|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
462-772 |
3.04e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 97.70 E-value: 3.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 462 SNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDF 541
Cdd:COG4886 3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 542 DN----ASALTELSDLEVLDLSYNshyfriagvthhlEFIQNFTNLKVLNLSHNNIYTLTDK-YNLesKSLVELVFSGNR 616
Cdd:COG4886 83 SLlllgLTDLGDLTNLTELDLSGN-------------EELSNLTNLESLDLSGNQLTDLPEElANL--TNLKELDLSNNQ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 617 LDILWNDddnryisiFKGLKNLTRLDLSLNRLKHIPNEaFLNLPaSLTELHINDNMLKFFNWTlLQQFPRLELLDLRGNK 696
Cdd:COG4886 148 LTDLPEP--------LGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQ 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2491161119 697 LLFLTDSLSDFTsSLRTLLLSHNRISHLPSgfLSEVSSLKHLDLSSNLLKTINKSAletkTTTKLSMLELHGNPFE 772
Cdd:COG4886 217 LTDLPEPLANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA----NLTNLKTLDLSNNQLT 285
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
877-1019 |
2.42e-16 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 76.59 E-value: 2.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 877 YDAYISYdtkdaSVTDWVINELRYHLEESRDKNVLlCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTA 956
Cdd:smart00255 2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2491161119 957 FYLALQRLMDENMDVIIFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEglFWQTLRNVV 1019
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWKKALYAV 137
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
570-771 |
3.75e-13 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 69.81 E-value: 3.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 570 VTH------HLEFIQNF---TNLKVLNLSHNNIYTLTdkyNLES-KSLVELVFSGNRLDILWNdddnryisiFKGLKNLT 639
Cdd:cd21340 4 ITHlylndkNITKIDNLslcKNLKVLYLYDNKITKIE---NLEFlTNLTHLYLQNNQIEKIEN---------LENLVNLK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 640 RLDLSLNRLKHIPNeafLNLPASLTELHINDnmlkffnwtllQQFPRlelldlrGNKLLFLTDSLSDFTSSLRTLLLSHN 719
Cdd:cd21340 72 KLYLGGNRISVVEG---LENLTNLEELHIEN-----------QRLPP-------GEKLTFDPRSLAALSNSLRVLNISGN 130
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2491161119 720 RISHLpsGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPF 771
Cdd:cd21340 131 NIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
60-439 |
1.15e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.04 E-value: 1.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 60 KYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITD--GAFLNLKNLRELLLEDNQLPQI 137
Cdd:COG4886 72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDlpEELANLTNLKELDLSNNQLTDL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 138 PSGLPE--SLTELSLIQNNIYNITKEgISRLINLKNLYLAWNcyfnkvcektNIEDgVFETLTNlellslsfnslshvpp 215
Cdd:COG4886 152 PEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNN----------QITD-LPEPLGN---------------- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 216 klPSSLRKLFLSNTQIKYISEEdFKGLINLTLLDLSGNcprcfnapfpcvpcdggasiNIDRF-AFQNLTQLRYLNLSST 294
Cdd:COG4886 204 --LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--------------------QLTDLpELGNLTNLEELDLSNN 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 295 SLRKINAAwfKNMPHLKVLDLEFNYlvgeiasgafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGY 374
Cdd:COG4886 261 QLTDLPPL--ANLTNLKTLDLSNNQ----------LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2491161119 375 VFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYA 439
Cdd:COG4886 329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
280-769 |
3.63e-11 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 67.57 E-value: 3.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 280 FQNLTQLRYLNLSSTSLRKINAAWFknMPHLKVLDLEFNYLVGEIAS--GAFltmlPRLEILDLSFNYIKGSYPQHI-NI 356
Cdd:PLN00113 114 FTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNdiGSF----SSLKVLDLGGNVLVGKIPNSLtNL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 357 SRnfSKLLSLRALHLRGYVFQELReddfqplmQLPNLSTINLGINFIK-QIDFKL-----------------------FQ 412
Cdd:PLN00113 188 TS--LEFLTLASNQLVGQIPRELG--------QMKSLKWIYLGYNNLSgEIPYEIggltslnhldlvynnltgpipssLG 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 413 NFSNLEIIYLSENRISPLVkdtrqsyansssfqrhirkrrstdfefdPHSNFYhfTRPLIkpqcaaygkALDLSLNSIFF 492
Cdd:PLN00113 258 NLKNLQYLFLYQNKLSGPI----------------------------PPSIFS--LQKLI---------SLDLSDNSLSG 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 493 IGPNQFENLPDIACLNLSANSnaqvLSGT---EFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAg 569
Cdd:PLN00113 299 EIPELVIQLQNLEILHLFSNN----FTGKipvALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIP- 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 570 vthhlEFIQNFTNLKVLNLSHNNI-----YTLTDKYNLESKSLVELVFSG------------NRLDILWNDDDNRYISIF 632
Cdd:PLN00113 374 -----EGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRLQDNSFSGelpseftklplvYFLDISNNNLQGRINSRK 448
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 633 KGLKNLTRLDLSLNRLkhipneaFLNLPAS-----LTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKllfLTDSLSDF 707
Cdd:PLN00113 449 WDMPSLQMLSLARNKF-------FGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK---LSGEIPDE 518
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2491161119 708 TSSLRTLL---LSHNRIS-HLPSGFlSEVSSLKHLDLSSNLLK---TINKSALETKTTTKLSMLELHGN 769
Cdd:PLN00113 519 LSSCKKLVsldLSHNQLSgQIPASF-SEMPVLSQLDLSQNQLSgeiPKNLGNVESLVQVNISHNHLHGS 586
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
877-1021 |
4.39e-11 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 62.38 E-value: 4.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 877 YDAYISYDTKDasVTDWVINELRYHLeesRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKS-WN--- 952
Cdd:pfam01582 1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 953 FKTAFYLALQRLMdenmdVIIFILLEPVLQHSQYL---------RLRQRICKSSILQWP------------DNPKAEGLF 1011
Cdd:pfam01582 76 LVKILECALDLGQ-----KVIPIFYEVDPSDVRKQtgsfgkafkKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKF 150
