|
Name |
Accession |
Description |
Interval |
E-value |
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
73-987 |
7.09e-162 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 494.46 E-value: 7.09e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 73 DMAKTYPFKLDPFQSVSVACLERKESILVSAHTSAGKTAVAEYAIAMAFRDKQRVIYTSPLKALSNQKYRELQHEF--KD 150
Cdd:COG4581 17 DFAEERGFELDPFQEEAILALEAGRSVLVAAPTGSGKTLVAEFAIFLALARGRRSFYTAPIKALSNQKFFDLVERFgaEN 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 151 VGLMTGDVTLSPNASCLVMTTEILRAMLYRGSEVLKEVAWVIFDEIHYMKDRERGVVWEESIIFLPPAIKMVFLSATMSN 230
Cdd:COG4581 97 VGLLTGDASVNPDAPIVVMTTEILRNMLYREGADLEDVGVVVMDEFHYLADPDRGWVWEEPIIHLPARVQLVLLSATVGN 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 231 ATEFAEWICYLHkQPCHVVYTDFRPTPL-QHYAFPMGGGGLYLVvddNEQFREdsfvkmqdtfpkpksndgkksangksg 309
Cdd:COG4581 177 AEEFAEWLTRVR-GETAVVVSEERPVPLeFHYLVTPRLFPLFRV---NPELLR--------------------------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 310 grgakggggpgDSDVYKIVKMIMERKFEPVIIFSFSRRECEQHALSMSKLDFNTDEEKEVVEQVFNNAmqclnEEDRSLP 389
Cdd:COG4581 226 -----------PPSRHEVIEELDRGGLLPAIVFIFSRRGCDEAAQQLLSARLTTKEERAEIREAIDEF-----AEDFSVL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 390 AIELMLPLLQRGIAVHHSGLLPVIKELVELLFQEGLVKALFATETFAMGLNMPAKTVVFTAVKKWDGDSHRYIGSGEYIQ 469
Cdd:COG4581 290 FGKTLSRLLRRGIAVHHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMPARTVVFTKLSKFDGERHRPLTAREFHQ 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 470 MSGRAGRRGKDERGICIIMIDEQMEMNTLRDMMLGKPAPLLSTFRLSYYTILNLLSRAEGQfTAEHVIRHSFHQFQHEKA 549
Cdd:COG4581 370 IAGRAGRRGIDTEGHVVVLAPEHDDPKKFARLASARPEPLRSSFRPSYNMVLNLLARPGLE-RARELLEDSFAQFQADRS 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 550 LPDIGNKVSKLEEEAAILNAS---GEAEVAEYHNLQFDIAKHEKklmseiIRPERVLCFLDtgrLVKIREGGTDwgwgvv 626
Cdd:COG4581 449 VVGLARRARELERALAGVVERlacDLGDLQEYFALRQPLSPLEA------LERESPAYALD---VVSVPEATLE------ 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 627 vnvvknssvgtgsasshgggyivdtllhcstgfsengakpkpcPPRagekgemhvvpvqlPLISALSRlrisvpsdlrpv 706
Cdd:COG4581 514 -------------------------------------------DPR--------------PVLLAQDR------------ 524
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 707 EARQSILLALQELssrfplgfpklhpvkdmniqdteiVDLVSQIEEVEQKLLAHPMHKSEDDQQIKSFQRKAEVNYEIQQ 786
Cdd:COG4581 525 RARGEAAAAMKAA------------------------IEYDERMERLEEVLRPHPLHECPLERAFELYRETHPWVRDIEL 580
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 787 L-KSKMRDsqLQKFRDelknrsrVLKKLGHIDaDGVVQVKGRAACLIDTgdellVTELMFNGTFNDLDHHQVAALASCFI 865
Cdd:COG4581 581 RpKSVARD--FDRFCE-------LLREYGYLD-DLTLTSEGLLLRYLYD-----AAEALRQGVPDDLDPEELAALISWLV 645
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 866 ----PVDKSNEQVNLRNELTKPLQQLQDSARKIAEIQHECKLEidveeyvestirPFLMDVIYSWSKGASFAEIIQMTDI 941
Cdd:COG4581 646 eevrRVDSSEWERLPSPANRRAFVLVNALFRRLELLERRHGLP------------ELDPGLAGAWASGADLAEVLDATDL 713
|
890 900 910 920
....*....|....*....|....*....|....*....|....*.
gi 1780597264 942 FEGSIIRSARRLDEFLNQLRAAAeavgessleskfAAASESLRRGI 987
Cdd:COG4581 714 DAGDFVRWVRQVIDPDPELRRTA------------RAAVDLIRRGV 747
|
|
| DEXHc_Mtr4-like |
cd18024 |
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ... |
43-254 |
1.78e-152 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350782 [Multi-domain] Cd Length: 205 Bit Score: 449.20 E-value: 1.78e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 43 CVHEVAVPNDYTPTKeetihgtLDNPVFNGDMAKTYPFKLDPFQSVSVACLERKESILVSAHTSAGKTAVAEYAIAMAFR 122
Cdd:cd18024 1 CTHEVALPPDYDYTP-------ISAHKPPGNPARTYPFTLDPFQKTAIACIERNESVLVSAHTSAGKTVVAEYAIAQSLR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 123 DKQRVIYTSPLKALSNQKYRELQHEFKDVGLMTGDVTLSPNASCLVMTTEILRAMLYRGSEVLKEVAWVIFDEIHYMKDR 202
Cdd:cd18024 74 DKQRVIYTSPIKALSNQKYRELQEEFGDVGLMTGDVTINPNASCLVMTTEILRSMLYRGSEIMREVAWVIFDEIHYMRDK 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1780597264 203 ERGVVWEESIIFLPPAIKMVFLSATMSNATEFAEWICYLHKQPCHVVYTDFR 254
Cdd:cd18024 154 ERGVVWEETIILLPDKVRYVFLSATIPNARQFAEWICKIHKQPCHVVYTDYR 205
|
|
| DEXHc_SKIV2L |
cd18027 |
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also ... |
75-251 |
1.65e-80 |
|
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also called SKI2 or DHX13) plays a role in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. SKIV2L belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350785 [Multi-domain] Cd Length: 179 Bit Score: 259.12 E-value: 1.65e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 75 AKTYPFKLDPFQSVSVACLERKESILVSAHTSAGKTAVAEYAIAMAFRDKQRVIYTSPLKALSNQKYRELQHEFKDVGLM 154
Cdd:cd18027 2 AFKWPFELDVFQKQAILHLEAGDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFKNTFGDVGLI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 155 TGDVTLSPNASCLVMTTEILRAMLYRGSEVLKEVAWVIFDEIHYMKDRERGVVWEESIIFLPPAIKMVFLSATMSNATEF 234
Cdd:cd18027 82 TGDVQLNPEASCLIMTTEILRSMLYNGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPDHVSIILLSATVPNTVEF 161
|
170
....*....|....*..
gi 1780597264 235 AEWICYLHKQPCHVVYT 251
Cdd:cd18027 162 ADWIGRIKKKNIYVIST 178
|
|
| rRNA_proc-arch |
pfam13234 |
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating ... |
534-793 |
6.68e-78 |
|
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating cofactor. This arch domain is carried in Mtr4 and Ski2 (the cytosolic homolog of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity.
