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Conserved domains on  [gi|445995537|ref|WP_000073392|]
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MULTISPECIES: 1,2-phenylacetyl-CoA epoxidase subunit PaaB [Enterobacteriaceae]

Protein Classification

phenylacetate-CoA oxygenase subunit PaaB( domain architecture ID 17619449)

phenylacetate-CoA oxygenase subunit PaaB is the catalytic subunit of the multisubunit phenylacetyl-coenzyme A oxygenase complex that catalyzes the oxygenation of phenylacetyl-CoA to form 1,2-epoxyphenylacetyl-CoA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PA_CoA_Oxy2 TIGR02157
phenylacetate-CoA oxygenase, PaaH subunit; Phenylacetate-CoA oxygenase is comprised of a five ...
 6-95 1.77e-57

phenylacetate-CoA oxygenase, PaaH subunit; Phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (PA) degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA. [Energy metabolism, Other]


:

Pssm-ID: 274002  Cd Length: 90  Bit Score: 171.58  E-value: 1.77e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445995537   6 WPLYEVFVRGKQGLSHRHVGSLHAADERMALENARDAYTRRSEGCSIWVVKASEIVASQPEERGEFFDPAESKVYRHPTF 85
Cdd:TIGR02157  1 WPLYEVFVRSKSGLPHQHVGSLHAPDEEMALMMARDNYTRREEGVSIWVVKASHIVASTPDEREEFFDPAEDKVYRHPTF 80

                         90
                 ....*....|
gi 445995537  86 YSIPDGIEHM 95
Cdd:TIGR02157 81 YGIPDRVWHM 90
 
Name Accession Description Interval E-value
PA_CoA_Oxy2 TIGR02157
phenylacetate-CoA oxygenase, PaaH subunit; Phenylacetate-CoA oxygenase is comprised of a five ...
 6-95 1.77e-57

phenylacetate-CoA oxygenase, PaaH subunit; Phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (PA) degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA. [Energy metabolism, Other]


Pssm-ID: 274002  Cd Length: 90  Bit Score: 171.58  E-value: 1.77e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445995537   6 WPLYEVFVRGKQGLSHRHVGSLHAADERMALENARDAYTRRSEGCSIWVVKASEIVASQPEERGEFFDPAESKVYRHPTF 85
Cdd:TIGR02157  1 WPLYEVFVRSKSGLPHQHVGSLHAPDEEMALMMARDNYTRREEGVSIWVVKASHIVASTPDEREEFFDPAEDKVYRHPTF 80

                         90
                 ....*....|
gi 445995537  86 YSIPDGIEHM 95
Cdd:TIGR02157 81 YGIPDRVWHM 90
PaaB COG3460
1,2-phenylacetyl-CoA epoxidase, PaaB subunit [Secondary metabolites biosynthesis, transport ...
 1-95 1.93e-54

1,2-phenylacetyl-CoA epoxidase, PaaB subunit [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442683  Cd Length: 98  Bit Score: 163.97  E-value: 1.93e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445995537  1 MSNVYWPLYEVFVRGKQGLSHRHVGSLHAADERMALENARDAYTRRSEGCSIWVVKASEIVASQPEERGEFFDPAESKVY 80
Cdd:COG3460   4 ASATEWPLWEVFVRSKPGLPHRHVGSLHAPDAEMALQNARDVFTRREEGVSIWVVPSDAITASSPEEKDAFFDPAADKVY 83

                        90
                ....*....|....*
gi 445995537 81 RHPTFYSIPDGIEHM 95
Cdd:COG3460  84 RHPTFYEVPEKVEHM 98
PaaB pfam06243
Phenylacetic acid degradation B; Phenylacetic acid degradation protein B (PaaB) is thought to ...
 6-92 6.03e-54

Phenylacetic acid degradation B; Phenylacetic acid degradation protein B (PaaB) is thought to be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation.


