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Conserved domains on  [gi|445981242|ref|WP_000059097|]
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MULTISPECIES: chromosomal replication initiator protein DnaA [Escherichia]

Protein Classification

chromosomal replication initiator protein DnaA( domain architecture ID 11489097)

chromosomal replication initiator protein DnaA plays a key role in the initiation and regulation of chromosomal replication

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
6-464 0e+00

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


:

Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 720.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242    6 WQQCLARLQDELPATEFSMWIRPLQA-ELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTSFCGADaPQLRFEVGTKPVT 84
Cdd:TIGR00362   1 WNRILERLEKELSEQEYNTWFKPLKLlSIEGNTLIISVPNEFVKEWIEKNYLDLIEELLQELFGAE-IEIEFTVGEDEEE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242   85 QtlkAAASNTVAPAqaaqvqpqraapstrsgwdNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAY 164
Cdd:TIGR00362  80 L---EPNSKKPEPA-------------------PPEAPAPPSSASGLNPKYTFDNFVVGKSNRLAHAAALAVAENPGKAY 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  165 NPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKER 244
Cdd:TIGR00362 138 NPLFIYGGVGLGKTHLLHAIGNEILENNPNAKVLYVSSEKFTNDFVNALRNNKMEEFKEKYRSVDLLLIDDIQFLAGKER 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  245 SQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFI 324
Cdd:TIGR00362 218 TQEEFFHTFNALHENNKQIVLTSDRPPKELPGLEDRLRSRFEWGLVVDIEPPDLETRLAILQKKAEEEGLELPDEVLEFI 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  325 AKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVAR 404
Cdd:TIGR00362 298 AKNITSNVRELEGALNRLLAYASLTGKPITLELAKEALKDLLRAQKKEITIENIQKVVAKYYNIKVSDLKSKKRTRNIVR 377
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  405 PRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTL 464
Cdd:TIGR00362 378 PRQIAMYLAKELTDLSLPEIGKAFGGRDHTTVLHAVRKIEKLIETDAELKEDIEELKRKL 437
 
Name Accession Description Interval E-value
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
6-464 0e+00

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 720.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242    6 WQQCLARLQDELPATEFSMWIRPLQA-ELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTSFCGADaPQLRFEVGTKPVT 84
Cdd:TIGR00362   1 WNRILERLEKELSEQEYNTWFKPLKLlSIEGNTLIISVPNEFVKEWIEKNYLDLIEELLQELFGAE-IEIEFTVGEDEEE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242   85 QtlkAAASNTVAPAqaaqvqpqraapstrsgwdNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAY 164
Cdd:TIGR00362  80 L---EPNSKKPEPA-------------------PPEAPAPPSSASGLNPKYTFDNFVVGKSNRLAHAAALAVAENPGKAY 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  165 NPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKER 244
Cdd:TIGR00362 138 NPLFIYGGVGLGKTHLLHAIGNEILENNPNAKVLYVSSEKFTNDFVNALRNNKMEEFKEKYRSVDLLLIDDIQFLAGKER 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  245 SQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFI 324
Cdd:TIGR00362 218 TQEEFFHTFNALHENNKQIVLTSDRPPKELPGLEDRLRSRFEWGLVVDIEPPDLETRLAILQKKAEEEGLELPDEVLEFI 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  325 AKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVAR 404
Cdd:TIGR00362 298 AKNITSNVRELEGALNRLLAYASLTGKPITLELAKEALKDLLRAQKKEITIENIQKVVAKYYNIKVSDLKSKKRTRNIVR 377
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  405 PRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTL 464
Cdd:TIGR00362 378 PRQIAMYLAKELTDLSLPEIGKAFGGRDHTTVLHAVRKIEKLIETDAELKEDIEELKRKL 437
dnaA PRK00149
chromosomal replication initiator protein DnaA;
1-466 0e+00

chromosomal replication initiator protein DnaA;


