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Conserved domains on  [gi|1676316603|emb|VHY01001|]
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g196 [Clostridioides difficile]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-314 7.67e-141

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17391:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 380  Bit Score: 403.18  E-value: 7.67e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYI 80
Cdd:cd17391    68 MLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  81 ESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESISiPKEQLNILPNKFLIASIFVTTFITQLALYSIEPIVTI 160
Cdd:cd17391   148 ADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVS-TKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTL 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 161 YISQLTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLS 240
Cdd:cd17391   227 YIRQLMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLA 306

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1676316603 241 VAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFMNALWMYKFT 314
Cdd:cd17391   307 TGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
 
Name Accession Description Interval E-value
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 1-314 7.67e-141

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 403.18  E-value: 7.67e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYI 80
Cdd:cd17391    68 MLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  81 ESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESISiPKEQLNILPNKFLIASIFVTTFITQLALYSIEPIVTI 160
Cdd:cd17391   148 ADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVS-TKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTL 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 161 YISQLTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLS 240
Cdd:cd17391   227 YIRQLMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLA 306

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1676316603 241 VAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFMNALWMYKFT 314
Cdd:cd17391   307 TGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
1-309 6.02e-73

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 230.96  E-value: 6.02e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYI 80
Cdd:PRK09874   86 MLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLL 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  81 ESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESISIpKEQLNILPNKFLIASIFVTTFITQLALYSIEPIVTI 160
Cdd:PRK09874  166 ADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPVSKKEMLHM-REVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTL 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 161 YISQLTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLS 240
Cdd:PRK09874  245 YVRELAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAA 324

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1676316603 241 VAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFMNALW 309
Cdd:PRK09874  325 DGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVY 393
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-275 8.56e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 105.06  E-value: 8.56e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTG-YATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:COG2814    77 VLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKeikeSISIPKEQLNILPNKFLIAsIFVTTFITQLALYSIEPIVT 159
Cdd:COG2814   157 LADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAA----RARLRGSLRELLRRPRLLL-LLLLAFLLGFGFFALFTYLP 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 160 IYISQLTNFAsnvALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGL 239
Cdd:COG2814   232 LYLQEVLGLS---ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGF 308

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1676316603 240 SVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIG 275
Cdd:COG2814   309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
1-280 3.23e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 78.23  E-value: 3.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTG-YATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:pfam07690  64 VLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKSTFIITGGLLFVSFIISILFVVdnfKPKEIKESISIPKEQLNILPNKFLIASIFVTTFITQLALYSIEPIVT 159
Cdd:pfam07690 144 LASLFGWRAAFLILAILSLLAAVLLLLPRP---PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLL 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 160 IYISQLTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGII---FIPQAFVKTAWQLMLLRFL 236
Cdd:pfam07690 221 TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAalgLLLLSLTLSSLWLLLALLL 300

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1676316603 237 LGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGA 280
Cdd:pfam07690 301 LGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 176-296 6.09e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 44.27  E-value: 6.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 176 AGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKI 255
Cdd:TIGR00895  54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEY 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1676316603 256 APEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVF 296
Cdd:TIGR00895 134 APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLF 174
 
Name Accession Description Interval E-value
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 1-314 7.67e-141

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 403.18  E-value: 7.67e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYI 80
Cdd:cd17391    68 MLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  81 ESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESISiPKEQLNILPNKFLIASIFVTTFITQLALYSIEPIVTI 160
Cdd:cd17391   148 ADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVS-TKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTL 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 161 YISQLTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLS 240
Cdd:cd17391   227 YIRQLMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLA 306

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1676316603 241 VAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFMNALWMYKFT 314
Cdd:cd17391   307 TGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
1-309 6.02e-73

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 230.96  E-value: 6.02e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYI 80
Cdd:PRK09874   86 MLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLL 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  81 ESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESISIpKEQLNILPNKFLIASIFVTTFITQLALYSIEPIVTI 160
Cdd:PRK09874  166 ADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPVSKKEMLHM-REVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTL 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 161 YISQLTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLS 240
Cdd:PRK09874  245 YVRELAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAA 324

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1676316603 241 VAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFMNALW 309
Cdd:PRK09874  325 DGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVY 393
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-313 4.26e-40

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 144.26  E-value: 4.26e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTG-YATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:cd17325    63 LLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESISIPKEQLNILPNKF-LIASIFVTTFITQLALYSIEPIV 158
Cdd:cd17325   143 LADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDrRLLALFLAIFVLAFAFGALEPFL 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 159 TIYISQLTNFasnVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLG 238
Cdd:cd17325   223 PLYAAELGGL---SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLG 299

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1676316603 239 LSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFMNALWMYKF 313
Cdd:cd17325   300 LGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-275 8.56e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 105.06  E-value: 8.56e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTG-YATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:COG2814    77 VLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKeikeSISIPKEQLNILPNKFLIAsIFVTTFITQLALYSIEPIVT 159
Cdd:COG2814   157 LADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAA----RARLRGSLRELLRRPRLLL-LLLLAFLLGFGFFALFTYLP 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 160 IYISQLTNFAsnvALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGL 239
Cdd:COG2814   232 LYLQEVLGLS---ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGF 308

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1676316603 240 SVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIG 275
Cdd:COG2814   309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 1-312 6.95e-21

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 91.49  E-value: 6.95e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYI 80
Cdd:cd17330    66 VLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFL 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  81 ESILGLKSTFIITGGLLFVSFIISILFVvdnfkpkeikesisipkeqlnilpnkFLIASIFVTTFITQLALYSIEPIVTI 160
Cdd:cd17330   146 STPYGYALPFLVAAALALLNLVLVLFFL--------------------------PPLRRLLLVYFLIALAFAGLESVFSL 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 161 YISQLTNFASNValiAGLTFSASGLANLLA-AQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGL 239
Cdd:cd17330   200 FLKDRFGFSPSQ---IGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAF 276

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1676316603 240 SVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFMNALWMYK 312
Cdd:cd17330   277 GTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-310 1.11e-16

