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Conserved domains on  [gi|445941611|ref|WP_000019466|]
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MULTISPECIES: IS5/IS1182 family transposase, partial [Enterobacteriaceae]

Protein Classification

transposase( domain architecture ID 1000886)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0004803|GO:0032196|GO:0003677
PubMed:  26104718|15102449|33172005

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IS5 super family cl34540
Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];
1-106 4.09e-50

Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];


The actual alignment was detected with superfamily member COG3039:

Pssm-ID: 442273 [Multi-domain]  Cd Length: 316  Bit Score: 160.42  E-value: 4.09e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445941611   1 MSHQLTFADSEFSTKRRQTRKEIFLSRMEQILPWQNMVEVIEPFYPKAGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDA 80
Cdd:COG3039    1 MKQQLFAADERYAKKKKQTRPLLFLEEMIDVVPWALLLDIIEPRYPKGKGGRPPYPLERMLRILFLQQWYNLSDPAMEDA 80

                         90       100
                 ....*....|....*....|....*.
gi 445941611  81 LYEIASMRLFARLSLDSALPDRTTIM 106
Cdd:COG3039   81 LYDRLSFRRFAGLDLSDRVPDETTIL 106
 
Name Accession Description Interval E-value
IS5 COG3039
Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];
1-106 4.09e-50

Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];


Pssm-ID: 442273 [Multi-domain]  Cd Length: 316  Bit Score: 160.42  E-value: 4.09e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445941611   1 MSHQLTFADSEFSTKRRQTRKEIFLSRMEQILPWQNMVEVIEPFYPKAGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDA 80
Cdd:COG3039    1 MKQQLFAADERYAKKKKQTRPLLFLEEMIDVVPWALLLDIIEPRYPKGKGGRPPYPLERMLRILFLQQWYNLSDPAMEDA 80

                         90       100
                 ....*....|....*....|....*.
gi 445941611  81 LYEIASMRLFARLSLDSALPDRTTIM 106
Cdd:COG3039   81 LYDRLSFRRFAGLDLSDRVPDETTIL 106
transpos_IS5_4 NF033581
IS5 family transposase;
24-106 1.91e-30

IS5 family transposase;


Pssm-ID: 468098 [Multi-domain]  Cd Length: 284  Bit Score: 108.95  E-value: 1.91e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445941611  24 FLSRMEQILPWQNMVEVIEPFYPK-AGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDALYEIASMRLFARLSLDsALPDR 102
Cdd:NF033581   1 RLFRRLSGVPWETFEALIEPLYPKrAGRGRPPYPPELMLRILLLQTLYYLRDERLEEQLYDYLSFRAFVGLSED-DVPDA 79


                 ....
gi 445941611 103 TTIM 106
Cdd:NF033581  80 STIW 83
DUF772 pfam05598
Transposase domain (DUF772); This presumed domain is found at the N-terminus of many proteins ...
 51-105 4.93e-14

Transposase domain (DUF772); This presumed domain is found at the N-terminus of many proteins found in transposons.


Pssm-ID: 461687 [Multi-domain]  Cd Length: 71  Bit Score: 61.35  E-value: 4.93e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 445941611   51 GRRPYPLETMLRIHCMQHWYNL-SDGAMEDALYEIASMRLFARLSLDS-ALPDRTTI 105
Cdd:pfam05598   1 GRPAYPPEMMLKALLLQYLYGLrSDRQLEEALRDNLSFRWFLGLDLDDdPVPDHSTL 57
 
Name Accession Description Interval E-value
IS5 COG3039
Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];
1-106 4.09e-50

Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];


Pssm-ID: 442273 [Multi-domain]  Cd Length: 316  Bit Score: 160.42  E-value: 4.09e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445941611   1 MSHQLTFADSEFSTKRRQTRKEIFLSRMEQILPWQNMVEVIEPFYPKAGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDA 80
Cdd:COG3039    1 MKQQLFAADERYAKKKKQTRPLLFLEEMIDVVPWALLLDIIEPRYPKGKGGRPPYPLERMLRILFLQQWYNLSDPAMEDA 80

                         90       100
                 ....*....|....*....|....*.
gi 445941611  81 LYEIASMRLFARLSLDSALPDRTTIM 106
Cdd:COG3039   81 LYDRLSFRRFAGLDLSDRVPDETTIL 106
transpos_IS5_4 NF033581
IS5 family transposase;
24-106 1.91e-30

IS5 family transposase;


Pssm-ID: 468098 [Multi-domain]  Cd Length: 284  Bit Score: 108.95  E-value: 1.91e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445941611  24 FLSRMEQILPWQNMVEVIEPFYPK-AGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDALYEIASMRLFARLSLDsALPDR 102
Cdd:NF033581   1 RLFRRLSGVPWETFEALIEPLYPKrAGRGRPPYPPELMLRILLLQTLYYLRDERLEEQLYDYLSFRAFVGLSED-DVPDA 79


                 ....
gi 445941611 103 TTIM 106
Cdd:NF033581  80 STIW 83
DUF772 pfam05598
Transposase domain (DUF772); This presumed domain is found at the N-terminus of many proteins ...
 51-105 4.93e-14

Transposase domain (DUF772); This presumed domain is found at the N-terminus of many proteins found in transposons.


Pssm-ID: 461687 [Multi-domain]  Cd Length: 71  Bit Score: 61.35  E-value: 4.93e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 445941611   51 GRRPYPLETMLRIHCMQHWYNL-SDGAMEDALYEIASMRLFARLSLDS-ALPDRTTI 105
Cdd:pfam05598   1 GRPAYPPEMMLKALLLQYLYGLrSDRQLEEALRDNLSFRWFLGLDLDDdPVPDHSTL 57
COG3666 COG3666
Transposase, IS1182 family [Mobilome: prophages, transposons];
39-105 5.92e-06

Transposase, IS1182 family [Mobilome: prophages, transposons];


Pssm-ID: 442883 [Multi-domain]  Cd Length: 169  Bit Score: 42.57  E-value: 5.92e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 445941611  39 EVIEPFYPkAGNGRRPYPLETMLRIHCMQHWYNL-SDGAMEDALYEIASMRLFARLSLDSALPDRTTI 105
Cdd:COG3666   44 SELEKLYS-ADTGRPAYDPEMLLKLLLYGYLEGIrSSRQLEEACRYNLAFRWLLGLELDDPVPDHSTI 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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