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Conserved domains on  [gi|445972468|ref|WP_000050323|]
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MULTISPECIES: citrate/succinate antiporter CitT [Enterobacteriaceae]

Protein Classification

anion permease( domain architecture ID 10469635)

anion permease translocates charged substrates such as sodium, arsenate, antimonite, sulfate and organic anions across biological membranes; similar to Eschericha coli L-tartrate/succinate antiporter

Gene Ontology:  GO:0022857|GO:0005886
TCDB:  2.A.47

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
5-486 0e+00

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


:

Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 559.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468    5 KDNIWKLLAPLVVMGVMFLIPVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLfdakeladpa 84
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLL---------- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468   85 fnaqKQALKWGLAGFSSTTVWLVFGAFIFALGYEVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTG 164
Cdd:pfam00939  71 ----AKALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRTLGLGYGLVFSDLLLAPATPSNTARAG 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  165 GTVFPVIKNLPPLFKSFPNDPSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGIQISWLQWFLCFLPVG 244
Cdd:pfam00939 147 GIVFPIIMSLPPAFGSDPEKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVTITWASWFLAAIPPG 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  245 VILLIIAPWLSYVLYKPEITHSEEVATWAGDELKTMGALTRREWTLIGLVLLSLGLWVFGSEV-INATAVGLLAVSLMLA 323
Cdd:pfam00939 227 VILLLLAPLLLYVLYPPEIKSVPDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGGSLnIDATTVAIIGLALMLL 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  324 LHVVPWKDITRYNSAWNTLVNLATLVVMANGLTRSGFIDWFAGTMSTHLEGFSPNATVIVLVLVFYFAHYLFASLSAHTA 403
Cdd:pfam00939 307 LRILDWKDIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMAFIIILSLFYLSHYLFASATAHTA 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  404 TMLPVILAVGKGIPGVPMEQLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYISMLLLVG---W 480
Cdd:pfam00939 387 AMLPIFAAVAQAIPGAPPLLAALLLGFAISLGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGnwwW 466

                  ....*.
gi 445972468  481 PILAMW 486
Cdd:pfam00939 467 KPLGSL 472
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
5-486 0e+00

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 559.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468    5 KDNIWKLLAPLVVMGVMFLIPVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLfdakeladpa 84
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLL---------- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468   85 fnaqKQALKWGLAGFSSTTVWLVFGAFIFALGYEVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTG 164
Cdd:pfam00939  71 ----AKALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRTLGLGYGLVFSDLLLAPATPSNTARAG 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  165 GTVFPVIKNLPPLFKSFPNDPSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGIQISWLQWFLCFLPVG 244
Cdd:pfam00939 147 GIVFPIIMSLPPAFGSDPEKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVTITWASWFLAAIPPG 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  245 VILLIIAPWLSYVLYKPEITHSEEVATWAGDELKTMGALTRREWTLIGLVLLSLGLWVFGSEV-INATAVGLLAVSLMLA 323
Cdd:pfam00939 227 VILLLLAPLLLYVLYPPEIKSVPDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGGSLnIDATTVAIIGLALMLL 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  324 LHVVPWKDITRYNSAWNTLVNLATLVVMANGLTRSGFIDWFAGTMSTHLEGFSPNATVIVLVLVFYFAHYLFASLSAHTA 403
Cdd:pfam00939 307 LRILDWKDIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMAFIIILSLFYLSHYLFASATAHTA 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  404 TMLPVILAVGKGIPGVPMEQLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYISMLLLVG---W 480
Cdd:pfam00939 387 AMLPIFAAVAQAIPGAPPLLAALLLGFAISLGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGnwwW 466

                  ....*.
gi 445972468  481 PILAMW 486
Cdd:pfam00939 467 KPLGSL 472
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
25-479 3.49e-170

