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Conserved domains on  [gi|1578749287|emb|VFD64404|]
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two-component sensor histidine kinase [Clostridioides difficile]

Protein Classification

sensor histidine kinase( domain architecture ID 11711987)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; contains an N-terminal 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules) transmembrane region

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
403-653 2.55e-59

Sensor histidine kinase WalK [Signal transduction mechanisms];


:

Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 204.02  E-value: 2.55e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 403 NRNRIIIKENEKLTRNLEHEVEVRTNELTTLLNERKRFLADVAHDLKAPVSAIQAFIDLIKVGNIHVDEETRTYLYAINQ 482
Cdd:COG5002   131 LGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILE 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 483 KSNEVQNRVRSLQEFTSQD-KSIGIS-EKICLNNFIKEIYENNLPDTQACGVNFETYVLEKKIYAKINKEMLTRAFENLI 560
Cdd:COG5002   211 EAERLSRLVNDLLDLSRLEsGELKLEkEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLL 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 561 YNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFT--ERDNNEPKGQGLGLYIVKSIIREHGGEIF 638
Cdd:COG5002   291 DNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRvdKSRSRETGGTGLGLAIVKHIVEAHGGRIW 370

                         250
                  ....*....|....*
gi 1578749287 639 VDSELGKGTVFTIKL 653
Cdd:COG5002   371 VESEPGKGTTFTITL 385
7TMR-DISM_7TM super family cl21630
7TM diverse intracellular signalling; This entry represents the transmembrane region of the ...
 194-404 9.07e-04

7TM diverse intracellular signalling; This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).


The actual alignment was detected with superfamily member pfam07695:

Pssm-ID: 429600 [Multi-domain]  Cd Length: 207  Bit Score: 41.11  E-value: 9.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 194 RLLFYSIICFTTFAIAIFSLSVWFlSNKSKIYLYFGCMCVFFAIHVSYPFVHLLGLPLVSFTYAVEDLSYFMVVLCIICI 273
Cdd:pfam07695   1 ENLLLGLFYGILLALALYNLFLFF-SLRDRSYLYYVLYLLSFLLYQLSLNGLGFQYLWPNAPPWLNNKLLYLSLLLLLPF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 274 NGSI-------SKIEENKVYRFLILPLGItmsiisivIPIILLPYDMYFVNIYGKLIDIYKYIVFIYILMSSLVSIYKKt 346
Cdd:pfam07695  80 FALLfarsfleLKKYLPRLLRLLLGLALL--------LALLLLLLPLFPYTLSLPLAQLLALLFILFLLLLGIIAWRKG- 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 347 csEHISSYILVSVnTVFGISILFDAVTSNRFEP--IFTGWQTEYCGFVIVILFSVMMINR 404
Cdd:pfam07695 151 --YKPARYFLLAW-LLLLIGALIDILSLLGLLPsnFFTNYLLQIGSALEVLLLSLALADR 207
 
Name Accession Description Interval E-value
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
403-653 2.55e-59

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 204.02  E-value: 2.55e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 403 NRNRIIIKENEKLTRNLEHEVEVRTNELTTLLNERKRFLADVAHDLKAPVSAIQAFIDLIKVGNIHVDEETRTYLYAINQ 482
Cdd:COG5002   131 LGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILE 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 483 KSNEVQNRVRSLQEFTSQD-KSIGIS-EKICLNNFIKEIYENNLPDTQACGVNFETYVLEKKIYAKINKEMLTRAFENLI 560
Cdd:COG5002   211 EAERLSRLVNDLLDLSRLEsGELKLEkEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLL 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 561 YNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFT--ERDNNEPKGQGLGLYIVKSIIREHGGEIF 638
Cdd:COG5002   291 DNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRvdKSRSRETGGTGLGLAIVKHIVEAHGGRIW 370

                         250
                  ....*....|....*
gi 1578749287 639 VDSELGKGTVFTIKL 653
Cdd:COG5002   371 VESEPGKGTTFTITL 385
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 552-653 1.85e-36

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 131.96  E-value: 1.85e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNEPKGQGLGLYIVKSIIR 631
Cdd:cd00075     1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80

                          90       100
                  ....*....|....*....|..
gi 1578749287 632 EHGGEIFVDSELGKGTVFTIKL 653
Cdd:cd00075    81 AHGGRITVESEPGGGTTFTVTL 102
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 547-656 9.99e-35

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 127.38  E-value: 9.99e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287  547 INKEMLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNN-EPKGQGLGLYI 625
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrKIGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1578749287  626 VKSIIREHGGEIFVDSELGKGTVFTIKLSLC 656
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
415-653 1.71e-33

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 135.87  E-value: 1.71e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 415 LTRNLEHEVEV-RTNELTTLlnerKRFLADVAHDLKAPVSAIQAFIDLIKVGNihVDEETRTYLYAINQKSNEVQNRVRS 493
Cdd:PRK11360  371 LTERKRLQRRVaRQERLAAL----GELVAGVAHEIRNPLTAIRGYVQIWRQQT--SDPPSQEYLSVVLREVDRLNKVIDQ 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 494 LQEFTSQDKSIgiSEKICLNNFIKEIYENNLPDTQACGVNFETyVLEKKIYA-KINKEMLTRAFENLIYNALTFTPFDGK 572
Cdd:PRK11360  445 LLEFSRPRESQ--WQPVSLNALVEEVLQLFQTAGVQARVDFET-ELDNELPPiWADPELLKQVLLNILINAVQAISARGK 521

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 573 IILSMDKE-DGFAIIKISDNGKGIPPENIPKVFDRFFTERdnnePKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTI 651
Cdd:PRK11360  522 IRIRTWQYsDGQVAVSIEDNGCGIDPELLKKIFDPFFTTK----AKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTL 597


                  ..
gi 1578749287 652 KL 653
Cdd:PRK11360  598 YL 599
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 552-655 2.07e-29

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 112.46  E-value: 2.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNALTFTPFDGKIILSMDKEDGFaIIKISDNGKGIPPENIPKVFDRFFTeRDNNEPKGQGLGLYIVKSIIR 631
Cdd:pfam02518   6 LRQVLSNLLDNALKHAAKAGEITVTLSEGGEL-TLTVEDNGIGIPPEDLPRIFEPFST-ADKRGGGGTGLGLSIVRKLVE 83

                          90       100
                  ....*....|....*....|....
gi 1578749287 632 EHGGEIFVDSELGKGTVFTIKLSL 655
Cdd:pfam02518  84 LLGGTITVESEPGGGTTVTLTLPL 107
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 439-653 5.09e-25

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 108.63  E-value: 5.09e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 439 RFLADVAHDLKAPVSAI--QAFIDLIKvgnihvdEETRTYLYAINQKSNEVQNRVRSLQE---FTSQ-DKSIGISEKICL 512
Cdd:TIGR01386 243 QFSADLAHELRTPLTNLlgQTQVALSQ-------PRTGEEYREVLESNLEELERLSRMVSdmlFLARaDNGQLALERVRL 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 513 -----NNFIKEIYENNLPDTqacGVnfeTYVLEKKIYAKINKEMLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIK 587
Cdd:TIGR01386 316 dlaaeLAKVAEYFEPLAEER---GV---RIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVS 389

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1578749287 588 ISDNGKGIPPENIPKVFDRFF---TERDNNEpKGQGLGLYIVKSIIREHGGEIFVDSELGKgTVFTIKL 653
Cdd:TIGR01386 390 VSNPGPGIPPEHLSRLFDRFYrvdPARSNSG-EGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRF 456
7TMR-DISM_7TM pfam07695
7TM diverse intracellular signalling; This entry represents the transmembrane region of the ...
 194-404 9.07e-04

7TM diverse intracellular signalling; This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).