|
170
....*....|
gi 2491161119 1012 WQTLRNVVLT 1021
Cdd:pfam01582 151 WKKIAYDISN 160
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
637-697 |
2.44e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.07 E-value: 2.44e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2491161119 637 NLTRLDLSLNRLKHIPNEAFLNLPaSLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL 697
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
62-594 |
8.31e-09 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 59.86 E-value: 8.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 62 VTELDLSDNFITHITNESFQGLQNLTKINLNHNpnvqhqngnpgiQSNGlNITDGAFLNLKNLRELLLEDNQLP-QIPSG 140
Cdd:PLN00113 71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNN------------QLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 141 LPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKV-CEKTNIEDGVFETLTNLELLSlsfnslsHVPPKLPS 219
Cdd:PLN00113 138 SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIpNSLTNLTSLEFLTLASNQLVG-------QIPRELGQ 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 220 --SLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNcprcfNAPFPCVPCDGGASINIDRFAFQN------------LTQ 285
Cdd:PLN00113 211 mkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN-----NLTGPIPSSLGNLKNLQYLFLYQNklsgpippsifsLQK 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 286 LRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSkLLS 365
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA--LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLT-VLD 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 366 LRALHLRGYV---------------FQELREDDFQP-LMQLPNLSTINLGINfikQIDFKLFQNFSNLEIIY---LSENR 426
Cdd:PLN00113 363 LSTNNLTGEIpeglcssgnlfklilFSNSLEGEIPKsLGACRSLRRVRLQDN---SFSGELPSEFTKLPLVYfldISNNN 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 427 ISPLVKDTRQsyaNSSSFQRHIRKRRStdfefdphsnfyhFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIAC 506
Cdd:PLN00113 440 LQGRINSRKW---DMPSLQMLSLARNK-------------FFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQ 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 507 LNLSANSnaqvLSG---TEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNshyfRIAGvthhlEFIQNFTNL 583
Cdd:PLN00113 504 LKLSENK----LSGeipDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN----QLSG-----EIPKNLGNV 570
|
570
....*....|....
gi 2491161119 584 KVL---NLSHNNIY 594
Cdd:PLN00113 571 ESLvqvNISHNHLH 584
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
109-318 |
1.48e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 53.25 E-value: 1.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 109 NGLNITD-GAFLNLKNLRELLLEDNQLPQIP--SGLPeSLTELSLiQNNiyNITK-EGISRLINLKNLYLAWNCyfnkvc 184
Cdd:cd21340 10 NDKNITKiDNLSLCKNLKVLYLYDNKITKIEnlEFLT-NLTHLYL-QNN--QIEKiENLENLVNLKKLYLGGNR------ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 185 ektnIEdgVFETLTNlellslsfnslshvppklPSSLRKLFLSNTQ-------------IKYISEedfkgliNLTLLDLS 251
Cdd:cd21340 80 ----IS--VVEGLEN------------------LTNLEELHIENQRlppgekltfdprsLAALSN-------SLRVLNIS 128
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 252 GNcprcfnapfpcvpcdggasiNIDRFA-FQNLTQLRYLNLSSTSLRKIN--AAWFKNMPHLKVLDLEFN 318
Cdd:cd21340 129 GN--------------------NIDSLEpLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
284-346 |
1.60e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.06 E-value: 1.60e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2491161119 284 TQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGeIASGAFLTmLPRLEILDLSFNYI 346
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSG-LPSLRYLDLSGNRL 61
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
739-826 |
1.29e-06 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 52.78 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 739 DLSSNLLKTINKSALETKTTtkLSMLELHGNPFECTCDIGDFRRWMDEHlNVKIPRLVDVICASPGDQRGKSIVSLELTT 818
Cdd:TIGR00864 1 DISNNKISTIEEGICANLCN--LSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77
|
....*...
gi 2491161119 819 CVSDVTAV 826
Cdd:TIGR00864 78 SGCDEEYV 85
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
769-814 |
5.76e-06 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 44.34 E-value: 5.76e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 2491161119 769 NPFECTCDIGDFRRWMDEhlNVKIPRLVDVICASPGDQRGKSIVSL 814
Cdd:smart00082 1 NPFICDCELRWLLRWLQA--NEHLQDPVDLRCASPSSLRGPLLELL 44
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
462-772 |
3.04e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 97.70 E-value: 3.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 462 SNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDF 541
Cdd:COG4886 3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 542 DN----ASALTELSDLEVLDLSYNshyfriagvthhlEFIQNFTNLKVLNLSHNNIYTLTDK-YNLesKSLVELVFSGNR 616
Cdd:COG4886 83 SLlllgLTDLGDLTNLTELDLSGN-------------EELSNLTNLESLDLSGNQLTDLPEElANL--TNLKELDLSNNQ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 617 LDILWNDddnryisiFKGLKNLTRLDLSLNRLKHIPNEaFLNLPaSLTELHINDNMLKFFNWTlLQQFPRLELLDLRGNK 696
Cdd:COG4886 148 LTDLPEP--------LGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQ 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2491161119 697 LLFLTDSLSDFTsSLRTLLLSHNRISHLPSgfLSEVSSLKHLDLSSNLLKTINKSAletkTTTKLSMLELHGNPFE 772
Cdd:COG4886 217 LTDLPEPLANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA----NLTNLKTLDLSNNQLT 285
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
877-1019 |
2.42e-16 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 76.59 E-value: 2.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 877 YDAYISYdtkdaSVTDWVINELRYHLEESRDKNVLlCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTA 956
Cdd:smart00255 2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2491161119 957 FYLALQRLMDENMDVIIFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEglFWQTLRNVV 1019
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWKKALYAV 137
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
481-769 |
