|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
227-577 |
1.18e-88 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 279.13 E-value: 1.18e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 227 INALSEQMSKVYRAYTTTEEQLYTLLNELMIGVFLIDSESHLRLLNPKMQAHLGVHDYQPNQRYTEIIQEPKLIQLIHQV 306
Cdd:COG5002 33 LLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 307 TPNEPLIHQEITISEGQQTLDISLRYFNSSEETGQILGVAYDLTKVRRLEKLQKDFVGNVSHELKTPVTSLIGFTETLLD 386
Cdd:COG5002 113 LLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLD 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 387 GAKDDPKILNEFLLIMQKDAIRLDKLIREIIQLSKDEETAH--ETQTIHLATYFEQIIQSYQPMIEKKHLTLEMQQKEQS 464
Cdd:COG5002 193 GAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELklEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDP 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 465 FTTQ--TELLYPIIKNLIENAIQYSKESEKIIIR-YEVDNQLTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTG 541
Cdd:COG5002 273 LLVLgdPDRLEQVLTNLLDNAIKYTPEGGTITVSlREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTG 352
|
330 340 350
....*....|....*....|....*....|....*.
gi 1672584895 542 LGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIPPA 577
Cdd:COG5002 353 LGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLA 388
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
258-574 |
1.34e-74 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 240.57 E-value: 1.34e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 258 GVFLIDSESHLRLLNPKMQAHLGVHdyQP---NQRYTEIIQEPKLIQLIHQVTPNEPLIHQEITISEgqqtLDISLRYFN 334
Cdd:TIGR02966 18 AVVVLDEEGQIEWCNPAAERLLGLR--WPddlGQRITNLIRHPEFVEYLAAGRFSEPLELPSPINSE----RVLEIRIAP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 335 SSEEtgQILGVAYDLTKVRRLEKLQKDFVGNVSHELKTPVTSLIGFTETLLDGAKDDPKILNEFLLIMQKDAIRLDKLIR 414
Cdd:TIGR02966 92 YGEE--QKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQSQRMQSLVE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 415 EIIQLSKDEETAH--ETQTIHLATYFEQIIQSYQPMIEKKHLTLEMQQKEQSFTTQTEL-LYPIIKNLIENAIQYSKESE 491
Cdd:TIGR02966 170 DLLTLSRLESAASplEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDeLRSAFSNLVSNAIKYTPEGG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 492 KIIIR-YEVDNQLTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTF 570
Cdd:TIGR02966 250 TITVRwRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESELGKGSTF 329
|
....
gi 1672584895 571 TVTI 574
Cdd:TIGR02966 330 SFIF 333
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
349-577 |
5.69e-67 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 217.47 E-value: 5.69e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 349 LTKVRRLEKLQKDFVGNVSHELKTPVTSLIGFTETLLDGAKDDPKILNEFLLIMQKDAIRLDKLIREIIQLSKDEETAH- 427
Cdd:COG2205 6 LEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLs 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 428 -ETQTIHLATYFEQIIQSYQPMIEKKHLTLEMQQKEQSFTTQT--ELLYPIIKNLIENAIQYSKESEKIIIR-YEVDNQL 503
Cdd:COG2205 86 lELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYAdpELLEQVLANLLDNAIKYSPPGGTITISaRREGDGV 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1672584895 504 TFSVQDFGIGIDREDQERIFERFYRVDkaRSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIPPA 577
Cdd:COG2205 166 RISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLA 237
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
251-575 |
6.59e-67 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 220.55 E-value: 6.59e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 251 LLNELMIGVFLIDSESHLRLLNPKMQAHLGVHDYQPNQRYTEIIQEPKLIQLIHQVTPNEPLIHQEITISEGQQTLDISL 330
Cdd:COG0642 2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 331 RYFNSSEETGQILGVAYDLTKVRRLEKLQKDFVGNVSHELKTPVTSLIGFTETLLDGAKDDpkiLNEFLLIMQKDAIRLD 410
Cdd:COG0642 82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEE---QREYLETILRSADRLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 411 KLIREIIQLSKDE--ETAHETQTIHLATYFEQIIQSYQPMIEKKHLTLEMQQKEQSFTTQT--ELLYPIIKNLIENAIQY 486
Cdd:COG0642 159 RLINDLLDLSRLEagKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGdpDRLRQVLLNLLSNAIKY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 487 SKESEKIIIRYEVDN-QLTFSVQDFGIGIDREDQERIFERFYRVDkaRSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPG 565
Cdd:COG0642 239 TPEGGTVTVSVRREGdRVRISVEDTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVESEPG 316
|
330
....*....|
gi 1672584895 566 MGSTFTVTIP 575
Cdd:COG0642 317 KGTTFTVTLP 326
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
276-576 |
2.26e-45 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 165.95 E-value: 2.26e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 276 QAHLGVHDYQPN-QRYTEIIQEPKLIQLIHQVTPNEPLihqEITISEGQQtldISLRYFNSSEetGQILGVAYDLTKVRR 354
Cdd:PRK11006 128 QQLLGFRWPEDNgQNILNLLRYPEFTQYLKTRDFSRPL---TLVLNNGRH---LEIRVMPYTE--GQLLMVARDVTQMHQ 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 355 LEKLQKDFVGNVSHELKTPVTSLIGFTETLLDGAKDDPkILNEFLLIMQKDAIRLDKLIREIIQLSKDEETAhetqTIHL 434
Cdd:PRK11006 200 LEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGA-LREKALHTMREQTQRMEGLVKQLLTLSKIEAAP----TIDL 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 435 atyfEQIIQSyqPM----IEKKHLTLEMQQKEQSFTTQTEL--------LYPIIKNLIENAIQYSKESEKIIIR-YEVDN 501
Cdd:PRK11006 275 ----NEKVDV--PMmlrvLEREAQTLSQGKHTITFEVDNSLkvfgnedqLRSAISNLVYNAVNHTPEGTHITVRwQRVPQ 348
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1672584895 502 QLTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIPP 576
Cdd:PRK11006 349 GAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPE 423
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
181-577 |
2.90e-44 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 162.44 E-value: 2.90e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 181 MSYYLVYQRNRPLKTVLPVLKKmVKNPDKTETIMQTS-DQWEELYQMINALSEQMSKVYRAYTTTEEQLYTLLNELMIGV 259
Cdd:COG5000 25 LALLLARRLTRPLRRLAEATRA-VAAGDLSVRLPVTGdDEIGELARAFNRMTDQLKEQREELEERRRYLETILENLPAGV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 260 FLIDSESHLRLLNPKMQAHLGV-HDYQPNQRYTEIIQEPKLIQLIHQVTpnEPLIHQEITIS-EGQQTLDISLRYFnssE 337
Cdd:COG5000 104 IVLDADGRITLANPAAERLLGIpLEELIGKPLEELLPELDLAELLREAL--ERGWQEEIELTrDGRRTLLVRASPL---R 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 338 ETGQILgVAYDLTKVRRLEKLQ--KDFVGNVSHELKTPVTSLIGFTETL----LDGAKDDPKILNEFLLIMQKDAIRLDK 411
Cdd:COG5000 179 DDGYVI-VFDDITELLRAERLAawGELARRIAHEIKNPLTPIQLSAERLrrklADKLEEDREDLERALDTIIRQVDRLKR 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 412 LIREIIQLSKDEETahETQTIHLATYFEQIIQSYQPMIEKKHLTLEMQQKEQSFTTQ--TELLYPIIKNLIENAIQYSKE 489
Cdd:COG5000 258 IVDEFLDFARLPEP--QLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLadRDQLEQVLINLLKNAIEAIEE 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 490 SEKIIIR-YEVDNQLTFSVQDFGIGIDREDQERIFERFYrvdkarSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGS 568
Cdd:COG5000 336 GGEIEVStRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGT 409
|
....*....
