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Conserved domains on  [gi|445981824|ref|WP_000059679|]
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MULTISPECIES: DeoR/GlpR family DNA-binding transcription regulator [Enterobacteriaceae]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 9-256 2.04e-95

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


:

Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 280.48  E-value: 2.04e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824   9 NPRHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAGRASSV-VNTAFEQREVSQTEEKKAIA 87
Cdd:COG1349    4 EERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAaAEPPFAERETLNAEEKRAIA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  88 EAVADYIPDGSTIFITIGTTVEHVARALLNHNHLRIITNSLRVAHILYHNPRFEVMVPGGTLRSHNSGIIGPSAASFVAD 167
Cdd:COG1349   84 RAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEALRR 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824 168 FRADYLVTSVGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDELPPAALKSRL 247
Cdd:COG1349  164 FRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLEAL 243


                 ....*....
gi 445981824 248 QDSQIEIIL 256
Cdd:COG1349  244 EEAGVEVIV 252
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 9-256 2.04e-95

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 280.48  E-value: 2.04e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824   9 NPRHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAGRASSV-VNTAFEQREVSQTEEKKAIA 87
Cdd:COG1349    4 EERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAaAEPPFAERETLNAEEKRAIA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  88 EAVADYIPDGSTIFITIGTTVEHVARALLNHNHLRIITNSLRVAHILYHNPRFEVMVPGGTLRSHNSGIIGPSAASFVAD 167
Cdd:COG1349   84 RAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEALRR 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824 168 FRADYLVTSVGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDELPPAALKSRL 247
Cdd:COG1349  164 FRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLEAL 243


                 ....*....
gi 445981824 248 QDSQIEIIL 256
Cdd:COG1349  244 EEAGVEVIV 252
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
11-256 1.99e-77

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 234.75  E-value: 1.99e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  11 RHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAGRASSVVNTAFEQREVSQTEEKKAIAEAV 90
Cdd:PRK10906   6 RHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAALPSSSVNTPWHDRKATQTEEKERIARKV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  91 ADYIPDGSTIFITIGTTVEHVARALLNHNHLRIITNSLRVAHILYHNPRFEVMVPGGTLRSHNSGIIGPSAASFVADFRA 170
Cdd:PRK10906  86 ASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATLDFISQFRL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824 171 DYLVTSVGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDELPPAALKSRLQDS 250
Cdd:PRK10906 166 DFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQLPPASVMQVIEDH 245


                 ....*.
gi 445981824 251 QIEIIL 256
Cdd:PRK10906 246 HVQLEL 251
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 78-237 5.68e-61

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 189.64  E-value: 5.68e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824   78 SQTEEKKAIAEAVADYIPDGSTIFITIGTTVEHVARALLNHNHLRIITNSLRVAHILYHNPRFEVMVPGGTLRSHNSGII 157
Cdd:pfam00455   1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  158 GPSAASFVADFRADYLVTSVGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDE 237
Cdd:pfam00455  81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
TranRegGlpR_Halo NF041397
HTH-type transcriptional regulator GlpR;
18-255 9.94e-50

HTH-type transcriptional regulator GlpR;


Pssm-ID: 469288 [Multi-domain]  Cd Length: 253  Bit Score: 163.93  E-value: 9.94e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  18 LIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAGRASSV-VNTAFEQREVSQTEEKKAIAEAVADYIPD 96
Cdd:NF041397  13 LVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGGAVPVTSVgRERSYGQREVQNLEAKRAIAERAVEEIHD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  97 GSTIFITIGTTVEHVARALLNHNHLRIITNSLRVAHILYHNpRFEVMVPGGTLRSHNSGIIGPSAASFVADFRADYLVTS 176
Cdd:NF041397  93 GQVVFFDAGTTTMEVAKRVPTDGSFLAVTNSPLLALELAER-DGEVKLTGGTLRPRTRALVGPTAESFMERTNFDLLFLG 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 445981824 177 VGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDELPPAALKSRLQDSQIEII 255
Cdd:NF041397 172 TNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVDLFVTDGALPEELREAFEEAGVEVV 250
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
11-61 7.92e-19

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 77.65  E-value: 7.92e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 445981824    11 RHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGA 61
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGA 51
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 14-60 1.73e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 41.90  E-value: 1.73e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 445981824  14 QLLMLIAERGyMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGG 60
Cdd:cd00090   11 RILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG 56
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 9-256 2.04e-95