9.98e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 74.58 E-value: 9.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 481 KALDLSLNSIFFIgPNQFENLPDIACLNLSANSNAQVlsGTEFSAIPHVKYLDLTNNRLDfDNASALTELSDLEVLDLSY 560
Cdd:COG4886 116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL--PEPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSN 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 561 NshyfRIAGVTHHLEfiqNFTNLKVLNLSHNNIYTLTDKYNlESKSLVELVFSGNRLdilwndddnRYISIFKGLKNLTR 640
Cdd:COG4886 192 N----QITDLPEPLG---NLTNLEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQL---------TDLPELGNLTNLEE 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 641 LDLSLNRLKHIPNEAFLnlpASLTELHINDNMLKFFNWTLLQ--QFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSH 718
Cdd:COG4886 255 LDLSNNQLTDLPPLANL---TNLKTLDLSNNQLTDLKLKELEllLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2491161119 719 NRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGN 769
Cdd:COG4886 332 GLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
570-771 |
3.75e-13 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 69.81 E-value: 3.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 570 VTH------HLEFIQNF---TNLKVLNLSHNNIYTLTdkyNLES-KSLVELVFSGNRLDILWNdddnryisiFKGLKNLT 639
Cdd:cd21340 4 ITHlylndkNITKIDNLslcKNLKVLYLYDNKITKIE---NLEFlTNLTHLYLQNNQIEKIEN---------LENLVNLK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 640 RLDLSLNRLKHIPNeafLNLPASLTELHINDnmlkffnwtllQQFPRlelldlrGNKLLFLTDSLSDFTSSLRTLLLSHN 719
Cdd:cd21340 72 KLYLGGNRISVVEG---LENLTNLEELHIEN-----------QRLPP-------GEKLTFDPRSLAALSNSLRVLNISGN 130
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2491161119 720 RISHLpsGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPF 771
Cdd:cd21340 131 NIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
60-439 |
1.15e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.04 E-value: 1.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 60 KYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITD--GAFLNLKNLRELLLEDNQLPQI 137
Cdd:COG4886 72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDlpEELANLTNLKELDLSNNQLTDL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 138 PSGLPE--SLTELSLIQNNIYNITKEgISRLINLKNLYLAWNcyfnkvcektNIEDgVFETLTNlellslsfnslshvpp 215
Cdd:COG4886 152 PEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNN----------QITD-LPEPLGN---------------- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 216 klPSSLRKLFLSNTQIKYISEEdFKGLINLTLLDLSGNcprcfnapfpcvpcdggasiNIDRF-AFQNLTQLRYLNLSST 294
Cdd:COG4886 204 --LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--------------------QLTDLpELGNLTNLEELDLSNN 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 295 SLRKINAAwfKNMPHLKVLDLEFNYlvgeiasgafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGY 374
Cdd:COG4886 261 QLTDLPPL--ANLTNLKTLDLSNNQ----------LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2491161119 375 VFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYA 439
Cdd:COG4886 329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
481-766 |
1.49e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 67.65 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 481 KALDLSLNSIFFIgPNQFENLPDIACLNLSANSNAQVlsGTEFSAIPHVKYLDLTNNRLDfDNASALTELSDLEVLDLSY 560
Cdd:COG4886 139 KELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL--PEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSG 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 561 NshyfriaGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLesKSLVELVFSGNRLdilwndddnRYISIFKGLKNLTR 640
Cdd:COG4886 215 N-------QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNL--TNLEELDLSNNQL---------TDLPPLANLTNLKT 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 641 LDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNR 720
Cdd:COG4886 277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2491161119 721 ISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLEL 766
Cdd:COG4886 357 NLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
101-430 |
1.63e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 67.65 E-value: 1.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 101 NGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYF 180
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 181 NKVCEKTNIEDgvFETLTNLELLSLSFNSlshvPPKLPSSLRKLFLSNTQIKYISEEdFKGLINLTLLDLSGNcprcfna 260
Cdd:COG4886 81 LLSLLLLGLTD--LGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNN------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 261 pfpcvpcdggaSINIDRFAFQNLTQLRYLNLSSTSLRKINaAWFKNMPHLKVLDLEFNYLvGEIasGAFLTMLPRLEILD 340
Cdd:COG4886 147 -----------QLTDLPEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQI-TDL--PEPLGNLTNLEELD 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 341 LSFNYIKgsypqhiNISRNFSKLLSLRALHLRGYVFQELREddfqpLMQLPNLSTINLGINFIKQIDFklFQNFSNLEII 420
Cdd:COG4886 212 LSGNQLT-------DLPEPLANLTNLETLDLSNNQLTDLPE-----LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTL 277
|
330
....*....|
gi 2491161119 421 YLSENRISPL 430
Cdd:COG4886 278 DLSNNQLTDL 287
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
82-538 |
3.10e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 66.88 E-value: 3.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 82 GLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQlpqiPSGLPESLTELSLIQNNIYNITKE 161
Cdd:COG4886 56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPEE 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 162 gISRLINLKNLYLAWNcyfnkvcektNIEDgvfetltnlellslsfnslshVPPKLPS--SLRKLFLSNTQIKYISEEdF 239
Cdd:COG4886 132 -LANLTNLKELDLSNN----------QLTD---------------------LPEPLGNltNLKSLDLSNNQLTDLPEE-L 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 240 KGLINLTLLDLSGNcprcfnapfpcvpcdggasiNIDRF--AFQNLTQLRYLNLSSTSLRKINAAwFKNMPHLKVLDLEF 317
Cdd:COG4886 179 GNLTNLKELDLSNN--------------------QITDLpePLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 318 NylvgEIASGAFLTMLPRLEILDLSFNYIKgsypqhinisrnfskllslralhlrgyvfqelredDFQPLMQLPNLSTIN 397