Pssm-ID: 428844  Cd Length: 88  Bit Score: 162.43  E-value: 6.03e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445995537   6 WPLYEVFVRGKQGLSHRHVGSLHAADERMALENARDAYTRRSEGCSIWVVKASEIVASQPEERGEFFDPAESKVYRHPTF 85
Cdd:pfam06243  2 WPLWEVFVRSKRGLPHQHVGSLHAPDAEMALQNARDVYTRRNEGVSIWVVPSSDITASDPEEKEPFFEPADDKVYRHPTF 81


                 ....*..
gi 445995537  86 YSIPDGI 92
Cdd:pfam06243 82 YGVPEEV 88
 
Name Accession Description Interval E-value
PA_CoA_Oxy2 TIGR02157
phenylacetate-CoA oxygenase, PaaH subunit; Phenylacetate-CoA oxygenase is comprised of a five ...
 6-95 1.77e-57

phenylacetate-CoA oxygenase, PaaH subunit; Phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (PA) degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA. [Energy metabolism, Other]


Pssm-ID: 274002  Cd Length: 90  Bit Score: 171.58  E-value: 1.77e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445995537   6 WPLYEVFVRGKQGLSHRHVGSLHAADERMALENARDAYTRRSEGCSIWVVKASEIVASQPEERGEFFDPAESKVYRHPTF 85
Cdd:TIGR02157  1 WPLYEVFVRSKSGLPHQHVGSLHAPDEEMALMMARDNYTRREEGVSIWVVKASHIVASTPDEREEFFDPAEDKVYRHPTF 80

                         90
                 ....*....|
gi 445995537  86 YSIPDGIEHM 95
Cdd:TIGR02157 81 YGIPDRVWHM 90
PaaB COG3460
1,2-phenylacetyl-CoA epoxidase, PaaB subunit [Secondary metabolites biosynthesis, transport ...
 1-95 1.93e-54

1,2-phenylacetyl-CoA epoxidase, PaaB subunit [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442683  Cd Length: 98  Bit Score: 163.97  E-value: 1.93e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445995537  1 MSNVYWPLYEVFVRGKQGLSHRHVGSLHAADERMALENARDAYTRRSEGCSIWVVKASEIVASQPEERGEFFDPAESKVY 80
Cdd:COG3460   4 ASATEWPLWEVFVRSKPGLPHRHVGSLHAPDAEMALQNARDVFTRREEGVSIWVVPSDAITASSPEEKDAFFDPAADKVY 83

                        90
                ....*....|....*
gi 445995537 81 RHPTFYSIPDGIEHM 95
Cdd:COG3460  84 RHPTFYEVPEKVEHM 98
PaaB pfam06243
Phenylacetic acid degradation B; Phenylacetic acid degradation protein B (PaaB) is thought to ...
 6-92 6.03e-54

Phenylacetic acid degradation B; Phenylacetic acid degradation protein B (PaaB) is thought to be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation.


Pssm-ID: 428844  Cd Length: 88  Bit Score: 162.43  E-value: 6.03e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445995537   6 WPLYEVFVRGKQGLSHRHVGSLHAADERMALENARDAYTRRSEGCSIWVVKASEIVASQPEERGEFFDPAESKVYRHPTF 85
Cdd:pfam06243  2 WPLWEVFVRSKRGLPHQHVGSLHAPDAEMALQNARDVYTRRNEGVSIWVVPSSDITASDPEEKEPFFEPADDKVYRHPTF 81


                 ....*..
gi 445995537  86 YSIPDGI 92
Cdd:pfam06243 82 YGVPEEV 88
Htur_1727_fam TIGR04031
rSAM-partnered protein, Htur_1727 family; Members of this protein family show homology to the ...
 9-60 2.08e-03

rSAM-partnered protein, Htur_1727 family; Members of this protein family show homology to the putative PaaH (or PaaB) subunit of the phenylacetate-CoA oxygenase complex. However, all members are found in the Halobacteriales in the vicinity of a radical SAM protein homologous to the PqqE protein of pyroquinoline quinone (PQQ) biosynthesis. Members are well-conserved to about residue 75, but then become low-complexity and hypervariable.


Pssm-ID: 188546  Cd Length: 71  Bit Score: 33.75  E-value: 2.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 445995537   9 YEVFVRGKQGLSHRHVGSLHAADERMALENARDAYTRRSEgcSIWVVKASEI 60
Cdd:TIGR04031 17 WELFVREDSEDPLTHVGSVSAPSADIAREQACSLFAWYAE--DLWVCPADDV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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