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 79.52  E-value: 1.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACT-TLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:cd17324    66 LLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAaAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGL 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKSTFIITGGLLFVSFIISILFVVDNfkPKEIKESISIPKEQLNILPNKFLiASIFVTTFITQLALYSIEPIVT 159
Cdd:cd17324   146 LGQLLGWRAAFLAIAVLALLAALLLWRLLPSL--PPKKPGSLGLLSSLLLLLRNPRL-RLAYLITFLLFGGFFALYTYLA 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 160 IYISQLTNFASNVAliaGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGL 239
Cdd:cd17324   223 PFLTDVPGFSSSAI---IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGL 299

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1676316603 240 SVAGLNPSVNSLLKKIAPEEyVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFMNALWM 310
Cdd:cd17324   300 GFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
MFS_1 pfam07690
Major Facilitator Superfamily;
1-280 3.23e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 78.23  E-value: 3.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTG-YATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:pfam07690  64 VLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKSTFIITGGLLFVSFIISILFVVdnfKPKEIKESISIPKEQLNILPNKFLIASIFVTTFITQLALYSIEPIVT 159
Cdd:pfam07690 144 LASLFGWRAAFLILAILSLLAAVLLLLPRP---PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLL 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 160 IYISQLTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGII---FIPQAFVKTAWQLMLLRFL 236
Cdd:pfam07690 221 TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAalgLLLLSLTLSSLWLLLALLL 300

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1676316603 237 LGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGA 280
Cdd:pfam07690 301 LGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 1-313 3.86e-16

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 78.04  E-value: 3.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTG-YATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:cd06173    71 DLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAfFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGL 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKSTFIITGGLLFVS--FIISILFVVDNFKPKEIKESISIPKEQLNILPNKFLIASIFVTTFITQLALYSIEPI 157
Cdd:cd06173   151 LVALLGPGGAFAINALSFLLSalLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 158 VTIYISQLTNFAsnvALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLL 237
Cdd:cd06173   231 LPLLAKEVLGGG---AAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLL 307

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1676316603 238 GLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFMNALWMYKF 313
Cdd:cd06173   308 GLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 141-321 4.31e-16

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 78.07  E-value: 4.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 141 FVTTFITQLALYSIEPIVTIYISQLTNFA-SNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFI 219
Cdd:cd17391     2 WLGNFFTGIGFSLIAPFLPLYIEQLGVTSgGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 220 PQAFVKTAWQLMLLRFLLGLsVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFST 299
Cdd:cd17391    82 LMAFVTNVWQLLILRLLQGV-FSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFIT 160

                         170       180
                  ....*....|....*....|..
gi 1676316603 300 SLLLFMNALWmykfTGLFIKDK 321
Cdd:cd17391   161 GGLLFLAFLL----TLFFVKED 178
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-310 5.94e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 77.60  E-value: 5.94e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTG-YATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:COG2271    77 VLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKSTFIITGGLLFVSFIISILFvvdnfkpkeikesisipkeqlnilpnkfliasIFVTTFITQLALYSIEPIVT 159
Cdd:COG2271   157 LLAAFGWRAAFLILGLPGLLLALLRFWL--------------------------------LALAYFLVYFALYGFLTWLP 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 160 IYISQLTNFAsnvALIAGLTFSASGLANLLAAQKLGKMSDKIGPQK--VLLISLLWAGIIFIPQAFVKTAWQLMLLRFLL 237
Cdd:COG2271   205 TYLVEVRGLS---LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLA 281

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1676316603 238 GLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFMNALWM 310
Cdd:COG2271   282 GFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-305 2.78e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 75.69  E-value: 2.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTTLIATQ-TDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:COG2223    72 VLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKwFPPDRRGLALGLAAGGGNLGAAVAAFLAPL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESISIpKEQLNILPNK--FLIASIFVTTFITQLALYSIepI 157
Cdd:COG2223   152 LIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASL-RDQLEALRDPrfWLLSLLYFGTFGSFIGFSSW--L 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 158 VTIYISQLTNFASNVALIAGLTFSASGLANLLAaqklGKMSDKIGPQKVLLISLLWAGIIFIPQAFV-KTAWQLMLLRFL 236
Cdd:COG2223   229 PPYLVDQFGLSAATAGLLAALFALLGALGRPLG----GWLSDRIGGRRVLLIVFALMALGLLLLALAlGSLWLFLVLFLL 304

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1676316603 237 LGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYnasaQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFM 305
Cdd:COG2223   305 LGLALGGGNGAVFALVPDIFPTKNAGAVYGL----VGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFA 369
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-315 2.87e-13

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 69.55  E-value: 2.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGV-FTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:cd17489    63 LLLIGLLIFALATLLYLLATSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLF 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESISIPKEQL---NILPNKFLIASIFVT--TFITQLALYSI 154
Cdd:cd17489   143 LYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLvekKVLPPALILFLASIAygAISTFLPLYAA 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 155 EPIVTIyisqltnfasnvaliAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLR 234
Cdd:cd17489   223 ERGISN---------------AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAA 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 235 FLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFmNALWMYKFT 314
Cdd:cd17489   288 VLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVL-LALVLYIFL 366


                  .
gi 1676316603 315 G 315
Cdd:cd17489   367 L 367
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 17-308 1.58e-12

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 67.60  E-value: 1.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  17 AFVQNVYQLLGLRILQGVFTGYATACT-TLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESIlGLKSTFIITGG 95
Cdd:cd17474    82 GLSDSFALLLAGRALQGIGAAGLGPLAlTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAA 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  96 LLFVSFIIsILFVVDNFKPKEIKESISIPKEQLNILPNKfLIASIFVTTFITQLALYSIepivTIYISQ-LTNFASNVAL 174
Cdd:cd17474   161 LIPVAFLA-ILFLLPEPKEKAKSSSATKLRDLKKALRGR-GLLTFLVSAFLYFFLYFAF----LTYLPFlLELLYGISPI 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 175 IAGLTFSASGLANLLAAQKLGKMSDK-IGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLK 253
Cdd:cd17474   235 IIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVT 314

