAEHGNFTRAAEALHVSQPTLSQQIRQLEESLGVQLFDRSGRT-VRLTDAG 61
PRK10086 PRK10086
DNA-binding transcriptional regulator DsdC;
3-62 4.18e-10

DNA-binding transcriptional regulator DsdC;


Pssm-ID: 182231 [Multi-domain]  Cd Length: 311  Bit Score: 52.70  E-value: 4.18e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539182854   3 LTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKeIELTAAG 62
Cdd:PRK10086   16 LSKLHTFEVAARHQSFALAADELSLTPSAVSHRINQLEEELGIKLFVRSHRK-VELTEEG 74
rbcR CHL00180
LysR transcriptional regulator; Provisional
 2-62 1.01e-09

LysR transcriptional regulator; Provisional


Pssm-ID: 177082 [Multi-domain]  Cd Length: 305  Bit Score: 51.94  E-value: 1.01e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1539182854   2 TLTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKeIELTAAG 62
Cdd:CHL00180    6 TLDQLRILKAIATEGSFKKAAESLYISQPAVSLQIKNLEKQLNIPLFDRSKNK-ASLTEAG 65
PRK09906 PRK09906
DNA-binding transcriptional regulator HcaR; Provisional
 1-62 2.29e-09

DNA-binding transcriptional regulator HcaR; Provisional


Pssm-ID: 182137 [Multi-domain]  Cd Length: 296  Bit Score: 50.92  E-value: 2.29e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539182854   1 MTLTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKeIELTAAG 62
Cdd:PRK09906    1 MELRHLRYFVAVAEELNFTKAAEKLHTAQPSLSQQIKDLENCVGVPLLVRDKRK-VALTAAG 61
PRK10632 PRK10632
HTH-type transcriptional activator AaeR;
12-62 3.35e-09

HTH-type transcriptional activator AaeR;


Pssm-ID: 182601 [Multi-domain]  Cd Length: 309  Bit Score: 50.14  E-value: 3.35e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1539182854  12 VLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKeIELTAAG 62
Cdd:PRK10632   13 VVEFGSFTAAARQLQMSVSSISQTVSKLEDELQVKLLNRSTRS-IGLTEAG 62
PRK12682 PRK12682
transcriptional regulator CysB-like protein; Reviewed
 19-50 6.35e-09

transcriptional regulator CysB-like protein; Reviewed


Pssm-ID: 183679 [Multi-domain]  Cd Length: 309  Bit Score: 49.60  E-value: 6.35e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1539182854  19 TEASKRLYMTQSAVSQAISALEEELGVDILIR 50
Cdd:PRK12682   20 TEAAKALHTSQPGVSKAIIELEEELGIEIFIR 51
PRK11074 PRK11074
putative DNA-binding transcriptional regulator; Provisional
 11-62 1.25e-08

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 182948 [Multi-domain]  Cd Length: 300  Bit Score: 48.78  E-value: 1.25e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1539182854  11 AVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVdILIRERRKEIELTAAG 62
Cdd:PRK11074   12 AVARTGSFSAAAQELHRVPSAVSYTVRQLEEWLAV-PLFERRHRDVELTPAG 62
PRK12684 PRK12684
CysB family HTH-type transcriptional regulator;
1-62 1.79e-08

CysB family HTH-type transcriptional regulator;


Pssm-ID: 237173 [Multi-domain]  Cd Length: 313  Bit Score: 48.43  E-value: 1.79e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1539182854   1 MTLTQIHALLAVLEYG-GFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKEIELTAAG 62
Cdd:PRK12684    1 MNLHQLRFVREAVRQNfNLTEAAKALYTSQPGVSKAIIELEDELGVEIFTRHGKRLRGLTEPG 63
PRK10837 PRK10837
putative DNA-binding transcriptional regulator; Provisional
 1-50 7.14e-08

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 182768 [Multi-domain]  Cd Length: 290  Bit Score: 46.60  E-value: 7.14e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1539182854   1 MTLTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIR 50
Cdd:PRK10837    3 ITLRQLEVFAEVLKSGSTTQASVMLALSQSAVSAALTDLEGQLGVQLFDR 52
PRK11139 PRK11139
DNA-binding transcriptional activator GcvA; Provisional
 18-62 9.30e-08

DNA-binding transcriptional activator GcvA; Provisional


Pssm-ID: 182990 [Multi-domain]  Cd Length: 297  Bit Score: 46.37  E-value: 9.30e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1539182854  18 FTEASKRLYMTQSAVSQAISALEEELGVDILIReRRKEIELTAAG 62
Cdd:PRK11139   23 FTRAAEELFVTQAAVSHQIKALEDFLGLKLFRR-RNRSLLLTEEG 66
PRK03601 PRK03601
HTH-type transcriptional regulator HdfR;
18-62 1.29e-07