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 486.85  E-value: 3.49e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468   25 PVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLFDAKELAdpafnaqkqalkwgLAGFSSTTV 104
Cdd:TIGR00785   1 PVPDGLNSGAWLLLAIFVAAIVGWILEPLPLPVTALLAIPIIAVLLGVLSAFKFKNA--------------LSGFADPTI 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  105 WLVFGAFIFALGYEVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTGGTVFPVIKNLPPLFKSFPnD 184
Cdd:TIGR00785  67 WLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTARAGGILLPIIKSLLPLLGSKP-E 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  185 PSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGIQISWLQWFLCFLPVGVILLIIAPWLSYVLYKPEIT 264
Cdd:TIGR00785 146 KSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGILSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELK 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  265 HSEEVATWAGDELKTMGALTRREWTLIGLVLLSLGLWVFG-SEVINATAVGLLAVSLMLALHVVPWKDITRYNSAWNTLV 343
Cdd:TIGR00785 226 LKDEVDLWAKEELEEMGPMSFREKALLGIFLLALLLWIFGgSLGINASVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLI 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  344 NLATLVVMANGLTRSGFIDWFAGTMSTHLEGFSPNATVIVLVLVFYFAHYLFASLSAHTATMLPVILAVGKgIPGVPMEQ 423
Cdd:TIGR00785 306 LFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVAS-AQGIPLEL 384
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 445972468  424 LCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYISMLLLVG 479
Cdd:TIGR00785 385 LALALALSASLMGFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVG 440
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
108-485 1.28e-80

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 255.08  E-value: 1.28e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 108 FGAFIFALGYEVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTpSNTARTGgTVFPVIKNLPPLFKSFPNdpsa 187
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFI-SNTARAA-MMLPIALSIAAALGSEKR---- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 188 RRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGIQISWLQWFLCFLPVGVILLIIAPWLSYVLYKPEITHSE 267
Cdd:COG0471   75 SKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 268 EVATWAGDELKTMGALTRREWTLIGLVLLSLGLWVFGSEV-INATAVGLLAVSLMLALHVVPWKDITRyNSAWNTLVNLA 346
Cdd:COG0471  155 GSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHgIPIAVVALLGAVLLLLTGVLTWKDAYK-SIPWGVLLLFG 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 347 TLVVMANGLTRSGFIDWFAGTMSTHLEGFSPNATVIVLVLVFYFaHYLFASLSAHTATMLPVILAVGKGIpGVPMEQLCI 426
Cdd:COG0471  234 GGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLL-LTEFASNTATAALLLPIAISLAQAL-GVNPLPLAL 311
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 445972468 427 LLVLSIGiMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYISMLLLVGWPILAM 485
Cdd:COG0471  312 AVAFAAS-CAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
92-483 5.78e-33

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 129.29  E-value: 5.78e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  92 LKWGLAGFSSTTVWLVFGAFIFALGYEVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFtpSNTARTGGTVFPVI 171
Cdd:cd00625   30 PKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLLLMLLTAALSAFF--SNDATAVLLTPIVL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 172 KNLPPLFKSFPNdpsarriggYLMWMMVISTSLSSSMFVTGAAPNVLglefVSKIAGIQISWLQWFlCFLPVGVILLIIA 251
Cdd:cd00625  108 ALLRKLGLSPPV---------PLLLALAFAANIGGAATPIGNPPNLI----IASLSGLGFLDFLAF-MAPPALGLLLLLL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 252 PWLSYVLYKPEITHSEEVATWAGDELKTMGALTRREWTLIGLVLLSLGLWVFGSEVINATAVGLLAVsLMLALHVVPWKD 331
Cdd:cd00625  174 GLLYLLFRKKLLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLIALLGALLL-LLLLVRGLDPEE 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 332 ITRyNSAWNTLVNLATLVVMANGLTRSGFIDWFAGTMSTHLEGFSPNATVIVLVLVFYFAhyLFASLSAHTATMLPVILA 411
Cdd:cd00625  253 VLK-SVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLS--NFISNVPTVALLLPIAAS 329
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 445972468 412 VGkgipgvPMEQLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDY-WRLGAIFGVIYISMLLLVGWPIL 483
Cdd:cd00625  330 LA------PPEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGIsFGEFLKVGLPLTLLSLVVSLLYL 396
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
5-486 0e+00