Pssm-ID: 234667 [Multi-domain]  Cd Length: 401  Bit Score: 711.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242   1 MSLSLWQQCLARLQDELPATEFSMWIRPLQ-AELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTsfcgadapqlrfevg 79
Cdd:PRK00149   1 NLQSLWEKVLERLKDELSEQEYETWIKPLKaLSLEDNTLTLYVPNRFVKDWIEKNYLDLIEEALQ--------------- 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  80 tkpvtqtlkaaasntvapaqaaqvqpqraapstrsgwdnvpapaeptyrsnVNVKHTFDNFVEGKSNQLARAAARQVADN 159
Cdd:PRK00149  66 ---------------------------------------------------LNPKYTFDNFVVGKSNRLAHAAALAVAEN 94
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 160 PGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFF 239
Cdd:PRK00149  95 PGKAYNPLFIYGGVGLGKTHLLHAIGNYILEKNPNAKVVYVTSEKFTNDFVNALRNNTMEEFKEKYRSVDVLLIDDIQFL 174
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 240 ANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGE 319
Cdd:PRK00149 175 AGKERTQEEFFHTFNALHEAGKQIVLTSDRPPKELPGLEERLRSRFEWGLTVDIEPPDLETRIAILKKKAEEEGIDLPDE 254
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 320 VAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRS 399
Cdd:PRK00149 255 VLEFIAKNITSNVRELEGALNRLIAYASLTGKPITLELAKEALKDLLAAQKKKITIENIQKVVAEYYNIKVSDLKSKSRT 334
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 445981242 400 RSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS 466
Cdd:PRK00149 335 RNIARPRQIAMYLAKELTDLSLPEIGRAFGGRDHTTVLHAVRKIEKLLEEDPELKEDVEELKRKLKS 401
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
132-433 0e+00

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 550.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 132 NVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVK 211
Cdd:COG0593    2 NPRYTFDNFVVGPSNRLAHAAALAVAEWPGKAYNPLFLYGGVGLGKTHLLHAIGNEALENNPGARVVYLTAEEFTNDFIN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 212 ALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTV 291
Cdd:COG0593   82 AIRNNTIEEFKEKYRSVDVLLIDDIQFLAGKEATQEEFFHTFNALREAGKQIVLTSDRPPKELPGLEERLRSRLEWGLVV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 292 AIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEK 371
Cdd:COG0593  162 DIQPPDLETRIAILRKKAADRGLELPDEVLEYLARRIERNVRELEGALNRLDAYALLTGRPITLELAREVLKDLLRAQKK 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 445981242 372 LVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDH 433
Cdd:COG0593  242 EITIEDIQKAVAEYFGVSVADLLSKSRTREIARPRQIAMYLARELTDLSLPEIGRAFGGRDH 303
Bac_DnaA pfam00308
Bacterial dnaA protein;
132-349 1.28e-128

Bacterial dnaA protein;


Pssm-ID: 278724 [Multi-domain]  Cd Length: 219  Bit Score: 371.66  E-value: 1.28e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  132 NVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVK 211
Cdd:pfam00308   2 NPRYTFENFVIGPSNRFAHAAALTVAKAPGKAYNPLFIYGGVGLGKTHLLHAIGNYALQNAPNLRVVYLTAEEFLNDFVD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  212 ALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTV 291
Cdd:pfam00308  82 AIRDNKTNQFKEKYRNVDVLLIDDIQFLAGKEGTQEEFFHTFNALHESGKQIVFSSDRPPKELEELEDRLRSRFQWGLVT 161
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 445981242  292 AIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFT 349
Cdd:pfam00308 162 DIEPPDLETRLAILRKKAEAEGIEIPPEVLNFIAQRVTDNVRELEGALNRLLAYSSLN 219
Bac_DnaA_C cd06571
C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA ...
375-464 9.25e-44

C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple copies of DnaA, which is an ATPase, bind to 9-mers at the origin and form an initial complex in which the DNA strands are being separated in an ATP-dependent step.


Pssm-ID: 119330 [Multi-domain]  Cd Length: 90  Bit Score: 148.82  E-value: 9.25e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 375 IDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIK 454
Cdd:cd06571    1 IELIIEAVAEYFGISVEDLRSKSRKKEIALARQIAMYLARELTGLSLPEIGRAFGGRDHSTVLHAVRKIEELLEEDPELK 80
                         90
                 ....*....|
gi 445981242 455 EDFSNLIRTL 464
Cdd:cd06571   81 EDVEELEKKL 90
Bac_DnaA_C smart00760
Bacterial dnaA protein helix-turn-helix domain; Could be involved in DNA-binding.
374-442 1.09e-37

Bacterial dnaA protein helix-turn-helix domain; Could be involved in DNA-binding.