gi 1672584895 569 TFTVTIPPA 577
Cdd:COG5000 410 TFTIRLPLA 418
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
244-575 |
8.68e-42 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 154.23 E-value: 8.68e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 244 TEEQLYTLLNELMIGVFLIDSESHLRLLNPKMQAHLGVHDYQ-PNQRYTEIIQEP-KLIQLIHQV-TPNEPLIHQEITIS 320
Cdd:COG3852 5 SEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEElLGRPLAELFPEDsPLRELLERAlAEGQPVTEREVTLR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 321 --EGQQ-TLDISLRYFNSSEETGQILGVAYDLTKVRRLE-------KLQ--KDFVGNVSHELKTPVTSLIGFTETLLDGA 388
Cdd:COG3852 85 rkDGEErPVDVSVSPLRDAEGEGGVLLVLRDITERKRLErelrraeKLAavGELAAGLAHEIRNPLTGIRGAAQLLEREL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 389 KDDPkiLNEFLLIMQKDAIRLDKLIREIIQLSKDEETAHETQTIHlatyfeQIIQSYQPMIE---KKHLTLE-------- 457
Cdd:COG3852 165 PDDE--LREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLH------EVLERVLELLRaeaPKNIRIVrdydpslp 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 458 --------MQQkeqsfttqtellypIIKNLIENAIQYSKESEKIIIRYEVDNQLT-----------FSVQDFGIGIDRED 518
Cdd:COG3852 237 evlgdpdqLIQ--------------VLLNLVRNAAEAMPEGGTITIRTRVERQVTlgglrprlyvrIEVIDNGPGIPEEI 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1672584895 519 QERIFERFYrvdkarSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:COG3852 303 LDRIFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
72-577 |
1.02e-38 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 148.78 E-value: 1.02e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 72 VHQSNERLTLLAPNGTILFDTTDHSLRGQRNTRPEIKAVLDGGSLGTSLRMSSTLKEELLYVALPIKKNGQLEAIIRIAE 151
Cdd:COG4251 4 LALLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 152 PTNGFLPRTENFRRWVFFFFLVFFVVLSSMSYYLVYQRNRPLKTVLPVLKKMVKNPDKTETIMQTSDQWEELyQMINALS 231
Cdd:COG4251 84 LLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLL-LLLLLLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 232 EQMSKVYRAYTTTEEQLYTLLNELMIGVFLIDSESHLRLLNPKMQAHLGVHDYQPNQRYTEIIQEPKLIQLIHQVTPNEP 311
Cdd:COG4251 163 LLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 312 LIHQEITISEGQQTLDISLRYFNSSEETgqilgvaydltKVRRLEKLQKD---FVGNVSHELKTPVTSLIGFTETLLD-- 386
Cdd:COG4251 243 LLLLLLILVLELLELRLELEELEEELEE-----------RTAELERSNEEleqFAYVASHDLREPLRKISGFSQLLEEdy 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 387 GAKDDPKILnEFLLIMQKDAIRLDKLIREIIQLSKDEETAHETQTIHLATYFEQIIQSYQPMIEKKHLTLEMQqKEQSFT 466
Cdd:COG4251 312 GDKLDEEGR-EYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVG-PLPTVR 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 467 TQTELLYPIIKNLIENAIQYSKESE--KIIIRYEV-DNQLTFSVQDFGIGIDREDQERIFERFYRVDkaRSRHSGGTGLG 543
Cdd:COG4251 390 GDPTLLRQVFQNLISNAIKYSRPGEppRIEIGAEReGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIG 467
|
490 500 510
....*....|....*....|....*....|....
gi 1672584895 544 LAIVKDYVNLLGGTIKVESHPGMGSTFTVTIPPA 577
Cdd:COG4251 468 LAIVKKIVERHGGRIWVESEPGEGATFYFTLPKA 501
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
213-575 |
5.01e-36 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 140.88 E-value: 5.01e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 213 IMQTSDQWEELYQMINALSEQ--MSKVYRaytTTEEQLYTLLNELMIGVFLIDSESHLRLLNPKMQAHLGVHDYQP-NQR 289
Cdd:COG5809 109 IFDQNGDIEGMLAISRDITERkrMEEALR---ESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELiGKS 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 290 YTEIIQEP---KLIQLIHQVTPNEPLIHQEITI--SEGQqTLDISLRYF--NSSEETGQILGVAYDLT-------KVRRL 355
Cdd:COG5809 186 ILELIHSDdqeNVAAFISQLLKDGGIAQGEVRFwtKDGR-WRLLEASGApiKKNGEVDGIVIIFRDITerkkleeLLRKS 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 356 EKLQK--DFVGNVSHELKTPVTSLIGFTETLLDGAKDDPKilnEFLLIMQKDAIRLDKLIREIIQLSKDEETahETQTIH 433
Cdd:COG5809 265 EKLSVvgELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQK---TYLDIMLSELDRIESIISEFLVLAKPQAI--KYEPKD 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 434 LATYFEQIIQSYQP--MIEKKHLTLEMQQKEQSFTTQTELLYPIIKNLIENAIQYSKESEKIIIR--YEVDNQLTFSVQD 509
Cdd:COG5809 340 LNTLIEEVIPLLQPqaLLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIEtkAEDDDKVVISVTD 419
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1672584895 510 FGIGIDREDQERIFERFYrvdkarSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:COG5809 420 EGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
470-577 |
5.17e-36 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 130.46 E-value: 5.17e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 470 ELLYPIIKNLIENAIQYSKESEKIIIRYE-VDNQLTFSVQDFGIGIDREDQERIFERFYRVDKaRSRHSGGTGLGLAIVK 548
Cdd:smart00387 4 DRLRQVLSNLLDNAIKYTPEGGRITVTLErDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSIVK 82
|
90 100
....*....|....*....|....*....
gi 1672584895 549 DYVNLLGGTIKVESHPGMGSTFTVTIPPA 577
Cdd:smart00387 83 KLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
472-574 |
3.15e-35 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 127.72 E-value: 3.15e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 472 LYPIIKNLIENAIQYSKESEKIIIR-YEVDNQLTFSVQDFGIGIDREDQERIFERFYRVDKarSRHSGGTGLGLAIVKDY 550
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISlRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 1672584895 551 VNLLGGTIKVESHPGMGSTFTVTI 574
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
475-575 |
1.20e-33 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 123.76 E-value: 1.20e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 475 IIKNLIENAIQYSKESEkIIIRYEVD------NQLTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVK 548
Cdd:cd16922 4 ILLNLLGNAIKFTEEGE-VTLRVSLEeeeedgVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISK 82
|
90 100
....*....|....*....|....*..
gi 1672584895 549 DYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16922 83 KLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
470-577 |
1.30e-32 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 120.94 E-value: 1.30e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 470 ELLYPIIKNLIENAIQYSKESEKIIIRYEVDNQLTFSVQDFGIGIDREDQERIFERFYRVDKarsRHSGGTGLGLAIVKD 549
Cdd:pfam02518 4 LRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSIVRK 80
|
90 100
....*....|....*....|....*...
gi 1672584895 550 YVNLLGGTIKVESHPGMGSTFTVTIPPA 577
Cdd:pfam02518 81 LVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
292-575 |
4.80e-32 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 126.84 E-value: 4.80e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 292 EIIQEPKLIQLIHQVTPNEPLIHQEITISEGQQTLDISLRYFNSSEETGQILGVAYDLTKVRR----LEKLQKDFV---- 363
Cdd:COG4191 59 LLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERaeeeLRELQEQLVqsek 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 364 --------GNVSHELKTPVTSLIGFTETLLDGAKD--DPKILNEFLLIMQKDAIRLDKLIREIIQLSKDEEtaHETQTIH 433
Cdd:COG4191 139 laalgelaAGIAHEINNPLAAILGNAELLRRRLEDepDPEELREALERILEGAERAAEIVRSLRAFSRRDE--EEREPVD 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 434 LATYFEQIIQSYQPMIEKKHLTLEMQQKEQSFTTqteLLYP-----IIKNLIENAIQYSKESE--KIIIR-YEVDNQLTF 505
Cdd:COG4191 217 LNELIDEALELLRPRLKARGIEVELDLPPDLPPV---LGDPgqleqVLLNLLINAIDAMEEGEggRITIStRREGDYVVI 293
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1672584895 506 SVQDFGIGIDREDQERIFERFY---RVDKarsrhsgGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:COG4191 294 SVRDNGPGIPPEVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
472-577 |
4.40e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 113.84 E-value: 4.40e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 472 LYPIIKNLIENAIQYSKESEKIIIRYEVDNQ-LTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVKDY 550
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESgARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*..