HTH-type transcriptional regulator HdfR;


Pssm-ID: 235137 [Multi-domain]  Cd Length: 275  Bit Score: 45.78  E-value: 1.29e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1539182854  18 FTEASKRLYMTQSAVSQAISALEEELGVDILIRErRKEIELTAAG 62
Cdd:PRK03601   18 FGRAAESLYLTQSAVSFRIRQLENQLGVNLFTRH-RNNIRLTAAG 61
PRK12683 PRK12683
transcriptional regulator CysB-like protein; Reviewed
 19-62 1.50e-07

transcriptional regulator CysB-like protein; Reviewed


Pssm-ID: 237172 [Multi-domain]  Cd Length: 309  Bit Score: 45.80  E-value: 1.50e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1539182854  19 TEASKRLYMTQSAVSQAISALEEELGVDILIRERRKEIELTAAG 62
Cdd:PRK12683   20 TEVANALYTSQSGVSKQIKDLEDELGVEIFIRRGKRLTGLTEPG 63
decaheme_TF NF041036
multiheme cytochrome-associated LysR family transcriptional regulator; Members of this family, ...
 9-62 1.85e-07

multiheme cytochrome-associated LysR family transcriptional regulator; Members of this family, including founding member GSU2202 from Geobacter sulfurreducens PCA, are LysR family transcriptional regulators found regularly in the vicinity of multiheme cytochromes such as GSU2203, a decaheme c-type cytochrome.


Pssm-ID: 468965 [Multi-domain]  Cd Length: 301  Bit Score: 45.50  E-value: 1.85e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1539182854   9 LLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRErRKEIELTAAG 62
Cdd:NF041036    9 LVIVAEEGSFSKAAEKLHLTQSAVSQRIKFLEECYGYQLFDRS-GPSLEPTAAG 61
PRK10094 PRK10094
HTH-type transcriptional activator AllS;
6-62 2.03e-07

HTH-type transcriptional activator AllS;


Pssm-ID: 182237 [Multi-domain]  Cd Length: 308  Bit Score: 45.18  E-value: 2.03e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1539182854   6 IHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRkEIELTAAG 62
Cdd:PRK10094    7 LRTFIAVAETGSFSKAAERLCKTTATISYRIKLLEENTGVALFFRTTR-SVTLTAAG 62
cbl PRK12679
HTH-type transcriptional regulator Cbl;
19-62 4.31e-06

HTH-type transcriptional regulator Cbl;


Pssm-ID: 183676 [Multi-domain]  Cd Length: 316  Bit Score: 41.72  E-value: 4.31e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1539182854  19 TEASKRLYMTQSAVSQAISALEEELGVDILIRERRKEIELTAAG 62
Cdd:PRK12679   20 TEVANMLFTSQSGVSRHIRELEDELGIEIFIRRGKRLLGMTEPG 63
PRK12680 PRK12680
LysR family transcriptional regulator;
1-62 6.29e-06

LysR family transcriptional regulator;


Pssm-ID: 183677 [Multi-domain]  Cd Length: 327  Bit Score: 41.15  E-value: 6.29e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1539182854   1 MTLTQIHALLAVLEYG-GFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKEIELTAAG 62
Cdd:PRK12680    1 MTLTQLRYLVAIADAElNITLAAARVHATQPGLSKQLKQLEDELGFLLFVRKGRSLESVTPAG 63
PRK09791 PRK09791
LysR family transcriptional regulator;
3-62 8.09e-06

LysR family transcriptional regulator;


Pssm-ID: 182077 [Multi-domain]  Cd Length: 302  Bit Score: 40.90  E-value: 8.09e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539182854   3 LTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIReRRKEIELTAAG 62
Cdd:PRK09791    7 IHQIRAFVEVARQGSIRGASRMLNMSQPALTKSIQELEEGLAAQLFFR-RSKGVTLTDAG 65
PRK09986 PRK09986
LysR family transcriptional regulator;
10-62 3.16e-05

LysR family transcriptional regulator;


Pssm-ID: 182183 [Multi-domain]  Cd Length: 294  Bit Score: 38.94  E-value: 3.16e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1539182854  10 LAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKeIELTAAG 62
Cdd:PRK09986   16 LAVAEELHFGRAAARLNISQPPLSIHIKELEDQLGTPLFIRHSRS-VVLTHAG 67
PRK10341 PRK10341
transcriptional regulator TdcA;
10-62 3.61e-05

transcriptional regulator TdcA;


Pssm-ID: 182391 [Multi-domain]  Cd Length: 312  Bit Score: 39.08  E-value: 3.61e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1539182854  10 LAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIReRRKEIELTAAG 62
Cdd:PRK10341   16 QEVIRSGSIGSAAKELGLTQPAVSKIINDIEDYFGVELIVR-KNTGVTLTPAG 67
PRK14997 PRK14997
LysR family transcriptional regulator; Provisional
 12-54 1.21e-04

LysR family transcriptional regulator; Provisional


Pssm-ID: 184959 [Multi-domain]  Cd Length: 301  Bit Score: 37.66  E-value: 1.21e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1539182854  12 VLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRK 54
Cdd:PRK14997   13 VVEEGGFAAAGRALDEPKSKLSRRIAQLEERLGVRLIQRTTRQ 55
PRK11716 PRK11716
HTH-type transcriptional activator IlvY;
26-62 1.23e-03

HTH-type transcriptional activator IlvY;


Pssm-ID: 236961 [Multi-domain]  Cd Length: 269  Bit Score: 34.41  E-value: 1.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1539182854  26 YMTQSAVSQAISALEEELGVDILIRERRKeIELTAAG 62
Cdd:PRK11716    2 HVSPSTLSRQIQRLEEELGQPLFVRDNRS-VTLTEAG 37
PRK15421 PRK15421
HTH-type transcriptional regulator MetR;
3-51 1.95e-03

HTH-type transcriptional regulator MetR;


Pssm-ID: 185319 [Multi-domain]  Cd Length: 317  Bit Score: 34.22  E-value: 1.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1539182854   3 LTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRE 51
Cdd:PRK15421    4 VKHLKTLQALRNCGSLAAAAATLHQTQSALSHQFSDLEQRLGFRLFVRK 52
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 1-41 2.42e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 32.18  E-value: 2.42e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 1539182854  1 MTLTQIHALLAVLEYGGFT--EASKRLYMTQSAVSQAISALEE 41
Cdd:pfam12802  3 LTPAQFRVLLALARNPGLTvaELARRLGISKQTVSRLVKRLEA 45
PRK15243 PRK15243
virulence genes transcriptional activator SpvR;
5-51 2.63e-03

virulence genes transcriptional activator SpvR;


Pssm-ID: 185155 [Multi-domain]  Cd Length: 297  Bit Score: 33.87  E-value: 2.63e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1539182854   5 QIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRE 51
Cdd:PRK15243    8 KLKIFITLMETGSFSIATSVLYITRTPLSRVISDLERELKQRLFIRK 54
PRK11151 PRK11151
DNA-binding transcriptional regulator OxyR; Provisional
 1-62 3.26e-03

DNA-binding transcriptional regulator OxyR; Provisional


Pssm-ID: 182999 [Multi-domain]  Cd Length: 305  Bit Score: 33.46  E-value: 3.26e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539182854   1 MTLTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERRKEIeLTAAG 62
Cdd:PRK11151    1 MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVL-FTQAG 61
cysB PRK12681
HTH-type transcriptional regulator CysB;
19-62 3.35e-03

HTH-type transcriptional regulator CysB;


Pssm-ID: 183678 [Multi-domain]  Cd Length: 324  Bit Score: 33.33  E-value: 3.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1539182854  19 TEASKRLYMTQSAVSQAISALEEELGVDILIRERRKEIELTAAG 62
Cdd:PRK12681   20 SATAEGLYTSQPGISKQVRMLEDELGIQIFARSGKHLTQVTPAG 63
PRK11233 PRK11233
nitrogen assimilation transcriptional regulator; Provisional
 1-53 3.37e-03

nitrogen assimilation transcriptional regulator; Provisional


Pssm-ID: 183045 [Multi-domain]  Cd Length: 305  Bit Score: 33.50  E-value: 3.37e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1539182854   1 MTLTQIHALLAVLEYGGFTEASKRLYMTQSAVSQAISALEEELGVDILIRERR 53
Cdd:PRK11233    1 MNFRRLKYFVKIVDIGSLTQAAEVLHIAQPALSQQVATLEGELNQQLLIRTKR 53
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-62 3.86e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 33.02  E-value: 3.86e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539182854   1 MTLTQIHALLAVLEYGG--FTEASKRLYMTQSAVSQAISALEEElgvDILIRE------RRKEIELTAAG 62
Cdd:COG1846    36 LTPAQFRVLAALAEAGGltQSELAERLGLTKSTVSRLLDRLEEK---GLVEREpdpedrRAVLVRLTEKG 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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