Pssm-ID: 197863 [Multi-domain]  Cd Length: 69  Bit Score: 131.86  E-value: 1.09e-37
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 445981242   374 TIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRK 442
Cdd:smart00760   1 TIEEIIEAVAEYFGVKPEDLKSKSRKREIVLARQIAMYLARELTDLSLPEIGKIFGGRDHSTVLHACRK 69
 
Name Accession Description Interval E-value
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
6-464 0e+00

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 720.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242    6 WQQCLARLQDELPATEFSMWIRPLQA-ELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTSFCGADaPQLRFEVGTKPVT 84
Cdd:TIGR00362   1 WNRILERLEKELSEQEYNTWFKPLKLlSIEGNTLIISVPNEFVKEWIEKNYLDLIEELLQELFGAE-IEIEFTVGEDEEE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242   85 QtlkAAASNTVAPAqaaqvqpqraapstrsgwdNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAY 164
Cdd:TIGR00362  80 L---EPNSKKPEPA-------------------PPEAPAPPSSASGLNPKYTFDNFVVGKSNRLAHAAALAVAENPGKAY 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  165 NPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKER 244
Cdd:TIGR00362 138 NPLFIYGGVGLGKTHLLHAIGNEILENNPNAKVLYVSSEKFTNDFVNALRNNKMEEFKEKYRSVDLLLIDDIQFLAGKER 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  245 SQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFI 324
Cdd:TIGR00362 218 TQEEFFHTFNALHENNKQIVLTSDRPPKELPGLEDRLRSRFEWGLVVDIEPPDLETRLAILQKKAEEEGLELPDEVLEFI 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  325 AKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVAR 404
Cdd:TIGR00362 298 AKNITSNVRELEGALNRLLAYASLTGKPITLELAKEALKDLLRAQKKEITIENIQKVVAKYYNIKVSDLKSKKRTRNIVR 377
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  405 PRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTL 464
Cdd:TIGR00362 378 PRQIAMYLAKELTDLSLPEIGKAFGGRDHTTVLHAVRKIEKLIETDAELKEDIEELKRKL 437
dnaA PRK00149
chromosomal replication initiator protein DnaA;
1-466 0e+00

chromosomal replication initiator protein DnaA;


Pssm-ID: 234667 [Multi-domain]  Cd Length: 401  Bit Score: 711.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242   1 MSLSLWQQCLARLQDELPATEFSMWIRPLQ-AELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTsfcgadapqlrfevg 79
Cdd:PRK00149   1 NLQSLWEKVLERLKDELSEQEYETWIKPLKaLSLEDNTLTLYVPNRFVKDWIEKNYLDLIEEALQ--------------- 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  80 tkpvtqtlkaaasntvapaqaaqvqpqraapstrsgwdnvpapaeptyrsnVNVKHTFDNFVEGKSNQLARAAARQVADN 159
Cdd:PRK00149  66 ---------------------------------------------------LNPKYTFDNFVVGKSNRLAHAAALAVAEN 94
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 160 PGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFF 239
Cdd:PRK00149  95 PGKAYNPLFIYGGVGLGKTHLLHAIGNYILEKNPNAKVVYVTSEKFTNDFVNALRNNTMEEFKEKYRSVDVLLIDDIQFL 174
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 240 ANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGE 319
Cdd:PRK00149 175 AGKERTQEEFFHTFNALHEAGKQIVLTSDRPPKELPGLEERLRSRFEWGLTVDIEPPDLETRIAILKKKAEEEGIDLPDE 254
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 320 VAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRS 399
Cdd:PRK00149 255 VLEFIAKNITSNVRELEGALNRLIAYASLTGKPITLELAKEALKDLLAAQKKKITIENIQKVVAEYYNIKVSDLKSKSRT 334
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 445981242 400 RSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS 466
Cdd:PRK00149 335 RNIARPRQIAMYLAKELTDLSLPEIGRAFGGRDHTTVLHAVRKIEKLLEEDPELKEDVEELKRKLKS 401
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
132-433 0e+00

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 550.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 132 NVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVK 211
Cdd:COG0593    2 NPRYTFDNFVVGPSNRLAHAAALAVAEWPGKAYNPLFLYGGVGLGKTHLLHAIGNEALENNPGARVVYLTAEEFTNDFIN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 212 ALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTV 291
Cdd:COG0593   82 AIRNNTIEEFKEKYRSVDVLLIDDIQFLAGKEATQEEFFHTFNALREAGKQIVLTSDRPPKELPGLEERLRSRLEWGLVV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 292 AIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEK 371
Cdd:COG0593  162 DIQPPDLETRIAILRKKAADRGLELPDEVLEYLARRIERNVRELEGALNRLDAYALLTGRPITLELAREVLKDLLRAQKK 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 445981242 372 LVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDH 433
Cdd:COG0593  242 EITIEDIQKAVAEYFGVSVADLLSKSRTREIARPRQIAMYLARELTDLSLPEIGRAFGGRDH 303
Bac_DnaA pfam00308
Bacterial dnaA protein;
132-349 1.28e-128