Cdd:COG4886 238 N----QLTDLPELGNLTNLEELDLSNNQLT-----------------------------------DLPPLANLTNLKTLD 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 398 LGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYhftrpLIKPQCA 477
Cdd:COG4886 279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL-----LALLTLL 353
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2491161119 478 AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNR 538
Cdd:COG4886 354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
280-769 |
3.63e-11 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 67.57 E-value: 3.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 280 FQNLTQLRYLNLSSTSLRKINAAWFknMPHLKVLDLEFNYLVGEIAS--GAFltmlPRLEILDLSFNYIKGSYPQHI-NI 356
Cdd:PLN00113 114 FTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNdiGSF----SSLKVLDLGGNVLVGKIPNSLtNL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 357 SRnfSKLLSLRALHLRGYVFQELReddfqplmQLPNLSTINLGINFIK-QIDFKL-----------------------FQ 412
Cdd:PLN00113 188 TS--LEFLTLASNQLVGQIPRELG--------QMKSLKWIYLGYNNLSgEIPYEIggltslnhldlvynnltgpipssLG 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 413 NFSNLEIIYLSENRISPLVkdtrqsyansssfqrhirkrrstdfefdPHSNFYhfTRPLIkpqcaaygkALDLSLNSIFF 492
Cdd:PLN00113 258 NLKNLQYLFLYQNKLSGPI----------------------------PPSIFS--LQKLI---------SLDLSDNSLSG 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 493 IGPNQFENLPDIACLNLSANSnaqvLSGT---EFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAg 569
Cdd:PLN00113 299 EIPELVIQLQNLEILHLFSNN----FTGKipvALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIP- 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 570 vthhlEFIQNFTNLKVLNLSHNNI-----YTLTDKYNLESKSLVELVFSG------------NRLDILWNDDDNRYISIF 632
Cdd:PLN00113 374 -----EGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRLQDNSFSGelpseftklplvYFLDISNNNLQGRINSRK 448
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 633 KGLKNLTRLDLSLNRLkhipneaFLNLPAS-----LTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKllfLTDSLSDF 707
Cdd:PLN00113 449 WDMPSLQMLSLARNKF-------FGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK---LSGEIPDE 518
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2491161119 708 TSSLRTLL---LSHNRIS-HLPSGFlSEVSSLKHLDLSSNLLK---TINKSALETKTTTKLSMLELHGN 769
Cdd:PLN00113 519 LSSCKKLVsldLSHNQLSgQIPASF-SEMPVLSQLDLSQNQLSgeiPKNLGNVESLVQVNISHNHLHGS 586
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
877-1021 |
4.39e-11 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 62.38 E-value: 4.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 877 YDAYISYDTKDasVTDWVINELRYHLeesRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKS-WN--- 952
Cdd:pfam01582 1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 953 FKTAFYLALQRLMdenmdVIIFILLEPVLQHSQYL---------RLRQRICKSSILQWP------------DNPKAEGLF 1011
Cdd:pfam01582 76 LVKILECALDLGQ-----KVIPIFYEVDPSDVRKQtgsfgkafkKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKF 150
|
170
....*....|
gi 2491161119 1012 WQTLRNVVLT 1021
Cdd:pfam01582 151 WKKIAYDISN 160
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
47-253 |
5.84e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 65.73 E-value: 5.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 47 SNRRLQEVPQTVG--KYVTELDLSDNFITHItNESFQGLQNLTKINLNHNpnvqhqngnpgiqsnglNITD--GAFLNLK 122
Cdd:COG4886 121 SGNQLTDLPEELAnlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN-----------------QLTDlpEELGNLT 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 123 NLRELLLEDNQLPQIPSGL--PESLTELSLIQNNIYNITKEgISRLINLKNLYLAWNcyfnkvcektNIEDgvFETLTNL 200
Cdd:COG4886 183 NLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----------QLTD--LPELGNL 249
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2491161119 201 ellslsfnslshvppklpSSLRKLFLSNTQIKYISEEdfKGLINLTLLDLSGN 253
Cdd:COG4886 250 ------------------TNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNN 282
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
306-771 |
4.14e-10 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 64.10 E-value: 4.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 306 NMPHLKVLDLEFNYLVGEIASGAFltMLPRLEILDLSFNYIKGSYPQHInisrnFSKLLSLRALHLRGYVFQelredDFQ 385
Cdd:PLN00113 67 NSSRVVSIDLSGKNISGKISSAIF--RLPYIQTINLSNNQLSGPIPDDI-----FTTSSSLRYLNLSNNNFT-----GSI 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 386 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENrisPLVKDTRQSYANSSSFQ--------------RHIRKR 451
Cdd:PLN00113 135 PRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN---VLVGKIPNSLTNLTSLEfltlasnqlvgqipRELGQM 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 452 RSTDFEFDPHSNFYHFTrPLIKPQCAAYGKaLDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSaIPHVKY 531
Cdd:PLN00113 212 KSLKWIYLGYNNLSGEI-PYEIGGLTSLNH-LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS-LQKLIS 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 532 LDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQ-------NFT-----------NLKVLNLSHNNI 593
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQvlqlwsnKFSgeipknlgkhnNLTVLDLSTNNL 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 594 YTLTDKYNLESKSLVELVFSGNRLDilwndddnryISIFKGL---KNLTRLDLSLNRLKHIPNEAFLNLPAsLTELHIND 670
Cdd:PLN00113 369 TGEIPEGLCSSGNLFKLILFSNSLE----------GEIPKSLgacRSLRRVRLQDNSFSGELPSEFTKLPL-VYFLDISN 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 671 NMLKFFNWTLLQQFPRLELLDLRGNKLLfltDSLSDFTSS--LRTLLLSHNRISH-LPSGFLSeVSSLKHLDLSSNLLKT 747
Cdd:PLN00113 438 NNLQGRINSRKWDMPSLQMLSLARNKFF---GGLPDSFGSkrLENLDLSRNQFSGaVPRKLGS-LSELMQLKLSENKLSG 513
|
490 500
....*....|....*....|....
gi 2491161119 748 INKSalETKTTTKLSMLELHGNPF 771
Cdd:PLN00113 514 EIPD--ELSSCKKLVSLDLSHNQL 535
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
880-991 |
1.35e-09 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 56.94 E-value: 1.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 880 YISYDTKDASVTDWVINELryhleESRDKNVLLclEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYL 959
Cdd:pfam13676 2 FISYAGEDRAWAEWLADAL-----EAAGYRVWL--DRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74
|
90 100 110
....*....|....*....|....*....|....*..
gi 2491161119 960 ALQRLMDENmdVIIFILLE-----PVLQHSQYLRLRQ 991
Cdd:pfam13676 75 ALADPEGRK--RLIPVRLEcdlelPGLAGLQYIDLRD 109
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
637-697 |
2.44e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.07 E-value: 2.44e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2491161119 637 NLTRLDLSLNRLKHIPNEAFLNLPaSLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL 697
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
62-594 |
8.31e-09 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 59.86 E-value: 8.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 62 VTELDLSDNFITHITNESFQGLQNLTKINLNHNpnvqhqngnpgiQSNGlNITDGAFLNLKNLRELLLEDNQLP-QIPSG 140
Cdd:PLN00113 71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNN------------QLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 141 LPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKV-CEKTNIEDGVFETLTNLELLSlsfnslsHVPPKLPS 219
Cdd:PLN00113 138 SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIpNSLTNLTSLEFLTLASNQLVG-------QIPRELGQ 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 220 --SLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNcprcfNAPFPCVPCDGGASINIDRFAFQN------------LTQ 285
Cdd:PLN00113 211 mkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN-----NLTGPIPSSLGNLKNLQYLFLYQNklsgpippsifsLQK 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 286 LRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSkLLS 365
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA--LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLT-VLD 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 366 LRALHLRGYV---------------FQELREDDFQP-LMQLPNLSTINLGINfikQIDFKLFQNFSNLEIIY---LSENR 426
Cdd:PLN00113 363 LSTNNLTGEIpeglcssgnlfklilFSNSLEGEIPKsLGACRSLRRVRLQDN---SFSGELPSEFTKLPLVYfldISNNN 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 427 ISPLVKDTRQsyaNSSSFQRHIRKRRStdfefdphsnfyhFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIAC 506
Cdd:PLN00113 440 LQGRINSRKW---DMPSLQMLSLARNK-------------FFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQ 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 507 LNLSANSnaqvLSG---TEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNshyfRIAGvthhlEFIQNFTNL 583
Cdd:PLN00113 504 LKLSENK----LSGeipDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN----QLSG-----EIPKNLGNV 570
|
570
....*....|....
gi 2491161119 584 KVL---NLSHNNIY 594
Cdd:PLN00113 571 ESLvqvNISHNHLH 584
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
213-719 |
2.00e-08 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.64 E-value: 2.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 213 VPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLS 292
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 293 STSLRKINAAWFKNMPHLKVLDLEFNylvgeiasgAFLTMLPRLEILDLSFNYIKgsypqhiNISRNFSKLLSLRALHLR 372
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLT-------DLPEELANLTNLKELDLS 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 373 GYVFQELREddfqPLMQLPNLSTINLGINFIKQIDfKLFQNFSNLEIIYLSENRISPLvkdtrqsyansssfqrhirkrr 452
Cdd:COG4886 145 NNQLTDLPE----PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL---------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 453 stdfefdphsnfyhftrplikpqcaaygkaldlslnsiffigPNQFENLPDIACLNLSANSNAQVlsGTEFSAIPHVKYL 532
Cdd:COG4886 198 ------------------------------------------PEPLGNLTNLEELDLSGNQLTDL--PEPLANLTNLETL 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 533 DLTNNRLDfdNASALTELSDLEVLDLSYNshyfRIAgvthHLEFIQNFTNLKVLNLSHNNIYTLtdkyNLESKSLVELVF 612
Cdd:COG4886 234 DLSNNQLT--DLPELGNLTNLEELDLSNN----QLT----DLPPLANLTNLKTLDLSNNQLTDL----KLKELELLLGLN 299
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 613 SGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDL 692
Cdd:COG4886 300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATL 379
|
490 500
....*....|....*....|....*..
gi 2491161119 693 RGNKLLFLTDSLSDFTSSLRTLLLSHN 719
Cdd:COG4886 380 LTLALLLLTLLLLLLTTTAGVLLLTLA 406
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
483-698 |
2.47e-08 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 56.98 E-value: 2.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 483 LDLSLNSIFFIGPNQFENLPDIACL-NLSANSNAQVLSGTEFSA------IPHVKYLDLTNNRLD----FDNASALTELS 551
Cdd:cd00116 86 LDLSDNALGPDGCGVLESLLRSSSLqELKLNNNGLGDRGLRLLAkglkdlPPALEKLVLGRNRLEgascEALAKALRANR 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 552 DLEVLDLSYNShyFRIAGVTHHLEFIQNFTNLKVLNLSHNniyTLTDKynlESKSLVElvfsgnrldilwndddnryisI 631
Cdd:cd00116 166 DLKELNLANNG--IGDAGIRALAEGLKANCNLEVLDLNNN---GLTDE---GASALAE---------------------T 216
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2491161119 632 FKGLKNLTRLDLSLNRLKHIP----NEAFLNLPASLTELHINDNMLKFFNW----TLLQQFPRLELLDLRGNKLL 698
Cdd:cd00116 217 LASLKSLEVLNLGDNNLTDAGaaalASALLSPNISLLTLSLSCNDITDDGAkdlaEVLAEKESLLELDLRGNKFG 291
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
217-673 |
8.67e-08 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 56.39 E-value: 8.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 217 LPSSLRKLFLSNTqikyiseeDFKGLI------NLTLLDLSGN-----CPRCFNAPFPCVPCDGGASINIDRF--AFQNL 283
Cdd:PLN00113 116 TSSSLRYLNLSNN--------NFTGSIprgsipNLETLDLSNNmlsgeIPNDIGSFSSLKVLDLGGNVLVGKIpnSLTNL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 284 TQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGafLTMLPRLEILDLSFNYIKGSYPQHINisrNFSKL 363
Cdd:PLN00113 188 TSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYE--IGGLTSLNHLDLVYNNLTGPIPSSLG---NLKNL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 364 LSLralhlrgYVFQELREDDFQP-LMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYAN-- 440