Pssm-ID: 429600 [Multi-domain]  Cd Length: 207  Bit Score: 41.11  E-value: 9.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 194 RLLFYSIICFTTFAIAIFSLSVWFlSNKSKIYLYFGCMCVFFAIHVSYPFVHLLGLPLVSFTYAVEDLSYFMVVLCIICI 273
Cdd:pfam07695   1 ENLLLGLFYGILLALALYNLFLFF-SLRDRSYLYYVLYLLSFLLYQLSLNGLGFQYLWPNAPPWLNNKLLYLSLLLLLPF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 274 NGSI-------SKIEENKVYRFLILPLGItmsiisivIPIILLPYDMYFVNIYGKLIDIYKYIVFIYILMSSLVSIYKKt 346
Cdd:pfam07695  80 FALLfarsfleLKKYLPRLLRLLLGLALL--------LALLLLLLPLFPYTLSLPLAQLLALLFILFLLLLGIIAWRKG- 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 347 csEHISSYILVSVnTVFGISILFDAVTSNRFEP--IFTGWQTEYCGFVIVILFSVMMINR 404
Cdd:pfam07695 151 --YKPARYFLLAW-LLLLIGALIDILSLLGLLPsnFFTNYLLQIGSALEVLLLSLALADR 207
 
Name Accession Description Interval E-value
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
403-653 2.55e-59

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 204.02  E-value: 2.55e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 403 NRNRIIIKENEKLTRNLEHEVEVRTNELTTLLNERKRFLADVAHDLKAPVSAIQAFIDLIKVGNIHVDEETRTYLYAINQ 482
Cdd:COG5002   131 LGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILE 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 483 KSNEVQNRVRSLQEFTSQD-KSIGIS-EKICLNNFIKEIYENNLPDTQACGVNFETYVLEKKIYAKINKEMLTRAFENLI 560
Cdd:COG5002   211 EAERLSRLVNDLLDLSRLEsGELKLEkEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLL 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 561 YNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFT--ERDNNEPKGQGLGLYIVKSIIREHGGEIF 638
Cdd:COG5002   291 DNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRvdKSRSRETGGTGLGLAIVKHIVEAHGGRIW 370

                         250
                  ....*....|....*
gi 1578749287 639 VDSELGKGTVFTIKL 653
Cdd:COG5002   371 VESEPGKGTTFTITL 385
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
422-653 9.42e-58

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 194.74  E-value: 9.42e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 422 EVEVRTNELTTLLNERKRFLADVAHDLKAPVSAIQAFIDLIKVGNIHVDEETRTYLYAINQKSNEVQNRVRSLQEFtSQD 501
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDL-SRL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 502 KSIGIS---EKICLNNFIKEIYENNLPDTQACGVNFETYVLEKKIYAKINKEMLTRAFENLIYNALTFTPFDGKIILSMD 578
Cdd:COG2205    80 ESGKLSlelEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISAR 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1578749287 579 KEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNEPKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:COG2205   160 REGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
434-653 1.44e-56

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 194.74  E-value: 1.44e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 434 LNERK-RFLADVAHDLKAPVSAIQAFIDLIKvgnIHVDEETRTYLYAINQKSNEVQNRVRSLQEFTSQDKSIGI--SEKI 510
Cdd:COG0642   106 ANEAKsRFLANVSHELRTPLTAIRGYLELLL---EELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLElePEPV 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 511 CLNNFIKEIYENNLPDTQACGVNFETYVLEKKIYAKINKEMLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISD 590
Cdd:COG0642   183 DLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVED 262

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1578749287 591 NGKGIPPENIPKVFDRFFTERDNNEPKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:COG0642   263 TGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 390-653 1.64e-42

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 160.72  E-value: 1.64e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 390 GFVIVILFSVMMINRNRIIIKENEKLTRNLEHEVEVRTNELTTLLNERKRFLADVAHDLKAPVSAIQAFIDLIKVGNIHV 469
Cdd:COG4251   235 LVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDK 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 470 -DEETRTYLYAINQKSNEVQNRVRSLQEFTSQDKSIGISEKICLNNFIKEIYENNLPDTQACGVNFETYVLEKkIYAkiN 548
Cdd:COG4251   315 lDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPT-VRG--D 391

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 549 KEMLTRAFENLIYNALTFTPFD--GKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNEPKGQGLGLYIV 626
Cdd:COG4251   392 PTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIV 471

                         250       260
                  ....*....|....*....|....*..
gi 1578749287 627 KSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:COG4251   472 KKIVERHGGRIWVESEPGEGATFYFTL 498
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 424-655 1.49e-40

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 153.58  E-value: 1.49e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 424 EVRTNELTTLlnerKRFLADVAHDLKAPVSAIQAFIDLIKV---GNIHVDEETRT-YLYAINQKSNEVQNRVRSLQEFTS 499
Cdd:COG5000   192 LLRAERLAAW----GELARRIAHEIKNPLTPIQLSAERLRRklaDKLEEDREDLErALDTIIRQVDRLKRIVDEFLDFAR 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 500 QDKSIgiSEKICLNNFIKEI---YENNLpdtQACGVNFETYVLEKKIYAKINKEMLTRAFENLIYNALTFTPFDGKIILS 576
Cdd:COG5000   268 LPEPQ--LEPVDLNELLREVlalYEPAL---KEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVS 342

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1578749287 577 MDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERdnnePKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKLSL 655
Cdd:COG5000   343 TRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTK----PKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 367-653 1.19e-36

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 140.70  E-value: 1.19e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 367 ILFDAVTSNRFEPIFTGWQTEYCGFVIVILFSVMMINRNRIIIKENEKLTRNLEhEVEVRTNELTTLLNERKR------- 439
Cdd:COG4191    57 LLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELE-ELERDITELERAEEELRElqeqlvq 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 440 ---------FLADVAHDLKAPVSAIQAFIDLIK--VGNIHVDEETRTYLYAINQKSNEVQNRVRSLQEFTSQDKSIgiSE 508
Cdd:COG4191   136 seklaalgeLAAGIAHEINNPLAAILGNAELLRrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEE--RE 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 509 KICLNNFIKEIYENNLPDTQACGVNFETYVLEKKIYAKINKEMLTRAFENLIYNAL--TFTPFDGKIILSMDKEDGFAII 586
Cdd:COG4191   214 PVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIdaMEEGEGGRITISTRREGDYVVI 293

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1578749287 587 KISDNGKGIPPENIPKVFDRFFTERDnnEPKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:COG4191   294 SVRDNGPGIPPEVLERIFEPFFTTKP--VGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 552-653 1.85e-36

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 131.96  E-value: 1.85e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNEPKGQGLGLYIVKSIIR 631
Cdd:cd00075     1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80

                          90       100
                  ....*....|....*....|..
gi 1578749287 632 EHGGEIFVDSELGKGTVFTIKL 653
Cdd:cd00075    81 AHGGRITVESEPGGGTTFTVTL 102
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 547-656 9.99e-35

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 127.38  E-value: 9.99e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287  547 INKEMLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNN-EPKGQGLGLYI 625
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrKIGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1578749287  626 VKSIIREHGGEIFVDSELGKGTVFTIKLSLC 656
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
415-653 1.71e-33

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 135.87  E-value: 1.71e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 415 LTRNLEHEVEV-RTNELTTLlnerKRFLADVAHDLKAPVSAIQAFIDLIKVGNihVDEETRTYLYAINQKSNEVQNRVRS 493
Cdd:PRK11360  371 LTERKRLQRRVaRQERLAAL----GELVAGVAHEIRNPLTAIRGYVQIWRQQT--SDPPSQEYLSVVLREVDRLNKVIDQ 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 494 LQEFTSQDKSIgiSEKICLNNFIKEIYENNLPDTQACGVNFETyVLEKKIYA-KINKEMLTRAFENLIYNALTFTPFDGK 572
Cdd:PRK11360  445 LLEFSRPRESQ--WQPVSLNALVEEVLQLFQTAGVQARVDFET-ELDNELPPiWADPELLKQVLLNILINAVQAISARGK 521

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 573 IILSMDKE-DGFAIIKISDNGKGIPPENIPKVFDRFFTERdnnePKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTI 651
Cdd:PRK11360  522 IRIRTWQYsDGQVAVSIEDNGCGIDPELLKKIFDPFFTTK----AKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTL 597


                  ..
gi 1578749287 652 KL 653
Cdd:PRK11360  598 YL 599
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 391-655 3.28e-31

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 127.17  E-value: 3.28e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 391 FVIVILFSVMMINRNRIIIKENEKLTRNLEHEVEVRTnelttllnerkRFLADVAHDLKAPVSAIQAFIDLIKVGniHVD 470
Cdd:COG5808   206 VLISIIFLLLQYNLLKRKTLLERVIQEINTQKLELIG-----------TFAASTAHEIRNPLTSIKGFIQLLQEK--YPE 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 471 EETRTYLYAINQKSNEVQNRVrslQEFTSQDKSIGISEKIC-LNNFIKEIYENNLPDTQACGVNFETYVLEKKIYAKINK 549
Cdd:COG5808   273 LEDQKYFDIIQEEIQRINQIV---SEFLVLGKPTAKKLELDdLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDK 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 550 EMLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNnepkGQGLGLYIVKSI 629
Cdd:COG5808   350 DRIKQVLLNLIKNAIEAMKEGGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEG----GTGLGLSVCKRI 425

                         250       260
                  ....*....|....*....|....*.
gi 1578749287 630 IREHGGEIFVDSELGKGTVFTIKLSL 655
Cdd:COG5808   426 VEMHGGEIDIESEEGKGTTFTIRLPL 451
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
444-653 8.80e-31