Bacterial dnaA protein;


Pssm-ID: 278724 [Multi-domain]  Cd Length: 219  Bit Score: 371.66  E-value: 1.28e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  132 NVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVK 211
Cdd:pfam00308   2 NPRYTFENFVIGPSNRFAHAAALTVAKAPGKAYNPLFIYGGVGLGKTHLLHAIGNYALQNAPNLRVVYLTAEEFLNDFVD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  212 ALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTV 291
Cdd:pfam00308  82 AIRDNKTNQFKEKYRNVDVLLIDDIQFLAGKEGTQEEFFHTFNALHESGKQIVFSSDRPPKELEELEDRLRSRFQWGLVT 161
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 445981242  292 AIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFT 349
Cdd:pfam00308 162 DIEPPDLETRLAILRKKAEAEGIEIPPEVLNFIAQRVTDNVRELEGALNRLLAYSSLN 219
dnaA PRK14086
chromosomal replication initiator protein DnaA;
95-453 1.95e-121

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 367.61  E-value: 1.95e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  95 VAPAQAAQVQPQRAAPSTRSGW-DNVPAPAEPTYRsnVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGT 173
Cdd:PRK14086 246 PERDDAPVVPIRPSAPGPLAAQpAPAPGPGEPTAR--LNPKYTFDTFVIGASNRFAHAAAVAVAEAPAKAYNPLFIYGES 323
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 174 GLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTF 253
Cdd:PRK14086 324 GLGKTHLLHAIGHYARRLYPGTRVRYVSSEEFTNEFINSIRDGKGDSFRRRYREMDILLVDDIQFLEDKESTQEEFFHTF 403
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 254 NALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVR 333
Cdd:PRK14086 404 NTLHNANKQIVLSSDRPPKQLVTLEDRLRNRFEWGLITDVQPPELETRIAILRKKAVQEQLNAPPEVLEFIASRISRNIR 483
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 334 ELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKL-VTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMAL 412
Cdd:PRK14086 484 ELEGALIRVTAFASLNRQPVDLGLTEIVLRDLIPEDSAPeITAAAIMAATADYFGLTVEDLCGTSRSRVLVTARQIAMYL 563
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 445981242 413 AKELTNHSLPEIGDAFgGRDHTTVLHACRKIEQLREESHDI 453
Cdd:PRK14086 564 CRELTDLSLPKIGQQF-GRDHTTVMHADRKIRALMAERRSI 603
PRK12422 PRK12422
chromosomal replication initiator protein DnaA;
6-466 4.09e-77

chromosomal replication initiator protein DnaA;


Pssm-ID: 183521 [Multi-domain]  Cd Length: 445  Bit Score: 247.83  E-value: 4.09e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242   6 WQQCLARLQDELPATEFSMWIRPLQAELSDN-TLALYAPNRFVLDWVRDKYLNNINgllTSFCGADAPQLRFEVGTKPVT 84
Cdd:PRK12422   4 WEEFLLLQEKEIGTETVDKWLRSLKVLCFDAcNLYLEAKDSFQVTWFEEHIRHKVK---ASLVNNNGKPIRVHVTSLDKS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  85 QTLKAAAsntvapaqaaQVQPQRAAPSTRsgwdnvpapaepTYrSNVNVKHTFDNFVEGKSNQLARAAARQVA----DNP 160
Cdd:PRK12422  81 TPFKKEK----------QIQQEKTAYFTM------------KY-GELDPLMTFANFLVTPENDLPHRILQEFTkvseQGK 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 161 GGAYNPLFLYGGTGLGKTHLLHAVGNGImaRKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFA 240
Cdd:PRK12422 138 GFPFNPIYLFGPEGSGKTHLMQAAVHAL--RESGGKILYVRSELFTEHLVSAIRSGEMQRFRQFYRNVDALFIEDIEVFS 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 241 NKERSQEEFFHTFNAL-LEGnQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGE 319
Cdd:PRK12422 216 GKGATQEEFFHTFNSLhTEG-KLIVISSTCAPQDLKAMEERLISRFEWGIAIPLHPLTKEGLRSFLERKAEALSIRIEET 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 320 VAFFIAKRLRSNVRELEGALNRV---IANANFTGRAITIDFVREALRDLLALQEKL-VTIDNIQKTVAEYYKIKVADLLS 395
Cdd:PRK12422 295 ALDFLIEALSSNVKSLLHALTLLakrVAYKKLSHQLLYVDDIKALLHDVLEAAESVrLTPSKIIRAVAQYYGVSPESILG 374
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 445981242 396 KRRSRSVARPRQMAMALAKELTNHSLPEIGDAFgGRDHTTVLHACRKIEQ-LREESHDIKEDFSNLIRTLSS 466
Cdd:PRK12422 375 RSQSREYVLPRQVAMYLCRQKLSLSYVKIGDVF-SRDHSTVISSIRAISQkLEEDDRDISMAIQEITKRLSS 445
Bac_DnaA_C cd06571
C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA ...
375-464 9.25e-44

