NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|445946052|ref|WP_000023907|]
View 

MULTISPECIES: LutB/LldF family L-lactate oxidation iron-sulfur protein [Enterobacteriaceae]

Protein Classification

iron-sulfur cluster-binding protein( domain architecture ID 11489036)

iron-sulfur cluster-binding protein similar to Bacillus subtilis lactate utilization protein B that is essential for L-lactate degradation and allows cells to grow with lactate as the sole carbon source

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TIGR00273 TIGR00273
iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding ...
 18-453 0e+00

iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding motif C-x(2)-C-x(2)-C-x(3)-CP followed by either a perfect or imperfect (the first Cys replaced by Ser) second copy. Members probably bind two 4fe-4S iron-sulfur clusters. [Energy metabolism, Electron transport]


:

Pssm-ID: 129374 [Multi-domain]  Cd Length: 432  Bit Score: 801.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052   18 IEDPIMRKAVANAQQRIGANRQKMVDELGHWEEWRDRAAQIRDHVLSNLDAYLYQLSEKVTQNGGHVWFAKTKEDATRYI 97
Cdd:TIGR00273   1 IKDGILREALRNAQERLRANRKLLVEELGYWEEWRELVKEIKLKVLENLDFYLDQLKENVTQRGGHVYYAKTAEEARKII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052   98 LQVAQRKNARKVVKSKSMVTEEIGVNHVLQDAGIQVIETDLGEYILQLDQDPPSHVVVPAIHKDRHQIRRVLHERLGYEG 177
Cdd:TIGR00273  81 GKVAQEKNGKKVVKSKSMVSEEIGLNEVLEKIGIEVWETDLGELILQLDGDPPSHIVVPALHKNRQQIGEILKERLGYEG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  178 PETPEAMTLFIRQKIREDFLSAEIGITGCNFAVAETGSVCLVTNEGNARMCTTLPKTHIAVMGMERIAPTFAEVDVLITM 257
Cdd:TIGR00273 161 EESPEVLAREARKFMREKFLSADIGISGCNFAIAETGSIFLVENEGNGRLSTTLPKTHIAVMGIEKIVPTFDDELVLKSM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  258 LARSAVGARLTGYNTWLTGPREAGHVDGPEEFHLVIVDNGRSEVLASEFRDVLRCIRCGACMNTCPAYRHIGGHGYGSIY 337
Cdd:TIGR00273 241 LARSAVGTRLTAYINVLTGPRQEGDVDGPEEFHLILLDNGRSNILATEFREVLACIRCGACQNECPVYRHIGGHWYGSIY 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  338 PGPIGAVISPLLGGYKDFKDLPYACSLCTACDSVCPVRIPLSKLILRHRRVMAEKGITAKAEQRAIKMFAYANSHPGLWK 417
Cdd:TIGR00273 321 PGPIGAVWSPLLGGYTDYKHLPYLSSLCGACREVCPVKIPLPELIREHRSDKVEKGRHSGMEKLAMKMFAKMASDGALWK 400

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 445946052  418 VGMMagahAASWFINGGKTPLKFGAISDWMEARDLP 453
Cdd:TIGR00273 401 FGLK----MAQFFSPLGKLLAPIGPVKEWASVRDLP 432
 
Name Accession Description Interval E-value
TIGR00273 TIGR00273
iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding ...
 18-453 0e+00

iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding motif C-x(2)-C-x(2)-C-x(3)-CP followed by either a perfect or imperfect (the first Cys replaced by Ser) second copy. Members probably bind two 4fe-4S iron-sulfur clusters. [Energy metabolism, Electron transport]