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 123.80  E-value: 8.80e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 444 VAHDLKAPVSAIQAFIDLIKvGNIHvDEETRTYLYAINQKSNEVQNRVRSLQEFtsQDKSIGISEKICLNNFIKEIYENN 523
Cdd:COG3852   142 LAHEIRNPLTGIRGAAQLLE-RELP-DDELREYTQLIIEEADRLNNLVDRLLSF--SRPRPPEREPVNLHEVLERVLELL 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 524 LPDTQAcGVNFETYVLEKKIYAKINKEMLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAI----------IKISDNGK 593
Cdd:COG3852   218 RAEAPK-NIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTLgglrprlyvrIEVIDNGP 296

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 594 GIPPENIPKVFDRFFTERDNnepkGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:COG3852   297 GIPEEILDRIFEPFFTTKEK----GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 552-655 2.07e-29

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 112.46  E-value: 2.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNALTFTPFDGKIILSMDKEDGFaIIKISDNGKGIPPENIPKVFDRFFTeRDNNEPKGQGLGLYIVKSIIR 631
Cdd:pfam02518   6 LRQVLSNLLDNALKHAAKAGEITVTLSEGGEL-TLTVEDNGIGIPPEDLPRIFEPFST-ADKRGGGGTGLGLSIVRKLVE 83

                          90       100
                  ....*....|....*....|....
gi 1578749287 632 EHGGEIFVDSELGKGTVFTIKLSL 655
Cdd:pfam02518  84 LLGGTITVESEPGGGTTVTLTLPL 107
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 390-653 8.16e-28

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 117.38  E-value: 8.16e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 390 GFVIVILFSVMMINRNR------IIIKEnekLTRNLEHEVEVRTNELTTLLNErkrFLADVAHDLKAPVSAIQAFIDLIK 463
Cdd:COG5809   223 GRWRLLEASGAPIKKNGevdgivIIFRD---ITERKKLEELLRKSEKLSVVGE---LAAGIAHEIRNPLTSLKGFIQLLK 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 464 vGNIHvdEETRTYLYAINQKSNevqnRVRS-LQEFTSQDKSIGIS-EKICLNNFIKEIYEnnLPDTQAC--GVNFETYVL 539
Cdd:COG5809   297 -DTID--EEQKTYLDIMLSELD----RIESiISEFLVLAKPQAIKyEPKDLNTLIEEVIP--LLQPQALlkNVQIELELE 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 540 EKKIYAKINKEMLTRAFENLIYNALTFTPFDGKIILSM-DKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDnnepKG 618
Cdd:COG5809   368 DDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETkAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKE----KG 443

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1578749287 619 QGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:COG5809   444 TGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 445-657 3.36e-25

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 109.55  E-value: 3.36e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 445 AHDLKAPVSAIQAFIDLIkvgNIHVDEETRTYLYA-INQKSNEVQNRVRSLQEFTS--QDKSIGISEKICLNNFIKEIYE 521
Cdd:PRK11100  264 THELKSPLAAIRGAAELL---QEDPPPEDRARFTGnILTQSARLQQLIDRLLELARleQRQELEVLEPVALAALLEELVE 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 522 NNLPDTQACGVNFETYVLEKKIYAkiNKEMLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIP 601
Cdd:PRK11100  341 AREAQAAAKGITLRLRPDDARVLG--DPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALP 418

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1578749287 602 KVFDRFF-TERDNNEPKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKLSLCF 657
Cdd:PRK11100  419 RIFERFYsLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 439-653 5.09e-25

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 108.63  E-value: 5.09e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 439 RFLADVAHDLKAPVSAI--QAFIDLIKvgnihvdEETRTYLYAINQKSNEVQNRVRSLQE---FTSQ-DKSIGISEKICL 512
Cdd:TIGR01386 243 QFSADLAHELRTPLTNLlgQTQVALSQ-------PRTGEEYREVLESNLEELERLSRMVSdmlFLARaDNGQLALERVRL 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 513 -----NNFIKEIYENNLPDTqacGVnfeTYVLEKKIYAKINKEMLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIK 587
Cdd:TIGR01386 316 dlaaeLAKVAEYFEPLAEER---GV---RIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVS 389

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1578749287 588 ISDNGKGIPPENIPKVFDRFF---TERDNNEpKGQGLGLYIVKSIIREHGGEIFVDSELGKgTVFTIKL 653
Cdd:TIGR01386 390 VSNPGPGIPPEHLSRLFDRFYrvdPARSNSG-EGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRF 456
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 271-653 1.30e-22

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 100.31  E-value: 1.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 271 ICINGSISKIEENKVYRFLILPLGITMSIISIVIPIILLPYDMYFVNIYGKLIDIYkYIVFIYILMSSLVSIYKKTCSEH 350
Cdd:COG3290     1 LLLLLLLLLLLLILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLIL-LLILLLLLLLLLAALLLKLLEEI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 351 ISSY-----ILVSVN--------------------TVFGISILFDAVTSNRFEPIFTGWQTEycgfVIVILFSVMMINRN 405
Cdd:COG3290    80 ARLVeereaVLESIRegviavdrdgritlindaarRLLGLDAIGRPIDEVLAEVLETGERDE----EILLNGRVLVVNRV 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 406 RIIIKENEK---LTRNLEHEVEVRTNELTTLLNerkrfLADV----AHDLKAPVSAIQAFIDLIKvgnihvDEETRTYLY 478
Cdd:COG3290   156 PIRDDGRVVgavATFRDRTELERLEEELEGVKE-----LAEAlraqRHDFRNHLHTISGLLQLGE------YDEALEYID 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 479 AInqkSNEVQNRVRSLQEFTsqdKSIGISekICLNNFIKEIYENnlpdtqacGVNFETYVLEKKIYAKINKEMLTRAFEN 558
Cdd:COG3290   225 EI---SEELQELIDSLLSRI---GNPVLA--ALLLGKAARARER--------GIDLTIDIDSDLPDLPLSDTDLVTILGN 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 559 LIYNAL----TFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNnepKGQGLGLYIVKSIIREHG 634
Cdd:COG3290   289 LLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLG---EGRGLGLALVKQIVEKYG 365

                         410
                  ....*....|....*....
gi 1578749287 635 GEIFVDSELGKGTVFTIKL 653
Cdd:COG3290   366 GTIEVESEEGEGTVFTVRL 384
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 555-651 1.52e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 92.73  E-value: 1.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 555 AFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFT-ERDNNEPKGQGLGLYIVKSIIREH 633
Cdd:cd16948     9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTgENGRNFQESTGMGLYLVKKLCDKL 88

                          90
                  ....*....|....*...
gi 1578749287 634 GGEIFVDSELGKGTVFTI 651
Cdd:cd16948    89 GHKIDVESEVGEGTTFTI 106
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 552-653 2.13e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 92.64  E-value: 2.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNALTFTPFD-GKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNEPKGQ--GLGLYIVKS 628
Cdd:cd16953     1 LGQVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQhsGLGLSISRQ 80

                          90       100
                  ....*....|....*....|....*....
gi 1578749287 629 IIREHGG----EIFVDSELGKGTVFTIKL 653
Cdd:cd16953    81 IIEAHGGisvaENHNQPGQVIGARFTVQL 109
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 550-655 9.32e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 90.56  E-value: 9.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 550 EMLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNEpkGQGLGLYIVKSI 629
Cdd:cd16943     2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE--GTGLGLSLSYRI 79

                          90       100
                  ....*....|....*....|....*.
gi 1578749287 630 IREHGGEIFVDSELGKGTVFTIKLSL 655
Cdd:cd16943    80 IQKHGGTIRVASVPGGGTRFTIILPI 105
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 442-655 1.98e-21

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 98.27  E-value: 1.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 442 ADVAHDLKAPVSAIQAFIDLIKVG--------NIHVDEETRtylyaINQKSNEVQnrvrslqeFTSQDKSIGIsEKICLN 513
Cdd:COG5805   292 AGIAHEIRNPLTSIKGFLQLLQPGiedkeeyfDIMLSELDR-----IESIISEFL--------ALAKPQAVNK-EKENIN 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 514 NFIKEIYenNLPDTQAC--GVNFETYVLEKKIYAKINKEMLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDN 591
Cdd:COG5805   358 ELIQDVV--TLLETEAIlhNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDE 435

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1578749287 592 GKGIPPENIPKVFDRFFTERDnnepKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKLSL 655
Cdd:COG5805   436 GIGIPEERLKKLGEPFFTTKE----KGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 558-653 2.25e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 86.57  E-value: 2.25e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 558 NLI---YNALTFTPFDGKII-LSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERdnnEPKGQGLGLYIVKSIIREH 633
Cdd:cd16915     7 NLIdnaLDALAATGAPNKQVeVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTK---GQGERGIGLALVRQSVERL 83

                          90       100
                  ....*....|....*....|
gi 1578749287 634 GGEIFVDSELGKGTVFTIKL 653
Cdd:cd16915    84 GGSITVESEPGGGTTFSIRI 103
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 552-650 2.61e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 86.49  E-value: 2.61e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFF---TERDNNEpKGQGLGLYIVKS 628
Cdd:cd16952     1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYrvdIERCRNT-GGTGLGLAIVKH 79