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1676316603 254 KIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFMNAL 308
Cdd:cd17474   315 ELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 140-313 1.67e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 67.22  E-value: 1.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 140 IFVTTFITQLALYSIEPIVTIYISQLtnfaSNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFI 219
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESL----GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 220 PQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFST 299
Cdd:cd17325    77 LFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156

                         170
                  ....*....|....
gi 1676316603 300 SLLLFMNALWMYKF 313
Cdd:cd17325   157 AALALLALVLALLL 170
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
134-313 9.28e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 65.00  E-value: 9.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 134 KFLIASIFVTTFITQLALYSIEPIVTIYISQLTNFASNVALIAGLTFSASGLANLLAaqklGKMSDKIGPQKVLLISLLW 213
Cdd:COG2814     9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLA----GRLADRFGRRRVLLLGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 214 AGIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIR 293
Cdd:COG2814    85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164

                         170       180
                  ....*....|....*....|
gi 1676316603 294 TVFFSTSLLLFMNALWMYKF 313
Cdd:COG2814   165 WVFLVNAVLALLALLLLLRL 184
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 9-300 1.33e-11

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 64.50  E-value: 1.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   9 MGIVIFT-----MAFVQNVYQLLGLRILQGVFTGYATACTT-LIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIES 82
Cdd:cd17321    66 IGLALFGlasllCALAPSLAFLIAARALQGIGAAAIMPASLaLIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  83 ILGLKSTFIITGGLLFVSFIISILFVVDNfkpkeikesisipkeqlnilpnkfliasifVTTFITQLALYSIEPIVTIYI 162
Cdd:cd17321   146 LFGWRWIFLINVPIGLVALLLARTFSGAV------------------------------LAAFLLGAALGGLLFLLPLYL 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 163 SQLTNFAsnvALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTA---WQLMLLRFLLGL 239
Cdd:cd17321   196 QGVLGYS---PLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADssvWLLLPGLVLLGL 272

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1676316603 240 SVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCS-----SGAFLGGQISAHLGIRTVFFSTS 300
Cdd:cd17321   273 GLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGAlgvalLGALLTAGLSANLGDSGVAALLS 338
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 2-311 1.73e-11

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 64.13  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   2 LLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTG-YATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYI 80
Cdd:cd17473    68 LIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAgIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  81 ESIlGLKSTFIITGgLLFVSFIISILFVvdnFKPKEIKESISIPKEQLNILPNKFLIASIFVTTFITQLALYSIepivTI 160
Cdd:cd17473   148 AEI-GWRAPFLVYL-LALPVLILVLLFL---PEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVI----PI 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 161 YISQ-LTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGL 239
Cdd:cd17473   219 QLPFlLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGL 298

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1676316603 240 SVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQIS-AHLGIRTVFFSTSLLLFMNALWMY 311
Cdd:cd17473   299 GFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVnLTGGLSGAFLILGVLALVLAIVLL 371
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 7-302 4.87e-11

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 63.00  E-value: 4.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   7 IGMGIVIFTM-----AFVQNVYQLLGLRILQGvfTG-YATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYI 80
Cdd:cd17472    65 ILFGLLLFIAgsllaAYATSIYGLILGRALQG--SGaISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  81 ESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESIsiPKEQLNILPNKFLIaSIFVTTFITQLALYSIEPIVTI 160
Cdd:cd17472   143 AAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKE--KKKLKKLLKNKRLL-RLDFSIFILHFVLMAFFYILPL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 161 YISQLTNFASNVALIAGLTFSASGLANLLA---AQKLGKMSdkigpqKVLLISLLWAGIIFIPQAFVKT-AWQLMLLRFL 236
Cdd:cd17472   220 LLTQLGGGKGQLWKVYLPAILIGFILMVPFviyAEKKGKMK------QVFVSSILLIAVGFLLLLFAATsLWLLIIGLII 293

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1676316603 237 LGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLL 302
Cdd:cd17472   294 FFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILIL 359
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 1-313 5.85e-11

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 62.63  E-value: 5.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTG-YATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:cd17329    67 VMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IeSILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESISIPKEQLNILPNKFLIAsIFVTTFITQLALYSIEPIVT 159
Cdd:cd17329   147 L-LLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLL-FLLASFLISLIYFQLESTLP 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 160 IYISQLTNFASNvalIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGL 239
Cdd:cd17329   225 VYVVEILGLGES---LLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTL 301

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1676316603 240 SVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFMNALWMYKF 313
Cdd:cd17329   302 GEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-308 7.26e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 62.44  E-value: 7.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTG-YATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:cd06174    63 VLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGI 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 I--ESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESISIPKEQLNILPNKFL---IASIFVTTFITQLALYSI 154
Cdd:cd06174   143 LasSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKnpgLWLLLLAIFLVNLAYYSF 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 155 EPIVTIYISQLTNFASNVALIAGLTFSASGLANLLAAQKLgkMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLR 234
Cdd:cd06174   223 STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLL--SDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLL 300

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1676316603 235 FLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQI-SAHLGIRTVFFSTSLLLFMNAL 308
Cdd:cd06174   301 LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAI 375
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 1-224 9.26e-11

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 62.21  E-value: 9.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYAT-ACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:cd17503    63 LFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIpLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGW 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKStfiitggllfvSFIISILFVVDNFkpkeikesISIPKEQLNILPNKFLIASIfVTTFITQLALYSIEPIVT 159
Cdd:cd17503   143 LTDNLSWRW-----------IFYINLPIGILAL--------LLAPLLDLRLFKDRNFTLGL-LLSFLLGLGLFGAMFLLP 202

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1676316603 160 IYISQLTNFAsnvALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFV 224
Cdd:cd17503   203 LYLQNVLGYS---AFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFL 264
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 44-309 4.80e-10