Pssm-ID: 129374 [Multi-domain]  Cd Length: 432  Bit Score: 801.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052   18 IEDPIMRKAVANAQQRIGANRQKMVDELGHWEEWRDRAAQIRDHVLSNLDAYLYQLSEKVTQNGGHVWFAKTKEDATRYI 97
Cdd:TIGR00273   1 IKDGILREALRNAQERLRANRKLLVEELGYWEEWRELVKEIKLKVLENLDFYLDQLKENVTQRGGHVYYAKTAEEARKII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052   98 LQVAQRKNARKVVKSKSMVTEEIGVNHVLQDAGIQVIETDLGEYILQLDQDPPSHVVVPAIHKDRHQIRRVLHERLGYEG 177
Cdd:TIGR00273  81 GKVAQEKNGKKVVKSKSMVSEEIGLNEVLEKIGIEVWETDLGELILQLDGDPPSHIVVPALHKNRQQIGEILKERLGYEG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  178 PETPEAMTLFIRQKIREDFLSAEIGITGCNFAVAETGSVCLVTNEGNARMCTTLPKTHIAVMGMERIAPTFAEVDVLITM 257
Cdd:TIGR00273 161 EESPEVLAREARKFMREKFLSADIGISGCNFAIAETGSIFLVENEGNGRLSTTLPKTHIAVMGIEKIVPTFDDELVLKSM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  258 LARSAVGARLTGYNTWLTGPREAGHVDGPEEFHLVIVDNGRSEVLASEFRDVLRCIRCGACMNTCPAYRHIGGHGYGSIY 337
Cdd:TIGR00273 241 LARSAVGTRLTAYINVLTGPRQEGDVDGPEEFHLILLDNGRSNILATEFREVLACIRCGACQNECPVYRHIGGHWYGSIY 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  338 PGPIGAVISPLLGGYKDFKDLPYACSLCTACDSVCPVRIPLSKLILRHRRVMAEKGITAKAEQRAIKMFAYANSHPGLWK 417
Cdd:TIGR00273 321 PGPIGAVWSPLLGGYTDYKHLPYLSSLCGACREVCPVKIPLPELIREHRSDKVEKGRHSGMEKLAMKMFAKMASDGALWK 400

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 445946052  418 VGMMagahAASWFINGGKTPLKFGAISDWMEARDLP 453
Cdd:TIGR00273 401 FGLK----MAQFFSPLGKLLAPIGPVKEWASVRDLP 432
LutB COG1139
L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and ...
 1-464 0e+00

L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and conversion];


Pssm-ID: 440754 [Multi-domain]  Cd Length: 465  Bit Score: 776.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052   1 MSiKTSNTDFKTRIRQQIEDPIMRKAVANAQQRIGANRQKMVDELGHWEEWRDRAAQIRDHVLSNLDAYLYQLSEKVTQN 80
Cdd:COG1139    1 MS-KASSEDFKERAREALADEQLRKALDRATDTLRAKRAKAVAELPDWEALREAARAIKDHALANLDEYLEQFEANATAN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  81 GGHVWFAKTKEDATRYILQVAQRKNARKVVKSKSMVTEEIGVNHVLQDAGIQVIETDLGEYILQLDQDPPSHVVVPAIHK 160
Cdd:COG1139   80 GGHVHWARDAEEANRIVLDIAREKGAKKVVKSKSMVTEEIGLNEALEAAGIEVVETDLGEYIVQLAGEPPSHIVMPAIHK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 161 DRHQIRRVLHERLGY-EGPETPEAMTLFIRQKIREDFLSAEIGITGCNFAVAETGSVCLVTNEGNARMCTTLPKTHIAVM 239
Cdd:COG1139  160 NREQIAELFHEKLGTePLTDDPEELTRAAREHLREKFLEADVGITGANFAVAETGTIVLVTNEGNARLCTTLPKVHIAVM 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 240 GMERIAPTFAEVDVLITMLARSAVGARLTGYNTWLTGPREAGHVDGPEEFHLVIVDNGRSEVLA-SEFRDVLRCIRCGAC 318
Cdd:COG1139  240 GIEKLVPTLEDLEVFLRLLPRSATGQRITTYTSLITGPRRPGEGDGPEEFHLVLLDNGRSAMLAdPEFREALRCIRCGAC 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 319 MNTCPAYRHIGGHGYGSIYPGPIGAVISPLLGGYKDFKDLPYACSLCTACDSVCPVRIPLSKLILRHRRVMAEKGITAKA 398
Cdd:COG1139  320 LNVCPVYRRVGGHAYGSVYPGPIGAVLTPLLHGLEKAADLPYASTLCGACTEVCPVKIPIPELLLELRERIVEEGLTPPA 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 445946052 399 EQRAIKMFAYANSHPGLWKVGMMAGAHAASWFINGGKTPLKFGAISDWMEARDLPEADGESFRSWF 464
Cdd:COG1139  400 EKLAMKAWAWVMSNPKLYRLALRLARRALKLLPRGGGIRRLPGPLGGWTKGRDLPAPAKESFRDWW 465
LUD_dom pfam02589
LUD domain; This entry represents a domain found in lactate utilization proteins B (LutB) and ...
 70-294 4.95e-56

