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Conserved domains on  [gi|1676316597|emb|VHY00971|]
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pyridine nucleotide-disulfide oxidoreductase [Clostridioides difficile]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11449903)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.50.50.60
EC:  1.14.13.-
Gene Ontology:  GO:0050660|GO:0050661|GO:0000166
PubMed:  30945211|31869345|25704928
SCOP:  4000073

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
5-417 1.86e-170

Predicted flavoprotein YhiN [General function prediction only];


:

Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 483.01  E-value: 1.86e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597   5 IVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATGGGRCNFTNNREIEDFFDKVVSNKKFLYSSFYTFTNKDLIS 84
Cdd:COG2081     1 IVIGAGAAGLMAAITAAERGARVLLLEKNPKVGRKILISGGGRCNFTNSEPLPEFLNYYGGNPHFLKSALSRFTPEDLIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597  85 YFESRNLEYKIEKENdhKVYTKNDKSIEVIEVLNKDLLNHNVKIMYNKKVIDIITEEIALkddsnkdkskylikGIILDN 164
Cdd:COG2081    81 FFEGLGIETKEESSG--RVFPDSSKASDILRALLAELREAGVEIRLRTRVTGIEKEDGGF--------------GVETPD 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 165 GDKILGDKVIISTGGVSYSKTGSDGSMYKILKKHGHTLNKLYPALVPLTIEEKWIKDLQGISMKNVEISCKIKKRKISKs 244
Cdd:COG2081   145 GETVRADAVVLATGGLSYPKLGSTGDGYRLAEQFGHTITPLRPALVPLTLSEHFFKRLAGLSLKNVALSVGGKKIASFR- 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 245 GDMLFAHFGITGPCVLIMSSYINKIIEKEKVELNIDFLPNLSTDEISSII----RAFPNKNVLNNLKQILPQNFLREIFS 320
Cdd:COG2081   224 GELLFTHRGLSGPAILQLSSYWRDALKKGGATLTIDLLPDLDLEELDARLarprEKNGKKSLKNVLRGLLPKRLAALLLE 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 321 LLSLvDKKASDLSKADEIRIIEYIKNMKLTCNGTTGINTGMVTSGGISVKEINSSTMESKLVKNLFFTGEVIDIDAETGG 400
Cdd:COG2081   304 LADP-DKPLAQLSKKEREALAALLKAWPLTPTGTRGYDEAIVTAGGVDTKELDPKTMESKKVPGLYFAGEVLDVDGPTGG 382

                         410
                  ....*....|....*..
gi 1676316597 401 YNLQIAFSTGYLAGISV 417
Cdd:COG2081   383 YNLQWAWSSGYAAGQAA 399
 
Name Accession Description Interval E-value
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
5-417 1.86e-170

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 483.01  E-value: 1.86e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597   5 IVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATGGGRCNFTNNREIEDFFDKVVSNKKFLYSSFYTFTNKDLIS 84
Cdd:COG2081     1 IVIGAGAAGLMAAITAAERGARVLLLEKNPKVGRKILISGGGRCNFTNSEPLPEFLNYYGGNPHFLKSALSRFTPEDLIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597  85 YFESRNLEYKIEKENdhKVYTKNDKSIEVIEVLNKDLLNHNVKIMYNKKVIDIITEEIALkddsnkdkskylikGIILDN 164
Cdd:COG2081    81 FFEGLGIETKEESSG--RVFPDSSKASDILRALLAELREAGVEIRLRTRVTGIEKEDGGF--------------GVETPD 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 165 GDKILGDKVIISTGGVSYSKTGSDGSMYKILKKHGHTLNKLYPALVPLTIEEKWIKDLQGISMKNVEISCKIKKRKISKs 244
Cdd:COG2081   145 GETVRADAVVLATGGLSYPKLGSTGDGYRLAEQFGHTITPLRPALVPLTLSEHFFKRLAGLSLKNVALSVGGKKIASFR- 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 245 GDMLFAHFGITGPCVLIMSSYINKIIEKEKVELNIDFLPNLSTDEISSII----RAFPNKNVLNNLKQILPQNFLREIFS 320
Cdd:COG2081   224 GELLFTHRGLSGPAILQLSSYWRDALKKGGATLTIDLLPDLDLEELDARLarprEKNGKKSLKNVLRGLLPKRLAALLLE 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 321 LLSLvDKKASDLSKADEIRIIEYIKNMKLTCNGTTGINTGMVTSGGISVKEINSSTMESKLVKNLFFTGEVIDIDAETGG 400
Cdd:COG2081   304 LADP-DKPLAQLSKKEREALAALLKAWPLTPTGTRGYDEAIVTAGGVDTKELDPKTMESKKVPGLYFAGEVLDVDGPTGG 382