Pssm-ID: 463813 Cd Length: 267 Bit Score: 255.67 E-value: 6.68e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 534 EHVIRHSFHQFQHEKALPDIGNKVSKLEEEAAILNASGEAEVAEYHNLQFDIAKHEKKLMSEIIRPERVLCFLDTGRLVK 613
Cdd:pfam13234 1 EYMLKRSFSQFQNQASLPELEKKLKELEKELASIKIPDEEDIKEYYDLRQQLEKLNEDIREVILHPPYGLPFLQPGRLVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 614 IR-EGGTDWGWGVVVNVVKNSsvGTGSASSHGGGYIVDTLLHCSTG---------FSENGAKPKPCPPraGEKGEMHVVP 683
Cdd:pfam13234 81 VKdNGDQDFGWGVVVNFKKRK--KNGKAEPPQESYIVDVLLVLALVsspedldkfNDVNPEGFRPAPP--GEKGEMEVVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 684 VQLPLISALSRLRISVPSDLRPVEARQSILLALQELSSRFPLGFPKLHPVKDMNIQDTEIVDLVSQIEEVEQKLLAHPMH 763
Cdd:pfam13234 157 VPLSDIEAISSVRLKLPKDLRPAEAREAVLKALQELKRRFPDGIPLLDPIEDMKIKDDEFKELLRKIEVLESRLESHPLH 236
|
250 260 270
....*....|....*....|....*....|.
gi 1780597264 764 KSED-DQQIKSFQRKAEVNYEIQQLKSKMRD 793
Cdd:pfam13234 237 KSPRlEELYALYHEKVELQEEIKELKKEISD 267
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
74-511 |
8.41e-75 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 255.98 E-value: 8.41e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 74 MAKTYPFKLDPFQSVSV-ACLERKESILVSAHTSAGKTAVAEYAIAMAFRDKQRVIYTSPLKALSNQKYRELQHEFKD-- 150
Cdd:COG1204 15 LKERGIEELYPPQAEALeAGLLEGKNLVVSAPTASGKTLIAELAILKALLNGGKALYIVPLRALASEKYREFKRDFEElg 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 151 --VGLMTGDVTLSP----NASCLVMTTEILRAMLYRGSEVLKEVAWVIFDEIHYMKDRERGVVWE---ESIIFLPPAIKM 221
Cdd:COG1204 95 ikVGVSTGDYDSDDewlgRYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAHLIDDESRGPTLEvllARLRRLNPEAQI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 222 VFLSATMSNATEFAEWIcylhkqPCHVVYTDFRPTPLQHYafpmgggglylVVDDNEqfredsfVKMQDTFPKPKsndgk 301
Cdd:COG1204 175 VALSATIGNAEEIAEWL------DAELVKSDWRPVPLNEG-----------VLYDGV-------LRFDDGSRRSK----- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 302 ksangksggrgakggggpgdsdvYKIVKMIME--RKFEPVIIFSFSRRECEQHALSMSKL--DFNTDEEKEVVEQVfnnA 377
Cdd:COG1204 226 -----------------------DPTLALALDllEEGGQVLVFVSSRRDAESLAKKLADElkRRLTPEEREELEEL---A 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 378 MQCLNEEDRSLPAIELmLPLLQRGIAVHHSGLLPVIKELVELLFQEGLVKALFATETFAMGLNMPAKTVVftaVKKWDGD 457
Cdd:COG1204 280 EELLEVSEETHTNEKL-ADCLEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVI---IRDTKRG 355
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1780597264 458 SHRYIGSGEYIQMSGRAGRRGKDERGICIIMIDEQMEMNTLRDM-MLGKPAPLLS 511
Cdd:COG1204 356 GMVPIPVLEFKQMAGRAGRPGYDPYGEAILVAKSSDEADELFERyILGEPEPIRS 410
|
|
| DSHCT |
pfam08148 |
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box ... |
820-987 |
9.58e-58 |
|
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases.
Pssm-ID: 462374 Cd Length: 154 Bit Score: 195.36 E-value: 9.58e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 820 GVVQVKGRAACLIDTGDELLVTELMFNGTFNDLDHHQVAALASCFIPVDKSNEQVNLRNELTKPLQQLQDSARKIAeiqh 899
Cdd:pfam08148 1 DVVTLKGRVACEIRSENELLLTELLFSGVFDDLDPEELAALLSAFVFEEKRREPYLPSPELAEALRLLEEIAHRIA---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 900 eckleidveeyVESTIRPFLMDVIYSWSKGASFAEIIQMTDIFEGSIIRSARRLDEFLNQLRAAAEAVGESSLESKFAAA 979
Cdd:pfam08148 77 -----------VSRFLDFGLMEVVYAWARGASFAEICKLTDLDEGDIVRLIRRLDELLRQIANAAKIIGDPELREKAEEA 145
|
....*...
gi 1780597264 980 SESLRRGI 987
Cdd:pfam08148 146 IELIKRDI 153
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
254-490 |
1.34e-57 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 195.08 E-value: 1.34e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 254 RPTPLQHYAFPMGGGGLYLVVDDNEQFredsfvkmqdtfpkpksndgkksangksggrgakggggpgDSDVYKIVKMIME 333
Cdd:cd18795 1 RPVPLEEYVLGFNGLGIKLRVDVMNKF----------------------------------------DSDIIVLLKIETV 40
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 334 RKFEPVIIFSFSRRECEQHALSMSkldfntdeekevveqvfnnamqclneedrslpaielmlpllqrGIAVHHSGLLPVI 413
Cdd:cd18795 41 SEGKPVLVFCSSRKECEKTAKDLA-------------------------------------------GIAFHHAGLTRED 77
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1780597264 414 KELVELLFQEGLVKALFATETFAMGLNMPAKTVVFTAVKKWDGDSHRYIGSGEYIQMSGRAGRRGKDERGICIIMID 490
Cdd:cd18795 78 RELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELSPLEYLQMIGRAGRPGFDTRGEAIIMTK 154
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
82-238 |
6.52e-55 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 188.62 E-value: 6.52e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 82 LDPFQSVSVACL-ERKESILVSAHTSAGKTAVAEYAIAMAFRD-KQRVIYTSPLKALSNQKYRELQHEF----KDVGLMT 155
Cdd:cd17921 2 LNPIQREALRALyLSGDSVLVSAPTSSGKTLIAELAILRALATsGGKAVYIAPTRALVNQKEADLRERFgplgKNVGLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 156 GDVTLS----PNASCLVMTTEILRAMLYRGSE-VLKEVAWVIFDEIHYMKDRERGVVWEESIIFLP---PAIKMVFLSAT 227
Cdd:cd17921 82 GDPSVNklllAEADILVATPEKLDLLLRNGGErLIQDVRLVVVDEAHLIGDGERGVVLELLLSRLLrinKNARFVGLSAT 161
|
170
....*....|.
gi 1780597264 228 MSNATEFAEWI 238
Cdd:cd17921 162 LPNAEDLAEWL 172
|
|
| KOW_Mtr4 |
cd13154 |
KOW_Mtr4 is an inserted domain in Mtr4 globular domain; Mtr4 is a conserved helicase with a ... |
605-731 |
6.90e-46 |
|
KOW_Mtr4 is an inserted domain in Mtr4 globular domain; Mtr4 is a conserved helicase with a core DExH region that cooperates with the eukaryotic nuclear exosome in RNA processing and degradation. KOW_Mtr4 motif might be involved in presenting RNA substrates to the helicase core. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW motif is located at the extended insertion of Mtr4 protein.