gi 1672584895 551 VNLLGGTIKVESHPGMGSTFTVTIPPA 577
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFPSS 107
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
342-575 |
2.40e-29 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 123.51 E-value: 2.40e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 342 ILGVAYDLTKVRR----LEKLQKD---FVGNVSHELKTPVTSLIGFTETLLDGAKDDPK----------------ILNef 398
Cdd:PRK11091 259 LMGFGRDITERKRyqdaLEKASRDkttFISTISHELRTPLNGIVGLSRILLDTELTAEQrkylktihvsaitlgnIFN-- 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 399 llimqkDAIRLDKLIREIIQLSkdeetaheTQTIHLATYFEQIIQSYQPMIEKKHLTLEMQQKE---QSFTTQTELLYPI 475
Cdd:PRK11091 337 ------DIIDMDKMERRKLQLD--------NQPIDFTDFLADLENLSGLQAEQKGLRFDLEPLLplpHKVITDGTRLRQI 402
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 476 IKNLIENAIQYSKESEKII-IRYEVDNQLTFSVQDFGIGIDREDQERIFERFYRV-DKARSRHSGGTGLGLAIVKDYVNL 553
Cdd:PRK11091 403 LWNLISNAVKFTQQGGVTVrVRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQA 482
|
250 260
....*....|....*....|..
gi 1672584895 554 LGGTIKVESHPGMGSTFTVTIP 575
Cdd:PRK11091 483 MGGDITVTSEEGKGSCFTLTIH 504
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
354-575 |
2.67e-29 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 120.96 E-value: 2.67e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 354 RLE----KLQkDFVGNVSHELKTPVTSLIGFTETLLDGAKDDPKiLNEFLLIMQKDAIRLDKLIREIIQLSKDEE--TAH 427
Cdd:TIGR01386 233 RLEdafqRLS-QFSADLAHELRTPLTNLLGQTQVALSQPRTGEE-YREVLESNLEELERLSRMVSDMLFLARADNgqLAL 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 428 ETQTIHLATYFEQIIQSYQPMIEKKHLTLEMQqKEQSFTTQTELLYPIIKNLIENAIQYSKESEKIIIRYEVD-NQLTFS 506
Cdd:TIGR01386 311 ERVRLDLAAELAKVAEYFEPLAEERGVRIRVE-GEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRsDEVRVS 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1672584895 507 VQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMgSTFTVTIP 575
Cdd:TIGR01386 390 VSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
252-575 |
3.11e-28 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 119.30 E-value: 3.11e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 252 LNELMI-----GVFLIDSESHLRLLNPKMQAHLGV--HD--YQPnqrYTEI------IQEPKLIQLIHqvtpNEPLIHQE 316
Cdd:PRK11360 263 LNELILesiadGVIAIDRQGKITTMNPAAEVITGLqrHElvGKP---YSELfppntpFASPLLDTLEH----GTEHVDLE 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 317 ITISEGQQTLDISL---RYFNSseeTGQILGVAY---DLT-------KVRRLEKLQK--DFVGNVSHELKTPVTSLIGFT 381
Cdd:PRK11360 336 ISFPGRDRTIELSVstsLLHNT---HGEMIGALVifsDLTerkrlqrRVARQERLAAlgELVAGVAHEIRNPLTAIRGYV 412
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 382 ETLLDGAKDDPKilNEFLLIMQKDAIRLDKLIREIIQLSKDEEtaHETQTIHLATYFEQIIQSYQPMIEKKHLTLEMQQk 461
Cdd:PRK11360 413 QIWRQQTSDPPS--QEYLSVVLREVDRLNKVIDQLLEFSRPRE--SQWQPVSLNALVEEVLQLFQTAGVQARVDFETEL- 487
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 462 EQSFTT---QTELLYPIIKNLIENAIQYSKESEKIIIR--YEVDNQLTFSVQDFGIGIDREDQERIFERFYRVdKARsrh 536
Cdd:PRK11360 488 DNELPPiwaDPELLKQVLLNILINAVQAISARGKIRIRtwQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTT-KAK--- 563
|
330 340 350
....*....|....*....|....*....|....*....
gi 1672584895 537 sgGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:PRK11360 564 --GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
334-575 |
8.89e-28 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 116.66 E-value: 8.89e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 334 NSSEETGQIlgvAYDLTKV-RRLEK---LQKDFVGNVSHELKTPVTSLIGFTETLLDGA-KDDPKILNEflliMQKDAIR 408
Cdd:PRK10549 214 TSRDELGRL---AQDFNQLaSTLEKneqMRRDFMADISHELRTPLAVLRGELEAIQDGVrKFTPESVAS----LQAEVGT 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 409 LDKLIREIIQLSKDEE--TAHETQTIHLATYFEQIIQSYQPMIEKKHLTLEMQQKEQ-SFTTQTELLYPIIKNLIENAIQ 485
Cdd:PRK10549 287 LTKLVDDLHQLSLSDEgaLAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSaTVFGDPDRLMQLFNNLLENSLR 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 486 YSKESEKIIIRYEV-DNQLTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVKDYVNLLGGTIKVESHP 564
Cdd:PRK10549 367 YTDSGGSLHISAEQrDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSP 446
|
250
....*....|.
gi 1672584895 565 GMGSTFTVTIP 575
Cdd:PRK10549 447 FGGVSITVELP 457
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
362-575 |
1.32e-27 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 118.15 E-value: 1.32e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 362 FVGNVSHELKTPVTSLIGFTETLldGAKDDPKILNEFLLIMQKDAIRLDKLIREIIQLSKDEE----------TAHETQT 431
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDLL--QTKELPKGVDRLVTAMNNSSSLLLKIISDILDFSKIESeqlkieprefSPREVIN 527
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 432 ihlatyfeQIIQSYQPMIEKKHLTL-----------------EMQQkeqsfttqtellypIIKNLIENAIQYSkESEKII 494
Cdd:PRK10841 528 --------HITANYLPLVVKKRLGLycfiepdvpvalngdpmRLQQ--------------VISNLLSNAIKFT-DTGCIV 584
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 495 IRYEVDNQ-LTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVT 573
Cdd:PRK10841 585 LHVRVDGDyLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIR 664
|
..
gi 1672584895 574 IP 575
Cdd:PRK10841 665 IP 666
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
472-575 |
9.10e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 104.33 E-value: 9.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 472 LYPIIKNLIENAIQYSKESEKIIIRYEvDNQLTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVKDYV 551
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQD-GDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAI 79
|
90 100
....*....|....*....|....
gi 1672584895 552 NLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16949 80 EQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
343-575 |
1.25e-26 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 113.40 E-value: 1.25e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 343 LGVAYDlTKVRRLEKLQ--KDFVGNVSHELKTPVTSLIGFTEtLLDGAKDdPKILNEFLLIMQKDAIRLDKLIREIIQLS 420
Cdd:PRK11100 239 LAQALE-SMRVKLEGKAyvEQYVQTLTHELKSPLAAIRGAAE-LLQEDPP-PEDRARFTGNILTQSARLQQLIDRLLELA 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 421 KDEE--TAHETQTIHLATYFEQIIQSYQPMIEKKHLTLEMQQKEQSFTTQTELLYPIIKNLIENAIQYSKESEKIIIRYE 498
Cdd:PRK11100 316 RLEQrqELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAE 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 499 VDN-QLTFSVQDFGIGIDREDQERIFERFY---RVDKARSrhsgGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTI 574
Cdd:PRK11100 396 VDGeQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
|
.
gi 1672584895 575 P 575
Cdd:PRK11100 472 P 472
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
359-575 |
4.49e-26 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 111.56 E-value: 4.49e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 359 QKDFVGNVSHELKTPVTSLIGFTETLLDGAKDDP---KILNEfllimqkdAIRLDKLIREIIQLSKDEETAH---ETQTI 432
Cdd:PRK09470 243 QQRLLSDISHELRTPLTRLQLATALLRRRQGESKeleRIETE--------AQRLDSMINDLLVLSRNQQKNHlerETFKA 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 433 HlaTYFEQIIQSYQPMIE--KKHLTLEMQQKEQSFTTQTELLYPIIKNLIENAIQYSKEseKIIIRYEVDNQ-LTFSVQD 509
Cdd:PRK09470 315 N--SLWSEVLEDAKFEAEqmGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDgLTITVDD 390
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1672584895 510 FGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:PRK09470 391 DGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
359-575 |
3.05e-25 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 109.09 E-value: 3.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 359 QKDFVGNVSHELKTPVTSLIGFTETLLDGAKDdPKILNEFLLIMQKDAIRLDKLIREIIQLSK-DEETAH-ETQTIHLAT 436
Cdd:PRK09835 262 QSNFSADIAHEIRTPITNLITQTEIALSQSRS-QKELEDVLYSNLEELTRMAKMVSDMLFLAQaDNNQLIpEKKMLDLAD 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 437 YFEQIIQSYQPMIEKKHLTLEMQQKEQSFTTQTELLYPIIKNLIENAIQYSKESEKIIIRY-EVDNQLTFSVQDFGIGID 515
Cdd:PRK09835 341 EVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCqEVDHQVQLVVENPGTPIA 420
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 516 REDQERIFERFYRVDKARSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPgMGSTFTVTIP 575
Cdd:PRK09835 421 PEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
360-575 |
1.21e-24 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 106.61 E-value: 1.21e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 360 KDFVGNVSHELKTPVTSLIGFTETLLDGAKDDPKILNefllimqKDAIRLDKLIREII---QLSKDEETAHeTQTIHLAT 436
Cdd:PRK10604 213 KQLIDGIAHELRTPLVRLRYRLEMSDNLSAAESQALN-------RDIGQLEALIEELLtyaRLDRPQNELH-LSEPDLPA 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 437 YFEQIIQSYQPMIEKKHLTLEMQQKEQSFTTQTELLYPIIKNLIENAIQYSKESEKIIIRYEvDNQLTFSVQDFGIGIDR 516
Cdd:PRK10604 285 WLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLD-GNQACLIVEDDGPGIPP 363
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1672584895 517 EDQERIFERFYRVDKARSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:PRK10604 364 EERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
475-575 |
1.60e-23 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 95.64 E-value: 1.60e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 475 IIKNLIENAIQYSKESEKIIIRYEVD--NQLTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVKDYVN 552
Cdd:cd16925 8 VVLNLLSNAFKFTPDGGRIRCILEKFrlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKEFVE 87
|
90 100
....*....|....*....|...