                          90       100
                  ....*....|....*....|..
gi 1578749287 629 IIREHGGEIFVDSELGKGTVFT 650
Cdd:cd16952    80 VMSRHDARLLIASELGKGSRFT 101
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 533-653 6.28e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 86.03  E-value: 6.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 533 NFETYVLEKKIYAKINKEMLTRAFENLIYNALTFTPfDGKII-LSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTER 611
Cdd:cd16947     2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGS-DGKFLgMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1578749287 612 D--NNEPKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:cd16947    81 DsrNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
PRK09303 PRK09303
histidine kinase;
410-650 1.24e-19

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 91.17  E-value: 1.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 410 KENEKLTRNLEHevevrtnelttllneRKRFLADVAHDLKAPVSAIQAFIDLIKVGNIHVDEETRTYLyaINQKSNEVQN 489
Cdd:PRK09303  139 QENETLLEQLKF---------------KDRVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPAL--IEQLQDQARR 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 490 RVRS--------LQEFTSQDKSIGIS-EKICLNNFIKEIYENNLPDTQACGVNFETYVLEK--KIYAkiNKEMLTRAFEN 558
Cdd:PRK09303  202 QLEEierlitdlLEVGRTRWEALRFNpQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDlpSVYA--DQERIRQVLLN 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 559 LIYNALTFTPFDGKIILSM-DKEDGFAIIKISDNGKGIPPENIPKVF-DRFFTERDNNEPkGQGLGLYIVKSIIREHGGE 636
Cdd:PRK09303  280 LLDNAIKYTPEGGTITLSMlHRTTQKVQVSICDTGPGIPEEEQERIFeDRVRLPRDEGTE-GYGIGLSVCRRIVRVHYGQ 358

                         250
                  ....*....|....
gi 1578749287 637 IFVDSELGKGTVFT 650
Cdd:PRK09303  359 IWVDSEPGQGSCFH 372
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 551-653 2.29e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 83.99  E-value: 2.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 551 MLTRAFENLIYNALTFTPFDGKIILSMDKEDGfAIIKISDNGKGIPPENIPKVFDRFFTERDNNEPkGQGLGLYIVKSII 630
Cdd:cd16940    13 LLFLLLRNLVDNAVRYSPQGSRVEIKLSADDG-AVIRVEDNGPGIDEEELEALFERFYRSDGQNYG-GSGLGLSIVKRIV 90

                          90       100
                  ....*....|....*....|...
gi 1578749287 631 REHGGEIFVDSELGKGTVFTIKL 653
Cdd:cd16940    91 ELHGGQIFLGNAQGGGLEAWVRL 113
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 558-655 3.18e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 83.31  E-value: 3.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 558 NLIYNALTFTPfDGKIILS---MDKEDGFAIIKIS--DNGKGIPPENIPKVFDRFFTERDNNEPK--GQGLGLYIVKSII 630
Cdd:cd16922     7 NLLGNAIKFTE-EGEVTLRvslEEEEEDGVQLRFSveDTGIGIPEEQQARLFEPFSQADSSTTRKygGTGLGLAISKKLV 85

                          90       100
                  ....*....|....*....|....*
gi 1578749287 631 REHGGEIFVDSELGKGTVFTIKLSL 655
Cdd:cd16922    86 ELMGGDISVESEPGQGSTFTFTLPL 110
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 552-653 8.17e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 81.99  E-value: 8.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNALTFTPfdGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFF---TERDNNEPkGQGLGLYIVKS 628
Cdd:cd16949     1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdSARDRESG-GTGLGLAIAER 77

                          90       100
                  ....*....|....*....|....*
gi 1578749287 629 IIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:cd16949    78 AIEQHGGKIKASNRKPGGLRVRIWL 102
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
550-655 2.15e-18

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 88.30  E-value: 2.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 550 EMLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDnnepKGQGLGLYIVKSI 629
Cdd:PRK10364  347 DRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKA----EGTGLGLAVVHNI 422

                          90       100
                  ....*....|....*....|....*.
gi 1578749287 630 IREHGGEIFVDSELGKGTVFTIKLSL 655
Cdd:PRK10364  423 VEQHGGTIQVASQEGKGATFTLWLPV 448
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 558-653 3.34e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 80.19  E-value: 3.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 558 NLIYNALTFTPF--DGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNepKGQGLGLYIVKSIIREHGG 635
Cdd:cd16976     7 NLLQNALDAMGKveNPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVG--KGTGLGLSISYGIVEEHGG 84

                          90
                  ....*....|....*...
gi 1578749287 636 EIFVDSELGKGTVFTIKL 653
Cdd:cd16976    85 RLSVANEEGAGARFTFDL 102
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 551-637 9.95e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 79.04  E-value: 9.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 551 MLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFT-ERDNNEPKGQGLGLYIVKSI 629
Cdd:cd16945     4 LLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlPRPHSGQKSTGLGLAFVQEV 83


                  ....*...
gi 1578749287 630 IREHGGEI 637
Cdd:cd16945    84 AQLHGGRI 91
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
440-653 3.36e-17

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 84.82  E-value: 3.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 440 FLADVAHDLKAPVSaiqafiDLIKVGNIhVDEETRTylyainqkSNEVQNRVRS-LQEFTSQDKSIgiSEKIclnnFIKE 518
Cdd:PRK09835  265 FSADIAHEIRTPIT------NLITQTEI-ALSQSRS--------QKELEDVLYSnLEELTRMAKMV--SDML----FLAQ 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 519 IYENNL-PDTQACGVN---------FETYVLEKKIYAKINKE---------MLTRAFENLIYNALTFTPFDGKIILSMDK 579
Cdd:PRK09835  324 ADNNQLiPEKKMLDLAdevgkvfdfFEAWAEERGVELRFVGDpcqvagdplMLRRAISNLLSNALRYTPAGEAITVRCQE 403

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1578749287 580 EDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNEPKGQ--GLGLYIVKSIIREHGGEIFVDSELgKGTVFTIKL 653
Cdd:PRK09835  404 VDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEgsGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISL 478
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 552-653 4.52e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 77.06  E-value: 4.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNAL-TFTPFDGKIILSMDKEDGFAI----------IKISDNGKGIPPENIPKVFDRFFTERDNnepkGQG 620
Cdd:cd16918     1 LIQVFLNLVRNAAqALAGSGGEIILRTRTQRQVTLghprhrlalrVSVIDNGPGIPPDLQDTIFYPMVSGREN----GTG 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1578749287 621 LGLYIVKSIIREHGGEIFVDSELGKgTVFTIKL 653
Cdd:cd16918    77 LGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSL 108
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 550-653 1.10e-16

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 75.99  E-value: 1.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 550 EMLTRAFENLIYNALTFTPFDGKIILSMDKED-GFAIIKISDNGKGIPPENIPKVFDRFFTERDNNEPK--GQGLGLYIV 626
Cdd:cd16925     3 EKYERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAhgGTGLGLSIV 82

                          90       100
                  ....*....|....*....|....*..
gi 1578749287 627 KSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:cd16925    83 KEFVELHGGTVTVSDAPGGGALFQVEL 109
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
429-653 1.50e-16

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 82.37  E-value: 1.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 429 ELTTLLNERKRFLADVAHDLKAPVSAIQAFIDLIKvgnihvDEETRTylyAINQKS----NEVQNRVRSLQEFTSQDKSI 504
Cdd:PRK11006  196 QMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQ------DQPLEG---ALREKAlhtmREQTQRMEGLVKQLLTLSKI 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 505 GISEKICLNNFIkeiyenNLP--------DTQACGVNFETYVLE--KKIYAKINKEMLTRAFENLIYNALTFTPFDGKII 574
Cdd:PRK11006  267 EAAPTIDLNEKV------DVPmmlrvlerEAQTLSQGKHTITFEvdNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHIT 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 575 LSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFF-----TERDNNepkGQGLGLYIVKSIIREHGGEIFVDSELGKGTVF 649
Cdd:PRK11006  341 VRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYrvdkaRSRQTG---GSGLGLAIVKHALSHHDSRLEIESEVGKGTRF 417


                  ....
gi 1578749287 650 TIKL 653
Cdd:PRK11006  418 SFVL 421
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 539-656 3.14e-16

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 81.45  E-value: 3.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 539 LEKKIYAKINKEMLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTerdnNEPKG 618
Cdd:COG5806   299 LEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFS----TKEKG 374

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1578749287 619 QGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKLSLC 656
Cdd:COG5806   375 TGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPLA 412
PRK15347 PRK15347
two component system sensor kinase;
558-655 2.22e-15