Pssm-ID: 240518 Cd Length: 129 Bit Score: 160.82 E-value: 6.90e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 605 FLDTGRLVKIREGGTDWGWGVVVNVVKNSSVGTGS-ASSHGGGYIVDTLLHCSTGFSENGAKP-KPCPPRAGEKGEMHVV 682
Cdd:cd13154 1 FLQPGRLVKVKVGDDDFGWGVVVNFQKRPNKKNGSeNSPPQESYVVDVLLNCSSGSSINNGSPsGIRPPGPGEKGEMEVV 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1780597264 683 PVQLPLISALSRLRISVPSDLRPVEARQSILLALQELSSRFPLGFPKLH 731
Cdd:cd13154 81 PVLLSLIQAISSIRLYLPKDLRSADARQSVGKSLQEVKRRFPDGLPLLD 129
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
80-525 |
9.26e-45 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 172.76 E-value: 9.26e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 80 FKLDPFQSVSVACLERKESILVSAHTSAGKTAVAEYAIAMAFRDKQRVIYTSPLKALSNQKYRELQHeFKDVGLMT---- 155
Cdd:PRK01172 21 FELYDHQRMAIEQLRKGENVIVSVPTAAGKTLIAYSAIYETFLAGLKSIYIVPLRSLAMEKYEELSR-LRSLGMRVkisi 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 156 GDVTLSP----NASCLVMTTEILRAMLYRGSEVLKEVAWVIFDEIHYMKDRERGVVWE---ESIIFLPPAIKMVFLSATM 228
Cdd:PRK01172 100 GDYDDPPdfikRYDVVILTSEKADSLIHHDPYIINDVGLIVADEIHIIGDEDRGPTLEtvlSSARYVNPDARILALSATV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 229 SNATEFAEWIcylhkqPCHVVYTDFRPTPLQHyafpmggGGLYlvvddneqfREDSFVkmqdtfpkpksnDGKKSAngks 308
Cdd:PRK01172 180 SNANELAQWL------NASLIKSNFRPVPLKL-------GILY---------RKRLIL------------DGYERS---- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 309 ggrgakggggpgDSDVYKIVKMIMERKFEpVIIFSFSRRECEQHALSMSKLdFNTDEEKEVVEQVFNNAMQCLNEedrsl 388
Cdd:PRK01172 222 ------------QVDINSLIKETVNDGGQ-VLVFVSSRKNAEDYAEMLIQH-FPEFNDFKVSSENNNVYDDSLNE----- 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 389 paielMLPllqRGIAVHHSGLLPVIKELVELLFQEGLVKALFATETFAMGLNMPAKTVVFTAVKKWDGDSHRYIGSGEYI 468
Cdd:PRK01172 283 -----MLP---HGVAFHHAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAGVNLPARLVIVRDITRYGNGGIRYLSNMEIK 354
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 469 QMSGRAGRRGKDERGICIIMIDEQMEMNTLRDMMLGKPAPLLSTF---RLSYYTILNLLS 525
Cdd:PRK01172 355 QMIGRAGRPGYDQYGIGYIYAASPASYDAAKKYLSGEPEPVISYMgsqRKVRFNTLAAIS 414
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
97-511 |
4.38e-37 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 149.97 E-value: 4.38e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 97 ESILVSAHTSAGKTAVAEyaIAMA---FRDKQRVIYTSPLKALSNQKYRELQhEFKDVGL----MTGDVTLSPN----AS 165
Cdd:PRK00254 40 KNLVLAIPTASGKTLVAE--IVMVnklLREGGKAVYLVPLKALAEEKYREFK-DWEKLGLrvamTTGDYDSTDEwlgkYD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 166 CLVMTTEILRAMLYRGSEVLKEVAWVIFDEIHYMKDRERGVVWEESIIFLPPAIKMVFLSATMSNATEFAEWIcylhkqP 245
Cdd:PRK00254 117 IIIATAEKFDSLLRHGSSWIKDVKLVVADEIHLIGSYDRGATLEMILTHMLGRAQILGLSATVGNAEELAEWL------N 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 246 CHVVYTDFRPTPLQHYAFPMGggglylvvddnEQFREDSFVkmqDTFPkpksndgkksangksggrgakgggGPGDSDVY 325
Cdd:PRK00254 191 AELVVSDWRPVKLRKGVFYQG-----------FLFWEDGKI---ERFP------------------------NSWESLVY 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 326 KIVKmimerKFEPVIIFSFSRRECEQHALSMSKL--DFNTDEEKEVVEQvfnnamqcLNEEDRSLPAIELMLPLLQRGIA 403
Cdd:PRK00254 233 DAVK-----KGKGALVFVNTRRSAEKEALELAKKikRFLTKPELRALKE--------LADSLEENPTNEKLKKALRGGVA 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 404 VHHSGLLPVIKELVELLFQEGLVKALFATETFAMGLNMPAKTVVFTAVKKWDGDSHRYIGSGEYIQMSGRAGRRGKDERG 483
Cdd:PRK00254 300 FHHAGLGRTERVLIEDAFREGLIKVITATPTLSAGINLPAFRVIIRDTKRYSNFGWEDIPVLEIQQMMGRAGRPKYDEVG 379
|
410 420
....*....|....*....|....*...
