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Conserved domains on  [gi|445951552|ref|WP_000029407|]
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MULTISPECIES: alpha/beta fold hydrolase [Bacillus]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 7-121 1.06e-25

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 100.85  E-value: 1.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552   7 GTLQVIGASIYYEVRG-SGPILLLIHGGGGDADKFHNIADHLAKWYTVVTYDRRGHSRSNLVnkNEDYHVHTHSEDAHRL 85
Cdd:COG0596    5 RFVTVDGVRLHYREAGpDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKP--AGGYTLDDLADDLAAL 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 445951552  86 LANLTKEPAYVFGSSSGAVIGLDLCIRHPEQVQLLI 121
Cdd:COG0596   83 LDALGLERVVLVGHSMGGMVALELAARHPERVAGLV 118
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 7-121 1.06e-25

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 100.85  E-value: 1.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552   7 GTLQVIGASIYYEVRG-SGPILLLIHGGGGDADKFHNIADHLAKWYTVVTYDRRGHSRSNLVnkNEDYHVHTHSEDAHRL 85
Cdd:COG0596    5 RFVTVDGVRLHYREAGpDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKP--AGGYTLDDLADDLAAL 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 445951552  86 LANLTKEPAYVFGSSSGAVIGLDLCIRHPEQVQLLI 121
Cdd:COG0596   83 LDALGLERVVLVGHSMGGMVALELAARHPERVAGLV 118
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 25-118 3.56e-15

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 72.92  E-value: 3.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552   25 PILLLIHGGGGDADKFHNIADHLAKW-YTVVTYDRRGHSRSNLVNKNEDYHVHTHSEDAHRLLANLTKEPAYVFGSSSGA 103
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDgFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90
                  ....*....|....*
gi 445951552  104 VIGLDLCIRHPEQVQ 118
Cdd:pfam00561  81 LIALAYAAKYPDRVK 95
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 13-118 2.04e-08

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 53.97  E-value: 2.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552  13 GASIYYEVRG-SGPILLLIHGGGGDADKFHNIADHLAKWYTVVTYDRRGHSRSNLVN-----KNEDYHVHTHSEDAHRLL 86
Cdd:PLN02824  17 GYNIRYQRAGtSGPALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYSDKPNprsapPNSFYTFETWGEQLNDFC 96

                         90       100       110
                 ....*....|....*....|....*....|..
gi 445951552  87 ANLTKEPAYVFGSSSGAVIGLDLCIRHPEQVQ 118
Cdd:PLN02824  97 SDVVGDPAFVICNSVGGVVGLQAAVDAPELVR 128
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 7-121 1.06e-25

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 100.85  E-value: 1.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552   7 GTLQVIGASIYYEVRG-SGPILLLIHGGGGDADKFHNIADHLAKWYTVVTYDRRGHSRSNLVnkNEDYHVHTHSEDAHRL 85
Cdd:COG0596    5 RFVTVDGVRLHYREAGpDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKP--AGGYTLDDLADDLAAL 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 445951552  86 LANLTKEPAYVFGSSSGAVIGLDLCIRHPEQVQLLI 121
Cdd:COG0596   83 LDALGLERVVLVGHSMGGMVALELAARHPERVAGLV 118
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 25-118 3.56e-15

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 72.92  E-value: 3.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552   25 PILLLIHGGGGDADKFHNIADHLAKW-YTVVTYDRRGHSRSNLVNKNEDYHVHTHSEDAHRLLANLTKEPAYVFGSSSGA 103
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDgFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90
                  ....*....|....*
gi 445951552  104 VIGLDLCIRHPEQVQ 118
Cdd:pfam00561  81 LIALAYAAKYPDRVK 95
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
13-121 1.13e-14

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 71.19  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552  13 GASIYYEV----RGSGPILLLIHGGGGDADKFHNIADHLAKW-YTVVTYDRRGHSRSnLVNKNEDYHVHTHSEDAHRLLA 87
Cdd:COG2267   13 GLRLRGRRwrpaGSPRGTVVLVHGLGEHSGRYAELAEALAAAgYAVLAFDLRGHGRS-DGPRGHVDSFDDYVDDLRAALD 91

