mDax1-225 [Mus musculus]
Protein Classification
nuclear hormone receptor family protein( domain architecture ID 10623948)
nuclear hormone receptor family protein is a ligand-regulated transcriptional modulator that may play a role in many developmental processes; similar to Rattus norvegicus nuclear receptor subfamily 0 group B member 2
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| NR_LBD_Dax1 | cd07350 | The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain; The ... |
31-219 | 1.69e-116 | ||||
The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain; The ligand binding domain of the DAX1 protein: DAX1 (dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on chromosome X gene 1) is a nuclear receptor with a typical ligand binding domain, but lacks the DNA binding domain. DAX1 plays an important role in the normal development of several hormone-producing tissues. Duplications of the region of the X chromosome containing DAX1 cause dosage sensitive sex reversal. DAX1 acts as a global repressor of many nuclear receptors, including SF-1, LRH-1, ERR, ER, AR and PR. DAX1 can form homodimer and heterodimerizes with its alternatively spliced isoform DAX1A and other nuclear receptors such as SHP, ERalpha and SF-1. : Pssm-ID: 132764 Cd Length: 232 Bit Score: 331.79 E-value: 1.69e-116
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| NR_Repeat | pfam14046 | Nuclear receptor repeat; This is a repeat domain involved in dimerization of nuclear receptors ... |
1-48 | 5.46e-13 | ||||
Nuclear receptor repeat; This is a repeat domain involved in dimerization of nuclear receptors proteins and in transcriptional regulation in general. It contains a Leu-Xaa-Xaa-Leu-Leu motif which has been characterized for the orphan nuclear receptor Dax-1, which represses the constitutively expressed protein Ad4BP/SF-1. The LXXLL motif plays in important role in binding of Dax-1 to Ad4BP/SF-1. The domain is subject to structure determination by the Joint Center of Structural Genomics. : Pssm-ID: 464070 Cd Length: 47 Bit Score: 61.24 E-value: 5.46e-13
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| Name | Accession | Description | Interval | E-value | ||||
| NR_LBD_Dax1 | cd07350 | The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain; The ... |
31-219 | 1.69e-116 | ||||
The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain; The ligand binding domain of the DAX1 protein: DAX1 (dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on chromosome X gene 1) is a nuclear receptor with a typical ligand binding domain, but lacks the DNA binding domain. DAX1 plays an important role in the normal development of several hormone-producing tissues. Duplications of the region of the X chromosome containing DAX1 cause dosage sensitive sex reversal. DAX1 acts as a global repressor of many nuclear receptors, including SF-1, LRH-1, ERR, ER, AR and PR. DAX1 can form homodimer and heterodimerizes with its alternatively spliced isoform DAX1A and other nuclear receptors such as SHP, ERalpha and SF-1. Pssm-ID: 132764 Cd Length: 232 Bit Score: 331.79 E-value: 1.69e-116
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| HOLI | smart00430 | Ligand binding domain of hormone receptors; |
33-194 | 5.35e-14 | ||||
Ligand binding domain of hormone receptors; Pssm-ID: 214658 Cd Length: 163 Bit Score: 67.01 E-value: 5.35e-14
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| NR_Repeat | pfam14046 | Nuclear receptor repeat; This is a repeat domain involved in dimerization of nuclear receptors ... |
1-48 | 5.46e-13 | ||||
Nuclear receptor repeat; This is a repeat domain involved in dimerization of nuclear receptors proteins and in transcriptional regulation in general. It contains a Leu-Xaa-Xaa-Leu-Leu motif which has been characterized for the orphan nuclear receptor Dax-1, which represses the constitutively expressed protein Ad4BP/SF-1. The LXXLL motif plays in important role in binding of Dax-1 to Ad4BP/SF-1. The domain is subject to structure determination by the Joint Center of Structural Genomics. Pssm-ID: 464070 Cd Length: 47 Bit Score: 61.24 E-value: 5.46e-13
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| Hormone_recep | pfam00104 | Ligand-binding domain of nuclear hormone receptor; This all helical domain is involved in ... |
33-184 | 1.01e-05 | ||||
Ligand-binding domain of nuclear hormone receptor; This all helical domain is involved in binding the hormone in these receptors. Pssm-ID: 459675 [Multi-domain] Cd Length: 194 Bit Score: 44.65 E-value: 1.01e-05
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| Name | Accession | Description | Interval | E-value | ||||
| NR_LBD_Dax1 | cd07350 | The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain; The ... |
31-219 | 1.69e-116 | ||||
The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain; The ligand binding domain of the DAX1 protein: DAX1 (dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on chromosome X gene 1) is a nuclear receptor with a typical ligand binding domain, but lacks the DNA binding domain. DAX1 plays an important role in the normal development of several hormone-producing tissues. Duplications of the region of the X chromosome containing DAX1 cause dosage sensitive sex reversal. DAX1 acts as a global repressor of many nuclear receptors, including SF-1, LRH-1, ERR, ER, AR and PR. DAX1 can form homodimer and heterodimerizes with its alternatively spliced isoform DAX1A and other nuclear receptors such as SHP, ERalpha and SF-1. Pssm-ID: 132764 Cd Length: 232 Bit Score: 331.79 E-value: 1.69e-116