LUD domain; This entry represents a domain found in lactate utilization proteins B (LutB) and C (LutC), as well as several uncharacterized proteins. LutB and LutC are encoded by th conserved LutABC operon in bacteria. They are involved in lactate utilization and is implicated in the oxidative conversion of L-lactate into pyruvate


Pssm-ID: 426855  Cd Length: 188  Bit Score: 184.35  E-value: 4.95e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052   70 LYQLSEKVTQNGGHVWFAKTKEDATRYILQVAQRKNArkvvksksmvteeigvnhvlqdaGIQVIETDLGEYILqldqdp 149
Cdd:pfam02589   1 LEEFKENLEANGAEVYYAKTAEEALEYILELIKEGGV-----------------------VSEGGSTDLGELGL------ 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  150 pshvvVPAIHKDRHQIRRVLHERLgyegpetpeamTLFIRQKIREDFLSAEIGITGCNFAVAETGSVCLVTNEGNARMCT 229
Cdd:pfam02589  52 -----APALHSGRYEVLDLFEEKL-----------TAEAREELREKALTADVGITGANFAIAETGTLVLVDGEGNRRLLS 115

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 445946052  230 TLPKTHIAVMGMERIAPTFAEVDVLITMLARSAVGARLTGYNTWLTGPREAGHVD--------GPEEFHLVIV 294
Cdd:pfam02589 116 FLPKVHIAVVGINKIVPDLEDAVKRLRLAPRNATRQKLTPYITFISGPSRTADIElvlvvgvhGPGELHVILV 188
glpC PRK11168
anaerobic glycerol-3-phosphate dehydrogenase subunit C;
312-473 3.60e-08

anaerobic glycerol-3-phosphate dehydrogenase subunit C;


Pssm-ID: 236869 [Multi-domain]  Cd Length: 396  Bit Score: 55.26  E-value: 3.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 312 CIRCGACMNTCPAYRhigghgYGSIYPGP-------------IGAVISPLLGgykdfkdlpYaCSLCTACDSVCPVRIPL 378
Cdd:PRK11168   9 CIKCTVCTTACPVAR------VNPLYPGPkqagpdgerlrlkDGALYDESLK---------Y-CSNCKRCEVACPSGVKI 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 379 SKLILRHRRVMAEKGItAKAEQRAIkmfayanSHPGLwkVGMMAGAHAasWFINggkTPLKFGAISDWMEA-------RD 451
Cdd:PRK11168  73 GDIIQRARAKYVTERG-PPLRDRIL-------SHTDL--MGSLATPFA--PLVN---AATGLKPVRWLLEKtlgidhrRP 137

                        170       180
                 ....*....|....*....|..
gi 445946052 452 LPEADGESFRSWFKKHQAQEKK 473
Cdd:PRK11168 138 LPKYAFGTFRRWYRKQAAQQAQ 159
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 311-374 6.02e-06

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 45.47  E-value: 6.02e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 445946052 311 RCIRCGACMNTCPayrhigghgYGSIYPGPIGAVISPLLggyKDFKdlpyACSLCTACDSVCPV 374
Cdd:cd10549    7 KCIGCGICVKACP---------TDAIELGPNGAIARGPE---IDED----KCVFCGACVEVCPT 54
 
Name Accession Description Interval E-value
TIGR00273 TIGR00273
iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding ...
 18-453 0e+00

iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding motif C-x(2)-C-x(2)-C-x(3)-CP followed by either a perfect or imperfect (the first Cys replaced by Ser) second copy. Members probably bind two 4fe-4S iron-sulfur clusters. [Energy metabolism, Electron transport]


