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Conserved domains on  [gi|1615792044|emb|VGM69582|]
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Serpentine Receptor, class J [Caenorhabditis elegans]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 1-259 5.17e-114

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10319:

Pssm-ID: 419896  Cd Length: 310  Bit Score: 331.90  E-value: 5.17e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044   1 MFINWAHFIIPKITFILSFIANPVFVYLIRTEKVIQFGDYRYLLYFFAIFNLTASVVDILIPACVYSYRYAAVFFIVDSV 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044  81 FSERSNFAPTLISLRCAFIAGTYGILNIHFIFRYNVLKNTSFVSHYFMPYGLILSIFLVIFHIGLWTFVVEPTMYSSDES 160
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044 161 RNYVRQAFQEEYGVDVNTISTKIAVYAEASSGIVFRAWIGTGVVTVIASYSMTLYFVLGYKfqIMSGLNQGSATMSLKTA 240
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYK--IMRKLNKMSVTMSKKTK 238

                         250
                  ....*....|....*....
gi 1615792044 241 QMQKRLFWALTIQTIIPIC 259
Cdd:pfam10319 239 RLQKQLLKALIVQTIIPIC 257
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-259 5.17e-114

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 331.90  E-value: 5.17e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044   1 MFINWAHFIIPKITFILSFIANPVFVYLIRTEKVIQFGDYRYLLYFFAIFNLTASVVDILIPACVYSYRYAAVFFIVDSV 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044  81 FSERSNFAPTLISLRCAFIAGTYGILNIHFIFRYNVLKNTSFVSHYFMPYGLILSIFLVIFHIGLWTFVVEPTMYSSDES 160
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044 161 RNYVRQAFQEEYGVDVNTISTKIAVYAEASSGIVFRAWIGTGVVTVIASYSMTLYFVLGYKfqIMSGLNQGSATMSLKTA 240
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYK--IMRKLNKMSVTMSKKTK 238

                         250
                  ....*....|....*....
gi 1615792044 241 QMQKRLFWALTIQTIIPIC 259
Cdd:pfam10319 239 RLQKQLLKALIVQTIIPIC 257
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-259 5.17e-114

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 331.90  E-value: 5.17e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044   1 MFINWAHFIIPKITFILSFIANPVFVYLIRTEKVIQFGDYRYLLYFFAIFNLTASVVDILIPACVYSYRYAAVFFIVDSV 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044  81 FSERSNFAPTLISLRCAFIAGTYGILNIHFIFRYNVLKNTSFVSHYFMPYGLILSIFLVIFHIGLWTFVVEPTMYSSDES 160
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044 161 RNYVRQAFQEEYGVDVNTISTKIAVYAEASSGIVFRAWIGTGVVTVIASYSMTLYFVLGYKfqIMSGLNQGSATMSLKTA 240
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYK--IMRKLNKMSVTMSKKTK 238

                         250
                  ....*....|....*....
gi 1615792044 241 QMQKRLFWALTIQTIIPIC 259
Cdd:pfam10319 239 RLQKQLLKALIVQTIIPIC 257
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-260 2.75e-33

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 124.11  E-value: 2.75e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044   8 FIIPKITFILSFIANPVFVYLIRTEKVIQFGDYRYLLYFFAIFNLTASVVDILIPACVYSYRYAAVFFIVDSVFSERSNF 87
Cdd:pfam10326   2 HIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044  88 APTLISLRCAFIAGTYGILNIHFIFRYNVLKNTSFVsHYFMPYGLILSIFLVIFHIGLWTFVVEPTMYSSDESRNYVRQA 167
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKL-KYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044 168 FQEEYGVDVNTISTKIAVY----AEASSGIVFRAWIGTGVVTVI--ASYSMTLYFvlGYKfqIMSGLNQGSATMSLKTAQ 241
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYyptdENGSKVIRWRSLIGLLIMTFIigISFSIIIYC--GIK--MYFKMKKLKSLGSEKTRK 236

                         250
                  ....*....|....*....
gi 1615792044 242 MQKRLFWALTIQTIIPICL 260
Cdd:pfam10326 237 LQKQLFKALVIQTLIPTIL 255
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 13-259 1.19e-07

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 52.17  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044  13 ITFILSFIANPVFVYLIRTEKVIQFGDYRYLLYFFAIFNLTASVVDILI---------PACVYSY---RYaavffivdsv 80
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTqqriipngvSMALISYgpcKY---------- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044  81 FSERSNFapTLISLRCAFIAGTYGILNIHFIFRYNVLKNTSFVSHYFMPYGLILSIFLVIFHIGLWTFVVEPtmyssDES 160
Cdd:pfam10317  77 FGPWFCY--SGYSLLQHFLLHSGWSLLLTFYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTDF-----LPV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044 161 RNYVRQAFqEEYGVDVNTISTKIAVYAEASSgivfrawIGTGVVTVIASYSMTLYFVLGYKfqIMSGLNQGSATMSLKTA 240
Cdd:pfam10317 150 EALTKELH-PNYNLTDYTVTGFSDLQSFPAL-------INTLIMTIPVFPIPIIILILRRK--ILKLLNSNSVNMSPTTK 219

                         250
                  ....*....|....*....
gi 1615792044 241 QMQKRLFWALTIQTIIPIC 259
Cdd:pfam10317 220 AQHRQLIKGLTIQALLPLF 238
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 110-282 1.42e-04

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 42.92  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044 110 FIFRYNVLKNTSFVSHyfmpyGLILSIFLVIFHIGLWTFVVEPTMYSSDESRNYVRQAFQEeYGVDVNTISTKIAVYAEA 189
Cdd:pfam10318 107 FENRYSILFTNKKRIT-----WKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVLKK-LPCLPPEFFDNPPVFVLA 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1615792044 190 SSGIVFRAWIGTGVVTVIASysmTLYFVLgykFQIMSGLNQGSATMSLKTAQMQKRLFWALTIQTIIPICldkLGFCNCN 269
Cdd:pfam10318 181 IDSTYFLICIVLLILILIIQ---ILFFVF---LTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSIPLI---VILIPLI 251

                         170
                  ....*....|...
gi 1615792044 270 FVFpISGSSGYYN 282
Cdd:pfam10318 252 YIL-FSIIFGYYN 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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