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 445951552  88 NLTKEPA---YVFGSSSGAVIGLDLCIRHPEQVQLLI 121
Cdd:COG2267   92 ALRARPGlpvVLLGHSMGGLIALLYAARYPDRVAGLV 128
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 26-121 1.77e-11

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 62.23  E-value: 1.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552   26 ILLLIHGGGGDADKFHNIADHLAKW-YTVVTYDRRGHSRSnlvnknEDYHVHTHS-----EDAHRLLANLTKE----PAY 95
Cdd:pfam12146   6 VVVLVHGLGEHSGRYAHLADALAAQgFAVYAYDHRGHGRS------DGKRGHVPSfddyvDDLDTFVDKIREEhpglPLF 79

                          90       100
                  ....*....|....*....|....*.
gi 445951552   96 VFGSSSGAVIGLDLCIRHPEQVQLLI 121
Cdd:pfam12146  80 LLGHSMGGLIAALYALRYPDKVDGLI 105
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 13-118 2.04e-08

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 53.97  E-value: 2.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552  13 GASIYYEVRG-SGPILLLIHGGGGDADKFHNIADHLAKWYTVVTYDRRGHSRSNLVN-----KNEDYHVHTHSEDAHRLL 86
Cdd:PLN02824  17 GYNIRYQRAGtSGPALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYSDKPNprsapPNSFYTFETWGEQLNDFC 96

                         90       100       110
                 ....*....|....*....|....*....|..
gi 445951552  87 ANLTKEPAYVFGSSSGAVIGLDLCIRHPEQVQ 118
Cdd:PLN02824  97 SDVVGDPAFVICNSVGGVVGLQAAVDAPELVR 128
PLN02578 PLN02578
hydrolase
 13-117 2.62e-07

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 50.99  E-value: 2.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552  13 GASIYYEVRGSGPILLLIHGGGgdADKFH---NIADhLAKWYTVVTYDRRGHSRSN--LVnkneDYHVHTHSEDAHRLLA 87
Cdd:PLN02578  75 GHKIHYVVQGEGLPIVLIHGFG--ASAFHwryNIPE-LAKKYKVYALDLLGFGWSDkaLI----EYDAMVWRDQVADFVK 147

                         90       100       110
                 ....*....|....*....|....*....|
gi 445951552  88 NLTKEPAYVFGSSSGAVIGLDLCIRHPEQV 117
Cdd:PLN02578 148 EVVKEPAVLVGNSLGGFTALSTAVGYPELV 177
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 27-109 2.75e-06

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 47.08  E-value: 2.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552   27 LLLIHGGGGDADKFhniADHLAKWYTVVTYDRRGHSRSnlvnkNEDYHVHTHSEDAHRLLANL-TKEPAYVFGSSSGAVI 105
Cdd:pfam12697   1 VVLVHGAGLSAAPL---AALLAAGVAVLAPDLPGHGSS-----SPPPLDLADLADLAALLDELgAARPVVLVGHSLGGAV 72


                  ....
gi 445951552  106 GLDL 109
Cdd:pfam12697  73 ALAA 76
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
25-126 6.27e-06

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 46.16  E-value: 6.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552  25 PILLLIHGGGGDADK-FHNIADHLAKW-YTVVTYDRRGHSRSNLVNKNEDYhvhthsEDAHRLLANLTKEPA------YV 96
Cdd:COG1506   24 PVVVYVHGGPGSRDDsFLPLAQALASRgYAVLAPDYRGYGESAGDWGGDEV------DDVLAAIDYLAARPYvdpdriGI 97

                         90       100       110
                 ....*....|....*....|....*....|
gi 445951552  97 FGSSSGAVIGLDLCIRHPEQVQLLIPHEPV 126
Cdd:COG1506   98 YGHSYGGYMALLAAARHPDRFKAAVALAGV 127
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
15-121 1.34e-05