C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple copies of DnaA, which is an ATPase, bind to 9-mers at the origin and form an initial complex in which the DNA strands are being separated in an ATP-dependent step.


Pssm-ID: 119330 [Multi-domain]  Cd Length: 90  Bit Score: 148.82  E-value: 9.25e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 375 IDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIK 454
Cdd:cd06571    1 IELIIEAVAEYFGISVEDLRSKSRKKEIALARQIAMYLARELTGLSLPEIGRAFGGRDHSTVLHAVRKIEELLEEDPELK 80
                         90
                 ....*....|
gi 445981242 455 EDFSNLIRTL 464
Cdd:cd06571   81 EDVEELEKKL 90
Bac_DnaA_C pfam08299
Bacterial dnaA protein helix-turn-helix;
375-443 1.61e-40

Bacterial dnaA protein helix-turn-helix;


Pssm-ID: 462419 [Multi-domain]  Cd Length: 69  Bit Score: 139.46  E-value: 1.61e-40
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 445981242  375 IDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKI 443
Cdd:pfam08299   1 IEKIIEAVAEYFGISPEDLKSKSRKREIALARQIAMYLARELTDLSLPEIGRAFGGRDHSTVIHACKKI 69
Bac_DnaA_C smart00760
Bacterial dnaA protein helix-turn-helix domain; Could be involved in DNA-binding.
374-442 1.09e-37

Bacterial dnaA protein helix-turn-helix domain; Could be involved in DNA-binding.


Pssm-ID: 197863 [Multi-domain]  Cd Length: 69  Bit Score: 131.86  E-value: 1.09e-37
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 445981242   374 TIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRK 442
Cdd:smart00760   1 TIEEIIEAVAEYFGVKPEDLKSKSRKREIVLARQIAMYLARELTDLSLPEIGKIFGGRDHSTVLHACRK 69
DnaA_homol_Hda TIGR03420
DnaA regulatory inactivator Hda; Members of this protein family are Hda (Homologous to DnaA). ...
136-363 7.40e-33

DnaA regulatory inactivator Hda; Members of this protein family are Hda (Homologous to DnaA). These proteins are about half the length of DnaA and homologous over length of Hda. In the model species Escherichia coli, the initiation of DNA replication requires DnaA bound to ATP rather than ADP; Hda helps facilitate the conversion of DnaA-ATP to DnaA-ADP. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274571 [Multi-domain]  Cd Length: 226  Bit Score: 124.22  E-value: 7.40e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  136 TFDNFVEGkSNQLARAAARQVADNPGGayNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAkvVYMHSERFVQDMVKALqn 215
Cdd:TIGR03420  13 TFDNFYAG-GNAELLAALRQLAAGKGD--RFLYLWGESGSGKSHLLQAACAAAEERGKSA--IYLPLAELAQADPEVL-- 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242  216 NAIEEFkryyrsvDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEP 295
Cdd:TIGR03420  86 EGLEQA-------DLVCLDDVEAIAGQPEWQEALFHLYNRVREAGGRLLIAGRAAPAQLPLRLPDLRTRLAWGLVFQLPP 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 445981242  296 PELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALR 363
Cdd:TIGR03420 159 LSDEEKIAALQSRAARRGLQLPDEVADYLLRHGSRDMGSLMALLDALDRASLAAKRKITIPFVKEVLA 226
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
146-289 2.36e-19