Cdd:PLN00113 263 QYL-------FLYQNKLSGPIPPsIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRlq 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 441 -----SSSFQRHIRKrrstdfEFDPHSNFyhftrplikpqcaaygKALDLSLNS------------------IFFIGPNQ 497
Cdd:PLN00113 336 vlqlwSNKFSGEIPK------NLGKHNNL----------------TVLDLSTNNltgeipeglcssgnlfklILFSNSLE 393
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 498 FENLPDI-AC-----LNLSANSNAQVLSgTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFriagvt 571
Cdd:PLN00113 394 GEIPKSLgACrslrrVRLQDNSFSGELP-SEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFG------ 466
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 572 hhlEFIQNF--TNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDdnryisiFKGLKNLTRLDLSLNRLK 649
Cdd:PLN00113 467 ---GLPDSFgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDE-------LSSCKKLVSLDLSHNQLS 536
|
490 500
....*....|....*....|....*
gi 2491161119 650 -HIPnEAFLNLPAsLTELHINDNML 673
Cdd:PLN00113 537 gQIP-ASFSEMPV-LSQLDLSQNQL 559
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
109-318 |
1.48e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 53.25 E-value: 1.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 109 NGLNITD-GAFLNLKNLRELLLEDNQLPQIP--SGLPeSLTELSLiQNNiyNITK-EGISRLINLKNLYLAWNCyfnkvc 184
Cdd:cd21340 10 NDKNITKiDNLSLCKNLKVLYLYDNKITKIEnlEFLT-NLTHLYL-QNN--QIEKiENLENLVNLKKLYLGGNR------ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 185 ektnIEdgVFETLTNlellslsfnslshvppklPSSLRKLFLSNTQ-------------IKYISEedfkgliNLTLLDLS 251
Cdd:cd21340 80 ----IS--VVEGLEN------------------LTNLEELHIENQRlppgekltfdprsLAALSN-------SLRVLNIS 128
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 252 GNcprcfnapfpcvpcdggasiNIDRFA-FQNLTQLRYLNLSSTSLRKIN--AAWFKNMPHLKVLDLEFN 318
Cdd:cd21340 129 GN--------------------NIDSLEpLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
284-346 |
1.60e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.06 E-value: 1.60e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2491161119 284 TQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGeIASGAFLTmLPRLEILDLSFNYI 346
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSG-LPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
709-771 |
2.08e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.67 E-value: 2.08e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2491161119 709 SSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALEtkTTTKLSMLELHGNPF 771
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS--GLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
685-745 |
2.77e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.29 E-value: 2.77e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2491161119 685 PRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLL 745
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
509-745 |
2.77e-07 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 54.70 E-value: 2.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 509 LSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHyfriaGVTHHLEFIQNftNLKVLNL 588
Cdd:PRK15370 176 LKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSN-----QLTSIPATLPD--TIQEMEL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 589 SHNNIYTLTDKynLESkSLVELVFSGNRLDILWND--DDNRYISIFKglknltrldlslNRLKHIPNeaflNLPASLTEL 666
Cdd:PRK15370 249 SINRITELPER--LPS-ALQSLDLFHNKISCLPENlpEELRYLSVYD------------NSIRTLPA----HLPSGITHL 309
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2491161119 667 HINDNMLKFFNWTLLqqfPRLELLDLRGNKLLFLTDSLSdftSSLRTLLLSHNRISHLPSGFlseVSSLKHLDLSSNLL 745
Cdd:PRK15370 310 NVQSNSLTALPETLP---PGLKTLEAGENALTSLPASLP---PELQVLDVSKNQITVLPETL---PPTITTLDVSRNAL 379
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
62-134 |
3.30e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.29 E-value: 3.30e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2491161119 62 VTELDLSDNFITHITNESFQGLQNLTKINLNHNpnvqhqngnpgiqsNGLNITDGAFLNLKNLRELLLEDNQL 134
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN--------------LLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
502-747 |
9.08e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.97 E-value: 9.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 502 PDIACLNLSANSNAQVLSGTE-----FSAIPHVKYLDLTNNRLDFDNA---SALTELSDLEVLDLSYNSH-----YFRIA 568
Cdd:cd00116 51 PSLKELCLSLNETGRIPRGLQsllqgLTKGCGLQELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLgdrglRLLAK 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 569 GVTHHLEfiqnftNLKVLNLSHNNIY--TLTDKYNLESK--SLVELVFSGNRLdilwNDDDNRYIS-IFKGLKNLTRLDL 643
Cdd:cd00116 131 GLKDLPP------ALEKLVLGRNRLEgaSCEALAKALRAnrDLKELNLANNGI----GDAGIRALAeGLKANCNLEVLDL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 644 SLNRLKHIPNEAF---LNLPASLTELHINDNmlkffnwtllqqfprleLLDLRGnkLLFLTDSLSDFTSSLRTLLLSHNR 720
Cdd:cd00116 201 NNNGLTDEGASALaetLASLKSLEVLNLGDN-----------------NLTDAG--AAALASALLSPNISLLTLSLSCND 261
|
250 260 270
....*....|....*....|....*....|.
gi 2491161119 721 ISHLPSGFLSEV----SSLKHLDLSSNLLKT 747
Cdd:cd00116 262 ITDDGAKDLAEVlaekESLLELDLRGNKFGE 292
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
739-826 |
1.29e-06 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 52.78 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 739 DLSSNLLKTINKSALETKTTtkLSMLELHGNPFECTCDIGDFRRWMDEHlNVKIPRLVDVICASPGDQRGKSIVSLELTT 818
Cdd:TIGR00864 1 DISNNKISTIEEGICANLCN--LSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77
|
....*...
gi 2491161119 819 CVSDVTAV 826
Cdd:TIGR00864 78 SGCDEEYV 85
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
508-721 |
1.67e-06 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 51.71 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 508 NLSANSNAQVLSGTefsaiPHVKYLDLTNNRLDFDNASALTEL----SDLEVLDLSYNshYFRIAGVTHHLEFIQNFTNL 583
Cdd:COG5238 222 DEGAEILAEALKGN-----KSLTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGN--QIGAEGAIALAKALQGNTTL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 584 KVLNLSHNNIytlTDK------YNLE-SKSLVELVFSGNRLDilwnddDNRYISIFKGLK---NLTRLDLSLNRLKHIPN 653
Cdd:COG5238 295 TSLDLSVNRI---GDEgaialaEGLQgNKTLHTLNLAYNGIG------AQGAIALAKALQentTLHSLDLSDNQIGDEGA 365
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2491161119 654 EAFLNLPASLTELHindnmlkffnwtllqqfprleLLDLRGNKL-----LFLTDSLSdfTSSLRTLLLSHNRI 721
Cdd:COG5238 366 IALAKYLEGNTTLR---------------------ELNLGKNNIgkqgaEALIDALQ--TNRLHTLILDGNLI 415
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
274-320 |
2.21e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.98 E-value: 2.21e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 2491161119 274 NIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYL 320
Cdd:pfam13855 15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
526-743 |
2.96e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 50.43 E-value: 2.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 526 IPHVKYLDLTNNRLDFDNASALTEL----SDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTD--- 598
Cdd:cd00116 22 LLCLQVLRLEGNTLGEEAAKALASAlrpqPSLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCgvl 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 599 KYNLESKSLVELVFSGNRLDilwnDDDNRYISifKGLK----NLTRLDLSLNRLKHIPNEAFLN-LPA--SLTELHINDN 671
Cdd:cd00116 102 ESLLRSSSLQELKLNNNGLG----DRGLRLLA--KGLKdlppALEKLVLGRNRLEGASCEALAKaLRAnrDLKELNLANN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 672 MLKFFNWTLLQQ----FPRLELLDLRGNKL-----LFLTDSLSDfTSSLRTLLLSHNRI-----SHLPSGFLSEVSSLKH 737
Cdd:cd00116 176 GIGDAGIRALAEglkaNCNLEVLDLNNNGLtdegaSALAETLAS-LKSLEVLNLGDNNLtdagaAALASALLSPNISLLT 254
|
....*.
gi 2491161119 738 LDLSSN 743
Cdd:cd00116 255 LSLSCN 260
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
636-748 |
3.07e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 51.24 E-value: 3.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 636 KNLTRLDLSLNRLKHIPNeaflNLPASLTELHINDNMLKFFNWTLLQQfprLELLDLRGNKLLFLTDSLSdftSSLRTLL 715
Cdd:PRK15370 199 EQITTLILDNNELKSLPE----NLQGNIKTLYANSNQLTSIPATLPDT---IQEMELSINRITELPERLP---SALQSLD 268
|
90 100 110
....*....|....*....|....*....|...
gi 2491161119 716 LSHNRISHLPSGFLSEvssLKHLDLSSNLLKTI 748
Cdd:PRK15370 269 LFHNKISCLPENLPEE---LRYLSVYDNSIRTL 298
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
769-814 |
5.76e-06 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 44.34 E-value: 5.76e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 2491161119 769 NPFECTCDIGDFRRWMDEhlNVKIPRLVDVICASPGDQRGKSIVSL 814
Cdd:smart00082 1 NPFICDCELRWLLRWLQA--NEHLQDPVDLRCASPSSLRGPLLELL 44
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
581-673 |
6.02e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.44 E-value: 6.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 581 TNLKVLNLSHNNIYTLTDkynleskslvelvfsgnrldilwndddnryiSIFKGLKNLTRLDLSLNRLKHIPNEAFLNLP 660
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDD-------------------------------GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP 49
|
90
....*....|...
gi 2491161119 661 aSLTELHINDNML 673
Cdd:pfam13855 50 -SLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
63-178 |
3.44e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 46.32 E-value: 3.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 63 TELDLSDNFITHITNesFQGLQNLTKINLNHNPnvqhqngnpgIQS-NGLNitdgaflNLKNLRELLLEDNQL------- 134
Cdd:cd21340 49 THLYLQNNQIEKIEN--LENLVNLKKLYLGGNR----------ISVvEGLE-------NLTNLEELHIENQRLppgeklt 109
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 2491161119 135 --PQIPSGLPESLTELSLIQNNIYNItkEGISRLINLKNLYLAWNC 178
Cdd:cd21340 110 fdPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQ 153
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
527-593 |
3.60e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.51 E-value: 3.60e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2491161119 527 PHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNShyfriagvthhLEFI-----QNFTNLKVLNLSHNNI 593
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL-----------LTTLspgafSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
219-296 |
8.79e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.36 E-value: 8.79e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2491161119 219 SSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCfnapfpcvpcdggasinIDRFAFQNLTQLRYLNLSSTSL 296
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-----------------LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
558-770 |
2.55e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 44.27 E-value: 2.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 558 LSYNSHYFRIAGVTHHLEFIQNftnLKVLNLSHNNIYTLTDKY---NLESK-SLVELVFSGNRLDilwNDDDN--RYISI 631
Cdd:cd00116 3 LSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGEEAAKAlasALRPQpSLKELCLSLNETG---RIPRGlqSLLQG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 632 FKGLKNLTRLDLSLNRLKHIPNEAFLNL--PASLTELHINDNML-----KFFNWTLLQQFPRLELLDLRGNKL-LFLTDS 703
Cdd:cd00116 77 LTKGCGLQELDLSDNALGPDGCGVLESLlrSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLeGASCEA 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2491161119 704 LSD---FTSSLRTLLLSHNRISHlpSGF------LSEVSSLKHLDLSSNLLKTINKSALET--KTTTKLSMLELHGNP 770
Cdd:cd00116 157 LAKalrANRDLKELNLANNGIGD--AGIralaegLKANCNLEVLDLNNNGLTDEGASALAEtlASLKSLEVLNLGDNN 232
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
120-263 |
2.82e-04 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 45.07 E-value: 2.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 120 NLK-NLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLknlylawNCYFNKV-CEKTNIEDGVfETL 197
Cdd:PRK15370 217 NLQgNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSL-------DLFHNKIsCLPENLPEEL-RYL 288
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2491161119 198 TnlellsLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEedfKGLINLTLLDLSGNCPRCFNAPFP 263
Cdd:PRK15370 289 S------VYDNSIRTLPAHLPSGITHLNVQSNSLTALPE---TLPPGLKTLEAGENALTSLPASLP 345
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
516-754 |
3.25e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 44.40 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 516 QVLSGTEFSAIPHVKYLDLTNNRLDFDN----ASALTELSDLEVLDLSYNshYFRIAGVTHHLEFIQNFTNLKVLNLSHN 591
Cdd:COG5238 169 AAISMAKALQNNSVETVYLGCNQIGDEGieelAEALTQNTTVTTLWLKRN--PIGDEGAEILAEALKGNKSLTTLDLSNN 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 592 NIytlTD-------KYNLESKSLVELVFSGNRLdilwndDDNRYISIFKGL---KNLTRLDLSLNRlkhIPNEAFLNL-- 659
Cdd:COG5238 247 QI---GDegvialaEALKNNTTVETLYLSGNQI------GAEGAIALAKALqgnTTLTSLDLSVNR---IGDEGAIALae 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 660 ----PASLTELHINDNMLKFFNWTLL----QQFPRLELLDLRGNKL-----LFLTDSLSDFTsSLRTLLLSHNRIShlPS 726
Cdd:COG5238 315 glqgNKTLHTLNLAYNGIGAQGAIALakalQENTTLHSLDLSDNQIgdegaIALAKYLEGNT-TLRELNLGKNNIG--KQ 391
|
250 260 270
....*....|....*....|....*....|...