gi 1780597264 484 ICIIMIDEQMEMNTLRDMMLGKPAPLLS 511
Cdd:PRK00254 380 EAIIVATTEEPSKLMERYIFGKPEKLFS 407
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
91-483 |
6.48e-31 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 130.46 E-value: 6.48e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 91 ACLER----KESILVSAHTSAGKTAVAEYAIAMAFRDKQRVIYTSPLKALSNQKYRELQhEFK----DVGLMTGDVT--- 159
Cdd:PRK02362 30 EAVEAglldGKNLLAAIPTASGKTLIAELAMLKAIARGGKALYIVPLRALASEKFEEFE-RFEelgvRVGISTGDYDsrd 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 160 --LSPNaSCLVMTTEILRAMLYRGSEVLKEVAWVIFDEIHYMKDRERGVVWEESII---FLPPAIKMVFLSATMSNATEF 234
Cdd:PRK02362 109 ewLGDN-DIIVATSEKVDSLLRNGAPWLDDITCVVVDEVHLIDSANRGPTLEVTLAklrRLNPDLQVVALSATIGNADEL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 235 AEWIcylhkqPCHVVYTDFRPTPLQ---HYafpmgGGGLYLvvDDNEQF-----REDSFVKMQDTFpkpksNDGKKSang 306
Cdd:PRK02362 188 ADWL------DAELVDSEWRPIDLRegvFY-----GGAIHF--DDSQREvevpsKDDTLNLVLDTL-----EEGGQC--- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 307 ksggrgakggggpgdsdvykivkmimerkfepvIIFSFSRRECEQHA--LSMSKLDFNTDEEKEVVEQvfnnamqcLNEE 384
Cdd:PRK02362 247 ---------------------------------LVFVSSRRNAEGFAkrAASALKKTLTAAERAELAE--------LAEE 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 385 DRSLPAIELMLPL---LQRGIAVHHSGLLPVIKELVELLFQEGLVKALFATETFAMGLNMPAKTVVFTAVKKWDGDS-HR 460
Cdd:PRK02362 286 IREVSDTETSKDLadcVAKGAAFHHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRDYRRYDGGAgMQ 365
|
410 420
....*....|....*....|...
gi 1780597264 461 YIGSGEYIQMSGRAGRRGKDERG 483
Cdd:PRK02362 366 PIPVLEYHQMAGRAGRPGLDPYG 388
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
84-229 |
1.68e-30 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 118.11 E-value: 1.68e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 84 PFQSVSVACLERKESILVSAHTSAGKTAVAEYAIAMAFRDKQ---RVIYTSPLKALSNQKYRELQHEFKDVGL-----MT 155
Cdd:pfam00270 2 PIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDngpQALVLAPTRELAEQIYEELKKLGKGLGLkvaslLG 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1780597264 156 GDVTLS-----PNASCLVMTTEILRAMLYRgSEVLKEVAWVIFDEIHYMKDRERGVVWEESIIFLPPAIKMVFLSATMS 229
Cdd:pfam00270 82 GDSRKEqleklKGPDILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSATLP 159
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
79-261 |
2.59e-30 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 118.75 E-value: 2.59e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 79 PFKLDPFQSVSV-ACLERKESILVSAHTSAGKTAVAEYAIAMAFR--DKQRVIYTSPLKALSNQKYRELQHEFKD----- 150
Cdd:smart00487 6 FEPLRPYQKEAIeALLSGLRDVILAAPTGSGKTLAALLPALEALKrgKGGRVLVLVPTRELAEQWAEELKKLGPSlglkv 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 151 VGLMTGDVT-------LSPNASCLVMTTEILRAMLYRGSEVLKEVAWVIFDEIHYMKDRERGVVWEESIIFLPPAIKMVF 223
Cdd:smart00487 86 VGLYGGDSKreqlrklESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKNVQLLL 165
|
170 180 190
....*....|....*....|....*....|....*...
gi 1780597264 224 LSATMSNATEFAEWICYlhKQPCHVVYTDFRPTPLQHY 261
Cdd:smart00487 166 LSATPPEEIENLLELFL--NDPVFIDVGFTPLEPIEQF 201
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
81-238 |
1.11e-27 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 110.50 E-value: 1.11e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 81 KLDPFQSVSV-ACLERKESILVSAHTSAGKTAVAEYAIAMAFRDKQRVIYTSPLKALSNQKYRelqhEFKD-------VG 152
Cdd:cd18028 1 ELYPPQAEAVrAGLLKGENLLISIPTASGKTLIAEMAMVNTLLEGGKALYLVPLRALASEKYE----EFKKleeiglkVG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 153 LMTGD----VTLSPNASCLVMTTEILRAMLYRGSEVLKEVAWVIFDEIHYMKDRERGVVWeESII----FLPPAIKMVFL 224
Cdd:cd18028 77 ISTGDydedDEWLGDYDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTL-ESIVarlrRLNPNTQIIGL 155
|
170
....*....|....
gi 1780597264 225 SATMSNATEFAEWI 238
Cdd:cd18028 156 SATIGNPDELAEWL 169
|
|
| DEXHc_DDX60 |
cd18025 |
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an ... |
93-238 |
2.21e-24 |
|
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an IFN-inducible cytoplasmic helicase that plays a role in RIG-I-mediated type I interferon (IFN) nuclease-mediated viral RNA degradation. DDX60 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350783 [Multi-domain] Cd Length: 192 Bit Score: 101.68 E-value: 2.21e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 93 LERKESILVSAHTSAGKTAVAEYAIAMAFR--DKQRVIYTSPLKALSNQKYRELQHEFKD---------VGLMTGDVTLS 161
Cdd:cd18025 13 VDRRESALIVAPTSSGKTFISYYCMEKVLResDDGVVVYVAPTKALVNQVVAEVYARFSKkyppsgkslWGVFTRDYRHN 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 162 PNASCLVMTT--EILRAMLYRGS--EVLKEVAWVIFDEIHYMKDRERGVVWEESIIFLPPAIkmVFLSATMSNATEFAEW 237
Cdd:cd18025 93 NPMNCQVLITvpECLEILLLSPHnaSWVPRIKYVIFDEIHSIGQSEDGAVWEQLLLLIPCPF--LALSATIGNPQKFHEW 170
|
.
gi 1780597264 238 I 238
Cdd:cd18025 171 L 171
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
81-490 |
1.61e-20 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 97.65 E-value: 1.61e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 81 KLDPFQSVSVA--CLERKESILVSAhTSAGKTAVAEYA-IAMAFRDKQRVIYTSPLKALSNQKYRELQHEFK---DVGLM 154
Cdd:COG1202 209 ELLPVQSLAVEngLLEGKDQLVVSA-TATGKTLIGELAgIKNALEGKGKMLFLVPLVALANQKYEDFKDRYGdglDVSIR 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 155 TG-------DVTLSPNASCLVMTTEILRAMLyRGSEVLKEVAWVIFDEIHYMKDRERGVVWEESII---FLPPAIKMVFL 224
Cdd:COG1202 288 VGasrirddGTRFDPNADIIVGTYEGIDHAL-RTGRDLGDIGTVVIDEVHMLEDPERGHRLDGLIArlkYYCPGAQWIYL 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 225 SATMSNATEFAEwicylhKQPCHVVYTDFRPTPLQ-HYAFpmgggglylvVDDNEQfredsfvkmqdtfpkpksndgkks 303
Cdd:COG1202 367 SATVGNPEELAK------KLGAKLVEYEERPVPLErHLTF----------ADGREK------------------------ 406
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 304 angksggrgakggggpgdsdvYKIVKMIMERKFEPV---------IIFSFSRRECeqHALSmSKLDFNTdeekevveqvf 374
Cdd:COG1202 407 ---------------------IRIINKLVKREFDTKsskgyrgqtIIFTNSRRRC--HEIA-RALGYKA----------- 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 375 nnamqclneedrslpaielmlpllqrgiAVHHSGLLPVIKELVELLFQEGLVKALFATETFAMGLNMPAKTVVFTAV--- 451
Cdd:COG1202 452 ----------------------------APYHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDFPASQVIFDSLamg 503
|
410 420 430
....*....|....*....|....*....|....*....