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 59.93  E-value: 4.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  44 TLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESISI 123
Cdd:cd17331   109 MVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEAKES 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 124 PKEQLNILPNKFL-------IASIFVTTFITQLALYSIEPIVTIYISQLTNFASNVAliaGLTFSASGLANLLA-AQKLG 195
Cdd:cd17331   189 ASPPSVFNLKEILrllrlpgVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEEN---GYLMSYAGVLGMVVqGLLVG 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 196 KMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIG 275
Cdd:cd17331   266 PLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLV 345

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1676316603 276 CSSGAFLGGQISAHLGIRTV-FFSTSLLLFMNALW 309
Cdd:cd17331   346 RTVSPTIGGALLQAYGFPSFgLLGAAINGLLTVYL 380
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
145-321 5.75e-09

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 56.85  E-value: 5.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 145 FITQLALYSIEPIVTIYISQL-TNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAF 223
Cdd:PRK09874   24 FLTGAAFSLVMPFLPLYVEQLgVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 224 VKTAWQLMLLRFLLGLsVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLL 303
Cdd:PRK09874  104 AQNIWQFLILRALLGL-LGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVL 182

                         170
                  ....*....|....*...
gi 1676316603 304 FMnalwMYKFTGLFIKDK 321
Cdd:PRK09874  183 FL----CFLVTLFCIREN 196
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-108 8.02e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.05  E-value: 8.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTG-YATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:cd17325   267 LILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGlVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF 346

                          90       100
                  ....*....|....*....|....*....
gi 1676316603  80 IESILGLKSTFIITGGLLFVSFIISILFV 108
Cdd:cd17325   347 LYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_1 pfam07690
Major Facilitator Superfamily;
140-314 8.18e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 56.27  E-value: 8.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 140 IFVTTFITQLALYSIEPIVTIYISQLTNFASNVAliaGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFI 219
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEI---GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 220 PQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFST 299
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170
                  ....*....|....*
gi 1676316603 300 SLLLFMNALWMYKFT 314
Cdd:pfam07690 158 AILSLLAAVLLLLPR 172
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 10-212 1.42e-08

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 55.66  E-value: 1.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  10 GIVIFT-----MAFVQNVYQLLGLRILQGVFTGYATACT-TLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESI 83
Cdd:cd17320    70 GLLLFIlasllCALASSIEQLLIARFLQGLGAAAGSVVArAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLF 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  84 LGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESIS-IPKEQLNILPNKFLIASIFVTTFITQ--LALYSIEPIVTI 160
Cdd:cd17320   150 FGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSsLLRAYKRVLKNRRFLGYALALGLSFAglFAYLAAAPFIYI 229

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1676316603 161 YISQLTnfasnvALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLL 212
Cdd:cd17320   230 EQLGLS------PAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLL 275
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
2-313 1.80e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 55.29  E-value: 1.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   2 LLRASIGMGIVIFTMAFVQN-------VYQLLGLRILQGVFTGYATACTTLIATQTDKNH-----SGWALGTLATASTTG 69
Cdd:COG2211    84 ILIGAIPLALSFVLLFTAPDlsptgklIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEertrlSSWRFAFAGLGGLLA 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  70 SLIGPTVGGYI--ESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESIsipKEQL-NILPNKFLIAsIFVTTFI 146
Cdd:COG2211   164 SVLPPPLVAAFggDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSL---KESLkALLKNRPFLL-LLLAYLL 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 147 TQLALYSIEPIVTIYIsqlTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKT 226
Cdd:COG2211   240 FFLALALVAALLLYYF---KYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGP 316

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 227 A--WQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYV-------GKIFGYNASAQYIGCSSGAFLGGQI----------- 286
Cdd:COG2211   317 GnlWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLlalfgyvagaa 396

                         330       340       350
                  ....*....|....*....|....*....|
gi 1676316603 287 ---SAHLGIRTVFFSTSLLLFMNALWMYKF 313
Cdd:COG2211   397 qspSALTGIRLLFFLLPAVLLLLAALLLLF 426
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
135-310 1.99e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.88  E-value: 1.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 135 FLIASIFVTTFITQLALYSIEPIVTIYISQLTNFASNVALIAGLTFSASGLANLLAaqklGKMSDKIGPQKVLLISLLWA 214
Cdd:COG2271    10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPA----GLLADRFGRRRVLAIGLLLW 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 215 GIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRT 294
Cdd:COG2271    86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165

                         170
                  ....*....|....*.
gi 1676316603 295 VFFSTSLLLFMNALWM 310
Cdd:COG2271   166 AFLILGLPGLLLALLR 181
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 140-308 2.24e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 54.91  E-value: 2.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 140 IFVTTFITQLALYSIEPIVTIYISQLTNFASNVALIAGLTFSASGLANLLAaqklGKMSDKIGPQKVLLISLLWAGIIFI 219
Cdd:cd17489     1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFA----GRLLDRFGRKRLLLIGLLIFALATL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 220 PQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFST 299
Cdd:cd17489    77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156


                  ....*....
gi 1676316603 300 SLLLFMNAL 308
Cdd:cd17489   157 AVLALLALL 165
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 1-288 6.64e-08

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 53.35  E-value: 6.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYI 80
Cdd:cd17504    63 VLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWI 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  81 ESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEikesisipkeqlnilpnkflIASIFVTTFITQLALYSIEPIVTI 160
Cdd:cd17504   143 VQHLGWRWIFWTAAPVAVLLAALVPLIDLRLLRRRN--------------------VLLANITALLAGFGMFMVFQLLPQ 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 161 YISQLTNFASNV-ALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTA-WQLMLLRFLLG 238
Cdd:cd17504   203 LLQLPTPTGFGLgITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSlWALVVALLLIG 282

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1676316603 239 LSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISA 288
Cdd:cd17504   283 IGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILT 332
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 16-311 1.80e-07