                         410
                  ....*....|....*..
gi 1676316597 401 YNLQIAFSTGYLAGISV 417
Cdd:COG2081   383 YNLQWAWSSGYAAGQAA 399
TIGR00275 TIGR00275
flavoprotein, HI0933 family; The model when searched with a partial length search brings in ...
 5-414 1.79e-161

flavoprotein, HI0933 family; The model when searched with a partial length search brings in proteins with a dinucleotide-binding motif (Rossman fold) over the initial 40 residues of the model, including oxidoreductases and dehydrogenases. Partially characterized members include an FAD-binding protein from Bacillus cereus and flavoprotein HI0933 from Haemophilus influenzae. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272992 [Multi-domain]  Cd Length: 400  Bit Score: 460.14  E-value: 1.79e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597   5 IVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATGGGRCNFTNNREIEDFFDKVVSNKKFLYSSFYTFTNKDLIS 84
Cdd:TIGR00275   1 IIIGGGAAGLMAAITAARAGLSVLLLEKNKKIGKKLLISGGGRCNLTNSCPTPEFVAYYPRNGKFLRSALSRFSNKDLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597  85 YFESRNLEYKIEKenDHKVYTKNDKSIEVIEVLNKDLLNHNVKIMYNKKVIDIIteeialkddsnKDKSKYLIKgiilDN 164
Cdd:TIGR00275  81 FFESLGLELKVEE--DGRVFPCSDSAADVLDALLNELKELGVEILTNSKVKSIE-----------KEDGGFGVE----TS 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 165 GDKILGDKVIISTGGVSYSKTGSDGSMYKILKKHGHTLNKLYPALVPLTIEEKWIKDLQGISMKNVEISCKIKKRKISKS 244
Cdd:TIGR00275 144 GGEYEADKVIIATGGLSYPQLGSTGDGYEIAESLGHTIVPPVPALVPLTLDESFLKELSGISLDGVVLSLVNGKKVLEEF 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 245 GDMLFAHFGITGPCVLIMSSYINKIIEKEK-VELNIDFLPNLSTDEISSIIRA----FPNKNVLNNLKQILPQNFLREIF 319
Cdd:TIGR00275 224 GELLFTHFGLSGPAILDLSAFAARALLKHKgVELEIDLLPDLSEEELEQRLKRlrksNPKKTVKNILKGLLPKRLAELLL 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 320 SLLS-LVDKKASDLSKADEIRIIEYIKNMKLTCNGTTGINTGMVTSGGISVKEINSSTMESKLVKNLFFTGEVIDIDAET 398
Cdd:TIGR00275 304 EQLGiDPDLPAAQLSKKEIKKLVQLLKNWPFTISGTRGFKEAEVTAGGVSLKEINPKTMESKLVPGLYFAGEVLDIDGDT 383

                         410
                  ....*....|....*.
gi 1676316597 399 GGYNLQIAFSTGYLAG 414
Cdd:TIGR00275 384 GGYNLQWAWSSGYLAG 399
HI0933_like pfam03486
HI0933-like protein;
3-414 7.81e-158