gi 1672584895 553 LLGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16925 88 LHGGTVTVSDAPGGGALFQVELP 110
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
244-575 |
2.88e-23 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 103.27 E-value: 2.88e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 244 TEEQLYTLLNELMIGVFLIDSESHLRLLNPKMQAHLGVHDYqpnqrytEIIQEpKLIQLIHQVTPNEpLIHQEITISEGQ 323
Cdd:COG5805 155 QEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPRE-------ELIGK-NLLELLHPCDKEE-FKERIESITEVW 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 324 Q---------TLDISLRYFNSS---------EETGqILGVAYDLTK-------VRRLEKLQkdFVGN----VSHELKTPV 374
Cdd:COG5805 226 QefiiereiiTKDGRIRYFEAVivplidtdgSVKG-ILVILRDITEkkeaeelMARSEKLS--IAGQlaagIAHEIRNPL 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 375 TSLIGFTeTLLDGAKDDPKilnEFLLIMQKDAIRLDKLIREIIQLSKDEETAHETQTIHlatyfeQIIQSYQPMIEKKHL 454
Cdd:COG5805 303 TSIKGFL-QLLQPGIEDKE---EYFDIMLSELDRIESIISEFLALAKPQAVNKEKENIN------ELIQDVVTLLETEAI 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 455 tleMQQKEQSFTTQTELLY---------PIIKNLIENAIQYSKESEKIIIR-YEVDNQLTFSVQDFGIGIDREDQERIFE 524
Cdd:COG5805 373 ---LHNIQIRLELLDEDPFiycdenqikQVFINLIKNAIEAMPNGGTITIHtEEEDNSVIIRVIDEGIGIPEERLKKLGE 449
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1672584895 525 RFYrvdkarSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:COG5805 450 PFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
472-575 |
4.50e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 94.07 E-value: 4.50e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 472 LYPIIKNLIENAIQYSKESEKIIIRY-EVDNQLTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVKDY 550
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAaQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHNI 84
|
90 100
....*....|....*....|....*
gi 1672584895 551 VNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
345-575 |
2.42e-22 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 101.85 E-value: 2.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 345 VAYDLTKVRRLE--KLQKDFVGNVSHELKTPVTSLIGFTETLLdgaKDDpkiLNE----FLLIMQKDAIRLDKLIREIIQ 418
Cdd:PRK11107 277 VELDLAKKRAQEaaRIKSEFLANMSHELRTPLNGVIGFTRQTL---KTP---LTPtqrdYLQTIERSANNLLAIINDILD 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 419 LSKDE--------------ETAHETQTIhLATyfeqiiqSYQpmiEKK-HLTLEMQQK-EQSFTTQTELLYPIIKNLIEN 482
Cdd:PRK11107 351 FSKLEagklvlenipfslrETLDEVVTL-LAH-------SAH---EKGlELTLNIDPDvPDNVIGDPLRLQQIITNLVGN 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 483 AIQYSkESEKIIIRYEV----DNQLT--FSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVKDYVNLLGG 556
Cdd:PRK11107 420 AIKFT-ESGNIDILVELralsNTKVQleVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGG 498
|
250
....*....|....*....
gi 1672584895 557 TIKVESHPGMGSTFTVTIP 575
Cdd:PRK11107 499 DISFHSQPNRGSTFWFHLP 517
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
365-575 |
1.25e-21 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 99.33 E-value: 1.25e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 365 NVSHELKTPVTSLIGFTEtLLDGAKDDPKILnEFLLIMQKDAIRLDKLIREIIQLSKDEEtahETQTIHLATY-----FE 439
Cdd:PRK15347 404 TISHEIRTPLNGVLGALE-LLQNTPLTAEQM-DLADTARQCTLSLLAIINNLLDFSRIES---GQMTLSLEETallplLD 478
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 440 QIIQSYQPMIEKKHLTLEM---QQKEQSFTTQTELLYPIIKNLIENAIQYSkESEKIIIRYEV-DNQLTFSVQDFGIGID 515
Cdd:PRK15347 479 QAMLTIQGPAQSKSLTLRTfvgAHVPLYLHLDSLRLRQILVNLLGNAVKFT-ETGGIRLRVKRhEQQLCFTVEDTGCGID 557
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 516 REDQERIFERFYRVDKarsrHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:PRK15347 558 IQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-575 |
1.48e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 89.69 E-value: 1.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 475 IIKNLIENAIQYSKESE--KIIIRY-EVDNQLTFSVQDFGIGIDREDQERIFERFYRVDkarSRH-SGGTGLGLAIVKDY 550
Cdd:cd16921 4 VLTNLLGNAIKFRRPRRppRIEVGAeDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SREeYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 1672584895 551 VNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
469-574 |
6.92e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 88.34 E-value: 6.92e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 469 TELLYPIIKNLIENAIQYSKESEKI-IIRYEVDNQLTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIV 547
Cdd:cd16947 18 TEALQRILKNLISNAIKYGSDGKFLgMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTIT 97
|
90 100
....*....|....*....|....*..
gi 1672584895 548 KDYVNLLGGTIKVESHPGMGSTFTVTI 574
Cdd:cd16947 98 KRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
223-575 |
8.19e-21 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 94.53 E-value: 8.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 223 LYQMINALSEQMSKVYRAYTTTEEQLYTLLNELMIGVFLIDSESHLRLLNPKMQAHLGVHdyqpnqryteiiQEPKLIQL 302
Cdd:COG3290 61 LLLLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLD------------AIGRPIDE 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 303 IHQVTPNEPLIHQEITIseGQQTLDISLRYFNSSEETGQILGVAYDLTKVRRLEK---LQKDFVGNV---SHELKTPVTS 376
Cdd:COG3290 129 VLAEVLETGERDEEILL--NGRVLVVNRVPIRDDGRVVGAVATFRDRTELERLEEeleGVKELAEALraqRHDFRNHLHT 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 377 LIGFTETLldgakddpkilnefllimqkdaiRLDKLIREIIQLSKDEETAHETQTIHLA-TYFEQIIQSYQPMIEKKHLT 455
Cdd:COG3290 207 ISGLLQLG-----------------------EYDEALEYIDEISEELQELIDSLLSRIGnPVLAALLLGKAARARERGID 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 456 LEMQQKEQ--SFTTQTELLYPIIKNLIENAI---QYSKESEKII---IRYEvDNQLTFSVQDFGIGIDREDQERIFERFY 527
Cdd:COG3290 264 LTIDIDSDlpDLPLSDTDLVTILGNLLDNAIeavEKLPEEERRVelsIRDD-GDELVIEVEDSGPGIPEELLEKIFERGF 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1672584895 528 RvdkarSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:COG3290 343 S-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
472-575 |
1.01e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 87.34 E-value: 1.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 472 LYPIIKNLIENAIQYSKESEKIIIR-YEVDNQLTFSVQDFGIGIDREDQERIFERFYRVDKARsRHSGGTGLGLAIVKDY 550
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYsETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKKL 84
|
90 100
....*....|....*....|....*
gi 1672584895 551 VNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16948 85 CDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
470-575 |
1.54e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 86.71 E-value: 1.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 470 ELLYPIIKNLIENAIQYSKESEKIIIR-YEVDNQLTFSVQDFGIGIDREDQERIFERFYRVDKARSrhsgGTGLGLAIVK 548
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAMEGRGRITIRtWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSY 77
|
90 100
....*....|....*....|....*..