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 80.07  E-value: 2.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 558 NLIYNALTFTPfDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNepKGQGLGLYIVKSIIREHGGEI 637
Cdd:PRK15347  520 NLLGNAVKFTE-TGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHS--QGTGLGLTIASSLAKMMGGEL 596

                          90
                  ....*....|....*...
gi 1578749287 638 FVDSELGKGTVFTIKLSL 655
Cdd:PRK15347  597 TLFSTPGVGSCFSLVLPL 614
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
416-653 2.36e-15

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 80.16  E-value: 2.36e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287  416 TRNLEHEVEVRTNELTTLLNERKRFLADVAHDLKAPVSAIQAFIDLIKVGNIHVDE--ETRTYLYAINQKSNEVQNRVRS 493
Cdd:PRK09959   691 TRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQrvEAISLAYATGQSLLGLIGEILD 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287  494 LQEFTSQDKSI--------GISEKIClNNFIKEIYENNLpdTQACGVNFETYVLekkiyAKINKEMLTRAFENLIYNALT 565
Cdd:PRK09959   771 VDKIESGNYQLqpqwvdipTLVQNTC-HSFGAIAASKSI--ALSCSSTFPDHYL-----VKIDPQAFKQVLSNLLSNALK 842

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287  566 FTPFDG-KIILSM-DKEDGFAIIK--ISDNGKGIPPENIPKVFDRFFTERDNNEPKGQGLGLYIVKSIIREHGGEIFVDS 641
Cdd:PRK09959   843 FTTEGAvKITTSLgHIDDNHAVIKmtIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLES 922

                          250
                   ....*....|..
gi 1578749287  642 ELGKGTVFTIKL 653
Cdd:PRK09959   923 HPGIGTTFTITI 934
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 552-653 3.64e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 71.65  E-value: 3.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNEPKGQGLGLYIVKSIIR 631
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIE 80

                          90       100
                  ....*....|....*....|..
gi 1578749287 632 EHGGEIFVDSElGKGTVFTIKL 653
Cdd:cd16923    81 LHGGSASAEYD-DNHDLFKVRL 101
PRK10604 PRK10604
sensor protein RstB; Provisional
 551-644 5.98e-15

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 77.34  E-value: 5.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 551 MLTRAFENLIYNALTFTpfDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRF--FTERDNNEPKGQGLGLYIVKS 628
Cdd:PRK10604  319 LMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFvrLDPSRDRATGGCGLGLAIVHS 396

                          90
                  ....*....|....*..
gi 1578749287 629 IIREHGGEIFVD-SELG 644
Cdd:PRK10604  397 IALAMGGSVNCDeSELG 413
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
582-653 9.36e-15

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 77.80  E-value: 9.36e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1578749287 582 GFAIIKISDNGKGIPPENIPKVFDRFFTERdnnePKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:PRK13837  606 RYVLLRVSDTGAGIDEAVLPHIFEPFFTTR----AGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYL 673
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 558-653 2.47e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 69.35  E-value: 2.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 558 NLIYN---ALTFTPFDGKIIL--SMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERdnnePKGQGLGLYIVKSIIRE 632
Cdd:cd16920     7 NLVRNgieAMSEGGCERRELTirTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTK----SEGLGMGLSICRSIIEA 82

                          90       100
                  ....*....|....*....|.
gi 1578749287 633 HGGEIFVDSELGKGTVFTIKL 653
Cdd:cd16920    83 HGGRLSVESPAGGGATFQFTL 103
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 552-653 2.77e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 69.28  E-value: 2.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNALTFT-PFDGKII--LSMDKEDGFaIIKISDNGKGIPPENIPKVFDRFFTERDNNEPKGQGLGLYIVKS 628
Cdd:cd16921     1 LGQVLTNLLGNAIKFRrPRRPPRIevGAEDVGEEW-TFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRK 79

                          90       100
                  ....*....|....*....|....*
gi 1578749287 629 IIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:cd16921    80 IIERHGGRIWLESEPGEGTTFYFTL 104
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 583-653 6.73e-14

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 68.56  E-value: 6.73e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1578749287 583 FAIIKISDNGKGIPPENIPKVFDRFFTERDnnEPKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:cd16919    47 YVCLEVSDTGSGMPAEVLRRAFEPFFTTKE--VGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 558-653 7.30e-14

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 74.56  E-value: 7.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 558 NLIYNAL---TFTPfDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNepkgQGLGLYIVKSIIREHG 634
Cdd:PRK11086  440 NLIENALeavGGEE-GGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSN----RGVGLYLVKQSVENLG 514

                          90
                  ....*....|....*....
gi 1578749287 635 GEIFVDSELGKGTVFTIKL 653
Cdd:PRK11086  515 GSIAVESEPGVGTQFFVQI 533
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 552-653 1.33e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 67.18  E-value: 1.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNA------LTFTPFDGKIILSMDKEDGFAIIkISDNGKGIPPENIPKVFDRFFTERdnnePKGQGLGLYI 625
Cdd:cd16944     5 ISQVLTNILKNAaeaiegRPSDVGEVRIRVEADQDGRIVLI-VCDNGKGFPREMRHRATEPYVTTR----PKGTGLGLAI 79

                          90       100
                  ....*....|....*....|....*...
gi 1578749287 626 VKSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:cd16944    80 VKKIMEEHGGRISLSNREAGGACIRIIL 107
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 558-653 3.04e-13

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 73.05  E-value: 3.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 558 NLIYNALTFTPfDGKIILSMDKEDGFAI-IKISDNGKGIPPENIPKVFDRFF---TERDNNEPKGQGLGLYIVKSIIREH 633
Cdd:PRK11091  405 NLISNAVKFTQ-QGGVTVRVRYEEGDMLtFEVEDSGIGIPEDELDKIFAMYYqvkDSHGGKPATGTGIGLAVSKRLAQAM 483

                          90       100
                  ....*....|....*....|
gi 1578749287 634 GGEIFVDSELGKGTVFTIKL 653
Cdd:PRK11091  484 GGDITVTSEEGKGSCFTLTI 503
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 548-652 4.97e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 65.56  E-value: 4.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 548 NKEMLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNEPKGQ-GLGLYIV 626
Cdd:cd16975     1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHyGMGLYIA 80

                          90       100
                  ....*....|....*....|....*.
gi 1578749287 627 KSIIREHGGEIFVDSELGKGTVFTIK 652
Cdd:cd16975    81 KNLVEKHGGSLIIENSQKGGAEVTVK 106
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
548-655 1.68e-12

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 69.96  E-value: 1.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 548 NKEMLTRAFENLIYNALTFTpfDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFF---TERDNnEPKGQGLGLY 624
Cdd:PRK09470  350 NPNALASALENIVRNALRYS--HTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYrvdEARDR-ESGGTGLGLA 426

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1578749287 625 IVKSIIREHGGEIFV-DSELGkGTVFTIKLSL 655
Cdd:PRK09470  427 IVENAIQQHRGWVKAeDSPLG-GLRLTIWLPL 457
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 552-655 2.48e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 63.60  E-value: 2.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNALTFTpfDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFF---TERDNNEPkGQGLGLYIVKS 628
Cdd:cd16939     1 MARALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldPSRDRATG-GFGLGLAIVHR 77

                          90       100
                  ....*....|....*....|....*...
gi 1578749287 629 IIREHGGEIFV-DSELGkGTVFTIKLSL 655
Cdd:cd16939    78 VALWHGGHVECdDSELG-GACFRLTWPR 104
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 552-637 2.74e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 63.24  E-value: 2.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNALTFTpfDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNEPKGQGLGLYIVKSIIR 631
Cdd:cd16950     1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISD 78


                  ....*.
gi 1578749287 632 EHGGEI 637
Cdd:cd16950    79 AHGGSL 84
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 552-644 4.27e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 62.87  E-value: 4.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERD--NNEPKGQGLGLYIVKSI 629
Cdd:cd16946     5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESsrNRASGGSGLGLAICHNI 84

                          90
                  ....*....|....*.
gi 1578749287 630 IREHGGEIFVD-SELG 644
Cdd:cd16946    85 ALAHGGTISAEhSPLG 100
PRK10490 PRK10490
sensor protein KdpD; Provisional
 551-655 8.34e-12

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 68.52  E-value: 8.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 551 MLTRAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFftERDNNEPK--GQGLGLYIVKS 628
Cdd:PRK10490  778 LFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKF--ARGNKESAipGVGLGLAICRA 855

                          90       100
                  ....*....|....*....|....*..
gi 1578749287 629 IIREHGGEIFVDSELGKGTVFTIKLSL 655
Cdd:PRK10490  856 IVEVHGGTIWAENRPEGGACFRVTLPL 882
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 392-655 1.21e-11