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 450.88  E-value: 7.81e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597   3 KVIVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATGGGRCNFTN-NREIEDFFDKVVSNKKFLYSSFYTFTNKD 81
Cdd:pfam03486   2 DVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGRKILISGGGRCNVTNlSEEPDNFLSRYPGNPKFLKSALSRFTPWD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597  82 LISYFESRNLEYKIEkenDH-KVYTKNDKSIEVIEVLNKDLLNHNVKIMYNKKVIDIITEeialkddsnkDKSKYLIKgi 160
Cdd:pfam03486  82 FIAFFESLGVPLKEE---DHgRLFPDSDKASDIVDALLNELKELGVKIRLRTRVLSVEKD----------DDGRFRVK-- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 161 ilDNGDKILGDKVIISTGGVSYSKTGSDGSMYKILKKHGHTLNKLYPALVPLTIEEKWI--KDLQGISMKNVEISCKIKK 238
Cdd:pfam03486 147 --TGGEELEADSLVLATGGLSWPKTGSTGFGYPLAEQFGHTIIPLRPALVPFTIDEPFLflKRLSGISLKNVVLSNGKGG 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 239 RKISksGDMLFAHFGITGPCVLIMSSYINKIIE-KEKVELNIDFLPNLSTDEISSIIR----AFPNKNVLNNLKQILPQN 313
Cdd:pfam03486 225 ITFR--GELLFTHRGLSGPAILQLSSYWRRAILkKGGVTLSIDLLPDLDAEELAARLEkprgAHPKKSLKNSLAGLLPKR 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 314 FLREIFSLLSL-VDKKASDLSKADEIRIIEYIKNMKLTCNGTTGINTGMVTSGGISVKEINSSTMESKLVKNLFFTGEVI 392
Cdd:pfam03486 303 LAEFLLEQAGIePDKKLAQLSKKELAALAQLLKAWTFTPNGTEGYRTAEVTAGGVDTKELSSKTMESKKVPGLFFAGEVL 382

                         410       420
                  ....*....|....*....|..
gi 1676316597 393 DIDAETGGYNLQIAFSTGYLAG 414
Cdd:pfam03486 383 DVDGWTGGYNLQWAWSSGYAAG 404
PTZ00058 PTZ00058
glutathione reductase; Provisional
 5-179 1.44e-05

glutathione reductase; Provisional


Pssm-ID: 185420 [Multi-domain]  Cd Length: 561  Bit Score: 47.30  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597   5 IVVGGGASGMMAALSASKNNNEVILVErngelgrklRATGGGRCNFTNNREIEDFFDKVVSNKKFLYSSFYTFTNKDLIS 84
Cdd:PTZ00058   52 IVIGGGSGGMAAARRAARNKAKVALVE---------KDYLGGTCVNVGCVPKKIMFNAASIHDILENSRHYGFDTQFSFN 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597  85 Y--FESRNLEYkIEKENDhkVYTKNDKSIEVievlnkDLLNHNVKIM-YNKKVIDIITEEIALKDDSNKDKSKYLIKGII 161
Cdd:PTZ00058  123 LplLVERRDKY-IRRLND--IYRQNLKKDNV------EYFEGKGSLLsENQVLIKKVSQVDGEADESDDDEVTIVSAGVS 193

                         170
                  ....*....|....*....
gi 1676316597 162 -LDNGDKILGDKVIISTGG 179
Cdd:PTZ00058  194 qLDDGQVIEGKNILIAVGN 212
 
Name Accession Description Interval E-value
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
5-417 1.86e-170

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 483.01  E-value: 1.86e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597   5 IVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATGGGRCNFTNNREIEDFFDKVVSNKKFLYSSFYTFTNKDLIS 84
Cdd:COG2081     1 IVIGAGAAGLMAAITAAERGARVLLLEKNPKVGRKILISGGGRCNFTNSEPLPEFLNYYGGNPHFLKSALSRFTPEDLIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597  85 YFESRNLEYKIEKENdhKVYTKNDKSIEVIEVLNKDLLNHNVKIMYNKKVIDIITEEIALkddsnkdkskylikGIILDN 164
Cdd:COG2081    81 FFEGLGIETKEESSG--RVFPDSSKASDILRALLAELREAGVEIRLRTRVTGIEKEDGGF--------------GVETPD 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 165 GDKILGDKVIISTGGVSYSKTGSDGSMYKILKKHGHTLNKLYPALVPLTIEEKWIKDLQGISMKNVEISCKIKKRKISKs 244
Cdd:COG2081   145 GETVRADAVVLATGGLSYPKLGSTGDGYRLAEQFGHTITPLRPALVPLTLSEHFFKRLAGLSLKNVALSVGGKKIASFR- 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 245 GDMLFAHFGITGPCVLIMSSYINKIIEKEKVELNIDFLPNLSTDEISSII----RAFPNKNVLNNLKQILPQNFLREIFS 320
Cdd:COG2081   224 GELLFTHRGLSGPAILQLSSYWRDALKKGGATLTIDLLPDLDLEELDARLarprEKNGKKSLKNVLRGLLPKRLAALLLE 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 321 LLSLvDKKASDLSKADEIRIIEYIKNMKLTCNGTTGINTGMVTSGGISVKEINSSTMESKLVKNLFFTGEVIDIDAETGG 400
Cdd:COG2081   304 LADP-DKPLAQLSKKEREALAALLKAWPLTPTGTRGYDEAIVTAGGVDTKELDPKTMESKKVPGLYFAGEVLDVDGPTGG 382