Pssm-ID: 129374 [Multi-domain]  Cd Length: 432  Bit Score: 801.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052   18 IEDPIMRKAVANAQQRIGANRQKMVDELGHWEEWRDRAAQIRDHVLSNLDAYLYQLSEKVTQNGGHVWFAKTKEDATRYI 97
Cdd:TIGR00273   1 IKDGILREALRNAQERLRANRKLLVEELGYWEEWRELVKEIKLKVLENLDFYLDQLKENVTQRGGHVYYAKTAEEARKII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052   98 LQVAQRKNARKVVKSKSMVTEEIGVNHVLQDAGIQVIETDLGEYILQLDQDPPSHVVVPAIHKDRHQIRRVLHERLGYEG 177
Cdd:TIGR00273  81 GKVAQEKNGKKVVKSKSMVSEEIGLNEVLEKIGIEVWETDLGELILQLDGDPPSHIVVPALHKNRQQIGEILKERLGYEG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  178 PETPEAMTLFIRQKIREDFLSAEIGITGCNFAVAETGSVCLVTNEGNARMCTTLPKTHIAVMGMERIAPTFAEVDVLITM 257
Cdd:TIGR00273 161 EESPEVLAREARKFMREKFLSADIGISGCNFAIAETGSIFLVENEGNGRLSTTLPKTHIAVMGIEKIVPTFDDELVLKSM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  258 LARSAVGARLTGYNTWLTGPREAGHVDGPEEFHLVIVDNGRSEVLASEFRDVLRCIRCGACMNTCPAYRHIGGHGYGSIY 337
Cdd:TIGR00273 241 LARSAVGTRLTAYINVLTGPRQEGDVDGPEEFHLILLDNGRSNILATEFREVLACIRCGACQNECPVYRHIGGHWYGSIY 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  338 PGPIGAVISPLLGGYKDFKDLPYACSLCTACDSVCPVRIPLSKLILRHRRVMAEKGITAKAEQRAIKMFAYANSHPGLWK 417
Cdd:TIGR00273 321 PGPIGAVWSPLLGGYTDYKHLPYLSSLCGACREVCPVKIPLPELIREHRSDKVEKGRHSGMEKLAMKMFAKMASDGALWK 400

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 445946052  418 VGMMagahAASWFINGGKTPLKFGAISDWMEARDLP 453
Cdd:TIGR00273 401 FGLK----MAQFFSPLGKLLAPIGPVKEWASVRDLP 432
LutB COG1139
L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and ...
 1-464 0e+00

L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and conversion];


Pssm-ID: 440754 [Multi-domain]  Cd Length: 465  Bit Score: 776.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052   1 MSiKTSNTDFKTRIRQQIEDPIMRKAVANAQQRIGANRQKMVDELGHWEEWRDRAAQIRDHVLSNLDAYLYQLSEKVTQN 80
Cdd:COG1139    1 MS-KASSEDFKERAREALADEQLRKALDRATDTLRAKRAKAVAELPDWEALREAARAIKDHALANLDEYLEQFEANATAN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  81 GGHVWFAKTKEDATRYILQVAQRKNARKVVKSKSMVTEEIGVNHVLQDAGIQVIETDLGEYILQLDQDPPSHVVVPAIHK 160
Cdd:COG1139   80 GGHVHWARDAEEANRIVLDIAREKGAKKVVKSKSMVTEEIGLNEALEAAGIEVVETDLGEYIVQLAGEPPSHIVMPAIHK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 161 DRHQIRRVLHERLGY-EGPETPEAMTLFIRQKIREDFLSAEIGITGCNFAVAETGSVCLVTNEGNARMCTTLPKTHIAVM 239
Cdd:COG1139  160 NREQIAELFHEKLGTePLTDDPEELTRAAREHLREKFLEADVGITGANFAVAETGTIVLVTNEGNARLCTTLPKVHIAVM 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 240 GMERIAPTFAEVDVLITMLARSAVGARLTGYNTWLTGPREAGHVDGPEEFHLVIVDNGRSEVLA-SEFRDVLRCIRCGAC 318
Cdd:COG1139  240 GIEKLVPTLEDLEVFLRLLPRSATGQRITTYTSLITGPRRPGEGDGPEEFHLVLLDNGRSAMLAdPEFREALRCIRCGAC 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 319 MNTCPAYRHIGGHGYGSIYPGPIGAVISPLLGGYKDFKDLPYACSLCTACDSVCPVRIPLSKLILRHRRVMAEKGITAKA 398
Cdd:COG1139  320 LNVCPVYRRVGGHAYGSVYPGPIGAVLTPLLHGLEKAADLPYASTLCGACTEVCPVKIPIPELLLELRERIVEEGLTPPA 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 445946052 399 EQRAIKMFAYANSHPGLWKVGMMAGAHAASWFINGGKTPLKFGAISDWMEARDLPEADGESFRSWF 464
Cdd:COG1139  400 EKLAMKAWAWVMSNPKLYRLALRLARRALKLLPRGGGIRRLPGPLGGWTKGRDLPAPAKESFRDWW 465
LUD_dom pfam02589
LUD domain; This entry represents a domain found in lactate utilization proteins B (LutB) and ...
 70-294 4.95e-56