gi 1780597264 452 KKWdgdshryIGSGEYIQMSGRAGRRGKDERGICIIMID 490
Cdd:COG1202 504 IEW-------LSVQEFHQMLGRAGRPDYHDRGKVYLLVE 535
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
97-238 |
2.49e-17 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 80.32 E-value: 2.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 97 ESILVSAHTSAGKT-AVAEYAIAMAFRDKQ---RVIYTSPLKALSNQKYRELQHEFKD------VGLMTGDVTLS----- 161
Cdd:cd17922 2 RNVLIAAPTGSGKTeAAFLPALSSLADEPEkgvQVLYISPLKALINDQERRLEEPLDEidleipVAVRHGDTSQSekakq 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 162 ----PNAscLVMTTEILRAMLY--RGSEVLKEVAWVIFDEIHYMKDRERGVVWEESII----FLPPAIKMVFLSATMSNA 231
Cdd:cd17922 82 lknpPGI--LITTPESLELLLVnkKLRELFAGLRYVVVDEIHALLGSKRGVQLELLLErlrkLTGRPLRRIGLSATLGNL 159
|
....*..
gi 1780597264 232 TEFAEWI 238
Cdd:cd17922 160 EEAAAFL 166
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
91-255 |
7.48e-17 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 80.09 E-value: 7.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 91 ACLERKESILVSAHTSAGKTAVAEYAIAMAFRD-------KQRVIYTSPLKALSNQKYRELQHEFKDVGL----MTGDVT 159
Cdd:cd18023 12 DLLYSDKNFVVSAPTGSGKTVLFELAILRLLKErnplpwgNRKVVYIAPIKALCSEKYDDWKEKFGPLGLscaeLTGDTE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 160 LSPN---ASC-LVMTT-EILRAMLYRGSE---VLKEVAWVIFDEIHYMKDrERGVVWE-----------ESIIFLPPAIK 220
Cdd:cd18023 92 MDDTfeiQDAdIILTTpEKWDSMTRRWRDngnLVQLVALVLIDEVHIIKE-NRGATLEvvvsrmktlssSSELRGSTVRP 170
|
170 180 190
....*....|....*....|....*....|....*....
gi 1780597264 221 MVF--LSATMSNATEFAEWicyLHKQP--CHVVYTDFRP 255
Cdd:cd18023 171 MRFvaVSATIPNIEDLAEW---LGDNPagCFSFGESFRP 206
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
97-238 |
1.65e-16 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 78.57 E-value: 1.65e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 97 ESILVSAHTSAGKTAVAEYAIAMAFRD--KQRVIYTSPLKALSNQKYRELQHEFKDV-GL----MTGDVTLSP----NAS 165
Cdd:cd18022 18 NNVLLGAPTGSGKTIAAELAMFRAFNKypGSKVVYIAPLKALVRERVDDWKKRFEEKlGKkvveLTGDVTPDMkalaDAD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 166 CLVMTTE----ILRAMLYRgsEVLKEVAWVIFDEIHYMKDrERGVVWEesII-----FLPP----AIKMVFLSATMSNAT 232
Cdd:cd18022 98 IIITTPEkwdgISRSWQTR--EYVQQVSLIIIDEIHLLGS-DRGPVLE--VIvsrmnYISSqtekPVRLVGLSTALANAG 172
|
....*.
gi 1780597264 233 EFAEWI 238
Cdd:cd18022 173 DLANWL 178
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
97-227 |
6.44e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 70.12 E-value: 6.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 97 ESILVSAHTSAGKTAVAEYAIAMAFRDKQ-RVIYTSPLKALSNQKYRELQHEFK---DVGLMTGDVTLS-------PNAS 165
Cdd:cd00046 2 ENVLITAPTGSGKTLAALLAALLLLLKKGkKVLVLVPTKALALQTAERLRELFGpgiRVAVLVGGSSAEereknklGDAD 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1780597264 166 CLVMTTE-ILRAMLYRGSEVLKEVAWVIFDEIHYMKDRERGVVWEESII--FLPPAIKMVFLSAT 227
Cdd:cd00046 82 IIIATPDmLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVrkAGLKNAQVILLSAT 146
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
391-478 |
1.63e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 66.85 E-value: 1.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 391 IELMLPLLQRGIAVHHSGLLPVIKELVELLFQEGLVKALFATETFAMGLNMPAKTVVFtavkkwdgDSHRYIGSGEYIQM 470
Cdd:smart00490 3 LAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVI--------IYDLPWSPASYIQR 74
|
....*...
gi 1780597264 471 SGRAGRRG 478
Cdd:smart00490 75 IGRAGRAG 82
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
86-255 |
2.67e-12 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 66.86 E-value: 2.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 86 QSVSVACLERKESILVSAHTSAGKTAVAEYAIAMAFRDKQR-VIYTSPLKALSNQKYRELQHEFKDVGL----MTGDVTL 160
Cdd:cd18026 23 ECLSLPGLLEGRNLVYSLPTSGGKTLVAEILMLKRLLERRKkALFVLPYVSIVQEKVDALSPLFEELGFrvegYAGNKGR 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 161 SPNA-----SCLVMTTEILRAMLYRGSE--VLKEVAWVIFDEIHYMKDRERGVVWE---ESIIFLPPA-IKMVFLSATMS 229
Cdd:cd18026 103 SPPKrrkslSVAVCTIEKANSLVNSLIEegRLDELGLVVVDELHMLGDGHRGALLElllTKLLYAAQKnIQIVGMSATLP 182
|
170 180
....*....|....*....|....*.
gi 1780597264 230 NATEFAEWicyLHKQpchVVYTDFRP 255
Cdd:cd18026 183 NLEELASW---LRAE---LYTTNFRP 202
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
68-238 |
1.35e-10 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 61.51 E-value: 1.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 68 PVFNgdmaktyPFKLDPFQSVsvacLERKESILVSAHTSAGKTAVAEYAIAMAFR--DKQRVIYTSPLKALSNQKYRELQ 145
Cdd:cd18021 2 KFFN-------PIQTQVFNSL----YNTDDNVFVGAPTGSGKTVCAELALLRHWRqnPKGRAVYIAPMQELVDARYKDWR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 146 HEF-----KDVGLMTGDVTLSPN---ASCLVMTTEILRAML---YRGSEVLKEVAWVIFDEIHyMKDRERGVVWE---ES 211
Cdd:cd18021 71 AKFgpllgKKVVKLTGETSTDLKllaKSDVILATPEQWDVLsrrWKQRKNVQSVELFIADELH-LIGGENGPVYEvvvSR 149
|
170 180 190
....*....|....*....|....*....|.
gi 1780597264 212 IIF----LPPAIKMVFLSATMSNATEFAEWI 238
Cdd:cd18021 150 MRYissqLEKPIRIVGLSSSLANARDVGEWL 180
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
84-257 |
1.44e-10 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 65.51 E-value: 1.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 84 PFQSVSVACLERKESILVSAHTSAGKT------AVAEYA---IAMAFRDKQRVIYTSPLKALSNQKYR-------ELQHE 147
Cdd:COG1201 27 PPQREAWPAIAAGESTLLIAPTGSGKTlaaflpALDELArrpRPGELPDGLRVLYISPLKALANDIERnlrapleEIGEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 148 FKD------VGLMTGDVTLS---------PNasCLVMTTEILRAMLY--RGSEVLKEVAWVIFDEIHYMKDRERGVVWEE 210
Cdd:COG1201 107 AGLplpeirVGVRTGDTPASerqrqrrrpPH--ILITTPESLALLLTspDARELLRGVRTVIVDEIHALAGSKRGVHLAL 184
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1780597264 211 SI----IFLPPAIKMVFLSATMSNATEFAEWIC-YLHKQPCHVVYTDFRPTP 257
Cdd:COG1201 185 SLerlrALAPRPLQRIGLSATVGPLEEVARFLVgYEDPRPVTIVDAGAGKKP 236
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
85-480 |
6.24e-09 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 59.85 E-value: 6.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 85 FQSVSVACLERKESILVSAHTSAGKTAVaeY---AIAMAFRDKQ-RVIYTSPLKALSNQKYRELQHEFKDVGL------M 154
Cdd:COG1205 60 HQAEAIEAARAGKNVVIATPTASGKSLA--YllpVLEALLEDPGaTALYLYPTKALARDQLRRLRELAEALGLgvrvatY 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 155 TGDVTLSP------NASCLVMTTEIL-RAMLYRG---SEVLKEVAWVIFDEIH-YmkdreRGV----V-WeesII----- 213
Cdd:COG1205 138 DGDTPPEErrwireHPDIVLTNPDMLhYGLLPHHtrwARFFRNLRYVVIDEAHtY-----RGVfgshVaN---VLrrlrr 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 214 ---FLPPAIKMVFLSATMSNATEFAEwicYLHKQPCHVVYTDFRPTPLQHYAFpmgggglylvvddneqfredsfvkmqd 290
Cdd:COG1205 210 icrHYGSDPQFILASATIGNPAEHAE---RLTGRPVTVVDEDGSPRGERTFVL--------------------------- 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 291 TFPKPKSNDGKKSANgksggrgakggggpgdSDVYKIVKMIMERKFePVIIFSFSRReceqhalsmskldfntdeekeVV 370
Cdd:COG1205 260 WNPPLVDDGIRRSAL----------------AEAARLLADLVREGL-RTLVFTRSRR---------------------GA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 371 EQVFNNAmqclneedrslpAIELMLPLLQRGIAVHHSGLLPVIKELVELLFQEGLVKALFATETFAMGLNMPAKTVVFTA 450
Cdd:COG1205 302 ELLARYA------------RRALREPDLADRVAAYRAGYLPEERREIERGLRSGELLGVVSTNALELGIDIGGLDAVVLA 369
|
410 420 430
....*....|....*....|....*....|.
gi 1780597264 451 vkkwdGdshrYIGS-GEYIQMSGRAGRRGKD 480
Cdd:COG1205 370 -----G----YPGTrASFWQQAGRAGRRGQD 391
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
81-235 |
9.08e-09 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 56.61 E-value: 9.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 81 KLDPFQS-VSVACLERKESILVSAHTSAGKTAVAEYAIAMAFR-----------DKQRVIYTSPLKALSNQKYRELQHEF 148
Cdd:cd18019 17 SLNRIQSkLFPAAFETDENLLLCAPTGAGKTNVALLTILREIGkhrnpdgtinlDAFKIVYIAPMKALVQEMVGNFSKRL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 149 KDVGL----MTGDVTLS----PNASCLVMTTE----ILRAMLYRGSEVLkeVAWVIFDEIHYMKDrERGVVWeESII--- 213
Cdd:cd18019 97 APYGItvaeLTGDQQLTkeqiSETQIIVTTPEkwdiITRKSGDRTYTQL--VRLIIIDEIHLLHD-DRGPVL-ESIVart 172
|
170 180
....*....|....*....|....*..
gi 1780597264 214 -----FLPPAIKMVFLSATMSNATEFA 235
Cdd:cd18019 173 irqieQTQEYVRLVGLSATLPNYEDVA 199
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
427-478 |
1.45e-08 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 54.10 E-value: 1.45e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1780597264 427 KALFATETFAMGLNMPAKTVVFTAVKKWDGDSHRYIGSGEYIQMSGRAGRRG 478
Cdd:cd18805 72 DVLVASDAIGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGRFG 123
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
101-238 |
1.91e-08 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 58.78 E-value: 1.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 101 VSAHTSAGKTAVA-EYAIAMAFRDK------------QRVIYTSPLKALSNQKYRELQHEFK----------------DV 151
Cdd:PRK09751 1 VIAPTGSGKTLAAfLYALDRLFREGgedtreahkrktSRILYISPIKALGTDVQRNLQIPLKgiaderrrrgetevnlRV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 152 GLMTGDVTLSPNA-------SCLVMTTEILRAMLY-RGSEVLKEVAWVIFDEIHYMKDRERG----VVWEESIIFLPPAI 219
Cdd:PRK09751 81 GIRTGDTPAQERSkltrnppDILITTPESLYLMLTsRARETLRGVETVIIDEVHAVAGSKRGahlaLSLERLDALLHTSA 160
|
170
....*....|....*....