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 84.51  E-value: 2.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 146 NQLARAAARQVADNPggAYNPLFLYGGTGLGKTHLLHAVGNGImaRKPNAKVVYMHSERFVQDMVKALQ----NNAIEEF 221
Cdd:cd00009    3 QEEAIEALREALELP--PPKNLLLYGPPGTGKTTLARAIANEL--FRPGAPFLYLNASDLLEGLVVAELfghfLVRLLFE 78
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 445981242 222 KRYYRSVDALLIDDIQFFANKERSQ-EEFFHTFNALLE--GNQQIILTSDR--YPKEINGVEDRLKSRFGWGL 289
Cdd:cd00009   79 LAEKAKPGVLFIDEIDSLSRGAQNAlLRVLETLNDLRIdrENVRVIGATNRplLGDLDRALYDRLDIRIVIPL 151
PRK08084 PRK08084
DnaA inactivator Hda;
136-363 4.99e-19

DnaA inactivator Hda;


Pssm-ID: 181224 [Multi-domain]  Cd Length: 235  Bit Score: 85.89  E-value: 4.99e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 136 TFDNFVEGKSNQLArAAARQVADNPGGAYnpLFLYGGTGLGKTHLLHAVGNGIMARkpNAKVVYMHSER---FVQDMVKA 212
Cdd:PRK08084  20 TFASFYPGDNDSLL-AALQNALRQEHSGY--IYLWSREGAGRSHLLHAACAELSQR--GRAVGYVPLDKrawFVPEVLEG 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 213 LQnnaieefkryyrSVDALLIDDIQFFANKERSQEEFFHTFNALLE-GNQQIILTSDRYPKEINGVEDRLKSRFGWGLTV 291
Cdd:PRK08084  95 ME------------QLSLVCIDNIECIAGDELWEMAIFDLYNRILEsGRTRLLITGDRPPRQLNLGLPDLASRLDWGQIY 162
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 445981242 292 AIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALR 363
Cdd:PRK08084 163 KLQPLSDEEKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASITAQRKLTIPFVKEILK 234
DnaA_N pfam11638
DnaA N-terminal domain; This family of proteins represents the N-terminal domain of DnaA, a ...
4-65 1.19e-18

DnaA N-terminal domain; This family of proteins represents the N-terminal domain of DnaA, a protein involved in the initiation of bacterial chromosomal replication. The structure of this domain is known. It is also found in three copies in some proteins. The exact function of this domain is uncertain but it has been suggested to play a role in oligomerization.


Pssm-ID: 463316 [Multi-domain]  Cd Length: 65  Bit Score: 79.63  E-value: 1.19e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 445981242    4 SLWQQCLARLQDELPATEFSMWIRPLQAELSDNT--LALYAPNRFVLDWVRDKYLNNINGLLTS 65
Cdd:pfam11638   2 ELWERVLERLRKEVGEQTFNTWIKPLTLVDLDDGgsLTLSVPNRFVRDWVEEHYLDRILELWQE 65
PRK08903 PRK08903
DnaA regulatory inactivator Hda; Validated
136-362 1.10e-14

DnaA regulatory inactivator Hda; Validated


Pssm-ID: 236347 [Multi-domain]  Cd Length: 227  Bit Score: 73.09  E-value: 1.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 136 TFDNFVEGKSNQLARAAARQVADNPGGAYnpLFLYGGTGLGKTHLLHAVGNGIMARKPNAkvVYmhserfvqdmvkaLQN 215
Cdd:PRK08903  16 TFDNFVAGENAELVARLRELAAGPVADRF--FYLWGEAGSGRSHLLQALVADASYGGRNA--RY-------------LDA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 216 NAIEEFKRYYRSVDALLIDDIQFFANKErsQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEP 295
Cdd:PRK08903  79 ASPLLAFDFDPEAELYAVDDVERLDDAQ--QIALFNLFNRVRAHGQGALLVAGPAAPLALPLREDLRTRLGWGLVYELKP 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 445981242 296 PELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREAL 362
Cdd:PRK08903 157 LSDADKIAALKAAAAERGLQLADEVPDYLLTHFRRDMPSLMALLDALDRYSLEQKRPVTLPLLREML 223
PRK06030 PRK06030
hypothetical protein; Provisional
382-449 1.57e-11

hypothetical protein; Provisional


Pssm-ID: 180356  Cd Length: 124  Bit Score: 61.33  E-value: 1.57e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 445981242 382 VAEYYKIKVADLLS-KRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGgRDHTTVLHACRKIEQLREE 449
Cdd:PRK06030  32 LALAFGVSGAEIASpLRGRREVSRIRQIAMYVAHVSLGWPMNEVALAFG-RDRTTVGHACHTVEDLRDD 99
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
136-267 2.67e-11