LUD domain; This entry represents a domain found in lactate utilization proteins B (LutB) and C (LutC), as well as several uncharacterized proteins. LutB and LutC are encoded by th conserved LutABC operon in bacteria. They are involved in lactate utilization and is implicated in the oxidative conversion of L-lactate into pyruvate


Pssm-ID: 426855  Cd Length: 188  Bit Score: 184.35  E-value: 4.95e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052   70 LYQLSEKVTQNGGHVWFAKTKEDATRYILQVAQRKNArkvvksksmvteeigvnhvlqdaGIQVIETDLGEYILqldqdp 149
Cdd:pfam02589   1 LEEFKENLEANGAEVYYAKTAEEALEYILELIKEGGV-----------------------VSEGGSTDLGELGL------ 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  150 pshvvVPAIHKDRHQIRRVLHERLgyegpetpeamTLFIRQKIREDFLSAEIGITGCNFAVAETGSVCLVTNEGNARMCT 229
Cdd:pfam02589  52 -----APALHSGRYEVLDLFEEKL-----------TAEAREELREKALTADVGITGANFAIAETGTLVLVDGEGNRRLLS 115

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 445946052  230 TLPKTHIAVMGMERIAPTFAEVDVLITMLARSAVGARLTGYNTWLTGPREAGHVD--------GPEEFHLVIV 294
Cdd:pfam02589 116 FLPKVHIAVVGINKIVPDLEDAVKRLRLAPRNATRQKLTPYITFISGPSRTADIElvlvvgvhGPGELHVILV 188
Fer4_8 pfam13183
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 311-376 3.43e-16

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 433017 [Multi-domain]  Cd Length: 64  Bit Score: 72.73  E-value: 3.43e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 445946052  311 RCIRCGACMNTCPAYRHIGGHGYGSIYPGPIGAVIspLLGGYKDFKDLPYACSLCTACDSVCPVRI 376
Cdd:pfam13183   1 RCIRCGACLAACPVYLVTGGRFPGDPRGGAAALLG--RLEALEGLAEGLWLCTLCGACTEVCPVGI 64
LutC COG1556
L-lactate utilization protein LutC, contains LUD domain [Energy production and conversion];
72-295 4.28e-15

L-lactate utilization protein LutC, contains LUD domain [Energy production and conversion];


Pssm-ID: 441165  Cd Length: 206  Bit Score: 73.74  E-value: 4.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  72 QLSEKVTQNGGHVWFAKTKEDATRYILQVAQRKNARKVVksksmvteeigvnhvLQDAGIQVIETDLGEYILQLDQdpps 151
Cdd:COG1556   41 LFVERLEAVGGEVVRVTTEAELPAALAELLAEAGLKRIV---------------VPEPGLPAALQLAWDPLEELED---- 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 152 hvvvpaihkdrhqirrvlherlgyegpetpeamtlfirqkiREDFLSAEIGITGCNFAVAETGSVCLVTNEGNARMCTTL 231
Cdd:COG1556  102 -----------------------------------------PAALEDADVGITGAEFGIAETGTIVLDSGPDQGRALSLL 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 445946052 232 PKTHIAVMGMERIAPTFAEVdvlitmLARSAVGARLTGYNTWLTGP-REA--------GhVDGPEEFHLVIVD 295
Cdd:COG1556  141 PEHHIVVVPASQIVPTMHEA------YARLREKAGLPRNITFISGPsKTAdieqtlvlG-AHGPRRLHVILVE 206
LutB_C pfam11870
Lactate utilization protein B, C-terminal; This domain is functionally uncharacterized. This ...
 383-468 7.49e-12

Lactate utilization protein B, C-terminal; This domain is functionally uncharacterized. This domain is found at the C-terminal of a family of 4Fe-4S, iron-sulphur cluster binding proteins, including Lactate utilization protein B (LutB). These proteins have a perfect 4Fe-4S binding motif C-x(2)-C-x(2)-C-x(3)-CP followed by either a perfect or imperfect (the first Cys replaced by Ser) second copy. Members probably bind two 4Fe-4S iron-sulphur clusters. This domain is found in LutB proteins in association with the LUD domain (pfam02589) and usually Fer4_8 (pfam13183). The LutABC operon is involved in lactate-utilization and is essential.