                         410
                  ....*....|....*..
gi 1676316597 401 YNLQIAFSTGYLAGISV 417
Cdd:COG2081   383 YNLQWAWSSGYAAGQAA 399
TIGR00275 TIGR00275
flavoprotein, HI0933 family; The model when searched with a partial length search brings in ...
 5-414 1.79e-161

flavoprotein, HI0933 family; The model when searched with a partial length search brings in proteins with a dinucleotide-binding motif (Rossman fold) over the initial 40 residues of the model, including oxidoreductases and dehydrogenases. Partially characterized members include an FAD-binding protein from Bacillus cereus and flavoprotein HI0933 from Haemophilus influenzae. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272992 [Multi-domain]  Cd Length: 400  Bit Score: 460.14  E-value: 1.79e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597   5 IVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATGGGRCNFTNNREIEDFFDKVVSNKKFLYSSFYTFTNKDLIS 84
Cdd:TIGR00275   1 IIIGGGAAGLMAAITAARAGLSVLLLEKNKKIGKKLLISGGGRCNLTNSCPTPEFVAYYPRNGKFLRSALSRFSNKDLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597  85 YFESRNLEYKIEKenDHKVYTKNDKSIEVIEVLNKDLLNHNVKIMYNKKVIDIIteeialkddsnKDKSKYLIKgiilDN 164
Cdd:TIGR00275  81 FFESLGLELKVEE--DGRVFPCSDSAADVLDALLNELKELGVEILTNSKVKSIE-----------KEDGGFGVE----TS 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 165 GDKILGDKVIISTGGVSYSKTGSDGSMYKILKKHGHTLNKLYPALVPLTIEEKWIKDLQGISMKNVEISCKIKKRKISKS 244
Cdd:TIGR00275 144 GGEYEADKVIIATGGLSYPQLGSTGDGYEIAESLGHTIVPPVPALVPLTLDESFLKELSGISLDGVVLSLVNGKKVLEEF 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 245 GDMLFAHFGITGPCVLIMSSYINKIIEKEK-VELNIDFLPNLSTDEISSIIRA----FPNKNVLNNLKQILPQNFLREIF 319
Cdd:TIGR00275 224 GELLFTHFGLSGPAILDLSAFAARALLKHKgVELEIDLLPDLSEEELEQRLKRlrksNPKKTVKNILKGLLPKRLAELLL 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 320 SLLS-LVDKKASDLSKADEIRIIEYIKNMKLTCNGTTGINTGMVTSGGISVKEINSSTMESKLVKNLFFTGEVIDIDAET 398
Cdd:TIGR00275 304 EQLGiDPDLPAAQLSKKEIKKLVQLLKNWPFTISGTRGFKEAEVTAGGVSLKEINPKTMESKLVPGLYFAGEVLDIDGDT 383

                         410
                  ....*....|....*.
gi 1676316597 399 GGYNLQIAFSTGYLAG 414
Cdd:TIGR00275 384 GGYNLQWAWSSGYLAG 399
HI0933_like pfam03486
HI0933-like protein;
3-414 7.81e-158