gi 1672584895 549 DYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16943 78 RIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
468-567 |
1.99e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 86.69 E-value: 1.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 468 QTELLYPIIKNLIENAIQYSKESEKIIIRYEVDNQLTFSVQDFGIGIDREDQERIFERFYRVDKarsRHSGGTGLGLAIV 547
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSIV 86
|
90 100
....*....|....*....|
gi 1672584895 548 KDYVNLLGGTIKVESHPGMG 567
Cdd:cd16940 87 KRIVELHGGQIFLGNAQGGG 106
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
359-575 |
4.68e-20 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 94.80 E-value: 4.68e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 359 QKDFVGNVSHELKTPVTSLIGFTEtLLDGAKDDPKILNEFLLIMQKDAIRLDKLIREIIQLSKDEETAHETQT--IHLAT 436
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLE-LLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPqwVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 437 YFEQIIQSYQPMIEKKHLTLEMQQK---EQSFTTQTELLYPIIKNLIENAIQYSKESEKIIIRYEV---DNQ--LTFSVQ 508
Cdd:PRK09959 791 LVQNTCHSFGAIAASKSIALSCSSTfpdHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLGhidDNHavIKMTIM 870
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1672584895 509 DFGIGIDREDQERIFERFYRVDKARSRhsGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:PRK09959 871 DSGSGLSQEEQQQLFKRYSQTSAGRQQ--TGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
472-575 |
4.94e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 85.13 E-value: 4.94e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 472 LYPIIKNLIENAIQYSKESEKI-IIRYEVDNQLTFSVQDFGIGIDREDQERIFERFYRVDKarSRHSGGTGLGLAIVKDY 550
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIyITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 1672584895 551 VNLLGGTIKVESHpGMGSTFTVTIP 575
Cdd:cd16923 79 IELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
356-575 |
7.78e-20 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 93.95 E-value: 7.78e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 356 EKLQKDFVGNVSHELKTPVTSLIGFTETL-LDGAKDDPK-----------ILNEF-----LLIM---QKDAIRLDKlire 415
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEILtLDLASEGSPharqaseirqqVLNTTrlvnnLLDMariQSGGFNLRK---- 736
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 416 iiqlskdeetahETQTIhlatyfEQII----QSYQPMIEKKHLTLEMQQKEQSFTTQTELLYPIIKNLIENAIQYSKESE 491
Cdd:PRK10490 737 ------------EWLTL------EEVVgsalQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQA 798
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 492 KIIIRYEV-DNQLTFSVQDFGIGIDREDQERIFERFYRVDKARSrhSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTF 570
Cdd:PRK10490 799 EIGIDAHVeGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACF 876
|
....*
gi 1672584895 571 TVTIP 575
Cdd:PRK10490 877 RVTLP 881
|
|
| sCache_like |
pfam16736 |
Single Cache-like; This entry represents the N-terminal Cache-like domain of the alkaline ... |
35-151 |
1.51e-19 |
|
Single Cache-like; This entry represents the N-terminal Cache-like domain of the alkaline phosphatase synthesis sensor protein PhoR. It covers part of the PAS-like fold that share a central five-stranded beta- sheet of identical topology to other PAS domains.
Pssm-ID: 407005 Cd Length: 114 Bit Score: 84.36 E-value: 1.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 35 IIEQQESYLSKKGQLLIQQLTIDDLSSKHNQSVLTDFVHQSNERLTLLAPNGTILFDTTDHslRGQRNTRPEIKAVLDGG 114
Cdd:pfam16736 1 YVEKLEERMEKEAKLLASLLENENLDAAQNKTVLEEASEKLDARITIIDADGKVLYDTGGE--TEDAEHEAIIQELLSGE 78
|
90 100 110
....*....|....*....|....*....|....*..
gi 1672584895 115 SLGTsLRMSSTLKEELLYVALPIKKNGQLEAIIRIAE 151
Cdd:pfam16736 79 ELQE-VRVITTDEDDLLYYAVPIQKEGEQEGYILLSS 114
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
366-575 |
8.21e-19 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 88.47 E-value: 8.21e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 366 VSHELKTPVTSLIGFTETLLDGAKDDPKILNEFLLIMQKDAIR-----LDKLIREIIQLSK--DEETAHETQTIHLATYF 438
Cdd:PRK09303 158 LAHDLRTPLTAASLALETLELGQIDEDTELKPALIEQLQDQARrqleeIERLITDLLEVGRtrWEALRFNPQKLDLGSLC 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 439 EQIIQSYQPMIEKKHLTLEM---QQKEQSFTTQtELLYPIIKNLIENAIQYSKESEKI--IIRYEVDNQLTFSVQDFGIG 513
Cdd:PRK09303 238 QEVILELEKRWLAKSLEIQTdipSDLPSVYADQ-ERIRQVLLNLLDNAIKYTPEGGTItlSMLHRTTQKVQVSICDTGPG 316
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1672584895 514 IDREDQERIFERFYRVDkaRSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:PRK09303 317 IPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
352-575 |
1.21e-18 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 88.69 E-value: 1.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 352 VRRLEKLQKdfVGN----VSHELKTPVTSLIG----FTETLLDGAKDdpkilNEFLLIMQKDAIRLDKLIREIIQLSKDE 423
Cdd:PRK10364 228 MKRKEKLVA--LGHlaagVAHEIRNPLSSIKGlakyFAERAPAGGEA-----HQLAQVMAKEADRLNRVVSELLELVKPT 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 424 ETAheTQTIHLATYFEQIIQSYQPMIEKKHLTLEMQQKEQSFTTQT--ELLYPIIKNLIENAIQYSKESEKIIIR-YEVD 500
Cdd:PRK10364 301 HLA--LQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQAdpDRLTQVLLNLYLNAIQAIGQHGVISVTaSESG 378
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1672584895 501 NQLTFSVQDFGIGIDREDQERIFERFYrVDKARsrhsgGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:PRK10364 379 AGVKISVTDSGKGIAADQLEAIFTPYF-TTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
476-575 |
1.28e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 81.32 E-value: 1.28e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 476 IKNLIENAIQYSKESEKIIIRYEvDNQLTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVKDYVNLLG 555
Cdd:cd16939 5 LDNLLRNALRYAHRTVRIALLVS-GGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALWHG 83
|
90 100
....*....|....*....|
gi 1672584895 556 GTIKVESHPGMGSTFTVTIP 575
Cdd:cd16939 84 GHVECDDSELGGACFRLTWP 103
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-575 |
2.80e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 80.41 E-value: 2.80e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 475 IIKNLIENAI---QYSKESEKII---IRYEVDnQLTFSVQDFGIGIDREDQERIFERFYRvdkarSRHSGGTGLGLAIVK 548
Cdd:cd16915 4 IVGNLIDNALdalAATGAPNKQVevfLRDEGD-DLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVR 77
|
90 100
....*....|....*....|....*..
gi 1672584895 549 DYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16915 78 QSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
468-575 |
3.53e-16 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 81.50 E-value: 3.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 468 QTELLYPIIKNLIENAIQYSKESEK----IIIRYEvDNQLTFSVQDFGIGIDREDQERIFERFYrvdkarSRHSGGTGLG 543
Cdd:PRK11086 430 QVHELITILGNLIENALEAVGGEEGgeisVSLHYR-NGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVG 502
|
90 100 110
....*....|....*....|....*....|..
gi 1672584895 544 LAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:PRK11086 503 LYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-575 |
1.13e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 72.87 E-value: 1.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 475 IIKNLIENAIQYSKESekIIIRYEVD-NQLTFSVQDFGIGIDREDQERIFERFYRVDKARSrhSGGTGLGLAIVKDYVNL 553
Cdd:cd16950 4 VLSNLVDNALRYGGGW--VEVSSDGEgNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISDA 79
|
90 100
....*....|....*....|..
gi 1672584895 554 LGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16950 80 HGGSLTLANRAGGGLCARIELP 101
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
366-564 |
2.74e-15 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 78.41 E-value: 2.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 366 VSHELKTPVTSLIGFTET-------LLDGAKDDPK----ILNEFLLI------MQKDAIRLDKLIREIIQlskdEETAHE 428
Cdd:PRK09467 236 VSHDLRTPLTRIRLATEMmseedgyLAESINKDIEecnaIIEQFIDYlrtgqeMPMEMADLNALLGEVIA----AESGYE 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 429 TQtIHLATYFEQIIQSYQPMIEKKhltlemqqkeqsfttqtellypIIKNLIENAIQYSKESEKIIIRYEvDNQLTFSVQ 508
Cdd:PRK09467 312 RE-IETALQPGPIEVPMNPIAIKR----------------------ALANLVVNAARYGNGWIKVSSGTE-GKRAWFQVE 367
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1672584895 509 DFGIGIDREDQERIFERFYRVDKARSrhSGGTGLGLAIVKDYVNLLGGTIKVESHP 564
Cdd:PRK09467 368 DDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKVELGNSE 421
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
362-574 |
3.08e-15 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 78.15 E-value: 3.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 362 FVGNVSHELKTPVTSLIGFTEtLLDGAKDDPKILNEFLLIMQKDAIRLDKLIREIIQLSKDEETAH--ETQTIHLATYFE 439
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTE-VAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNlqDVAEIPLEDLLQ 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 440 Q-IIQSYQPM----IEkkhLTLEMQQKEQSFTTQTELLYPIIKNLIENAIQYSKESEKIIIRYevdNQLTFSVQDFGIGI 514
Cdd:PRK10337 319 SaVMDIYHTAqqagID---VRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTL---NARNFTVRDNGPGV 392
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 515 DREDQERIFERFYRvdkARSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGstFTVTI 574
Cdd:PRK10337 393 TPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGG--FEAKV 447
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
469-574 |
7.68e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 70.57 E-value: 7.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 469 TELLYPIIKNLIENAIQYSKESEKIIIRYEVD-NQLTFSVQDFGIGIDREDQERIFERFYRVDKarSRHSGG-TGLGLAI 546
Cdd:cd16975 2 TLLLSRALINIISNACQYAPEGGTVSISIYDEeEYLYFEIWDNGHGFSEQDLKKALELFYRDDT--SRRSGGhYGMGLYI 79
|
90 100
....*....|....*....|....*...
gi 1672584895 547 VKDYVNLLGGTIKVESHPGMGSTFTVTI 574
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
470-575 |
3.95e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 68.58 E-value: 3.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 470 ELLYPIIKNLIENAIQYSKESEKIIIRYEV--DNQLTFSVQDFGIGIDREDQERIFERFYrvdkarSRHSGGTGLGLAIV 547
Cdd:cd16920 3 QVLINLVRNGIEAMSEGGCERRELTIRTSPadDRAVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 1672584895 548 KDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
349-576 |
4.42e-14 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 75.48 E-value: 4.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 349 LTKVRRLEKLQKdFVGNVSHELKTPVTSLIGFTETLLDGAKDDPKILNEFLLIMQKDAiRLDKLIREIIQLSKDEETAhe 428
Cdd:PRK13837 441 LEHARRLEAVGT-LASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGA-RARLIIDQILAFGRKGERN-- 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 429 TQTIHLATYFEQIIQ----SYQPMIEkkhLTLEMQQKEQSFTTQTELLYPIIKNLIENAIQYSKESEKIIIR-YEVDNQ- 502
Cdd:PRK13837 517 TKPFDLSELVTEIAPllrvSLPPGVE---LDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISlSRAKLRa 593
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 503 ---LT-----------FSVQDFGIGIDREDQERIFERFYrvdkarSRHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGS 568
Cdd:PRK13837 594 pkvLShgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGT 667
|
....*...
gi 1672584895 569 TFTVTIPP 576
Cdd:PRK13837 668 RFDVYLPP 675
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
478-575 |
6.39e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 68.20 E-value: 6.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 478 NLIENAIQYSKESE-KIIIRYEVDNQLTF-----------SVQDFGIGIDREDQERIFERFYrvdkarSRHSGGTGLGLA 545
Cdd:cd16918 7 NLVRNAAQALAGSGgEIILRTRTQRQVTLghprhrlalrvSVIDNGPGIPPDLQDTIFYPMV------SGRENGTGLGLA 80
|
90 100 110
....*....|....*....|....*....|
gi 1672584895 546 IVKDYVNLLGGTIKVESHPGMgSTFTVTIP 575
Cdd:cd16918 81 IAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
367-575 |
2.05e-13 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 73.24 E-value: 2.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 367 SHELKTPV----TSLigftETLLDGAKDDPKilNEFLLIMQKDAIRLDKLIREIIQLSKDEE--TAHETQTIHLATYFEQ 440
Cdd:TIGR03785 493 SHELRTPVavvrSSL----ENLELQALEQEK--QKYLERAREGTERLSMILNNMSEATRLEQaiQSAEVEDFDLSEVLSG 566
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 441 IIQSYQPMIEKKHLTLEMQQKEQSFTTQTELLYPIIKNLIENAIQYSKESEKIIIR-YEVDNQLTFSVQDFGIGIDREDQ 519
Cdd:TIGR03785 567 CMQGYQMTYPPQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGlSQNKSHALLTVSNEGPPLPEDMG 646
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1672584895 520 ERIFERFY--RVDKARSRHSggTGLGLAIVKDYVNLLGGTIKVESHP-GMGSTFTVTIP 575
Cdd:TIGR03785 647 EQLFDSMVsvRDQGAQDQPH--LGLGLYIVRLIADFHQGRIQAENRQqNDGVVFRISLP 703
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
471-565 |
9.31e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 64.79 E-value: 9.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 471 LLYPIIKNLIENAIQYSKESEKIIIRYEVD-NQLTFSVQDFGIGIDREDQERIFERFYRVDKArsrHSG--GTGLGLAIV 547
Cdd:cd16945 4 LLRQAINNLLDNAIDFSPEGGLIALQLEADtEGIELLVFDEGSGIPDYALNRVFERFYSLPRP---HSGqkSTGLGLAFV 80
|
90
....*....|....*...
gi 1672584895 548 KDYVNLLGGTIKVESHPG 565
Cdd:cd16945 81 QEVAQLHGGRITLRNRPD 98
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
362-575 |
1.33e-12 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 70.70 E-value: 1.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 362 FVGNVSHELKTPVTSLIGFTETLLD-----GAKDDPKILN---EFLLIMQKDAIRLDKLIREIIQLSKDEETAHETQTIh 433
Cdd:PRK11466 447 FLAAMSHEIRTPLYGILGTAQLLADnpalnAQRDDLRAITdsgESLLTILNDILDYSAIEAGGKNVSVSDEPFEPRPLL- 525
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 434 latyfEQIIQSYQPMIEKKHLTLEMQQKEQSFTT---QTELLYPIIKNLIENAIQYSKESEkIIIRYEVDNQLTF-SVQD 509
Cdd:PRK11466 526 -----ESTLQLMSGRVKGRPIRLATDIADDLPTAlmgDPRRIRQVITNLLSNALRFTDEGS-IVLRSRTDGEQWLvEVED 599
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1672584895 510 FGIGIDREDQERIFERFYRVDKARsrhsGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:PRK11466 600 SGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
439-574 |
1.48e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 64.96 E-value: 1.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 439 EQIIQSYQPMIEKKHLTLEMQ-QKEQSFTTQTELLYPIIKNLIENAIQYSKESEKIIIRYEvDNQLTFSVQDFGIGIDRE 517
Cdd:cd16954 4 DSLCSALNKVYQRKGVSISLDiSPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQT-DGGLHLIVDDDGPGVPES 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1672584895 518 DQERIFERFYRVDKARSrhsgGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTI 574
Cdd:cd16954 83 QRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
356-421 |
2.44e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 62.23 E-value: 2.44e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1672584895 356 EKLQKDFVGNVSHELKTPVTSLIGFTETLLDGAKDDPKiLNEFLLIMQKDAIRLDKLIREIIQLSK 421
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEE-QREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-575 |
3.62e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 62.98 E-value: 3.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 475 IIKNLIENAIQYSKESEKIII--RYEVDNQLTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGGTGLGLAIVKDYVN 552
Cdd:cd16953 4 VLRNLIGNAISFSPPDTGRITvsAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQIIE 83
|
90 100
....*....|....*....|....*..