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 67.62  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 392 VIVILFSVMMINRNRIIIKENEKLTRNLEHEVEVRTNELTTLLNERKRFLADVAHDLK---APVSAI---QAfidlikvG 465
Cdd:COG3920   250 LGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKELLLRELHHRVKnnlQVVSSLlrlQA-------R 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 466 NIHvDEETRTYLyainqksNEVQNRVRSL---QEFTSQDKSIgisEKICLNNFIKEIYENNLPDTQACGVNFETYVLEKK 542
Cdd:COG3920   323 RAD-DPEAREAL-------EESQNRIQALalvHELLYQSEDW---EGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVE 391

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 543 IYAK--------INkEMLTRAFEnliYNALTFTpfDGKIILSMDKEDGFAIIKISDNGKGIPPenipkvfdrffterDNN 614
Cdd:COG3920   392 LPADaavplgliLN-ELVTNALK---HAFLSGE--GGRIRVSWRREDGRLRLTVSDNGVGLPE--------------DVD 451

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1578749287 615 EPKGQGLGLYIVKSIIREHGGEIFVDSElgKGTVFTIKLSL 655
Cdd:COG3920   452 PPARKGLGLRLIRALVRQLGGTLELDRP--EGTRVRITFPL 490
PRK13557 PRK13557
histidine kinase; Provisional
 583-654 1.37e-11

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 67.39  E-value: 1.37e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1578749287 583 FAIIKISDNGKGIPPENIPKVFDRFFTERDnnEPKGQGLGLYIVKSIIREHGGEIFVDSELGKGTvfTIKLS 654
Cdd:PRK13557  324 YVSIAVTDTGSGMPPEILARVMDPFFTTKE--EGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGT--TVRLY 391
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
558-655 1.67e-11

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 67.69  E-value: 1.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 558 NLIYNALTFTPfDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFF-----TERDnnePKGQGLGLYIVKSIIRE 632
Cdd:PRK10841  569 NLLSNAIKFTD-TGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFqvgtgVQRN---FQGTGLGLAICEKLINM 644

                          90       100
                  ....*....|....*....|...
gi 1578749287 633 HGGEIFVDSELGKGTVFTIKLSL 655
Cdd:PRK10841  645 MDGDISVDSEPGMGSQFTIRIPL 667
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 571-653 6.28e-11

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 61.44  E-value: 6.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 571 GKIILSMDKEDGFAIIKISDNGKGIPPENI-PKVFDR------------------------FFTERDNNEPKGQGLGLYI 625
Cdd:cd16916    70 GTITLRAEHQGNQVVIEVSDDGRGIDREKIrEKAIERglitadeaatlsddevlnlifapgFSTAEQVTDVSGRGVGMDV 149

                          90       100
                  ....*....|....*....|....*...
gi 1578749287 626 VKSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:cd16916   150 VKRSIESLGGTIEVESEPGQGTTFTIRL 177
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
428-655 1.14e-10

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 64.27  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 428 NELTTLL--NE--RKRFLADVAHDLKAPVSAIQAFIDLIKVGNIHVDEETRTYLYAinqksnEVQNR---VRSLQEFTSQ 500
Cdd:PRK10549  227 NQLASTLekNEqmRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPESVASLQA------EVGTLtklVDDLHQLSLS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 501 DK--------SIGISE--KICLNNFiKEIYEN-------NLPDtqacgvnfetyvlEKKIYAkiNKEMLTRAFENLIYNA 563
Cdd:PRK10549  301 DEgalayrktPVDLVPllEVAGGAF-RERFASrgltlqlSLPD-------------SATVFG--DPDRLMQLFNNLLENS 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 564 LTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFF-TERDNNEPK-GQGLGLYIVKSIIREHGGEIFVD- 640
Cdd:PRK10549  365 LRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYrTEGSRNRASgGSGLGLAICLNIVEAHNGRIIAAh 444

                         250
                  ....*....|....*
gi 1578749287 641 SELGkGTVFTIKLSL 655
Cdd:PRK10549  445 SPFG-GVSITVELPL 458
envZ PRK09467
osmolarity sensor protein; Provisional
 554-644 3.40e-10

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 62.62  E-value: 3.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 554 RAFENLIYNALTFTPFDGKIILSMDKEdgFAIIKISDNGKGIPPENIPKVFDRfFTERD---NNEpkGQGLGLYIVKSII 630
Cdd:PRK09467  334 RALANLVVNAARYGNGWIKVSSGTEGK--RAWFQVEDDGPGIPPEQLKHLFQP-FTRGDsarGSS--GTGLGLAIVKRIV 408

                          90
                  ....*....|....*
gi 1578749287 631 REHGGEIFV-DSELG 644
Cdd:PRK09467  409 DQHNGKVELgNSEEG 423
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 558-644 1.19e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 56.87  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 558 NLIYNALTFTpfDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRffTERDNNEPKGQGLGLYIVKSIIREHGGEI 637
Cdd:cd16954    44 NLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQR--GQRLDEQRPGQGLGLAIAKEIVEQYGGEL 119


                  ....*...
gi 1578749287 638 -FVDSELG 644
Cdd:cd16954   120 sLSDSPLG 127
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 557-653 2.82e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 54.76  E-value: 2.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 557 ENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPkvfdrfftERDNNEPKGQGLGLYIVKSIIREHGGE 636
Cdd:cd16924    11 ENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLN--------ILGKKPKEGNGIGLYNVHQRLILLFGE 82

                          90       100
                  ....*....|....*....|
gi 1578749287 637 ---IFVDSELGKGTVFTIKL 653
Cdd:cd16924    83 dygIHIASEPDKGTRITFTI 102
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 412-653 3.86e-09

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 59.70  E-value: 3.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 412 NEKlTRNLEHEVEVR---TNELTTLLNERKRF--LADV-------AHDLKAPVSAIQAFIDLIKVGNIHV-DEETRTYLY 478
Cdd:COG4192   397 IEK-TQELETEIEERkriEKNLRQTQDELIQAakMAVVgqtmtslAHELNQPLNAMSMYLFSAKKALEQEnYAQLPTSLD 475

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 479 AINQKSNEVQNRVRSLQEFTSQD----KSIGISEKIclnNFIKEIYENNLPDTQAcgvnfeTYVLEKKIYAKINKEMLTR 554
Cdd:COG4192   476 KIEGLIERMDKIIKSLRQFSRKSdtplQPVDLRQVI---EQAWELVESRAKPQQI------TLHIPDDLMVQGDQVLLEQ 546

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 555 AFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPpeNIPKVFDRFFTERDnnepKGQGLGLYIVKSIIREHG 634
Cdd:COG4192   547 VLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFTTTKE----VGLGLGLSICRSIMQQFG 620

                         250
                  ....*....|....*....
gi 1578749287 635 GEIFVDSELGKGTVFTIKL 653
Cdd:COG4192   621 GDLYLASTLERGAMVILEF 639
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
557-653 8.40e-09

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 58.11  E-value: 8.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 557 ENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFfterdNNEPKGQGLGLYIVKSIIREHGGE 636
Cdd:COG2972   346 ENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-----SSKGEGRGIGLRNVRERLKLYYGE 420

                          90       100
                  ....*....|....*....|
gi 1578749287 637 ---IFVDSELGKGTVFTIKL 653
Cdd:COG2972   421 eygLEIESEPGEGTTVTIRI 440
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 434-498 1.16e-08

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 51.83  E-value: 1.16e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1578749287 434 LNERKRFLADVAHDLKAPVSAIQAFIDLIKvGNIHVDEETRTYLYAINQKSNEVQNRVRSLQEFT 498
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLE-EELLDDEEQREYLERIREEAERLLRLINDLLDLS 64
PRK10337 PRK10337
sensor protein QseC; Provisional
 426-634 1.49e-08

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 57.35  E-value: 1.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 426 RTNELttLLNERkRFLADVAHDLKAPVSAIQAFIDLIKVGniHVDEETRTYLYA-----INQKSNEVqNRVRSLQEFTSQ 500
Cdd:PRK10337  229 RTHAM--MVRER-RFTSDAAHELRSPLAALKVQTEVAQLS--DDDPQARKKALLqlhagIDRATRLV-DQLLTLSRLDSL 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 501 DkSIGISEKICLNNFIKEIYENNLPDTQACGVNFETYVLEKKIYAKINKEMLTRAFENLIYNALTFTPFDGKIILSMDkE 580
Cdd:PRK10337  303 D-NLQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLN-A 380

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1578749287 581 DGFaiiKISDNGKGIPPENIPKVFDRFFterdnnEPKGQ-----GLGLYIVKSIIREHG 634
Cdd:PRK10337  381 RNF---TVRDNGPGVTPEALARIGERFY------RPPGQeatgsGLGLSIVRRIAKLHG 430
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
390-653 2.11e-08