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 450.88  E-value: 7.81e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597   3 KVIVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATGGGRCNFTN-NREIEDFFDKVVSNKKFLYSSFYTFTNKD 81
Cdd:pfam03486   2 DVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGRKILISGGGRCNVTNlSEEPDNFLSRYPGNPKFLKSALSRFTPWD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597  82 LISYFESRNLEYKIEkenDH-KVYTKNDKSIEVIEVLNKDLLNHNVKIMYNKKVIDIITEeialkddsnkDKSKYLIKgi 160
Cdd:pfam03486  82 FIAFFESLGVPLKEE---DHgRLFPDSDKASDIVDALLNELKELGVKIRLRTRVLSVEKD----------DDGRFRVK-- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 161 ilDNGDKILGDKVIISTGGVSYSKTGSDGSMYKILKKHGHTLNKLYPALVPLTIEEKWI--KDLQGISMKNVEISCKIKK 238
Cdd:pfam03486 147 --TGGEELEADSLVLATGGLSWPKTGSTGFGYPLAEQFGHTIIPLRPALVPFTIDEPFLflKRLSGISLKNVVLSNGKGG 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 239 RKISksGDMLFAHFGITGPCVLIMSSYINKIIE-KEKVELNIDFLPNLSTDEISSIIR----AFPNKNVLNNLKQILPQN 313
Cdd:pfam03486 225 ITFR--GELLFTHRGLSGPAILQLSSYWRRAILkKGGVTLSIDLLPDLDAEELAARLEkprgAHPKKSLKNSLAGLLPKR 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597 314 FLREIFSLLSL-VDKKASDLSKADEIRIIEYIKNMKLTCNGTTGINTGMVTSGGISVKEINSSTMESKLVKNLFFTGEVI 392
Cdd:pfam03486 303 LAEFLLEQAGIePDKKLAQLSKKELAALAQLLKAWTFTPNGTEGYRTAEVTAGGVDTKELSSKTMESKKVPGLFFAGEVL 382

                         410       420
                  ....*....|....*....|..
gi 1676316597 393 DIDAETGGYNLQIAFSTGYLAG 414
Cdd:pfam03486 383 DVDGWTGGYNLQWAWSSGYAAG 404
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
3-41 2.61e-08

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 56.02  E-value: 2.61e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1676316597   3 KVIVVGGGASGMMAALSASKNNNEVILVERNGELGRKLR 41
Cdd:COG1148   142 RALVIGGGIAGMTAALELAEQGYEVYLVEKEPELGGRAA 180
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 4-179 8.71e-08

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 54.07  E-value: 8.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597   4 VIVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATGGGrCNFTNNRE--------IEDFFDKVVSNKKFLyssfy 75
Cdd:COG1053     6 VVVVGSGGAGLRAALEAAEAGLKVLVLEKVPPRGGHTAAAQGG-INAAGTNVqkaagedsPEEHFYDTVKGGDGL----- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597  76 tfTNKDLISYF-----------ESRNLEYKIEKEND------HKV----YTKNDKSIEVIEVLNKDLLNHNVKIMYNKKV 134
Cdd:COG1053    80 --ADQDLVEALaeeapeaidwlEAQGVPFSRTPDGRlpqfggHSVgrtcYAGDGTGHALLATLYQAALRLGVEIFTETEV 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1676316597 135 IDIITEeialkDDSnkdkskylIKGIILDNGD----KILGDKVIISTGG 179
Cdd:COG1053   158 LDLIVD-----DGR--------VVGVVARDRTgeivRIRAKAVVLATGG 193
FAD_oxidored pfam12831
FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases ...
 4-53 1.21e-07

FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases and related proteins.


Pssm-ID: 432816 [Multi-domain]  Cd Length: 420  Bit Score: 53.38  E-value: 1.21e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1676316597   4 VIVVGGGASGMMAALSASKNNNEVILVERNGELGRKlrATGGGRCNFTNN 53
Cdd:pfam12831   2 VVVVGGGPAGVAAAIAAARAGAKVLLVERRGFLGGM--LTSGLVGPDMGF 49
PTZ00058 PTZ00058
glutathione reductase; Provisional
 5-179 1.44e-05

glutathione reductase; Provisional


Pssm-ID: 185420 [Multi-domain]  Cd Length: 561  Bit Score: 47.30  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597   5 IVVGGGASGMMAALSASKNNNEVILVErngelgrklRATGGGRCNFTNNREIEDFFDKVVSNKKFLYSSFYTFTNKDLIS 84
Cdd:PTZ00058   52 IVIGGGSGGMAAARRAARNKAKVALVE---------KDYLGGTCVNVGCVPKKIMFNAASIHDILENSRHYGFDTQFSFN 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597  85 Y--FESRNLEYkIEKENDhkVYTKNDKSIEVievlnkDLLNHNVKIM-YNKKVIDIITEEIALKDDSNKDKSKYLIKGII 161
Cdd:PTZ00058  123 LplLVERRDKY-IRRLND--IYRQNLKKDNV------EYFEGKGSLLsENQVLIKKVSQVDGEADESDDDEVTIVSAGVS 193

                         170
                  ....*....|....*....
gi 1676316597 162 -LDNGDKILGDKVIISTGG 179
Cdd:PTZ00058  194 qLDDGQVIEGKNILIAVGN 212
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 4-46 2.14e-05

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 46.51  E-value: 2.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1676316597   4 VIVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATGGG 46
Cdd:pfam00890   2 VLVIGGGLAGLAAALAAAEAGLKVAVVEKGQPFGGATAWSSGG 44
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 3-179 4.17e-05

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 45.00  E-value: 4.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597   3 KVIVVGGGASGMMAALSASKNNNEVILVERNGELgrklratGGGRCNFTnnreiedffdkvvsnKKFLYSSFytftNKDL 82
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQLGGKVTLIEDEGTC-------PYGGCVLS---------------KALLGAAE----APEI 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597  83 ISYFEsrnleykiekendhKVYTKNDKSIevievlnkDLLNHNVKIMYNKKVIDIIteeialkddsnKDKSKYLIKGIIL 162
Cdd:pfam07992  56 ASLWA--------------DLYKRKEEVV--------KKLNNGIEVLLGTEVVSID-----------PGAKKVVLEELVD 102

                         170
                  ....*....|....*..
gi 1676316597 163 DNGDKILGDKVIISTGG 179
Cdd:pfam07992 103 GDGETITYDRLVIATGA 119
PRK07843 PRK07843
3-oxosteroid 1-dehydrogenase;
4-46 4.70e-05

3-oxosteroid 1-dehydrogenase;


Pssm-ID: 236111 [Multi-domain]  Cd Length: 557  Bit Score: 45.41  E-value: 4.70e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1676316597   4 VIVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATGGG 46
Cdd:PRK07843   10 VVVVGSGAAGMVAALTAAHRGLSTVVVEKAPHYGGSTARSGGG 52
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 3-37 1.27e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 43.93  E-value: 1.27e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1676316597   3 KVIVVGGGASGMMAALSASKNNNEVILVERNGELG 37
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDPG 35
PRK06847 PRK06847
hypothetical protein; Provisional
 1-46 2.45e-04

hypothetical protein; Provisional


Pssm-ID: 235874 [Multi-domain]  Cd Length: 375  Bit Score: 42.94  E-value: 2.45e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1676316597   1 MSKVIVVGGGASGMMAALSASKNNNEVILVERNgelgRKLRATGGG 46
Cdd:PRK06847    4 VKKVLIVGGGIGGLSAAIALRRAGIAVDLVEID----PEWRVYGAG 45
PTZ00306 PTZ00306
NADH-dependent fumarate reductase; Provisional
 2-185 3.62e-04

NADH-dependent fumarate reductase; Provisional


Pssm-ID: 140327 [Multi-domain]  Cd Length: 1167  Bit Score: 42.84  E-value: 3.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597    2 SKVIVVGGGASGMMAALSASKNNNEVILVERNGEL-GRKLRATGGGRCNFTNNREIEDFFDkvvsNKKFLYSSFY----- 75
Cdd:PTZ00306   410 ARVIVVGGGLAGCSAAIEAASCGAQVILLEKEAKLgGNSAKATSGINGWGTRAQAKQDVLD----GGKFFERDTHlsgkg 485

