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Conserved domains on  [gi|2531261501|gb|WJY65486|]
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ribosomal-protein-alanine N-acetyltransferase [Corynebacterium aquatimens]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11418877)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 83-161 7.13e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 53.12  E-value: 7.13e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2531261501  83 FPEFVRSYFEVAEIHVLPEAQGKGIGRTLLTTLLDGVPARHALLSTPEVAGEQNSAFGLYRSLGFQDVLRNFMYAGDHR 161
Cdd:COG0456     6 GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGDDA 84
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 83-161 7.13e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 53.12  E-value: 7.13e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2531261501  83 FPEFVRSYFEVAEIHVLPEAQGKGIGRTLLTTLLDGVPARHALLSTPEVAGEQNSAFGLYRSLGFQDVLRNFMYAGDHR 161
Cdd:COG0456     6 GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGDDA 84
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 96-172 1.65e-07

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 48.00  E-value: 1.65e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2531261501  96 IHVLPEAQGKGIGRTLLTTLLDGVPARHALLSTPEVAGEQNSAFGLYRSLGFQ--DVLRNFMYAGDHRPFAILgRSLPL 172
Cdd:PRK09491   69 IAVDPDYQRQGLGRALLEHLIDELEKRGVATLWLEVRASNAAAIALYESLGFNevTIRRNYYPTADGREDAII-MALPL 146
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 92-154 7.43e-07

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 46.17  E-value: 7.43e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2531261501  92 EVAEIHVLPEAQGKGIGRTLLTTLLDGVPARHALLSTPEVAGEQNSAFGLYRSLGFQDV--LRNF 154
Cdd:TIGR01575  56 HILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNIAAQALYKKLGFNEIaiRRNY 120
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 96-148 1.14e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 44.37  E-value: 1.14e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2531261501  96 IHVLPEAQGKGIGRTLLTTLLDgvpARHALLSTPEVAGEQNSAFGLYRSLGFQ 148
Cdd:pfam13508  34 LAVHPEYRGQGIGRALLEAAEA---AAKEGGIKLLELETTNRAAAFYEKLGFE 83
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 79-117 6.10e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 36.48  E-value: 6.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2531261501  79 VRGDFPEFVRSYFEVAEIHVLPEAQGKGIGRTLLTTLLD 117
Cdd:cd04301    14 ASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEE 52
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 83-161 7.13e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 53.12  E-value: 7.13e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2531261501  83 FPEFVRSYFEVAEIHVLPEAQGKGIGRTLLTTLLDGVPARHALLSTPEVAGEQNSAFGLYRSLGFQDVLRNFMYAGDHR 161
Cdd:COG0456     6 GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGDDA 84
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 96-172 1.65e-07

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 48.00  E-value: 1.65e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2531261501  96 IHVLPEAQGKGIGRTLLTTLLDGVPARHALLSTPEVAGEQNSAFGLYRSLGFQ--DVLRNFMYAGDHRPFAILgRSLPL 172
Cdd:PRK09491   69 IAVDPDYQRQGLGRALLEHLIDELEKRGVATLWLEVRASNAAAIALYESLGFNevTIRRNYYPTADGREDAII-MALPL 146
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 92-154 7.43e-07

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 46.17  E-value: 7.43e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2531261501  92 EVAEIHVLPEAQGKGIGRTLLTTLLDGVPARHALLSTPEVAGEQNSAFGLYRSLGFQDV--LRNF 154
Cdd:TIGR01575  56 HILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNIAAQALYKKLGFNEIaiRRNY 120
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 96-148 1.14e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 44.37  E-value: 1.14e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2531261501  96 IHVLPEAQGKGIGRTLLTTLLDgvpARHALLSTPEVAGEQNSAFGLYRSLGFQ 148
Cdd:pfam13508  34 LAVHPEYRGQGIGRALLEAAEA---AAKEGGIKLLELETTNRAAAFYEKLGFE 83
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
90-150 3.98e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 44.60  E-value: 3.98e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2531261501  90 YFEVAE--IHVLPEAQGKGIGRTLLTTLLDGVPAR--HALLSTpeVAGEQNSAFGLYRSLGFQDV 150
Cdd:COG1247    78 YRGTAEesIYVDPDARGRGIGRALLEALIERARARgyRRLVAV--VLADNEASIALYEKLGFEEV 140
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 98-158 5.61e-06

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 43.41  E-value: 5.61e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2531261501  98 VLPEAQGKGIGRTLLTTLLDGVPARHALLSTPEVaGEQNSAFGLYRSLGFQDVLRNFMYAG 158
Cdd:pfam13673  59 VDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTV-NASPYAVPFYEKLGFRATGPEQEFNG 118
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 91-152 6.35e-06

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 43.50  E-value: 6.35e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2531261501  91 FEVAEIHVLPEAQGKGIGRTLLTTLLDGVPARHALLSTPEVAGEQNSAFGLYRSLGFQDVLR 152
Cdd:COG0454    59 LELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYERLGFKEIER 120
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 79-147 2.87e-05

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 41.35  E-value: 2.87e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2531261501  79 VRGDFPEFVRSYFEVAEIHVLPEAQGKGIGRTLLTTLLDGVPARHALLSTPEVAGEQNSAFGLYRSLGF 147
Cdd:pfam00583  48 ASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
98-162 8.09e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 40.55  E-value: 8.09e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2531261501  98 VLPEAQGKGIGRTLLTTLLDGV---PARHALLSTpevageQNSAFGLYRSLGFQDVLRNFMYAG-DHRP 162
Cdd:COG2153    66 VLPEYRGQGLGRALMEAAIEEArerGARRIVLSA------QAHAVGFYEKLGFVPVGEEFLEAGiPHID 128
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 92-150 1.08e-04

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 39.98  E-value: 1.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2531261501  92 EVAEIH---VLPEAQGKGIGRTLLTTLLDgvparHA---------LLSTPEvageqnsAFGLYRSLGFQDV 150
Cdd:COG1246    51 DLAELRslaVHPDYRGRGIGRRLLEALLA-----EArelglkrlfLLTTSA-------AIHFYEKLGFEEI 109
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
88-166 1.29e-04

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 40.07  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2531261501  88 RSYFEVAEIHVLPEAQGKGIGRTLLTTLLDGVPARHA----LLSTPEVAgeqnsafGLYRSLGFQDVLRNFMYAGDHRPF 163
Cdd:COG3153    65 GPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGAravvLLGDPSLL-------PFYERFGFRPAGELGLTLGPDEVF 137


                  ...
gi 2531261501 164 AIL 166
Cdd:COG3153   138 LAK 140
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
93-150 5.68e-04

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 37.20  E-value: 5.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2531261501  93 VAEIH---VLPEAQGKGIGRTLLTTLLDGVPARHALLSTPEVAGEQNSAFGLYRSLGFQDV 150
Cdd:COG3393    15 VAEISgvyTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPV 75
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 79-117 6.10e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 36.48  E-value: 6.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2531261501  79 VRGDFPEFVRSYFEVAEIHVLPEAQGKGIGRTLLTTLLD 117
Cdd:cd04301    14 ASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEE 52
PRK10514 PRK10514
putative acetyltransferase; Provisional
 98-148 3.46e-03

putative acetyltransferase; Provisional


Pssm-ID: 182510 [Multi-domain]  Cd Length: 145  Bit Score: 36.13  E-value: 3.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2531261501  98 VLPEAQGKGIGRTLLttlldgvpaRHALLSTPEVA---GEQNS-AFGLYRSLGFQ 148
Cdd:PRK10514   77 VDPDVRGCGVGRMLV---------EHALSLHPELTtdvNEQNEqAVGFYKKMGFK 122
PRK10562 PRK10562
putative acetyltransferase; Provisional
 93-148 5.76e-03

putative acetyltransferase; Provisional


Pssm-ID: 236715 [Multi-domain]  Cd Length: 145  Bit Score: 35.43  E-value: 5.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2531261501  93 VAEIHVLPEAQGKGIGRtlltTLLDGVPARHALLSTpEVAGEQNSAFGLYRSLGFQ 148
Cdd:PRK10562   71 VGALFVAPKAVRRGIGK----ALMQHVQQRYPHLSL-EVYQKNQRAVNFYHAQGFR 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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