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| NR_LBD_Dax1_like | cd06951 | The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain; The ... |
32-219 | 3.50e-96 | ||||
The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain; The ligand binding domain of DAX1-like proteins: This orphan nuclear receptor family includes DAX1 (dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on chromosome X gene 1) and the Small Heterodimer Partner (SHP). Both receptors have a typical ligand binding domain, but lack the DNA binding domain, typical to almost all of the nuclear receptors. They function as a transcriptional coregulator by directly interacting with other nuclear receptors. DAX1 and SHP can form heterodimers with each other, as well as with many other nuclear receptors. In addition, DAX1 can also form homodimers. DAX1 plays an important role in the normal development of several hormone-producing tissues. SHP has shown to regulate a variety of target genes. Pssm-ID: 132749 [Multi-domain] Cd Length: 222 Bit Score: 279.77 E-value: 3.50e-96
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| NR_LBD_F2 | cd06930 | Ligand-binding domain of nuclear receptor family 2; Ligand-binding domain (LBD) of nuclear ... |
33-194 | 1.48e-47 | ||||
Ligand-binding domain of nuclear receptor family 2; Ligand-binding domain (LBD) of nuclear receptor (NR) family 2: This is one of the major subfamily of nuclear receptors, including some well known nuclear receptors such as glucocorticoid receptor (GR), mineralocorticoid receptor (MR), estrogen receptor (ER), progesterone receptor (PR), and androgen receptor (AR), other related receptors. Nuclear receptors form a superfamily of ligand-activated transcription regulators, which regulate various physiological functions, from development, reproduction, to homeostasis and metabolism in animals (metazoans). The family contains not only receptors for known ligands but also orphan receptors for which ligands do not exist or have not been identified. NRs share a common structural organization with a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD). Pssm-ID: 132728 [Multi-domain] Cd Length: 165 Bit Score: 154.31 E-value: 1.48e-47
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| NR_LBD_SHP | cd07349 | The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain; The ... |
33-221 | 1.74e-45 | ||||
The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain; The ligand binding domain of the Small Heterodimer Partner (SHP): SHP is a member of the nuclear receptor superfamily. SHP has a ligand binding domain, but lacks the DNA binding domain, typical to almost all of the nuclear receptors. It functions as a transcriptional coregulator by directly interacting with other nuclear receptors through its AF-2 motif. The closest relative of SHP is DAX1 and they can form heterodimer. SHP is an orphan receptor, lacking an identified ligand. Pssm-ID: 132763 Cd Length: 222 Bit Score: 150.74 E-value: 1.74e-45
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| NR_LBD | cd06157 | The ligand binding domain of nuclear receptors, a family of ligand-activated transcription ... |
33-194 | 2.05e-22 | ||||
The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Ligand-binding domain (LBD) of nuclear receptor (NR): Nuclear receptors form a superfamily of ligand-activated transcription regulators, which regulate various physiological functions in metazoans, from development, reproduction, to homeostasis and metabolism. The superfamily contains not only receptors for known ligands but also orphan receptors for which ligands do not exist or have not been identified. The members of the family include receptors of steroids, thyroid hormone, retinoids, cholesterol by-products, lipids and heme. With few exceptions, NRs share a common structural organization with a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD). Pssm-ID: 132726 Cd Length: 168 Bit Score: 89.67 E-value: 2.05e-22
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| NR_LBD_TR2_like | cd06952 | The ligand binding domain of the orphan nuclear receptors TR4 and TR2; The ligand binding ... |
31-214 | 6.62e-19 | ||||
The ligand binding domain of the orphan nuclear receptors TR4 and TR2; The ligand binding domain of the TR4 and TR2 (human testicular receptor 4 and 2): TR4 and TR2 are orphan nuclear receptors. Several isoforms of TR4 and TR2 have been isolated in various tissues. TR2 is abundantly expressed in the androgen-sensitive prostate. TR4 transcripts are expressed in many tissues, including central nervous system, adrenal gland, spleen, thyroid gland, and prostate. The expression of TR2 is negatively regulated by androgen, retinoids, and radiation. The expression of both mouse TR2 and TR4 is up-regulated by neurocytokine ciliary neurotrophic factor (CNTF) in mouse. It has shown that human TR2 binds to a wide spectrum of natural hormone response elements (HREs) with distinct affinities suggesting that TR2 may cross-talk with other gene expression regulation systems. The genes responding to TR2 or TR4 include genes that are regulated by retinoic acid receptor, vitamin D receptor, peroxisome proliferator-activated receptor. TR4/2 binds to HREs as a dimer. Like other members of the nuclea r receptor (NR) superfamily of ligand-activated transcription factors, TR2-like receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). Pssm-ID: 132750 Cd Length: 222 Bit Score: 81.61 E-value: 6.62e-19
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| NR_LBD_COUP-TF | cd06948 | Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member ... |
33-221 | 2.40e-16 | ||||
Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family; The ligand binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs): COUP-TFs are orphan members of the steroid/thyroid hormone receptor superfamily. They are expressed in many tissues and are involved in the regulation of several important biological processes, such as neurogenesis, organogenesis, cell fate determination, and metabolic homeostasis. In mammals two isoforms named COUP-TFI and COUP-TFII have been identified. Both genes show an exceptional homology and overlapping expression patterns, suggesting that they may serve redundant functions. Although COUP-TF was originally characterized as a transcriptional activator of the chicken ovalbumin gene, COUP-TFs are generally considered to be repressors of transcription for other nuclear hormone receptors, such as retinoic acid receptor (RAR), thyroid hormone receptor (TR), vitamin D receptor (VDR), peroxisome proliferator activated receptor (PPAR), and hepatocyte nuclear factor 4 (HNF4). Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, COUP-TFs have a central well cons erved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). Pssm-ID: 132746 Cd Length: 236 Bit Score: 75.18 E-value: 2.40e-16
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| NR_LBD_Tlx_PNR_like | cd06950 | The ligand binding domain of Tailless-like proteins, orphan nuclear receptors; The ligand ... |
33-209 | 9.22e-15 | ||||
The ligand binding domain of Tailless-like proteins, orphan nuclear receptors; The ligand binding domain of the photoreceptor cell-specific nuclear receptor (PNR) like family: This family includes photoreceptor cell-specific nuclear receptor (PNR), Tailless (TLX), and related receptors. TLX is an orphan receptor that is expressed by neural stem/progenitor cells in the adult brain of the subventricular zone (SVZ) and the dentate gyrus (DG). It plays a key role in neural development by promoting cell cycle progression and preventing apoptosis in the developing brain. PNR is expressed only in the outer layer of retinal photoreceptor cells. It may be involved in the signaling pathway regulating photoreceptor differentiation and/or maintenance. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, TLX and PNR have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). Pssm-ID: 132748 [Multi-domain] Cd Length: 206 Bit Score: 70.02 E-value: 9.22e-15
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| HOLI | smart00430 | Ligand binding domain of hormone receptors; |
33-194 | 5.35e-14 | ||||
Ligand binding domain of hormone receptors; Pssm-ID: 214658 Cd Length: 163 Bit Score: 67.01 E-value: 5.35e-14
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| NR_Repeat | pfam14046 | Nuclear receptor repeat; This is a repeat domain involved in dimerization of nuclear receptors ... |
1-48 | 5.46e-13 | ||||
Nuclear receptor repeat; This is a repeat domain involved in dimerization of nuclear receptors proteins and in transcriptional regulation in general. It contains a Leu-Xaa-Xaa-Leu-Leu motif which has been characterized for the orphan nuclear receptor Dax-1, which represses the constitutively expressed protein Ad4BP/SF-1. The LXXLL motif plays in important role in binding of Dax-1 to Ad4BP/SF-1. The domain is subject to structure determination by the Joint Center of Structural Genomics. Pssm-ID: 464070 Cd Length: 47 Bit Score: 61.24 E-value: 5.46e-13
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| NR_LBD_HNF4_like | cd06931 | The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in ... |
126-220 | 7.93e-12 | ||||
The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes; The ligand binding domain of hepatocyte nuclear factor 4 (HNF4) like proteins: HNF4 is a member of the nuclear receptor superfamily. HNF4 plays a key role in establishing and maintenance of hepatocyte differentiation in the liver. It is also expressed in gut, kidney, and pancreatic beta cells. HNF4 was originally classified as an orphan receptor, but later it is found that HNF4 binds with very high affinity to a variety of fatty acids. However, unlike other nuclear receptors, the ligands do not act as a molecular switch for HNF4. They seem to constantly bind to the receptor, which is constitutively active as a transcription activator. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, HNF4 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). The LBD domain is also responsible for recruiting co-activator proteins. More than 280 nuclear receptors are found in C. ele gans, most of which are originated from an explosive burst of duplications of HNF4. Pssm-ID: 132729 Cd Length: 222 Bit Score: 62.39 E-value: 7.93e-12
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| NR_LBD_Lrh-1 | cd07069 | The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor ... |
33-224 | 2.24e-08 | ||||
The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,; The ligand binding domain (LBD) of the liver receptor homolog-1 (LRH-1): LRH-1 belongs to nuclear hormone receptor superfamily, and is expressed mainly in the liver, intestine, exocrine pancreas, and ovary. Most nuclear receptors function as homodimer or heterodimers. However, LRH-1 binds DNA as a monomer, and is a regulator of bile-acid homeostasis, steroidogenesis, reverse cholesterol transport and the initial stages of embryonic development. Recently, phospholipids have been identified as potential ligand for LRH-1 and steroidogenic factor-1 (SF-1). Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, LRH-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). Pssm-ID: 132754 [Multi-domain] Cd Length: 241 Bit Score: 52.72 E-value: 2.24e-08
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| NR_LBD_Ftz-F1_like | cd06944 | The ligand binding domain of FTZ-F1 like nuclear receptors; The ligand binding domain of ... |
33-224 | 2.38e-07 | ||||
The ligand binding domain of FTZ-F1 like nuclear receptors; The ligand binding domain of FTZ-F1 like nuclear receptors: This nuclear receptor family includes at least three subgroups of receptors that function in embryo development and differentiation, and other processes. FTZ-F1 interacts with the cis-acting DNA motif of ftz gene, which required at several stages of development. Particularly, FTZ-F1 genes are strongly linked to steroid biosynthesis and sex-determination; LRH-1 is a regulator of bile-acid homeostasis, steroidogenesis, reverse cholesterol transport and the initial stages of embryonic development. SF-1 is an essential regulator of endocrine development and function and is considered a master regulator of reproduction; SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been identified as potential ligand for LRH-1 and steroidogenic factor-1 (SF-1). However, the ligand for FTZ-F1 has not yet been identified. Most nuclear receptors function as homodimer or heterodimers. However, LRH-1 and SF-1 bind to DNA as a monomer. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, receptors in this family have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). Pssm-ID: 132742 [Multi-domain] Cd Length: 237 Bit Score: 49.97 E-value: 2.38e-07
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| Hormone_recep | pfam00104 | Ligand-binding domain of nuclear hormone receptor; This all helical domain is involved in ... |
33-184 | 1.01e-05 | ||||
Ligand-binding domain of nuclear hormone receptor; This all helical domain is involved in binding the hormone in these receptors. Pssm-ID: 459675 [Multi-domain] Cd Length: 194 Bit Score: 44.65 E-value: 1.01e-05
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| NR_LBD_F1 | cd06929 | Ligand-binding domain of nuclear receptor family 1; Ligand-binding domain (LBD) of nuclear ... |
113-196 | 1.57e-05 | ||||
Ligand-binding domain of nuclear receptor family 1; Ligand-binding domain (LBD) of nuclear receptor (NR) family 1: This is one of the major subfamily of nuclear receptors, including thyroid receptor, retinoid acid receptor, ecdysone receptor, farnesoid X receptor, vitamin D receptor, and other related receptors. Nuclear receptors form a superfamily of ligand-activated transcription regulators, which regulate various physiological functions, from development, reproduction, to homeostasis and metabolism in animals (metazoans). The family contains not only receptors for known ligands but also orphan receptors for which ligands do not exist or have not been identified. NRs share a common structural organization with a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). Pssm-ID: 132727 Cd Length: 174 Bit Score: 43.75 E-value: 1.57e-05
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| NR_LBD_RXR_like | cd06943 | The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear ... |
126-204 | 2.11e-05 | ||||
The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily; The ligand binding domain of the retinoid X receptor (RXR) and Ultraspiracle (USP): This family includes two evolutionary related nuclear receptors: retinoid X receptor (RXR) and Ultraspiracle (USP). RXR is a nuclear receptor in mammalian and USP is its counterpart in invertebrates. The native ligand of retinoid X receptor is 9-cis retinoic acid (RA). RXR functions as a DNA binding partner by forming heterodimers with other nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR. RXRs can play different roles in these heterodimers. It acts either as a structural component of the heterodimer complex, required for DNA binding but not acting as a receptor or as both a structural and a functional component of the heterodimer, allowing 9-cis RA to signal through the corresponding heterodimer. In addition, RXR can also form homodimers, functioning as a receptor for 9-cis RA, independently of other nuclear receptors. Ultraspiracle (USP) plays similar roles as DNA binding partner of other nuclear rec eptors in invertebrates. USP has no known high-affinity ligand and is thought to be a silent component in the heterodimeric complex with partner receptors. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, RXR and USP have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). Pssm-ID: 132741 Cd Length: 207 Bit Score: 43.82 E-value: 2.11e-05
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| NR_LBD_SF-1 | cd07070 | The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear ... |
33-224 | 7.57e-04 | ||||
The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily; The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). Pssm-ID: 132755 Cd Length: 237 Bit Score: 39.55 E-value: 7.57e-04
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