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 280.48  E-value: 2.04e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824   9 NPRHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAGRASSV-VNTAFEQREVSQTEEKKAIA 87
Cdd:COG1349    4 EERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAaAEPPFAERETLNAEEKRAIA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  88 EAVADYIPDGSTIFITIGTTVEHVARALLNHNHLRIITNSLRVAHILYHNPRFEVMVPGGTLRSHNSGIIGPSAASFVAD 167
Cdd:COG1349   84 RAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEALRR 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824 168 FRADYLVTSVGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDELPPAALKSRL 247
Cdd:COG1349  164 FRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLEAL 243


                 ....*....
gi 445981824 248 QDSQIEIIL 256
Cdd:COG1349  244 EEAGVEVIV 252
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
11-256 1.99e-77

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 234.75  E-value: 1.99e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  11 RHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAGRASSVVNTAFEQREVSQTEEKKAIAEAV 90
Cdd:PRK10906   6 RHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAALPSSSVNTPWHDRKATQTEEKERIARKV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  91 ADYIPDGSTIFITIGTTVEHVARALLNHNHLRIITNSLRVAHILYHNPRFEVMVPGGTLRSHNSGIIGPSAASFVADFRA 170
Cdd:PRK10906  86 ASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATLDFISQFRL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824 171 DYLVTSVGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDELPPAALKSRLQDS 250
Cdd:PRK10906 166 DFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQLPPASVMQVIEDH 245


                 ....*.
gi 445981824 251 QIEIIL 256
Cdd:PRK10906 246 HVQLEL 251
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 78-237 5.68e-61

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 189.64  E-value: 5.68e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824   78 SQTEEKKAIAEAVADYIPDGSTIFITIGTTVEHVARALLNHNHLRIITNSLRVAHILYHNPRFEVMVPGGTLRSHNSGII 157
Cdd:pfam00455   1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  158 GPSAASFVADFRADYLVTSVGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDE 237
Cdd:pfam00455  81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
TranRegGlpR_Halo NF041397
HTH-type transcriptional regulator GlpR;
18-255 9.94e-50

HTH-type transcriptional regulator GlpR;


Pssm-ID: 469288 [Multi-domain]  Cd Length: 253  Bit Score: 163.93  E-value: 9.94e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  18 LIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAGRASSV-VNTAFEQREVSQTEEKKAIAEAVADYIPD 96
Cdd:NF041397  13 LVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGGAVPVTSVgRERSYGQREVQNLEAKRAIAERAVEEIHD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  97 GSTIFITIGTTVEHVARALLNHNHLRIITNSLRVAHILYHNpRFEVMVPGGTLRSHNSGIIGPSAASFVADFRADYLVTS 176
Cdd:NF041397  93 GQVVFFDAGTTTMEVAKRVPTDGSFLAVTNSPLLALELAER-DGEVKLTGGTLRPRTRALVGPTAESFMERTNFDLLFLG 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 445981824 177 VGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDELPPAALKSRLQDSQIEII 255
Cdd:NF041397 172 TNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVDLFVTDGALPEELREAFEEAGVEVV 250
PRK09802 PRK09802
DeoR family transcriptional regulator;
11-256 1.17e-29

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 112.26  E-value: 1.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  11 RHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGA---GRASSVVNTAFEQREVSQTEEKKAIA 87
Cdd:PRK09802  18 RREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGAlicDSTTPSVEPSVEDKSALNTAMKRSVA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  88 EAVADYIPDGSTIFITIGTTVEHVARALLNHNHLRIITNSLRVAHILYHNPRFEVMVPGGTLRSHNSGIIGPSAASFVAD 167
Cdd:PRK09802  98 KAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQAEQSLQN 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824 168 FRADYLVTSVGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDELPPAALKSRL 247
Cdd:PRK09802 178 YHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPADSLEGL 257


                 ....*....
gi 445981824 248 QDSQIEIIL 256
Cdd:PRK09802 258 RKAGVEVIL 266
srlR PRK10434
DNA-binding transcriptional repressor;
11-260 8.77e-28

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 107.08  E-value: 8.77e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  11 RHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAgrassVVNTAFEQREVSQ-----TEEKKA 85
Cdd:PRK10434   6 RQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGV-----VLNKEESDPPIDHktlinTHKKEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  86 IAEAVADYIPDGSTIFITIGTTVEHVARALLNHNHLRIITNSLR-VAHILYHNPRFEVMVPGGTLRSHNSGIIGPSAASF 164
Cdd:PRK10434  81 IAEAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHiVNALSELDNEQTILMPGGTFRKKSASFHGQLAENA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824 165 VADFRADYLVTSVGAIESDGALMEFdvNEANVVKTMMAH-ARNILLVADHTKYHASAAVEIGNVAQVTALFTDELPPAAL 243
Cdd:PRK10434 161 FEHFTFDKLFIGTDGIDLNAGVTTF--NEVYTVSKAMCNaAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAF 238

                        250
                 ....*....|....*..
gi 445981824 244 KSRLQDSQIEIILPQED 260
Cdd:PRK10434 239 RQALEEKGIEVIITGES 255
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
6-256 5.86e-25

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 99.31  E-value: 5.86e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824   6 LTGNPRHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAgRASSVVNTAFEQREVSQTE---E 82
Cdd:PRK13509   1 MTEAQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGA-EAITQQRPRWTPMNIHQAQnhdE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  83 KKAIAEAVADYIPDGSTIFITIGTTVEHVARALLNHNhLRIITNSLRVAHILYHNPRFEVMVPGGTLRSHNSGIIGPsAA 162
Cdd:PRK13509  80 KVRIAKAASQLCNPGESVVINCGSTAFLLGRELCGKP-VQIITNYLPLANYLIDQEHDSVIIMGGQYNKSQSITLSP-QG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824 163 SFVADFRADYLVTSVGAIESDGaLMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFT-DELPPA 241
Cdd:PRK13509 158 SENSLYAGHWMFTSGKGLTADG-LYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITgKNADPE 236

                        250
                 ....*....|....*
gi 445981824 242 ALKSrLQDSQIEIIL 256
Cdd:PRK13509 237 VLQQ-LEAQGVSILL 250
PRK10411 PRK10411
L-fucose operon activator;
9-241 3.59e-24

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 97.18  E-value: 3.59e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824   9 NPRHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAG---RASSVVNTAFEQREVSQTEEKKA 85
Cdd:PRK10411   3 AARQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKyihRQNQDSGDPFHIRLKSHYAHKAD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  86 IAEAVADYIPDGSTIFITIGTTVEHVARALLNHNhLRIITNSLRVAHILYHNPRFEVMVPGGTLRSHNSGIIGPSAASFV 165
Cdd:PRK10411  83 IAREALAWIEEGMVIALDASSTCWYLARQLPDIN-IQVFTNSHPICQELGKRERIQLISSGGTLERKYGCYVNPSLISQL 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 445981824 166 ADFRADYLVTSVGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDELPPA 241
Cdd:PRK10411 162 KSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQVA 237
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
11-67 1.21e-20

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 82.31  E-value: 1.21e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 445981824   11 RHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAGRASSV 67
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVSNSST 57
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
11-61 7.92e-19

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 77.65  E-value: 7.92e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 445981824    11 RHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGA 61
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGA 51
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 11-255 2.73e-11

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 62.02  E-value: 2.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  11 RHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITrhhGG--AGRASSVVNTAFEQREVSQTEEKKAIAE 88
Cdd:PRK10681   8 RIGQLLQALKRSDKLHLKDAAALLGVSEMTIRRDLNAHSAPVVLL---GGyiVLEPRSASHYLLSDQKSRLVEEKRRAAQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  89 AVADYIPDGSTIFITIGTTVEHVARALLNHNHLRIITNSLRVAHILYHNPRFEVMVPGGTLRSHNSgIIGP-SAASFVAD 167
Cdd:PRK10681  85 LAATLVEPNQTLFFDCGTTTPWIIEAIDNELPFTAVCYSLNTFLALQEKPHCRAILCGGEFHASNA-IFKPlDFQQTLDN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824 168 FRADYLVTSVGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDELPPAALKSRL 247
Cdd:PRK10681 164 ICPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMAMAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSDRCPDDEFVKYA 243


                 ....*...
gi 445981824 248 QDSQIEII 255
Cdd:PRK10681 244 QAQRIKLM 251
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
10-63 7.67e-08

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 51.46  E-value: 7.67e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 445981824  10 PRHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRH--HGGAGR 63
Cdd:COG2345   13 PTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVEREteRRGRGR 68
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 15-54 1.05e-07

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 47.43  E-value: 1.05e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 445981824   15 LLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLI 54
Cdd:pfam08279   4 LQLLLEARGPISGQELAEKLGVSRRTIRRDIKILEELGVP 43
DeoR COG2390
DNA-binding transcriptional regulator LsrR, DeoR family [Transcription];
25-124 1.47e-07

DNA-binding transcriptional regulator LsrR, DeoR family [Transcription];


Pssm-ID: 441955 [Multi-domain]  Cd Length: 301  Bit Score: 51.28  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  25 MNIDELANLLDVSTQTVRRDIRKLSEQGL----ITRHHGGAGRASSVVNTAFEQREV------SQTEE--KKAIAEAVAD 92
Cdd:COG2390   11 LTQREIAERLGISRRTVSRLLAEAREEGLvrisITDPLAGLLELERELRERFGLKEVivvpgdSDDDEevLRALGRAAAE 90

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 445981824  93 Y----IPDGSTIFITIGTTVEHVARAL--LNHNHLRII 124
Cdd:COG2390   91 YlerlLKDGDVIGVGWGRTLAAVAEALppLPLPDVTVV 128
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 11-62 7.76e-07

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 49.31  E-value: 7.76e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 445981824  11 RHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGL-ITRHHGGAG 62
Cdd:COG2378    6 RLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRELGVpIEAERGRGG 58
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
11-60 3.42e-06

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 47.20  E-value: 3.42e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 445981824  11 RHDqLLMLIAERGyMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGG 60
Cdd:COG4742   18 RKN-ILLLLAEGP-KTRSELAESLDVSRSTILRQLKELEERGLIERDDGE 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 14-60 1.73e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 41.90  E-value: 1.73e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 445981824  14 QLLMLIAERGyMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGG 60
Cdd:cd00090   11 RILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG 56
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 15-56 3.77e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 40.61  E-value: 3.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 445981824   15 LLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITR 56
Cdd:pfam01047   8 ILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIER 49
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
15-56 1.07e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 40.27  E-value: 1.07e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 445981824    15 LLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITR 56
Cdd:smart00347  15 VLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRR 56
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
29-115 1.78e-04

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 41.77  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445981824  29 ELANLLDVSTQTVRRDIRKLSEQGLITRHHgGAGrasSVVNtafEQREVSQTEEKKAIAEAVADYIPDGSTIFITIGTTV 108
Cdd:COG2188   34 ELAEEFGVSRMTVRKALDELVEEGLLERRQ-GRG---TFVA---EPKIEYPLSRLTSFTEELRARGREPSTRVLSAERVP 106


                 ....*....
gi 445981824 109 --EHVARAL 115
Cdd:COG2188  107 adEEVAEAL 115
COG4190 COG4190
Predicted transcriptional regulator, contains HTH domain [Transcription];
9-73 1.84e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443344  Cd Length: 121  Bit Score: 40.26  E-value: 1.84e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 445981824   9 NPRHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAGRASSVVNTAFE 73
Cdd:COG4190   51 TPKRLELLRAIAEEGPESIRELARRLGRDVKNVHRDLKTLEELGLVELEEDGRAKRPVVPYDEIE 115
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 13-59 1.97e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 38.58  E-value: 1.97e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 445981824  13 DQLLMLIAERGY------MNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHG 59
Cdd:cd07377    8 DQLREAILSGELkpgdrlPSERELAEELGVSRTTVREALRELEAEGLVERRPG 60
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
15-56 2.03e-04

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 40.33  E-value: 2.03e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 445981824  15 LLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITR 56
Cdd:COG3355   33 YLILLENGEPLTVEELAEALDRSRSTVYRSLQKLLEAGLVER 74
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
15-60 2.56e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 40.19  E-value: 2.56e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 445981824  15 LLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGG 60
Cdd:COG1321   15 IYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYG 60
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 9-56 3.85e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 37.57  E-value: 3.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 445981824    9 NPRHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITR 56
Cdd:pfam12802   4 TPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVER 51
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 11-63 4.24e-04

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 37.65  E-value: 4.24e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 445981824  11 RHDQLLMLIAER--------GYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAGR 63
Cdd:cd00092    4 RLASFLLNLSLRygagdlvqLPLTRQEIADYLGLTRETVSRTLKELEEEGLISRRGRGKYR 64
Rfk COG1339
Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal ...
 14-56 4.88e-04

Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal CTP-dependent riboflavin kinase is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis


Pssm-ID: 440950 [Multi-domain]  Cd Length: 219  Bit Score: 40.21  E-value: 4.88e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 445981824  14 QLLMLIAERGYMNI--DELANLLDVSTQTVRRDIRKLSEQGLITR 56
Cdd:COG1339   10 LLALLGALKGPVKIssSELAKRLGISQQTASRRLQELEDAGLIER 54
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 17-61 4.95e-04

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 37.59  E-value: 4.95e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 445981824   17 MLIAERgymnidELANLLDVSTQTVRRDIRKLSEQGLITRHHGGA 61
Cdd:pfam00392  23 KLPSER------ELAAEFGVSRTTVREALRRLEAEGLVERRQGRG 61
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 10-77 9.41e-04

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 39.13  E-value: 9.41e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 445981824  10 PRHDQLLMLI----AERGYM-NIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAgRASSVVNTAFEQREV 77
Cdd:COG1974    6 KRQREILDFIkeyiRERGYPpSQREIAEALGLSSSAVHRHLKALEKKGYLRRDPGKS-RAIELLPASPEVVGL 77
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
14-60 1.05e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 36.80  E-value: 1.05e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 445981824    14 QLLMLIAERGyMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGG 60
Cdd:smart00418   1 KILKLLAEGE-LCVCELAEILGLSQSTVSHHLKKLREAGLVESRREG 46
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
9-58 1.33e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 38.03  E-value: 1.33e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 445981824   9 NPRHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHH 58
Cdd:COG1846   37 TPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREP 86
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 15-58 1.75e-03

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 35.90  E-value: 1.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 445981824   15 LLMLIAERGYMNID------ELANLLDVSTQTVRRDIRKLSEQGLITRHH 58
Cdd:pfam13545   7 LLELAARDGGGRIDlpltqeDLADLLGTTRETVSRVLSELRREGLIERGR 56
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
14-54 1.97e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 35.10  E-value: 1.97e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 445981824   14 QLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLI 54
Cdd:pfam13412   5 KILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
BglG COG3711
Transcriptional antiterminator [Transcription];
15-48 2.03e-03

Transcriptional antiterminator [Transcription];


Pssm-ID: 442925 [Multi-domain]  Cd Length: 618  Bit Score: 39.07  E-value: 2.03e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 445981824  15 LLMLIAERGYMNIDELANLLDVSTQTVRRDIRKL 48
Cdd:COG3711    2 LKILLKNNNVVTAKELAKKLNVSERTIRYDIKKI 35
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
15-60 3.40e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 37.17  E-value: 3.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 445981824  15 LLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGG 60
Cdd:COG3398  102 ILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDG 147
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 14-58 3.42e-03

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 36.34  E-value: 3.42e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 445981824    14 QLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHH 58
Cdd:smart00344   7 KILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYT 51
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
18-61 4.81e-03

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 34.47  E-value: 4.81e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 445981824    18 LIAERgymnidELANLLDVSTQTVRRDIRKLSEQGLITRHHGGA 61
Cdd:smart00345  20 LPSER------ELAAQLGVSRTTVREALSRLEAEGLVQRRPGSG 57
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
14-58 5.03e-03

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 36.29  E-value: 5.03e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 445981824  14 QLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHH 58
Cdd:COG1522    9 RILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYG 53
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 29-60 5.46e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 34.44  E-value: 5.46e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 445981824   29 ELANLLDVSTQTVRRDIRKLSEQGLITRHHGG 60
Cdd:pfam12840  29 ELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
HTH_Mga pfam08280
M protein trans-acting positive regulator (MGA) HTH domain; Mga is a DNA-binding protein that ...
 14-50 6.28e-03

M protein trans-acting positive regulator (MGA) HTH domain; Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions.


Pssm-ID: 311953 [Multi-domain]  Cd Length: 59  Bit Score: 34.12  E-value: 6.28e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 445981824   14 QLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSE 50
Cdd:pfam08280   9 KLLELLTENKSITLDELAEELGLSELTLQSDIHELNE 45
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
25-59 8.86e-03

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 33.57  E-value: 8.86e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 445981824    25 MNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHG 59
Cdd:smart00419   9 LTRQEIAELLGLTRETVSRTLKRLEKEGLISREGG 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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