gi 1672584895 553 LLGGTIKVESH--PGM--GSTFTVTIP 575
Cdd:cd16953 84 AHGGISVAENHnqPGQviGARFTVQLP 110
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
352-564 |
7.71e-12 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 66.92 E-value: 7.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 352 VRRL-EKLQKD--FVGNVSHELKTPvtsligftetlLDGAKddpkiLNefLLIMQKDAI--------RLDKLIREIIQL- 419
Cdd:PRK10755 127 VSRLtSTLDQErlFTADVAHELRTP-----------LAGIR-----LH--LELLEKQHHidvapliaRLDQMMHTVEQLl 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 420 ----SKDEETAHETQTIHLAtyfEQIIQSYQP----MIEKKHLTLEMQQKEQSFTTQ--TELLYPIIKNLIENAIQYSKE 489
Cdd:PRK10755 189 qlarAGQSFSSGHYQTVKLL---EDVILPSQDelseMLEQRQQTLLLPESAADITVQgdATLLRLLLRNLVENAHRYSPE 265
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1672584895 490 SEKIIIRYEVDNQ-LTFSVQDFGIGIDREDQERIFERFYRVDkarSRHsGGTGLGLAIVKDYVNLLGGTIKVESHP 564
Cdd:PRK10755 266 GSTITIKLSQEDGgAVLAVEDEGPGIDESKCGELSKAFVRMD---SRY-GGIGLGLSIVSRITQLHHGQFFLQNRQ 337
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
359-424 |
1.04e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 60.27 E-value: 1.04e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1672584895 359 QKDFVGNVSHELKTPVTSLIGFTETLLDGAKDDPKilNEFLLIMQKDAIRLDKLIREIIQLSKDEE 424
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ--REYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
359-424 |
1.53e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 59.92 E-value: 1.53e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1672584895 359 QKDFVGNVSHELKTPVTSLIGFTETLLDGAKDDPkiLNEFLLIMQKDAIRLDKLIREIIQLSKDEE 424
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEE--QREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
242-575 |
2.81e-11 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 65.10 E-value: 2.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 242 TTTEEQLYTLLNELMIGVFLIDSESHLRLLNPKMQAHLGvhdyQPNQRyteIIQEPkLIQLIHQVTPNEPLIHQEITISE 321
Cdd:PRK11073 3 TGTLPDAGQILNSLINSILLLDDDLAIHYANPAAQQLLA----QSSRK---LFGTP-LPELLSYFSLNIELMRESLQAGQ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 322 GQQTLDISLRYFNSS---EETGQILGVAYDLTKV------RRL--EKLQ-------KDFVGNVSHELKTPVTSLIGFTEt 383
Cdd:PRK11073 75 GFTDNEVTLVIDGRShilSLTAQRLPEGMILLEMapmdnqRRLsqEQLQhaqqvaaRDLVRGLAHEIKNPLGGLRGAAQ- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 384 LLDGAKDDPKiLNEFLLIMQKDAIRLDKLIREIiqLSKDEETAHETQTIHLATyfEQ--------------IIQSYQPMI 449
Cdd:PRK11073 154 LLSKALPDPA-LTEYTKVIIEQADRLRNLVDRL--LGPQRPGTHVTESIHKVA--ERvvqlvslelpdnvrLIRDYDPSL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 450 EKkhLTLEMQQKEQSFTtqtellypiikNLIENAIQ-YSKESEKIIIRYEVDNQLTF-----------SVQDFGIGIDRE 517
Cdd:PRK11073 229 PE--LAHDPDQIEQVLL-----------NIVRNALQaLGPEGGTITLRTRTAFQLTLhgeryrlaariDIEDNGPGIPPH 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1672584895 518 DQERIFerfYRVDKARSrhsGGTGLGLAIVKDYVNLLGGTIKVESHPGMgSTFTVTIP 575
Cdd:PRK11073 296 LQDTLF---YPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
501-575 |
4.58e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 57.39 E-value: 4.58e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1672584895 501 NQLTFSVQDFGIGIDREDQERIFERFYRVDKARSrhsgGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16919 46 NYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGK----GTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
365-575 |
6.08e-10 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 60.02 E-value: 6.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 365 NVSHELktpvTSLIGFTETLLDGAKDDPKILNEFLLIMQKDAIRLDKLIREIIQLSKDEETAHETQTIHLATYFEQIIQS 444
Cdd:COG4585 64 GVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVRGLRPPALDDLGLAAALEELAERLLRA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 445 YQPmiekkHLTLEMQQKEQSFTTQTEL-LYPIIKNLIENAIQYSKESE-KIIIRYEvDNQLTFSVQDFGIGIDREDQeri 522
Cdd:COG4585 140 AGI-----RVELDVDGDPDRLPPEVELaLYRIVQEALTNALKHAGATRvTVTLEVD-DGELTLTVRDDGVGFDPEAA--- 210
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1672584895 523 ferfyrvdkarsrhsGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:COG4585 211 ---------------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLP 248
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-572 |
8.47e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 53.23 E-value: 8.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 475 IIKNLIENAIQYSKESEKIIIRYEVDNQ---LTFSVQDFGIGIDREDQERIFERFYRvdkarSRHSG-GTGLGLAIVKDY 550
Cdd:cd16976 4 VLMNLLQNALDAMGKVENPRIRIAARRLggrLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISYGI 78
|
90 100
....*....|....*....|..
gi 1672584895 551 VNLLGGTIKVESHPGMGSTFTV 572
Cdd:cd16976 79 VEEHGGRLSVANEEGAGARFTF 100
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
479-575 |
1.42e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 57.34 E-value: 1.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 479 LIENAIQYSKESE----KIIIR-YEVDNQLTFSVQDFGIGIDREDQERIFERFyrvdkarSRHSGGTGLGLAIVKDYVNL 553
Cdd:COG2972 344 LVENAIEHGIEPKegggTIRISiRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKL 416
|
90 100
....*....|....*....|....*
gi 1672584895 554 L---GGTIKVESHPGMGSTFTVTIP 575
Cdd:COG2972 417 YygeEYGLEIESEPGEGTTVTIRIP 441
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
479-575 |
3.16e-08 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 53.74 E-value: 3.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 479 LIENAIQYSKESE------------KIIIRYEVD-NQLTFSVQDFGIGIDREdqeRIFErfyrvdKARSR---------- 535
Cdd:cd16916 46 LLRNAVDHGIEAPeerlaagkppegTITLRAEHQgNQVVIEVSDDGRGIDRE---KIRE------KAIERglitadeaat 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1672584895 536 -----------HSG-----------GTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16916 117 lsddevlnlifAPGfstaeqvtdvsGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
472-575 |
2.06e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 48.70 E-value: 2.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 472 LYPIIKNLIENAIQYSKESEKIIIRYEVDNQLTFSVQDFGIGIDREDqeriferfyrvdkarsrHSGGTGLGLAIVKDYV 551
Cdd:cd16917 1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPA-----------------PPGGGGFGLLGMRERA 63
|
90 100
....*....|....*....|....
gi 1672584895 552 NLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16917 64 ELLGGTLTIGSRPGGGTRVTARLP 87
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
478-564 |
2.40e-07 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 53.48 E-value: 2.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 478 NLIENAIQYSKESEKIIIRYEvDNQLTFSVQDFGIGIDREDQERIFERFYRVDKARSrhsgGTGLGLAIVKDYVNLLGGT 557
Cdd:PRK10815 385 NVLDNACKYCLEFVEISARQT-DEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGK 459
|
....*..
gi 1672584895 558 IKVESHP 564
Cdd:PRK10815 460 ISAGDSP 466
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
428-577 |
2.60e-07 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 53.37 E-value: 2.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 428 ETQTIHLATYFEQIIQSYQPMIEKKHLTLEMQQKEQSFTTQTELlyPI--IKN-LIENAIQY---SKESEKIIIRYEV-D 500
Cdd:COG3920 355 DWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVELPADAAV--PLglILNeLVTNALKHaflSGEGGRIRVSWRReD 432
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1672584895 501 NQLTFSVQDFGIGIDREdqeriferfyrVDKARSRhsggtGLGLAIVKDYVNLLGGTIKVESHPGMgsTFTVTIPPA 577
Cdd:COG3920 433 GRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQLGGTLELDRPEGT--RVRITFPLA 491
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
475-575 |
2.75e-07 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 53.30 E-value: 2.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 475 IIKNLIENAIQYS---KESEKIIIRYEVD--NQLTFSVQDFGIGIDREDQERIFERFYrvdKARSRHSGGTGLGLAIVKD 549
Cdd:PRK15053 436 IVGNLLDNAFEASlrsDEGNKIVELFLSDegDDVVIEVADQGCGVPESLRDKIFEQGV---STRADEPGEHGIGLYLIAS 512
|
90 100
....*....|....*....|....*.
gi 1672584895 550 YVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:PRK15053 513 YVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
478-575 |
5.05e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 48.30 E-value: 5.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 478 NLIENAIQYSKESE----KIIIRYEVD--NQLTFSVQDFGIGIDREDQERIFERfYRVDKARsrhsgGTGLGLAIVKDYV 551
Cdd:cd16944 11 NILKNAAEAIEGRPsdvgEVRIRVEADqdGRIVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTGLGLAIVKKIM 84
|
90 100
....*....|....*....|....