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 52.22  E-value: 1.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  16 MAFVQNVYQLLGLRILQGVFTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESILGLKSTFIITGG 95
Cdd:cd17490    79 MILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAAL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  96 LLFVSFIISILFVvdnfKPKEIKESISIP-KEQLNILPNKFLIASIFVTTFITQLALYSIEPIVTIYISQLTNFASNVAL 174
Cdd:cd17490   159 AGVLGFILSLFIK----EERREKKPVLTElKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGL 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 175 IAGLTFSASGLANLLAAQKLGKmsdKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKK 254
Cdd:cd17490   235 LSIIYLLPNALASLLSGTLFYK---KLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIE 311

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 255 IAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFF---STSLLLFMNALWMY 311
Cdd:cd17490   312 GVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFvigVIALLAAILSLAYY 371
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-191 9.28e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 49.42  E-value: 9.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACT-TLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:COG0477    81 VLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGAlALIAELFPARERGRALGLWGAAIGLGLALGPLLGGL 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKSTFIITGGLLFVSFIisILFVVDNFKPKEIKESISIPKEQLNILPNKFLIASIFVTTFITQLALYSIEPIVT 159
Cdd:COG0477   161 LVAALGWRWIFLINAPLGLLALV--LRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAA 238

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1676316603 160 IYISQLTNFASNVALIAGLTFSASGLANLLAA 191
Cdd:COG0477   239 LLLLLALLLLALLLLLALLLLAALLLLLLLLL 270
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 134-313 1.31e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 49.04  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 134 KFLIASIFVTTFITQLALYSIEPIVTIYISQLTNFASNVALIAGLTFSASGLANLLAaqklGKMSDKIGPQKVLLISLLW 213
Cdd:COG0477    13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLF----GRLGDRYGRKRVLLIGLLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 214 AGIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIR 293
Cdd:COG0477    89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168

                         170       180
                  ....*....|....*....|
gi 1676316603 294 TVFFSTSLLLFMNALWMYKF 313
Cdd:COG0477   169 WIFLINAPLGLLALVLRLRL 188
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 140-309 1.78e-06

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 49.17  E-value: 1.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 140 IFVTTFITQLALYSIEPIVTIYISQLTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFI 219
Cdd:cd17388     4 ILVTVLLDAMGIGLIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 220 PQAFVKTAWQLMLLRFllglsVAGLNPSV----NSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGqISAHLGIRTV 295
Cdd:cd17388    84 LMAFAPTLWWLYLGRI-----IAGITGATgavaAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGG-LLGEISPRAP 157

                         170
                  ....*....|....
gi 1676316603 296 FFSTSLLLFMNALW 309
Cdd:cd17388   158 FLVAAGLNGLNFLL 171
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 12-108 2.07e-06

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 48.73  E-value: 2.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  12 VIFTM--AFVQNVYQLLGLRILQGVF--TGYATACTTlIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESILGLK 87
Cdd:cd17323    75 VIFQIgcALAPNIAMLIILRFLQGFFgsSPLAIGAGT-IADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWR 153

                          90       100
                  ....*....|....*....|.
gi 1676316603  88 STFIITGGLLFVSFIISILFV 108
Cdd:cd17323   154 WIFWFLAIISGFCLILIFLFL 174
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 14-228 3.79e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 47.92  E-value: 3.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  14 FTMAFVQNVYQLLGLRILQGVFTGYATACT-TLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESILGL--KSTF 90
Cdd:cd17370    80 PLLALAGSWQLVLLLRILERLGKGIRTPPRdALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGnyRTIF 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  91 IITGGLLFVSFIIsILFVVDNfKPKEIKESISIPKEQLNILPNKFLIASIFVttFITQLALYSiepiVTIYISQLTNFAS 170
Cdd:cd17370   160 LLAAIPALLALLI-LLFVVKE-YPRPPKLRKKSKKTSLKKLPKAFWLYLLAV--ALFALGNFS----FAFLILRAQELGL 231

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1676316603 171 NVALIAgLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAW 228
Cdd:cd17370   232 SAALIP-LLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLW 288
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 140-311 8.17e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.84  E-value: 8.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 140 IFVTTFITQLALYSIEPIVTIYISQLTNFAsnvALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFI 219
Cdd:cd17329     4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLS---ASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 220 PQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGqISAHLGIRTVFFST 299
Cdd:cd17329    81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGG-LLLLYSFRLLFLAA 159

                         170
                  ....*....|..
gi 1676316603 300 SLLLFMNALWMY 311
Cdd:cd17329   160 AVLFLLAALVLL 171
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 7-220 9.25e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 46.85  E-value: 9.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   7 IGMGIVIFTMA-----FVQNVYQLLGLRILQGV-FTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYI 80
Cdd:cd17328    67 LAVGILIWSAAtllssFAPNFWQLLLFRALVGIgEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLV 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  81 -ESILGLKSTFIITGGLLFVSFIISILFVVDN------FKPKEIKESISIPKEQLNILPNK-FLIASI-FVTTFITQLAL 151
Cdd:cd17328   147 aQATGGWRWAFRVTGVLGVLLAILLLLFVREPprgaaeGGVMAKSTATSFLADLKALAKNPsFILSTLgFTAVSFVTGAL 226

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1676316603 152 -YSIEPIVTIYISQLTNFASNVALIAGLTFSASGLANLL----AAQKLGKMSDKIGPqKVLLISLLWAGIIFIP 220
Cdd:cd17328   227 aFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLlggiLADRLRRKTPRADP-LVCAVGLLAAAPFLFL 299
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 56-266 3.64e-05

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 45.14  E-value: 3.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  56 GWALG----TLATASTTGSLIGPTVGGYIESILGLKSTFIITGGLLFVSFIISILFVVDNFKP-------------KEIK 118
Cdd:COG2270   149 GWALGylggVLLLLINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPgpapprgavragfRELR 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 119 ESISIPKEQLNILpnKFLIASifvttFITQLALYSIEPIVTIYISQLTNFASNVALIAGLTFSASGLanlLAAQKLGKMS 198
Cdd:COG2270   229 RTLRELRRYRDLL--RFLLAY-----FFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAA---LGALLFGRLD 298