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 559.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468    5 KDNIWKLLAPLVVMGVMFLIPVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLfdakeladpa 84
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLL---------- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468   85 fnaqKQALKWGLAGFSSTTVWLVFGAFIFALGYEVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTG 164
Cdd:pfam00939  71 ----AKALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRTLGLGYGLVFSDLLLAPATPSNTARAG 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  165 GTVFPVIKNLPPLFKSFPNDPSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGIQISWLQWFLCFLPVG 244
Cdd:pfam00939 147 GIVFPIIMSLPPAFGSDPEKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVTITWASWFLAAIPPG 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  245 VILLIIAPWLSYVLYKPEITHSEEVATWAGDELKTMGALTRREWTLIGLVLLSLGLWVFGSEV-INATAVGLLAVSLMLA 323
Cdd:pfam00939 227 VILLLLAPLLLYVLYPPEIKSVPDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGGSLnIDATTVAIIGLALMLL 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  324 LHVVPWKDITRYNSAWNTLVNLATLVVMANGLTRSGFIDWFAGTMSTHLEGFSPNATVIVLVLVFYFAHYLFASLSAHTA 403
Cdd:pfam00939 307 LRILDWKDIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMAFIIILSLFYLSHYLFASATAHTA 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  404 TMLPVILAVGKGIPGVPMEQLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYISMLLLVG---W 480
Cdd:pfam00939 387 AMLPIFAAVAQAIPGAPPLLAALLLGFAISLGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGnwwW 466

                  ....*.
gi 445972468  481 PILAMW 486
Cdd:pfam00939 467 KPLGSL 472
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
25-479 3.49e-170

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 486.85  E-value: 3.49e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468   25 PVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLFDAKELAdpafnaqkqalkwgLAGFSSTTV 104
Cdd:TIGR00785   1 PVPDGLNSGAWLLLAIFVAAIVGWILEPLPLPVTALLAIPIIAVLLGVLSAFKFKNA--------------LSGFADPTI 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  105 WLVFGAFIFALGYEVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTGGTVFPVIKNLPPLFKSFPnD 184
Cdd:TIGR00785  67 WLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTARAGGILLPIIKSLLPLLGSKP-E 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  185 PSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGIQISWLQWFLCFLPVGVILLIIAPWLSYVLYKPEIT 264
Cdd:TIGR00785 146 KSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGILSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELK 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  265 HSEEVATWAGDELKTMGALTRREWTLIGLVLLSLGLWVFG-SEVINATAVGLLAVSLMLALHVVPWKDITRYNSAWNTLV 343
Cdd:TIGR00785 226 LKDEVDLWAKEELEEMGPMSFREKALLGIFLLALLLWIFGgSLGINASVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLI 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  344 NLATLVVMANGLTRSGFIDWFAGTMSTHLEGFSPNATVIVLVLVFYFAHYLFASLSAHTATMLPVILAVGKgIPGVPMEQ 423
Cdd:TIGR00785 306 LFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVAS-AQGIPLEL 384
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 445972468  424 LCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYISMLLLVG 479
Cdd:TIGR00785 385 LALALALSASLMGFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVG 440
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
108-485 1.28e-80

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 255.08  E-value: 1.28e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 108 FGAFIFALGYEVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTpSNTARTGgTVFPVIKNLPPLFKSFPNdpsa 187
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFI-SNTARAA-MMLPIALSIAAALGSEKR---- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 188 RRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGIQISWLQWFLCFLPVGVILLIIAPWLSYVLYKPEITHSE 267
Cdd:COG0471   75 SKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 268 EVATWAGDELKTMGALTRREWTLIGLVLLSLGLWVFGSEV-INATAVGLLAVSLMLALHVVPWKDITRyNSAWNTLVNLA 346
Cdd:COG0471  155 GSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHgIPIAVVALLGAVLLLLTGVLTWKDAYK-SIPWGVLLLFG 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 347 TLVVMANGLTRSGFIDWFAGTMSTHLEGFSPNATVIVLVLVFYFaHYLFASLSAHTATMLPVILAVGKGIpGVPMEQLCI 426
Cdd:COG0471  234 GGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLL-LTEFASNTATAALLLPIAISLAQAL-GVNPLPLAL 311
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 445972468 427 LLVLSIGiMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYISMLLLVGWPILAM 485
Cdd:COG0471  312 AVAFAAS-CAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
92-483 5.78e-33