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 55.78  E-value: 2.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 390 GFVIVILFSVMMINRNRIiiKENEKLTRNLEHEVEvrtnelTTLLNERKRFLAD----VAHDLkapvSAIQAFIDLIKVG 465
Cdd:COG4585    15 GALLGLLLALVLLRARRA--ERAAELERELAARAE------EAREEERRRIARElhdgVGQSL----SAIKLQLEAARRL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 466 NIHVDEETRTYLYAINQKSNEVQNRVRSL--QEFTSQDKSIGISEkiCLNNFIKEIyennlpdTQACGVNFETYVlekki 543
Cdd:COG4585    83 LDADPEAAREELEEIRELAREALAELRRLvrGLRPPALDDLGLAA--ALEELAERL-------LRAAGIRVELDV----- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 544 yaKINKEMLTRAFENLIY--------NAL-----TftpfdgKIILSMDKEDGFAIIKISDNGKGIPPENIPkvfdrffte 610
Cdd:COG4585   149 --DGDPDRLPPEVELALYrivqealtNALkhagaT------RVTVTLEVDDGELTLTVRDDGVGFDPEAAP--------- 211

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1578749287 611 rdnnepkGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:COG4585   212 -------GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
571-655 2.18e-08

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 57.11  E-value: 2.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 571 GKIILSMDKEDGFAIIKISDNGKGIPPENI----------PKVFDRFFTERD-NN---EPK-----------GQGLGLYI 625
Cdd:COG0643   309 GTITLSAYHEGGRVVIEVSDDGRGLDLEKIrakaiekgliTAEEAAALSDEElLElifAPGfstaeevtdlsGRGVGMDV 388

                          90       100       110
                  ....*....|....*....|....*....|
gi 1578749287 626 VKSIIREHGGEIFVDSELGKGTVFTIKLSL 655
Cdd:COG0643   389 VKTNIEALGGTIEIESEPGKGTTFTLRLPL 418
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 558-655 3.70e-08

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 56.84  E-value: 3.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 558 NLIYNALTFTPfDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFteRDNNEPKGQGLGLYIVKSIIREHGGEI 637
Cdd:PRK11466  568 NLLSNALRFTD-EGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFV--QVSGKRGGTGLGLTISSRLAQAMGGEL 644

                          90
                  ....*....|....*...
gi 1578749287 638 FVDSELGKGTVFTIKLSL 655
Cdd:PRK11466  645 SATSTPEVGSCFCLRLPL 662
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 436-501 1.10e-07

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 49.13  E-value: 1.10e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1578749287 436 ERKRFLADVAHDLKAPVSAIQAFIDLIKvgNIHVDEETRTYLYAINQKSNEVQNRVRSLQEFTSQD 501
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLR--DEKLDEEQREYLETILRSAERLLRLINDLLDLSRIE 64
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 420-646 3.31e-07

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 53.37  E-value: 3.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 420 EHEVEVRTNELTTLLNERKRF------LADVAHDLKAPVSAIQAFIDLI-KVGNIHVDEETRTYLYAINQKSNEVQNRVR 492
Cdd:TIGR02938 253 EEQERARLSALQALMAEEERLeairetLSAAIHRLQGPMNLISAAISVLqRRGDDAGNPASAAMLQQALSAGREHMEALR 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 493 SLQEFTSQDKSIGISekicLNNFIKEIYENNLPDTQACGVNFEtYVLEKKIYAKINKEMLTRA-FENLIYNALTFTPFDG 571
Cdd:TIGR02938 333 QVIPQSPQEIVVPVN----LNQILRDVITLSTPRLLAAGIVVD-WQPAATLPAILGRELQLRSlFKALVDNAIEAMNIKG 407

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1578749287 572 ----KIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERDNNEpKGQGLGLYIVKSIIREHGGEIFVDSELGKG 646
Cdd:TIGR02938 408 wkrrELSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGGSR-KHIGMGLSVAQEIVADHGGIIDLDDDYSEG 485
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
431-638 3.46e-07

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 52.66  E-value: 3.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 431 TTLLNERKrFLADVAHDLKAPVSAIQAFIDLI-KVGNIhvdeETRTYLYAINQKSNEVQN-----RVRslQEFTSqdksi 504
Cdd:PRK10755  132 STLDQERL-FTADVAHELRTPLAGIRLHLELLeKQHHI----DVAPLIARLDQMMHTVEQllqlaRAG--QSFSS----- 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 505 GISEKICL-NNFIKEIYENNLPDTQACGVNFETYVLEKKIYAKINKEMLTRAFENLIYNALTFTPFDGKIILSMDKEDGF 583
Cdd:PRK10755  200 GHYQTVKLlEDVILPSQDELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGG 279

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1578749287 584 AIIKISDNGKGIPPENIPKVFDRFFteRDNNEPKGQGLGLYIVKSIIREHGGEIF 638
Cdd:PRK10755  280 AVLAVEDEGPGIDESKCGELSKAFV--RMDSRYGGIGLGLSIVSRITQLHHGQFF 332
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 436-501 5.12e-07

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 47.18  E-value: 5.12e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1578749287  436 ERKRFLADVAHDLKAPVSAIQAFIDLIKvgNIHVDEETRTYLYAINQKSNEVQNRVRSLQEFTSQD 501
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLL--DTELSEEQREYLETILREAERLLRLINDLLDLSRIE 64
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 544-651 1.43e-06

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 51.37  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 544 YAKINKEMLTRAFEnliynALTFTPFDGKII-LSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERdNNEPKGQGLG 622
Cdd:PRK15053  433 FAAIVGNLLDNAFE-----ASLRSDEGNKIVeLFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTR-ADEPGEHGIG 506

                          90       100
                  ....*....|....*....|....*....
gi 1578749287 623 LYIVKSIIREHGGEIFVDSELGKGTVFTI 651
Cdd:PRK15053  507 LYLIASYVTRCGGVITLEDNDPCGTLFSI 535
glnL PRK11073
nitrogen regulation protein NR(II);
584-655 1.97e-06

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 50.46  E-value: 1.97e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1578749287 584 AIIKISDNGKGIPPENIPKVFDRFFTERDNnepkGQGLGLYIVKSIIREHGGEIFVDSELGKgTVFTIKLSL 655
Cdd:PRK11073  281 ARIDIEDNGPGIPPHLQDTLFYPMVSGREG----GTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPI 347
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
411-644 2.03e-06

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 50.79  E-value: 2.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 411 ENEKLTRNLEHEVEVRTNELTTLL-NERKRF------LADVAHDLKAPVSAIQAFIDLIKVG-NIHVDEETRTYLYAINQ 482
Cdd:PRK10815  233 EREQLDPNPPRELTSLVRNLNRLLkNERERYtkyrttLTDLTHSLKTPLAVLQSTLRSLRSGkQMSVEQAEPIMLEQISR 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 483 KSNEV-----QNRVRSLQEFTSQDKSigiSEKICLNNFI---KEIYennlpdtQACGVNFE-------TYVLEKkiyaki 547
Cdd:PRK10815  313 ISQQIgyylhRASMRSEHNLLSRELH---SVAPLLDNLTsalNKVY-------QRKGVNITldispeiTFVGEK------ 376

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 548 NKEMltRAFENLIYNA----LTFTpfdgKIILSMDkEDGFAIIkISDNGKGIPPENIPKVFDRffTERDNNEPKGQGLGL 623
Cdd:PRK10815  377 NDFM--EVMGNVLDNAckycLEFV----EISARQT-DEHLHIV-VEDDGPGIPESKRELIFDR--GQRADTLRPGQGLGL 446

                         250       260
                  ....*....|....*....|..
gi 1578749287 624 YIVKSIIREHGGEIFV-DSELG 644
Cdd:PRK10815  447 SVAREITEQYEGKISAgDSPLG 468
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 572-654 2.36e-06

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 48.11  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 572 KIILSMDKEDgfAIIKISDNGKGIPPENIPKVFDRFFTER-----DNNEPK----------GQGLGLYIVKSIIREHGGE 636
Cdd:cd16929    74 KVTVAKGDED--LTIKISDRGGGIPREDLARLFSYMYSTApqpslDDFSDLisgtqpsplaGFGYGLPMSRLYAEYFGGD 151

                          90
                  ....*....|....*...
gi 1578749287 637 IFVDSELGKGTVFTIKLS 654
Cdd:cd16929   152 LDLQSMEGYGTDVYIYLK 169
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 558-655 2.49e-06

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 51.00  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 558 NLIYNALTFTPfDGKIILSMDK---EDGFAIIK--ISDNGKGIPPENIPKVFDRF------FTERDNnepkGQGLGLYIV 626
Cdd:PRK11107  415 NLVGNAIKFTE-SGNIDILVELralSNTKVQLEvqIRDTGIGISERQQSQLFQAFrqadasISRRHG----GTGLGLVIT 489

                          90       100
                  ....*....|....*....|....*....
gi 1578749287 627 KSIIREHGGEIFVDSELGKGTVFTIKLSL 655
Cdd:PRK11107  490 QKLVNEMGGDISFHSQPNRGSTFWFHLPL 518
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 557-653 6.98e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 42.41  E-value: 6.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 557 ENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTERdnnepKGQGLGLY-IVKSIIREHGG 635
Cdd:cd16957    11 ENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSE-----KGTGTALEnLNRRLIGLFGS 85

                          90       100
                  ....*....|....*....|
gi 1578749287 636 E--IFVDSELGKGTVFTIKL 653
Cdd:cd16957    86 EacLHIESEVHGGTEVWFVI 105
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
570-655 1.51e-04

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 41.82  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 570 DGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDrffterdnnEPKGQGLGLYIVKSIIREHGgeifVDSELGkGTVF 649
Cdd:COG2172    56 DGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYS---------TLAEGGRGLFLIRRLMDEVE----YESDPG-GTTV 121


                  ....*.
gi 1578749287 650 TIKLSL 655
Cdd:COG2172   122 RLVKRL 127
HATPase_TopVIB-like cd16933
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ...
 548-623 2.10e-04

Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.