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 63.65  E-value: 2.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 136 TFDNFVEGKSNQLARAAARQVADnpgGAY----NPLFLYGGTGLGKTHLLHAVGN-GIMARKpnaKVVYMHSERFVQDMV 210
Cdd:COG1484   70 TLEDFDFDAQPGLDRRQILELAT---LDFiergENLILLGPPGTGKTHLAIALGHeACRAGY---RVRFTTAPDLVNELK 143
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 445981242 211 KALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEgNQQIILTS 267
Cdd:COG1484  144 EARADGRLERLLKRLAKVDLLILDELGYLPLDAEGAELLFELISDRYE-RRSTIITS 199
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
165-285 8.08e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 51.61  E-value: 8.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242   165 NPLFLYGGTGLGKTHLLHAVGNgiMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRY---------------YRSVD 229
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALAR--ELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASgsgelrlrlalalarKLKPD 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 445981242   230 ALLIDDIQFFANKERSQEEFFHTFNALL-----EGNQQIILTSDRYPKEIngvEDRLKSRF 285
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLlllksEKNLTVILTTNDEKDLG---PALLRRRF 138
PRK06835 PRK06835
DNA replication protein DnaC; Validated
129-285 9.50e-08

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 53.75  E-value: 9.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 129 SNVNVKHTFDNF--------VEGKSNQLARAAARQVA----------DNPGGAynpLFLYGGTGLGKTHLLHAVGNGIMA 190
Cdd:PRK06835 133 KEILKEENFSNFnlnyysdeKDDDEPLSPRKNMEKILekcknfienfDKNNEN---LLFYGNTGTGKTFLSNCIAKELLD 209
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 191 RKpnAKVVYMHSERFVQDMVKA-LQNNAIEEFKR-YYRSVDALLIDDIQFFANKERSQEEFFHTFNA-LLEGNQQIILT- 266
Cdd:PRK06835 210 RG--KSVIYRTADELIEILREIrFNNDKELEEVYdLLINCDLLIIDDLGTEKITEFSKSELFNLINKrLLRQKKMIISTn 287
                        170       180
                 ....*....|....*....|....*
gi 445981242 267 ------SDRYPKEINGvedRLKSRF 285
Cdd:PRK06835 288 lsleelLKTYSERISS---RLLGNF 309
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
167-236 1.27e-06

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 49.87  E-value: 1.27e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 167 LFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSerFVQDMVKALQNNAIEEFKRYYRSVDALLIDDI 236
Cdd:PRK08939 159 LYLYGDFGVGKSYLLAAIANELAKKGVSSTLLHFPE--FIRELKNSISDGSVKEKIDAVKEAPVLMLDDI 226
PRK06921 PRK06921
hypothetical protein; Provisional
134-293 4.61e-06

hypothetical protein; Provisional


Pssm-ID: 180750 [Multi-domain]  Cd Length: 266  Bit Score: 48.24  E-value: 4.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 134 KHTFDNFV-EGKSNQLARA---AARQVADNP---GGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFV 206
Cdd:PRK06921  80 KLTFKNFKtEGKPQAIKDAyecAVEYVKDFEkiqESRKNSIALLGQPGSGKTHLLTAAANELMRKKGVPVLYFPFVEGFG 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 207 QdmvkaLQNN--AIEEFKRYYRSVDALLIDDIQFFANKERSQEEF-----FHTFNALLEGNQQIILTSDRYPKEINGVED 279
Cdd:PRK06921 160 D-----LKDDfdLLEAKLNRMKKVEVLFIDDLFKPVNGKPRATEWqieqmYSVLNYRYLNHKPILISSELTIDELLDIDE 234
                        170
                 ....*....|....*..
gi 445981242 280 RLKSRF---GWGLTVAI 293
Cdd:PRK06921 235 ALGSRIvemCKDYLVII 251
PRK08116 PRK08116
hypothetical protein; Validated
136-284 1.13e-05

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 46.94  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 136 TFDNF-VEGKSNQLARAAARQV-------ADNPGgaynpLFLYGGTGLGKTHLLHAVGNGIMARKpnAKVVYMHSERFVQ 207
Cdd:PRK08116  83 TFENFlFDKGSEKAYKIARKYVkkfeemkKENVG-----LLLWGSVGTGKTYLAACIANELIEKG--VPVIFVNFPQLLN 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 208 DMVKALQNNAIEEFKRYYRSV---DALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEI-NGVEDRLKS 283
Cdd:PRK08116 156 RIKSTYKSSGKEDENEIIRSLvnaDLLILDDLGAERDTEWAREKVYNIIDSRYRKGLPTIVTTNLSLEELkNQYGKRIYD 235