gi 2491161119 727 GFLSEVSSLKH-----LDLSSNLLKTINKSALE 754
Cdd:COG5238 392 GAEALIDALQTnrlhtLILDGNLIGAEAQQRLE 424
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
283-351 |
3.97e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 44.42 E-value: 3.97e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2491161119 283 LTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIAsgAFLTMLPRLEILDLSFNYIKGSYP 351
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP--ESLGQLTSLRILNLNGNSLSGRVP 507
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
308-373 |
4.11e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.43 E-value: 4.11e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2491161119 308 PHLKVLDLEFNYLVGeIASGAFLTmLPRLEILDLSFNYIKGSYPQHinisrnFSKLLSLRALHLRG 373
Cdd:pfam13855 1 PNLRSLDLSNNRLTS-LDDGAFKG-LSNLKVLDLSNNLLTTLSPGA------FSGLPSLRYLDLSG 58
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
483-539 |
5.21e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.04 E-value: 5.21e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 2491161119 483 LDLSLNSIFFIGPNQFENLPDIACLNLSaNSNAQVLSGTEFSAIPHVKYLDLTNNRL 539
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLS-NNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
507-561 |
5.64e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.04 E-value: 5.64e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 2491161119 507 LNLSANsNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 561
Cdd:pfam13855 6 LDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
263-373 |
6.25e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 43.65 E-value: 6.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 263 PCVPCD---GGASINIDRFAFQNLtqLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIaSGAFLTMlPRLEIL 339
Cdd:PLN03150 396 PCVPQQhpwSGADCQFDSTKGKWF--IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNI-PPSLGSI-TSLEVL 471
|
90 100 110
....*....|....*....|....*....|....
gi 2491161119 340 DLSFNYIKGSYPQHInisrnfSKLLSLRALHLRG 373
Cdd:PLN03150 472 DLSYNSFNGSIPESL------GQLTSLRILNLNG 499
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
583-653 |
1.79e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 1.79e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2491161119 583 LKVLNLSHNNIYTLTDKYNLesKSLVELVFSGNRLDilwndDDNRYISIFKGLKNLTRLDLSLNRLKHIPN 653
Cdd:cd21340 122 LRVLNISGNNIDSLEPLAPL--RNLEQLDASNNQIS-----DLEELLDLLSSWPSLRELDLTGNPVCKKPK 185
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
20-172 |
2.25e-03 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 41.99 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 20 ELCAEENFSRSYPcdEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLN------H 93
Cdd:PRK15370 224 TLYANSNQLTSIP--ATLPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSirtlpaH 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 94 NPN-VQHQNgnpgIQSNGLNITDGAFLnlKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIY--------NITKEGIS 164
Cdd:PRK15370 302 LPSgITHLN----VQSNSLTALPETLP--PGLKTLEAGENALTSLPASLPPELQVLDVSKNQITvlpetlppTITTLDVS 375
|
170
....*....|.
gi 2491161119 165 R--LINL-KNL 172
Cdd:PRK15370 376 RnaLTNLpENL 386
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
122-359 |
3.24e-03 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 41.61 E-value: 3.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 122 KNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNItKEGISRliNLKNLYLAWNcyfnkvcEKTNIEDGVFETLtnlE 201
Cdd:PRK15370 178 NNKTELRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQG--NIKTLYANSN-------QLTSIPATLPDTI---Q 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 202 LLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDlsgNCPRCFNAPFPcvpcdggasinidrfafq 281
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTLPAHLP------------------ 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491161119 282 nlTQLRYLNLSSTSLRKINAAWfknMPHLKVLDLEFNYLVGEIASgafltMLPRLEILDLSFNYIK---GSYP---QHIN 355
Cdd:PRK15370 304 --SGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPAS-----LPPELQVLDVSKNQITvlpETLPptiTTLD 373
|
....
gi 2491161119 356 ISRN 359
Cdd:PRK15370 374 VSRN 377
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
520-591 |
4.89e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 40.95 E-value: 4.89e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2491161119 520 GTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAgvthhlEFIQNFTNLKVLNLSHN 591
Cdd:PLN03150 435 PNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP------ESLGQLTSLRILNLNGN 500
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
391-428 |
9.89e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.58 E-value: 9.89e-03
10 20 30
....*....|....*....|....*....|....*...
gi 2491161119 391 PNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRIS 428
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT 38
|
|
| |