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1676316603 199 DKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFG 266
Cdd:COG2270   299 DRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFG 366
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 5-308 3.75e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 44.95  E-value: 3.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   5 ASIGMGIVIFTMAFVQNVYQLL---GLRILQGVFTGYATACTTLIATQTDKNHsGWALGTLATASTTGSLIGPTVGGYIE 81
Cdd:cd17355    74 GLLLLAAGLVLLALATSLWQLYllwGLLGGGGAGTLAAVAFATVAAWWFERRR-GLALGILTAGGGLGSLVFLPLGAALI 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  82 SILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEiKESISIPKEQLNILPNKFLIAS-----IFVTTFITQLALYSiep 156
Cdd:cd17355   153 EAFGWRTALLVLALLALLVLVPVLLLLRRRPADLA-LRAYDDASPASPGSTLKEALRSasfwlLALAFFLCGFAVVG--- 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 157 IVTIYISQLTNFASNVALiAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGI-IFIPQAFVKTAWQLMLLRF 235
Cdd:cd17355   229 LIVHLVPYLADRGISPAA-AAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALgLALLLLLPFPPLALLLFAA 307

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1676316603 236 LLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLG-IRTVFFSTSLLLFMNAL 308
Cdd:cd17355   308 LFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAAL 381
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 139-313 4.78e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 44.46  E-value: 4.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 139 SIFVTTFITQLALYSIEPIVTIyISQltNFASNVALiAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIF 218
Cdd:cd17324     3 ALALAAFAIGTTEYVIQGLLPD-IAR--DFGVSVAQ-AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 219 IPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFS 298
Cdd:cd17324    79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA 158

                         170
                  ....*....|....*
gi 1676316603 299 TSLLLFMNALWMYKF 313
Cdd:cd17324   159 IAVLALLAALLLWRL 173
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 176-296 6.09e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 44.27  E-value: 6.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 176 AGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKI 255
Cdd:TIGR00895  54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEY 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1676316603 256 APEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVF 296
Cdd:TIGR00895 134 APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLF 174
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 2-270 8.93e-05

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 43.78  E-value: 8.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   2 LLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIE 81
Cdd:cd17388    71 LLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLG 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  82 SIlGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESIS---IPKEQLNILPNKFLIASIFVTTFITQLALYSIEPIV 158
Cdd:cd17388   151 EI-SPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWrraNPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTW 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 159 TIYISQltNFASNVALIaGLTFSASGLANLLA-AQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLL 237
Cdd:cd17388   230 VLFTED--RFDWSPTMV-GLSLAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILL 306

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1676316603 238 GLSVAGLnPSVNSLLKKIAPEEYVGKIFGYNAS 270
Cdd:cd17388   307 ALGGIAG-PALQGLLSRQVPENEQGELQGVLTS 338
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 1-109 1.15e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 43.37  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYI 80
Cdd:cd17390    63 VLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHL 142

                          90       100
                  ....*....|....*....|....*....
gi 1676316603  81 ESilglkstfiITGGLLFVSFIISILFVV 109
Cdd:cd17390   143 AE---------TDGGFYYVALLCSAIFIL 162
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 90-302 1.47e-04

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 42.96  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  90 FIITGGLLFVSFIISILFvvdNFKPKEIKESISIpKEQLNILPNKFLIASIFVTTFItQLALYSIEPIVTIYISQLTnfA 169
Cdd:cd17335   158 FYVFAVLMLLALLLALKF---PFRPKHPEPNENT-GGLLALLRNPRVLAFLLVAFLM-GFGHGLIYSFLFWHLQDLG--G 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 170 SNVALiaGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVN 249
Cdd:cd17335   231 SKTLI--GLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAV 308

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1676316603 250 SLLKKIAPEEYVGKIFG-YNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLL 302
Cdd:cd17335   309 SYASAAAPPGLRATAQGlLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIA 362
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 2-103 1.56e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.92  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   2 LLRASIGMGIVIFT-MAFVQNVYQLLGLRILQGVFTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYI 80
Cdd:cd17471   267 LLLAGFLAGVLFYLgLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVI 346

                          90       100
                  ....*....|....*....|...
gi 1676316603  81 ESILGLKSTFIITGGLLFVSFII 103
Cdd:cd17471   347 AQYFGYRAVFLVCAVLALLALVL 369
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-305 1.70e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 1.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYA-TACTTLIATQTDKN--------HSGWALGTLATASTTGSL 71
Cdd:COG0738    75 GLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLdVAANPYVAALGPETaasrlnllHAFFSLGALLGPLLGGLL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  72 IGPTVGgyiesiLGLKSTFIITGGLLFVSFIISILFVVDNFKPKEiKESISIPKEQLNILPNKFLIAsIFVTTFITQLAL 151
Cdd:COG0738   155 ILLGLS------LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEE-EEAAGSAASLKSLLKNPRLLL-GGLAIFLYVGAE 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 152 YSIEPIVTIYISQLTNFASNVALIAGLTFSASGLANLLAAqklGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLM 231
Cdd:COG0738   227 GAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLG---GFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLAL 303

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1676316603 232 LLRFLLGLSVAGLNPSVNSLLKKIAPeEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFM 305
Cdd:COG0738   304 IGLALVGLGLSLMFPTIFSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLL 376
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
177-314 1.76e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.95  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 177 GLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIA 256
Cdd:COG2223    43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWF 122

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1676316603 257 PEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLFMNALWMYKFT 314
Cdd:COG2223   123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFL 180
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 1-304 2.28e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.59  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTG--YATAcTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGG 78
Cdd:cd17316    68 ALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGgeYPGA-STYVAEFAPSKRRGFALGLLQSGWALGALLAALVAS 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  79 YIESILGL----KSTFIITGGLLFVSFIISILFVVdnfkpkeikesisipkeqlnilpnkfliasIFVTTFITQLALYSI 154
Cdd:cd17316   147 LLIPLLSGdwgwRILFLIGALPALLALLLRRRTLL------------------------------LILLWFFISFGYYGL 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 155 EPIVTIYISQLTNFASNVALIAGLTFSASGLANLLAAqklGKMSDKIGPQKVLLISLLWAGIIFIP--QAFVKTAWQLML 232
Cdd:cd17316   197 TTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIA---GLLSDRIGRKKTLVIGLILSGILALPlfYLLSGSPTLLLL 273