gi 1672584895 552 NLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:cd16944 85 EEHGGRISLSNREAGGACIRIILP 108
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
501-575 |
3.59e-06 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 49.80 E-value: 3.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 501 NQLTFSVQDFGIGIDREdqeRIFErfyrvdKARSR---------------------HSG-----------GTGLGLAIVK 548
Cdd:COG0643 320 GRVVIEVSDDGRGLDLE---KIRA------KAIEKglitaeeaaalsdeellelifAPGfstaeevtdlsGRGVGMDVVK 390
|
90 100
....*....|....*....|....*..
gi 1672584895 549 DYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:COG0643 391 TNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
362-548 |
4.72e-06 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 49.07 E-value: 4.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 362 FVGNVSHELKTPVTSLIGFTETLldgakDDPKILNEFLLIMQkdaiRLDKLIRE---IIQL-SKDEETahETQTIHLATY 437
Cdd:NF038389 209 FLRNIMHELKTPITKGRIVAEML-----EDEKQKERLISIFE----RLESLINEfakIEQLtSKNYKL--NKKEYRLSDI 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 438 FEQIIQSYqpMIEKKHLTLEMQQKEQSFTTQTELLYPIIKNLIENAIQYSKESeKIIIRYEvDNQLTFSvqDFGIGIDrE 517
Cdd:NF038389 278 IDEAIDML--MIDDSSVIIKVSLEDFKLNVDFELFSLAIKNLIDNAIKYSPDK-KVTIEIK-GDKIEFK--NKGEPLE-E 350
|
170 180 190
....*....|....*....|....*....|.
gi 1672584895 518 DQERIFERFYrvdKARSRHSGGTGLGLAIVK 548
Cdd:NF038389 351 PLEYYFEPFF---KGNEKSKSGFGLGLYIVK 378
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
353-575 |
1.01e-05 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 48.78 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 353 RRLEKLQ---KDFVGNVSHELKTPVTSLIGFTETL--LDGAKDDPKILNEFLLimqkDAIRLDKLIREIIQLSKDE--ET 425
Cdd:PRK10618 441 REYEKNQqarKAFLQNIGDELKQPLQSLAQLAAQLrqTSDEEQQQPELDQLAE----QSDVLVRLVDNIQLLNMLEtqDW 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 426 AHETQTIHLATYFEQIIQSYQPMIEKKHLTLEMQQK---EQSFTTQTELLYPIIKNLIENAI---QYSKESEKIIIRYEV 499
Cdd:PRK10618 517 KPEQELFSLQDLIDEVLPEVLPAIKRKGLQLLIHNHlkaEQLRIGDRDALRKILLLLLNYAItttAYGKITLEVDQDESS 596
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1672584895 500 DNQLTFSVQDFGIGIDREDQERIfeRFYRVDKARS-RHSGGTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:PRK10618 597 PDRLTIRILDTGAGVSIKELDNL--HFPFLNQTQGdRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLK 671
|
|
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
479-575 |
3.87e-05 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 46.02 E-value: 3.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 479 LIENAIQYSKESEK----IIIRYEV-DNQLTFSVQDFGIGIDREdqeriferfyrvdkarsRHSGGTGLGLAIVKDYVNL 553
Cdd:COG3275 261 LVENAIKHGISSKEgggtISISIEVeGDRLVIEVENNGVGIQPK-----------------KKKKGSGIGLKNVRERLEL 323
|
90 100
....*....|....*....|....*
gi 1672584895 554 LGG---TIKVESHPGMGSTFTVTIP 575
Cdd:COG3275 324 LYGdkySLEIESTDGGGTKVTLKIP 348
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
504-575 |
1.33e-04 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 44.66 E-value: 1.33e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1672584895 504 TFSVQDFGIGIDREDQERIFERFYRvdkarSRHSG-GTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTIP 575
Cdd:PRK13557 326 SIAVTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
479-575 |
4.46e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 40.28 E-value: 4.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 479 LIENAIQYS---KESEKIIIRYEV-DNQLTFSVQDFGIGIDREDQERIFErfyrvdkarsrHSGGTGLGLAIVKDYVNLL 554
Cdd:COG2172 42 AVTNAVRHAyggDPDGPVEVELELdPDGLEIEVRDEGPGFDPEDLPDPYS-----------TLAEGGRGLFLIRRLMDEV 110
|
90 100
....*....|....*....|.
gi 1672584895 555 GgtikVESHPGmGSTFTVTIP 575
Cdd:COG2172 111 E----YESDPG-GTTVRLVKR 126
|
|
| HATPase_TopVIB-like |
cd16933 |
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ... |
465-565 |
2.32e-03 |
|
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 39.64 E-value: 2.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 465 FTTQTELLYPIIKNLIENAIQYSKESE-----KIIIRYEVDNQLTFSVQDFGIGIDREDQERIFERFYRVDKARSRHSGG 539
Cdd:cd16933 13 FDNPIRSLYTTVRELVENSLDATEEAGilpdiKVEIEEIGKDHYKVIVEDNGPGIPEEQIPKVFGKVLYGSKYHNKQSRG 92
|
90 100
....*....|....*....|....*...
gi 1672584895 540 T-GLGLAIVKDYVNLLGGT-IKVESHPG 565
Cdd:cd16933 93 QqGLGISAAVLYSQMTTGKpVEIISSTK 120
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-575 |
4.02e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 37.78 E-value: 4.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 475 IIKNLIENAIQYS---KESEKIIIRYEVDN-QLTFSVQDFGIGIDREDqeriferfyrvDKARSrhsggTGLGLAIVKDY 550
Cdd:cd16951 43 VVNELLQNALKHAfsdREGGTITIRSVVDGdYLRITVIDDGVGLPQDE-----------DWPNK-----GSLGLQIVRSL 106
|
90 100
....*....|....*....|....*.
gi 1672584895 551 V-NLLGGTIKVEShPGMGSTFTVTIP 575
Cdd:cd16951 107 VeGELKAFLEVQS-AENGTRVNIDIP 131
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
471-569 |
4.96e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 38.09 E-value: 4.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 471 LLYPIIKNLIENAIQYSKESE------KIIIRYEvDNQLTFSVQDFGIGIDREDQERIFERFY----------RVDKARS 534
Cdd:cd16929 47 ILFELLKNAMRATVESHGDDSddlppiKVTVAKG-DEDLTIKISDRGGGIPREDLARLFSYMYstapqpslddFSDLISG 125
|
90 100 110
....*....|....*....|....*....|....*...
gi 1672584895 535 RHSG---GTGLGLAIVKDYVNLLGGTIKVESHPGMGST 569
Cdd:cd16929 126 TQPSplaGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTD 163
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
471-575 |
5.34e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 36.67 E-value: 5.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 471 LLYPIIKNLIENAIQYSKESE--KIIIRYEVDNQLTFSVQDFGIGIDREDQERIferfyrvdkaRSRHSGGTGLGLAIVK 548
Cdd:cd16955 5 MIQPLVENAIVHGIQEKKGKGvvKISVKKQLKNRLHIAVEDNGIGISPKVIERV----------EQDEMPGNKIGLLNVH 74
|
90 100
....*....|....*....|....*...
gi 1672584895 549 DYVNLLGGT-IKVESHPGMGSTFTVTIP 575
Cdd:cd16955 75 QRLKLGYGEgLHIRSRPDPGTLIAFYIP 102
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
454-575 |
5.37e-03 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 39.58 E-value: 5.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672584895 454 LTLEMQQKEQSFTTQ-------TEL-------LYPIIKNLIENAIQYSKESEKIIIRYEVDNQLTFSVQDFGIGIDredq 519
Cdd:PRK11644 379 LMREMELEDRGIVSHldwrideSALsetqrvtLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLP---- 454
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1672584895 520 eriferfyrvdkarsRHSGGTGLGLAIVKDYVNLLGGTIKVESHPgmGSTFTVTIP 575
Cdd:PRK11644 455 ---------------PGSGQQGFGLRGMRERVTALGGTLTISCTH--GTRLSVSLP 493
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
510-574 |
6.91e-03 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 37.05 E-value: 6.91e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1672584895 510 FGIGIDREDQERIFERFYRVDKARSRHSG--GTGLGLAIVKDYVNLLGGTIKVESHPGMGSTFTVTI 574
Cdd:cd16938 67 FEVEINDSGSPSIESASMRNSLNRRYNLSelGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| |