gi 1780597264 220 KMVFLSATMSNATEFAEWI 238
Cdd:PRK09751 161 QRIGLSATVRSASDVAAFL 179
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
326-478 |
6.02e-08 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 51.83 E-value: 6.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 326 KIVKMIMERKFEPVIIFSFSRRECEqhalsmskldfntdeekevveqvfnnamqclneedrslpaIELMLPLLQRGIAVH 405
Cdd:pfam00271 5 ALLELLKKERGGKVLIFSQTKKTLE----------------------------------------AELLLEKEGIKVARL 44
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1780597264 406 HSGLLPVIKELVELLFQEGLVKALFATETFAMGLNMP-AKTVVFtavkkWDGDShryiGSGEYIQMSGRAGRRG 478
Cdd:pfam00271 45 HGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPdVDLVIN-----YDLPW----NPASYIQRIGRAGRAG 109
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
96-238 |
8.43e-08 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 53.59 E-value: 8.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 96 KESILVSAHTSAGKTAVAEYAIAMAF-----------RDKQRVIYTSPLKALSNQKYRELQHEFKDVGL----MTGDVTL 160
Cdd:cd18020 17 NENMLICAPTGAGKTNIAMLTILHEIrqhvnqggvikKDDFKIVYIAPMKALAAEMVEKFSKRLAPLGIkvkeLTGDMQL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 161 SPN----ASCLVMTTEILRAMLYRGS---EVLKEVAWVIFDEIHYMKDrERGVVWE----------ESIIFLppaIKMVF 223
Cdd:cd18020 97 TKKeiaeTQIIVTTPEKWDVVTRKSSgdvALSQLVRLLIIDEVHLLHD-DRGPVIEslvartlrqvESTQSM---IRIVG 172
|
170
....*....|....*
gi 1780597264 224 LSATMSNATEFAEWI 238
Cdd:cd18020 173 LSATLPNYLDVADFL 187
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
97-253 |
1.25e-07 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 55.66 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 97 ESILVSAHTSAGKTAVAEYAI-----AMAFR----DKQRVIYTSPLKALSN--------------QKYRELQHEFKD--V 151
Cdd:PRK13767 48 KNVLISSPTGSGKTLAAFLAIidelfRLGREgeleDKVYCLYVSPLRALNNdihrnleeplteirEIAKERGEELPEirV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 152 GLMTGDVTLSPNASCLVMTTEILR------AMLY---RGSEVLKEVAWVIFDEIHYMKDRERGVVWEESIIFLPPAIKMV 222
Cdd:PRK13767 128 AIRTGDTSSYEKQKMLKKPPHILIttpeslAILLnspKFREKLRTVKWVIVDEIHSLAENKRGVHLSLSLERLEELAGGE 207
|
170 180 190
....*....|....*....|....*....|....*....
gi 1780597264 223 F----LSATMSNATEFAEWI--CYLHKQP--CHVVYTDF 253
Cdd:PRK13767 208 FvrigLSATIEPLEEVAKFLvgYEDDGEPrdCEIVDARF 246
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
86-236 |
1.35e-07 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 52.59 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 86 QSVSVACLERKESILVSAHTSAGKTAVaeY---AIAMAFRDKQ-RVIYTSPLKALSN---QKYRELQHEFK---DVGLMT 155
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLC--YqlpILEALLRDPGsRALYLYPTKALAQdqlRSLRELLEQLGlgiRVATYD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 156 GD-------VTLSPNASCLVMTTEILRAMLYRGSE----VLKEVAWVIFDEIHY---------------MKDRERgvvwe 209
Cdd:cd17923 83 GDtpreerrAIIRNPPRILLTNPDMLHYALLPHHDrwarFLRNLRYVVLDEAHTyrgvfgshvalllrrLRRLCR----- 157
|
170 180
....*....|....*....|....*..
gi 1780597264 210 esiiFLPPAIKMVFLSATMSNATEFAE 236
Cdd:cd17923 158 ----RYGADPQFILTSATIGNPAEHAR 180
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
75-212 |
3.12e-07 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 51.65 E-value: 3.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 75 AKTYPFKLDPFQSVS---VAC-LERKESI--LVSAHTSAGKTAVAEYAIAMAFRDKQRVIYTSPLKALSNQKYRELQHEF 148
Cdd:cd17918 9 CKSLPFSLTKDQAQAikdIEKdLHSPEPMdrLLSGDVGSGKTLVALGAALLAYKNGKQVAILVPTEILAHQHYEEARKFL 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1780597264 149 KD--VGLMTGDVT--LSPNASCLVMTTEILRAmlyrgSEVLKEVAWVIFDEIHYMkdrerGVVWEESI 212
Cdd:cd17918 89 PFinVELVTGGTKaqILSGISLLVGTHALLHL-----DVKFKNLDLVIVDEQHRF-----GVAQREAL 146
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
71-227 |
3.19e-06 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 51.18 E-value: 3.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 71 NGDMAKTYPFKLDPFQ-----SVSVACLERKESILVSAHTSAGKTAVAEYAIAmAFRDKQRVIYTSPLKALSNQKYRELQ 145
Cdd:COG1061 70 AGDEASGTSFELRPYQqealeALLAALERGGGRGLVVAPTGTGKTVLALALAA-ELLRGKRVLVLVPRRELLEQWAEELR 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 146 HEFKDVGLMTGDVtlSPNASCLVMTTEILRAMLYRgSEVLKEVAWVIFDEIHYMkdreRGVVWEESIIFLPPAiKMVFLS 225
Cdd:COG1061 149 RFLGDPLAGGGKK--DSDAPITVATYQSLARRAHL-DELGDRFGLVIIDEAHHA----GAPSYRRILEAFPAA-YRLGLT 220
|
..
gi 1780597264 226 AT 227
Cdd:COG1061 221 AT 222
|
|
| DEXQc_Suv3 |
cd17913 |
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ... |
105-208 |
1.47e-05 |
|
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350671 [Multi-domain] Cd Length: 142 Bit Score: 45.63 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 105 TSAGKTavaeYAIAMAFRDKQRVIYTSPLKALSNQKYRELQHEFKDVGLMTGD-VTLSPNASCLVMTTEilraMLYRGSE 183
Cdd:cd17913 10 TNSGKT----YHALQRLKSAKSGVYCGPLRLLAWEVYERLNAEGVPCDLVTGQeRREVEGATHVSCTVE----MASISEP 81
|
90 100
....*....|....*....|....*
gi 1780597264 184 VlkEVAwVIfDEIHYMKDRERGVVW 208
Cdd:cd17913 82 Y--DVA-VI-DEIQMIGDPQRGWAW 102
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
100-227 |
1.70e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 45.76 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 100 LVSAHTSAGKTAVAEYAIAMAFrdKQRVIYTSPLKALSNQKYRELQHEFKD--VGLMTGDVTLSPNASCLVMTT-EILRA 176
Cdd:cd17926 22 ILVLPTGSGKTLTALALIAYLK--ELRTLIVVPTDALLDQWKERFEDFLGDssIGLIGGGKKKDFDDANVVVATyQSLSN 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1780597264 177 MLYRGSEVLKEVAWVIFDEIHymkdRERGVVWEEsIIFLPPAIKMVFLSAT 227
Cdd:cd17926 100 LAEEEKDLFDQFGLLIVDEAH----HLPAKTFSE-ILKELNAKYRLGLTAT 145
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
91-231 |
3.35e-05 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 45.40 E-value: 3.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 91 ACLERKESILVSAHTSAGKTAVAEYAIAMAFRDK-QRVIYTSP----LKALSNQKYRELQHEFKD-VGL-MTGDVTLSPN 163
Cdd:cd17990 12 AALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAgGKIIVLEPrrvaARAAARRLATLLGEAPGEtVGYrVRGESRVGRR 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1780597264 164 ASCLVMTTEILRAMLYRGSEvLKEVAWVIFDEIHymkdrERGV--------VWEESIIFLPPaIKMVFLSATMSNA 231
Cdd:cd17990 92 TRVEVVTEGVLLRRLQRDPE-LSGVGAVILDEFH-----ERSLdadlalalLLEVQQLLRDD-LRLLAMSATLDGD 160
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
84-237 |
5.31e-05 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 45.27 E-value: 5.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 84 PFQSVSVACLERKESILVSAHTSAGKTAVaeYAIAMAFRDKQ-------RVIYTSPLKALSNQKYRELQ-----HEFKdV 151
Cdd:cd17957 15 PIQMQAIPILLHGRDLLACAPTGSGKTLA--FLIPILQKLGKprkkkglRALILAPTRELASQIYRELLklskgTGLR-I 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 152 GLMTG--------DVTLSPNASCLVMTTEILRAMLYRGSEVLKEVAWVIFDEihymKDR--ERGVVWEESIIFLP---PA 218
Cdd:cd17957 92 VLLSKsleakakdGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDE----ADKlfEPGFREQTDEILAActnPN 167
|
170
....*....|....*....