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1676316603 233 LRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLLLF 304
Cdd:cd17316   274 LLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLA 345
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 140-313 2.45e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 42.18  E-value: 2.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 140 IFVTTFITQLALYSIEPIVTIYIsQLTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFI 219
Cdd:cd17330     1 LFLVVFLDALGFGIVFPVLPFYV-REFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 220 PQAFVKTAWQLMLLRFLLGLSvAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFST 299
Cdd:cd17330    80 LLGLSRNLWLLFLARFLDGLT-GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVA 158

                         170
                  ....*....|....
gi 1676316603 300 SLLLFMNALWMYKF 313
Cdd:cd17330   159 AALALLNLVLVLFF 172
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 145-313 3.61e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.03  E-value: 3.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 145 FITQLALYSIEPIVTIYISQLTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFV 224
Cdd:cd06174     2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 225 KTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGI--RTVFFSTSLL 302
Cdd:cd06174    82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwRAVFLIAAAL 161

                         170
                  ....*....|.
gi 1676316603 303 LFMNALWMYKF 313
Cdd:cd06174   162 ALLAAILLLLV 172
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 177-309 5.25e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 41.40  E-value: 5.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 177 GLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIA 256
Cdd:cd17319    41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1676316603 257 PEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLGIRTVFFSTSLL-LFMNALW 309
Cdd:cd17319   121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLgLLLAVLW 174
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 1-291 5.74e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 41.02  E-value: 5.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVF-TGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:cd17319    70 VLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAeAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGW 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKSTFIITGgllFVSFIISILFVVdnfkpkeikesisipkeqlnILPNKFLIASIFvttFITQLALYSIEPIVT 159
Cdd:cd17319   150 LLLLFGWRWAFIIEG---LLGLLLAVLWWF--------------------YLRQVWGLALGY---FGINYALYGLLTWLP 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 160 IYISQLTNF-ASNVALIAGLTFSASGLANLLAaqklGKMSDKIGPQ---KVLLISLLWAGIIFIPQAFVKTAWQLMLLRF 235
Cdd:cd17319   204 TYLKQARGFsLKQVGLLAAIPFLAGAIGMILG----GRLSDRLLRGarrLVIIIGLLLAAVGLLLAYLTTSPVVAVILLS 279

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1676316603 236 LLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHLG 291
Cdd:cd17319   280 LAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATG 335
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 5-226 6.76e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.00  E-value: 6.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   5 ASIGMGIVIFTMAFVQNVYQLLGLRILQGV-FTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESi 83
Cdd:cd17477    67 GAAITAVSVLLLALTDSPWVWFLLRFVMGIgLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGT- 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  84 lGLKSTFIITGGLLFVSFIIsILFVVDNFKPKEIKESISIPKEqlnILPNKFLIASIFVTTFITQlALYSIEPIvtiYIS 163
Cdd:cd17477   146 -AGALPFLIAAVLLLLALVP-LLLTRRAAPEIEEAESISLRRL---LRIAPLALLGAFVAGFLEG-AFYSLLPL---YGL 216

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1676316603 164 QLTNFASNVALIagltFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKT 226
Cdd:cd17477   217 RLGLSVAQAALL----LAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPG 275
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-113 7.08e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.01  E-value: 7.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFT-GYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:COG2271   250 VLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGY 329

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1676316603  80 IESILGLKSTFIITGGLLFVSFIISILFVVDNFK 113
Cdd:COG2271   330 LLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 5-222 1.03e-03

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 40.25  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   5 ASIGMGIVIFTMAFVQNVYQLLGLRILQGVftgyATACTT-----LIATQTDKNHS-----GWALGTLATasttGSLIGP 74
Cdd:cd17384    67 GFVIMFISTLLFAFGESYGVLFLARALQGV----GSACSSvagmgMLASLYPDDKErgkamGIALGGLAL----GVLVGP 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  75 TVGGYIESILGLKSTFIITGGLLFVSFIISILFVVDNFKPKEIKESISIpkeqLNILPNKFLIASIFVTTFITqLALYSI 154
Cdd:cd17384   139 PFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEGTPW----KTLLKDPYILIAAGAICFSN-SGIAIL 213

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 155 EPIVTIYISQLTNfASNVALiaGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGI--IFIPQA 222
Cdd:cd17384   214 EPCLPIWMMETMC-PPKWQL--GTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSLLGMLLVGIslILIPLA 280
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 28-217 1.31e-03

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 40.28  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  28 LRILQGV-FTGYATACTTLIAtQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESILGLKSTFIITGGLLFVSFIISIl 106
Cdd:cd17385   100 VRIVEAVgFAAFITASFAIIA-KEFPNNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNM- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 107 FVVDNFKPKEIKESISIPKeQLNILPNKFLIASIFVTTFitqlALYSIEPIVTIYISQltnFASNVALIaGLTFSASGLA 186
Cdd:cd17385   178 FILPRYDDDPSPKSGSMLK-LLKIPSVLLLCLSIVSGSV----SLGFLDPTLSPHLRQ---FKLSPGQV-GLMFLILAGS 248

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1676316603 187 NLLAAQKLGKMSDKIGPQKVLLISLLWAGII 217
Cdd:cd17385   249 YAISAPLWGWLSDKKKIPKWLMVIGSIITGV 279
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 9-228 1.33e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 40.23  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   9 MGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESILGLKS 88
Cdd:cd17478    71 TGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLG 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  89 TFIITGGLLFVSFIIsiLFVVDNFKPKEIKESISIPKEQLNILPNKFLIASIFVTTFITQLALYSIEPIVTIYISQLTNF 168
Cdd:cd17478   151 LLILLIIPGLAVALL--LLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYS 228