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 45.39  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552  15 SIYYEVRGSGPI-LLLIHGGGGDADKFHNIADHLAKWYTVVTYDRRGHSRSNlvnkneDYHVHTHSEDAHRLLANlTKEP 93
Cdd:PRK10349   3 NIWWQTKGQGNVhLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSR------GFGALSLADMAEAVLQQ-APDK 75

                         90       100
                 ....*....|....*....|....*...
gi 445951552  94 AYVFGSSSGAVIGLDLCIRHPEQVQLLI 121
Cdd:PRK10349  76 AIWLGWSLGGLVASQIALTHPERVQALV 103
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
21-115 2.02e-05

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 44.55  E-value: 2.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552  21 RGSGPILLLIHGGGGDADKFHNIADHLAKW-YTVVTYDRRGHSRSnlvnKNEDYHVHTHS--EDAHRLLANLTK--EPAY 95
Cdd:COG1647   12 EGGRKGVLLLHGFTGSPAEMRPLAEALAKAgYTVYAPRLPGHGTS----PEDLLKTTWEDwlEDVEEAYEILKAgyDKVI 87

                         90       100
                 ....*....|....*....|
gi 445951552  96 VFGSSSGAVIGLDLCIRHPE 115
Cdd:COG1647   88 VIGLSMGGLLALLLAARYPD 107
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 10-117 9.99e-05

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 43.01  E-value: 9.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552  10 QVIGASIYYEVRG--SGPILLLIHGGGGDADKF-HNIADhLAKWYTVVTYDRRGHSRSNLVnknedyhVHTHSEDA---- 82
Cdd:PRK14875 115 RIGGRTVRYLRLGegDGTPVVLIHGFGGDLNNWlFNHAA-LAAGRPVIALDLPGHGASSKA-------VGAGSLDElaaa 186

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 445951552  83 -HRLLANLTKEPAYVFGSSSGAVIGLDLCIRHPEQV 117
Cdd:PRK14875 187 vLAFLDALGIERAHLVGHSMGGAVALRLAARAPQRV 222
PRK05855 PRK05855
SDR family oxidoreductase;
13-64 1.06e-04

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 43.43  E-value: 1.06e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 445951552  13 GASIYYEVRG--SGPILLLIHGGGGDADKFHNIADHLAKWYTVVTYDRRGHSRS 64
Cdd:PRK05855  12 GVRLAVYEWGdpDRPTVVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRS 65
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 8-127 1.61e-03

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 39.21  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552   8 TLQVIGASIYYEVRGSGPILLLIHGGGGDADKFHNIADHLAKWYTVVTYDRRGHSRSNlvNKNEDYHVHTHSE--DAhrL 85
Cdd:PRK03592  11 RVEVLGSRMAYIETGEGDPIVFLHGNPTSSYLWRNIIPHLAGLGRCLAPDLIGMGASD--KPDIDYTFADHARylDA--W 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 445951552  86 LANLTKEPAYVFGSSSGAVIGLDLCIRHPEQVQLLIPHEPVL 127
Cdd:PRK03592  87 FDALGLDDVVLVGHDWGSALGFDWAARHPDRVRGIAFMEAIV 128
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
16-127 6.01e-03

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 37.16  E-value: 6.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445951552  16 IYY--EVRGSGPILLLIHGGG---GDADKFHNIADHLAKW--YTVVTYD-RRGHsrsnlvnkneDYHVHTHSEDAHRLLA 87
Cdd:COG0657    3 VYRpaGAKGPLPVVVYFHGGGwvsGSKDTHDPLARRLAARagAAVVSVDyRLAP----------EHPFPAALEDAYAALR 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 445951552  88 NLTKEPA---------YVFGSSSG----AVIGLDLCIRHPEQVQLLIPHEPVL 127
Cdd:COG0657   73 WLRANAAelgidpdriAVAGDSAGghlaAALALRARDRGGPRPAAQVLIYPVL 125
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
14-54 6.30e-03

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 37.39  E-value: 6.30e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 445951552  14 ASIYY--------EVRGSGPILLLIHGGGGDADKFHNIADHLAKW-YTVV 54
Cdd:COG4188   44 VDVWYpatapadaPAGGPFPLVVLSHGLGGSREGYAYLAEHLASHgYVVA 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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