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 129.29  E-value: 5.78e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  92 LKWGLAGFSSTTVWLVFGAFIFALGYEVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFtpSNTARTGGTVFPVI 171
Cdd:cd00625   30 PKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLLLMLLTAALSAFF--SNDATAVLLTPIVL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 172 KNLPPLFKSFPNdpsarriggYLMWMMVISTSLSSSMFVTGAAPNVLglefVSKIAGIQISWLQWFlCFLPVGVILLIIA 251
Cdd:cd00625  108 ALLRKLGLSPPV---------PLLLALAFAANIGGAATPIGNPPNLI----IASLSGLGFLDFLAF-MAPPALGLLLLLL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 252 PWLSYVLYKPEITHSEEVATWAGDELKTMGALTRREWTLIGLVLLSLGLWVFGSEVINATAVGLLAVsLMLALHVVPWKD 331
Cdd:cd00625  174 GLLYLLFRKKLLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLIALLGALLL-LLLLVRGLDPEE 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 332 ITRyNSAWNTLVNLATLVVMANGLTRSGFIDWFAGTMSTHLEGFSPNATVIVLVLVFYFAhyLFASLSAHTATMLPVILA 411
Cdd:cd00625  253 VLK-SVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLS--NFISNVPTVALLLPIAAS 329
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 445972468 412 VGkgipgvPMEQLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDY-WRLGAIFGVIYISMLLLVGWPIL 483
Cdd:cd00625  330 LA------PPEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGIsFGEFLKVGLPLTLLSLVVSLLYL 396
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
38-486 2.06e-16

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 80.71  E-value: 2.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  38 FAVFVAMIVGMILEPIPATAISFIAVTICVIGSnylLFDAKELadpafnaqkqalkwgLAGFSSTTVWLVFGAFIFALGY 117
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLG---VVPPKEA---------------FSGFSDPAVILFLAGFILGAAL 62
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 118 EVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTpSNTArTGGTVFPVIKnlpPLFKSFPNDPSArriggyLMWM 197
Cdd:cd01115   63 TRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFM-SNTA-TVAIMLPVAL---GLAAKLDISPSR------LLMP 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 198 MVISTSLSSSMFVTGAAPNVLGLEFVSKIAGiqisWLQWFLCFLPVGVILLIIApwlsyVLYKpeithseevatwagdel 277
Cdd:cd01115  132 LAFAASIGGMLTLIGTPPNLVASGYLESLGG----QGFSFFEFTPIGLPLLIIG-----LLYL----------------- 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 278 ktmgALTRREWTLIGLVLLSLGLwVFGSEVINATAVGLLAVSLMLALHVVPWKDItrYNS-AWNTLVNLATLVVMANGLT 356
Cdd:cd01115  186 ----WFIFRLAVLIITIVLLAAL-AAITGLLPVSVAIAIGAIVLVFGGVLLTKED--YKSiDWGIIFLFAGGIPLGKALE 258
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 357 RSGFIDWFAGTMSTHLEGFSPnatvIVLVLVFYFAHYLFASLSAHTAT---MLPVILAVGKGIPGVPmeqlcILLVLSIG 433
Cdd:cd01115  259 SSGAAALIAEALISLLGGLPP----FAILLLLCLLTLVLTNFISNTATavlLAPIALSIALSLGLPP-----EALLLAVA 329
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 445972468 434 I---MGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIyisMLLLVGWPILAMW 486
Cdd:cd01115  330 IgasCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSIL---SLVVSVTMIPLIW 382
CitMHS pfam03600
Citrate transporter;
92-433 3.42e-10

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 61.56  E-value: 3.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468   92 LKWGLAGFSSTTVWLVFGAFIFALGYEVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFtPSNTArTGGTVFPVI 171
Cdd:pfam03600  30 PEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAF-LSNDG-TVLIMIPIV 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  172 KnlpPLFKSFPNDPSArriggyLMWMMVISTSLSSSMFVTGAAPNVLgLEFVSKIAGIQISWLQWFLCFLPVGVILLIIA 251
Cdd:pfam03600 108 L---ALARRLGLPPSP------LLIALAFAANIGGTATPIGDPPNII-IASALGLSFGDFGFFMFPPVGVALLLVGLLPL 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  252 PWLSYVLYKPEITHSEEVATWAGDelktmgalTRREWTLIGLVLLSLGLWVFGseVINATAVGLLAVSLMLALHVVPWKD 331
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKR--------AIKDKLLLAISALVLALVILG--FLLLSVLALAGALLLLLTGVLDPEE 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  332 ITRYNSaWNTLVNLATLVVMANGLTRSGFIDWFAGTMsthlEGFSPNATVIVLVLVFYFAHYLFASLSAHTATMLPVILA 411
Cdd:pfam03600 248 ALKAVD-WSTLLFFAGLFILVGALEKTGLADALADAL----GGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVG 322
                         330       340
                  ....*....|....*....|..
gi 445972468  412 VGKGIPGVPMEQLciLLVLSIG 433
Cdd:pfam03600 323 MAPAAGLGDPDPL--AWALAVG 342
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
300-478 9.51e-07