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 169 ASNVALIAGLTFSASGLANLLAaqklGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAW 228
Cdd:cd17478   229 LVFAGLLLSLFLFAGAIGTLIG----GPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIW 284
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 7-218 1.51e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 40.05  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   7 IGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYA-TACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESIL- 84
Cdd:TIGR00881  68 ILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGwPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELy 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  85 GLKSTFIITGGL-LFVSFIISILFVVDNFKPK----------------EIKESISIPKEQL--NILPNKFLIASIFVTTF 145
Cdd:TIGR00881 148 SWHWVFIVPGIIaIIVSLICFLLLRDSPQSCGlppaeempneepdgdaEKKEEELTKKQIFlqYVLLNKVLWYISLGYVF 227

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1676316603 146 iTQLALYSIEPIVTIYISQLTNFASNVALIAGLTFSASGLANLLAAqklGKMSDKI--GPQKVLLISLLwAGIIF 218
Cdd:TIGR00881 228 -VYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLA---GWLSDKLfnGRRGPLAVFFM-ALIIV 297
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 135-318 2.38e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.12  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 135 FLIASIFVTTFITQLALYSIepiVTIYISQLTNFASNvALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWA 214
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGF---VAPVLAAEFSLGLS-LLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 215 GIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFLGGQISAHL---- 290
Cdd:cd17316    77 GLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdw 156

                         170       180
                  ....*....|....*....|....*...
gi 1676316603 291 GIRTVFFSTSLLLFMnALWMYKFTGLFI 318
Cdd:cd17316   157 GWRILFLIGALPALL-ALLLRRRTLLLI 183
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 7-108 3.90e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 38.74  E-value: 3.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   7 IGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYA-TACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESILG 85
Cdd:cd17490   269 LLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILfPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG 348

                          90       100
                  ....*....|....*....|...
gi 1676316603  86 LKSTFIITGGLLFVSFIISILFV 108
Cdd:cd17490   349 LQTGFFVIGVIALLAAILSLAYY 371
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 1-111 4.22e-03

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 38.38  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTTLIATQT-DKNHSGWALGTLATASTTGSLIGPTVG-- 77
Cdd:cd17327    73 WLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWyKREEQAKRIAFFYAAAGLGSIFGGLLAyg 152

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1676316603  78 -GYIESILGLKS---TFIITGGLLFVSFIISILFVVDN 111
Cdd:cd17327   153 vFKILGVGGLAGwrwLFIIEGLITIIIGLVIFFWLPDN 190
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 5-103 4.50e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.32  E-value: 4.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   5 ASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTG-YATACTTLIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESI 83
Cdd:cd17474   271 GLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGlNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEI 350

                          90       100
                  ....*....|....*....|
gi 1676316603  84 LGLKSTFIITGGLLFVSFII 103
Cdd:cd17474   351 FGLSAPFLVGAAIALAAAVL 370
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 1-310 4.69e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 38.37  E-value: 4.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   1 MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTT-LIATQTDKNHSGWALGTLATASTTGSLIGPTVGGY 79
Cdd:cd17475    63 VLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGrAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPP 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603  80 IESILGLKSTFIITGGLLFVSFIISILFVVD-----------NFKPKEIKESISIPKEQLNILPNKFLIASIFVttFITQ 148
Cdd:cd17475   143 LALHYGWRAAFVVAGLVSILAAVLFWLFYREppaasaatesaSTLLRSLKEVLRNRDVWLIAIAGALLVAPQFA--LLTF 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 149 LALYSIEpivtiyisqltNFASNVALIAGLtFSASGLANLLAAQKLGKMSDKIGPQ---KVLLISLLWAGIIFIPQAFVK 225
Cdd:cd17475   221 LLLFLHD-----------HLGLSVVAAGAL-LAVAQLGGALGRIGLGRVSDRVFGGrrrPVLVITAAIAAAALLVLSLLS 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 226 ---TAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGCSSGAFL-GGQISAHLGIRTVFFSTSL 301
Cdd:cd17475   289 pgtPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLfGLLVDATHSYAPAWLALAL 368


                  ....*....
gi 1676316603 302 LLFMNALWM 310
Cdd:cd17475   369 LLVLAALLL 377
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 17-71 5.24e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 38.44  E-value: 5.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1676316603  17 AFVQNVYQLLGLRILQGV-FTGYATACTTLIATQTDKNHSGWALGTLATASTTGSL 71
Cdd:cd17371    82 GFAQNYWQLLILRALAGLgFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWL 137
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 195-298 6.20e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 38.05  E-value: 6.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 195 GKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYI 274
Cdd:cd17371    55 GILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAV 134

                          90       100
                  ....*....|....*....|....*...
gi 1676316603 275 GCSSGAFLGGQI----SAHLGIRTVFFS 298
Cdd:cd17371   135 GWLLATLLAALLfpllPPEIAWRVLFLL 162
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 9-107 6.31e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 37.97  E-value: 6.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603   9 MGIVIFTMAFVQNVYQLLGLRILqGVFTGYATACTTLIATQTDK---NHSGWALGTLATASTTGSLIGPTVGGYIESILG 85
Cdd:cd17353   289 QGVAMFLLPFIGSVAVLFVLGVA-LIGFCYGGGFALFPALTADFfgtKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGG 367

                          90       100
                  ....*....|....*....|..
gi 1676316603  86 LKSTFIITGGLLFVSFIISILF 107
Cdd:cd17353   368 YNAAFIIAAALSLVALALALLL 389
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 194-297 9.51e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 37.54  E-value: 9.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676316603 194 LGKMSDKIGPQKVLLISLLWAGIIFIPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQY 273
Cdd:cd17321    51 AGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVG 130

                          90       100
                  ....*....|....*....|....
gi 1676316603 274 IGCSSGAFLGGQISAHLGIRTVFF 297
Cdd:cd17321   131 IGAALGPLLGGLLLELFGWRWIFL 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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