                 .
gi 445981242 284 R 284
Cdd:PRK08116 236 R 236
PRK06620 PRK06620
hypothetical protein; Validated
126-362 1.25e-05

hypothetical protein; Validated


Pssm-ID: 168630  Cd Length: 214  Bit Score: 46.37  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 126 TYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGgaYNP----LFLYGGTGLGKTHLlhavgNGIMARKPNAkvvYMH 201
Cdd:PRK06620   4 IFRFTTSSKYHPDEFIVSSSNDQAYNIIKNWQCGFG--VNPykftLLIKGPSSSGKTYL-----TKIWQNLSNA---YII 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 202 SERFVqdmvkalqnnaIEEFkryYRSVDALLIDDIQFFANKErsqeeFFHTFNALLEGNQQIILTSDRYPKeiNGVEDRL 281
Cdd:PRK06620  74 KDIFF-----------NEEI---LEKYNAFIIEDIENWQEPA-----LLHIFNIINEKQKYLLLTSSDKSR--NFTLPDL 132
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 282 KSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREA 361
Cdd:PRK06620 133 SSRIKSVLSILLNSPDDELIKILIFKHFSISSVTISRQIIDFLLVNLPREYSKIIEILENINYFALISKRKITISLVKEV 212

                 .
gi 445981242 362 L 362
Cdd:PRK06620 213 L 213
PRK12377 PRK12377
putative replication protein; Provisional
134-236 4.37e-05

putative replication protein; Provisional


Pssm-ID: 183482 [Multi-domain]  Cd Length: 248  Bit Score: 44.83  E-value: 4.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 134 KHTFDNF-VEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYmhserfVQDMVKA 212
Cdd:PRK12377  70 KCSFANYqVQNDGQRYALSQAKSIADELMTGCTNFVFSGKPGTGKNHLAAAIGNRLLAKGRSVIVVT------VPDVMSR 143
                         90       100
                 ....*....|....*....|....*....
gi 445981242 213 LQN-----NAIEEFKRYYRSVDALLIDDI 236
Cdd:PRK12377 144 LHEsydngQSGEKFLQELCKVDLLVLDEI 172
PRK07952 PRK07952
DNA replication protein DnaC; Validated
136-236 7.98e-04

DNA replication protein DnaC; Validated


Pssm-ID: 181180 [Multi-domain]  Cd Length: 244  Bit Score: 40.91  E-value: 7.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242 136 TFDNF-VEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYmhserfVQDMVKALQ 214
Cdd:PRK07952  70 SFENYrVECEGQMNALSKARQYVEEFDGNIASFIFSGKPGTGKNHLAAAICNELLLRGKSVLIIT------VADIMSAMK 143
                         90       100
                 ....*....|....*....|....*...
gi 445981242 215 ------NNAIEEFKRYYRSVDALLIDDI 236
Cdd:PRK07952 144 dtfsnsETSEEQLLNDLSNVDLLVIDEI 171
PRK06672 PRK06672
hypothetical protein; Validated
2-78 1.59e-03

hypothetical protein; Validated


Pssm-ID: 180654 [Multi-domain]  Cd Length: 341  Bit Score: 40.52  E-value: 1.59e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 445981242   2 SLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTSFCGaDAPQLRFEV 78
Cdd:PRK06672 191 SKTIWNKIKDKMQLKISRPSYETWVKETTARINEDSLIIYFENEFQQEWVKKSYKDLISQIAKELTG-NTYEIQFEL 266
PRK06672 PRK06672
hypothetical protein; Validated
3-85 8.37e-03

hypothetical protein; Validated


Pssm-ID: 180654 [Multi-domain]  Cd Length: 341  Bit Score: 38.20  E-value: 8.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981242   3 LSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTSFCGADApQLRFEVGTKP 82
Cdd:PRK06672  92 LSSWDEVKKALRPKIAEKTFMTWIRNTNATIKDNKVIIFCEDAFHRDLLEGEYKNIISSTVQKITDEEY-QIWFEIGSSA 170

                 ...
gi 445981242  83 VTQ 85
Cdd:PRK06672 171 TSK 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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