Pssm-ID: 432147 [Multi-domain]  Cd Length: 86  Bit Score: 61.14  E-value: 7.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052  383 LRHR------RVMAEKGITA-KAEQRAIKMFAYANSHPGLWKvgmmAGAHAASWFinGGKTPLKFGAisdWMEARDLPEA 455
Cdd:pfam11870   2 LRHEpvgqgpGVIKGQGAKRsAAERLAWKGFALAASSPGLYR----LGTWLATRF--RGLLPSKLKA---WTRVRTFPKP 72

                          90
                  ....*....|...
gi 445946052  456 DGESFRSWFKKHQ 468
Cdd:pfam11870  73 AARSLHDLAKERG 85
GlpC COG0247
Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy ...
 307-407 3.38e-11

Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy production and conversion];


Pssm-ID: 440017 [Multi-domain]  Cd Length: 420  Bit Score: 65.10  E-value: 3.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 307 RDVLRCIRCGACMNTCPAYRHIGGHGYG---------SIYPGPIGAVISPllggykDFKDLPYACSLCTACDSVCPVRIP 377
Cdd:COG0247   75 DALDACVGCGFCRAMCPSYKATGDEKDSprgrinllrEVLEGELPLDLSE------EVYEVLDLCLTCKACETACPSGVD 148

                         90       100       110
                 ....*....|....*....|....*....|
gi 445946052 378 LSKLILRHRRVMAEKGITaKAEQRAIKMFA 407
Cdd:COG0247  149 IADLIAEARAQLVERGGR-PLRDRLLRTFP 177
Fer4_17 pfam13534
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 311-373 2.02e-08

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 433287 [Multi-domain]  Cd Length: 61  Bit Score: 50.54  E-value: 2.02e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 445946052  311 RCIRCGACMNTCPAYRHIGGHGYgsiypGPIGAVISPLLGGYKDfKDLPYACSLCTACDSVCP 373
Cdd:pfam13534   1 RCIQCGCCVDECPRYLLNGDEPK-----KLMRAAYLGDLEELQA-NKVANLCSECGLCEYACP 57
glpC PRK11168
anaerobic glycerol-3-phosphate dehydrogenase subunit C;
312-473 3.60e-08

anaerobic glycerol-3-phosphate dehydrogenase subunit C;


Pssm-ID: 236869 [Multi-domain]  Cd Length: 396  Bit Score: 55.26  E-value: 3.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 312 CIRCGACMNTCPAYRhigghgYGSIYPGP-------------IGAVISPLLGgykdfkdlpYaCSLCTACDSVCPVRIPL 378
Cdd:PRK11168   9 CIKCTVCTTACPVAR------VNPLYPGPkqagpdgerlrlkDGALYDESLK---------Y-CSNCKRCEVACPSGVKI 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 379 SKLILRHRRVMAEKGItAKAEQRAIkmfayanSHPGLwkVGMMAGAHAasWFINggkTPLKFGAISDWMEA-------RD 451
Cdd:PRK11168  73 GDIIQRARAKYVTERG-PPLRDRIL-------SHTDL--MGSLATPFA--PLVN---AATGLKPVRWLLEKtlgidhrRP 137

                        170       180
                 ....*....|....*....|..
gi 445946052 452 LPEADGESFRSWFKKHQAQEKK 473
Cdd:PRK11168 138 LPKYAFGTFRRWYRKQAAQQAQ 159
HdrC COG1150
Heterodisulfide reductase, subunit C [Energy production and conversion];
308-392 3.61e-07

Heterodisulfide reductase, subunit C [Energy production and conversion];


Pssm-ID: 440764 [Multi-domain]  Cd Length: 79  Bit Score: 47.59  E-value: 3.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 308 DVLRCIRCGACMNTCPAYRHigghgyGSIYPGPIgaVISPLLGGYKDF--KDLPYACSLCTACDSVCPVRIPLSKLILRH 385
Cdd:COG1150    1 NLKKCYQCGTCTASCPVARA------MDYNPRKI--IRLAQLGLKEEVlkSDSIWLCVSCYTCTERCPRGIDIADVMDAL 72


                 ....*..
gi 445946052 386 RRVMAEK 392
Cdd:COG1150   73 RNLAIRE 79
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 307-373 3.85e-07

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 46.86  E-value: 3.85e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 445946052  307 RDVLRCIRCGACMNTCPAYRHIGGHGYGSIYPGPIgavispllggykdfKDLPYACSLCTACDSVCP 373
Cdd:pfam13237   4 IDPDKCIGCGRCTAACPAGLTRVGAIVERLEGEAV--------------RIGVWKCIGCGACVEACP 56
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 311-374 6.02e-06