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316597   76 ---------TFTNK--DLISYFESRNLEYKI-------EKENDHKVYTKNDKS--------IEVIE--VLNKdlLNHNVK 127
Cdd:PTZ00306   486 ghcdpglvkTLSVKsaDAISWLSSLGVPLTVlsqlggaSRKRCHRAPDKKDGTpvpigftiMRTLEdhIRTK--LSGRVT 563

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1676316597  128 IMYNKKVIDIITeEIALKDDSNKDKSKYLIKGIILDNGD----KILGDKVIISTGGVSYSKT 185
Cdd:PTZ00306   564 IMTETTVTSLLS-ESSARPDGVREIRVTGVRYKQASDASgqvmDLLADAVILATGGFSNDHT 624
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
3-60 3.78e-04

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 42.03  E-value: 3.78e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1676316597   3 KVIVVGGGASGMMAALSASKNNNEVILVERnGELgrklratgGGRCNFTNnrEIEDFF 60
Cdd:COG0492     2 DVVIIGAGPAGLTAAIYAARAGLKTLVIEG-GEP--------GGQLATTK--EIENYP 48
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
6-63 4.92e-04

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 38.28  E-value: 4.92e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1676316597   6 VVGGGASGMMAALSASKNNNEVILVERNGELG--------RKLRATGGGRCNFTNN-REIEDFFDKV 63
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGgnaysyrvPGYVFDYGAHIFHGSDePNVRDLLDEL 67
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-45 6.53e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 41.43  E-value: 6.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1676316597   1 MSKVIVVGGGASGMMAALSASKNNNEVILVERnGELGRklRATGG 45
Cdd:COG0665     2 TADVVVIGGGIAGLSTAYHLARRGLDVTVLER-GRPGS--GASGR 43
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-44 7.94e-04

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 41.08  E-value: 7.94e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1676316597   1 MSKVIVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATG 44
Cdd:COG0654     3 RTDVLIVGGGPAGLALALALARAGIRVTVVERAPPPRPDGRGIA 46
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 1-37 9.92e-04

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 41.37  E-value: 9.92e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1676316597   1 MSKVIVVGGGASGMMAALSASKNNNEVILVERNGELG 37
Cdd:COG1233     3 MYDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPG 39
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 3-40 1.91e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 36.80  E-value: 1.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1676316597   3 KVIVVGGGASGMMAALSASKNNNEVILVERNGELGRKL 40
Cdd:pfam00070   1 RVVVVGGGYIGLELAGALARLGSKVTVVERRDRLLPGF 38
PRK07233 PRK07233
hypothetical protein; Provisional
 3-37 3.03e-03

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 39.48  E-value: 3.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1676316597   3 KVIVVGGGASGMMAALSASKNNNEVILVERNGELG 37
Cdd:PRK07233    1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLG 35
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
4-32 3.48e-03

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 39.83  E-value: 3.48e-03
                          10        20
                  ....*....|....*....|....*....
gi 1676316597   4 VIVVGGGASGMMAALSASKNNNEVILVER 32
Cdd:PRK13800   16 VLVIGGGTAGTMAALTAAEHGANVLLLEK 44
PRK06134 PRK06134
putative FAD-binding dehydrogenase; Reviewed
 4-45 4.34e-03

putative FAD-binding dehydrogenase; Reviewed


Pssm-ID: 180419 [Multi-domain]  Cd Length: 581  Bit Score: 39.32  E-value: 4.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1676316597   4 VIVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATGG 45
Cdd:PRK06134   15 VLVIGSGAAGLSAAVTAAWHGLKVIVVEKDPVFGGTTAWSGG 56
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 3-40 5.39e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 38.45  E-value: 5.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1676316597   3 KVIVVGGGASGMMAALSASKNNNEVILVERNGELGRKL 40
Cdd:pfam07992 154 RVVVVGGGYIGVELAAALAKLGKEVTLIEALDRLLRAF 191
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
3-38 8.49e-03

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 38.40  E-value: 8.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1676316597   3 KVIVVGGGASGMMAA---LSASKNNNEVILVERNGELGR 38
Cdd:COG4529     7 RIAIIGGGASGTALAihlLRRAPEPLRITLFEPRPELGR 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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