Pssm-ID: 340410 [Multi-domain]  Cd Length: 203  Bit Score: 43.11  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 548 NKEM---------LTRAFENLIYNALTFTPFDG---KIILSMDKED-GFAIIKISDNGKGIPPENIPKVFDRFF--TERD 612
Cdd:cd16933     7 NKEMlgfdnpirsLYTTVRELVENSLDATEEAGilpDIKVEIEEIGkDHYKVIVEDNGPGIPEEQIPKVFGKVLygSKYH 86

                          90
                  ....*....|..
gi 1578749287 613 NNEPKGQ-GLGL 623
Cdd:cd16933    87 NKQSRGQqGLGI 98
PRK10618 PRK10618
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
 437-655 2.42e-04

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional


Pssm-ID: 236726 [Multi-domain]  Cd Length: 894  Bit Score: 44.54  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 437 RKRFLADVAHDLKAPVSAIQAFIDLIKvgNIHVDEETRTYLYAINQKSNEV---------QNRVRSlQEFTSQDKSIGIS 507
Cdd:PRK10618  450 RKAFLQNIGDELKQPLQSLAQLAAQLR--QTSDEEQQQPELDQLAEQSDVLvrlvdniqlLNMLET-QDWKPEQELFSLQ 526

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 508 EKIclNNFIKEIyennLPDTQACGVNFetyvlekKIYAKIN--------KEMLTRAFENLIYNALTFTPFdGKIILSMDK 579
Cdd:PRK10618  527 DLI--DEVLPEV----LPAIKRKGLQL-------LIHNHLKaeqlrigdRDALRKILLLLLNYAITTTAY-GKITLEVDQ 592

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 580 EDGFA---IIKISDNGKGIPPENI---------PKVFDRFFterdnnepKGQGLGLYIVKSIIREHGGEIFVDSELGKGT 647
Cdd:PRK10618  593 DESSPdrlTIRILDTGAGVSIKELdnlhfpflnQTQGDRYG--------KASGLTFFLCNQLCRKLGGHLTIKSREGLGT 664


                  ....*...
gi 1578749287 648 VFTIKLSL 655
Cdd:PRK10618  665 RYSIHLKM 672
COG1389 COG1389
DNA topoisomerase VI, subunit B [Replication, recombination and repair];
548-608 3.47e-04

DNA topoisomerase VI, subunit B [Replication, recombination and repair];


Pssm-ID: 440999 [Multi-domain]  Cd Length: 530  Bit Score: 43.66  E-value: 3.47e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1578749287 548 NKEML-----TRA----FENLIYNALTFTPFDG---KIILSMDKEDGFAIIKIS--DNGKGIPPENIPKVFDRFF 608
Cdd:COG1389    23 NKQLLgfdspARAlyttVKEAVDNSLDACEEAGilpDIKVSIERVDGKDIYRVTveDNGPGIPPEQIPKVFGKLL 97
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 579-609 3.90e-04

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 42.04  E-value: 3.90e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1578749287 579 KEDGFAIIKISDNGKGIPPENIPKVFDRFFT 609
Cdd:cd16926    38 EEGGLKLIRVTDNGSGISREDLELAFERHAT 68
PRK04184 PRK04184
DNA topoisomerase VI subunit B; Validated
 548-608 4.35e-04

DNA topoisomerase VI subunit B; Validated


Pssm-ID: 235246 [Multi-domain]  Cd Length: 535  Bit Score: 43.34  E-value: 4.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1578749287 548 NKEML-----TRA----FENLIYNALTFT------PfDGKI-ILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFF 608
Cdd:PRK04184   24 NKELLgfdnpARAlyttVKELVDNSLDACeeagilP-DIKIeIKRVDEGKDHYRVTVEDNGPGIPPEEIPKVFGKLL 99
COG4768 COG4768
Uncharacterized conserved protein YoxC, contains an MCP-like domain [Function unknown];
390-521 8.86e-04

Uncharacterized conserved protein YoxC, contains an MCP-like domain [Function unknown];


Pssm-ID: 443800 [Multi-domain]  Cd Length: 132  Bit Score: 39.83  E-value: 8.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 390 GFVIVILFSVMMINRNRIIIKENEKLTRNLEHEVEVRTNELTTLLNERKRFLADVAHDLKapvsAIQAFIDLIK-VGNih 468
Cdd:COG4768    13 AFLVLVIYLVKTLKKVKKTLNEVNKTLEGLEKQLDGITTETTDLLHKTNRLAEDVNGKVE----KLDPLFDAVKdVGE-- 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1578749287 469 vdeetrtylyAINQKSNEVQNRVRSLQEFTSQDKSIgISEKICLNNFIKEIYE 521
Cdd:COG4768    87 ----------SVSDLNSSLRDVTSSVSSKVEKNSEK-VAQVVKWGKVALGLFK 128
7TMR-DISM_7TM pfam07695
7TM diverse intracellular signalling; This entry represents the transmembrane region of the ...
 194-404 9.07e-04

7TM diverse intracellular signalling; This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).


Pssm-ID: 429600 [Multi-domain]  Cd Length: 207  Bit Score: 41.11  E-value: 9.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 194 RLLFYSIICFTTFAIAIFSLSVWFlSNKSKIYLYFGCMCVFFAIHVSYPFVHLLGLPLVSFTYAVEDLSYFMVVLCIICI 273
Cdd:pfam07695   1 ENLLLGLFYGILLALALYNLFLFF-SLRDRSYLYYVLYLLSFLLYQLSLNGLGFQYLWPNAPPWLNNKLLYLSLLLLLPF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 274 NGSI-------SKIEENKVYRFLILPLGItmsiisivIPIILLPYDMYFVNIYGKLIDIYKYIVFIYILMSSLVSIYKKt 346
Cdd:pfam07695  80 FALLfarsfleLKKYLPRLLRLLLGLALL--------LALLLLLLPLFPYTLSLPLAQLLALLFILFLLLLGIIAWRKG- 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 347 csEHISSYILVSVnTVFGISILFDAVTSNRFEP--IFTGWQTEYCGFVIVILFSVMMINR 404
Cdd:pfam07695 151 --YKPARYFLLAW-LLLLIGALIDILSLLGLLPsnFFTNYLLQIGSALEVLLLSLALADR 207
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 581-653 3.05e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 37.15  E-value: 3.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1578749287 581 DGFAIIKISDNGKGIPPEnipkvfdrffterdnNEPKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKL 653
Cdd:cd16917    29 ADELTLTVVDDGVGFDGP---------------APPGGGGFGLLGMRERAELLGGTLTIGSRPGGGTRVTARL 86
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 557-653 3.22e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 37.42  E-value: 3.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 557 ENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPEnipkvfdrffTERDNNEPKGQGLGLYIVKSIIREHGGE 636
Cdd:cd16956    11 ENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPD----------TLARILIRSSNGLGLNLVDKRLRQAFGN 80

                          90       100
                  ....*....|....*....|
gi 1578749287 637 IF---VDSELGKGTVFTIKL 653
Cdd:cd16956    81 DYgldIECAPGEGTRITIRL 100
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 552-655 8.01e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 37.17  E-value: 8.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578749287 552 LTRAFENLIYNAL----TFTPFDGKIILSMDKEDGFAIIKISdNGKgipPENIPKVFDRFFTE-RDNNEpkgqGLGLYIV 626
Cdd:cd16935    37 LCIIFGNLLDNAIeacaKIDKENRFIHLKIRQKKGFLIISIE-NSY---EGELKKKNGLFLSTkKDKNH----GIGLKSI 108

                          90       100
                  ....*....|....*....|....*....
gi 1578749287 627 KSIIREHGGEIFVDSELGkgtVFTIKLSL 655
Cdd:cd16935   109 REIVKKYNGNLSIEYENG---IFTLSILL 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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