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 45.47  E-value: 6.02e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 445946052 311 RCIRCGACMNTCPayrhigghgYGSIYPGPIGAVISPLLggyKDFKdlpyACSLCTACDSVCPV 374
Cdd:cd10549    7 KCIGCGICVKACP---------TDAIELGPNGAIARGPE---IDED----KCVFCGACVEVCPT 54
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 311-373 1.23e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 45.32  E-value: 1.23e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 445946052 311 RCIRCGACMNTCPayrhigghgYGSIYPGPIGAVISPLLGGYKDFKDlpYACSLC-TACDSVCP 373
Cdd:cd16373   15 LCIRCGLCVEACP---------TGVIQPAGLEDGLEGGRTPYLDPRE--GPCDLCcDACVEVCP 67
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 311-374 1.45e-05

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 42.77  E-value: 1.45e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 445946052 311 RCIRCGACMNTCPAyrhigghgygsiypgpigAVISPLLGGYKDFKDLPYACSLCTACDSVCPV 374
Cdd:COG1146    9 KCIGCGACVEVCPV------------------DVLELDEEGKKALVINPEECIGCGACELVCPV 54
ACS_1 cd01916
Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and ...
 305-393 3.08e-05

Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH) consisting of two ACS and two CODH subunits. CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP). ACS has three structural domains, an N-terminal rossman fold domain with a helical region at its N-terminus which interacts with CODH, and two alpha + beta fold domains. A Ni-Fe-S center referred to as the A-cluster is located in the C-terminal domain. A large cavity exists between the three domains which may bind CoA.


Pssm-ID: 238897 [Multi-domain]  Cd Length: 731  Bit Score: 46.63  E-value: 3.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 305 EFRDVL-RCIRCGACMNTCPAYRHIGghgygsiypgpiGAVISPLLGGYKDFKDLPYACSLCTACDSVCPVRIPLSKLIL 383
Cdd:cd01916  359 EFQELAaKCTDCGWCTRACPNSLRIK------------EAMEAAKEGDFSGLADLFDQCVGCGRCEQECPKEIPIINMIE 426

                         90
                 ....*....|..
gi 445946052 384 R--HRRVMAEKG 393
Cdd:cd01916  427 KaaRERIKEEKG 438
Fer4_9 pfam13187
4Fe-4S dicluster domain;
311-373 3.19e-05

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 41.39  E-value: 3.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 445946052  311 RCIRCGACMNTCPAyrhigghgygsiypgpiGAVISPLLGGYKDFKDLPYACSLCTACDSVCP 373
Cdd:pfam13187   1 KCTGCGACVAACPA-----------------GAIVPDLVGQTIRGDIAGLACIGCGACVDACP 46
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 311-374 3.87e-05

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 41.95  E-value: 3.87e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 445946052 311 RCIRCGACMNTCPAyrhigghgyGSIYPGPIGAVISPLLggykdfkdlpyaCSLCTACDSVCPV 374
Cdd:COG4231   23 KCTGCGACVKVCPA---------DAIEEGDGKAVIDPDL------------CIGCGSCVQVCPV 65
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 308-374 5.68e-05

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 42.76  E-value: 5.68e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 445946052 308 DVLRCIRCGACMNTCPaYRHIGGHGYGSIYpgpigavISPLLGGYKDFKDLPYACSLCT--ACDSVCPV 374
Cdd:cd04410    4 DLDRCIGCGTCEVACK-QEHGLRPGPDWSR-------IKVIEGGGLERAFLPVSCMHCEdpPCVKACPT 64
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 311-374 1.20e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 40.10  E-value: 1.20e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 445946052 311 RCIRCGACMNTCPayrhigghgYGSIYPGPIGA-VISPLLggykdfkdlpyaCSLCTACDSVCPV 374
Cdd:COG1149   12 KCIGCGLCVEVCP---------EGAIKLDDGGApVVDPDL------------CTGCGACVGVCPT 55
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 312-376 1.33e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 39.43  E-value: 1.33e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 445946052  312 CIRCGACMNTCPayrhigghgYGSIYPGPIGAVispllGGYKDFKDLPYACSLCTACDSVCPVRI 376
Cdd:pfam12838   1 CIGCGACVAACP---------VGAITLDEVGEK-----KGTKTVVIDPERCVGCGACVAVCPTGA 51
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 311-374 2.40e-04