gi 1780597264 219 IKMVFLSATMSNATEfaEW 237
Cdd:cd17957 168 LQRSLFSATIPSEVE--EL 184
|
|
| DEXDc_ComFA |
cd17925 |
DEXD-box helicase domain of ComFA; ATP-dependent helicase ComFA (also called ComF operon ... |
86-196 |
2.06e-04 |
|
DEXD-box helicase domain of ComFA; ATP-dependent helicase ComFA (also called ComF operon protein 1) is part of the complex mediating the binding and uptake of single-stranded DNA. ComFA is required for DNA uptake but not for binding. It belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350683 [Multi-domain] Cd Length: 143 Bit Score: 42.67 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 86 QSVSVACLE---RKESILVSAHTSAGKTAVAEYAIAMAFRDKQRVIYTSPLKALSNQKYRELQHEF--KDVGLMTGDVTL 160
Cdd:cd17925 3 QKASNALVEtidAKEDLLVWAVTGAGKTEMLFPAIAQALRQGGRVAIASPRIDVCLELAPRLKAAFpgAAIVLLHGGSED 82
|
90 100 110
....*....|....*....|....*....|....*...
gi 1780597264 161 SPNASCLVMTT--EILRamLYRGSEVLkevawvIFDEI 196
Cdd:cd17925 83 QYQRSPLVIATthQLLR--FYRAFDLL------IIDEV 112
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
427-487 |
8.28e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 38.84 E-value: 8.28e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1780597264 427 KALFATETFAMGLNMP-AKTVVFTAVKKWdgdshryigSGEYIQMSGRAGRRGKDErGICII 487
Cdd:cd18785 24 EILVATNVLGEGIDVPsLDTVIFFDPPSS---------AASYIQRVGRAGRGGKDE-GEVIL 75
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
99-236 |
1.49e-03 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 40.14 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 99 ILVSAHTSAGKT-----AVAEYAIAMafRDKQRVIYTSP--------LKALSNQKYRELQHEfkdVGLMT-GDVTLSPNA 164
Cdd:cd17917 4 VVIVGETGSGKTtqvpqFLLEDGLAK--GGKGRIVCTQPrriaaisvAERVAEERGEKLGEE---VGYQIrFESKTSSKT 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1780597264 165 SCLVMTTEILRAMLYRGSEvLKEVAWVIFDEIHymkdrERGV------VWEESIIFLPPAIKMVFLSATMsNATEFAE 236
Cdd:cd17917 79 RIKFCTDGILLRELLSDPL-LSGYSHVILDEAH-----ERSLdtdfllGLLKDLLRKRPDLKVILMSATL-DAEKFSS 149
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
80-197 |
2.11e-03 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 40.49 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 80 FKLDPFQSVSVACLERKESILVSAHTSAGKTAVAEYaIAMAFRDKQRVIYTSPLKALSNQKYRELQH---EFK------- 149
Cdd:cd17927 1 FKPRNYQLELAQPALKGKNTIICLPTGSGKTFVAVL-ICEHHLKKFPAGRKGKVVFLANKVPLVEQQkevFRKhferpgy 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1780597264 150 DVGLMTGDVTLS-------PNASCLVMTTEILRAMLYRGSEV-LKEVAWVIFDEIH 197
Cdd:cd17927 80 KVTGLSGDTSENvsveqivESSDVIIVTPQILVNDLKSGTIVsLSDFSLLVFDECH 135
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
370-480 |
2.65e-03 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 39.16 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 370 VEQVFNNAMQCLNEEDRslpaielmlplLQRGIAVHHSGLLPVIKELVELLFQEGLVKALFATETFAMGLNMPAKTVVFT 449
Cdd:cd18797 48 AELLLRYLKARLVEEGP-----------LASKVASYRAGYLAEDRREIEAELFNGELLGVVATNALELGIDIGGLDAVVL 116
|
90 100 110
....*....|....*....|....*....|.
gi 1780597264 450 AvkkwdGDSHRYIGsgeYIQMSGRAGRRGKD 480
Cdd:cd18797 117 A-----GYPGSLAS---LWQQAGRAGRRGKD 139
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
734-984 |
3.95e-03 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 40.90 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 734 KDMNIQDTEIVDLVSQIEEVEQKLlahpmhkSEDDQQIKSFQRK-AEVNYEIQQLKSKMRD--SQLQKFRDELKNRSRVL 810
Cdd:COG4942 41 KELAALKKEEKALLKQLAALERRI-------AALARRIRALEQElAALEAELAELEKEIAElrAELEAQKEELAELLRAL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 811 KKLGHIDadgvvqvkgRAACLIDTGDEL-LVTELMFNGTFNDLDHHQVAALAScfipvdKSNEQVNLRNELTKPLQQLQD 889
Cdd:COG4942 114 YRLGRQP---------PLALLLSPEDFLdAVRRLQYLKYLAPARREQAEELRA------DLAELAALRAELEAERAELEA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 890 SARKIAEIQHECKLEIDVEEYVESTIRPflmdviyswSKGASFAEIIQMtdifegsiIRSARRLDEFLNQLRAAAEAVGE 969
Cdd:COG4942 179 LLAELEEERAALEALKAERQKLLARLEK---------ELAELAAELAEL--------QQEAEELEALIARLEAEAAAAAE 241
|
250
....*....|....*
gi 1780597264 970 SSLESKFAAASESLR 984
Cdd:COG4942 242 RTPAAGFAALKGKLP 256
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
397-507 |
8.41e-03 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 40.08 E-value: 8.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780597264 397 LLQRGIAV--HHSGLLPVIKELVELLFQEGLVKALFATETFAMGLNMPakTVVFTAvkkwDGDSHRYIGSgeYIQMSGRA 474
Cdd:PRK11057 256 LQSRGISAaaYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKP--NVRFVV----HFDIPRNIES--YYQETGRA 327
|
90 100 110
....*....|....*....|....*....|...
gi 1780597264 475 GRRGKDERGiciIMIDEQMEMNTLRDMMLGKPA 507
Cdd:PRK11057 328 GRDGLPAEA---MLFYDPADMAWLRRCLEEKPA 357
|
|
| |