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 51.10  E-value: 9.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 300 LWVFGSEVINATAVGLLAVSLMLALHVVPWKDITRYNSaWNTLVNLATLVVMANGLTRSGFIDWFAGTMSTHLEGFSPNA 379
Cdd:cd00625    1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAID-WETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 380 TVIVLVLVFYFAhylFASLSAHTATMLPVILAVGKGIPGVPMEQLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKD 459
Cdd:cd00625   80 LLLMLLTAALSA---FFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIGGAATPIGNPPNLIIASLSGLGFLD 156
                        170
                 ....*....|....*....
gi 445972468 460 YWRLGAIFGVIYISMLLLV 478
Cdd:cd00625  157 FLAFMAPPALGLLLLLLGL 175
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
39-451 1.04e-05

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 47.82  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  39 AVFVAMIVGMILEP--IPATAISFIAVTICVIGSNYLLFDAkeladpafnaqkqalkwgLAGFSSTTVWLVFGAFIFALG 116
Cdd:COG1055    7 AIFVLTYLLIILEPrgLNRAVAALLGAALLLLLGVVSLEDA------------------LEAIDWNTILFLLGMMIIVAI 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 117 YEVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTGGT--VFPVIKNLPplFKSFPndpsarriggYL 194
Cdd:COG1055   69 LDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTpvVLAIARRLG--LNPVP----------FL 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 195 MwMMVISTSLSSSMFVTGAAPNVLglefvskIAGI-QISWLQWFLCFLPVGVILLIIAPWLSYVLYKPEITHSEEVATWA 273
Cdd:COG1055  137 I-AIVFAANIGGAATPIGNPTNIM-------IASAgGLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPDLEDDP 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 274 GDELKTMGALTrreWTLIGLVLLSLGLWVFGSEVINATAVGLLAVSLMLALHVVPWKDITRyNSAWNTLVNLATLVVMAN 353
Cdd:COG1055  209 KEAIKDRRLLR---ISLLVLALLLVGFVLHSFLGLPPALIALLGAAVLLLLARVDVREVLK-KVDWSTLLFFIGLFVVVG 284
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 354 GLTRSGFIDWFAGTMSTHLEGFSPNATVIVLVLVfyfahylfASLSA------HTATMLPVILAVGkgiPGVPMEQLCIL 427
Cdd:COG1055  285 GLENTGLLDLLAELLASLTGGNLLLAALLILWLS--------AILSAvvdnvpLVAALLPLIPDLG---ATGNPEPLWLA 353
                        410       420
                 ....*....|....*....|....
gi 445972468 428 LVLSIGIMGCLTPYATGPGVIIYG 451
Cdd:COG1055  354 LALGATLGGNLTPIGSAANVIVLG 377
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
287-440 1.52e-03

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 40.88  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468 287 EWTLIGLVLLSLGLWVFGSEVINATAVGLLAVSLMLALHVVPWKDITRYnSAWNTLVNLATLVVMANGLTRSGFIDWFAG 366
Cdd:COG1055    2 MILALAIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEA-IDWNTILFLLGMMIIVAILDESGFFEWLAI 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 445972468 367 TMSThLEGFSPNATVIVLVLVFYFAHYLFASLSAhTATMLPVILAVGK--GIPGVPMeqlCILLVLSIGIMGCLTP 440
Cdd:COG1055   81 KLAR-RAKGSPRRLLWLLGLLTALLSAFLDNDTT-ALLLTPVVLAIARrlGLNPVPF---LIAIVFAANIGGAATP 151
CitMHS pfam03600
Citrate transporter;
303-449 2.16e-03

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 40.37  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445972468  303 FGSEVINATAVGLLAVSLMLALHVVPWKDITRYnSAWNTLVNLATLVVMANGLTRSGFIDWFAGTMSTHLEGFSPNATVI 382
Cdd:pfam03600   4 IITEKLPRDVVALLGAVLLVLLGVLTPEEALSG-IDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVA 82
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 445972468  383 VLVLVFYFAhyLFASLSAHTATMLPVILAVGKgIPGVPMEQLCILLVLSIGIMGCLTPYATGPGVII 449
Cdd:pfam03600  83 LMLATALLS--AFLSNDGTVLIMIPIVLALAR-RLGLPPSPLLIALAFAANIGGTATPIGDPPNIII 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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