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 39.34  E-value: 2.40e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 445946052 311 RCIRCGACMNTCPAyrhigghgyGSIYPGPIGAVISPllggYKDFKDlpyaCSLCTACDSVCPV 374
Cdd:COG1143    3 KCIGCGLCVRVCPV---------DAITIEDGEPGKVY----VIDPDK----CIGCGLCVEVCPT 49
Fer4_16 pfam13484
4Fe-4S double cluster binding domain;
312-373 4.85e-04

4Fe-4S double cluster binding domain;


Pssm-ID: 463893 [Multi-domain]  Cd Length: 65  Bit Score: 38.24  E-value: 4.85e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 445946052  312 CIRCGACMNTCPAYrHIGGhGYGSIYPGPIgavISPLLGGYKDFKDLPYACSL------CTACDSVCP 373
Cdd:pfam13484   1 CGSCGKCIDACPTG-AIVG-PEGVLDARRC---ISYLTIEKKGLIPDELRCLLgnrcygCDICQDVCP 63
NapF COG1145
Ferredoxin [Energy production and conversion];
175-374 5.12e-04

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 41.63  E-value: 5.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 175 YEGPETPEAMTLFIRQKIREDFLSAEIGITGCNFAVAETGSVCLVTNEGNARMCTTLPKTHIAVMGMERIAPTFAEVDVL 254
Cdd:COG1145   60 DALKDVLGILGAIVIGIGAGEIVRVGIAAADLNLKAVALVLLLALAVAGAAKRLIISAVKLVAGLVVAAGEVLLVIAAAL 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 255 ITMLARSAVGARLTGYNTWLTGPREAGHVDGPEEFHLVIVDNGRsevlasefrdvlrCIRCGACMNTCPayrhigghgYG 334
Cdd:COG1145  140 AEAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAKAVIDAEK-------------CIGCGLCVKVCP---------TG 197

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 445946052 335 SIYPGPigavispllgGYKDFKDLPYACSLCTACDSVCPV 374
Cdd:COG1145  198 AIRLKD----------GKPQIVVDPDKCIGCGACVKVCPV 227
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 311-393 9.41e-04

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 40.21  E-value: 9.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445946052 311 RCIRCGACMNTCPayrhigghgYGSIYPGPIGAVISPLLGGYKdfKDLPYACSLC---------TACDSVCPV--RI--- 376
Cdd:cd10551   84 KCIGCRYCMAACP---------YGARYFNPEEPHEFGEVPVRP--KGVVEKCTFCyhrldegllPACVEACPTgaRIfgd 152

                         90       100
                 ....*....|....*....|....*
gi 445946052 377 ------PLSKLI--LRHRRVMAEKG 393
Cdd:cd10551  153 lddpnsEVSKLLaeRRAYVLKPELG 177
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 304-373 1.01e-03

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 39.53  E-value: 1.01e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 445946052 304 SEFRDvlRCIRCGACMNTCPayrhigghgygsiypgpiGAVISPLLGGYK--DFKDlpYACSLCTACDSVCP 373
Cdd:cd10564    9 ALFLD--LCTRCGDCVEACP------------------EGIIVRGDGGFPelDFSR--GECTFCGACAEACP 58
Fer4_2 pfam12797
4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to ...
 306-324 2.87e-03

4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 463711 [Multi-domain]  Cd Length: 22  Bit Score: 35.07  E-value: 2.87e-03
                          10
                  ....*....|....*....
gi 445946052  306 FRDVLRCIRCGACMNTCPA 324
Cdd:pfam12797   4 LIDADKCIGCGACVSACPA 22
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 309-373 3.66e-03

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 36.85  E-value: 3.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 445946052  309 VLRCIRCGACMNTCP-AYRHIGGHGYGSIypgpigavispllggykDFKDLPyaCSLCTACDSVCP 373
Cdd:TIGR00402  33 SAVCTRCGECASACEnNILQLGQQGQPTV-----------------EFDNAE--CDFCGKCAEACP 79
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
311-374 5.83e-03

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 35.48  E-value: 5.83e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 445946052 311 RCIRCGACMNTCPayrhigghgYGSIYPGPIGAVISPllggykdfkDLpyaCSLCTACDSVCPV 374
Cdd:COG2768   12 KCIGCGACVKVCP---------VGAISIEDGKAVIDP---------EK---CIGCGACIEVCPV 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH