NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|445988091|ref|WP_000065946|]
View 

MULTISPECIES: amino acid permease [Enterobacteriaceae]

Protein Classification

amino acid permease( domain architecture ID 11435282)

amino acid permease similar to Schizosaccharomyces pombe vacuolar amino acid transporter 5 that is involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine, and required for sporulation

Gene Ontology:  GO:0006865

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SdaC COG0814
Amino acid permease [Amino acid transport and metabolism];
1-409 1.05e-93

Amino acid permease [Amino acid transport and metabolism];


:

Pssm-ID: 440576  Cd Length: 401  Bit Score: 287.04  E-value: 1.05e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091   1 MSNIWSKEETLWSFALYGTAVGAGTLFLPIQLGSAGAVVLFITALVAWPLTYWPHKALCQFILSSKtsAGEGITGAVTHY 80
Cdd:COG0814    4 KAMKWRKSDLGWVLLIAGTAIGAGMLALPIAAGGGGFWPSLLLLLLAWPLMYLSHLLLLEVNLSSP--PGADITTVVEEY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091  81 YGKKIGNLITTLYFIAFFVVVLIYAVAITNSLTEQLAKHMVIDLrIRMLVSLGVVLILNLIFLMGRHATIRVMGFLVFPL 160
Cdd:COG0814   82 LGKGGGILIGLLYFFLLYPLLLAYISGGGNILASFLVNQLGLTI-PRWLLSLIFILVLGAIVWLGTRLVDRVNRILVFPK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 161 IAYFLFLSIYLVGSWQPDLLTTQVEFnqNTLHQIWISIPVMVFAFSHTPIISTFAIDrrekYGEHAmDKCKKIMKVAYLI 240
Cdd:COG0814  161 IIAFLLLSLYLIPHWNLANLLNSALP--SYLKYLWLALPVLLTSFGFHPIIPSLVKY----YRKDA-KKLRRAILIGSLI 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 241 ICISVLFFVFSCLLSIPPSYIEAAKEEGVTILSALSMLPNAPaWLSISGIIVAVVAMSKSFLGTYFGVIEGATEVVKttl 320
Cdd:COG0814  234 PLVIYLFWVFSCLGSLPPEEFAEAKAQNISLLSALANVFNSP-LISYLGPLFAFFAIATSFLGVYLGLFDFLADLFK--- 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 321 qqvgiKKSRAFNRALSIMLVSLITFIVCCINPNAISMIYAISGPLIAMILFIMPTLSTYLIPALKPWR------SIGNLI 394
Cdd:COG0814  310 -----KKKSKKGRLKTALLTFLPPWIVALLNPSIFILALGYAGPIIAILLFILPALLVWKVRARFPLKyrvpggKLSLIF 384

                        410
                 ....*....|....*
gi 445988091 395 TLIVGILCVSVMFFS 409
Cdd:COG0814  385 VILFGLLAISAQILS 399
 
Name Accession Description Interval E-value
SdaC COG0814
Amino acid permease [Amino acid transport and metabolism];
1-409 1.05e-93

Amino acid permease [Amino acid transport and metabolism];


Pssm-ID: 440576  Cd Length: 401  Bit Score: 287.04  E-value: 1.05e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091   1 MSNIWSKEETLWSFALYGTAVGAGTLFLPIQLGSAGAVVLFITALVAWPLTYWPHKALCQFILSSKtsAGEGITGAVTHY 80
Cdd:COG0814    4 KAMKWRKSDLGWVLLIAGTAIGAGMLALPIAAGGGGFWPSLLLLLLAWPLMYLSHLLLLEVNLSSP--PGADITTVVEEY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091  81 YGKKIGNLITTLYFIAFFVVVLIYAVAITNSLTEQLAKHMVIDLrIRMLVSLGVVLILNLIFLMGRHATIRVMGFLVFPL 160
Cdd:COG0814   82 LGKGGGILIGLLYFFLLYPLLLAYISGGGNILASFLVNQLGLTI-PRWLLSLIFILVLGAIVWLGTRLVDRVNRILVFPK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 161 IAYFLFLSIYLVGSWQPDLLTTQVEFnqNTLHQIWISIPVMVFAFSHTPIISTFAIDrrekYGEHAmDKCKKIMKVAYLI 240
Cdd:COG0814  161 IIAFLLLSLYLIPHWNLANLLNSALP--SYLKYLWLALPVLLTSFGFHPIIPSLVKY----YRKDA-KKLRRAILIGSLI 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 241 ICISVLFFVFSCLLSIPPSYIEAAKEEGVTILSALSMLPNAPaWLSISGIIVAVVAMSKSFLGTYFGVIEGATEVVKttl 320
Cdd:COG0814  234 PLVIYLFWVFSCLGSLPPEEFAEAKAQNISLLSALANVFNSP-LISYLGPLFAFFAIATSFLGVYLGLFDFLADLFK--- 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 321 qqvgiKKSRAFNRALSIMLVSLITFIVCCINPNAISMIYAISGPLIAMILFIMPTLSTYLIPALKPWR------SIGNLI 394
Cdd:COG0814  310 -----KKKSKKGRLKTALLTFLPPWIVALLNPSIFILALGYAGPIIAILLFILPALLVWKVRARFPLKyrvpggKLSLIF 384

                        410
                 ....*....|....*
gi 445988091 395 TLIVGILCVSVMFFS 409
Cdd:COG0814  385 VILFGLLAISAQILS 399
PRK13629 PRK13629
threonine/serine transporter TdcC; Provisional
 5-403 5.09e-59

threonine/serine transporter TdcC; Provisional


Pssm-ID: 184191  Cd Length: 443  Bit Score: 198.53  E-value: 5.09e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091   5 WSKEETLWSFALYGTAVGAGTLFLPIQLGSAGAVVLFITALVAWPLTYWPHKALCQFILSSKTSAGEgITGAVTHYYGKK 84
Cdd:PRK13629  17 WRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGN-ITETVEEHFGKT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091  85 IGNLITTLYFIAFFVVVLIYAVAITNSLTEQLAKHMVIDLRIRMLVSLGVVLILNLIFLMGRHATIRVMGFLVFPLIAYF 164
Cdd:PRK13629  96 GGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 165 LFLSIYLVGSWQPDLLtTQVEFNQ-------NTLHQIWISIPVMVFAFSHTPIISTFAIDRREKY-----GEHAMDKCKK 232
Cdd:PRK13629 176 VLISLSLIPYWNSAVI-DQVDLGSlsltghdGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYekdfgRDFTERKCSQ 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 233 IMKVAYLIICISVLFFVFSCLLSIPPSYIEAAKEEGVTILSAL-----SMLPNAPAW---LSISGIIVAVVAMSKSFLGT 304
Cdd:PRK13629 255 IISRASMLMVAVVMFFAFSCLFTLSPQNMAEAKAQNIPVLSYLanhfaSMTGTKSTFaitLEYAASIIALVAIFKSFFGH 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 305 YFGVIEGATE-VVKTTLQQVGIKKSRAFNRALSIMLVSLITFIVCCINPNAISMIYAISGPLIAMILFIMPTLSTYLIPA 383
Cdd:PRK13629 335 YLGTLEGLNGlILKFGYKGDKTKVSLGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPS 414

                        410       420
                 ....*....|....*....|.
gi 445988091 384 LKPWRS-IGNLITLIVGILCV 403
Cdd:PRK13629 415 LAKYRGrLDNVFVTVIGLLTI 435
Trp_Tyr_perm pfam03222
Tryptophan/tyrosine permease family;
18-310 6.77e-05

Tryptophan/tyrosine permease family;


Pssm-ID: 367404  Cd Length: 393  Bit Score: 44.58  E-value: 6.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091   18 GTAVGAGTLFLPIqlgsAGAVVLFITALVAWPLT--YWPHKALCQFILSSKTSAGEGITGAVTHYYGKKiGNLITTLYFi 95
Cdd:pfam03222  14 GTAIGAGMLALPV----ATAGAGFIPSLLLLILSwfLMLASGLLLLEVYLWYPEGASFNTLAKDLLGKK-GNIIAGLVY- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091   96 AFFVVVLIYA-VAITNSLTEQLAKHMVIDLRIRMLVSLGVVLILNLIFLMGRHATIRVMGFLVFPLIAYFLFLSIYLVGS 174
Cdd:pfam03222  88 AFLLYILTYAyISGGGSILSRVIPEMFGIPWSARAAPLIFTLLFGPFVWAGTKAVDRINRVLIFGKIIAFALVFSGLLPK 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091  175 WQPDLLTTQVefNQNTLHQIWISIPVMVFAFSHTPIISTFAidrreKYGEHAMDKCKKIMKVAYLIICISVLFFVFSCLL 254
Cdd:pfam03222 168 IKGDLLLDAL--DTSYWPYILMALPVFFTSFGFHGNVPSLY-----KYYGGNVKKVRKAILIGTAIPLVLYILWQLATLG 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 445988091  255 SIPPSYIEAAKEEGV---TILSALSMLPNAPAwLSISGIIVAVVAMSKSFLGTYFGVIE 310
Cdd:pfam03222 241 NLPREEFAPIIAKGGnldTLVEALLGVLKSPS-FELALELFSFFALATSFLGVALGLFD 298
 
Name Accession Description Interval E-value
SdaC COG0814
Amino acid permease [Amino acid transport and metabolism];
1-409 1.05e-93

Amino acid permease [Amino acid transport and metabolism];


Pssm-ID: 440576  Cd Length: 401  Bit Score: 287.04  E-value: 1.05e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091   1 MSNIWSKEETLWSFALYGTAVGAGTLFLPIQLGSAGAVVLFITALVAWPLTYWPHKALCQFILSSKtsAGEGITGAVTHY 80
Cdd:COG0814    4 KAMKWRKSDLGWVLLIAGTAIGAGMLALPIAAGGGGFWPSLLLLLLAWPLMYLSHLLLLEVNLSSP--PGADITTVVEEY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091  81 YGKKIGNLITTLYFIAFFVVVLIYAVAITNSLTEQLAKHMVIDLrIRMLVSLGVVLILNLIFLMGRHATIRVMGFLVFPL 160
Cdd:COG0814   82 LGKGGGILIGLLYFFLLYPLLLAYISGGGNILASFLVNQLGLTI-PRWLLSLIFILVLGAIVWLGTRLVDRVNRILVFPK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 161 IAYFLFLSIYLVGSWQPDLLTTQVEFnqNTLHQIWISIPVMVFAFSHTPIISTFAIDrrekYGEHAmDKCKKIMKVAYLI 240
Cdd:COG0814  161 IIAFLLLSLYLIPHWNLANLLNSALP--SYLKYLWLALPVLLTSFGFHPIIPSLVKY----YRKDA-KKLRRAILIGSLI 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 241 ICISVLFFVFSCLLSIPPSYIEAAKEEGVTILSALSMLPNAPaWLSISGIIVAVVAMSKSFLGTYFGVIEGATEVVKttl 320
Cdd:COG0814  234 PLVIYLFWVFSCLGSLPPEEFAEAKAQNISLLSALANVFNSP-LISYLGPLFAFFAIATSFLGVYLGLFDFLADLFK--- 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 321 qqvgiKKSRAFNRALSIMLVSLITFIVCCINPNAISMIYAISGPLIAMILFIMPTLSTYLIPALKPWR------SIGNLI 394
Cdd:COG0814  310 -----KKKSKKGRLKTALLTFLPPWIVALLNPSIFILALGYAGPIIAILLFILPALLVWKVRARFPLKyrvpggKLSLIF 384

                        410
                 ....*....|....*
gi 445988091 395 TLIVGILCVSVMFFS 409
Cdd:COG0814  385 VILFGLLAISAQILS 399
PRK13629 PRK13629
threonine/serine transporter TdcC; Provisional
 5-403 5.09e-59

threonine/serine transporter TdcC; Provisional


Pssm-ID: 184191  Cd Length: 443  Bit Score: 198.53  E-value: 5.09e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091   5 WSKEETLWSFALYGTAVGAGTLFLPIQLGSAGAVVLFITALVAWPLTYWPHKALCQFILSSKTSAGEgITGAVTHYYGKK 84
Cdd:PRK13629  17 WRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGN-ITETVEEHFGKT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091  85 IGNLITTLYFIAFFVVVLIYAVAITNSLTEQLAKHMVIDLRIRMLVSLGVVLILNLIFLMGRHATIRVMGFLVFPLIAYF 164
Cdd:PRK13629  96 GGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 165 LFLSIYLVGSWQPDLLtTQVEFNQ-------NTLHQIWISIPVMVFAFSHTPIISTFAIDRREKY-----GEHAMDKCKK 232
Cdd:PRK13629 176 VLISLSLIPYWNSAVI-DQVDLGSlsltghdGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYekdfgRDFTERKCSQ 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 233 IMKVAYLIICISVLFFVFSCLLSIPPSYIEAAKEEGVTILSAL-----SMLPNAPAW---LSISGIIVAVVAMSKSFLGT 304
Cdd:PRK13629 255 IISRASMLMVAVVMFFAFSCLFTLSPQNMAEAKAQNIPVLSYLanhfaSMTGTKSTFaitLEYAASIIALVAIFKSFFGH 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091 305 YFGVIEGATE-VVKTTLQQVGIKKSRAFNRALSIMLVSLITFIVCCINPNAISMIYAISGPLIAMILFIMPTLSTYLIPA 383
Cdd:PRK13629 335 YLGTLEGLNGlILKFGYKGDKTKVSLGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPS 414

                        410       420
                 ....*....|....*....|.
gi 445988091 384 LKPWRS-IGNLITLIVGILCV 403
Cdd:PRK13629 415 LAKYRGrLDNVFVTVIGLLTI 435
Trp_Tyr_perm pfam03222
Tryptophan/tyrosine permease family;
18-310 6.77e-05

Tryptophan/tyrosine permease family;


Pssm-ID: 367404  Cd Length: 393  Bit Score: 44.58  E-value: 6.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091   18 GTAVGAGTLFLPIqlgsAGAVVLFITALVAWPLT--YWPHKALCQFILSSKTSAGEGITGAVTHYYGKKiGNLITTLYFi 95
Cdd:pfam03222  14 GTAIGAGMLALPV----ATAGAGFIPSLLLLILSwfLMLASGLLLLEVYLWYPEGASFNTLAKDLLGKK-GNIIAGLVY- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091   96 AFFVVVLIYA-VAITNSLTEQLAKHMVIDLRIRMLVSLGVVLILNLIFLMGRHATIRVMGFLVFPLIAYFLFLSIYLVGS 174
Cdd:pfam03222  88 AFLLYILTYAyISGGGSILSRVIPEMFGIPWSARAAPLIFTLLFGPFVWAGTKAVDRINRVLIFGKIIAFALVFSGLLPK 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445988091  175 WQPDLLTTQVefNQNTLHQIWISIPVMVFAFSHTPIISTFAidrreKYGEHAMDKCKKIMKVAYLIICISVLFFVFSCLL 254
Cdd:pfam03222 168 IKGDLLLDAL--DTSYWPYILMALPVFFTSFGFHGNVPSLY-----KYYGGNVKKVRKAILIGTAIPLVLYILWQLATLG 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 445988091  255 SIPPSYIEAAKEEGV---TILSALSMLPNAPAwLSISGIIVAVVAMSKSFLGTYFGVIE 310
Cdd:pfam03222 241 NLPREEFAPIIAKGGnldTLVEALLGVLKSPS-FELALELFSFFALATSFLGVALGLFD 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH